CN1568895A - Method for detecting blood oxygenation of mammary tissue - Google Patents

Abstract

The present invention relates to a method for detecting blood oxygenation of mammary tissue, which includes the following steps: transmitting a galactophore to be detected by visible-near infrared light having continuous wavelength, the transmitted light passes through an optical filter having a wavelength about Lambda 1 and Lambda 2 for filtering and then passes through each CCD camera to image on the CCD plane; the image data is transmitted by the analog video output terminal of each CCD camera through video lines to the input terminal of an image acquisition card having two video input terminals, and then is processed by mode number conversion to obtain two detected digital mammary images of the galactophore. Two digital mammary images of reference side galactophore also can be obtained by above method. The four images can be conversed to obtain a blood content image and an oxygen content image. The invention images the blood oxygenation function of mammary tissue by above method, can obtain the distribution status of the blood oxygenation function of mammary tissue, and thereby can provides effective basis for diagnosing galactophore pathological changes, pathological changes position and treatment based on the distribution status of the blood oxygenation function of mammary tissue.

Description

Method for detecting blood oxygenation of mammary tissue

Technical field

The present invention relates to a kind of method for detecting blood oxygenation of mammary tissue, especially the optical means noinvasive with physics detects mammary tissue blood, oxygen content.

Background technology

The pathological changes of human body mammary gland and its blood, oxygen content change closely related, thereby mammary gland blood-oxygen content and delta data (index) are the important evidence of diagnosis and treatment mastopathy.Blood oxygen detection method of the prior art is used for mammary gland blood-oxygen and detects, only can obtain local organization (often certain a bit) oxygen content (being equipped with substantial connection) with detecting position, but can not obtain the distribution of mammary tissue blood oxygen, being difficult to provides effective foundation to diagnosis breast lesion, pathological changes location and treatment.

Summary of the invention

The objective of the invention is to provide a kind of mammary tissue blood oxygen noinvasive detection method, this method can obtain the distribution of mammary tissue blood oxygen by the mammary tissue blood oxygen function imaging, and then provides effective foundation by the distribution situation of mammary tissue blood oxygen for diagnosis breast lesion, pathological changes location and treatment.

Because the white (HbO of Oxygenated blood red eggs ₂) with deoxyhemoglobin (Hb) to as seen-light near infrared spectrum zone 600nm-800nm and two wavelength band of 810nm-1000nm has different light absorption characteristics, according to this specific character and on the basis of corresponding living model, the present invention proposes following technical proposals: method for detecting blood oxygenation of mammary tissue may further comprise the steps:

One. with visible-near infrared light (500nm-1500nm) of continuous wavelength to tested side mammary gland (referring to a doubtful ill mammary gland in two mammary gland of human body) transmission, its transillumination is that the optical filter of λ 1=600nm-800nm, λ 2=810nm-1000nm filters through wavelength respectively, and the photographic head by separately is imaged on the CCD plane respectively then; Then, be sent to the input of image pick-up card respectively through video line,, obtain two width of cloth digitized galactophore images of tested side mammary gland again by analog-to-digital conversion with two video inputs mouths by the analog video output port of separately photographic head.

Two. set by step 1) with visible-near infrared light (500nm-1500nm) of continuous wavelength to reference side mammary gland (referring in two mammary gland of human body another mammary gland) transmission with respect to tested side mammary gland, obtain two width of cloth digitized galactophore images with reference to side mammary gland.

Three. set by step 1), 2) the tested side that obtains and with reference to side mammary gland totally four width of cloth images contain spirogram and oxygen content figure through the blood that computing formula (1) (2) obtain tested side mammary gland respectively.

Blood content: $I_b(x,y)=\log \frac{H_1(x,y)+H_2(x,y)}{J_1(x,y)+J_2(x,y)}----\left(1\right)$

Oxygen content: $I_o(x,y)=\frac{H_1(x,y)+J_2(x,y)}{H_2(x,y)+J_1(x,y)}----\left(2\right)$

I in the formula _b(x, y) the tested side mammary gland blood of expression contains (x, the blood content of y) locating on the spirogram;

I _o(x, y) (x, the oxygen content of y) locating on the tested side mammary gland oxygen content figure of expression;

H ₁(x, y) expression visible-tested side mammary gland of transmission of near infra red light and be behind the optical filter of λ 1 by wavelength corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image;

H ₂(x, y) expression visible-tested side mammary gland of transmission of near infra red light and be behind the optical filter of λ 2 by wavelength corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image;

J ₁(x, y) expression visible-transmission of near infra red light is corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image with reference to side mammary gland and by wavelength behind the optical filter of λ 1;

J ₂(x, y) expression visible-transmission of near infra red light is right behind the optical filter of λ 2 with reference to side mammary gland and by wavelength

Should (x y) locates the light intensity that CCD detects on the infrared scan image.

The present invention to the mammary tissue blood oxygen function imaging, can obtain the distribution of mammary tissue blood oxygen by said method, and then provides effective foundation by the distribution situation of mammary tissue blood oxygen for diagnosis breast lesion, pathological changes location and treatment.

Description of drawings

Fig. 1 is a method for detecting blood oxygenation of mammary tissue sketch map of the present invention;

Fig. 2 is the infrared scan figure behind the optical filter of λ 1 through wavelength for tested side mammary gland in the application example of the present invention;

Fig. 3 is the infrared scan figure behind the optical filter of λ 2 through wavelength for tested side mammary gland in the application example of the present invention;

Fig. 4 is for being infrared scan figure behind the optical filter of λ 1 through wavelength with reference to side mammary gland in the application example of the present invention;

Fig. 5 is for being infrared scan figure behind the optical filter of λ 2 through wavelength with reference to side mammary gland in the application example of the present invention;

Fig. 6 contains spirogram for the blood that obtains in the application example of the present invention;

The oxygen content figure of Fig. 7 for obtaining in the application example of the present invention.

The specific embodiment

Referring to Fig. 1, to the 500nm-1500nm of tested side mammary gland 2 usefulness continuous wavelengths visible-near infrared light 1 transmission, since mammary gland tissue to by wherein as seen-near infrared spectrum presents different absorption characteristics, for 1 R (x on the tested side mammary gland, y), wherein transillumination is the optical filter 3,7 of λ 1, λ 2 through wavelength respectively continuously, satisfies the white (HbO of Oxygenated blood red eggs ₂) and the wavelength at deoxyhemoglobin (Hb) absworption peak place pass through; Then respectively by photographic head 4,8 be imaged on separately on the CCD5 plane (x, y) locate with the CCD9 plane on (x y) locates, and has guaranteed to be imaged on same position for the same point on the mammary gland tissue on two CCD.Then, two groups of analogue signals are sent to AV1 mouth 11, the AV2 mouth 12 of video frequency collection card respectively via video-out port Video Out6, Video Out10, by analog-to-digital conversion, obtain two width of cloth digitized galactophore image H again ₁(x, y), H ₂(x, y).For reference side mammary gland, equally also can obtain two width of cloth digitized galactophore image J as stated above ₁(x, y), J ₂(x, y).Four width of cloth image H ₁(x, y), H ₂(x, y), J ₁(x, y), J ₂(x y) calculates blood content Figure 13 and oxygen content Figure 14 through computing formula (1) (2).

Above-mentioned image pick-up card is to convert light intensity to digital quantity from analog quantity, promptly the gray value in the infrared scan breast image corresponding to continuous light transmission mammary gland after the light intensity that detects of detector.Contain among spirogram and the oxygen content figure at blood, passing through computing formula (1) (2) respectively, to obtain blood content value and oxygen content value be that method with pseudo-colours shows, be about to blood content value and oxygen content value and be divided into several (as 256) interval values according to certain rule, each interval value is corresponding to a kind of different color (as 256 different colors), and the result is: the Two dimensional Distribution of blood content and oxygen content is that the mode with pseudo-colours shows---promptly obtain the function image of blood content and oxygen content.By the function image of corresponding blood content and oxygen content, can obtain the blood content and the oxygen content of tested side mammary gland any point easily, the doctor can provide foundation for the judgement mastopathy according to the value of blood content and oxygen content.

Application example:

There is a patient to doubt and is breast carcinoma, by the present invention gather tested side, with reference to behind the side galactophore image (seeing Fig. 2,3,4,5), obtain blood through processing and contain spirogram (see figure 6) and oxygen content figure (see figure 7), check that from Fig. 6,7 the average blood content value in mammary gland Suspected Area is-0.74777, the averaged oxygen content value is 0.575174, meet " high blood hypoxia " feature, thereby be diagnosed as breast carcinoma.

Claims (1)

1. method for detecting blood oxygenation of mammary tissue may further comprise the steps:

1) visible-near-infrared with the 500nm-1500nm of continuous wavelength to the transmission of tested side mammary gland, its transillumination is that the optical filter of λ 1=600nm-800nm, λ 2=810nm-1000nm filters through wavelength respectively, and the photographic head by separately is imaged on the CCD plane respectively then; Then, be sent to the input of image pick-up card respectively through video line,, obtain two width of cloth digitized galactophore images of tested side mammary gland again by analog-to-digital conversion with two video inputs mouths by the analog video output port of separately photographic head;

2) set by step 1) visible-near-infrared to the transmission of reference side mammary gland with the 500nm-1500nm of continuous wavelength, obtain two width of cloth digitized galactophore images with reference to side mammary gland;

3) set by step 1), 2) the tested side that obtains and with reference to side mammary gland totally four width of cloth images contain spirogram and oxygen content figure through the blood that computing formula (1) (2) obtain tested side mammary gland respectively;

Blood content: $I_b(x,y)=\log \frac{H_1(x,y)+H_2(x,y)}{J_1(x,y)+J_2(x,y)}---\left(1\right)$

Oxygen content: $I_o(x,y)=\frac{H_1(x,y)\×J_2(x,y)}{H_2(x,y)\×J_1(x,y)}---\left(2\right)$

I in the formula _b(x, y) the tested side mammary gland blood of expression contains (x, the blood content value of y) locating on the spirogram;

I _o(x, y) (x, the oxygen content value of y) locating on the tested side mammary gland oxygen content figure of expression;

H ₁(x, y) the expression tested side mammary gland of visible-near-infrared transmission and be behind the optical filter of λ 1 by wavelength corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image;

H ₂(x, y) the expression tested side mammary gland of visible-near-infrared transmission and be behind the optical filter of λ 2 by wavelength corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image;

J ₁(x, y) the visible-near-infrared transmission of expression is corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image with reference to side mammary gland and by wavelength behind the optical filter of λ 1;

J ₂(x, y) the visible-near-infrared transmission of expression is corresponding to (x y) locates the light intensity that CCD detects on the infrared scan image with reference to side mammary gland and by wavelength behind the optical filter of λ 2.

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