CN1626143A - Medication for treating pharyngitis - Google Patents
Medication for treating pharyngitis Download PDFInfo
- Publication number
- CN1626143A CN1626143A CNA2003101073020A CN200310107302A CN1626143A CN 1626143 A CN1626143 A CN 1626143A CN A2003101073020 A CNA2003101073020 A CN A2003101073020A CN 200310107302 A CN200310107302 A CN 200310107302A CN 1626143 A CN1626143 A CN 1626143A
- Authority
- CN
- China
- Prior art keywords
- add
- adjuvant
- ethanol
- water
- adds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
A medicine for treating pharyngitis is disclosed. Its advantages are high safety and lower toxic by-effect.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of pharyngitis, specifically it is to be the pharmaceutical preparation that is used for the treatment of pharyngitis that raw material is made with the Chinese herbal medicine.
Background technology
Pharyngitis is the disease of respiratory tract, is a kind of commonly encountered diseases.Modern medicine is divided into acute and chronic two kinds to primary disease, acute pharyngitis show effect repeatedly or since environment in some factor long-time stimulus can transfer chronic pharyngitis to.Chinese medicine thinks that primary disease is many by wind-heat evil toxin invasion and attack bottleneck throat, or the stomach mansion have hot and suffocating, the upper punch throat, or hyperactivity of deficient fire causes, and common sympton is that the acute pharyngitis onset is more anxious, the first pharyngeal drying of time-out, scorching hot, then pharyngalgia occurs, often more obvious than when feed when swallowing saliva, saliva is increased, General Symptoms is generally lighter, and heating, headache, inappetence and extremities aching pain etc. can be arranged.Transfer the visible pharyngeal chronic congestion that is after the chronic pharyngitis to, pharyngeal have various uncomfortable sensations, as itch, scorching hot, dry, foreign body sensation etc.The secretions thickness often invests the pharynx rear wall.Hoarseness, Chang Yichen rise attaches most importance to, the thick even aphonia of sound.
Therapeutic Method commonly used clinically at present is a topical therapeutic, and local method of treatment comprises (1) rinsing the mouth method: medicine commonly used has Dobell's solution, furacilin solution, hibitane collutory etc., and the rinsing the mouth method can only act on before the isthmus faucium, and pharynx rear wall and sidewall difficulty touch.(2) buccal tablet: be the most frequently used method, medicine commonly used has domiphen bromide buccal tablet, tabellae iodi gurgitis, tabellae menthae gurgitis, lysozyme sheet, pills for throat disease, LIUSHEN WAN, watermelon crystal buccal tablet, Herba Pileae Scriptae Tabellae etc., though the ingredient of this type of buccal tablet can directly act on oral cavity, isthmus faucium, pharynx wall and laryngopharynx portion mucosa, but drug releasing rate is slower, and onset is slower.(3) coating method: medicine commonly used has glycerinum iodi compositum, boric acid glycerin, compound recipe Herba Menthae wet goods, and this type of easily is dropped into throat, causes the irritative cough.(4) insufflation therapy: common drug such as sodium cromoglicate, inferior carbonic acid sulfathiazole powder, and the Chinese medicine SHANGLIAOHOUFENG SAN etc., this type of medicine mostly is powder, and easily causing chokes coughs.(5) nebulization: be the better administering mode that gets, but medicine commonly used at present mostly is topical anesthetic cream, can not fundamentally solve pharyngitis; (6) aerosol rebreathing method or smoked gas Fa Changyin high temperature destroy composition in the medicinal liquid, or are difficult to promote because of the ultrasonic atomizatio inhaler is more expensive.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of treatment pharyngitis with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of pharyngitis pharmaceutical preparation.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Be chosen as 2～4 parts of the Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials of preferred drug component consumption of the present invention and adjuvant thereof are made, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as 3.33 parts of the Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a): it is standby to get 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 10～30 times, 5～15 times moisture and got indescribably 0.5～3 hour, 0.5～2 hour, filter, merging filtrate is condensed into cream, add 4～12 times of 80～99% ethanol, 2～10 times of precipitate with ethanol 1～3 time, get supernatant and reclaim ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 2～6 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 2～4 times extracted 1～4 hour at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stir; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～120 minute; insulation; be 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore and splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a): it is standby to get 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 15～25 times, 8～12 times moisture and got indescribably 1～2 hour, 0.75～1.5 hour, filter, merging filtrate is condensed into cream, add 6～10 times of 90～97% ethanol, 4～6 times of precipitate with ethanol 2 times, get supernatant and reclaim ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 3～5 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 1.5～3.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 1.5～3.5 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Best preparation method comprises the following steps:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir, mixing time is 10～30 minutes, insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the ratio of getting weight is 1: 0.2～1: 0.3 the xylitol and the mixture of starch; Or the ratio of weight is 1: 0.2～1: 0.3 the lactose and the mixture of starch; Or the ratio of weight is that the mixture of 1: 0.2～1: 0.4 xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that pharyngitis is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, has wind and heat dispersing, and the effect of resolving toxin and disinhibiting the throat is used for acute pharyngitis due to wind-heat clinically, pharyngalgia, dry pharynx, thirsty; Or micro evil wind, heating, red swelling of the pharynx, tongue tip side of red, white and thin fur or BOHUANG, floating and rapid pulse or sliding number person are suitable for acute pharyngitis and see above-mentioned patient.Reasonable recipe of the present invention, poisonous side effect of medicine is low, it is bigger to have overcome the side effect of western medicine coronary heart disease, and the Chinese medicine curative effect is low, flavour of a drug are many or the substrate adjuvant has the shortcoming of certain toxic and side effects, is the medicine of the acute and chronic pharyngitis of treatment determined of a kind of economy, material benefit, curative effect.
