CN201211188Y - Portable blood glucose detector based on multi-ring array photoacoustic sensor - Google Patents
Portable blood glucose detector based on multi-ring array photoacoustic sensor Download PDFInfo
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- CN201211188Y CN201211188Y CNU200820113091XU CN200820113091U CN201211188Y CN 201211188 Y CN201211188 Y CN 201211188Y CN U200820113091X U CNU200820113091X U CN U200820113091XU CN 200820113091 U CN200820113091 U CN 200820113091U CN 201211188 Y CN201211188 Y CN 201211188Y
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Abstract
本实用新型涉及一种基于多环阵列光声传感技术的便携式无创血糖检测仪，它包括由激光发生器、光纤、聚焦透镜和驱动电路组成的光学辐射单元A、由阻抗匹配电路、信号放大电路、信号滤波电路、A/D转换电路、脉冲信号源及信号处理器组成的信号处理单元B、由中空多环阵列超声传感器、测试槽组成的测试传感单元C以及输入按键、显示屏和电池。被测手指涂上超声耦合液后，伸入测试槽；由于采用前向接收模式的多环阵列光声传感技术，可沿深度方向进行连续A型动态聚焦扫描监测人体血糖含量，同时提供深度方向多个位点的血糖光声数据。本实用新型检测时无创伤，不需提取血液；采用小型半导体激光管作为光源，系统造价较低，轻巧便于携带。
The utility model relates to a portable non-invasive blood sugar detector based on multi-ring array photoacoustic sensing technology, which includes an optical radiation unit A composed of a laser generator, an optical fiber, a focusing lens and a driving circuit, an impedance matching circuit, a signal amplification Circuit, signal filtering circuit, A/D conversion circuit, signal processing unit B composed of pulse signal source and signal processor, test sensing unit C composed of hollow multi-ring array ultrasonic sensor, test slot, input button, display screen and Battery. After the finger to be tested is coated with ultrasonic coupling fluid, it is extended into the test slot; due to the use of multi-ring array photoacoustic sensing technology in the forward receiving mode, continuous A-type dynamic focus scanning can be performed along the depth direction to monitor the blood sugar content of the human body, and at the same time provide depth Direction of blood glucose photoacoustic data at multiple sites. The utility model has no trauma during detection and does not need to extract blood; a small semiconductor laser tube is used as a light source, the system cost is low, and the system is light and portable.
Description
Technical field
This utility model relates to biomedical measurement and technical field of medical instruments, is specifically related to a kind of portable non-invasive blood-sugar detecting instrument based on multi-ring array light sound sensor.
Background technology
Diabetes are global frequently-occurring disease and commonly encountered diseases, are the third-largest dangerous diseases that is only second to cardiovascular diseases and cancer, and the long-time disorder of blood sugar concentration can cause complication such as blind, renal failure, so diabetes have become a big killer who threatens the human life.To control this disease effectively, need the blood sugar concentration of real-time detection diabetics, thereby determine concrete dosage and diagnosis scheme, become the key technology of diabetes diagnosis and treatment.Current blood sugar test still generally adopts the mediatory type detection means that wound or Wicresoft are arranged, although the end that this mode only needs several microlitres is blood and cooperate corresponding reagent paper slightly, but storage condition is bigger to the reagent paper influence, and pain makes the patient still avoid this mode as far as possible.Therefore, the Woundless blood sugar means of testing of non-mediatory type just becomes diabetes patient's expectation.
Present most typical representative is based on the near infrared spectroscopic method of optical technology, but since glucose molecule very little in the near infrared absorption value, disturb very greatly, and require accuracy of instrument and signal to noise ratio higher.When measuring, the interference that is subjected to other compositions of human body such as skeleton, muscle and fat etc. is very big, not only need to consider to improve precision when therefore setting up mathematical model, also to consider actual feasibility when instrument development, its Clinical feasibility and the suitability are still waiting research, and the optical means of similar blood glucose measurement also has far red light Zymography, Raman spectrum analysis method, acousto-optic Zymography, light scattering Zymography and light polarization Zymography etc.
Summary of the invention
The technical problems to be solved in the utility model provides a kind of portable non-invasive blood-sugar detecting instrument based on multi-ring array light sound sensor.
