CN1775317A - Two-chamber prefilled syringe and its prefilling method - Google Patents
Two-chamber prefilled syringe and its prefilling method Download PDFInfo
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- CN1775317A CN1775317A CN 200510032462 CN200510032462A CN1775317A CN 1775317 A CN1775317 A CN 1775317A CN 200510032462 CN200510032462 CN 200510032462 CN 200510032462 A CN200510032462 A CN 200510032462A CN 1775317 A CN1775317 A CN 1775317A
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- piston
- chamber
- cylindrical shell
- rod
- injection tube
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 229940071643 prefilled syringe Drugs 0.000 title claims description 16
- 238000002347 injection Methods 0.000 claims abstract description 81
- 239000007924 injection Substances 0.000 claims abstract description 81
- 239000003814 drug Substances 0.000 claims abstract description 33
- 239000000243 solution Substances 0.000 claims abstract description 18
- 238000007789 sealing Methods 0.000 claims description 56
- 239000007788 liquid Substances 0.000 claims description 31
- 239000004033 plastic Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000003860 storage Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a double-chamber precharged injector and its precharging method. It includes an injection tube formed from upper section of tube body whose tube diameter is larger and lower section of tube body whose tube diameter is smaller, one end of the injection tube is connected with connecting head, an other end is opened. In the injection tube are set an upper piston and a lower piston which are respectively placed in the upper section and lower section of tube body and seal-combined with correspondent inner wall of said tube body. The interior of injector tube body can be divided into a lower cavity chamber and an upper cavity chamber by means of two pistons, the injection medicine and diluent solution are respectively held in the above-mentioned two closed cavity chambers. Besides, said invention also provides its concrete operation method and steps.
Description
Technical field
The invention belongs to the medical packaging field, be specifically related to a kind of pre-charge injector.
Background technology
At present, the syringe that each medical institutions generally uses is the syringe of injecting immediately behind the pumping liquid, and some pre-charge injectors by pharmaceutical factory's prepackage medicinal liquid are also arranged.Pre-charge injector on the market is a single chamber, and only adorns a kind of syringe of liquid medicine, is generally used for being worth higher medicine.Because physics, the chemical characteristic difference of medicine, a lot of medicines could prolong the shelf life with the drying regime package storage.Therefore in hospital's injection process, must extract the required dilute solution of this class medicine with syringe earlier, inject the container that the drying regime medicine is housed, the mixed liquid medicine injection that shakes up into, the same syringe of reuse extracts this medicinal liquid and injects in the human body.
The using method of above-mentioned syringe at present commonly used, complicated operation is loaded down with trivial details on the one hand, is easy to generate pollution in the preparation injection process; Medicine and dilute solution are packed with different vessels respectively on the other hand, produce, use cost is higher.
Summary of the invention
Technical problem to be solved by this invention is the defective that overcomes above-mentioned prior art, providing a kind of can be stored in injection medicine (dry shape medicine or liquid medicine) and dilute solution in the same syringe simultaneously, two kinds of medicines are divided in two confined chambers during storage, can mix easily during use, realization is made up a prescription and is injected disposable finishing, easy and simple to handle, can avoid preparing the pollution that produces in the injection process, two-chamber prefilled syringe that use cost is low and method for pre-charging thereof.
For solving the problems of the technologies described above, the present invention adopts following technical proposals.
A kind of two-chamber prefilled syringe, it is characterized in that it comprises the injection tube of being made up of bigger cylindrical shell epimere of barrel dliameter and the less simplified hypomere of barrel dliameter, the bottom that injection tube is positioned at cylindrical shell hypomere one end is provided with union joint, the center of union joint is provided with the liquid outlet that communicates with the injection tube inner chamber, this liquid outlet is sealed by removable sealing member, and the top that injection tube is positioned at cylindrical shell epimere one end is an opening; Be provided with upper piston and lower piston in the injection tube, lower piston places the cylindrical shell hypomere, and combine with the inner wall sealing of cylindrical shell hypomere, be separated out airtight lower chamber in injection tube, upper piston places the cylindrical shell epimere, and combines with the inner wall sealing of cylindrical shell epimere, in injection tube, be separated out airtight upper chamber, connected by piston brace rod between upper piston and the lower piston, the end that upper piston is relative with the injection tube opening is connected with a upper piston rod, and described upper piston rod extends to outside the injection tube opening.
As a further improvement on the present invention, the end that described lower piston links to each other with piston brace rod offers screw, the two ends of upper piston all offer screw, and the two ends of described piston brace rod are provided with external screw thread, and piston brace rod is connected with lower piston with upper piston by screw thread; Described upper piston rod one end is provided with external screw thread, with upper piston by being threaded, the other end is provided with handle.
The body of rod of described piston brace rod is provided with groove.
The removable sealing member of described sealing liquid outlet can be an easy broken rod that is fractureed easily, and the described easy broken rod that is fractureed easily links to each other with union joint.
The removable sealing member of described sealing liquid outlet can be a sealing cap, and described sealing cap is sheathed on the union joint.
The removable sealing member of described sealing liquid outlet can be a syringe needle sealing shroud, is connected with injection needle on the described union joint, and the syringe needle sealing shroud is sheathed on the injection needle.
Described union joint is a cone.
Described piston brace rod and upper piston rod adopt medical plastic to make, and upper and lower piston adopts medical grade rubber to make.
The method of the above-mentioned two-chamber prefilled syringe of preliminary filling is:
1) it is big and the hypomere barrel dliameter is less and there is the injection tube of a union joint its bottom to make the epimere barrel dliameter, and set liquid outlet in the union joint is sealed by removable sealing member;
2) injection medicine is poured into the less cylindrical shell hypomere of barrel dliameter, can be pressed into the cylindrical shell hypomere with the bonded lower piston of cylindrical shell hypomere inner wall sealing, form the airtight lower chamber that has poured into injection medicine, aerofluxus in the time of tamponade makes lower chamber be in normal pressure and sealing;
3) piston brace rod is screwed in lower piston, dilute solution is poured in the space between piston brace rod and the injection tube, upper piston is pressed into syringe cylinder, and be close to piston brace rod, form and poured into the airtight upper chamber of dilute solution, aerofluxus in the time of tamponade makes upper chamber be in normal pressure and sealing;
4) with upper piston rod and upper piston by being threaded, and continue rotation, also by being threaded, promptly make two-chamber prefilled syringe until upper piston and piston brace rod.
Beneficial effect of the present invention is: two-chamber prefilled syringe of the present invention adopts has the injection tube that two sections different cylindrical shells of barrel dliameter are formed, and in injection tube, be provided with barrel dliameter supporting on, following two pistons, in the syringe cylinder inner chamber, be separated out airtight on, following two chambers, storage at as prepackage injection medicine and dilute solution, can simultaneously injection medicine (dry shape medicine or liquid medicine) and dilute solution be stored in two airtight chambers of same syringe, use the above two to separate fully, can mix easily during use, realization is made up a prescription and is injected disposable finishing, easy and simple to handle, avoided preparing the pollution that produces in the injection process, and simple in structure, the production use cost is low.
Description of drawings
Fig. 1 is the structural representation cutaway view of the embodiment of the invention;
Fig. 2 is the cutaway view of embodiment of the invention injection tube;
Fig. 3 is the cutaway view of lower piston;
Fig. 4 is the front view of piston brace rod;
Fig. 5 is the vertical view cutaway drawing of piston brace rod;
Fig. 6 is the cutaway view of upper piston;
Fig. 7 is the front view of upper piston rod;
Fig. 8 is the vertical view of upper piston rod;
Fig. 9 is the structural representation of another embodiment of the present invention;
Figure 10 is the cutaway view of another embodiment of the present invention injection tube;
Figure 11 is the structural representation of further embodiment of this invention;
Figure 12 is the cutaway view of further embodiment of this invention injection tube.
