CN1626168A - Leadwort (white snowflake) preparation - Google Patents
Leadwort (white snowflake) preparation Download PDFInfo
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- CN1626168A CN1626168A CN 200310111113 CN200310111113A CN1626168A CN 1626168 A CN1626168 A CN 1626168A CN 200310111113 CN200310111113 CN 200310111113 CN 200310111113 A CN200310111113 A CN 200310111113A CN 1626168 A CN1626168 A CN 1626168A
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- Prior art keywords
- plumbagin
- medicinal
- medicine
- pills
- soap
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- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 241000533950 Leucojum Species 0.000 title description 6
- 241000209454 Plumbaginaceae Species 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 20
- VCMMXZQDRFWYSE-UHFFFAOYSA-N plumbagin Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1O VCMMXZQDRFWYSE-UHFFFAOYSA-N 0.000 claims abstract description 20
- LHPOSZYLQOYNDN-UHFFFAOYSA-N 3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C)=C(Cl)C(=O)C2=C1O LHPOSZYLQOYNDN-UHFFFAOYSA-N 0.000 claims abstract description 12
- ZMOIGGHUSNHCAB-UHFFFAOYSA-N Isoplumbagin Natural products C1=CC(O)=C2C(=O)C(C)=CC(=O)C2=C1 ZMOIGGHUSNHCAB-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000006187 pill Substances 0.000 claims abstract description 12
- ALPCEXCHMFUSAN-UHFFFAOYSA-N beta-Dihydroplumbagin Natural products C1=CC=C2C(=O)C(C)CC(=O)C2=C1O ALPCEXCHMFUSAN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000344 soap Substances 0.000 claims abstract description 10
- 230000008961 swelling Effects 0.000 claims abstract description 8
- 241001290168 Plumbago zeylanica Species 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 5
- OPOVMNDABAKVQM-UHFFFAOYSA-N Plumbagic acid Natural products CC(CC(=O)c1cccc(O)c1O)C(=O)O OPOVMNDABAKVQM-UHFFFAOYSA-N 0.000 claims abstract description 5
- 208000002474 Tinea Diseases 0.000 claims abstract description 5
- 241000893966 Trichophyton verrucosum Species 0.000 claims abstract description 5
- 229940040145 liniment Drugs 0.000 claims abstract description 5
- 239000000865 liniment Substances 0.000 claims abstract description 5
- 230000003211 malignant effect Effects 0.000 claims abstract description 5
- 239000000443 aerosol Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000007919 dispersible tablet Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 239000007924 injection Substances 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims abstract description 4
- 239000002674 ointment Substances 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000007901 soft capsule Substances 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims abstract description 4
- 239000006188 syrup Substances 0.000 claims abstract description 4
- 235000020357 syrup Nutrition 0.000 claims abstract description 4
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 229940098465 tincture Drugs 0.000 claims abstract description 4
- 229940034610 toothpaste Drugs 0.000 claims abstract description 4
- 239000000606 toothpaste Substances 0.000 claims abstract description 4
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims abstract description 4
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229930091371 Fructose Natural products 0.000 claims abstract description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 3
- 239000005715 Fructose Substances 0.000 claims abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 3
- 108091005804 Peptidases Proteins 0.000 claims abstract description 3
- 239000004365 Protease Substances 0.000 claims abstract description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 3
- 239000008103 glucose Substances 0.000 claims abstract description 3
- 235000011073 invertase Nutrition 0.000 claims abstract description 3
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims abstract description 3
- -1 tincture Substances 0.000 claims abstract 7
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims abstract 4
- 241000196324 Embryophyta Species 0.000 claims abstract 4
- 239000004480 active ingredient Substances 0.000 claims abstract 3
- 238000001802 infusion Methods 0.000 claims abstract 3
- 239000006210 lotion Substances 0.000 claims abstract 3
- 239000011505 plaster Substances 0.000 claims abstract 3
- 208000034656 Contusions Diseases 0.000 claims abstract 2
- 206010033425 Pain in extremity Diseases 0.000 claims abstract 2
- 101710184309 Probable sucrose-6-phosphate hydrolase Proteins 0.000 claims abstract 2
- 102400000472 Sucrase Human genes 0.000 claims abstract 2
- 101710112652 Sucrose-6-phosphate hydrolase Proteins 0.000 claims abstract 2
- 229940076810 beta sitosterol Drugs 0.000 claims abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract 2
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims abstract 2
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims abstract 2
- 229930182478 glucoside Natural products 0.000 claims abstract 2
- 150000008131 glucosides Chemical class 0.000 claims abstract 2
- 210000004400 mucous membrane Anatomy 0.000 claims abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract 2
- 229950005143 sitosterol Drugs 0.000 claims abstract 2
- 229930182470 glycoside Natural products 0.000 claims description 3
- 150000002338 glycosides Chemical class 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 244000269722 Thea sinensis Species 0.000 claims 2
- 235000001553 Betula platyphylla Nutrition 0.000 claims 1
- 241001313086 Betula platyphylla Species 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 208000002193 Pain Diseases 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000002040 relaxant effect Effects 0.000 abstract description 3
- 210000002435 tendon Anatomy 0.000 abstract description 3
- LINMATFDVHBYOS-RKQHYHRCSA-N (2s,3r,4s,5s,6r)-2-[(5-bromo-1h-indol-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C=C12 LINMATFDVHBYOS-RKQHYHRCSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000004438 eyesight Effects 0.000 abstract 1
- 235000001727 glucose Nutrition 0.000 abstract 1
- 235000013616 tea Nutrition 0.000 abstract 1
- 239000002966 varnish Substances 0.000 abstract 1
- 208000008035 Back Pain Diseases 0.000 description 3
- 208000008930 Low Back Pain Diseases 0.000 description 3
- 230000006735 deficit Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 201000003068 rheumatic fever Diseases 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- CQDXJBJBEQPBEM-UHFFFAOYSA-N Droserone Chemical compound C1=CC=C2C(=O)C(C)=C(O)C(=O)C2=C1O CQDXJBJBEQPBEM-UHFFFAOYSA-N 0.000 description 2
- 241000201295 Euphrasia Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000903946 Clematidis Species 0.000 description 1
- 241001136643 Gelsemium sempervirens Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 241000209456 Plumbago Species 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 235000015091 medicinal tea Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
一种治疗肿瘤、癣症、皮肤及粘膜肿毒恶疮、跌打劳伤、风湿性关节炎、腰腿疼等症的新中药及民族药。舒筋活血、祛风止痛、散淤消肿、明目等功效，疗效显著。该药以蓝雪科蓝雪属白雪花Plumbago zeylanica L.的全草、根、叶及其有效成分蓝雪苷(甙)、矶松素(Plumbagin)、β－谷甾醇、香草酸(Vanillicacid)、白花丹酸(Plumbagic acid)、3－氯矶松素(3－chloro plumbagin)、3，3－双矶松素、白花丹酮、异白花丹酮、茅膏醌、白花丹醌、蛋白酶、蔗糖酶、葡萄糖、果糖等入药的散剂、丸剂、浓缩丸、片剂、分散片、胶囊剂、软胶囊剂、颗粒剂、糖浆剂、口服液、注射液、大输液、滴丸、茶剂、酒剂、喷雾剂、气雾剂、软膏剂、搽剂、贴膏剂、酊剂、涂膜剂、巴布剂、洗液、沐浴液、药用香皂、药用肥皂、药用牙膏等制剂。A new traditional Chinese medicine and national medicine for treating tumors, ringworm, skin and mucous membrane swelling and malignant sores, bruises, rheumatoid arthritis, waist and leg pain, etc. It has the effects of relaxing tendons and activating blood circulation, dispelling wind and relieving pain, dissipating stasis and reducing swelling, improving eyesight, etc., and the curative effect is remarkable. The medicine is composed of the whole plant, root and leaf of Plumbago zeylanica L., and its active ingredients blue glucoside (glucoside), Plumbagin, β-sitosterol and vanillic acid. , Plumbagic acid (Plumbagic acid), 3-chloro plumbagin (3-chloro plumbagin), 3,3-bis-chloroplumbagin, plumbagin, iso-plumbagin, quinone, plumbagin, protease, Powders, pills, concentrated pills, tablets, dispersible tablets, capsules, soft capsules, granules, syrups, oral liquids, injections, large infusions, dripping pills, teas, sucrase, glucose, fructose, etc. Liquor, spray, aerosol, ointment, liniment, plaster, tincture, varnish, cataplasm, lotion, body wash, medicinal soap, medicinal soap, medicinal toothpaste and other preparations.
Description
The invention belongs to Chinese medicine and national medicine technical field, relate to a kind of Chinese medicine and ethnic drug for the treatment of diseases such as tumor, ringworm, skin and mucosa toxic swelling malignant boil, traumatic injury impairment caused by overstrain, rheumatic arthritis, lumbago and skelalgia.
The Chinese medicine and the ethnic drug for the treatment of diseases such as tumor, ringworm, skin and mucosa toxic swelling malignant boil, traumatic injury impairment caused by overstrain, rheumatic arthritis, lumbago and skelalgia in the prior art are of a great variety, the effect of medicine is variant, retrieve through Chinese patent literature, have only and contain this flavor medical material of Radix Plumbaginis Zeylanicae in 2 patent prescriptions, degree of correlation is A (not influencing the application).None example is identical with the present invention.
The object of the present invention is to provide a kind of new Chinese medicine and ethnic drug for the treatment of diseases such as tumor, ringworm, skin and mucosa toxic swelling malignant boil, traumatic injury impairment caused by overstrain, rheumatic arthritis, lumbago and skelalgia.Relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping, dissipating blood stasis for subsidence of swelling, effect such as make eye bright, evident in efficacy.
Realize that the object of the invention technical scheme is: the herb that belongs to white snowflake Plumbago zeylanicaL. with the blue snow of lumbaginaceae, root, leaf and effective ingredient Plumbaginaceae glycoside (glycoside) thereof, plumbagin (Plumbagin), cupreol, vanillic acid (Vanillic acid), plumbagic acid (Plumbagic acid), 3-chloroplumbagin (3-chloroplumbagin), 3, the 3-biplumbagin, Radix Plumbaginis Zeylanicae ketone, different Radix Plumbaginis Zeylanicae ketone, droserone, plumbagin, protease, saccharase, glucose, the powder that fructose etc. are used as medicine, pill, concentrated pill, tablet, dispersible tablet, capsule, soft capsule, granule, syrup, oral liquid, injection, infusion solutions, drop pill, medicinal tea, medicated wine, spray, aerosol, ointment, liniment, emplastrum, tincture, liniment, cataplasma, washing liquid, bath foam, medicinal fancy soap, medicinal soap, preparations such as medicinal toothpaste.
Radix Plumbaginis Zeylanicae is that herb, root, the leaf that the blue snow of lumbaginaceae belongs to white snowflake Plumbago zeylanica L. is used as medicine.Medical material claims white snowflake, Radix Clematidis terniflorae again, spends the spun gold Rhizoma Rodgersiae in vain, spends JIUGUNIU in vain, spends the building root in vain, white soap medicine, mountain ripple Siberian cocklebur, see and disappear, Wu Mianma, fiery miracle, false jasmine, violent tiger, spend Rhizoma Rodgersiae in vain.Effect such as effect is relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping, dissipating blood stasis for subsidence of swelling, make eye bright, evident in efficacy.
The blue snow of lumbaginaceae is belonged to herb, root, leaf and the effective ingredient thereof of white snowflake Plumbago zeylanica L., by different treatment objectives carry out in the pharmacology body, in-vitro screening, selects different dosage forms, heighten the effect of a treatment reduction toxicity or remove toxicity.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310111113 CN1626168A (en) | 2003-12-08 | 2003-12-08 | Leadwort (white snowflake) preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310111113 CN1626168A (en) | 2003-12-08 | 2003-12-08 | Leadwort (white snowflake) preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1626168A true CN1626168A (en) | 2005-06-15 |
Family
ID=34759325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310111113 Pending CN1626168A (en) | 2003-12-08 | 2003-12-08 | Leadwort (white snowflake) preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1626168A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455783B (en) * | 2008-12-05 | 2011-03-02 | 包头市红卫日用化工有限公司 | Rheumatism pain-alleviating soap and preparation method thereof |
| CN101757057B (en) * | 2009-11-13 | 2013-11-06 | 秦大伟 | Whiteflower leadword root chewable tablet |
| US20160184380A1 (en) * | 2010-11-13 | 2016-06-30 | Sirbal Ltd. | Molecular Combinations for Cancer or Other Disease Treatment |
| CN109651220A (en) * | 2018-12-25 | 2019-04-19 | 浙江省化工研究院有限公司 | A kind of plumbagin selenium ester derivative and its preparation method and application |
| CN113730379A (en) * | 2021-09-24 | 2021-12-03 | 海南师范大学 | Cataplasm containing Plumbum preparatium extract and its preparation method |
-
2003
- 2003-12-08 CN CN 200310111113 patent/CN1626168A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455783B (en) * | 2008-12-05 | 2011-03-02 | 包头市红卫日用化工有限公司 | Rheumatism pain-alleviating soap and preparation method thereof |
| CN101757057B (en) * | 2009-11-13 | 2013-11-06 | 秦大伟 | Whiteflower leadword root chewable tablet |
| US20160184380A1 (en) * | 2010-11-13 | 2016-06-30 | Sirbal Ltd. | Molecular Combinations for Cancer or Other Disease Treatment |
| CN109651220A (en) * | 2018-12-25 | 2019-04-19 | 浙江省化工研究院有限公司 | A kind of plumbagin selenium ester derivative and its preparation method and application |
| CN109651220B (en) * | 2018-12-25 | 2020-08-07 | 浙江省化工研究院有限公司 | Lanceoquinone selenium ester derivative and preparation method and application thereof |
| CN113730379A (en) * | 2021-09-24 | 2021-12-03 | 海南师范大学 | Cataplasm containing Plumbum preparatium extract and its preparation method |
| CN113730379B (en) * | 2021-09-24 | 2023-12-12 | 海南师范大学 | Cataplasm containing Plumbum Preparatium extract and its preparation method |
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| C06 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |