CN1886116B

CN1886116B - Stable personal wash soap composition and process to prepare the same

Info

Publication number: CN1886116B
Application number: CN2004800351106A
Authority: CN
Inventors: P·本德约帕海伊
Original assignee: Unilever NV
Current assignee: Unilever NV
Priority date: 2003-11-27
Filing date: 2004-11-16
Publication date: 2010-06-16
Anticipated expiration: 2024-11-16
Also published as: WO2005051343A1; CA2547554A1; AU2004292747A1; MXPA06005956A; BRPI0416433A; AU2004292747B2; ZA200604061B; EP1718272A1; CN1886116A; GB0403534D0

Abstract

A storage stable personal wash soap composition comprising 15-85 % detergent active, 0.1-20 % of skin lightening agent selected from niacin, niacinamide, their precursors and derivatives, and 0.02 % to 2 % of diethylene triamine penta acetic acid (DTPA).

Description

Stable personal cleansing soap composition and preparation method thereof

The present invention relates to the personal cleansing soap composition, particularly combine the stable personal cleansing soap composition of skin lightening beneficial agent (benefit agent) nicotiamide basically, also relate to its preparation method.

Personal cleansing soap composition of the present invention makes it possible at the soap apoplexy due to endogenous wind directly in conjunction with the skin benefit agent nicotiamide of a large amount more to give better skin lightening character of soap bar (bar), and said composition is still stable, the consumer attributes that has kept required product is even also be like this during long term storage under wet heat condition.

Usually, sunscreen and skin lightening agent such as nicotiamide and Parsol are skin benefit agents and are incorporated in the cosmetic formulations compatible with each other.

Skin lightening agent such as nicotiamide, lactic acid and other material are unsettled under alkaline pH usually.The personal cleansing preparation is generally soap base, and has and can be proved to be the deleterious alkaline pH of the preparation that contains the skin lightening agent.Therefore, preparing washing-off type (wash-off) product that contains these skin lightening agent is a problem.

Importantly, can not be to send a large amount of skin lightening agent such as nicotiamide in 30% to 80% the personal cleansing bar in wherein fatty matter total amount, because these chemical compounds are unsettled under alkaline pH at high temperature with conventional method preparation.Therefore, for by rinse-off products to the dermal delivery beneficial agent, have been found that for example to be necessary to use that those comprise the delivery system of cation type polymer.

WO 01/82884A1 discloses the Clean-soap bar that comprises 15% to 85% cleaning agent active component and 0.1% to 20% skin lightening agent.Preferably, 20-60 ℃ temperature the skin lightening agent is incorporated in the Clean-soap bar.Importantly, said preparation is formulated into and is cooperating type soap class/detergent formulations, and they will provide the skin lightening agent in the substrate that it was applied be the sending of improvement of nicotiamide, thereby is implemented in the maximum virtual value of the beneficial agent that uses in this preparation.

Although above-mentioned prior art provides the soap class/detergent formulations that makes it possible in the basic preparation of soap class/cleaning agent in conjunction with active component such as nicotiamide, though and this optionally collaborative preparation also provides the enhanced of skin benefit agent such as nicotiamide to send, and it is found that in this preparation still to have problems in conjunction with active component such as nicotiamide.This is because described preparation causes the storage stability forfeiture of product, and is particularly especially true under wet condition.Especially, it is found that preparation (described soap class comprises such as the sunscreen of nicotiamide or the skin lightening beneficial agent) variable color when long term storage that comprises the soap class that contains the unsaturated fatty acids material, particularly especially true in wet heat condition following time.

Therefore, variable color takes place during long term storage in known these sunscreen care protection soap bars under heat, wet, pasty state condition.Particularly has containing of 0.1% to 5% nicotiamide of unsaturated soap class or the soap base of fatty acid variable color in about 30-40 days usually under heat, wet, pasty state condition.Importantly, find that also even have 0.5 weight % or lower nicotiamide, they still occur the variable color and the problem of becoming sour at ambient temperature in the preparation that comprises the soap class that derives from unsaturated fatty acid (as oleic acid) and nicotiamide.

For above-mentioned reasons, the soap class of finding to derive from unsaturated fatty acid especially is incompatible with skin benefit agent such as nicotiamide, and often discovery causes the forfeiture of product variable color and consumer attributes thereof.In addition, consider the ferrum (Fe) in the soap preparation and the air oxidation of copper (Cu) impurity catalysis unsaturated fatty acids acid moieties, therefore attempt by use known Fe/Cu chelating agen ethylenediaminetetraacetic acid (the EDTA)/variable color of ethylidene hydroxyl diphosphate (EHDP) the described soap preparation of control in the presence of nicotiamide at the soap apoplexy due to endogenous wind, but find the stability problem that this is not enough to be avoided product, as contain the discoloration problem of the soap class of nicotiamide.More a large amount can not avoid the discoloration problem of the soap class of niacinamide-containing as the highest 0.2% EDTA-4Na (35% solution), 1% EHDP (60% solution).

Therefore, from the above obviously as can be known, the soap preparation as the personal cleansing preparation that contains nicotiamide (it comprise derive from the particularly soap class of unsaturated fatty acid) when storing, when particularly under heat, wet and pasty state condition, storing, the loss of stability that experience is shown by the product variable color.This variable color of described product form also causes the captivation forfeiture of product to consumer basically except the forfeiture of the formation balance that influences the soap preparation and relevant beneficial property thereof.In addition, because above-mentioned stability problem, be used in particular for realizing two-forty possible preparation delivering active ingredients, that in soap, contain the active component nicotiamide on the skin during use that the nicotiamide of extensive use and application need amount always is a problem in the art in the soap preparation though exist.

Therefore, basic purpose of the present invention is can provide to have the soap class that contains the unsaturated fatty acids material and the soap class/personal wash compositions of skin lightening agent/beneficial agent such as nicotiamide, storage stability when it will avoid long term storage and the problem of variable color are even also be like this during long term storage under wet heat condition.

Another object of the present invention is the cleaning agent active component with 15-85% can be provided and comprise the soap class that derives from unsaturated fatty acid and the soap preparation of skin lightening agent nicotiamide, personal cleansing bar particularly, it has required stability under alkaline pH and hot conditions, and the discoloration problem when by rinse-off products the dermal delivery beneficial agent not being had particularly to store under wet heat condition.

Another purpose of the present invention is that the non-discoloring storage stability soap preparation that contains nicotiamide can be provided, said preparation will be realized required storage stability, and this storage stability can not realize by using the conventional EDTA/EHDP chelating agen that is used for the trace Fe/Cu that this type of soap of chelating exists.

Another object of the present invention is the soap class/detergent formulations that can provide collaborative, it is provided at the sending of improvement of the skin lightening agent on its base material of using on the one hand, thereby obtain the maximum virtual value of used beneficial agent in said preparation, even the storage stability when avoiding under wet heat condition long term storage on the other hand and the problem of variable color.

Another purpose of the present invention is that the soap class/skin care formulation that comprises skin lightening agent such as nicotiamide and Parsol sunscreen can be provided; said preparation keeps the required effect level of nicotiamide and sunscreen for predetermined skin care benefit; and avoided the soap class simultaneously when long term storage, the discoloration problem during long term storage under heat, wet and pasty state condition particularly.

Another object of the present invention is to help to keep the stable storing combination of nicotiamide at the soap apoplexy due to endogenous wind, and need not to avoid unsaturated fatty acid basis soap class, and still realize required storage stability, even under the condition of moist and pasty state also is like this, thereby kept required product captivation/consumer attributes, and satisfied its market demands consumer.

Therefore according to an aspect of the present invention, personal cleansing/the cleanser compositions of stable storing is provided, it comprises the cleaning agent active component of 15-85%, the skin lightening agent that is selected from nicotinic acid, nicotiamide, its precursor and derivant of 0.1-20% and 0.02 to 2% diethylene-triamine pentaacetic acid (DTPA).

Above-mentioned preparation of the present invention can comprise additive and/or the skin/beneficial agent in the other personal cleansing preparation that is generally used for this type of.

Find surprisingly by the present invention, in the above-mentioned soap base preparation that contains nicotiamide optionally in conjunction with DTPA can avoid being used for the EDTA commonly used of trace Fe/Cu and EHDP chelating agen the storage stability that can not realize or control and the problem of variable color.

Therefore according to a preferred aspect of the present invention, the personal cleansing cleanser compositions is provided, and it comprises the cleaning agent active component of 15-85%, the nicotiamide of 0.1-20%, 0.02 the chelating agen of diethylene-triamine pentaacetic acid to 2% (DTPA) and 0.2-0.8%.

According to preferred aspect, even discovery in containing the soap preparation of nicotiamide in conjunction with DTPA and EHDP provide surprising under wet heat condition also improved storage stability, and the active component nicotiamide that comprises aequum be provided and do not existed in the preparation method that the soap class of any discoloration problem is arranged when storing.

Therefore according to this preferred aspect of the present invention, the personal cleansing cleanser compositions is provided, and it comprises the cleaning agent active component of 15-85%, the nicotiamide of 0.1-20%, 0.02 diethylene-triamine pentaacetic acid to 2% (DTPA) and 0.2-0.8% ethylidene hydroxyl diphosphate (EHDP).

According to another aspect of the present invention, provide the method for preparing the personal cleansing cleanser compositions, comprised optionally providing:

I) the cleaning agent active component of 15-85%;

The ii) skin lightening agent that is selected from nicotinic acid, nicotiamide, its precursor and derivant of 0.1-20%;

The DTPA of 0.02-2% iii) optionally is provided, has or do not have other typical additives simultaneously, preferred sequestrant;

And obtain the soap class by above-mentioned substance.

Preferred especially employed chelating agen is EHDP.

According to another preferred aspect of the present invention, the method for preparing the personal cleansing cleanser compositions is provided, comprising:

-soap noodles is provided according to conventional methods, and mix nicotiamide and described DTPA and EHDP, DTPA and EHDP before the nicotiamide adding and/or nicotiamide add fashionable being added into, thereby obtain stable soap class.

According to a further aspect of the invention, the enhanced stable storing system of using for cleaning agent/soap preparation of sending of skin lightening agent nicotiamide is provided, wherein this system comprises the active component of 15-85%, the skin lightening agent nicotiamide of 0.1-20%, the DTPA of 0.02-2% and the EHDP of 0.2-0.8%, and other optional beneficial agent/additive, wherein skin lightening agent nicotiamide is incorporated in the soap 20-60 ℃ temperature.

Therefore might come effectively and advantageously provide soap class by the present invention, even it also has storage stability and do not have discoloration problem under moist and pasty state condition with skin benefit agent nicotiamide.Importantly, preparation of the present invention will solve stability problem, this problem can not realize by the EDTA/EHDP commonly used that use is used to be sequestered in the trace Fe/Cu that the soap apoplexy due to endogenous wind exists, and helps the combination of nicotiamide stable storing in deriving from the soap of unsaturated fatty acid.

Selected brilliant white agent can be selected from nicotinic acid, nicotiamide, its precursor or derivant.Randomly, preparation can comprise other beneficial agent such as intacellin; Hydroquinone and derivant thereof (as arbutin); Kojic acid; Omega-dicarboxylic acids (Azelaic Acid, decanedioic acid) by formula HOOC-(CxHy)-COOH (wherein x=4 to 20, y=6 to 40) expression; Ascorbic acid and derivant thereof; Hydroxy acid or its ester (lactic acid, hydroxyacetic acid, malic acid, tartaric acid, citric acid or the like); Ferulic acid retinol and derivant thereof or any other known skin lightening agent.Above-mentioned skin lightening agent also can be introduced into large crumb (macro domains) form during mold pressing.

The soap class of using in the preparation can comprise the soap class that contains the unsaturated fatty acids material.The salt of term " soap class " expression carboxylic acids fatty acid.The soap class can derive from any in soap class preparation normally used triglyceride, so the carboxylate anion of soap apoplexy due to endogenous wind can contain 8-22 carbon atom.

The soap class can obtain by the saponification of fat and/or fatty acid.The fat or the oils that are generally used for the preparation of soap class can be such as tallow, tallow tristearin, Petiolus Trachycarpi oil, palm stearin, Oleum Glycines, fish oil, Oleum Ricini, Testa oryzae oil, Oleum helianthi, Oleum Cocois, babassu oil, palm-kernel oil and other material.In said method, fatty acid derives from and is selected from following oils/lipid: Cortex cocois radicis, Testa oryzae, Semen arachidis hypogaeae, tallow, Petiolus Trachycarpi, palm kernel, cotton seed, Semen sojae atricolor, Semen Ricini etc.The fatty acid soaps class also can be by synthetic making (as by the oxidation of oil or by Fischer-Tropsch building-up process (Fischer-Tropsch process)).Can use Resin Acid, as be present in the tall oil those.Aphthenic acids also is fit to.

The tallow fatty acid can derive from various animal origins, and generally includes the oleic acid of the palmitoleic acid of the stearic acid of the Palmic acid of the myristic acid of about 1-8%, about 21-32%, about 14-31%, about 0-4%, about 36-50% and the linoleic acid of about 0-5%.Typically be assigned as 2.5% myristic acid, 29% Palmic acid, 23% stearic acid, 2% palmitoleic acid, 41.5% oleic acid and 3% linoleic acid.Also can comprise other similar mixture, as derive from palmitic those and derive from those of various tallows and Adeps Sus domestica.

Oleum Cocois be meant have approximate 8%C8,7%C10, the fatty acid mixt of the carbon chain length distribution of 48%C12,17%C14,8%C16,2%C18,7% oleic acid and 2% linoleic acid (it is saturated that listed the first six planted fatty acid).Other has the source of similar carbon chain length distribution such as palm-kernel oil and babassu oil and is also included within the definition of term " Oleum Cocois ".

Can be in conjunction with optional beneficial agent, as organic sunscreen, Parsol MCX (registration goods is called Givaudan Roure, chemistry 2-ethyl-hexyl by name-Methoxycinnamate), Parsol1789 (chemistry butyl methoxy benzoylmethane by name).Also can be in conjunction with other beneficial agent, it is optional from wetting agent, emollient, wetting agent, on-soap surfactant, antibacterial and aging resistance chemical compound.

The on-soap surfactant can be the surfactant of anion, nonionic, cation, both sexes/amphoteric ion type, or their mixture.

The suitable heat preserving agent and the example of wetting agent comprise polyhydric alcohol, glycerol, spermol, carbopol 934 (carbopol 934), ethoxylated castor oil, paraffin oil, lanoline and derivant thereof.Also can comprise silicone compounds such as silicone surfactant such as DC3225C (Dow Corning) and/or silicone emollients, silicone oil (DC 200Ex-Dow Corning).Preferably in the arbitrary step before grinding steps in conjunction with the described beneficial agent of 1-5%.Perhaps during mold pressing, introduce some these beneficial agent of large crumb form.

Can be in conjunction with other additive such as one or more water-insoluble particulate matters, as Talcum, Kaolin, polysaccharide such as starch or modified starch and cellulose.

Can be in conjunction with minor amounts of additives, as spice, colorant, antiseptic, opacifier and other conventional additives of 1 to 2 weight %.

The personal cleansing product can be formulated as several forms.An example of personal cleansing product is a soap bar, and its preparation process is described in this article.

The preparation of soap class can be: with the suitable blend neutralization of fatty acid, perhaps with the suitable blend saponification of oils, perhaps with the blend saponification of fatty acid and oils.The soap class can be transformed into the soap noodles that common water content is 12-18%, and adds the nicotiamide as basic skin benefit agent in the soap noodles of preparation like this.Having or do not having under the condition of EDTA, optionally DTPA and EHDP mix with soap noodles add nicotiamide in soap noodles before and/or when adding nicotiamide.Mix minor amounts of additives such as spice, colorant etc.

Preferably the skin lightening agent is joined in the sigma mixer and mixing, the temperature during mix stages is 20-60 ℃.The further process grinding of blended soap-like matter, mold pressing and impression are with the preparation soap bar.

Under the situation of the soap class for preparing from the oils saponification, after from soap-like matter, reclaiming glycerol, carrying out similar process.With the genuine soap spray drying reducing moisture, and the soap noodles that obtains of processing as previously discussed.

The suitable equipment that is used for the preparation of soap class is any equipment that is used for soap class/cleaning agent preparation, is preferably high shear and mediates mixer.Preferred mixer comprises colter mixer (ploughsharemixer), has the blender that the crank throw formula is mediated parts, wiped overlapping (multi-wiping overlap), single curve or both arms more.Double-arm kneading mixer can be overlapping or the tangent design.Perhaps, carry out in the combination of the present invention's spiral screw rod mixer container that can in conventional treatment, use or multihead metering pump/high shear mixer and spray dryer.

Detailed description of the present invention, its purpose and advantage are able to more detailed description by following non-restrictive illustrative.

Embodiment

In embodiment 1-7 (comparative example), prepared conventional soap class cleaning compositions, wherein the soap apoplexy due to endogenous wind at the conventional Fe/Cu chelating agen of the EHDP of EDTA that comprises 0.02-0.2% and 0.2-1% combines the skin lightening agent nicotiamide that changes in the 0.1-5% scope.Details are as follows for method.

Prepare the personal cleansing soap composition by conventional method and obtained 78% total fatty matter.The soap class is become the soap noodles that water content is 12-18%, and in the soap noodles of preparation like this, sneak into the EHDP of nicotiamide, 0.2-1% and the EDTA of 0.02-0.2%.Then, add the nicotiamide that its amount changes in 0.1% to 5% scope, and in sigma mixer, mix at 40 ℃.The grinding of blended then soap process, mold pressing and impression are with the preparation soap bar.The EDTA that uses in the soap is the EDTA-4Na form, and its in soap on be limited to 0.02% (35% solution), be limited to 0.8% (60% solution) on the EHDP.Be limited to 0.5% on the DTPA.

The various amounts of the active nicotiamide that uses in soap base describe in detail in following table I.

Table I

Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)
Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)	1	0.1	0	0.2-1	0.02-0.2
2	0.5	0	0.2-1	0.02-0.2	1	0.1	0	0.2-1	0.02-0.2
2	0.5	0	0.2-1	0.02-0.2	3	1	0	0.2-1	0.02-0.2
4	2	0	0.2-1	0.02-0.2	3	1	0	0.2-1	0.02-0.2
4	2	0	0.2-1	0.02-0.2	5	3	0	0.2-1	0.02-0.2
6	4	0	0.2-1	0.02-0.2	5	3	0	0.2-1	0.02-0.2
6	4	0	0.2-1	0.02-0.2	7	5	0	0.2-1	0.02-0.2

Under 35-40 ℃ wet condition, tested the storage stability of the soap preparation of the above-mentioned ferrum/copper chelator EHDP/EDTA that combines nicotiamide and use always.In all above-mentioned soap preparations, observing metachromatism after 40-50 days.

The above results clearlys show that the conventional EDTA/EHDP of the trace Fe/Cu that is generally used for the existence of chelating soap apoplexy due to endogenous wind can not avoid the discoloration problem in containing the preparation of nicotiamide.Therefore this has proved conclusively the problem that nicotiamide basis soap class realizes the storage stability that product is required and keeps consumer attributes.

Embodiment 8-21

Among the embodiment 8-14 below, obtained to contain with the bonded selective d TPA of EHDP but without any the selective preparation of the present invention of EDTA, described preparation contains the active component nicotiamide just like the varying number of embodiment institute usage quantity in the Table I.

The amount of the amount of nicotiamide, DTPA and EHDP is reproduced in following table H, and reproduces in the amount infra Table III of EDTA.

Table II

Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)
Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)	8	0.1	0.02-0.5	0.2-0.8	0
9	0.5	0.02-0.5	0.2-0.8	0	8	0.1	0.02-0.5	0.2-0.8	0
9	0.5	0.02-0.5	0.2-0.8	0	10	1	0.02-0.5	0.2-0.8	0
11	2	0.02-0.5	0.2-0.8	0	10	1	0.02-0.5	0.2-0.8	0
11	2	0.02-0.5	0.2-0.8	0	12	3	0.02-0.5	0.2-0.8	0
13	4	0.02-0.5	0.2-0.8	0	12	3	0.02-0.5	0.2-0.8	0
13	4	0.02-0.5	0.2-0.8	0	14	5	0.02-0.5	0.2-0.8	0

Table III

Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)
Embodiment	Nicotiamide (%)	DTPA(％)	EHDP(％)	EDTA(％)	15	0.1	0.02-0.5	0.2-0.8	0.02
16	0.5	0.02-0.5	0.2-0.8	0.02	15	0.1	0.02-0.5	0.2-0.8	0.02
16	0.5	0.02-0.5	0.2-0.8	0.02	17	1	0.02-0.5	0.2-0.8	0.02
18	2	0.02-0.5	0.2-0.8	0.02	17	1	0.02-0.5	0.2-0.8	0.02
18	2	0.02-0.5	0.2-0.8	0.02	19	3	0.02-0.5	0.2-0.8	0.02
20	4	0.02-0.5	0.2-0.8	0.02	19	3	0.02-0.5	0.2-0.8	0.02
20	4	0.02-0.5	0.2-0.8	0.02	21	5	0.02-0.5	0.2-0.8	0.02

What obtain according to the present invention contains nicotiamide and has the DTPA of embodiment 8-14,15-21 and the identical storage stability test that exemplary formulation experiences then with preparation experienced shown in the Table I of EHDP combination in soap.

In all exemplary formulation of the present invention of embodiment 8-14 and 15-21, even variable color does not take place under 35-40 ℃ wet condition yet.

Below clearly and proved in the soap base personal wash compositions optionally benefit amply in conjunction with DTPA and EHDP combination (have and do not have EDTA), it makes it possible to the skin benefit agent nicotiamide in conjunction with 0.1-5%, and does not have any discoloration problem of soap class.

DTPA and EHDP are to the explanation of the benefit of variable color

Mainly comprise the nicotiamide of sodium oleate soap and 5%, and comprise that the soap preparation of the EHDP (embodiment 23) of the EHDP (embodiment 22) of 0.04% DTPA and 0.2% or 0.04% EDTA and 0.2% at room temperature stores 1-3 week.In not having the soap class sample of DTPA and containing the variable color that obtains in the preparation of the present invention of DTPA as shown in Figure 1.

Even the sample of embodiment 22 also is transparent (Figure 1A) after storing for 3 weeks, but another control sample of embodiment 23 even after storing for 1 week, significant variable color (Figure 1B) just takes place, and after 2 weeks, become poorer (Fig. 1 C).

Therefore might avoid soap class, the particularly personal cleansing preparation discoloration problem of (comprise and derive from unsaturated fatty acid and the bonded soap class of skin lightening agent nicotiamide) by the present invention.Therefore compositions of the present invention makes it possible to use the conventional preparation method of soap base detergent compositions on the one hand, particularly makes it possible to obtain to be used for strengthening sending of skin lightening agent nicotiamide and does not have the product variable color and/or owing to make the consumer attributes of product lose the composition/system of problem in the existence of the nicotiamide of this basic preparation.

Therefore compositions of the present invention will help in soap class/personal wash compositions widely and effective use/application skins based upon bidding brilliant white agent nicotiamide, and avoid in this kind cosmetics/personal cleansing product the restriction to the favourable use of nicotiamide.

Claims

1. personal cleansing/the cleanser compositions of stable storing, it comprises the cleaning agent active component that comprises the soap class of 15-85%, the skin lightening agent that is selected from nicotinic acid and nicotiamide of 0.1-20% and 0.02% to 2% diethylene-triamine pentaacetic acid (DTPA).

2. personal cleansing/the cleanser compositions of the stable storing of claim 1 further comprises the chelating agen of 0.2-0.8%.

3. personal cleansing/the cleanser compositions of claim 1 or 2 stable storing comprises the ethylidene hydroxyl diphosphate (EHDP) of 0.2-0.8%.

4. personal cleansing/the cleanser compositions of claim 1 or 2 stable storing comprises other conventional additives and/or skin benefit agent.

5. personal cleansing/the cleanser compositions of the stable storing in the claim 4, wherein other beneficial agent comprises: intacellin; Hydroquinone; Kojic acid; By the omega-dicarboxylic acids that formula HOOC-(CxHy)-COOH represents, x=4-20 wherein, y=6-40; Hydroxy acid or its ester; The known skin lightening agent of retinol and other routine.

6. personal cleansing/the cleanser compositions of the stable storing in the claim 5, wherein this other beneficial agent is selected from Azelaic Acid, decanedioic acid, ascorbic acid and ferulic acid.

7. personal cleansing/the cleanser compositions of the stable storing in the claim 5, wherein hydroxy acid or its ester are selected from lactic acid, hydroxyacetic acid, malic acid, tartaric acid and citric acid.

8. personal cleansing/the cleanser compositions of claim 1 or 2 stable storing, wherein the skin lightening agent is introduced into the large crumb form during mold pressing.

9. personal cleansing/the cleanser compositions of claim 1 or 2 stable storing, wherein used soap class comprises the soap class that contains the unsaturated fatty acids material in the preparation.

10. personal cleansing/the cleanser compositions of the stable storing of claim 4, wherein beneficial agent is selected from organic sunscreen agent, wetting agent, emollient, wetting agent, antibacterial and aging resistance chemical compound.

11. the personal cleansing/cleanser compositions of the stable storing of claim 4, wherein beneficial agent is selected from the on-soap surfactant.

12. the personal cleansing/cleanser compositions of the stable storing in the claim 10, wherein the organic sunscreen agent is 2-ethyl-hexyl-Methoxycinnamate or butyl methoxy benzoylmethane.

13. the personal cleansing/cleanser compositions of the stable storing of claim 10 comprises being selected from following on-soap surfactant: the surfactant of anion, nonionic, cation, both sexes or amphoteric ion type and their mixture.

14. the personal cleansing/cleanser compositions of the stable storing of claim 4 is included in the arbitrary step before the grinding steps beneficial agent in conjunction with 1-5%.

15. the beneficial agent of the large crumb form that optionally provides during the mold pressing is provided the personal cleansing/cleanser compositions of the stable storing of claim 4.

16. the personal cleansing/cleanser compositions of the stable storing of claim 4, wherein additive is selected from one or more water-insoluble particulate matters.

17. the personal cleansing/cleanser compositions of the stable storing of claim 16, wherein the water-insoluble particulate matter is selected from Talcum, Kaolin or comprises starch or modified starch or cellulosic polysaccharide.

18. the personal cleansing/cleanser compositions of the stable storing of claim 1 or 2 comprises a small amount of additive, described a small amount of additive is spice, colorant, antiseptic, opacifier and other conventional additives of 1 to 2 weight %.

19. be used for the personal cleansing/cleanser compositions of the stable storing that the enhancing skin lightening agent nicotiamide of cleaning agent/soap preparation sends, wherein said composition comprises the cleaning agent active component that comprises the soap class of 15-85%, the skin lightening agent that is selected from nicotinic acid and nicotiamide of 0.1-20%, the DTPA of 0.02-2% and the EHDP of 0.2-0.8%, and wherein skin lightening agent nicotiamide is incorporated in the soap 20-60 ℃ temperature.

20. the personal cleansing/cleanser compositions of the stable storing of claim 19, wherein said composition comprises other beneficial agent or additive.

21. prepare the method for personal cleansing cleanser compositions, comprise providing:

I) the cleaning agent active component that comprises the soap class of 15-85%;

The ii) skin lightening agent that is selected from nicotinic acid and nicotiamide of 0.1-20%;

The iii) DTPA of 0.02-2%; And

Obtain compositions by above-mentioned substance.

22. the method for claim 21 comprises the conventional additives in conjunction with other, it is the chelating agen that reaches 0.2-0.8%.

23. the method for claim 22, wherein said chelating agen are EHDP.

24. the method for claim 23 comprises:

-soap noodles is provided according to conventional methods, and mix nicotiamide and described DTPA and EHDP, described DTPA and EHDP add fashionable being added into before described nicotiamide adds and/or at nicotiamide, thereby obtain stable compositions.

25. each method among the claim 21-23, wherein the skin lightening agent is added in the sigma mixer and mixes, and the temperature during mix stages is 20-60 ℃, and the further process grinding of blended soap-like matter, mold pressing and impression are with the preparation soap bar.

26. the method for claim 25 is included in the arbitrary step before the grinding steps beneficial agent in conjunction with 1-5%.

27. the method for claim 25 is included in the beneficial agent that the large crumb form optionally is provided during the mold pressing.

28. the method for claim 24, comprise by with the suitable blend neutralization of fatty acid or by preparing the soap class with the suitable blend saponification of oils or by blend saponification with fatty acid and oils, the soap class is transformed into the soap noodles that water content is 12-18%, and in this soap noodles of preparation like this, add nicotinoyl amido skin benefit agent, wherein be with or without under the condition of EDTA, before in soap noodles, adding nicotiamide and/or at nicotiamide, adding and fashionable DTPA and EHDP are sneaked into soap noodles.

29. each method among the claim 21-23, use therein soap-like matter is made by the oils saponification, and reclaims glycerol from soap-like matter before being used for this method.