CN1742788A - Inflammation-diminishing detoxifying preparation and new preparing method - Google Patents
Inflammation-diminishing detoxifying preparation and new preparing method Download PDFInfo
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Abstract
The prescription of Chinese medicine for curing skin and external diseases including carbuncle, deep-rooted carbuncle, furuncle, multiple abscess, scrofula and ulcer, female mastitis and infantile furuncle and sore includes the Chinese medicinal material dandelion 800 portions, ledebouriella root 10 portions, licorice 20 portions, forsythia fruit 20 portions and lonicera flower 20 portions. Said preparation can be made into various dosage forms of dripping pills and soft capsule, etc.
Description
Technical field:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, particularly a kind of treatment heat-virulence in a sore, congestion and swelling pain, women's breast ulcer, the preparation recipe of children's's furuncle and preparation technology thereof.
Background technology:
For a long time, account for 75% of whole infectious disease by the infectious disease due to the viral infection, what have causes popular even is very popular.The infection rate in the crowd that has is very high, as HBV, and AIDS, some case fatality rate is very high; Even extremely often do not stay sequela yet; Some then forms persistent infection, sends out infection slowly, and some causes tumor.Therefore virus is very close with human relation.Along with science and technology development, the raising of virus detection techniques, new virus is still in continuous discovery, and constantly perplexs the patient, brings great mental burden and financial burden to the patient.
We's Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dampness removing is treating stranguria; The Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens; The Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; Merge Radix Saposhnikoviae, Radix Glycyrrhizae, play heat-clearing and toxic substances removing altogether, the effect of removing heat from blood antiinflammatory.Preparation behind the change preparation technology is easy to dissolving and absorption than elite and thick putting that previous technology more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, efficient, low dosage, the Chinese medicine preparation that has no side effect and preparation technology thereof.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is made up of following proportion raw material and adjuvant:
9～58 parts in 4.5～29 portions of Radix Glycyrrhizaes of 362～2345 parts of Radix Saposhnikoviaes of Herba Taraxaci
9～58 parts of 9～58 portions of Flos Loniceraes of Fructus Forsythiae
Preferably:
20 parts in 10 portions of Radix Glycyrrhizaes of 800 parts of Radix Saposhnikoviaes of Herba Taraxaci
20 parts of 20 portions of Flos Loniceraes of Fructus Forsythiae
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, granule 1000g etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50-1000 taking dose,, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
Pharmaceutical preparation of the present invention can be made into any dosage form that is fit to take, preferably: drop pill, soft capsule, granule, chewable tablet, tablet, capsule, pill.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
The above new technology of the present invention may further comprise the steps:
Method a:
(1) get Fructus Forsythiae, take steam distillation that its volatile oil is extracted, no longer increase (extracting approximately 8 hours) to oil reservoir, the about 0.64g of volatile oil (by 4% content); Oil (1) is with β-CD (8) enclose, standby;
(2) get four Chinese medicine materials such as Herba Taraxaci, boiled 2 hours, 1.5 hours, 1.5 hours with the decocting of 8 times of amounts, 6 times of amounts, 6 times of amounts, merge extractive liquid,, concentrating under reduced pressure become thick paste, and be standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) get Herba Taraxaci 590g, decoct with water secondary, each 2 hours, collecting decoction filtered, and filtrate is condensed into cream, and is standby;
(2) four flavors such as residue Herba Taraxaci and other Flos Loniceraes are ground into fine powder, add (to reserve an amount of condensed cream powder and make coating usefulness) mixing in the condensed cream, and drying is ground into fine powder, sieves, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, perhaps their mixture or other suitable other auxiliary elements such as glycerol, gelatin or stearic acid sodium etc. of making drop pill.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2.Wherein the weight proportion between active component and the pharmaceutically useful organic solvent is: the content of active component is 50mg-500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation such as granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
(1) antiinflammatory test
1, to the influence of rat paw edema due to the Ovum Gallus domesticus album
Get 40 of rats, male and female half and half, body weight 120-150g is divided into 4 groups at random, promptly normal saline group, technology 1. extractum group, technology 2. extractum group and QIANGLI YINQIAO PIAN group dosage see Table 1, administering mode is irritated stomach, each organizes administration every day 3 times, successive administration 4d.Measurement is respectively organized the left back sufficient sole of the foot volume of rat as causing scorching preceding normal foot sole of the foot volume before the last administration, and 30min in left back sufficient sole of the foot Se fresh albumen 0.05ml only after administration
-1Behind albumen injection 0.5,1,2,4 and 6h respectively survey sufficient sole of the foot volume 1 time, the record respectively organize measurement data and carry out statistical procedures.
