CN201171816Y - A liquid pressure balance adjustment device for an independent perfusion bionic circulatory system - Google Patents
A liquid pressure balance adjustment device for an independent perfusion bionic circulatory system Download PDFInfo
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- CN201171816Y CN201171816Y CNU2008200980442U CN200820098044U CN201171816Y CN 201171816 Y CN201171816 Y CN 201171816Y CN U2008200980442 U CNU2008200980442 U CN U2008200980442U CN 200820098044 U CN200820098044 U CN 200820098044U CN 201171816 Y CN201171816 Y CN 201171816Y
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- 230000010412 perfusion Effects 0.000 title claims abstract description 28
- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 17
- 239000007788 liquid Substances 0.000 title claims abstract description 15
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 210000000056 organ Anatomy 0.000 description 10
- 238000000034 method Methods 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 4
- 238000004321 preservation Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
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Abstract
本实用新型涉及一种独立灌注仿生循环系统用液体压力平衡调节装置,它包括有容量室、活塞和进气管道,所述活塞装配于容量室内,两者紧密配合,以调节容量室内的气体容量,活塞前端设置有密封圈,防止漏气。所述容量室侧壁上连接进气管道,向容量室内输入气体,容量室下端设置一出气通道,通过该出气通道连接到独立灌注仿生循环系统的泵出管道的三通上,为循环管道中的液体提供合适的缓冲,不同的气体容量可用于不同的灌注流量和流速,在所述进气管道和出气通道上均设置有开关。本实用新型结构简单,使用方便,可方便地调节仿生独立循环系统中的灌注液体压力,可作为一次性用品使用。
The utility model relates to a liquid pressure balance regulating device for an independent perfusion bionic circulatory system, which comprises a capacity chamber, a piston and an air intake pipe, the piston is assembled in the capacity chamber, and the two are closely matched to adjust the gas capacity in the capacity chamber , The front end of the piston is provided with a sealing ring to prevent air leakage. The side wall of the capacity chamber is connected with an air inlet pipe, and gas is input into the capacity chamber, and an air outlet channel is provided at the lower end of the capacity chamber, through which the air outlet channel is connected to the tee of the pump out pipe of the independent perfusion bionic circulatory system. The liquid provides suitable cushioning, and different gas volumes can be used for different perfusion flow rates and flow rates. Switches are provided on both the air inlet pipe and the air outlet channel. The utility model has the advantages of simple structure and convenient use, can conveniently adjust the perfusion liquid pressure in the bionic independent circulation system, and can be used as a disposable product.
Description
技术领域 technical field
本实用新型涉及医疗器械及实验研究领域,具体涉及一种在独立灌注仿生循环系统中使用的液体压力平衡调节装置。The utility model relates to the field of medical equipment and experimental research, in particular to a liquid pressure balance regulating device used in an independent perfusion bionic circulation system.
背景技术 Background technique
器官移植已成为不少终末性器官疾病,特别是肝脏疾病和肾脏疾病的有效治疗手段,大器官体外保存时间和移植后器官存活质量尤为引人注目。目前很多减轻器官移植后排斥反应的方法在实验状态下有非常好的作用,但由于离体大器官采取单纯冷藏法保存,较短的保存时间以及低温状态使这些方法的临床应用受到了限制,旨在减轻移植器官排斥反应和诱导受者免疫耐受的转基因治疗在临床就难以实施。Organ transplantation has become an effective treatment for many end-organ diseases, especially liver and kidney diseases. The preservation time of large organs in vitro and the survival quality of organs after transplantation are particularly noticeable. At present, many methods for alleviating rejection after organ transplantation have a very good effect in the experimental state, but the clinical application of these methods is limited due to the simple cold storage method for isolated large organs, short storage time and low temperature state. Transgenic therapy aimed at alleviating rejection of transplanted organs and inducing immune tolerance in recipients is difficult to implement clinically.
离体器官体内环境模拟保存方式为离体大器官提供良好的保存条件,一定时限内的常温条件使离体器官的高效移植前预处理成为可能。The simulated preservation method of in vivo environment of isolated organs provides good preservation conditions for large isolated organs, and normal temperature conditions within a certain period of time make it possible for the efficient pretreatment of isolated organs before transplantation.
现代外科技术中,无论是较简单的血液透析还是比较复杂的体外循环,均是在人体脉管系统中完成的,其灌注压力的平衡借助于人体动静脉系统良好的血液压力调节机制。而体外器官独立灌注仿生循环系统中没有具有生理调节机制的人体脉管系统,灌注系统中普遍采用的硅胶管和人体血管是无法达到同样的液体压力调节功能的。In modern surgical techniques, whether it is relatively simple hemodialysis or relatively complex extracorporeal circulation, they are all completed in the human vasculature, and the balance of the perfusion pressure relies on the good blood pressure regulation mechanism of the human arteriovenous system. However, there is no human vascular system with a physiological adjustment mechanism in the bionic circulatory system for independent perfusion of organs in vitro, and the silicone tube and human blood vessels commonly used in the perfusion system cannot achieve the same fluid pressure regulation function.
