CN1872085A - Compound tincture for treating acne - Google Patents
Compound tincture for treating acne Download PDFInfo
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- CN1872085A CN1872085A CN 200610043867 CN200610043867A CN1872085A CN 1872085 A CN1872085 A CN 1872085A CN 200610043867 CN200610043867 CN 200610043867 CN 200610043867 A CN200610043867 A CN 200610043867A CN 1872085 A CN1872085 A CN 1872085A
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- acne
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- erythromycin
- chloromycetin
- pimple
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Abstract
A compound tincture for treating pile is proportionally prepared from erythromycin, chloromycetin, mint oil, borneol, and the alcohol solution of glycerin.
Description
1, technical field
The present invention relates to a kind of medicine for the treatment of acne, specifically a kind of compound spirit for the treatment of acne.
2, background technology
Acne is the distinctive disease of adolescence, be because endocrine alteration causes that the sebaceous gland function is vigorous, sebum secretion strengthens, the while abnormal cornification of pilosebaceous duct, the epithelial cell that follicular wall comes off mixes the obstruction follicular orifice with sebum, form acne, and infection such as secondary propionibacterium acnes, the formation of skin lesion such as struvite pimple, pus kitchen caused.At present, mostly the clinical treatment method that is used for acne is to adopt skin surface to smear antiinflammatory, sterilization, antipruritic ointment, and its therapeutic effect is all not really desirable, is still the unsolved difficult problem of medical circle at present.
3, summary of the invention
The purpose of this invention is to provide the compound spirit that a kind of therapeutic effect is good, be free from side effects, have the treatment acne of bactericidal antiphlogistic, antipruritic, dispelling toxins and dredging collaterals, anti-acne granulation promoting beauty.
The objective of the invention is to realize in the following manner, the erythromycin in this prescription, chloromycetin have the collaborative effect that suppresses the propionibacterium acnes growth, thereby the source of disease bacterium of having removed inflammation.Erythromycin can promote leukocytic apoptosis simultaneously, influences its chemotaxis, influences the statement of some cytokine, and the generating process of inflammation-inhibiting has dual antiinflammatory action.Thereby reduce the formation of acne and struvite pimple, pustule.Ethanol in the solvent has fat-soluble, and the sebum in can the dissolved dilution follicular orifice is beneficial to the discharge of exfoliative cyte, reduces the chance of secondary infection.Glycerol is not volatile, mixes arbitrarily with water, ethanol, skin is had the effect of preserving moisture, moistening and prolonging local drug effect, and Borneolum Syntheticum and Oleum menthae have the effect of refreshing and detoxicating, skin protection.The pH value of this product=5.5 meet the chemical characteristic of skin, help the performance of the physiological function of skin; Existing therapeutical effect has the effect of protection skin again, than simple application ethanol, has reduced the drying of skin, nervous sense, and zest is little, and the patient is easy to accept, and has a extensive future.
5, embodiment
A kind of compound spirit for the treatment of acne of the present invention is made up of following materials of weight proportions: 100 parts of erythromycin 0.3-2.0 parts, chloromycetin 0.1-2.0 part, Oleum menthae 0.3-1.0 part, Borneolum Syntheticum 0.1-1 part, glycerol ethanol water;
Preparation process is as follows:
1) with 40 parts of glycerol, 50 parts of 75% ethanol, that 10 parts of mix homogeneously of distilled water are made the glycerol ethanol water is standby;
2) take by weighing erythromycin, chloromycetin, Borneolum Syntheticum in proportion and add in the glycerol ethanol water and stir, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, packing is finished product.
The present invention treats the compound spirit of acne, can also be made up of following materials of weight proportions: 100 parts of erythromycin 0.5-1.6 parts, chloromycetin 0.6-1.8 part, Oleum menthae 0.5-0.8 part, Borneolum Syntheticum 0.3-0.7 part, glycerol ethanol water.
The present invention treats the compound spirit of acne, can also be made up of following materials of weight proportions: 1.2 parts in erythromycin, 1.5 parts in chloromycetin, 0.7 part of Oleum menthae, 0.5 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters.
Embodiment 1, prescription: 0.3 part in erythromycin, 0.1 part in chloromycetin, 0.3 part of Oleum menthae, 0.1 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters;
Preparation process is as follows:
1) with 40 parts of glycerol, 50 parts of 75% ethanol, that 10 parts of mix homogeneously of distilled water are made the glycerol ethanol water is standby;
2) take by weighing erythromycin, chloromycetin, Borneolum Syntheticum in proportion and add in the glycerol ethanol water and stir, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, packing is finished product.
Embodiment 2, prescription: 2.0 parts in erythromycin, 2.0 parts in chloromycetin, 1.0 parts of Oleum menthae, 1 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters;
Preparation process is identical with embodiment 1.
Embodiment 3, prescription: 0.3 part in erythromycin, 0.4 part in chloromycetin, 0.3 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters.
Preparation process is identical with embodiment 1.
Embodiment 4, prescription: 0.5 part in erythromycin, 0.3 part in chloromycetin, 0.6 part of Oleum menthae, 100 parts of glycerol ethanol waters.
Preparation process is identical with embodiment 1.
Embodiment 5, prescription: 0.5 part in erythromycin, 0.6 part of Oleum menthae, 0.6 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters.
Preparation process is identical with embodiment 1.
Embodiment 5, prescription: 0.4 part in chloromycetin, 0.6 part of Oleum menthae, 0.3 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters.
Preparation process is identical with embodiment 1.
Case is selected:
Inclusion criteria: have typical clinical manifestation, meet the diagnostic criteria 1 of II level acne vulgaris, do not do any Drug therapy in January, do not have the other diseases of merging.
Rejecting standard: to this product allergy sufferers; Prolonged application corticosteroid hormone person; Symptomatic acne; Therapy discontinued and can not further consultation person.
MethodsThe cases enrolled: 60 routine MethodsThe cases enrolled are my outpatient of section.Wherein male 32 examples, women 28 examples, man: woman=1.14; The oldest 25 years old, minimum 12 years old, average 18.6 years old; The shortest 2 weeks of the course of disease, the longest 3 years.
The compound spirit of treatment acne of the present invention is hereinafter to be referred as " the sweet tincture of compound recipe chlorine ".
Medication and observational technique: dip in cotton swab and to get the sweet tincture of compound recipe chlorine for preparing, evenly be applied to the affected part, area is slightly larger than skin lesion, early, middle and late each once, one month course of treatment.Before treatment, 1 week of treatment back, 2 weeks, 3 all and 4 weeks carried out clinical score.The method of scoring be with clinical manifestation inflammation pimple, pus kitchen by not having-0, gently-1, in-2, heavy by-3, adding up after the scoring both is clinical score; Score * 100% before treatment back clinical improvements rate=(score before the treatment-treatment back score)/treatment.
Efficacy determination: adopt 4 grade standards
Recovery from illness clinical improvements rate 〉=95%
Produce effects clinical improvements rate＜95%, 〉=60%
Effective clinical improvements rate＜60%, 〉=20%
Invalid clinical improvements rate＜20%
Recovery from illness adds produce effects and adds up to effective percentage
Therapeutic outcome sees Table
| Recovery from illness (routine %) | Produce effects (routine %) | Effectively (routine %) | Invalid (routine %) | Effective percentage (%) | |
| Treatment 4 weeks of back in 1 week treatment back, treatment back, 2 week treatment, 3 week of back | 0(0.0) 5(8.3) 7(11.7) 8(13.3) | 20(33.3) 39(65.0) 43(71.7) 45(75.0) | 35(58.2) 13(21.7) 9(16.7) 6(10.0) | 5(8.3) 3(5.0) 1(1.7) 1(1.7) | 33.3 73.3 82.4 88.5 |
Side effect is observed
This group skin erythema occurs after 5 examples (8.3%) patient medication is arranged, excitement, but unprocessed spontaneous remission, and all therapy discontinued not finished until the course of treatment.
Model case
Case 1: gold is worn, woman, 16 years old, Sishui County Miao Guan town Huang Jia people from village.Facial red pimple, pus kitchen are gone to a doctor February, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level), the sweet tincture external of compound recipe chlorine, every day 3 times.Erythra obviously reduces after 1 week, the most of disappearance of 2 weeks, and 3 weeks fully recovered.
Case 2: Ma Yong, man, 19 years old, yellow people from city in holy water valley, Sishui County township.Facial red pimple, pus kitchen are gone to a doctor January, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level), the sweet tincture external of compound recipe chlorine, every day 3 times.1 week back erythra reduces, and 2 weeks continued to reduce, 3 weeks most of the disappearance, 4 weeks only residual 2 acne.
Case 3: Feng Guanghong, man, 16 years old, area just outside a city gate, Sishui County town Bao Cunren.Facial red pimple, pus kitchen are gone to a doctor October, have a medical check-up meeting portion more than 40 Semen phaseoli radiati grain size pimple, pus kitchen, a little acne, foxtail millet grain size.Diagnosis acne vulgaris (II level), the sweet tincture external of compound recipe chlorine, every day 3 times.Erythra obviously reduces after 1 week, 2 all most of disappearances, 3 all pimples, the whole disappearances of pus kitchen, residual grain of rice size acne.Miao Guan town, Sishui County Huang Jia people from village.Facial red pimple, pus kitchen are gone to a doctor February, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level), the sweet tincture external of compound recipe chlorine, every day 3 times.Erythra obviously reduces after 1 week, the most of disappearance of 2 weeks, and 3 weeks fully recovered.1, congratulate, the man, 17 years old, family's hall was congratulated in the star villages and small towns.Facial played acne, red pimple, pustule 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Case 4: Wang Qing, woman, 16 years old, Huang Gou township Xing family room.Facial played acne, red pimple, pustule 12 months, the treatment of once repeatedly going to a doctor, poor effect.Have a medical check-up meeting portion intensive grain of rice size blackhead and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, pustule obviously reduces after 1 week, and pimples reduce obviously after 2 weeks, and 3 all pustule pimples all disappear, and are dispersed in a little acne; 4 all erythra all disappear.