The influence of rat paw edema due to the table 1 pair Ovum Gallus domesticus album
Group dosage causes scorching back different time pedal swelling rate (%)
(g/kg) 0.5h 1h 2h 4h 6h
Normal saline group-45.53 ± 5.44 59.22 ± 5.12 63.02 ± 4.82 58.50 ± 5.23 54.97 ± 6.05
Technology is extractum group 0.62 39.19 ± 6.20 1.
*52.30 ± 4.97
*57.50 ± 5.07
*53.55 ± 4.75
*50.56 ± 5.77
Technology is extractum group 0.74 40.22 ± 5.04 2.
*54.21 ± 5.37
*58.27 ± 5.03
*54.07 ± 6.20 5203 ± 5.80
QIANGLI YINQIAO PIAN group 0.45 37.62 ± 4.93
*51.59 ± 5.75
*55.64 ± 6.24
*53.47 ± 4.83
*49.51 ± 5.44
*
Compare with matched group
*P＜0.01,
*P＜0.05
Result of the test shows, the rat paw edema that two administration groups cause Ovum Gallus domesticus album has obvious inhibitory action, and technology 1. extractum group is causing scorching back 0.Sh～4h effect obviously, and swelling rate and matched group comparing difference have significance; Technology 2. extractum group is causing inflammation back 0.5h, 1h, 2h effect obviously, and swelling rate and matched group comparing difference have significance.
2, the influence of xylol induced mice ear swelling
Get 40 of mices, male, body weight 18-22g is divided into 4 groups at random, 10 every group.Be normal saline group, technology 1. extractum group, technology 2. extractum group and QIANGLI YINQIAO PIAN group dosage see Table 1, administering mode is irritated stomach, each organizes administration every day 3 times, successive administration 4d.1h under etherization is coated in two sides, ear front and back, a mice left side with dimethylbenzene 0.02mL and causes inflammation after the last administration, causes scorching back 30min mice is put to death, and lays auricle with 7mm diameter card punch in mice left and right sides ear same area, uses scales/electronic balance weighing.Record left and right sides auricle weight is calculated the swelling rate, carries out statistical procedures by the t method of inspection.
The bullate influence of table 2 xylol induced mice ear
Group dosage (g/kg) number of animals swelling rate (%)
Normal saline group-10 58.39 ± 8.60
Technology is extractum group 1.23 10 49.50 ± 9.20 1.
*
Technology is extractum group 1.48 10 48.32 ± 11.47 2.
*
QIANGLI YINQIAO PIAN group 0.9 10 43.75 ± 9.43
*
By data in the table as can be known, technology 1. extractum group and technology 2. the mice ear due to the extractum group xylol certain inhibitory action is arranged, with matched group comparison swelling rate difference significance is arranged.
(2) toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment heat-virulence in a sore, congestion and swelling pain, women's breast ulcer, the medicine of children's's furuncle, and change preparation technology, can obviously strengthen its heat-clearing and toxic substances removing, clinical efficacies such as removing heat from blood antiinflammatory do not have tangible toxicity, prolonged application safety in addition, therefore, being worth clinical further applies.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Herba Taraxaci 470.6g Radix Saposhnikoviae 5.9g Radix Glycyrrhizae 11.8g
Fructus Forsythiae 11.8g Flos Lonicerae 11.8g PEG400 100G
Make 1000 balls
Preparation method:
Get Fructus Forsythiae, take steam distillation that its volatile oil is extracted, no longer increase (extracting approximately 8 hours) to oil reservoir, the about 0.64g of volatile oil (by 4% content); Oil (1) is with β-CD (8) enclose, standby; Get four Chinese medicine materials such as Herba Taraxaci, boiled 2 hours, 1.5 hours, 1.5 hours with the decocting of 8 times of amounts, 6 times of amounts, 6 times of amounts, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby; With above-mentioned extract obtained, the PEG400 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Herba Taraxaci 2345g Radix Saposhnikoviae 29g Radix Glycyrrhizae 58g
Fructus Forsythiae 58g Flos Lonicerae 58g PEG400500g
Make 1000
Preparation method:
Get Fructus Forsythiae, take steam distillation that its volatile oil is extracted, no longer increase (extracting approximately 8 hours) to oil reservoir, the about 0.64g of volatile oil (by 4% content); Oil (1) is with β-CD (8) enclose, standby; Get four Chinese medicine materials such as Herba Taraxaci, boiled 2 hours, 1.5 hours, 1.5 hours with the decocting of 8 times of amounts, 6 times of amounts, 6 times of amounts, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby; With above-mentioned extract obtained, add an amount of PEG400 mixing and pulverizing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable splashes in the coolant (liquid paraffin), promptly.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Herba Taraxaci 1600g Radix Saposhnikoviae 20g Radix Glycyrrhizae 40g
Fructus Forsythiae 40g Flos Lonicerae 40g
Make 1000g
Preparation method:
Get Herba Taraxaci 1180g, decoct with water secondary, each 2 hours, collecting decoction filtered, and filtrate is condensed into cream, and is standby; Four flavors such as residue Herba Taraxaci and other Flos Loniceraes are ground into fine powder, add (to reserve an amount of condensed cream powder and make coating usefulness) mixing in the condensed cream, and drying is ground into fine powder, sieves, and is standby; Add aspartame 5.0g, dextrin 200.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Herba Taraxaci 362g Radix Saposhnikoviae 4.5g Radix Glycyrrhizae 9g
Fructus Forsythiae 9g Flos Lonicerae 9g
Make 1000
Preparation method:
Get Herba Taraxaci 267g, decoct with water secondary, each 2 hours, collecting decoction filtered, and filtrate is condensed into cream, and is standby; Four flavors such as residue Herba Taraxaci and other Flos Loniceraes are ground into fine powder, add (to reserve an amount of condensed cream powder and make coating usefulness) mixing in the condensed cream, and drying is ground into fine powder, sieves, and is standby; With above-mentioned extract obtained fine powder, sieve, use the water pill drying, with the condensed cream powder coating of reserving, polishing, drying, promptly.
Claims (10)
1, a kind of Chinese medicine composition is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
9～58 parts in 4.5～29 portions of Radix Glycyrrhizaes of 362～2345 parts of Radix Saposhnikoviaes of Herba Taraxaci
9～58 parts of 9～58 portions of Flos Loniceraes of Fructus Forsythiae
2, the compound preparation of claim 1～2 is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
20 parts in 10 portions of Radix Glycyrrhizaes of 800 parts of Radix Saposhnikoviaes of Herba Taraxaci
20 parts of 20 portions of Flos Loniceraes of Fructus Forsythiae
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Fructus Forsythiae, take steam distillation that its volatile oil is extracted, no longer increase (extracting approximately 8 hours) to oil reservoir, the about 0.64g of volatile oil (by 4% content); Oil (1) is with β-CD (8) enclose, standby;
(2) get four Chinese medicine materials such as Herba Taraxaci, boiled 2 hours, 1.5 hours, 1.5 hours with the decocting of 8 times of amounts, 6 times of amounts, 6 times of amounts, merge extractive liquid,, concentrating under reduced pressure become thick paste, and be standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:(technology 2.)
(1) get Herba Taraxaci 590g, decoct with water secondary, each 2 hours, collecting decoction filtered, and filtrate is condensed into cream, and is standby;
(2) four flavors such as residue Herba Taraxaci and other Flos Loniceraes are ground into fine powder, add (to reserve an amount of condensed cream powder and make coating usefulness) mixing in the condensed cream, and drying is ground into fine powder, sieves, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
6, the Chinese medicine preparation of claim 5, it is characterized in that: described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that: described soft capsule, and its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of granule is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of correctives, filler, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that: described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1-9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:
(1) get Fructus Forsythiae, take steam distillation that its volatile oil is extracted, no longer increase (extracting approximately 8 hours) to oil reservoir, the about 0.64g of volatile oil (by 4% content); Oil (1) is with β-CD (8) enclose, standby;
(2) get four Chinese medicine materials such as Herba Taraxaci, boiled 2 hours, 1.5 hours, 1.5 hours with the decocting of 8 times of amounts, 6 times of amounts, 6 times of amounts, merge extractive liquid,, concentrating under reduced pressure become thick paste, and be standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) get Herba Taraxaci 590g, decoct with water secondary, each 2 hours, collecting decoction filtered, and filtrate is condensed into cream, and is standby;
(2) four flavors such as residue Herba Taraxaci and other Flos Loniceraes are ground into fine powder, add (to reserve an amount of condensed cream powder and make coating usefulness) mixing in the condensed cream, and drying is ground into fine powder, sieves, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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|---|---|---|---|
| CN 200510105353 CN1742788A (en) | 2005-09-23 | 2005-09-23 | Inflammation-diminishing detoxifying preparation and new preparing method |
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|---|---|---|---|
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8042282B2 (en) | 2006-02-27 | 2011-10-25 | Lg Electronics Inc. | Drum for clothes dryer |
| CN103919860A (en) * | 2014-04-14 | 2014-07-16 | 海南葫芦娃制药有限公司 | Honeysuckle cold curing granule and preparation method thereof |
| CN104208293A (en) * | 2014-09-13 | 2014-12-17 | 吕银兰 | Granule capable of clearing away heat and toxic materials |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
| CN105748599A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for eliminating inflammations and detoxifying, and preparation method thereof |
| CN112717030A (en) * | 2021-01-26 | 2021-04-30 | 成都中医药大学附属医院 | Pharmaceutical composition for preventing and treating oral diseases and preparation method and application thereof |
| CN114009639A (en) * | 2021-11-17 | 2022-02-08 | 宁夏学林商贸有限公司 | A Chinese medicinal health beverage and its preparation method |
| CN115518095A (en) * | 2022-10-09 | 2022-12-27 | 张沙沙 | Dandelion paste and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8042282B2 (en) | 2006-02-27 | 2011-10-25 | Lg Electronics Inc. | Drum for clothes dryer |
| CN103919860A (en) * | 2014-04-14 | 2014-07-16 | 海南葫芦娃制药有限公司 | Honeysuckle cold curing granule and preparation method thereof |
| CN103919860B (en) * | 2014-04-14 | 2016-08-17 | 海南葫芦娃药业集团股份有限公司 | Honeysuckle flower common cold granule and preparation method thereof |
| CN104208293A (en) * | 2014-09-13 | 2014-12-17 | 吕银兰 | Granule capable of clearing away heat and toxic materials |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
| CN105748599A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for eliminating inflammations and detoxifying, and preparation method thereof |
| CN112717030A (en) * | 2021-01-26 | 2021-04-30 | 成都中医药大学附属医院 | Pharmaceutical composition for preventing and treating oral diseases and preparation method and application thereof |
| CN112717030B (en) * | 2021-01-26 | 2022-05-17 | 成都中医药大学附属医院 | Pharmaceutical composition for preventing and treating oral diseases and preparation method and application thereof |
| CN114009639A (en) * | 2021-11-17 | 2022-02-08 | 宁夏学林商贸有限公司 | A Chinese medicinal health beverage and its preparation method |
| CN115518095A (en) * | 2022-10-09 | 2022-12-27 | 张沙沙 | Dandelion paste and preparation method thereof |
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