CN1864699A - Novel dosage form of multiple Vitamins - Google Patents
Novel dosage form of multiple Vitamins Download PDFInfo
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- CN1864699A CN1864699A CN 200510040153 CN200510040153A CN1864699A CN 1864699 A CN1864699 A CN 1864699A CN 200510040153 CN200510040153 CN 200510040153 CN 200510040153 A CN200510040153 A CN 200510040153A CN 1864699 A CN1864699 A CN 1864699A
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- Prior art keywords
- vitamin
- capsule
- little shape
- trace element
- coat
- Prior art date
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Links
- 229940088594 vitamin Drugs 0.000 title claims abstract description 47
- 229930003231 vitamin Natural products 0.000 title claims abstract description 47
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 47
- 239000011782 vitamin Substances 0.000 title claims abstract description 47
- 239000002552 dosage form Substances 0.000 title description 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 35
- 239000011573 trace mineral Substances 0.000 claims abstract description 24
- 235000013619 trace mineral Nutrition 0.000 claims abstract description 24
- 239000003086 colorant Substances 0.000 claims abstract description 17
- 239000002775 capsule Substances 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 20
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 10
- 229930003268 Vitamin C Natural products 0.000 claims description 10
- 235000019154 vitamin C Nutrition 0.000 claims description 10
- 239000011718 vitamin C Substances 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 9
- 229930003427 Vitamin E Natural products 0.000 claims description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 9
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 235000019155 vitamin A Nutrition 0.000 claims description 9
- 239000011719 vitamin A Substances 0.000 claims description 9
- 235000019165 vitamin E Nutrition 0.000 claims description 9
- 239000011709 vitamin E Substances 0.000 claims description 9
- 229940046009 vitamin E Drugs 0.000 claims description 9
- 229940045997 vitamin a Drugs 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 8
- 239000007901 soft capsule Substances 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 7
- 229930003451 Vitamin B1 Natural products 0.000 claims description 7
- 229930003471 Vitamin B2 Natural products 0.000 claims description 7
- 229930003316 Vitamin D Natural products 0.000 claims description 7
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 7
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 7
- 229910052802 copper Inorganic materials 0.000 claims description 7
- 239000010949 copper Substances 0.000 claims description 7
- 239000011777 magnesium Substances 0.000 claims description 7
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- 239000011591 potassium Substances 0.000 claims description 7
- 229910052700 potassium Inorganic materials 0.000 claims description 7
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 7
- 229960002477 riboflavin Drugs 0.000 claims description 7
- 229960003495 thiamine Drugs 0.000 claims description 7
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 7
- 235000010374 vitamin B1 Nutrition 0.000 claims description 7
- 239000011691 vitamin B1 Substances 0.000 claims description 7
- 235000019164 vitamin B2 Nutrition 0.000 claims description 7
- 239000011716 vitamin B2 Substances 0.000 claims description 7
- 235000019158 vitamin B6 Nutrition 0.000 claims description 7
- 239000011726 vitamin B6 Substances 0.000 claims description 7
- 235000019166 vitamin D Nutrition 0.000 claims description 7
- 239000011710 vitamin D Substances 0.000 claims description 7
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 7
- 229940011671 vitamin b6 Drugs 0.000 claims description 7
- 229940046008 vitamin d Drugs 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 5
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 5
- 239000000460 chlorine Substances 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 229910052804 chromium Inorganic materials 0.000 claims description 5
- 239000011651 chromium Substances 0.000 claims description 5
- 235000016768 molybdenum Nutrition 0.000 claims description 5
- 239000011669 selenium Substances 0.000 claims description 5
- 229910052711 selenium Inorganic materials 0.000 claims description 5
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 4
- 229930003779 Vitamin B12 Natural products 0.000 claims description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 4
- 229910052750 molybdenum Inorganic materials 0.000 claims description 4
- 239000011733 molybdenum Substances 0.000 claims description 4
- 235000019163 vitamin B12 Nutrition 0.000 claims description 4
- 239000011715 vitamin B12 Substances 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 abstract description 9
- 238000000576 coating method Methods 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 3
- 238000004458 analytical method Methods 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 description 38
- 239000002671 adjuvant Substances 0.000 description 11
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 7
- 235000019700 dicalcium phosphate Nutrition 0.000 description 7
- 229940023488 pill Drugs 0.000 description 7
- 239000008187 granular material Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 5
- 239000007779 soft material Substances 0.000 description 5
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 229960000367 inositol Drugs 0.000 description 4
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 4
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 229910052748 manganese Inorganic materials 0.000 description 3
- 239000011572 manganese Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 101800002326 Adipokinetic hormone Proteins 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 2
- 235000004237 Crocus Nutrition 0.000 description 2
- 241000596148 Crocus Species 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 108010042362 beta-Lipotropin Proteins 0.000 description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 2
- 229960002079 calcium pantothenate Drugs 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010061291 Mineral deficiency Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- -1 compound vitamin Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229950005770 hyprolose Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940089784 niacinamide 20 mg Drugs 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 229940023136 pantothenic acid 10 mg Drugs 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000000112 undernutrition Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to one new form of vitamin preparation with stable vitamin components and easy analysis and determination of the vitamin components. Compatible vitamin and trace element components are first formed into micro tablets with coating of different colors and then encapsulated. The new form of vitamin preparation has improved compliance.
Description
Technical field
The present invention relates to a kind of novel pharmaceutical formulation.
Background technology
Vitamin and mineral are to keep body homergy and healthy requisite important substance, are the important component that constitutes multiple coenzyme and hormone, participate in saccharide, aminoacid, lipid metabolism in the body.When because of disease or undernutrition, can cause vitamin, mineral deficiency, and then cause dysbolismus, cause multiple disease, must give necessary replenishing.The vitamin administration commonly used or the use dosage form of food additive mostly are oral tablet, capsule, granule etc., and patient weak or that be in hospital can also use injection type.
Usually, oral multivitamin often replenishes simultaneously with trace element.The complicated component of its compound preparation is generally made tablet more.Owing to, must use certain stabilizing agent in order to overcome some vitamins stability poor (as vitamin A, vitamin E, vitamin C etc.), cause tablet volume bigger, be inconvenient to swallow.Some vitamin have special odor, also influence particularly child's use of people.Some high-valency metal elements can produce complex reaction with some vitamin (vitamin C etc.), to chemical property, absorption feature generation harmful effect each other.
According to dissolving characteristic, vitamin generally can be divided into water solublity and fat-soluble two big classes, simply with its mixing, be prepared into tablet, when measuring each composition, need extract, separate, be inconvenient to carry out quality controls such as assay, even may interfere with each other mensuration.
The redox characteristic of material is a kind of relative characteristic, vitamin A, vitamin C, vitamin E etc. all have certain redox characteristic, simply with after its mixing, being prepared into single conventional tablet, the stronger vitamin of reproducibility may interact with the stronger vitamin of oxidisability, thereby influences its stability.
The objective of the invention is: a kind of stability of each composition of maintenance and multivitamin novel form that convenient all kinds of component analyses are measured of being beneficial to is provided.
The technical scheme that realizes the object of the invention is as follows:
1, multivitamin novel form comprises not having incompatibility or each other no interactional vitamin, trace element composition behind the compatibility each other, it is characterized in that:
Do not have each other incompatibility or each other behind the compatibility no interactional vitamin, trace element composition be respectively little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
2, according to above-mentioned 1 described multivitamin novel form, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional more than two kinds vitamin, trace element blending constituent be little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
3, according to above-mentioned 1 described multivitamin novel form, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional water soluble vitamins more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional fatsoluble vitamin more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional trace element more than two kinds be little shape tablet with different colours film-coat; And be positioned at capsule.
4, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-20.
5, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-5.
6, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described capsule is the colored transparent capsule, or not colourless transparent capsule.
7, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described little shape tablet also can be drop pill, is little soft capsule.