For solving the problems of the technologies described above, the technical solution of the utility model is: a kind of portable non-invasive blood-sugar detecting instrument based on the multi-ring array light sound sensor technology, and it comprises by laser generator, optical fiber, the optical radiation unit A that condenser lens and drive circuit are formed, by the mutual impedance matching circuit that connects of circuit successively, signal amplification circuit, signal filter circuit, the A/D change-over circuit, the signal processing unit B that pulse signal source and the signal processor that is connected with A/D change-over circuit lead are formed, by the multi-ring array sonac, the test sensing unit C that test trough is formed, constitute the external control cells D by the input button, the signal display unit E that constitutes by display screen, provide unit F with the energy that constitutes by battery; The laser generator that is connected with drive circuit is connected with condenser lens by optical fiber, is placed in test groove on the multi-ring array sonac in the below of condenser lens; Test trough is connected with impedance matching circuit lead among the signal processing unit B, and the pulse signal source of signal processing unit B is connected with the drive circuit lead, and signal processor is connected with the display screen lead with the input button respectively; Battery is connected with said units A, B, C, D, E difference circuit.Described laser generator adopts the quasiconductor pulsed laser diode of miniaturization, the wave-length coverage of pulse laser one or more wavelength that are ultraviolet to the infra-red range.The center of laser generator, condenser lens and hollow multi-ring array sonac all is positioned on the same axis, constitutes incorporate coaxial confocal structure.Described hollow multi-ring array sonac is the multi-ring coil structures of hollow, adopts piezoelectric, comprises Lithium metaniobate, composite, piezoelectric ceramics and PVDF thin film.
Employing may further comprise the steps based on the method for the portable non-invasive blood-sugar detecting instrument detection blood glucose of multi-ring array light sound sensor technology:
(1) after tested personnel's tested finger was coated ultrasonic coupling liquid, fingernail stretched into test trough up, opened blood-sugar detecting instrument; The multi-wavelength pulse laser of laser generator timesharing emission is coupled in the optical fiber,, and sees through fingernail and incides on the blood vessel excitation generation photoacoustic signal to the tested finger that is positioned at the condenser lens below by optical fiber and condenser lens focused radiation;
(2) photoacoustic signal reaches the multi-ring array sonac that is positioned at below the test trough, the multi-ring array sonac adopts forward mode to survey photoacoustic signal, carry out A type dynamic focusing scanning at depth direction, collect the blood glucose optoacoustic data in a plurality of sites of depth direction;
(3) the photoacoustic signal data input signal processing unit B that collects carries out date processing, draws the blood sugar content in a plurality of sites and is shown or follow-up printing by display screen.
The beneficial effects of the utility model are:
1. this utility model adopts the multi-ring array light sound sensor technology of forward direction receiving mode, can carry out the blood sugar content that continuous A type dynamic focusing scanning monitoring human is pointed along depth direction, and the blood glucose optoacoustic data in a plurality of sites are provided simultaneously.
2. do not have wound when detecting, need not extract blood and reagent paper is provided, avoid the influence of cross infection and environment.
3. the coaxial confocal structure of photo-acoustic excitation and multi-ring array light sound sensor can greatly improve exciting and sensing efficient of optoacoustic, improves A type investigation depth when effectively reducing the laser energy requirement.
4. the semiconductor laser tube that adopts miniaturization is as light source, and system cost is relatively low, and light and handy portable structure has good adaptability and practicality, and is easy to utilize.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
Fig. 2 is a test sensing unit sketch map of the present utility model.
Fig. 3 is a hollow multi-ring array sonac schematic cross section.
The specific embodiment
Embodiment: a kind of portable non-invasive blood-sugar detecting instrument based on the multi-ring array light sound sensor technology, it comprises by laser generator 1, optical fiber 2, the optical radiation unit A that condenser lens 3 and drive circuit 4 are formed, by the mutual impedance matching circuit 5 that connects of circuit successively, signal amplification circuit 6, signal filter circuit 7, A/D change-over circuit 8, the signal processing unit B that pulse signal source 10 and the signal processor 9 that is connected with A/D change-over circuit 8 leads are formed, by hollow multi-ring array sonac 11, the test sensing unit C that test trough 13 is formed, constitute the external control cells D by input button 16, the signal display unit E that constitutes by display screen 17, provide unit F with the energy that constitutes by battery 18; The laser generator that is connected with drive circuit 41 is connected with condenser lens 3 by optical fiber 2, is placed in the below that test trough 13 on the hollow multi-ring array sonac 11 is positioned at condenser lens 3; Test trough 13 is connected with impedance matching circuit 5 leads among the signal processing unit B, and the pulse signal source 10 of signal processing unit B is connected with drive circuit 4 leads, and signal processor 9 is connected with display screen 17 leads with input button 16 respectively; Battery 18 is connected with said units A, B, C, D, E difference circuit.