Case 5: Lee's wind, woman, 24 years old, area just outside a city gate fountain.A facial acne, red pimple 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, and acne subtract obviously few; 4 all acne all disappear.
Case 6: Zhang Lin, woman, golden Zhuan Geshan.A facial red pimple, pustule 6 months, have a medical check-up meeting portion intensive foxtail millet grain large red pimple, pustule are distributed symmetrically, and forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear.
Case 7: Jiang Shanshan, woman, 15 years old, willow river bend garden.Facial played acne, red pimple, pustule 8 months, more grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 2 weeks, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Case 8: Zhang Ping, woman, 14, nasal mucus Zhang Xiaoshan.A facial acne, red pimple 3 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, and are dispersed in a little acne.
Case 9: Chen Zhongyu, man, 15 years old, holy water valley river.Facial played acne, red pimple, pustule 5 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times.The back pustule disappearance of 1 week, pimple reduces; 2 all pimples all disappear, and are dispersed in a little acne.
Case 10: Li Na, man, 14 years old, middle volume Xiao Li.The facial acne, red pimple 1 year of rising are surplus, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, and forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, 4 all residual a little acne.
Case 11: Wang Hongwei, man, 20 years old, spring woods Liuhe.Facial played acne, red pimple, pustule 4 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 2 all pimples all disappear, and are dispersed in a little acne.
Case 12 Qiao Zhi send out, man, 16 years old, the Zhe Gouwei village.Facial played acne, red pimple, pustule 3 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, 4 all residual a little acne.
Case 13: congratulate, the man, 17 years old, family's hall was congratulated in the star villages and small towns.Facial played acne, red pimple, pustule 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).The sweet tincture external of compound recipe chlorine, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Claims (3)
1, a kind of compound spirit for the treatment of acne is characterized in that being made up of following materials of weight proportions: 100 parts of erythromycin 0.3-2.0 parts, chloromycetin 0.1-2.0 part, Oleum menthae 0.3-1.0 part, Borneolum Syntheticum 0.1-1 part, glycerol ethanol water;
Preparation process is as follows:
1) with 40 parts of glycerol, 50 parts of 75% ethanol, that 10 parts of mix homogeneously of distilled water are made the glycerol ethanol water is standby;
2) take by weighing erythromycin, chloromycetin, Borneolum Syntheticum in proportion and add in the glycerol ethanol water and stir, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, packing is finished product.
2, the compound spirit of treatment acne according to claim 1 is characterized in that being made up of following materials of weight proportions: 100 parts of erythromycin 0.5-1.6 parts, chloromycetin 0.6-1.8 part, Oleum menthae 0.5-0.8 part, Borneolum Syntheticum 0.3-0.7 part, glycerol ethanol water.
3, the compound spirit of treatment acne according to claim 2 is characterized in that being made up of following materials of weight proportions: 1.2 parts in erythromycin, 1.5 parts in chloromycetin, 0.7 part of Oleum menthae, 0.5 part of Borneolum Syntheticum, 100 parts of glycerol ethanol waters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610043867 CN1872085A (en) | 2006-04-25 | 2006-04-25 | Compound tincture for treating acne |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610043867 CN1872085A (en) | 2006-04-25 | 2006-04-25 | Compound tincture for treating acne |
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| CN1872085A true CN1872085A (en) | 2006-12-06 |
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| CN 200610043867 Pending CN1872085A (en) | 2006-04-25 | 2006-04-25 | Compound tincture for treating acne |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030805A (en) * | 2015-07-27 | 2015-11-11 | 张建明 | Acne-eliminating tincture medicine and preparation method thereof |
-
2006
- 2006-04-25 CN CN 200610043867 patent/CN1872085A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030805A (en) * | 2015-07-27 | 2015-11-11 | 张建明 | Acne-eliminating tincture medicine and preparation method thereof |
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| ASS | Succession or assignment of patent right |
Owner name: WANG SHIKE Free format text: FORMER OWNER: ZHANG JUMIN Effective date: 20070511 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20070511 Address after: 273200 Surabaya County People's Hospital of Shandong Province Applicant after: Wang Shike Address before: 273200 Surabaya County People's Hospital of Shandong Province Applicant before: Zhang Jumin |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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