Each label is represented among the figure:
1, injection tube 2, lower piston
3, piston brace rod 4, upper piston
5, upper piston rod 6, lower chamber
7, upper chamber 8, dilute solution
9, injection medicine 10, easy broken rod
11, union joint 12, cylindrical shell epimere
13, cylindrical shell hypomere 14, sealing cap
15, syringe needle sealing shroud 16, injection needle
111, liquid outlet
31, groove 51, handle
The specific embodiment
As Fig. 1, shown in 2, two-chamber prefilled syringe of the present invention, comprise the injection tube of forming by bigger cylindrical shell epimere 12 of barrel dliameter and the less cylindrical shell hypomere 13 of barrel dliameter 1, the bottom that injection tube 1 is positioned at cylindrical shell hypomere 13 1 ends is formed with the cone-shaped union joint 11 that connects entry needle, the center of union joint 11 is provided with the liquid outlet 111 that communicates with injection tube 1 inner chamber, this liquid outlet 111 is sealed by removable sealing member, removable sealing member adopts an easy broken rod that is fractureed easily 10 in the present embodiment, this easy broken rod that is fractureed easily 10 links to each other with union joint 11, the liquid outlet 111 of union joint 11 is blocked, make it be in closed state, easy broken rod 10 is the place that fractures of easy broken rod 10 with union joint 11 joints.Easy broken rod 10 can with union joint 11 injection mouldings in one, in both joints district easy to break is set, easy broken rod 10 can be fractureed from here.The top that injection tube 1 is positioned at cylindrical shell epimere 12 1 ends is an opening; Be provided with upper piston 4 and lower piston 2 in the injection tube 1, lower piston 2 places cylindrical shell hypomere 13, and combine with the inner wall sealing of cylindrical shell hypomere 13, in injection tube 1, be separated out end face by lower piston 2, the airtight lower chamber 6 that the inwall of cylindrical shell hypomere 13 and injection tube bottom form, upper piston 4 places cylindrical shell epimere 12, and combine with the inner wall sealing of cylindrical shell epimere 12, in injection tube 1, be separated out by on, lower piston 4, the airtight upper chamber 7 that 2 relative two end faces and cylinder inboard wall are formed, lower chamber 6 and upper chamber 7 are as the storage at of prepackage injection medicine 9 with dilute solution 8, perfusion injection medicine 9 (dry shape medicine or liquid medicine) in the lower chamber 6, perfusion dilute solution 8 in the upper chamber 7.Connect by piston brace rod 3 between upper piston 4 and the lower piston 2, the end that lower piston 2 links to each other with piston brace rod 3 offers the screw (see figure 3), the two ends of upper piston 4 all offer the screw (see figure 6), the two ends of piston brace rod 3 are provided with external screw thread (seeing Fig. 4,5), piston brace rod 3 is connected with lower piston 2 with upper piston 4 by screw thread, the interlock of assurance two-piston is provided with groove 31 on the body of rod of piston brace rod 3, to increase the volume of upper chamber 7.The end that upper piston 4 is relative with injection tube 1 opening is connected with a upper piston rod 5, shown in Fig. 7,8, these upper piston rod 5 one ends are provided with external screw thread, with upper piston 4 by being threaded, the other end of upper piston rod 5 extends to outside injection tube 1 opening, supply operation usefulness, and be provided with handle 51, be convenient to injection operation in its end.Piston brace rod 3 and upper piston rod 5 adopt medical plastic to make, and upper and lower piston 4,2 adopts medical grade rubber to make.
The pre-filling injection agent medicine 9 of above-mentioned two-chamber prefilled syringe and the method for dilute solution 8 are:
1) it is big and the hypomere barrel dliameter is less and there is the injection tube 1 of a union joint 11 its bottom to produce the epimere barrel dliameter, and with set liquid outlets 111 in the union joint 11 by easy broken rod 10 sealings;
2) injection medicine 9 (dry shape medicine or liquid medicine) is poured into the less cylindrical shell hypomere 13 of barrel dliameter, can be pressed into cylindrical shell hypomere 13 with the bonded lower piston 2 of cylindrical shell hypomere 13 inner wall sealings, form the airtight lower chamber 6 that has poured into injection medicine 9, aerofluxus in the time of tamponade makes lower chamber 6 be in normal pressure and sealing;
3) piston brace rod 3 is screwed in lower piston 2, dilute solution 8 is poured in the space between piston brace rod 3 and the injection tube 1, upper piston 4 is pressed into syringe cylinder 1, and be close to piston brace rod 3, form the airtight upper chamber 7 that has poured into dilute solution 8, aerofluxus in the time of tamponade makes upper chamber 7 be in normal pressure and sealing;
4) with upper piston rod 5 and upper piston 4 by being threaded, and continue rotation, also by being threaded, so just finished the process of the prepackage injection medicine 9 and the dilute solution 8 of two-chamber prefilled syringe until upper piston 4 and piston brace rod 3.
During use, upper piston rod 5 is pulled outward, making lower piston 2 retreat to injection tube 1 upper chamber 7 by cylindrical shell hypomere 13 positions is cylindrical shell epimere 12 positions, because of the barrel dliameter of cylindrical shell epimere 12 barrel dliameter greater than cylindrical shell hypomere 13, upper and lower part chamber 7,6 intercommunications like this, thus make the dilute solution 8 in the upper chamber 7 be mixed into injection with injection medicine 9 in the lower chamber 6.This two-chamber prefilled syringe is erected, make easy broken rod 10 be in the below, injection concentrates in the cylindrical shell hypomere 13, upper piston rod 5 is pushed again, and makes lower piston 2 enter cylindrical shell hypomere 13, has finished the process of making up a prescription like this.Easy broken rod 10 is fractureed, and liquid outlet 111 is opened, and entry needle is contained in cone-shaped union joint 11 places, can carry out injection operation.
Fig. 9 shows another embodiment of the present invention, and shown in Fig. 9,10, the removable sealing member of different with the foregoing description is sealing liquid outlet 111 is a sealing cap 14, and sealing cap 14 is sheathed on the union joint 11, with set liquid outlets 111 sealings in the union joint 11.Finish make up a prescription after, sealing cap 14 is taken, entry needle is contained on the cone-shaped union joint 11, can carry out injection operation.
Figure 11 shows another embodiment of the present invention, shown in Figure 11,12, the removable sealing member of different with the foregoing description is sealing liquid outlet 111 is a syringe needle sealing shroud 15, on union joint 11, be connected with injection needle 16, this injection needle 16 can with 11 injection moldeds of union joint, syringe needle sealing shroud 15 is sheathed on the injection needle 16, with injection needle 16 sealing, also the liquid outlet 111 that is about to union joint 11 is blocked, and makes it be in closed state.Finish make up a prescription after, syringe needle sealing shroud 15 is taken, can carry out injection operation.
Claims (9)
1, a kind of two-chamber prefilled syringe, it is characterized in that it comprises the injection tube of being made up of bigger cylindrical shell epimere (12) of barrel dliameter and the less cylindrical shell hypomere (13) of barrel dliameter (1), the bottom that injection tube (1) is positioned at cylindrical shell hypomere (13) one ends is provided with union joint (11), the center of union joint (11) is provided with the liquid outlet (111) that communicates with the injection tube inner chamber, this liquid outlet (111) is sealed by removable sealing member, and the top that injection tube (1) is positioned at cylindrical shell epimere (12) one ends is an opening; Be provided with upper piston (4) and lower piston (2) in the injection tube (1), lower piston (2) places cylindrical shell hypomere (13), and combine with the inner wall sealing of cylindrical shell hypomere (13), in injection tube (1), be separated out airtight lower chamber (6), upper piston (4) places cylindrical shell epimere (12), and combine with the inner wall sealing of cylindrical shell epimere (12), in injection tube (1), be separated out airtight upper chamber (7), connect by piston brace rod (3) between upper piston (4) and the lower piston (2), the end that upper piston (4) is relative with injection tube (1) opening is connected with a upper piston rod (5), and described upper piston rod (5) extends to outside injection tube (1) opening.
2, two-chamber prefilled syringe according to claim 1, it is characterized in that described lower piston (2) offers screw with the end that piston brace rod (3) links to each other, the two ends of upper piston (4) all offer screw, the two ends of described piston brace rod (3) are provided with external screw thread, and piston brace rod (3) is connected with lower piston (2) with upper piston (4) by screw thread; Described upper piston rod (5) one ends are provided with external screw thread, with upper piston (4) by being threaded, the other end is provided with handle (51).
3, two-chamber prefilled syringe according to claim 2 is characterized in that the body of rod of described piston brace rod (3) is provided with groove (31).
4, according to claim 1 or 2 or 3 described two-chamber prefilled syringes, the removable sealing member that it is characterized in that described sealing liquid outlet (111) is an easy broken rod that is fractureed easily (10), and the described easy broken rod that is fractureed easily (10) links to each other with union joint (11).
5, according to claim 1 or 2 or 3 described two-chamber prefilled syringes, the removable sealing member that it is characterized in that described sealing liquid outlet (111) is a sealing cap (14), and described sealing cap (14) is sheathed on the union joint (11).
6, according to claim 1 or 2 or 3 described two-chamber prefilled syringes, the removable sealing member that it is characterized in that described sealing liquid outlet (111) is a syringe needle sealing shroud (15), be connected with injection needle (16) on the described union joint (11), syringe needle sealing shroud (15) is sheathed on the injection needle (16).
7,, it is characterized in that described union joint (11) is cone according to claim 1 or 2 or 3 described two-chamber prefilled syringes.
8, according to claim 1 or 2 or 3 described two-chamber prefilled syringes, it is characterized in that described piston brace rod (3) and upper piston rod (5) adopt medical plastic to make, upper and lower piston (4,2) adopts medical grade rubber to make.
9, a kind of manufacture method of two-chamber prefilled syringe as claimed in claim 1 is characterized in that:
1) it is big and the hypomere barrel dliameter is less and there is the injection tube (1) of a union joint (11) its bottom to make the epimere barrel dliameter, and set liquid outlet (111) in the union joint (11) is sealed by removable sealing member;
2) injection medicine (9) is poured into the less cylindrical shell hypomere (13) of barrel dliameter, can be pressed into cylindrical shell hypomere (13) with the bonded lower piston of cylindrical shell hypomere (13) inner wall sealing (2), form the airtight lower chamber (6) that has poured into injection medicine (9), aerofluxus in the time of tamponade makes lower chamber (6) be in normal pressure and sealing;
3) piston brace rod (3) is screwed in lower piston (2), dilute solution (8) is poured in the space between piston brace rod (3) and the injection tube (1), upper piston (4) is pressed into syringe cylinder (1), and be close to piston brace rod (3), form the airtight upper chamber (7) that has poured into dilute solution (8), aerofluxus in the time of tamponade makes upper chamber (7) be in normal pressure and sealing;
