CN1931300A - Externally applied medicine for treating women's dysmenorrhea - Google Patents

Abstract

The present invention is one kind of externally applied medicine administrated via umbilical part to treating women's dysmenorrheal. The externally applied medicine is prepared with 15 kinds of Chinese medicinal materials, including musk, Chinese trumpet creeper, cassia, asarum herb, dahurian angelica root, etc in certain weight proportion. The preparation process includes stoving the Chinese medicinal materials except musk and Chinese trumpet creeper, soaking in alcohol for one week and concentrating the soaked liquid; soaking Chinese trumpet creeper in rice vinegar for 24 hr, air drying and crushing; and mixing musk, the Chinese trumpet creeper powder and the soaked liquid. The externally applied medicine has fast absorption, small dosage, high treating effect and no toxic side effect.

Description

A kind of topical agent for the treatment of dysmenorrhes

(1) technical field under

The present invention relates to a kind of medicine for the treatment of dysmenorrhes, particularly a kind of topical agent by umbilical region administration, treatment dysmenorrhes.

(2) background technology

Dysmenorrhea is one of commonly encountered diseases of puzzlement adolescence, women's work and study, is having a strong impact on the quality of life of young and middle-aged women.At present commercially available treatment emmenagogue is many based on oral, and its Chinese medicine and western medicine side effect is many; There are deficiencies such as taking dose is big, mouthfeel is poor, administration number of times is many in Chinese medicine decoction and Chinese patent medicine.

(3) summary of the invention

The present invention is in order to overcome the deficiency of above technology, provides that a kind of therapeutic effect is good, easy to use, the topical agent of the treatment dysmenorrhes that has no side effect.

The topical agent of treatment dysmenorrhes of the present invention is characterized in that the topical agent made by the medicinal raw material and the preparation method of following weight portion,

Medicinal raw material: Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g;

Preparation method: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt 50-70% edible ethanol one week of infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;

Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;

Moschus sneak into above-mentioned 14 the flavor medicines in, behind the mix homogeneously promptly.

The effect of liniment of the present invention: promoting QI circulation for relieving depression, regulating menstruation and activating blood, the detumescence of relieving oedema or abdominal distension through diuresis or purgation, understand things pain-stopping.

Cure mainly: primary dysmenorrhea, menoxenia etc.

Medicament of the present invention promotes whole body and local blood circulation by through umbilical region administration, and the menstrual molimen emotion of releiving absorbs soon, and using dosage is little, and number of times is few, the safe ready health.Clinical experiment shows that curative effect of medicine of the present invention is fast, and is effective, has no side effect.

(4) specific embodiment

The present embodiment medicine is a kind of topical agent for the treatment of dysmenorrhes, and its medicinal raw material is:

Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g.

Preparation method is: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt one week of 60% edible ethanol infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;

Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;

Moschus sneak into above-mentioned 14 the flavor medicines in, be mixed into paste after, topical agent of the present invention.

Usage: get this product 2g and be applied on the adhesive plaster, be affixed on umbilical part, changed once in 48 hours, pass through sticked in preceding 3 days, and manifold card applies 3 and passes through the cycle.

Carry out following clinical trial:

According to the dysmenorrhea criterion of therapeutical effect that Ministry of Public Health bureau of drug administration formulates, choose light, in, severe pain is through person's (dysmenorrhea group) 100 examples, age 15-30 year, course of disease 2-10, selecting 30 dysmenorrhea persons else is matched group, age 15-30 year.Fill in questionnaire by the special messenger, detailed medical history-taking, organ diseases such as the comprehensive health check-up of warp all is not in the mood for, brain, kidney, and through abdominal part color doppler ultrasonography instrument detection uterus and the whole no abnormal findings of adnexa.

Therapeutic Method:

1 treatment group: the unguentum 2g that gets this foregoing description is applied on the adhesive plaster, is affixed on umbilical part, changes once in 48 hours, and pass through sticked in preceding 3 days, and manifold card applies 3 and passes through the cycle.

2 matched groups: oral somedon, 1 slice/time, 1-2 time/day, took medicine through preceding 3 days, serve on 5 days, serveing on 3 menstrual cycle is a course of treatment.

Efficacy result

Criterion of therapeutical effect: press the curative effect determinate standard that Ministry of Public Health bureau of drug administration formulates

Recent clinical cure: pain and other transference cure after the drug withdrawal, 3 cycles of drug withdrawal do not recur, and pain degree reverts to " 0 " degree.

Produce effects: reduce to below 1/2 of original branch

Effectively: reduce to below 1/3 of original branch

Invalid: as not have change.

After all case observation is finished three menstrual cycle,, the results are shown in Table 1 according to above standard determination curative effect.

Table 1: two groups of patients clinical curative effects of medicament of the present invention and somedon relatively

Group	Example number (example)	Cure (example)	Produce effects (example)	Effectively (example)	Invalid (example)	Total effective rate
							Medicament of the present invention	100	40	35	20	5	95％
Somedon	30	1	12	13	4	86.7％

Respectively the patient's (40 example) before and after the treatment is measured with healthy people's (20 example) hemorheology index, the results are shown in Table 2.In the table 2, one group is the hemorheology index before the dysmenorrhoea disease human therapy, and two groups is one group of hemorheology index behind the dysmenorrhoea disease human therapy, and three groups is healthy people's hemorheology index.

Table 2: two groups of hemorheology indexs of medicament of the present invention and somedon relatively

Group	The example number	Whole blood viscosity		Plasma viscosity (mps)	The whole blood reduced viscosity	Erythrocyte sedimentation rate	Packed cell volume (%)
								Height is cut	Low cutting
		One group	40							5.62±0.57 △	17.51±1.27 △	2.56±0.47 △	10.63±1.19 △	6.89±4.97 △△	42.69±2.80 △△
Two groups	40			5.18±0.08 #	15.78±0.09 ##	1.94±0.02 #	9.75±0.23 #	9.64±0.49 #	36.55±1.05 #
		Three groups	20							4.99±0.47	15.64±0.75	1.79±0.24	9.56±1.26	10.19±2.65	37.09±4.24

Annotate: control preceding comparison with this group, ^#P＜0.05, ^##P＜0.01;

Organize comparison with healthy people, ^△P＜0.05, ^{△ △}P＜0.01

Conclusion:

Experiment shows that significant difference is arranged between two groups, illustrates that medicament of the present invention is greatly improved on curative effect, has better therapeutic effect clinically.

Use the patient of medicament of the present invention, do not have any untoward reaction, illustrate without any side effects.

Claims (1)

1. topical agent for the treatment of dysmenorrhes is characterized in that the topical agent made by the medicinal raw material and the preparation method of following weight portion,

Medicinal raw material: Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g;

Preparation method: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt 50-70% edible ethanol one week of infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;

Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;

Moschus sneak into above-mentioned 14 the flavor medicines in, behind the mix homogeneously promptly.