Laser generator 1 adopts miniaturization pulse semiconductor laser diode (PGAS1S24, C860091E, EG﹠amp; G), operation wavelength is respectively 905nm and 1550nm, and single pulse energy is respectively 4uJ and 0.8uJ, and laser energy is radiated on the tested finger after focusing on by optical fiber 2 and condenser lens 3, sees through translucent fingernail and excites the finger blood vessel to produce photoacoustic signal; Be placed on above the hollow multi-ring array sonac 11 in the test trough 13 by the finger of side object, test trough 13 is column type cuboid container made from synthetic resin, scribbles ultrasonic coupling liquid 12 on the tested finger 14 and is beneficial to the velocity of sound and matches multi-ring array sonac 11.Wherein, the material of hollow multi-ring array pick off 11 is a piezoelectric ceramics, and the work centre frequency is 5MHz, and the number of ring is 7, is designed to equally spaced hollow planar rings coil structures, and the ring spacing is not more than half-wavelength, and wherein the velocity of sound is decided to be 1500m/s.The center of laser generator 1, condenser lens 3 and hollow multi-ring array sonac 11 all is positioned on the same axis, constitutes incorporate coaxial confocal structure.
Claims (3)
1. portable non-invasive blood-sugar detecting instrument based on the multi-ring array light sound sensor technology, it is characterized in that: it comprises by laser generator (1), optical fiber (2), the optical radiation unit A that condenser lens (3) and drive circuit (4) are formed, by the mutual impedance matching circuit (5) that connects of circuit successively, signal amplification circuit (6), signal filter circuit (7), A/D change-over circuit (8), the signal processing unit B that pulse signal source (10) and the signal processor (9) that is connected with A/D change-over circuit (8) lead are formed, by hollow multi-ring array sonac (11), the test sensing unit C that test trough (13) is formed, constitute the external control cells D by input button (16), signal display unit E by display screen (17) formation, provide unit F with the energy that constitutes by battery (18); The laser generator (1) that is connected with drive circuit (4) is connected with condenser lens (3) by optical fiber (2), is placed in the below that test trough (13) on the hollow multi-ring array sonac (11) is positioned at condenser lens (3); Test trough (13) is connected with impedance matching circuit (5) lead among the signal processing unit B, the pulse signal source of signal processing unit B (10) is connected with drive circuit (4) lead, and signal processor (9) is connected with display screen (17) lead with input button (16) respectively; Battery (18) is connected with said units A, B, C, D, E difference circuit; The center of laser generator (1), condenser lens (3) and hollow multi-ring array sonac (11) all is positioned on the same axis, constitutes incorporate coaxial confocal structure.
2. the portable non-invasive blood-sugar detecting instrument based on the multi-ring array light sound sensor technology according to claim 1, it is characterized in that: described laser generator (1) adopts the quasiconductor pulsed laser diode, the wave-length coverage of pulse laser one or more wavelength that are ultraviolet to the infra-red range.
3. the portable non-invasive blood-sugar detecting instrument based on the multi-ring array light sound sensor technology according to claim 1 is characterized in that: described hollow multi-ring array sonac (11) is the multi-ring coil structures of hollow.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200820113091XU CN201211188Y (en) | 2008-07-03 | 2008-07-03 | Portable blood glucose detector based on multi-ring array photoacoustic sensor |
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| Application Number | Priority Date | Filing Date | Title |
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| CNU200820113091XU CN201211188Y (en) | 2008-07-03 | 2008-07-03 | Portable blood glucose detector based on multi-ring array photoacoustic sensor |
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| CN201211188Y true CN201211188Y (en) | 2009-03-25 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100546541C (en) * | 2008-07-03 | 2009-10-07 | 江西科技师范学院 | Portable blood sugar detector and detection method based on multi-ring array light sound sensor |
| CN102183464A (en) * | 2011-01-28 | 2011-09-14 | 华南理工大学 | Linear array optical fiber coupling photoacoustic detection system and detection method thereof |
| CN104296697A (en) * | 2013-07-16 | 2015-01-21 | 桂林电子科技大学 | Finger tip surface roughness-based measuring method |
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| CN109497964A (en) * | 2018-10-29 | 2019-03-22 | 中国科学院上海技术物理研究所 | A kind of human vas detection system based on Laser Photoacoustic Spectroscopy |
-
2008
- 2008-07-03 CN CNU200820113091XU patent/CN201211188Y/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100546541C (en) * | 2008-07-03 | 2009-10-07 | 江西科技师范学院 | Portable blood sugar detector and detection method based on multi-ring array light sound sensor |
| CN102183464A (en) * | 2011-01-28 | 2011-09-14 | 华南理工大学 | Linear array optical fiber coupling photoacoustic detection system and detection method thereof |
| CN104296697A (en) * | 2013-07-16 | 2015-01-21 | 桂林电子科技大学 | Finger tip surface roughness-based measuring method |
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| CN109497964A (en) * | 2018-10-29 | 2019-03-22 | 中国科学院上海技术物理研究所 | A kind of human vas detection system based on Laser Photoacoustic Spectroscopy |
| CN109497964B (en) * | 2018-10-29 | 2021-04-09 | 中国科学院上海技术物理研究所 | A Human Blood Vessel Detection System Based on Laser Photoacoustic Spectroscopy |
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| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Effective date of abandoning: 20080703 |
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| C25 | Abandonment of patent right or utility model to avoid double patenting |