4) with upper piston rod (5) and upper piston (4) by being threaded, and continue rotation, also by being threaded, promptly make two-chamber prefilled syringe until upper piston (4) and piston brace rod (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100324622A CN100368030C (en) | 2005-11-30 | 2005-11-30 | Two-chamber prefilled syringe and its prefilling method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100324622A CN100368030C (en) | 2005-11-30 | 2005-11-30 | Two-chamber prefilled syringe and its prefilling method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1775317A true CN1775317A (en) | 2006-05-24 |
| CN100368030C CN100368030C (en) | 2008-02-13 |
Family
ID=36765113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100324622A Expired - Fee Related CN100368030C (en) | 2005-11-30 | 2005-11-30 | Two-chamber prefilled syringe and its prefilling method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100368030C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921071A (en) * | 2012-10-30 | 2013-02-13 | 无锡耐思生物科技有限公司 | Mixing and prefilling syringe structure |
| CN102935255A (en) * | 2012-10-30 | 2013-02-20 | 无锡耐思生物科技有限公司 | Pre-filling-and-sealing syringe structure for mixing |
| CN106345011A (en) * | 2016-09-29 | 2017-01-25 | 宋占涛 | Isolation plug, prefilled syringe provided with isolation plug and isolation method |
| CN110811906A (en) * | 2019-11-21 | 2020-02-21 | 江苏农牧科技职业学院 | Medical advanced immunization device for pseudorabies of piglets in positive pig farm |
| CN114538590A (en) * | 2022-03-01 | 2022-05-27 | 宿州汉泰化工有限公司 | Phosphorus trichloride production sewage recovery processing equipment |
| CN115607444A (en) * | 2022-09-30 | 2023-01-17 | 湛江健力源医疗用品有限公司 | Closed liquid medicine transfer device and liquid medicine transfer system with double indoor circulation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211285A (en) * | 1992-03-19 | 1993-05-18 | Habley Medical Technology Corporation | Telescoping, pharmaceutical mixing container |
| CA2440889A1 (en) * | 2001-03-13 | 2002-09-19 | Mdc Investment Holdings, Inc. | Pre-filled safety diluent injector |
| ES2530517T3 (en) * | 2003-02-19 | 2015-03-03 | Takeda Pharmaceutical | Prefilled syringe of double chamber type |
| CN2631522Y (en) * | 2003-06-17 | 2004-08-11 | 吴月波 | Powder injection syringe |
| CN2843489Y (en) * | 2005-12-01 | 2006-12-06 | 湖南千山制药机械股份有限公司 | Pre-filled syringe with double chambers |
-
2005
- 2005-11-30 CN CNB2005100324622A patent/CN100368030C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921071A (en) * | 2012-10-30 | 2013-02-13 | 无锡耐思生物科技有限公司 | Mixing and prefilling syringe structure |
| CN102935255A (en) * | 2012-10-30 | 2013-02-20 | 无锡耐思生物科技有限公司 | Pre-filling-and-sealing syringe structure for mixing |
| CN102935255B (en) * | 2012-10-30 | 2015-01-21 | 无锡耐思生物科技有限公司 | Pre-filling-and-sealing syringe structure for mixing |
| CN106345011A (en) * | 2016-09-29 | 2017-01-25 | 宋占涛 | Isolation plug, prefilled syringe provided with isolation plug and isolation method |
| CN110811906A (en) * | 2019-11-21 | 2020-02-21 | 江苏农牧科技职业学院 | Medical advanced immunization device for pseudorabies of piglets in positive pig farm |
| CN110811906B (en) * | 2019-11-21 | 2021-10-15 | 江苏农牧科技职业学院 | A pre-immunization device for pseudorabies in piglets in a medical-positive pig farm |
| CN114538590A (en) * | 2022-03-01 | 2022-05-27 | 宿州汉泰化工有限公司 | Phosphorus trichloride production sewage recovery processing equipment |
| CN115607444A (en) * | 2022-09-30 | 2023-01-17 | 湛江健力源医疗用品有限公司 | Closed liquid medicine transfer device and liquid medicine transfer system with double indoor circulation |
| CN115607444B (en) * | 2022-09-30 | 2023-05-02 | 湛江健力源医疗用品有限公司 | Double-indoor circulation closed type liquid medicine transfer device and liquid medicine transfer system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100368030C (en) | 2008-02-13 |
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