Useful technique effect of the present invention shows following aspect:
The present invention is by after being prepared into small tablet with mutual influential vitamin, trace element grouping, fill, be packaged in the transparent capsule shells, the assay determination that not only helps improving the stability of each composition and make things convenient for each constituents, each tablet can also be wrapped the film-coat of different colours, to improve the compliance that people use.
The present invention can also be prepared into small tablet with vitamin, the trace element grouping with abnormal flavour and carry out coating to isolate bad smell, small tablet is filled, is packaged in the transparent capsule shells, each tablet can also be wrapped the film-coat of different colours, not only improve the compliance that people use in appearance, can also significantly improve the ubiquitous abnormal flavour shortcoming of general compound vitamin oral formulations.
The present invention also can make some vitamin, the mineral that can make soft capsule or drop pill the small tablet made from other compositions behind small drop pill or the soft capsule and be sub-packed in the transparent capsule jointly.This dosage form is compared the convenience with tangible novelty and assay determination with traditional vitamins dosage form.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Novel form of the present invention is that vitamin, trace element are divided into groups according to the convenience of physicochemical property, interaction characteristic and the pharmaceutical analysis of each composition, after each group compositions added suitable adjuvant, respectively make small tablet after, be surrounded by color or white clothing, be filled in transparent, the coloured or colourless capsule shells.As required, the small tablet at composition place that abnormal flavour is arranged is isolated the abnormal flavour coating, to reach the purpose of shielding abnormal flavour.After relevant composition also can be made small drop pill or soft capsule, be sub-packed in the transparent capsule jointly with the small tablet of other compositions.
Embodiment 1:
According to dissolving characteristic,, be pressed into microplate with the water soluble vitamins mix homogeneously; With fatsoluble vitamin with dissolution with solvents after, absorb mixing, system soft material, 20 mesh sieve system granules, tabletting with adjuvant.Trace element is mixed with adipokinetic hormone, L-lysine, inositol etc., add adjuvant, mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.For regulating the weight of tablet, the calcium hydrogen phosphate in the trace element is distributed in each small tablet.Adjuvant in each small tablet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), regulates each sheet with it and heavily is about 170mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs into white tablets, and the trace element sheet packs into green sheet.Each color chips is filled in the water white capsule shells, promptly successively.
| The sheet color | Orange | White tablets | Green sheet |
| Crude drug | Vitamin B1 2.5mg vitamin B2 2.5mg vitamin B6 250ug cobalamin 0.5ug niacinamide 7.5mg vitamin C 25mg calcium pantothenate 2.5mg | Vitamin A 2500IU vitamin D 200IU vitamin E 5mg | Lipotropin 25mg 1B 12.5mg iron 5mg potassium 5mg copper 500ug manganese 500ug inositol 25mg magnesium 500ug iodine 50ug zinc 250ug |
| Calcium hydrogen phosphate 100mg | Calcium hydrogen phosphate 130mg | Calcium hydrogen phosphate 50mg | |
| Microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20) | Add to 170mg | Add to 170mg | Add to 170mg |
| Magnesium stearate | 3mg | 3mg | 3mg |
| The coating color | Orange | White tablets | Green sheet |
| Capsule shells | Water white transparency | ||
Embodiment 2:
According to dissolving characteristic,, be pressed into microplate with the water soluble vitamins mix homogeneously; With fatsoluble vitamin with dissolution with solvents after, absorb mixing, system soft material, 20 mesh sieve system granules, tabletting with adjuvant and calcium hydrogen phosphate.With other trace element mix homogeneously, add adjuvant, mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.Adjuvant in each sheet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), and regulating each sheet with it heavily is 160mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs the au bleu sheet, and the trace element sheet packs into the cherry red sheet.Each color chips is filled in the water white capsule shells successively, that is, concrete composition sees the following form.
