CN1832101A - A linear ion trap-time-of-flight mass spectrometry instrument - Google Patents
A linear ion trap-time-of-flight mass spectrometry instrument Download PDFInfo
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- CN1832101A CN1832101A CN 200610025006 CN200610025006A CN1832101A CN 1832101 A CN1832101 A CN 1832101A CN 200610025006 CN200610025006 CN 200610025006 CN 200610025006 A CN200610025006 A CN 200610025006A CN 1832101 A CN1832101 A CN 1832101A
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Abstract
This invention provides a radial introduced vertical serial linear ionic trap-flying time mass spectrography instrument without interface including an ionic source and a transmission part, an axial introduction linear ionic trap and a radial serial flying time mass spectrograph, in which, the original radial outgoing technology of the linear ionic trap is taken as the vertical introduced technology of a flying time analyzer, which keeps the advantages of the linear ionic trap and flying time analyzer.
Description
Technical field
The invention belongs to the mass spectrometer technical field, be specifically related to a kind of multi-stage ms analytical instrument.Particularly, the invention provides a kind of no interface and radially introduce vertical in-line linear ion hydrazine-time-of-flight mass spectrometer.
Background technology
Mass spectrometer is an instrument of measuring the molecule mass-to-charge ratio, can be used as unknown material evaluation, quantitative analysis and molecule, structure is determined, is widely used in aspects such as biology, medicine, environment and geological and mineral.Because of it is accurately effectively used, mass-spectrometric technique various mass spectrometers since being born develop rapidly.Magnetic field analysis device, quadrupole rod filter, ion trap analyzer, ion cyclotron resonance analyzer and Time-of flight analyzer become the representative of mass analyzer, and the coupling of various analyzers is also in continuous trial.
The ion trap analyzer can be realized the plural serial stage mass spectrum, belongs to the time tandem mass spectrometer.Time-of flight analyzer possesses height and the fast ion transmission efficiency and the mass range of broad, can be connected with the pulsed ion beam preferably.Replacing the conventional ion trap with linear ion hydrazine is new approaches and new instrument, but the time of axial ion beam disperses and spatial dispersion becomes an impassable problem.Generally the multiple techniques of ion trap analyzer and Time-of flight analyzer is suggested and realizes, but still has unsatisfactory place in ion transfer and modulation, needs coffret from the ion trap to the Time-of flight analyzer.
Summary of the invention
The purpose of this invention is to provide a kind of linear ion hydrazine-flight time mass spectrometer, improve its sensitivity and accuracy to be applicable to high-precision pointed collar territories such as bioanalysis, identification of proteins.
The invention provides a kind of linear ion hydrazine-flight time mass spectrometer, comprise ion source and hop, linear ion hydrazine and time-of-flight mass spectrometer, this linear ion hydrazine is directly radially connected with Time-of flight analyzer; Have slit on the linear ion hydrazine 6 lower end electrode sheets, the electrode slice that cracks is aimed at the accelerating region 7 of flight time tube.
Of the present inventionly radially draw vertical in-line linear ion hydrazine-flight time mass spectrometer, comprise ion source and hop, linear ion hydrazine and time-of-flight mass spectrometer, its intermediate ion produces and hop, in order to the ionization of sample and the initial option modulation of ion, form by electric spray ion source, sampling spiroid, two-stage radio-frequency quadrupole rod and electron lens, the ion beam that is fit to this instrument is provided; Linear ion hydrazine has slit on the lower end electrode sheet, axially introduces ion beam and carries out ion selection, storage, cracked scanning and pre-acceleration, and ion beam is radially drawn via slit and directly injected Time-of flight analyzer, can do the multi-stage ms analysis; Reflection time-of-flight mass is connected with linear ion hydrazine is vertical, and its flight time is recorded and differentiates behind ion process accelerating region and the echo area.
In the linear ion hydrazine-flight time mass spectrometer of the present invention, be added on the direction of the pulse voltage may command ion beam of linear ion hydrazine 6, make it vertically enter the flight time tube.
Of the present inventionly radially draw vertical tandem linear ion hydrazine-time-of-flight mass spectrometer, linear ion hydrazine (6) is connected with the flying time mass spectrum analysis device is vertical, and a lateral electrode sheet that cracks is aimed at the accelerating region (7) of flight time tube; The sample for preparing by electric spray ion source (1) ionization after, enter first order radiofrequency quadrupole (3) and the preliminary collision selection of second level radiofrequency quadrupole (4) through sampling spiroid (2), be modulated into ion beam through electron lens (5) again with less spatial dispersion and energy dispersion; Linear ion hydrazine (6) carries out the selection and the storage of different phase to ion, and multipole mass spectrum pattern intermediate ion is further cracked, and modulating pulse makes object ion penetrate and carry out pre-acceleration along the lower end slit, has compensated the spatial dispersion of ion beam; The free flight after accelerating region (7) quickens once more of ion beam after the pre-acceleration is located to reflect the back at reflector (8) and is arrived microchannel plate (9), and time-to-digit converter (10) adds up and notes down the ion-conductance signal; The external vacuum pump of interface (11) is with the regulating system pneumatic parameter; The pulse setting that changes linear ion hydrazine can realize multi-stage ms.
In the embodiments of the invention, linear ion hydrazine is axially introduced the ion beam of preliminary modulation and is drawn from 1mm wide slot radially, ion is selected in linear ion hydrazine and is cooled off, treat under radio-frequency voltage, to continue behind the selected parent ion cracked, ion beam draws and injects Time-of flight analyzer under radial electric field, ion beam through ovennodulation is rule and the little flat sheet-like of decentralization, and unified primary power is arranged, and greatly reduces space error and energy error.
In the linear ion hydrazine-flight time mass spectrometer of the present invention, linear ion hydrazine adopts superlinishing stainless steel cylinder (or dull and stereotyped) to make, surface roughness is less than 0.012mm, the circularity trueness error is not more than 0.04mm, the acceleration pole piece of length and flight time tube internal modulation accelerating region is complementary, be about about 80mm (respectively can with reference to the accompanying drawings in 6 and 7) diameter and internal diameter and do not have certain requirement, the thick cylindrical steel plate of 10mm is arrived in employing 5, builds after the process laser cutting is divided into four parts to form.Portion therein is carved with slit vertically.
Among the present invention, the slit width of linear ion hydrazine and time-of-flight mass spectrometer interface is that 1mm is to 2mm.
Of the present invention radially drawing in vertical tandem linear ion hydrazine-time-of-flight mass spectrometer, it is not initiative but to adopt the ion beam of radially drawing from linear ion hydrazine be to have initiated that Time-of flight analyzer further separates the vertical ion beam of introducing to the ion beam of vertical introducing, and whole Time-of flight analyzer satisfies final separation and the record to fragment ion.The design of two acceleration has effectively reduced the accelerating field infiltration.Reflective design is prolonged free time of flight.Double-deck aperture plate all is housed between the electrode of accelerating region and emitter region, obtains two-stage accelerating field and two-stage reflected field more uniformly.Add the individual layer aperture plate before the microchannel plate, detector adds stainless steel substrates, has well shielded the interference signal.This radially draws vertical tandem linear ion hydrazine-flight time mass spectrometer and can carry out the selectivity storage of ion and quicken realization high-resolution high-quality upper limit plural serial stage mass spectrum in advance.Linear ion hydrazine-flight time mass spectrum of the present invention commercially available prod sensitivity at present and accuracy are moreover improved, and are particularly useful for high-precision fields such as bioanalysis, identification of proteins.
Description of drawings
Fig. 1 always schemes for this structure of radially drawing vertical tandem linear ion hydrazine-flying time mass spectrum analysis instrument.
Fig. 2 radially draws the linear ion hydrazine processing schematic diagram of vertical tandem linear ion hydrazine-flying time mass spectrum analysis instrument with Fig. 3 for this.
Fig. 4 radially draws the linear ion hydrazine structure chart of vertical tandem linear ion hydrazine-flying time mass spectrum analysis instrument for this.
Number in the figure: 1 is electric spray ion source, and 2 is sampling spiroid, and 3 is first order radiofrequency quadrupole, and 4 is second level radiofrequency quadrupole, 5 is electron lens, and 6 is linear ion hydrazine, and 7 is accelerating region, and 8 is reflector, 9 is microchannel plate, and 10 is time-to-digit converter, and 11 is the vacuum pump interface.
Embodiment
Below in conjunction with drawings and Examples the present invention is further described:
In the present embodiment, linear ion hydrazine as shown in Figure 2, adopting the superlinishing cylinder is raw material, external diameter 20mm, internal diameter 16mm, long 130mm requires the periphery surface roughness less than 0.012mm, the circularity franchise is no more than 0.04mm with assurance curved surface degree.This cylinder of laser cutting is impartial four parts, builds linear ion hydrazine shown in Fig. 2 (c).General sample concentration should be less than 10
-5M, needle point select 2-3 kilovolt discharge voltage, and the sampling model distance before needle point and the sampling spiroid is generally 1-3cm.Molecular ion behind the electro-spray ionization and fragment enter first radiofrequency quadrupole and tentatively go molten with the collision of background gas in axial oscillatory movement and produce certain fragment ion.Converge at axis after entering second radiofrequency quadrupole, after the electron lens modulation, inject linear ion hydrazine along axis.Ion beam obtains selecting in linear ion hydrazine and storage, and ion selected in multipole mass spectrum pattern is by further cracked.Ion beam after the modulation radially also vertical flight time accelerating region of introducing of pre-acceleration arrives at microchannel plate again after the reflection of echo area.The signal of telecommunication that microchannel plate obtains with pulse digital quantizer input time, is scaled the flight time by discriminator, and accumulated signal is also exported peak shape.Also optional majority level mass spectrum repeats to select ion Cheng Feng.
Claims (4)
1, a kind of linear ion hydrazine-flight time mass spectrometer comprises ion source and hop, linear ion hydrazine and time-of-flight mass spectrometer, it is characterized in that, linear ion hydrazine is directly radially connected with Time-of flight analyzer; Have slit on linear ion hydrazine (6) the lower end electrode sheet, the electrode slice that cracks is aimed at the accelerating region (7) of flight time tube.
2, linear ion hydrazine-flight time mass spectrometer according to claim 1 is characterized in that being added on the direction of the pulse voltage may command ion beam of linear ion hydrazine (6), makes it vertically enter the flight time tube.
3, linear ion hydrazine-flight time mass spectrometer according to claim 1 is characterized in that linear ion hydrazine adopts superlinishing cylinder or plate to make, and the surface roughness of cylinder is 0-0.012mm, and the circularity trueness error is not more than 0.04mm.
4, linear ion hydrazine-flight time mass spectrometer according to claim 1, the slit width that it is characterized in that linear ion hydrazine and time-of-flight mass spectrometer interface are that 1mm is to 2mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610025006 CN1832101A (en) | 2006-03-23 | 2006-03-23 | A linear ion trap-time-of-flight mass spectrometry instrument |
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| CN 200610025006 CN1832101A (en) | 2006-03-23 | 2006-03-23 | A linear ion trap-time-of-flight mass spectrometry instrument |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101158641B (en) * | 2007-11-21 | 2010-06-02 | 中国科学院武汉物理与数学研究所 | Non-collinear mass-resolved threshold ionization spectrometer |
| CN101335177B (en) * | 2007-06-29 | 2010-06-09 | 株式会社日立制作所 | Mass analyzer, ion mobility analyzer |
| CN102157328A (en) * | 2011-03-21 | 2011-08-17 | 复旦大学 | SIMS (Secondary Ion Mass Spectrum) primary ion source with ion selection and storage functions |
| CN107092769A (en) * | 2012-05-18 | 2017-08-25 | Dh科技发展私人贸易有限公司 | For the system and method in Tandem Mass Spectrometry Analysis using staggeredly window width |
| CN107727730A (en) * | 2017-11-29 | 2018-02-23 | 厦门大学 | A kind of dual reflective flight time mass spectrum optoelectronic speed imager |
| CN112204701A (en) * | 2018-05-31 | 2021-01-08 | 英国质谱公司 | Desk type time-of-flight mass spectrometer |
| CN113406182A (en) * | 2021-06-30 | 2021-09-17 | 昆山禾信质谱技术有限公司 | Tandem mass spectrometry device and mass spectrometry detection system |
| CN113725064A (en) * | 2021-08-10 | 2021-11-30 | 复旦大学 | Ion trap-time-of-flight cascade reaction mass spectrum device and operation method thereof |
| US11879470B2 (en) | 2018-05-31 | 2024-01-23 | Micromass Uk Limited | Bench-top time of flight mass spectrometer |
| US12027359B2 (en) | 2018-05-31 | 2024-07-02 | Micromass Uk Limited | Bench-top Time of Flight mass spectrometer |
-
2006
- 2006-03-23 CN CN 200610025006 patent/CN1832101A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101335177B (en) * | 2007-06-29 | 2010-06-09 | 株式会社日立制作所 | Mass analyzer, ion mobility analyzer |
| CN101158641B (en) * | 2007-11-21 | 2010-06-02 | 中国科学院武汉物理与数学研究所 | Non-collinear mass-resolved threshold ionization spectrometer |
| CN102157328A (en) * | 2011-03-21 | 2011-08-17 | 复旦大学 | SIMS (Secondary Ion Mass Spectrum) primary ion source with ion selection and storage functions |
| CN107092769A (en) * | 2012-05-18 | 2017-08-25 | Dh科技发展私人贸易有限公司 | For the system and method in Tandem Mass Spectrometry Analysis using staggeredly window width |
| CN107092769B (en) * | 2012-05-18 | 2020-07-10 | Dh科技发展私人贸易有限公司 | Systems and methods for using staggered window widths in tandem mass spectrometry |
| CN107727730A (en) * | 2017-11-29 | 2018-02-23 | 厦门大学 | A kind of dual reflective flight time mass spectrum optoelectronic speed imager |
| CN112204701A (en) * | 2018-05-31 | 2021-01-08 | 英国质谱公司 | Desk type time-of-flight mass spectrometer |
| US11879470B2 (en) | 2018-05-31 | 2024-01-23 | Micromass Uk Limited | Bench-top time of flight mass spectrometer |
| CN112204701B (en) * | 2018-05-31 | 2024-04-30 | 英国质谱公司 | Bench-top time-of-flight mass spectrometer |
| US12027359B2 (en) | 2018-05-31 | 2024-07-02 | Micromass Uk Limited | Bench-top Time of Flight mass spectrometer |
| CN113406182A (en) * | 2021-06-30 | 2021-09-17 | 昆山禾信质谱技术有限公司 | Tandem mass spectrometry device and mass spectrometry detection system |
| CN113725064A (en) * | 2021-08-10 | 2021-11-30 | 复旦大学 | Ion trap-time-of-flight cascade reaction mass spectrum device and operation method thereof |
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