CN1593451A - Externally applied medicine for promoting male erection - Google Patents
Externally applied medicine for promoting male erection Download PDFInfo
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- CN1593451A CN1593451A CN 03159047 CN03159047A CN1593451A CN 1593451 A CN1593451 A CN 1593451A CN 03159047 CN03159047 CN 03159047 CN 03159047 A CN03159047 A CN 03159047A CN 1593451 A CN1593451 A CN 1593451A
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- adenosine cyclophosphate
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Abstract
The invention provides an externally applied medicine for promoting male erection, wherein the medicine mainly comprises cyclicamp or its medicinal derivative, embellishing articles, absorbent prepared from medicinal findings, and Phentolamine Mesylate, papaverin hydrochloride, theobromine, sodium nitroprusside can be used as synergy agent.
Description
Technical field the invention belongs to medical technical field, relates to a kind of external used medicine that can promote male penis erection.
Background technology male penis erection dysfunction (ED) is the common and multiple disease of middle-aging male, method to the erection problem treatment is a lot, oral medicine such as sldenafil (being commonly called as " viagra ") are arranged clinically, this medicine curative effect aspect treatment ED is better, but owing to be oral administration, the side effect reaction incidence rate of general is also higher, and onset is slower, need take in one hour in the sexual intercourse precontract, price is also very expensive; Another kind of Therapeutic Method is to patient's penis cavernosa injection vasodilation example hydrochloric acid papaverine, phentolamine and prostaglandin E
1To reach quick erection, though this Therapeutic Method effect is better, can causes pain, wound and be inconvenient to use to user, also may produce serious consequences such as infection, priapism and spongy body pathological changes; Also has prostaglandin E in addition by the urethra administration
1The external ointment is to restrain medicine made in U.S.A (middle mountain) company limited production by the Buddhist nun, trade name " BEFAR ", and this medicine is with prostaglandin E
1Make the emulsifiable paste shape, absorb and promote erection fast by the urethra administration, the drug use of this external is convenient, rapid-action, safety and side effect are gently little, and its shortcoming is a prostaglandin E
1Preserve at normal temperatures and can reduce drug effect, need medicine is stored in the refrigerator, preserve very inconvenient and cost an arm and a leg, limited its scope of application.
Summary of the invention the purpose of this invention is to provide a kind of externally applied transdermal that passes through safe, efficient, that preservation is convenient, moderate and absorbs the medicine that promotes erection.
For reach above-mentioned from, the present invention adopts and to adopt certain pharmaceutic adjuvant to make the cutaneous permeable agent of external adenosine cyclophosphate or its pharmaceutically useful derivant, trim, absorbs by positions such as urethra, glans penis, prepuce of penis to enter penis and reach the effect that promotes erection.
Adenosine cyclophosphate (cyclic Adenosine Monophosphate; abbreviation cAMP) claims cyclic adenosine monophosphate (cAMP) again; it is a kind of arteriectasia agent; the pharmaceutically acceptable derivant that adenosine cyclophosphate is commonly used has meglumine adenosine cycle phosphate, dibutyryl adenosine cyclophosphate etc., is usually used in the auxiliary treatment of angina pectoris and myocardial infarction clinically.The present invention adopts adenosine cyclophosphate class medicine to promote the mechanism of erecing to be as expansion penis blood vessel: adenosine cyclophosphate class medicine is after Transdermal absorption enters body of penis, make the smooth muscle relaxation of cavernous body of penis and tremulous pulse thereof, increase the penile blood flow amount and make penis hyperemia, this effect causes that simultaneously the penis angular vein is oppressed, cause the expansion of spongy body lacuna, blood remains in a standstill, thereby promotes erection and strong.
The medicine that externally applied transdermal of the present invention absorbs, its dosage form are easy to use and smear the liquid or the body of paste of absorption, comprise dosage forms such as the various water liquid of acceptable, emulsion, emulsifiable paste, gel, cream frost on the medicine.
Owing to be the pharmaceutical dosage form that externally applied transdermal absorbs, in order to guarantee the convenient use of medicament and absorbing of medicine, the present invention is except Main Ingredients and Appearance adenosine cyclophosphate or its pharmaceutically useful derivant, trim, at least also comprise in following several composition one or more, they are that excipient, Percutaneous absorption enhancer, stabilizing agent, pH value are regulated buffer agent, medicine synergetic effect additive.
