CN1883565A - Gel for treating rheumatic arthritis and traumatic injury and method for preparing same - Google Patents
Gel for treating rheumatic arthritis and traumatic injury and method for preparing same Download PDFInfo
- Publication number
- CN1883565A CN1883565A CN 200610083420 CN200610083420A CN1883565A CN 1883565 A CN1883565 A CN 1883565A CN 200610083420 CN200610083420 CN 200610083420 CN 200610083420 A CN200610083420 A CN 200610083420A CN 1883565 A CN1883565 A CN 1883565A
- Authority
- CN
- China
- Prior art keywords
- gel
- radix
- examples
- glycerol
- carbomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000003068 rheumatic fever Diseases 0.000 title claims description 11
- 208000014674 injury Diseases 0.000 title abstract description 9
- 230000008736 traumatic injury Effects 0.000 title abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 29
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 8
- 229960001631 carbomer Drugs 0.000 claims abstract description 8
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 8
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000758 substrate Substances 0.000 claims abstract description 5
- 206010024453 Ligament sprain Diseases 0.000 claims description 13
- 208000010040 Sprains and Strains Diseases 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 230000002421 anti-septic effect Effects 0.000 claims description 5
- 238000005325 percolation Methods 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 244000173166 Pyrus ussuriensis Species 0.000 claims description 2
- 235000011572 Pyrus ussuriensis Nutrition 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 18
- 230000036407 pain Effects 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000470 constituent Substances 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 240000000233 Melia azedarach Species 0.000 abstract 1
- 235000003143 Panax notoginseng Nutrition 0.000 abstract 1
- 241000180649 Panax notoginseng Species 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 17
- 230000008961 swelling Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010014080 Ecchymosis Diseases 0.000 description 5
- 206010042674 Swelling Diseases 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 210000003797 carpal joint Anatomy 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 240000005373 Panax quinquefolius Species 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 210000000544 articulatio talocruralis Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002310 elbow joint Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000000323 shoulder joint Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a gelling agent for treating rheumatism, knuckle pain, traumatic injury and contused wound, which is prepared from effective constituents and right gel substrate material, humectant and preservative agent, the effective constituents include Chinese medicinal herbs including chinaberry bark, panicled swallowwort root and water notoginseng, the preservative agent is preferably selected from carbomer, glycerin and ethylparaben. The invention also discloses the process for preparing the medicament.
Description
Technical field
The present invention relates to a kind of gel for the treatment of rheumatic arthritis, traumatic injury, sprain and contuse, the invention still further relates to the preparation method of this gel.
Background technology
Diseases such as rheumatic arthritis, traumatic injury, sprain and contuse belong to " numbness " disease on the traditional Chinese medical science, be because of " wet three gas of wind and cold are assorted extremely, close and are numbness, and its pathogenic wind Sheng person is a migratory arthralgia; Cold Sheng person is an arthralgia aggravated by cold; Dampness Sheng person damp arthralgia also ".Illustrated that the wet heresy of wind and cold all can cause " numbness " disease.The traditional Chinese medical science is thought " stagnation of QI and blood may bring about pain ", and points out " numbness person closes also ".When exopathogen when the flesh table is invaded limbs, it stays in the flesh natural fibre line of meat, meridians, joint etc. and locates, and makes QI-blood circulation not smooth, blockage of main and collateral channels, stagnation of QI and blood may bring about pain.
At present, the chemicals of treatment rheumatic arthritis, traumatic injury, sprain and contuse mainly contains nonsteroidal antiinflammatory drug and glucocorticoid.But these adverse effectes are many, and patient's compliance is relatively poor, unsuitable life-time service.
" rheumatic bone-setting tincture " records in " national standard for traditional Chinese medicines compilation " orthopedics department fascicle.Effect with expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain is the pure Chinese medicinal preparation of treatment rheumatic arthritis, traumatic injury, the caused waist lower limb of sprain and contuse, joint, muscle flesh pain.Form Radix dactylicapni (Radix Dactylicapnotis) analgesia, hemostasis in the side by four Chinese medicines such as Radix dactylicapni (Radix Dactylicapnotis), Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cynanchi Paniculati, SHUISANQI; Ramulus et Folium Pcrasmae (Cortex Picrasmae) heat clearing and damp drying, detoxifcation; The Radix Cynanchi Paniculati removing dampness of dispeling the wind, antalgesic-antipruritic; SHUISANQI hemostasis dissipating blood stasis, removing toxic substances and promoting subsidence of swelling.All medicines share, and play the effect of expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain altogether.This medicine is through clinical verification for many years, determined curative effect, no obvious toxic-side effects.But this medicine is a liquid preparation, runs off easily at agents area, and the local holdup time is short, influences the normal performance of curative effect of medication, and uses, preserves, transports also inconvenient.And we are rheumatic bone-setting gel dosage form with its research and development, and the rheumatic bone-setting gel adopts hydrophilic gel substrate to make good looking appearance; Strong in the lesion tack, can overcome the deficiency of tincture in the volatile loss of agents area, prolong action time; Be easy to coating and use, smear the no foreign body sensation in back; Good with the skin coupling, to mucocutaneous non-stimulated; No greasy feeling, pollution clothes not, easy cleaning after the medication; Preparation technology is simple; Have good stability; Carry, store, transportation etc. is more convenient.