In order to understand the present invention better, below with test explanation advantages of the present invention such as the dissolve scattered time limit of new substrate QINGYAN DIWAN and the QINGYAN DIWAN made for the substrate adjuvant with the Polyethylene Glycol, drop pill soft durometer, the sticking balls of drop pill.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the QINGYAN DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: the new substrate QINGYAN DIWAN of the present invention (newly) is the QINGYAN DIWAN (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of QINGYAN DIWAN made from the new medium adjuvant of table 1 (newly) with the Polyethylene Glycol be QINGYAN DIWAN (old) dissolve scattered time limit made of adjuvant, weight differential relatively
| 0 month | January | February | March | June | December | ||
| 1 batch | Criterion | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ????2′2″ ????????4′23″ | ????2′6″ ????????4′27″ | ????2′5″ ????????4′22″ | ????2′4″ ????????4′25″ | ??2′3″ ????4′21″ | ????2′2″ ????????4′30″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ????2′2″ ????????4′28″ | ????2′3″ ????????4′24″ | ????2′2″ ????????4′26″ | ????2′5″ ????????4′25″ | ??2′4″ ????4′24″ | ????2′6″ ????????4′26″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ????2′4″ ????????4′22″ | ????2′4″ ????????4′22″ | ????2′3″ ????????4′27″ | ????2′3″ ???????4′28″ | ??2′7″ ????4′29″ | ????2′5″ ????????4′30″ | |
Test data shows, the dissolve scattered time limit of new substrate QINGYAN DIWAN is that the QINGYAN DIWAN made of adjuvant is few with the Polyethylene Glycol; The ball amount difference of the QINGYAN DIWAN that new and old substrate is made all is controlled in the pharmacopeia prescribed limit.The result of the test explanation, the molten diffusing speed of the QINGYAN DIWAN that novel adjuvant is made is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
Test example 2: the present invention with the Polyethylene Glycol be the sticking ball comparative observation of QINGYAN DIWAN soft durometer, drop pill that adjuvant is made
The present invention be that the QINGYAN DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: the new substrate QINGYAN DIWAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the QINGYAN DIWAN (old) that adjuvant is made, commercially available.
2. method and result:
Get three batches of new, old substrate QINGYAN DIWAN, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the QINGYAN DIWAN reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: three batches of QINGYAN DIWAN made from the new medium adjuvant (newly) with the Polyethylene Glycol be QINGYAN DIWAN (old) character observation made of adjuvant relatively
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
Test data shows, new substrate QINGYAN DIWAN soft durometer changes and be that the QINGYAN DIWAN made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of new substrate QINGYAN DIWAN, firmness change and be that the QINGYAN DIWAN made of adjuvant is similar with the Polyethylene Glycol.Presentation of results, the sticking ball of the QINGYAN DIWAN that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g xylitol 10g, starch 2g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 2
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, lactose 11.5g, starch 2g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting lactose and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 3
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10.7g, arabic gum 4.3g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 4
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10g, starch 2.5g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the liquid paraffin; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made 1000 drop pill, promptly.
Embodiment 5
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 12.3g, arabic gum 2.7g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.2～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 6
(a): get Indigo Naturalis 2g, Radix Glycyrrhizae 2g, Fructus Chebulae 2g, Mentholum 3g, Borneolum Syntheticum 0.34g, artificial Calculus Bovis 0.3g, xylitol 8g, erythritol 5g, methylcellulose 1.5g is standby;
(b): get the Fructus Chebulae and add 15 times, 8 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 8 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2～3 hours;
(c): get methylcellulose; erythritol; the xylitol mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum successively; Fructus Chebulae's cream; the artificial Calculus Bovis; Borneolum Syntheticum; Mentholum makes mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is in following system of 60～65 ℃ of temperature; the dropper bore is 1.21～3.5 millimeters and splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Embodiment 7
(a): get Indigo Naturalis 4g, Radix Glycyrrhizae 4g, Fructus Chebulae 2g, Mentholum 2g, Borneolum Syntheticum 0.8g, artificial Calculus Bovis 0.5g, trehalose 8.5g, hydroxypropyl emthylcellulose 1.5g, standby;
(b): get the Fructus Chebulae and add 20 times, 12 times moisture and got indescribably 2 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 10 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2 hours;
(c): get trehalose, hydroxypropyl emthylcellulose mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture is at 45～115 ℃ of heating and meltings; stir; mixing time is 1～120 minute, and insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore and splashes in-20～25 ℃ the vegetable oil; make 1000 drop pill, promptly.
Embodiment 8
(a): get Indigo Naturalis 3g, Radix Glycyrrhizae 3g, Fructus Chebulae 2g, Mentholum 2.8g, Borneolum Syntheticum 0.6g, artificial Calculus Bovis 0.4g, xylitol 18.g, xanthan gum 4.5g are standby;
(b): get the Fructus Chebulae and add 18 times, 9 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 7 times of 90～92% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 2 times 17～19% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 3 hours;
(c): get xylitol and xanthan gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture is at 45～75 ℃ of heating and meltings; stir; mixing time is 1～20 minute, and insulation is 1.30～3.0 millimeters at 55～75 ℃ of temperature following system, dropper bore and splashes in-20～25 ℃ the methyl-silicone oil; make 1000 drop pill, promptly.
Embodiment 9
(a): get Indigo Naturalis 5g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 0.2g, artificial Calculus Bovis 0.7g, xylitol 23.4g, Ficus elastica 3.6g are standby;
(b): get the Fructus Chebulae and add 25 times, 12 times moisture and got indescribably 2.5 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 8 times of 80～90% ethanol, 6 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 4 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get xylitol and starch mix homogeneously; add the refining Indigo Naturalis of above-mentioned processing and fully stir, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 65～85 ℃ of heating and meltings; stir, mixing time is 5～30 minutes, insulation; at 55～75 ℃ of temperature following system, dropper bore is 1.20～3.0 millimeters; splash in 0～5 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 10
(a): get Indigo Naturalis 1g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 1.2g, artificial Calculus Bovis 0.7g, sorbitol 24.9, arabic gum 2.4 is standby;
(b): get the Fructus Chebulae and add 30 times, 15 times moisture and got indescribably 3 hours, 2 hours, filter, merging filtrate is condensed into cream, adds 12 times of 80～99% ethanol, 10 times of precipitate with ethanol 3 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.15; After getting hydrochloric acid that Indigo Naturalis adds 6 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 4 times extracted 4 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.15, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 5 times, volatilizes naturally 6 hours;
(c): get sorbitol and Arabic evenly mixed; add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 75～115 ℃ of heating and meltings; stir, mixing time is 10～20 minutes, insulation; at 75～95 ℃ of temperature following system, dropper bore is 1.15～2.35 millimeters; splash in 5～15 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 11
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10g, starch 2.8g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture stirs at 45～115 ℃ of heating and meltings; mixing time is 1～120 minute; insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in 5～8 the liquid paraffin; make drop pill, promptly.
Embodiment 12
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, lactose 18g, starch 3g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting lactose and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 15 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.11～2.5 millimeters; splash in 0～18 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 13
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 20g, arabic gum 6.5g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 3 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters; splash in 0～10 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 14
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 35g, starch 8g, erythritol 6g is standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): it is evenly mixed to get xylitol, starch and erythritol; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～65 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.21～3.5 millimeters at 60～65 ℃ of temperature following system, dropper bore, splashes in 0～5 ℃ the liquid paraffin, methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made 1000 drop pill, promptly.
Embodiment 15
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 15g, arabic gum 4g, trehalose 3g is standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get xylitol, trehalose and arabic gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 8 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Embodiment 16
(a): get Indigo Naturalis 2g, Radix Glycyrrhizae 2g, Fructus Chebulae 2g, Mentholum 3g, Borneolum Syntheticum 0.34g, artificial Calculus Bovis 0.3g, sorbitol 35g, cyclodextrin 3g, hydroxypropyl emthylcellulose 4g is standby;
(b): get the Fructus Chebulae and add 15 times, 8 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 8 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2～3 hours;
(c): get sorbitol, cyclodextrin, hydroxypropyl methylcellulose mixtures and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 17
(a): get Indigo Naturalis 4g, Radix Glycyrrhizae 4g, Fructus Chebulae 2g, Mentholum 2g, Borneolum Syntheticum 0.8g, artificial Calculus Bovis 0.5g, trehalose 12g, pregelatinized Starch 3g, xanthan gum 3g is standby:
(b): get the Fructus Chebulae and add 20 times, 12 times moisture and got indescribably 2 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 10 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2 hours;
(c): get trehalose, pregelatinized Starch, xanthan gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 18
(a): get Indigo Naturalis 3g, Radix Glycyrrhizae 3g, Fructus Chebulae 2g, Mentholum 2.8g, Borneolum Syntheticum 0.6g, artificial Calculus Bovis 0.4g, sorbitol 7g, xylitol 6g, lactose 3g, chitin 1g are standby;
(b): get the Fructus Chebulae and add 18 times, 9 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 7 times of 90～92% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 2 times 17～19% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 3 hours;
(c): get sorbitol, xylitol, lactose, chitin mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 19
(a): get Indigo Naturalis 5g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 0.2g, artificial Calculus Bovis 0.7g, lactose 22g, carrageenan 4g are standby:
(b): get the Fructus Chebulae and add 25 times, 12 times moisture and got indescribably 2.5 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 8 times of 80～90% ethanol, 6 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 4 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get lactose and carrageenan mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirs; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 65 ℃ of heating and meltings; stir; mixing time is 10～20 minutes; insulation is 1.21～2.5 millimeters at 65 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 20
(a): get Indigo Naturalis 1g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 1.2g, artificial Calculus Bovis 0.7g, xylitol 18g, sesbania gum 4g, standby;
(b): get the Fructus Chebulae and add 30 times, 15 times moisture and got indescribably 3 hours, 2 hours, filter, merging filtrate is condensed into cream, adds 12 times of 80～99% ethanol, 10 times of precipitate with ethanol 3 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.15; After getting hydrochloric acid that Indigo Naturalis adds 6 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 4 times extracted 4 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.15, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 5 times, volatilizes naturally 6 hours;
(c): get an amount of xylitol and sesbania gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～68 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 60～68 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Claims (13)
1, a kind of medicine for the treatment of pharyngitis, it is characterized in that its master is by 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, the medicine of treatment pharyngitis as claimed in claim 1, it is characterized in that it is to be made by 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, the medicine of treatment pharyngitis as claimed in claim 2, it is characterized in that it is to be made by 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, as the medicine of claim 1,2 or 3 described treatment pharyngitis, it is characterized in that it can also contain chemosynthesis adjuvant and animal origin adjuvant in above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
5, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
7, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
8,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
9,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
10,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
11, the preparation method of claim 1,2 or 3 described treatment pharyngitis medicines is characterized in that this method comprises the steps:
(a): it is standby to get 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 10～30 times, 5～15 times moisture and got indescribably 0.5～3 hour, 0.5～2 hour, filter, merging filtrate is condensed into cream, add 4～12 times of 80～99% ethanol, 2～10 times of precipitate with ethanol 1～3 time, get supernatant and reclaim ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 2～6 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 2～4 times extracted 1～4 hour at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stir; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture stirs at 45～115 ℃ of heating and meltings; mixing time is 1～120 minute; insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil; make drop pill, promptly.
12, the preparation method of treatment pharyngitis medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a): it is standby to get 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 15～25 times, 8～12 times moisture and got indescribably 1～2 hour, 0.75～1.5 hour, filter, merging filtrate is condensed into cream, add 6～10 times of 90～97% ethanol, 4～6 times of precipitate with ethanol 2 times, get supernatant and reclaim ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 3～5 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 1.5～3.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 1.5～3.5 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters; splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
13, the preparation method of treatment pharyngitis medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir, mixing time is 10～30 minutes, insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
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| CN1899420B (en) * | 2006-06-30 | 2010-05-12 | 董继湘 | Medicine for treating pharyngitis and its preparing method |
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| CN1331495C (en) * | 2005-09-27 | 2007-08-15 | 广西博科药业有限公司 | Throat-clearing lozenge |
| CN1899420B (en) * | 2006-06-30 | 2010-05-12 | 董继湘 | Medicine for treating pharyngitis and its preparing method |
| CN101194922B (en) * | 2006-12-08 | 2013-04-17 | 天士力制药集团股份有限公司 | Acesodyne medicament dropping pills and method for preparing the same |
| CN101088517B (en) * | 2007-04-29 | 2010-05-19 | 黄规律 | Process of making sweel cool health myrobalan fruit |
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| CN102485242A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof |
| CN102485242B (en) * | 2010-12-03 | 2013-11-20 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof |
| CN102485241B (en) * | 2010-12-03 | 2013-12-25 | 天津中新药业集团股份有限公司第六中药厂 | Traditional Chinese medicine composition having functions of dispelling wind, clearing heat, removing toxins and benefiting throat and preparation method thereof |
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