Excipient is the carrier of medicine Main Ingredients and Appearance, it is the carrier material that is used for disperseing Main Ingredients and Appearance and keeps drug form, the present invention is owing to be the cutaneous permeable agent of external, but the excipient of all cutaneous permeable agents of acceptable on the drug of choice thing is for example selected one or more combinations in water, ethanol, propylene glycol, glycerol, carbomer, cellulose, gelatin, sodium polyacrylate, polyvinyl alcohol, stearic acid, tristerin, liquid paraffin, the vaseline etc. for use;
Percutaneous absorption enhancer is to promote the medicine Main Ingredients and Appearance to see through the material of skin and mucosa absorption fast, but all Percutaneous absorption enhancers of acceptable on the present invention's drug of choice thing for example select for use one or more rents in ethanol, propylene glycol, azone, ethyl oleate, oleic acid, N-methyl-ketopyrrolidine, alpha-pyrrolidone, isopropyl myristate, Borneolum Syntheticum, Mentholum, dodecyl sodium sulfate, Polyethylene Glycol, Polysorbate, the Span to close;
Stabilizing agent is to guarantee medicine stable existence, material of never degenerating, not consuming in storage life and use, can select one or more combinations in pharmaceutical preservative, the edetate for use;
It is to regulate medicine pH value scope so that medicine is preserved stingless excitation when contacting skin that pH value is regulated buffer agent, but acceptable acid on the present invention's drug of choice thing, alkali, salt are regulated buffer agent as pH value, for example can select one or more combinations in hydrochloric acid, sodium hydroxide, citrate, the phosphate for use;
The medicine synergetic effect additive is that adenosine cyclophosphate or derivatives thereof, trim are had the synergistic material of potentiation, the present invention select for use in phentolamine mesylate, papaverin hydrochloride, pentoxifylline, the sodium nitroprusside one or more the combination as the medicine synergetic effect additive.
The present invention selects appropriate pharmaceutic adjuvant for use, adenosine cyclophosphate or its pharmaceutically acceptable derivant, trim are made the cutaneous permeable agent of external, only an amount of medicament need be splashed into urethra during use or be applied on the glans penis spongy body, absorb by positions such as urethra, glans penis, prepuce of penis, reach the congested purpose of erecing of quick promotion penis, have easy to use, safe efficient, be easy to preserve the also suitable popularity consumption of price.
Specific embodiment embodiment 1: get adenosine cyclophosphate 3 grams, and propylene glycol 5 grams, azone 3 grams, dodecyl sodium sulfate 1.5 grams, distilled water and phosphate buffer are an amount of.
Preparation method: with 1.5 gram dodecyl sodium sulfates and 70 gram distilled water Hybrid Heating dissolvings, again 5 gram propylene glycol, 3 gram azones and 3 gram adenosine cyclophosphate are added mix homogeneously successively, the reuse phosphate buffer is regulated the pH value of mixed solution between 6～8, last adding distil water to 100 milliliter, mixing, the degassing, sterilization packaging get final product.Only need during use medicinal liquid to be splashed into 1～2, get final product by the urethra absorption from urethral orifice.
Embodiment 2: get meglumine adenosine cycle phosphate 6 grams, and phentolamine mesylate 2.3 grams, carbomer-940 0.8 gram, ethanol 6 grams, glycerol 5 grams, Tween-80 0.2 gram, ethyl hydroxybenzoate 0.1 gram, sodium hydrate aqueous solution and distilled water are an amount of.
Preparation method: 0.8 carbomer-940 and 0.2 gram Tween-80 are mixed with 30 ml distilled waters, an amount of sodium hydrate aqueous solution is added upward liquid, stir, again 0.1 gram ethyl hydroxybenzoate is dissolved in adding gradually behind the ethanol and stirs evenly, liquid to be mixed adds stirring and evenly mixing successively with 6 gram meglumine adenosine cycle phosphates and the appropriate Lamine of 2.3 gram methanesulfonic acid acid after stirring and being transparence, regulates pH value after 6～8, adds to 100 milliliters with distilled water, abundant mixing, the degassing, sterilization packing promptly get gelationus agent.Take a morsel during use and be applied in glans penis and the prepuce of penis place gets final product.
Claims (10)
1. promote the external used medicine of male penis erection, the Main Ingredients and Appearance that it is characterized in that medicine is adenosine cyclophosphate or its pharmaceutically useful derivant, trim.
2. external used medicine according to claim 1, it is characterized in that in the medicine except adenosine cyclophosphate or its pharmaceutically useful derivant, trim, comprise that also excipient, Percutaneous absorption enhancer, stabilizing agent, pH value regulate one or more in buffer agent, the medicine synergetic effect additive.
3. according to claim 1 and 2 described external used medicines, it is characterized in that pharmaceutical dosage form is water liquid, emulsion, emulsifiable paste, gel or cream cream.
4. according to claim 1,2 and 3 described external used medicines, it is characterized in that medicine absorbs by phallic urethra, glans penis, prepuce of penis position.
5. external used medicine according to claim 2, it is characterized in that excipient is the carrier material that is used for disperseing Main Ingredients and Appearance and keeps drug form, but the excipient of all cutaneous permeable agents of acceptable on the drug of choice thing, one or more combinations in preferred water, ethanol, propylene glycol, glycerol, carbomer, cellulose, gelatin, sodium polyacrylate, polyvinyl alcohol, stearic acid, tristerin, liquid paraffin, the vaseline.
6. external used medicine according to claim 2, it is characterized in that Percutaneous absorption enhancer is to promote the medicine Main Ingredients and Appearance to see through the material of skin and mucosa absorption fast, but all Percutaneous absorption enhancers of acceptable on the drug of choice thing, one or more combinations in preferred alcohol, propylene glycol, azone, ethyl oleate, oleic acid, N-methyl-ketopyrrolidine, alpha-pyrrolidone, isopropyl myristate, Borneolum Syntheticum, Mentholum, dodecyl sodium sulfate, Polyethylene Glycol, Polysorbate, the Span.
7. external used medicine according to claim 2 is characterized in that stabilizing agent is to guarantee medicine stable existence, material of never degenerating, not consuming in storage life and use, can select one or more combinations in pharmaceutical preservative, the edetate for use.
8. external used medicine according to claim 2, it is characterized in that it is to regulate medicine pH value scope so that medicine is preserved the material of stingless excitation when contacting skin that pH value is regulated buffer agent, select for use on the medicine acceptable acid, alkali, salt to regulate buffer agent, preferably use one or more combinations in hydrochloric acid, sodium hydroxide, citrate, the phosphate as pH value.
9. external used medicine according to claim 2, it is characterized in that the medicine synergetic effect additive is that adenosine cyclophosphate or derivatives thereof, trim are had the synergistic material of potentiation, select for use in phentolamine mesylate, papaverin hydrochloride, pentoxifylline, the sodium nitroprusside one or more the combination as the medicine synergetic effect additive.
10. according to claim 1,2,3,4,5,6,7 or 8 described external used medicines, it is characterized in that the preferred meglumine adenosine cycle phosphate of pharmaceutically acceptable derivant, trim and the dibutyryl adenosine cyclophosphate of adenosine cyclophosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03159047 CN1593451A (en) | 2003-09-12 | 2003-09-12 | Externally applied medicine for promoting male erection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03159047 CN1593451A (en) | 2003-09-12 | 2003-09-12 | Externally applied medicine for promoting male erection |
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| Publication Number | Publication Date |
|---|---|
| CN1593451A true CN1593451A (en) | 2005-03-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03159047 Pending CN1593451A (en) | 2003-09-12 | 2003-09-12 | Externally applied medicine for promoting male erection |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011058374A1 (en) * | 2009-11-13 | 2011-05-19 | Biocopea Limited | Drug combination with theobromine and its use in therapy |
| US8703158B2 (en) | 2009-06-16 | 2014-04-22 | Biocopea Limited | Theobromine for the treatment of cough |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| CN106110409A (en) * | 2016-08-29 | 2016-11-16 | 桂林恒保健康用品有限公司 | Extend the condom of sex time |
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
-
2003
- 2003-09-12 CN CN 03159047 patent/CN1593451A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703158B2 (en) | 2009-06-16 | 2014-04-22 | Biocopea Limited | Theobromine for the treatment of cough |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9675618B2 (en) | 2009-06-16 | 2017-06-13 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9700561B2 (en) | 2009-06-16 | 2017-07-11 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| WO2011058374A1 (en) * | 2009-11-13 | 2011-05-19 | Biocopea Limited | Drug combination with theobromine and its use in therapy |
| CN106110409A (en) * | 2016-08-29 | 2016-11-16 | 桂林恒保健康用品有限公司 | Extend the condom of sex time |
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