Summary of the invention
One of purpose of the present invention provides a kind of gel for the treatment of rheumatic arthritis, traumatic injury, sprain and contuse disease.
Another object of the present invention provides the preparation method of this gel.
Gel of the present invention, be made up of active ingredient and suitable substrate, wetting agent, the antiseptic of making gel, described active ingredient is made up of the component of following weight proportion: Radix dactylicapni (Radix Dactylicapnotis) 100-200, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 100-200, Radix Cynanchi Paniculati 15-35, SHUISANQI 15-35:
The described suitable substrate of making gel is selected from one or more in carbomer, chitosan, polyvinyl alcohol, guar gum, arabic gum, hydroxypropyl methylcellulose, the sodium carboxymethyl cellulose etc.;
Described wetting agent is selected from one or more in glycerol, Polyethylene Glycol, sorbitol, the glycerol etc.;
Described antiseptic is selected from one or more in ethyl hydroxybenzoate, benzoic acid, sorbitol, the Pyrusussuriensis potassium alcoholate etc.
Gel of the present invention, preferred weight proportion is: Radix dactylicapni (Radix Dactylicapnotis) 150, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 150, Radix Cynanchi Paniculati 25, SHUISANQI 25, carbomer 10-40, glycerol 10-40, ethyl hydroxybenzoate 1-4.
The preparation method of gel of the present invention is: take by weighing Radix dactylicapni (Radix Dactylicapnotis), Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cynanchi Paniculati, SHUISANQI, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), make solvent with Diluted Alcohol, flood after 96 hours, at 18～25 ℃ with the speed of per minute 1～3ml percolation slowly, collect percolate, left standstill 24 hours, and filtered, it is an amount of to get carbomer, add in the medicinal liquid, stirring makes dissolving, adds glycerol, ethyl hydroxybenzoate again, mends to full dose with Diluted Alcohol, stir evenly, promptly.
The specific embodiment
Embodiment 1
Take by weighing Radix dactylicapni (Radix Dactylicapnotis) 150g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 150g, Radix Cynanchi Paniculati 25g, SHUISANQI 25g, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), make solvent with Diluted Alcohol, flood after 96 hours, at 18～25 ℃ with the speed of per minute 1～3ml percolation slowly, collect the about 1000ml of percolate, left standstill 24 hours, and filtered, carbomer is got 20g, add in the medicinal liquid, stirring makes dissolving, adds glycerol 20g, ethyl hydroxybenzoate 2g again, mends to 1000g with Diluted Alcohol, stir evenly, promptly.
Clinical trial example 1
Be the definite safety of estimating clinical efficacy of the present invention and medicine, the present invention sums up rheumatic arthritis patient 235 examples, articular sprain patient 44 examples respectively in practical clinical, be effective case and receive significant curative effect.Do not find any toxic and side effects, now the clinical trial situation is summarized as follows.
Test example 1 medicine of the present invention is to the therapeutical effect of rheumatic arthritis
Concrete clinical trial protocol is:
Clinical data:
This group is totally 235 examples, male's 93 examples wherein, women's 142 examples; Age 20-30 year 54 examples, 31-40 year 62 examples, 41-50 year 56 examples, 51-60 year 37 examples, person's 26 examples more than 61 years old.Clinical symptoms: migration pain person 166 examples, localized pain person 47 examples, joint stuffiness person 23 examples, the part person of feeling cold 56 examples, the many pains of acid are lacked person's 97 examples, arthroncus person's 76 examples.Site of pathological change: shoulder joint 74 examples, elbow joint 62 examples, knee joint 99 examples.Lab testing: above person's 214 examples of erythrocyte sedimentation rate 20mm/h, anti-above person's 222 examples of " O " 500u.
Therapeutic Method:
External earlier use the warm water cleaning affected part, after getting gel that the embodiment of the invention prepares and being applied to the affected part, firmly rubs 15 minutes.1-2 time on the one, 12 weeks were a course of treatment.This is organized 235 examples and all is coated with 1 course of treatment.
Curative effect judging standard:
Recovery from illness: arthralgia disappears, and functional rehabilitation is normal, and erythrocyte sedimentation rate, anti-" O ", the every laboratory indexes of rheumatoid factor all recover normal;
Produce effects: arthralgia disappears substantially, but slight sense of discomfort is arranged, and it is normal or approaching normal that erythrocyte sedimentation rate, anti-" O ", the every laboratory indexes of rheumatoid factor all recover;
Effectively: clinical symptoms and laboratory indexes take a favorable turn other no significant changes before the treatment;
Invalid: state of an illness no change before and after the treatment.
Therapeutic outcome:
Recovery from illness: person's 61 examples account for 26.0%;
Produce effects: person's 81 examples account for 34.5%;
Effectively: person's 78 examples account for 33.2%:
Invalid: person's 15 examples account for 6.4%.
Total effective rate is 93.6%, and all cases are not all found obvious toxic and side effects in therapeutic process.
Test example 2 medicines of the present invention are to traumatic injury, the effect of sprain and contuse treatment of diseases
Concrete clinical trial protocol is:
Clinical data:
This organizes 44 examples, male 26 examples, women 18 examples, age 10-40 year, course of disease 1-5 days.Sprain of carpal joint 12 examples, sprained ankle 32 examples.All cases are the outpatient, and tangible ankle joint, sprain of carpal joint history are arranged.Damage back ankle joint, carpal joint limited, the damage location of pain, swelling, ecchymosis, joint motion suddenly have tangible pressure pain point.X-ray film is not seen fracture.
Therapeutic Method:
External earlier use the warm water cleaning affected part, after getting gel that the embodiment of the invention prepares and being applied to the affected part, firmly rubs 15 minutes (bruise acute stage avoid rub).1-2 time on the one, a course of treatment 2 Mondays.This is organized 44 examples and all is coated with 1 course of treatment.
Curative effect judging standard:
Recovery from illness: pain, swelling, ecchymosis disappear, the position of damage does not have pressure pain point, joint motion is normal;
Produce effects: the position pressure pain point that pain, swelling, ecchymosis disappear substantially, damage is not obvious, can walk but have when walking for a long time uncomfortable sensation maybe can carry thing but ache when bearing a heavy burden;
Effectively: mild pain when there is mild tenderness at the position that pain, swelling, ecchymosis obviously alleviate, damage, walks or carries thing;
Invalid: it is limited that pain, swelling, ecchymosis do not have the position tenderness, the joint motion that alleviate, damage.
Therapeutic outcome:
Recovery from illness: 23 examples account for 52.3%:
Produce effects: 13 examples account for 29.5%;
Effectively: 6 examples account for 13.6%;
Invalid: 2 examples account for 4.5%.
Total effective rate is 95.5%, and all cases are not all found apparent side effect in therapeutic process.
Comprehensive above clinical experiment example, the medicine of the present invention's preparation is safe and effective aspect treatment rheumatic arthritis, traumatic injury, sprain and contuse disease.
Claims (4)
1. gel for the treatment of rheumatic arthritis, osteopatia sprain, it is characterized in that being made up of active ingredient and suitable substrate and the adjuvant of making gel, the weight proportion of each component is: Radix dactylicapni (Radix Dactylicapnotis) 100-200, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 100-200, Radix Cynanchi Paniculati 15-35, SHUISANQI 15-35, gel-type vehicle 10-40, wetting agent 10-40, antiseptic 1-4.
2. the described gel of claim 1 is characterized in that described gel-type vehicle is selected from one or more in carbomer, chitosan, polyvinyl alcohol, guar gum, arabic gum, hydroxypropyl methylcellulose, the sodium carboxymethyl cellulose etc.;
Described wetting agent is selected from one or more in glycerol, Polyethylene Glycol, sorbitol, the glycerol etc.;
Described antiseptic is selected from one or more in ethyl hydroxybenzoate, benzoic acid, sorbitol, the Pyrusussuriensis potassium alcoholate etc.
3. gel according to claim 1 is characterized in that the preferred weight proportioning of described active ingredient and gel-type vehicle, wetting agent, antiseptic is: Radix dactylicapni (Radix Dactylicapnotis) 150, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 150, Radix Cynanchi Paniculati 25, SHUISANQI 25, carbomer 10-40, glycerol 10-40, ethyl hydroxybenzoate 1-4.
4. the preparation method of the described gel of claim 1 is characterized in that: take by weighing Radix dactylicapni (Radix Dactylicapnotis), Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cynanchi Paniculati, SHUISANQI, make solvent with Diluted Alcohol, flood after 96 hours, 18～25 ℃ with the speed of per minute 1～3ml percolation slowly, collect percolate, left standstill 24 hours, and filtered, it is an amount of to get carbomer, add in the medicinal liquid, stirring makes dissolving, adds glycerol, ethyl hydroxybenzoate, mends to full dose with Diluted Alcohol, stir evenly, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610083420 CN1883565A (en) | 2006-05-31 | 2006-05-31 | Gel for treating rheumatic arthritis and traumatic injury and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610083420 CN1883565A (en) | 2006-05-31 | 2006-05-31 | Gel for treating rheumatic arthritis and traumatic injury and method for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1883565A true CN1883565A (en) | 2006-12-27 |
Family
ID=37581947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610083420 Pending CN1883565A (en) | 2006-05-31 | 2006-05-31 | Gel for treating rheumatic arthritis and traumatic injury and method for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1883565A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658555B (en) * | 2009-09-23 | 2011-11-23 | 沈阳亿灵医药科技有限公司 | Rheumatic bone-setting transdermal patch and preparation process thereof |
| CN102600232A (en) * | 2012-04-10 | 2012-07-25 | 何平清 | Chinese herbal medicine for treating fracture and hamstringing |
| CN104606642A (en) * | 2015-02-09 | 2015-05-13 | 山东大学齐鲁医院 | Gel for treating traumatic injury and preparation method of gel |
-
2006
- 2006-05-31 CN CN 200610083420 patent/CN1883565A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658555B (en) * | 2009-09-23 | 2011-11-23 | 沈阳亿灵医药科技有限公司 | Rheumatic bone-setting transdermal patch and preparation process thereof |
| CN102600232A (en) * | 2012-04-10 | 2012-07-25 | 何平清 | Chinese herbal medicine for treating fracture and hamstringing |
| CN104606642A (en) * | 2015-02-09 | 2015-05-13 | 山东大学齐鲁医院 | Gel for treating traumatic injury and preparation method of gel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103961636B (en) | Orthopedic disease treatment external application traditional Chinese medicine composition, preparation method and application thereof | |
| CN101214286A (en) | Chinese medicine white spirit preparations for effectively treating rheumatic pain diseases | |
| CN101843873B (en) | Muscle-nourishing bone-strengthening ointment | |
| CN102302661B (en) | One treats dermopathic Chinese medicine composition | |
| CN100496544C (en) | Chinese medicine preparation for treating pains and its preparing method and use | |
| CN1129135A (en) | Swelling-diminishing pain-relieving tincture | |
| CN1883565A (en) | Gel for treating rheumatic arthritis and traumatic injury and method for preparing same | |
| CN106963923A (en) | A kind of Chinese medicine composition and preparation method and application with analgesic activity | |
| CN1326546C (en) | Pure Chinese medicinal preparation for external treating burn and scald | |
| CN110787278B (en) | Traditional Chinese medicine external application plaster for treating tenosynovitis and preparation method thereof | |
| CN1899471A (en) | External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method | |
| CN102293880B (en) | External Chinese herbal preparation for treating bedsore and preparation method thereof | |
| CN102357215A (en) | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis | |
| CN101703667A (en) | Brown red medicament for treating traumatic injuries and preparation method thereof | |
| CN1695682A (en) | External use preparation for treating rheumatisma and bone injuries | |
| CN111759905A (en) | Cataplasm for treating osteoarthritis and preparation method thereof | |
| CN1883592A (en) | Gel for treating rheumatism and headache and method for preparing same | |
| CN114886981B (en) | Traditional Chinese medicine composition and application thereof in preparation of neck-shoulder lumbocrural pain medicines | |
| CN103655768A (en) | Traditional Chinese medicine for treating clod-dampness gonitis, and preparation method thereof | |
| CN1134819A (en) | Analgesic adhesive made of Chinese herb medicines | |
| CN107137677A (en) | Warm sun patch | |
| CN102755487A (en) | Traditional Chinese medicine powder for eliminating dampness and invigorating blood circulation | |
| CN102552593A (en) | Chinese medicinal composition for treating wind-cold-dampness arthralgia and using method thereof | |
| CN101057951B (en) | Plaster for auxiliary curing rheumatoid disease and its preparing method | |
| CN107158126A (en) | A kind of anti-inflammatory analgetic composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Lijuan Document name: Written notice of preliminary examination of application for patent for invention |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Lijuan Document name: Notice of application for publication of patent for invention and entry into the substantive examination procedure |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |