CN1810257A

CN1810257A - Oral liquid of Huonaosu

Info

Publication number: CN1810257A
Application number: CNA200510071861XA
Authority: CN
Inventors: 钟健琳
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-05-26
Filing date: 2005-05-26
Publication date: 2006-08-02

Abstract

The present invention discloses one kind of functional health food produced with animal brain tissue extracting liquid as main component and L-arginine, trimethyl glycine, tetrahydrofolic acid, citric aci, vitamin B2, vitamin B6, vitamin B12, menthol, etc as supplementary material. The functional health food is used in repairing damaged nerve cell of cerebral tissue as well as in improving memory and delaying senility.

Description

Oral liquid of Huonaosu

One, technical field

The present invention relates to a kind of health functional food prescription and preparation thereof that is used for the repair of the impaired neurocyte of brain tissue impairment and improves the memory slow down aging that a kind of animal brain extract and L-arginine, citric acid, stevioside etc. are made.

Two, background technology

Since nerve growth factor NGF finds, people recognize contains the abundant neural all kinds of factors in the animal brain, from the fresh animal cerebral tissue, extract all kinds of neural factors that have obvious biologic activity with modern biological extraction process, do not add any external reagent.Outer general property gangliosides material is with after neuron membrane combines, can increase every function of nerve growth factor, promote nerve growth, strengthen the nerve synapse projection, strengthen signal conduction between neurocyte, quicken and strengthen the effect of each function of nervous system, can promote to recover dormancy and impaired neurocyte function.

The L-arginine is to be used for substrate with the short nitric oxide that changes into of the action pathway that promotes the nitric oxide invertase, and then promotes vascular endothelial cell to recover elasticity and blood circulation promoting.NO is generated through nitricoxide synthase (NOS) catalysis by the L-arginine.Three kinds of approach of NO:

1. eNOS endothelium-at blood vessel endothelium is that the smooth muscle cell of blood vessel is loosened and blood vessel dilating.

2. nNOS nerve-at nerve synapse is to be used as the nerve conduction factor.

3. bringing out property of iNOS-can damage tumor cell and it is killed at macrophage stops its propagation.

4. NO has following physiological function in nervous system: (1) regulates neurohumoral release; (2) NO that is discharged by cerebrovascular endothelium and cerebrovascular adventitia autonomic nerve regulates the blood flow of brain; (3) activation by NOS in the neuron produces NO, influences the small artery in the brain, thereby regulates big cerebral blood flow.During the cerebrovascular infarction, multiple excitatory amino acid is discharged in the ECS, stimulates N-methyl D-asparagine acid acceptor, and extracellular calcium ion is entered in the neuron, activates NOS, and the NO of neuron generation and release is increased.During focal cerebral ischemia, also produce a large amount of NO in the brain.NO and O2 reaction form NO and cause cerebral lesion.Zoopery shows, if give SOD before the animal brain ischemia, can significantly reduce the Infarction volume of cerebral tissue.But excessive N OS inhibitor also can suppress the NOS activity of cerebrovascular endothelium, and the NO that endotheliocyte is produced reduces, and has hindered cerebral vasodilators, and has reduced the platelet adhesion inhibitory action, increases the weight of brain injury on the contrary.

Three, summary of the invention:

The object of the invention provides a kind of prescription and application thereof of the brain oral liquid of living.Its prescription is as follows:

Animal brain's extracting solution 0.1～2.%

L-arginine 0.1～10mg

Trimethyl glycine 0.1-30g

Vitamin B6 10-40mg

Vitamin B12 0.01-0.2mg

Tetrahydrofolic acid 0.5-2mg

Citric acid is transferred pH4.0-5.5

Menthol is an amount of

Lac regis apis is an amount of

Vitamin E 0-2mg

The present invention is achieved in that

With animal brain (pig, cattle, sheep, horse, monkey etc.) is raw material, after homogenate is smashed to pieces, heat to 95～100 ℃, and insulation 30mins～60mins, ℃ freezing 24hrs boils filtration after thawing again then-20.With the ultrafilter membrane molecular weight that dams is the brain activated protein and the peptide matters of the following molecular weight of 30,000 dalton, obtains brain active substance extracting solution, adds the prescription agent successively by the prescription amount, and fill becomes oral liquid formulations to get final product.

Claims

1, a kind of repair that is used for the impaired neurocyte of brain tissue impairment of making such as a kind of animal brain's extract and L-arginine, trimethyl glycine, vitamin B6, vitamin B12, vitamin E, tetrahydrofolic acid, citric acid, menthol, Lac regis apis and health functional food prescription and the preparation thereof that improves the memory slow down aging.

2, according to 1 of claim the, its prescription is as follows:

Animal brain's extracting solution 0.1～2.%

L-arginine 0.1～10mg

Trimethyl glycine 0.1-30g

Vitamin B6 10-40mg

Vitamin B12 0.01-0.2mg

Tetrahydrofolic acid 0.5-2mg

Citric acid is transferred pH4.0-5.5

Menthol is an amount of

Lac regis apis is an amount of

Vitamin E 0-2mg

3, according to 1 of claim the, selecting the L-arginine for use is to be used for substrate with the short nitric oxide that changes into of the action pathway that promotes the nitric oxide invertase, and then promotes vascular endothelial cell to recover elasticity and blood circulation promoting.NO has following physiological function in nervous system: (1) regulates neurohumoral release; (2) NO that is discharged by cerebrovascular endothelium and cerebrovascular adventitia autonomic nerve regulates the blood flow of brain; (3) activation by NOS in the neuron produces NO, influences the small artery in the brain, thereby regulates big cerebral blood flow.

4, according to 1 of claim the, people's reported first such as Carson and Gerritsen the HHcy case, be a learning difficulty, the child that growth is quickened is contained the homocysteine of high concentration in its blood.Select trimethyl glycine, vitamin B6, vitamin B12, tetrahydrofolic acid prescription, can effectively reduce the homocysteine value of blood middle and high concentration, promote between brain neuroblastoma cell by the leading signal conduction of neurotransmitter.

5, according to 1 of claim the, be raw material with animal brain (pig, cattle, sheep, horse, monkey etc.), after homogenate is smashed to pieces, heat to 95～100 ℃, insulation 30mins～60mins, ℃ freezing 24hrs boils filtration after thawing again then-20.With the ultrafilter membrane molecular weight that dams is the brain activated protein and the peptide matters of the following molecular weight of 30,000 dalton, obtains brain active substance extracting solution, adds the prescription agent successively by the prescription amount, and fill becomes oral liquid formulations to get final product.