CN1794948A - Fluorescence filter for tissue examination and imaging - Google Patents
Fluorescence filter for tissue examination and imaging Download PDFInfo
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- CN1794948A CN1794948A CN 200480014074 CN200480014074A CN1794948A CN 1794948 A CN1794948 A CN 1794948A CN 200480014074 CN200480014074 CN 200480014074 CN 200480014074 A CN200480014074 A CN 200480014074A CN 1794948 A CN1794948 A CN 1794948A
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Abstract
In various embodiments, a tissue inspection system is disclosed that generally includes a handle, a light emitting element (e.g., an LED), a filter, and, in some embodiments, a reflector. In a preferred embodiment, a light emitting element and filter are attached to the distal end of the handle so that fluorescence of body tissue can be directly observed through various configurations of filters. In another embodiment, a reflector is integrated with the filter and light emitting assembly to reflect and filter fluorescent light toward the viewer, but in another embodiment, a shield prevents ambient light from interfering with the tissue examination by injecting additional light into the field of view.
Description
The reference of related application
The application comprises the theme of the U.S. Patent application No. 10/209574 (" inspection " uses) that relates to submission on July 31st, 2002, so this application is introduced into as a reference with its integral body.
Technical field
The application relate generally to be used to the to have a physical examination equipment and the method for (particularly tooth and skin) tissue particularly comprise from this equipment and the method that detect with the different fluorescent emission of health tissues unusually.
Background technology
Proposed to utilize fluorescent emission to come test example such as dental caries, speckle, calculus and such as the various device and the method for other bodily tissue abnormal conditions of cancer.In these equipment, need control like this to be used to shine the quantity of light of the predetermined wavelength range of this tissue, so that the controllable number system of the fluorescence that is brought out ground depend on tissue characteristics.And, for (remitted) fluorescence that contrasts irradiates light best and beam back, need the light of the illumination wavelength scope of this quantity of prevention to reach detector and/or observer.However, though most of proposed all control these aspects with existing equipment, also only partly control these aspects.
For example, U.S. Pat 3711700 relates to a kind of demonstration luminous body (disclosing light) that is used to check dental surface.This demonstration luminous body is designed to use with fluorescent dye, and this fluorescent dye for example is a fluorescein sodium.This demonstration luminous body comprises light source and is positioned at the dichroic reflector of this light source back that this dichroic reflector is reflect blue and remaining light of retroeflection forward.Second dichroic filter is positioned at the front of this light source, and makes the blue light transmission and infra-red radiation is reflected back.Reflecting mirror is towards observer's reflect yellow, and other wavelength of transmission.This equipment does not take any measure to control to enter the oral cavity and the amount of the surround lighting of therefore interfering with fluorescence.
U.S. Pat 4266535 discloses a kind of diagnostic lamp, and it uses to check dental surface with fluorescent dye.This lamp comprises with lens and using so that the incandescent lamp bulb light source of diverging light wire harness to be provided.The blue light filter that utilization has the dichroic filter that adds filters these light, makes that these light are perverse to be mapped on the fluorescent dye.In folding adjustable mirror, can observe resulting fluorescence.This equipment is not controlled the amount of the surround lighting that enters the oral cavity yet, and the fluorescence that is brought out does as a whole the observation together with the exciting light that is reflected, rather than the fluorescence that brings out of observation post only.
U.S. Pat 5957687 discloses another kind of diagnosis unit, filtering light source and reflecting mirror that it is included in the housing to be held.Filtering light concentrates on the blue frequencies scope, and fluorescent dye is fluoresced.This can observe in reflecting mirror then.
U.S. Pat 4290433 discloses a kind of method and apparatus that utilizes cold light (luminescence) to detect the dental caries in people's tooth.Measure the cold light from tooth at two predetermined wavelength places, one of them wavelength produces for the surface that contains dental caries and does not contain the surface of dental caries much at one cold light, and another wavelength generation stronger cold light for the surface that contains dental caries.Generate and two corresponding signals of intensity difference of measuring the wavelength place.Base line measurement is carried out in zone in not moth erosion, then probe is pointed to other zones to determine whether to exist dental caries.
U.S. Pat 4515476 has been described a kind of equipment of difference of the cold light ability that is used to estimate dental surface.Disclosed equipment comprises argon laser, and this argon laser is used to produce the visible light that makes in the luminescent predetermined wavelength range of dental surface.Absorption filter is used to eliminate the interior cold light of predetermined wavelength range of reflection and laser.In this way, can be observed unsound dental surface zone, for example dental caries as the dark space.
U.S. Pat 5894620 discloses a kind of electric toothbrush, and it has the device that is used to locate dental plaque.This electric toothbrush comprises and is used for that exciting radiation is sent to the optical fiber of dental surface and is used to receive the cold light that returns or (many) optical fiber of fluorescence signal.Then the signal that returns is handled, thereby activated optical signal or the earcon that there is speckle in expression.
Protective cover is used in combination with irradiation apparatus, and known most of general protective cover is parasols or sunglasses, is used to prevent that detector (for example photographing unit) or human eye are subjected to intensive sun exposure.In dental field, protective cover uses with the treatment photosystem usually, and for example U.S. Pat 5288231; Protective cover described in 6155823 and 4615679.Each patent in described these patents has all been described a kind of photoprotection cover for the use of treatment light device; wherein this protective cover significantly weakens (in the blue light range) light, thus the protection operator exempt from from treatment light harmful and dispersive directly and the indirect light radiation.Except the shape difference, the something in common of all treatment photoprotection covers is that their protection users' eyes exempt from the treatment harmful light radiation that light rifle produced.These protective covers are not controlled the surround lighting that arrives the repair materials in the dental tissue or the amount of treatment light, and these protective covers are not designed to the fluorescence of observing purpose and being brought out in the transmission dental tissue basically.
According to this background technology, still need can with the bonded protective cover of various detection techniques, thereby the tissue that the excitation light irradiation that only allows the particular range of wavelengths of controlled quantity need be checked, minimizing is exposed to this tissue in the surround lighting, and simultaneously the fluorescence of beaming back from this tissue in inspection is basically towards the observer or be combined in checkout equipment transmission the irradiation apparatus.The present invention solves these needs.
Summary of the invention
Therefore, in one embodiment, the invention provides a kind of protective cover that used handheld tool uses in detecting abnormal structure's situation.This instrument comprises the light source of the light that produces particular range of wavelengths, cause effectively visually detectable from normally with unusual systemic different fluorescent emission.This protective cover allows to be organized in the light that is exposed in the inspection from light source, weakens surround lighting simultaneously.The fluorescence transmission of beaming back from this tissue is by the wall of this protective cover, but stops the light of excitation wavelength, thereby improves normally directly visual with unusual systemic different fluorescence.
In another embodiment, the invention provides a kind of protective cover that photfluoroscope uses in the oral cavity with integrated irradiation apparatus.In this embodiment, this protective cover stops surround lighting, and will guide the tissue that needs inspection into from the light of this irradiation apparatus.The fluorescence of beaming back from this tissue is drawn towards camera sensor.For quantitative purpose, protective cover among this embodiment also plays the effect apart from keeper, so that guarantee that the distance between light source and this tissue is constant on the one hand, guarantee that on the other hand the distance between this tissue and the camera sensor is constant, thereby guarantee the radiant power of the controlled quantity of this tissue of irradiation, and depend on this tissue characteristics corresponding controlled quantity beam back fluorescence.
In some forms of this embodiment, this protective cover is made by deformable material.In other forms, this protective cover is taked the spheric shape of cylinder, cone or part.In certain embodiments, be placed on reflecting mirror on one or more inner surfacies or in one or more inner surface, thereby selectable visual angle is provided in certain embodiments.In other embodiments, at least a portion of this protective cover has amplification characteristic, and is bigger so that observed oral cavity structure looks concerning the observer, and in other embodiments, this reflecting mirror has amplification characteristic.
The invention provides and be used to check to organize whether have unusually, for example check whether dental surface has dental caries maybe may show as improved and alternate instrument, equipment and the method for the bacterium metabolite of speckle.According to the description of this paper, additional embodiments of the present invention and feature and advantage will be conspicuous for the person of ordinary skill of the art.
Description of drawings
Fig. 1 is the perspective view according to the instrument of first embodiment of the invention.
Fig. 2 is the side view that is used for the instrument of checking tooth according to first embodiment of the invention.
Fig. 3 is the perspective view according to the instrument of second embodiment of the invention.
Fig. 4 is the side view that is used for the instrument of checking tooth according to second embodiment of the invention.
Fig. 5 is the perspective view according to the instrument of third embodiment of the invention.
Fig. 6 is the side view that is used for the instrument of checking tooth according to third embodiment of the invention.
Fig. 7 is the side view that is used for the instrument of checking tooth according to fourth embodiment of the invention.
Fig. 8 is the perspective view that is used for the instrument of checking tooth according to fifth embodiment of the invention.
Fig. 9 is the side view of fifth embodiment of the invention.
Figure 10 is the side view according to the instrument of sixth embodiment of the invention, and according to the zoomed-in view of the layering optics of sixth embodiment of the invention.
Figure 11 is the side view according to the layering optics of seventh embodiment of the invention.
Figure 12 is the side view according to the layering optics of eighth embodiment of the invention.
Figure 13 is the side view according to the dermatological applications of ninth embodiment of the invention.
Figure 14 is the sectional view according to the cover/filter of tenth embodiment of the invention.
Figure 15 is the perspective view according to the cover/filter of eleventh embodiment of the invention.
The specific embodiment
In order to promote understanding,, and will utilize special language to describe the present invention referring now to the embodiment shown in the accompanying drawing to the principle of the invention.But, should be appreciated that these descriptions and not meaning that limit the scope of the invention; Since the technical staff in field involved in the present invention generally can expect any change of the embodiment that institute describes or illustrates and further revise and as any other application of the illustrated principle of the invention herein, so can consider above-mentioned these changes, modification and application.
The instrument of tissue the present invention relates generally to be used to have a physical examination, relate in particular to and utilize filtration device structure to carry out the tool and method of tissue examination, the light that this filtration device structure can prevent LED effectively and be sent is directly visual, and the view more clearly of this tissue is provided.Because those feature classes described in features more of the present invention and the inspection application (Inspection application) seemingly, therefore the detailed description of some common components of omission from these explanations still is hereby incorporated by.
Be noted that in presents " filter " means that the light that only allows selected wavelength is by object or layer.
Fig. 1 and 2 illustrates first embodiment of the invention, is dental tool.In Fig. 1, dental tool 10 comprises handle portion 11 and the tip portion 12 that is connected with this handle portion 11 at a certain angle.Light emitting diode (LED) 13 is fixed to the tip of part 12, and filtration device structure 14 is connected on the tip portion 12, contiguous LED 13 and around LED 13.LED 13 preferably sends the light of peak strength between about 380nm and 500nm, more preferably sends the light of peak strength between 390nm and 450nm.
When using this instrument, at least a portion of tip portion 12 is inserted in the mouth, the opening of filtration device structure 14 directly contacts with dental surface as shown in Figure 2 simultaneously.Instrument 10 will be from the light emission of LED 13 to this dental surface, and observes the autofluorescence that this dental surface produces by filtration device structure 14.Because the opening of filtration device structure 14 directly contacts dental surface, and can not leak into the outside of filtration device structure 14, therefore prevent directly visual from the light of LED 13 effectively from the light of LED 13.
Second embodiment has been shown in Fig. 3 and 4.Dental tool 20 among the figure comprises filtration device structure 22, and it is tapered, and is connected to the most advanced and sophisticated and contiguous LED 13 of part 12.Filtration device structure 22 has the narrow opening end that is fastened on the tip portion 12 and towards the wide opening of dental surface.Can use this dental tool 20 in the mode identical, and this dental tool 20 has the wideer advantage of tooth that the dental surface that covered by filtration device structure 22 (as shown in Figure 4) can be covered than first embodiment (as shown in Figure 2) with dental tool 10 (referring to Fig. 1).
Fig. 5 and 6 illustrates the 3rd embodiment.In Fig. 5, dental tool 30 comprises the filtration device structure 32 that has the part spheroid form usually.With identical in a second embodiment mode this filtration device structure 32 being set, and this filtration device structure 32 has the tooth covering power similar to second embodiment.In addition, filtration device structure 32 also provides enlarging function except its filter operation, so that produce the zoomed-in view of this dental surface.
Fig. 7 illustrates the 4th embodiment, and wherein dental tool 40 has part taper and the hemispheric filtration device structure 42 of part.In the inner surface of this filtration device structure 42, be provided with the partly reflecting mirror 43 of the inner surface of precoat filter structure 42.In some forms of the 4th embodiment, a part of filtration device structure 42 that does not have reflecting mirror 43 has amplification characteristic.In some other forms, reflecting mirror 43 scribbles antifog processing (as known to persons skilled in the art), to reduce liquid condensing and build up on mirror surface.According to the 4th embodiment, dental tool 40 will be from the light emission of LED 13 to dental surface, reflected fluorescent light and observe these fluorescence by filtration device structure 42 in reflecting mirror 43.
Fig. 8 and 9 illustrates the 5th embodiment.As shown in Figure 8, the dental tool 50 LED/ filtration device structure assembly 52 that comprises handle portion 11 and be arranged on the end of handle portion 11 at a predetermined angle.This LED/ filtration device structure assembly 52 comprises ring 53, one or more LED 13 and filter 55.LED 13 is arranged on a ring side of 53 so that the illumination of teeth surface, and this filter is arranged on the inside of ring 53.In order to use dental tool 50, as shown in Figure 9, with ring 53 remain on open mouthful near, or be inserted in the mouth and be positioned near the dental surface, so that LED 13 is towards this dental surface.The light that LED 13 is sent is penetrated on tooth, observes the fluorescence that is produced by this tooth by filter 55.In dental tool 50, filter 55 can be constituted and have amplification characteristic, so that the zoomed-in view of this tooth is provided in the process of this instrument of use.
Sixth embodiment of the invention shown in Figure 10 is at flexible program shown in Figure 11 and 12.In Figure 10, light-emitting component 13 is installed in the end of handle 11 together with supporting structure 51 (for example nonflexible line) and optical element 52.Optical element 52 comprises a layer 53-56, and its middle level 53 and 55 is anti-reflecting layers, and layer 54 is light filters, and layer 56 is mirror coatings.Incide the exemplary light on the element 52 shown in Figure 10, be labeled as I.The fluorescence response of the light that to be bodily tissues sent element 13 of at least some the incident illumination I among this embodiment.When incident illumination I passes filter course 54, this incident illumination is filtered, so as to make desired wavelength by and absorb other wavelength.When incident ray I arrived mirror coating 56, this incident ray was reflected and becomes and is reflection ray R.Reflection ray R passes filter course 54 once more so that further weaken the wavelength of not expecting, and propagates the outside of getting back to optical element 52, preferably propagates into observer's eyes.Anti-reflecting layer 53 and 55 reduces decay to observed light R because of the internal reflection in the optical element 52.
Figure 11 represent alternate optical element 52 ', it comprise with Figure 10 in the similar layer 53-56 of those layers.But optical element 52 ' in, light-emitting component 13 is positioned at the back in reflecting layer 56, hole 57 (pass among layer 53-56 each layer) allow light-emitting component 13 through optical elements 52 ' remainder and arrive the organization object that will check.This tissue self fluoresce (as known in the art and like that above-mentioned) and as incident illumination I be mapped to optical element 52 ' on, and as reflected light R reflection, as about illustrated in fig. 10.Hole 57 is columniform holes, perpendicular to the surface of layer 53, the central authorities on this surface by optical element 52 ' all layers.In alternate embodiment, hole 57 has other shapes, and be placed other positions and with other angles be placed on optical element 52 ' in, as those skilled in the art will expect.Be used for the line that energy is passed to light-emitting component 13 pass across optical element 52 ' the conduit 58 at back.
Another alternate embodiment comprises optical element 52 as shown in Figure 12 ".In this embodiment, except layer 53-56 (about what Figure 10 discussed), line 59 is at optical element 52 " periphery (perimeter) near extend so that light-emitting component 13 is connected with power supply by support unit 51.
In Figure 11～12, the energy that is used for irradiation luminous element 13 passes through support unit 51, thereby light-emitting component 13 is connected with power supply, and this power supply for example is the battery case in the handle 11.In alternate embodiment, obtaining electric power by transformator or commutator or under from AC power supplies, as institute in those alternate embodiments is essential or preferred not by the situation of transformator or commutator.
Those skilled in the art will observe, and these reflecting mirror/combination of filters provide the remarkable advantage that is better than golden reflecting mirror and isolating filter.About the former, although the reflection in the golden reflecting mirror may have the red composition of increase, it can not help to observe green composition, and this makes diagnosis more difficult.In addition, concerning the user, the integrated reflecting mirror/light filter of Figure 10～12 is compared with isolating filter with the standard reflection mirror and is easier to operation.
Figure 13 illustrates and applies the present invention to dermatological.In the 9th embodiment, support 60 supporting magnifieres 62, this magnifier is included in the LED ring of the skin that is used for irradiation object 64 of a side.Filter/magnifier 66 is full of outer shroud 62 so that a window to be provided, and doctor or technical staff observe skin lesion to the reaction from the incident illumination of LED by this window.Support arm 68 can move with respect to support 60, so that the observer is according to checking the necessary of infringement or needing and moving magnifier 62.
In the alternative form of this embodiment, support 60 for good and all or be detachably connected on examining table, wall or the luminaire.Support arm 68 all is tensile in the various forms of this embodiment.Although the present invention is described according to inspection to the people, and the present invention's advantageous particularly when being applied to this purpose, the present invention also is applied to other animal or plant tissues, as those skilled in the relevant art will expect.
Be noted that especially application more of the present invention will be in dermatological field.For example, cancer detects (oral cancer and skin carcinoma) and acne/blackhead treatment and can utilize the present invention described herein and that require.
It is also noted that the geometric description of protective cover herein relates generally to the inner surface of protective cover, but the profile of outer surface is described and is shaped for the aesthetic property of the relevant amplification of this instruction and may also is useful using.Be noted that in addition, the traditional mathematics of " cylinder " definition mainly refers in this article: " a: by be parallel to that fixing straight line moves and with the surface of the straight line institute spike (trace) of fixed plane closure curve intersection, b: by the space that cylinder limited and parallel plane and its all elements all intersect ".
It will be apparent to one skilled in the art that top feature can be bonded to each other and/or with check use in disclosed these features combine.Those skilled in the art also can implement the light-emitting component except LED in each embodiment of the present invention.
Turn to Figure 14, this illustrates tenth embodiment of the invention.This embodiment relates to protective cover, reflecting mirror and filter for installation, and this filter for installation is suitable for checking tooth structure and with the controlled seizure image that is provided with very much.In this embodiment, portion of the handle 61 is normally columniform, and with 63 endings of narrower end.Light source 65 and photographing unit hole 67 are arranged in the distal face of end 63.The former sends the light of one or more wavelength by light source 65, and the latter (hole 67) receives the light as picture catching.Hole 67 can comprise lens, one or more CCD and be used for the miscellaneous part of picture catching, as those of ordinary skill in the art will expect.Light source 65 can comprise one or more light emitting diodes etc. equally, as those of ordinary skill in the art will expect.
The light that light source 65 is sent passes cover 69, and this cover also has and is generally columniform shape, and still being tapered in a preferred embodiment becomes narrower far-end.Light from light source 65 is reflected by plane mirror 71, and passes observation panel 73.The autofluorescence of this photo-induced dental tissue returns by observation panel 73, by reflecting mirror 71 reflections, and passes through light filter 75 before being captured as image by hole 67.
Can observe in the preferred embodiment, the length of cover 69 and the configuration of reflecting mirror 71, observation panel 73 and filter allow the DENSP as one man to locate this equipment, so that obtain as one man proportional in time and localized image.For example, the professional can directly be placed on observation panel 73 on the dental surface, places the distance guarantee to keep specific in image capture process (from the object of the bottom surface of observation panel 73 to reflecting mirror 71, to the hole 67, this distance is fixed distance) like this.Utilize the equipment described in the U.S. Pat 6597934 and technology can obtain even location more accurately.In these typical structures, the main body of cover 69 is made of opaque material, for example plastics, and stops all surround lightings to enter picture catchings inner and interference 67 places in the hole basically.In some picture catching situations, patient can close its lip around cover 69, and stops all light to influence picture catching by any way basically.
In other embodiments, cover 69 is disposable, after a patient uses it is abandoned.In other embodiments, transparent plastic cover is placed on the more permanent cover 69, after using this transparent plastic cover is abandoned.In other embodiments, cover 69 more for good and all is fixed on the portion of the handle (hand piece) 61, and in further embodiments, utilize one or more bindiny mechanisms known to the skilled in the mechanical field that cover 69 is snapped in the position of end of portion of the handle 61.
In other embodiments, omit light filter 75, and the image of catching by hole 67 is carried out numerical analysis, to remove the frequency component that is lower than a certain threshold value (for example 520nm or 580nm).Can carry out graphical analysis as mentioned above.
Figure 15 illustrates the far-end of hand-held luminous body and camera apparatus 80, comprises that narrow neck portion (neck portion) 81, white light LEDs 83, blue-ray LED 85, photographing unit hole 87 and opaque distance keep protective cover 89.Three-way switch 91 on the narrow neck portion 81 has three positions, and wherein (1) all LED disconnect, and (2) blue-ray LED is connected, and the inside of gold-tinted filter coverage hole 87, and the connection of (3) white light LEDs, and the inside of grey light-filter coverage hole 87.Like this, the professional can utilize white light and photographing unit to check patient, then, does not even use the instrument of removing from disease population just can obtain the fluoroscopic image of patient (a plurality of) oral cavity structure, thereby diagnoses the situation of tooth or other oral cavity structures.
Although in the description of accompanying drawing and front, at length illustrated and described the present invention; but the present invention should suitably be considered to illustrative; and it is nonrestrictive; should be appreciated that; only illustrate and described preferred embodiment, those skilled in the relevant art can expect to change and revise all be claimed.In addition, all patents, open text, formerly be introduced into as a reference with its integral body at this with application simultaneously and the alternative document of quoting as proof herein, as above-mentioned each all be introduced into as a reference and all sidedly individually and set forth.
Claims (61)
1. instrument that is used to detect one or more abnormal structures situation comprises:
One or more light-emitting components are suitable for and will bring out the light emission of autofluorescence to tissue; And
The protective cover that contiguous these one or more light-emitting components are provided with, wherein this protective cover carries out optical filtering to the light that autofluorescence produced by this tissue.
2. according to the instrument of claim 1, wherein this protective cover has cylinder body shape.
3. according to the instrument of claim 2, wherein this protective cover has the straight cylinder shape.
4. according to the instrument of claim 3, wherein this protective cover has the right circular cylinder shape.
5. according to the instrument of claim 2, wherein this protective cover has cylindrical shape.
6. according to the instrument of claim 1, wherein this protective cover has cone shape.
7. according to the instrument of claim 1, wherein this protective cover has spheroid form.
8. according to the instrument of claim 1, wherein as from the outside of this protective cover observe, at least a portion of this protective cover is amplified the area of space within this protective cover.
9. according to the instrument of claim 1, wherein reflecting mirror is positioned at this protective cover, and is set for reflection at least a portion by the light that autofluorescence sent of oral cavity structure.
10. according to the instrument of claim 1, wherein this protective cover filters the visible light of preset frequency, and this visible light is that the autofluorescence by this oral cavity structure is produced.
11. according to the instrument of claim 1, wherein the quantity of these one or more light-emitting components is four at least, and is provided with loop configuration.
12. according to the instrument of claim 11, wherein the quantity of these one or more light-emitting components is six at least.
13. according to the instrument of claim 11, wherein this protective cover is arranged in the plane that is limited by this ring.
14. according to the instrument of claim 13, wherein this protective cover is full of the plane that is limited by this ring basically.
15. according to the instrument of claim 13, wherein this protective cover comprises amplifying lens.
16. according to the instrument of claim 1, wherein these one or more light-emitting components are light emitting diodes.
17., wherein this protective cover is handled to reduce mist formation according to the instrument of claim 1.
18. according to the instrument of claim 1, wherein the people observes directly the light that passes this protective cover.
19., wherein catch the light that passes this protective cover by the picture catching element according to the instrument of claim 1.
20. according to the instrument of claim 19, wherein this protective cover remains on the picture catching element from this object preset distance place.
21. according to the instrument of claim 1, wherein this tissue is a dental tissue.
22. according to the instrument of claim 1, wherein this tissue is a skin histology.
23. according to the instrument of claim 1, wherein these one or more light-emitting components and protective cover are fixed on the hand-held housing.
24. according to the instrument of claim 1, wherein these one or more light-emitting components and this protective cover by mechanical support in the optional position of user.
25. according to the instrument of claim 1, wherein this tissue is people's a tissue.
26. according to the instrument of claim 1, wherein this tissue is the tissue of dog.
27. according to the instrument of claim 1, wherein this tissue is the tissue of cat.
28. the instrument according to claim 1 further comprises:
Additional one or more light-emitting component is suitable for white light emission to this tissue; And
Switch is optionally enabled
The described one or more light-emitting components that are suitable for launching the light that brings out autofluorescence; Perhaps
The described additional one or more light-emitting components that are suitable for launching white light.
29. an instrument that is used to detect one or more abnormal structures situation comprises:
One or more light-emitting components are suitable for and will bring out the light emission of fluorescence to bodily tissue; And
The protective cover that contiguous these one or more light-emitting components are provided with, wherein at the surround lighting wavelength that brings out the autofluorescence of this tissue at one or more interested wavelength place, this protective cover makes surround lighting arrive this structural incident decay.
30. according to the instrument of claim 29, wherein the wavelength place of the radiation of light-emitting component between about 380nm and about 500nm has peak strength.
31. according to the instrument of claim 30, wherein the wavelength place of the radiation of light-emitting component between about 390nm and about 450nm has peak strength.
32. according to the instrument of claim 29, wherein:
These one or more light-emitting components are incorporated in the handheld unit; And
This protective cover is detachably connected on this handheld unit.
33. according to the instrument of claim 29, wherein the people observes directly the light that passes this protective cover.
34., wherein catch the light that passes this protective cover by the picture catching element according to the instrument of claim 29.
35. according to the instrument of claim 34, wherein this protective cover remains on this picture catching element from this tissue preset distance place.
36. according to the instrument of claim 29, wherein this protective cover does not make the surround lighting wavelength that does not bring out the autofluorescence of this tissue at one or more interested wavelength place significantly decay.
37. according to the instrument of claim 29, wherein this tissue is a dental tissue.
38. according to the instrument of claim 29, wherein:
This tissue is the dental tissue in the oral cavity; And
This protective cover allows enough light effusion oral cavities, thereby allows this oral cavity of visualization when these one or more light-emitting components shine this oral cavity.
39. according to the instrument of claim 29, wherein this tissue is a skin histology.
40. according to the instrument of claim 29, wherein these one or more light-emitting components and protective cover are fixed on the hand-held housing.
41. according to the instrument of claim 29, wherein these one or more light-emitting components and protective cover by mechanical support in the optional position of user.
42. according to the instrument of claim 29, wherein this tissue is people's a tissue.
43. according to the instrument of claim 29, wherein this tissue is the tissue of dog.
44. according to the instrument of claim 29, wherein this tissue is the tissue of cat.
45. the instrument according to claim 29 further comprises:
Additional one or more light-emitting component is suitable for white light emission to this tissue; And
Switch is optionally enabled
The described one or more light-emitting components that are suitable for launching the light that brings out autofluorescence; Perhaps
The described additional one or more light-emitting components that are suitable for launching white light.
46. a system comprises:
Be used to have a physical examination and organize the irradiation apparatus that whether has tissue abnormalities; And
Reflecting mirror with filter layer;
Wherein this reflecting mirror reflects the fluorescence of beaming back from this tissue towards detector basically; And
Wherein this filter layer is significantly decayed the light of the wavelength that brings out this histofluorescence.
47. according to the system of claim 46, wherein this reflecting mirror will amplify from the fluorescence that this tissue is beamed back.
48. according to the system of claim 46, wherein this reflecting mirror has ARC.
49. according to the system of claim 48, wherein this reflecting mirror comprises:
First ARC,
Second ARC,
Light filter layer between first and second ARCs, and
Mirror coating, wherein this second ARC is between this light filter layer and this mirror coating.
50. according to the system of claim 46, wherein this detector is a human eye.
51. according to the system of claim 46, wherein this detector is a photographing unit.
52. according to the instrument of claim 46, wherein this tissue is a dental tissue.
53. according to the instrument of claim 46, wherein this tissue is a skin histology.
54., wherein this protective cover is handled to reduce mist formation according to the instrument of claim 46.
55. according to the instrument of claim 46, wherein
This irradiation apparatus comprises a plurality of light-emitting components of arranging ring formation; And
This reflecting mirror is arranged in this ring.
56. according to the instrument of claim 46, wherein this irradiation apparatus comprises at least one light-emitting component, this at least one light-emitting component is launched peak strength at approximately 380nm and the approximately light between the 500nm.
57. according to the instrument of claim 56, wherein this at least one light-emitting component is launched peak strength at approximately 390nm and the approximately light between the 450nm.
58. according to the instrument of claim 46, wherein filter layer makes wavelength significantly decay less than the light of about 520nm.
59. according to the instrument of claim 58, wherein this filter layer makes wavelength significantly decay less than the light of about 580nm.
60. according to the instrument of claim 46, wherein this reflecting mirror is integrated in the single housing with this irradiation apparatus.
61. according to the instrument of claim 46, wherein this reflecting mirror can disassemble from this irradiation apparatus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47248603P | 2003-05-22 | 2003-05-22 | |
| US60/472,486 | 2003-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1794948A true CN1794948A (en) | 2006-06-28 |
Family
ID=36273256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200480014074 Pending CN1794948A (en) | 2003-05-22 | 2004-05-22 | Fluorescence filter for tissue examination and imaging |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2006528045A (en) |
| CN (1) | CN1794948A (en) |
| BR (1) | BRPI0409493A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102069069A (en) * | 2010-09-27 | 2011-05-25 | 安徽捷迅光电技术有限公司 | Lamp shade for color sorter |
| CN103654730A (en) * | 2013-12-19 | 2014-03-26 | 北京大学 | Fluorescent molecular imaging system based on LED light source and imaging method thereof |
| CN103930017A (en) * | 2011-10-13 | 2014-07-16 | 皇家飞利浦有限公司 | Medical probe with multi-fiber lumen |
| CN110325109A (en) * | 2017-01-09 | 2019-10-11 | 卡尔西维斯有限公司 | Detection device |
| CN111820853A (en) * | 2019-04-21 | 2020-10-27 | 万元芝 | Oral imaging device and method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2692375B1 (en) * | 2011-03-31 | 2018-05-30 | Nemoto Kyorindo Co., Ltd. | Leakage detection sensor and drug infusion system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737104A (en) * | 1985-04-15 | 1988-04-12 | Croll Theodore P | Method of eye protection using hand-held light filter |
| US4615679A (en) * | 1985-06-03 | 1986-10-07 | Wyatt Thomas K | Light shield for use with light curing apparatus |
| GB9810471D0 (en) * | 1998-05-16 | 1998-07-15 | Helmet Hund Gmbh | Toothbrush |
| US6547394B2 (en) * | 1998-10-20 | 2003-04-15 | Victor J. Doherty | Hand-held ophthalmic illuminator |
-
2004
- 2004-05-22 CN CN 200480014074 patent/CN1794948A/en active Pending
- 2004-05-22 JP JP2006530673A patent/JP2006528045A/en active Pending
- 2004-05-22 BR BRPI0409493-0A patent/BRPI0409493A/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102069069A (en) * | 2010-09-27 | 2011-05-25 | 安徽捷迅光电技术有限公司 | Lamp shade for color sorter |
| CN103930017A (en) * | 2011-10-13 | 2014-07-16 | 皇家飞利浦有限公司 | Medical probe with multi-fiber lumen |
| CN103930017B (en) * | 2011-10-13 | 2017-03-08 | 皇家飞利浦有限公司 | There is the medical probe of multifilament inner chamber |
| US10342416B2 (en) | 2011-10-13 | 2019-07-09 | Koninklijke Philips N.V. | Medical probe with multi-fiber lumen |
| CN103654730A (en) * | 2013-12-19 | 2014-03-26 | 北京大学 | Fluorescent molecular imaging system based on LED light source and imaging method thereof |
| CN110325109A (en) * | 2017-01-09 | 2019-10-11 | 卡尔西维斯有限公司 | Detection device |
| CN111820853A (en) * | 2019-04-21 | 2020-10-27 | 万元芝 | Oral imaging device and method |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0409493A (en) | 2006-05-02 |
| JP2006528045A (en) | 2006-12-14 |
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