CN1895273A - Preparation of nano-bird's nest microparticle - Google Patents
Preparation of nano-bird's nest microparticle Download PDFInfo
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- CN1895273A CN1895273A CNA2006100867464A CN200610086746A CN1895273A CN 1895273 A CN1895273 A CN 1895273A CN A2006100867464 A CNA2006100867464 A CN A2006100867464A CN 200610086746 A CN200610086746 A CN 200610086746A CN 1895273 A CN1895273 A CN 1895273A
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- nidus collocaliae
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A process for preparing the bird's nest nanoparticles includes such steps as traditionally drying and cleaning, pulverizing, by 200 meshes, pneumatic pulverizing, and shaping.
Description
Technical field
The present invention relates to a kind of preparation method of Nidus collocaliae element.
Background technology
Nidus collocaliae is built up the nest nest by Apodidae animal esculent swift and the multiple swallow class that belongs to together with condensation by mixings such as saliva and downs.Nidus collocaliae is again a rare medicinal herbs simply, has enriching yin and nourishing kidney, spermatogenesis benefit blood, stomach strengthening spleen invigorating, leukorrhagia stopping to control the effect of rushing down.Can be used for hectic fever, night sweat, dry cough or hemoptysis due to deficiency of lung-YIN, the pulmonary tuberculosis, and choking every diseases such as regurgitation, night sweat due to the deficiency of stomach-Yin.Upward say " book on Chinese herbal medicine meets former ": " transfer tonify deficiency labor, control to cough and tell red expectorant ".The traditional Chinese medical science thinks that it can " be gone into lung anger, go into kidney and grow water, go into the stomach invigorating middle warmer ", and " strongly invigorating primordial QI " supports lung yin greatly ", for " all after being ill void, particularly quality goods ".
Cubilose nutritive is abundant, and cubilose nutritive is abundant, inner protein 49.85%, elements such as carbohydrate 30.55% and little fat and phosphorus, sulfur, calcium, ferrum.Contain moisture 10.40% in the natural Nidus collocaliae, nitrogen substance is 57.40%, fat trace, no nitrogen extract 22.00%, fiber 1.40%, ash 8.70%.Remove the Nidus collocaliae of clean hair, its ash is 2.52%, can be dissolved in hydrochloric acid fully, contains phosphorus 0.035%, sulfur 1.10%; The Nidus collocaliae hydrolysis gets reducing sugar at least 17.36% (with glucose meter); Contain protein several (content reaches 49.85%, is mainly histidine 2.7% in the protein, arginase 12 .7%, cystine 2.4%, tryptophan 1.4%, tyrosinase 15 .6% etc., its aminoacid total content is 56%); Its nitrogen be distributed as amide (amide) nitrogen 10.08%, humin (humin) nitrogen 6.68%, arginine nitrogen is 19.35%, Guang nitronic acid nitrogen 3.39%, histidine nitrogen are 6.22%, and lysine nitrogen is 2.46%, monoamine (mono2amino) nitrogen 50.19%, non-ammonia (non2amino) nitrogen is 7.22%.Nidus collocaliae contains aminohexose (hexosamine) and similar mucinous material again.Nidus collocaliae is in wide-spread use among the people, being the high-class healthy product of the suitable meals of suitable medicine with valuable medicinal and delicious food.In a word, the main component of Nidus collocaliae is protein and Hydrocarbon, and these compositions are referred to as the Nidus collocaliae element, and there are some researches show that abroad the water extract of Nidus collocaliae has the myocardial contraction of enhancing and cardiac stimulant effect.
It also contains a kind of hydrolysis sugar crude protein, can promote the decomposition of immunocyte.Nidus collocaliae is except that being used as medicine, or the raw material of cosmetics, and the epidermal growth factor that contains in the Nidus collocaliae can promote the division growth of cell, so can promote the modification of damaged skin and the healing of wound surface, makes skin become smooth and flexible.
Nidus collocaliae because output is limited, is restricted its application as a kind of valuable medicinal and delicious food.Because Nidus collocaliae costs an arm and a leg, and utilizes nanotechnology to make the granule of 1～100nm, can improve the biological effectiveness of this medicine effectively, reduce dose.
Nanoscale science and technology is considered to generation and the development pole focus subject being material impact to a series of new and high technologies of 21 century, will become one of main science and technology of new century.Although it also only is some symptom of a trends to have occurred now that nanotechnology is applied to the research and development of Chinese medicine, it might develop the subject that makes new advances, new industry, and people will quicken the knowledge innovation in this field, makes contributions for realizing the modernization of Chinese medicine.
Nanotechnology is that material is made particle diameter is the particulate technology of 1～100nm, just has the people that nanotechnology is applied to field of medicaments as far back as 50～seventies of 20th century, and main purpose at that time is to be used for the target administration of anticancer class medicine to reduce its toxic and side effects.It has following characteristics: the dissolubility and the biological effectiveness that 1. improve Chinese medicine; 2. strengthen former powerfully, increase new effect; 3. promote traditional route of administration; 5. improve interaction with human body protein.
The preparation of nanometer Chinese medicine is that the most basic of research nanometer Chinese medicine also is sixty-four dollar question.When the research of Chinese medicine is introduced in nanotechnology, must consider the multiformity of Chinese prescription, the complexity of Chinese medicine ingredients.For example, the Chinese medicine single medicinal material can be divided into mineral drug, plant amedica, animal drugs and fungus medicine etc., and the effective site of Chinese medicine and effective ingredient comprise inorganic compound and organic compound, water soluble ingredient and liposoluble constituent etc. again.Therefore, at different medicines, when carrying out nanorize, must adopt different technology paths.How under the guidance of theory of Chinese medical science, to carry out the research of nanometer new product of Chinese medicine, with Chinese medicine make efficient, quick-acting, long-acting, dosage is little, the modern preparation of low toxicity, taking convenience, also is the problem that must consider when carrying out the Chinese medicine nanorize.
Single medicinal material supplies the basic medical material of Chinese medicine preparation after tradition is concocted processing.From ancient times to the present, Chinese medicine processing exists because of the form with bark and grass roots, though make Chinese medicine be admitted curative effect gradually by the world, the initial condition during its processing, transportation, storage prescription use makes it be difficult to incision modern's life.
Chinese medicine processing is that Chinese medicine is cut into lamellar, minority powdering, or dendritic for prescription or Chinese medicine production use, and this is the processing first time of Chinese crude drug, but can not directly take, and takes after needing to decoct processing, and decocting rate is lower, wastes natural resources of Chinese medicinal materials.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of nano Nidus collocaliae grain, can prepare the nano Nidus collocaliae material in this way, can improve its biological effectiveness, reduce its consumption.
The present invention adopts following technical scheme: a kind of preparation method of nano Nidus collocaliae, and this method comprises following process:
(1), Nidus collocaliae is carried out drying, purifies processing with traditional method;
(2), the Nidus collocaliae after will processing be ground at least 95% can be by the fine powder of 200 mesh sieves;
(3), fine powder is pulverized, obtaining the following ultramicro powder content of 500nm is the prepared slices of Chinese crude drugs more than 90% with jet mill;
(4) ultramicro powder is shaped to quantitatively lamellar, graininess or powdered decoction pieces.
Chinese medicine is because cell wall (the molecule shell of cell) has only small part to be pulverized in the cutting first time, the second time when pulverizing, so a large amount of effective ingredient can not be absorbed and affect the treatment.
The present invention is according to the characteristics of peculiar composition of having of Nidus collocaliae and medicinal component, utilize jet mill that the Nidus collocaliae fine powder of preprocess is ground into the lipid nanometer microgranule, wherein the content of the ultramicro powder below the 500nm is more than 90%, be the processing for the third time of Chinese medicine, can be shaped to powdery, lamellar, graininess on demand, become the medicinal raw material of quantitative package, produce Chinese patent medicine for prescription and use.Because the cellular elements shell is broken, effective ingredient is all overflowed, can directly take, and absorbance can improve 6～9 times than traditional decoction pieces, can reduce the dose of Nidus collocaliae, and saves natural resources of Chinese medicinal materials in a large number.
The specific embodiment
Be described further below in conjunction with the preparation method of specific embodiment nano-bird's nest microparticle of the present invention.
(1), Nidus collocaliae is carried out drying, purifies processing with traditional method.
(2), the Nidus collocaliae after will processing is ground at least 95% with ZJM-20/25 type high energy ball mill can be by the fine powder of 200 mesh sieves, Nidus collocaliae (Nidus collocaliae element) powder body is according to " 2005 editions one one of Chinese pharmacopoeia is up to the standards, and powder size is about 200 orders (＜74 μ m); The material of ball mill is rustless steel, and the recirculated water cooling is adopted in sealing, and rotating speed is that 0～800r/min is stepless adjustable.Ball-milling medium is respectively air and deionized water and adds modifier in water.Modifier is dodecyl sodium sulfate [CH3 (CH2) 10CH2SO3Na], and content 〉=97%, molecular weight are 272.38, and critical micelle concentration is 9.0 * 10
-3MolL
-1Sodium lauryl sulphate [CH3 (CH2) 10CH2SO4Na], critical micelle concentration is 8.60 * 10
-3MolL
-1
(3), the Nidus collocaliae fine powder is pulverized, obtain the following ultramicro powder content of 500nm and be the prepared slices of Chinese crude drugs more than 90% with jet mill.
(4) ultramicro powder is shaped to quantitatively lamellar, graininess or powdered decoction pieces.
The mensuration of Nidus collocaliae lipid nanoparticle analysis indexes
(1) X-ray diffraction analysis
Powder body sieves with 200 order mesh screens behind the ball milling, and ball-milled powder need be dried and be analyzed in the water, and temperature is controlled at below 260 ℃.X-ray diffractometer carries out diffraction analysis: CuK α, and λ=0.154nm, 4 °/min of scanning speed, sweep limits is 10 °～90 °.According to XRD diffraction pattern and formula:
Bg(2θ)＝0.9λ/Dcosθ+ηsinθ/cosθ
The crystallite dimension of powder behind the calculating ball milling.Bg (2 θ): the diffraction maximum that grain refinement and internal strain cause changes (half-peak breadth); D: crystallite dimension; η: internal strain coefficient, θ: Bragg angle.The Nidus collocaliae element is a fragile material, and easy fracture can be ignored internal strain, and therefore, formula should be:
Bg(2θ)＝0.9λ/Dcosθ
Wherein, Bg
2(2 θ)=B crystalline substance
2=B is real
2-B instrument
2B is real: the actual measurement half-peak breadth; The B instrument: the half-peak breadth that instrument causes, can demarcate by measuring the plain powder half-peak breadth of original Nidus collocaliae.
(2) particle size distribution analysis
Adopt laser scattering method, on multi-angle ultra-fine grain particle size analyzer, carry out.Experiment is the solvent dilution sample with the deionized water under 20 ℃, handles in conjunction with ultrasonic dispersing different samples is analyzed, and measures varigrained weight percentage in 3～3000nm scope.
(3) electron microscopic observation of grain crystal form looks
When preparation method of sample is used scanning electron microscope, cling one deck sample, after treatment, put on the ion sputtering coater gold-plated with the sample bench conducting resinl.During transmission electron microscope, with copper mesh carbon film is moved on to be equipped with in the alcoholic acid glass drying oven and clean, filter paper blots standby.The sample that takes a morsel is used ethanol dilution, behind ultra-sonic dispersion 2～3min, on the carbon film that drips to and oven dry.
Through check analysis, adopt the bird ' s-nest particles of method preparation of the present invention, grain crystal form shape is even, particle diameter at the ultramicro powder content below the 500nm more than 90%.
Claims (1)
1, a kind of preparation method of nano Nidus collocaliae, this method comprises following process:
(1), Nidus collocaliae is carried out drying, purifies processing with traditional method;
(2), the Nidus collocaliae after will processing be ground at least 95% can be by the fine powder of 200 mesh sieves;
(3), fine powder is pulverized, obtaining the following ultramicro powder content of 500nm is the prepared slices of Chinese crude drugs more than 90% with jet mill;
(4) ultramicro powder is shaped to quantitatively lamellar, graininess or powdered decoction pieces.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100867464A CN1895273A (en) | 2006-06-20 | 2006-06-20 | Preparation of nano-bird's nest microparticle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100867464A CN1895273A (en) | 2006-06-20 | 2006-06-20 | Preparation of nano-bird's nest microparticle |
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| Publication Number | Publication Date |
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| CN1895273A true CN1895273A (en) | 2007-01-17 |
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| CNA2006100867464A Pending CN1895273A (en) | 2006-06-20 | 2006-06-20 | Preparation of nano-bird's nest microparticle |
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| CN102204678A (en) * | 2011-06-10 | 2011-10-05 | 四川科伦新光健康药业有限公司 | Instant cubilose powder with efficacy of immunity enhancement and preparation method thereof |
| CN102239984A (en) * | 2011-05-23 | 2011-11-16 | 厦门思露生物科技有限公司 | Bird nest health-care product buccal tablet |
| CN104172153A (en) * | 2014-07-03 | 2014-12-03 | 大连海晏堂生物有限公司 | Instant cubilose product and preparation method thereof |
| CN104382837A (en) * | 2014-12-05 | 2015-03-04 | 燕之初颜如燕（厦门）生物科技有限公司 | Mask of unadulterated edible bird's nest powder and use method thereof |
| CN105341904A (en) * | 2015-09-28 | 2016-02-24 | 极燕生物有限公司 | Post curing type remolded cubilose and preparation method thereof |
| CN106107988A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | A kind of Nidus collocaliae microcapsule powder and preparation method thereof, purposes |
| CN106135886A (en) * | 2015-03-26 | 2016-11-23 | 极燕生物有限公司 | Use to steam in situ and melt the method that instant cubilose is prepared in coupling procedure ripple change |
| CN107495388A (en) * | 2017-10-20 | 2017-12-22 | 广西佛斯肽生物科技有限公司 | A kind of preparation method of bird's nest polypeptide powder |
| CN107647414A (en) * | 2017-10-20 | 2018-02-02 | 广西佛斯肽生物科技有限公司 | A kind of instant bird's nest collagen Gly-His-Lys |
| CN108576545A (en) * | 2018-05-24 | 2018-09-28 | 刘树民 | A kind of bird's nest effervescent tablet and preparation method thereof |
| CN112042935A (en) * | 2020-09-09 | 2020-12-08 | 厦门市燕之屋丝浓食品有限公司 | Cubilose concentrated solution and preparation method and application thereof |
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2006
- 2006-06-20 CN CNA2006100867464A patent/CN1895273A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102239984A (en) * | 2011-05-23 | 2011-11-16 | 厦门思露生物科技有限公司 | Bird nest health-care product buccal tablet |
| CN102204678A (en) * | 2011-06-10 | 2011-10-05 | 四川科伦新光健康药业有限公司 | Instant cubilose powder with efficacy of immunity enhancement and preparation method thereof |
| CN102204678B (en) * | 2011-06-10 | 2013-02-06 | 四川科伦新光健康药业有限公司 | Instant cubilose powder with efficacy of immunity enhancement and preparation method thereof |
| CN104172153A (en) * | 2014-07-03 | 2014-12-03 | 大连海晏堂生物有限公司 | Instant cubilose product and preparation method thereof |
| CN104382837A (en) * | 2014-12-05 | 2015-03-04 | 燕之初颜如燕（厦门）生物科技有限公司 | Mask of unadulterated edible bird's nest powder and use method thereof |
| CN106135886A (en) * | 2015-03-26 | 2016-11-23 | 极燕生物有限公司 | Use to steam in situ and melt the method that instant cubilose is prepared in coupling procedure ripple change |
| CN105341904A (en) * | 2015-09-28 | 2016-02-24 | 极燕生物有限公司 | Post curing type remolded cubilose and preparation method thereof |
| CN106107988A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | A kind of Nidus collocaliae microcapsule powder and preparation method thereof, purposes |
| CN107495388A (en) * | 2017-10-20 | 2017-12-22 | 广西佛斯肽生物科技有限公司 | A kind of preparation method of bird's nest polypeptide powder |
| CN107647414A (en) * | 2017-10-20 | 2018-02-02 | 广西佛斯肽生物科技有限公司 | A kind of instant bird's nest collagen Gly-His-Lys |
| CN108576545A (en) * | 2018-05-24 | 2018-09-28 | 刘树民 | A kind of bird's nest effervescent tablet and preparation method thereof |
| CN112042935A (en) * | 2020-09-09 | 2020-12-08 | 厦门市燕之屋丝浓食品有限公司 | Cubilose concentrated solution and preparation method and application thereof |
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