鉴于目前独立灌注仿生循环系统中无法做到灌注液体压力的良好平衡,为了临床及实验研究的需要,目前迫切需要一种可用于独立灌注仿生循环系统中调节灌注压力的、结构简单、操作方便的辅助装置。In view of the fact that the current independent perfusion bionic circulatory system cannot achieve a good balance of the pressure of the perfusion fluid, in order to meet the needs of clinical and experimental research, there is an urgent need for a simple structure and easy operation that can be used to adjust the perfusion pressure in the independent perfusion bionic circulatory system. assisting equipments.
实用新型内容Utility model content
本实用新型为克服上述现有技术的不足,提供一种可用于独立灌注仿生循环系统中调节灌注液压力的、结构简单、操作方便的压力平衡调节装置。In order to overcome the shortcomings of the above-mentioned prior art, the utility model provides a pressure balance adjusting device which can be used for adjusting the pressure of the perfusate in an independent perfusion bionic circulation system, has a simple structure and is easy to operate.
本实用新型的技术方案如下:The technical scheme of the utility model is as follows:
一种独立灌注仿生循环系统用液体压力平衡调节装置,它包括有容量室、活塞和进气管道,所述活塞装配于容量室内,两者紧密配合,以调节容量室内的气体容量,活塞前端设置有密封圈,可防止漏气。所述容量室的下部侧壁上连接进气管道,向容量室内输入气体,容量室下端设置一出气通道,容量室通过该出气通道连接到独立灌注仿生循环系统的泵出管道的三通上,容量室内的气体可以为循环系统中的液体提供合适的缓冲,不同的气体容量可用于不同的灌注流量和流速。在所述进气管道和出气通道上均设置有开关。A liquid pressure balance adjustment device for an independent perfusion bionic circulatory system, which includes a volume chamber, a piston and an intake pipe, the piston is assembled in the volume chamber, and the two are closely matched to adjust the gas volume in the volume chamber. The front end of the piston is set There is a sealing ring to prevent air leakage. The lower side wall of the capacity chamber is connected with an air intake pipe, and gas is input into the capacity chamber, and an air outlet channel is arranged at the lower end of the capacity chamber, through which the capacity chamber is connected to the tee of the pumping pipeline of the independent perfusion bionic circulatory system, The gas in the volume chamber can provide a suitable buffer for the liquid in the circulation system, and different gas volumes can be used for different perfusion flows and flow rates. A switch is arranged on the air inlet pipe and the air outlet channel.
所述进气管道向上延伸高于容量室,可防止循环系统的灌注管道内的液体溢出。The air inlet pipe extends upwards higher than the capacity chamber, which can prevent the liquid in the perfusion pipe of the circulation system from overflowing.
本实用新型结构简单,使用方便,可方便地调节仿生独立循环系统中的灌注液体压力,可作为一次性用品使用。The utility model has the advantages of simple structure and convenient use, can conveniently adjust the perfusion liquid pressure in the bionic independent circulation system, and can be used as a disposable article.
附图说明 Description of drawings
图1是本实用新型结构示意图。Fig. 1 is the structural representation of the utility model.
具体实施方式 Detailed ways
下面结合附图和实施例对本实用新型进一步说明。Below in conjunction with accompanying drawing and embodiment the utility model is further described.
参见图1,本灌注液体压力平衡调节装置主要包括容量室1、活塞2和进气管道3,容量室1内径与活塞2外径一致,活塞2装配于容量室1内,两者恰好吻合,活塞2前端有密封圈4,容量室1下端有一个出气通道5,出气通道5上设置有一开关6,容量室1下部侧壁上连接进气管道3,进气管道3向上延伸到略高于容量室1的高度,进气管道3上端也设置有一开关7。Referring to Fig. 1, the perfusion liquid pressure balance adjustment device mainly includes a
使用方法:Instructions:
将该液体压力平衡调节装置的下端出气通道5连接到独立灌注仿生循环系统的泵出管道的三通上,打开进气管道3上的开关7,以手动或通过自控控制系统向上移动活塞2,以调节容量室1的气体容量,到了设定值后关上进气管道3上的开关7,再将容量室1下端出气通道5上的开关6打开,启动灌注泵,通过容量室1内的气体来调节灌注仿生循环系统中的灌注液体压力,从而实现独立灌注仿生循环系统灌注液体的压力平衡。Connect the
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Granted publication date: 20081231 |