| The sheet color | Orange | Blue sheet | The cherry red sheet |
| Crude drug | Vitamin B1 3mg vitamin B2 3.4mg vitamin B6 3mg cobalamin 9ug niacinamide 20mg vitamin C 90mg pantothenic acid 10mg | Vitamin A 5000IU vitamin D 400IU vitamin E 30IU calcium 40mg phosphorus 31mg | Ferrum 27mg copper 2mg iodine 150ug zinc 15mg magnesium 100mg chromium 15 μ g molybdenums 15 μ g |
| Folic acid 400ug biotin 30ug | Selenium 10 μ g manganese 5mg chlorine 7.5mg potassium 7.5mg | ||
| Microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20) | Add to 160mg | Add to 160mg | 0 |
| Magnesium stearate | 3mg | 3mg | 3mg |
| The coating color | Orange | Blue sheet | Red tab |
| Capsule shells | Light green is transparent | ||
Embodiment 3:
According to dissolving characteristic,, add suitable adjuvant and be pressed into microplate the water soluble vitamins mix homogeneously; Fatsoluble vitamin with after the oiliness adjuvant dissolving, is made drop pill or soft capsule.Compacting is in blocks separately with calcium hydrogen phosphate, and other trace element mix with adipokinetic hormone, L-lysine, inositol etc., add adjuvant, and mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.Adjuvant in each sheet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), and regulating each sheet with it heavily is 150mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs into white tablets, and the trace element sheet packs into green sheet.Each color chips and drop pill or soft capsule are filled in the transparent capsule shells of light crocus successively, that is, concrete composition sees the following form.
| The sheet color | Orange | Drop pill or soft capsule | White tablets | Green sheet |
| Crude drug | Vitamin B1 2.5mg vitamin B2 2.5mg vitamin B6 250ug cobalamin 0.5ug niacinamide 7.5mg vitamin C 25mg calcium pantothenate 2.5mg | Vitamin A 2500IU vitamin D 200IU vitamin E 5mg | Lipotropin 25mg 1B 12.5mg iron 5mg potassium 5mg copper 500ug manganese 500ug inositol 25mg magnesium 500ug iodine 50ug zinc 250ug | Calcium hydrogen phosphate 180mg |
| Microcrystalline Cellulose-low the replacement | Add to 150mg | 0 | Add to 150mg | 0 |
| Hyprolose (100 orders, ratio 80: 20), | ||||
| Magnesium stearate | 3mg | 0 | 3mg | 3mg |
| The coating color | Orange | White tablets | Green sheet | |
| Capsule shells | Light crocus transparent capsule | |||
Claims (7)
1, multivitamin novel form comprises not having incompatibility or each other no interactional vitamin, trace element composition behind the compatibility each other, it is characterized in that:
Do not have each other incompatibility or each other behind the compatibility no interactional vitamin, trace element composition be respectively little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
2, multivitamin novel form according to claim 1, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional more than two kinds vitamin, trace element blending constituent be little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
3, multivitamin novel form according to claim 1 is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional water soluble vitamins more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional fatsoluble vitamin more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional trace element more than two kinds be little shape tablet with different colours film-coat; And be positioned at capsule.
4, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-20.
5, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-5.
6, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described capsule is the colored transparent capsule, or not colourless transparent capsule.
7, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described little shape tablet also can be drop pill, is little soft capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510040153 CN1864699A (en) | 2005-05-20 | 2005-05-20 | Novel dosage form of multiple Vitamins |
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| CN 200510040153 CN1864699A (en) | 2005-05-20 | 2005-05-20 | Novel dosage form of multiple Vitamins |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401809B (en) * | 2008-11-12 | 2011-07-20 | 杭州赛诺菲民生健康药业有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN107712857A (en) * | 2017-10-18 | 2018-02-23 | 北京逯博士行为医学科技研究院有限公司 | A kind of Chinese meal bag and preparation method thereof |
-
2005
- 2005-05-20 CN CN 200510040153 patent/CN1864699A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401809B (en) * | 2008-11-12 | 2011-07-20 | 杭州赛诺菲民生健康药业有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN107712857A (en) * | 2017-10-18 | 2018-02-23 | 北京逯博士行为医学科技研究院有限公司 | A kind of Chinese meal bag and preparation method thereof |
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