CN1562075A - Use of biological active glass to treat gingivits, cyttarrhagia and odontoseisis syndrom - Google Patents
Use of biological active glass to treat gingivits, cyttarrhagia and odontoseisis syndrom Download PDFInfo
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- CN1562075A CN1562075A CN 200410012897 CN200410012897A CN1562075A CN 1562075 A CN1562075 A CN 1562075A CN 200410012897 CN200410012897 CN 200410012897 CN 200410012897 A CN200410012897 A CN 200410012897A CN 1562075 A CN1562075 A CN 1562075A
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- odontoseisis
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- 239000011521 glass Substances 0.000 title claims description 34
- 208000011580 syndromic disease Diseases 0.000 title 1
- 239000005313 bioactive glass Substances 0.000 claims abstract description 18
- 208000007565 gingivitis Diseases 0.000 claims abstract description 17
- 208000032843 Hemorrhage Diseases 0.000 claims abstract description 16
- 229940034610 toothpaste Drugs 0.000 claims abstract description 13
- 239000000606 toothpaste Substances 0.000 claims abstract description 13
- 230000000694 effects Effects 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 15
- 239000008187 granular material Substances 0.000 claims description 8
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 230000004071 biological effect Effects 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 2
- 229910011255 B2O3 Inorganic materials 0.000 abstract 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 abstract 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 abstract 1
- 229910052681 coesite Inorganic materials 0.000 abstract 1
- 229910052906 cristobalite Inorganic materials 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 229910052682 stishovite Inorganic materials 0.000 abstract 1
- 229910052905 tridymite Inorganic materials 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 11
- 206010018276 Gingival bleeding Diseases 0.000 description 10
- 208000024283 Gingival haemorrhages Diseases 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 10
- 210000000988 bone and bone Anatomy 0.000 description 9
- 210000004872 soft tissue Anatomy 0.000 description 9
- 206010052428 Wound Diseases 0.000 description 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 7
- 102000013275 Somatomedins Human genes 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000008467 tissue growth Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000006557 surface reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000005239 tubule Anatomy 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 239000003462 bioceramic Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 235000021059 hard food Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 206010018275 Gingival atrophy Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 239000005312 bioglass Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000854 inhibitional effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000009418 renovation Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Cosmetics (AREA)
- Glass Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An application of the bioactive glass for preparing toothpaste or solution for treating gingivitis, dental hemorrhage and odontoseisis is disclosed. Said bioactive glass is prepared from SiO2, CaO, Na2O, P2O5 and B2O3.
Description
Technical field the present invention relates to bioactive glass treatment gingivitis, dental hemorrhage and removes the odontoseisis studies on some in dications of.
The background technology bioactivity glass is clinically as oral cavity bone renovating material, orthopaedics the bone impairment renovation material applicating history in existing more than 15 year in worldwide.One of bioactivity glass characteristic is when bioactive glass particle contacts with liquid phase, and the accelerated surface reaction takes place, and its result is: 1, ion discharges; 2, calcium, phosphorus plasma deposition generate support shape hydroxyapatite layer, i.e. a bone mineralising phase on the bioactive glass particle surface.Recently new studies show that, the characteristic of inducing the bone mineralising to form mutually of bioactivity glass can be induced the overglaze formation of new tooth on dental surface, thereby reach the position that is corroded of sealing dentinal tubule, remedying tooth, reach desensitization and prevent the effect of tooth (reference paper 1) in solitude.New research shows that simultaneously bioactivity glass has stronger bactericidal action in liquid environment, particularly oral cavity bacterium is had bactericidal action (reference paper 2).
" bioactive glass compositions and the Therapeutic Method that uses bioactivity glass " (patent No. 97193085), bioactivity glass is by 40-60%SiO
2, 10-30%CaO, 10-35%Na
2O, 2-8%P
2O
5, 0-10%B
2O
3, 0-8%K
2O, 0-5%MgO become through high temperature melting, and it is to the therapeutical effect of dentin hypersensitiveness.Its mechanism is that bioactivity glass can induce the bone mineralising to form mutually, can induce the overglaze formation of new tooth on dental surface, thereby reaches sealing dentinal tubule, remedy the position that is corroded of tooth, reaches desensitization and prevents the effect of tooth in solitude.
Current research shows that bioactivity glass can promote the damaged healing of growth, the bone of osseous tissue can promote the material of the synthetic that the growth of soft tissue is healed again.The surface activity of bioactivity glass can promote the generation of somatomedin, procreation, the activating cell gene expression (reference paper 3,4) of promotion cell.Like this, bioactivity glass begins direct control with the gene of process by directly cell cycle being brought out in those adjustings, to strengthen and to reach tissue is generated and the facilitation of growth.These good characteristics of bioactivity glass derive from its surface activity.
Bioactivity glass uses in the clinical practice of treatment epidermis soft tissue wound healing.Clinical showing, bioactivity glass is promoting that wound healing comprises that oral ulcer, decubital ulcer, long-term rotten to the corn wound, fat liquor voltinism wound, minor burn etc. have presented good result (reference paper 6).
Gingivitis, dental hemorrhage and odontoseisis are than common dental, have than dentin hypersensitiveness and suffer from the patient widely.Oral cavity bacterium is the main cause that causes gingivitis, and the bacterial plaque that gingivitis causes and calculus can be destroyed being connected of dentale tissue and dentale and soft tissue, damage occurs and easily cause dental hemorrhage, and then develop into gingival atrophy, cause odontoseisis, come off.
Now also not useful organisms activity glass treatment gingivitis, dental hemorrhage and the report of removing the odontoseisis symptom.
Summary of the invention the objective of the invention is at above-mentioned present situation, aim to provide reason and example, with the effect of proof bioactive glass treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom with bioactive glass treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom.
Bioactive glass treatment gingivitis, dental hemorrhage and the effect of removing the odontoseisis symptom, bioactivity glass is by SiO
2, CaO, Na
2O, P
2O
5, becoming through high temperature melting, the proportioning of each composition is:
SiO
2?????40-60％?????????CaO????????10-30％
Na
2O?????10-35％?????????P
2O
5?????2-8％
B
2O
3????0-10％??????????K
2O???????0-8％
MgO????????0-5％
Granule is less than biological activity and the biocompatible glass granule of 90 μ m, and with the granule of granule less than the Remineralization effective dose of 10 μ m, the bioactivity glass that becomes through high temperature melting has effect to treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom.
Bioactivity glass can promote the generation of soft tissue cells somatomedin, for the healing of wound provides the endogenous cell somatomedin.Bioactivity glass has inhibition and bactericidal action to oral cavity bacterium, and osseous tissue and soft tissue growth are had promotion and wound healing effect, judges that thus bioactivity glass has effect to treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom.Use has the toothpaste of bioactivity glass and the commodity toothpaste on the market to contrast, and uses the toothpaste that bioactivity glass is arranged, and the gingival hemorrhage index obviously reduces.The odontoseisis patient, after with toothpaste, the odontoseisis symptom is obviously improved, and can bait hard food such as beef.
Specific embodiment bioactivity glass of the present invention is by SiO
2, CaO, Na
2O, P
2O
5, B
2O
3, K
2O, MgO configuration forms.Bioactivity glass can toothpaste or solution form, the effect that reaches treatment gingivitis, dental hemorrhage and remove the odontoseisis symptom in the mode of brushing teeth and gargling.
Bioactivity glass can promote the generation of soft tissue cells somatomedin, for the healing of wound provides the endogenous cell somatomedin.As detailed mechanism, the applicant thinks that bioactivity glass reaches wound healing by the reaction of its surface activity.When bioactive glass particle when wound or soft group of injury region contact with the wound sepage, the accelerated surface reaction takes place, its result is: 1, ion discharges; 2, calcium, phosphorus plasma deposition generate a support shape hydroxyapatite layer on the bioactive glass particle surface; 3, to adsorb into fine microcell be other soft tissue growth cell and some protein growth factors to the high specific surface area of bioactive glass particle, these cells are subjected to the effect of the stable and somatomedin of hydroxyapatite shelf layer, this environment helps the generation of the new tissue of cell, makes the bioactive glass particle surface become the bedding of a connective tissue and mucosal tissue growth; 4, bioactive glass particle surface reaction and ion discharge and improve wound or soft group of injury region pH value, (reference paper 5) suppresses to infect, simultaneously, the ion of release can promote the generation of somatomedin, the growth that promotes soft tissue cells, the gene expression of activating cell.All these effects have reached the effect that promotes wound and soft tissue injury healing.
The present invention, is used for treating gingivitis, dental hemorrhage and removes the odontoseisis symptom to the inhibition of oral cavity bacterium and bactericidal action and to the promotion and the wound healing effect of osseous tissue and soft tissue growth according to bioactivity glass.
* * do with commodity toothpaste on quick toothpaste of the Novartis of toothpaste form and use one market clinical research contrast experiment of anti-gingival hemorrhage with bioactivity glass, experimental group 47 people, matched group 48 people, 34.5 years old mean age, standard deviation: experimental group 8.8 years old, matched group 10.1 years old.
All finish the experimenter (95 people) of test after gingival hemorrhage is estimated, mean that the gingival hemorrhage index is kept the score and standard deviation (SD).Experimental group and matched group gingival hemorrhage index there was no significant difference before the experiment.After six weeks, test group gingival hemorrhage index obviously reduces.After six weeks, test group gingival hemorrhage index is reduced to 58.8%, and matched group gingival hemorrhage index is less than 10%.The concrete contrast situation that gingival hemorrhage index (standard deviation) is kept the score sees the following form;
| Gingival hemorrhage index: mean (standard deviation) | ||
| Experimental group | Matched group | |
| ????n＝47 | ????n＝48 | |
| Baseline ( *) | ????1.14(0.79) | ????1.18(0.71) |
| 6 weeks ( *) | ????0.47(0.36) | ????1.02(0.56) |
| Difference in means baseline-6 week | ????0.67(0.67) ????p＜0.001 | ????0.16(0.69) ????p＞0.05 |
* * done to remove the case test of odontoseisis with the Novartis of toothpaste form quick toothpaste with bioactivity glass, concrete condition is as follows:
The season * *, the man, in year surplus odontoseisis history reaches ten, the state of an illness has developed into and can only make a living to eat liquid food.Diagnosis is three grades of odontoseisiss of dental pattern, and advises its exodontia.Using the quick toothpaste of Novartis after 10 days, the season * * the odontoseisis symptom obviously improves, and can bait hard food such as beef.Through the doctor check its left side tooth odontoseisis symptom basic solution remove, the right side tooth is that slight one-level is loosening.
Reference paper
1.“OCCLUSION?OF?DENTIN?TUBULES?BY?45S5?BIOGLASS
，”LITKOWSKI，HACK，SHEAFFER?AND?GREENSPAN，BIOCERAMICS?Vol.10，411-414，1997
2.P.Stoor，E.Sderling?and?J.I.Salonen，“Antibacterial?effects?of?a?bioactive?glass?paste?on?oralmicroorganisms，”AGTA?Odontol.Scand.56，161-165，1998
3.I.D.Xynos，A.J.Edgar，L.D.K.Buttery，L.L.Hench，J.M.Polak，“Gene-expression?profiling?ofhuman?osteoblasts?following?treatment?with?the?ionic?products?of?Bioglass?45S5?dissolution，”J.Biomed.Mater.Res.，55：151-157，2001
4.L.L.Hench, I.D.Xynos, A.J.Edgar, L.D.K.Buttery, J.M.Polak, Zhong Jipin, Liu Xuanyong, Chang Jiang, " glass of activated gene, " Journal of Inorganic Materials, the 17th volume, the 5th phase, 897-909,2002
5.D.C.Greenspan，J.P.Zhong，G.P.LaTorre“The?Evaluation?of?Surface?Structure?of?BioactiveGlasses?In?Vitro，”Bioceramics?7，1994
6. Cai Duan, Liao Zhenjiang, Fan Yuezu, Zhang Shenghua etc., " skin is given birth to clinical efficacy investigation report-skin and given birth to DermGlas clinical practice data " Huashan Hospital Attached to Medical Collage of Fudan Univ., attached Yueyang hospital of Shanghai Univ. of Traditional Chinese Medicine, the attached sweet spring water of Tongji University's medical college hospital, in August, 2000.
Claims (2)
1, the effect of bioactive glass treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom, bioactivity glass is by SiO
2, CaO, Na
2O, P
2O
5, becoming through high temperature melting, the proportioning of each composition is:
SiO
2????40-60％?????????????????CaO?????10-30％
Na
2O????10-35％?????????????????P
2O
5?2-8％
B
2O
3???0-10％??????????????????K
2O????0-8％
MgO???????0-5％
It is characterized in that biological activity and the biocompatible glass granule of granule less than 90 μ m, with the granule of granule less than the Remineralization effective dose of 10 μ m, the bioactivity glass that becomes through high temperature melting has effect to treatment gingivitis, dental hemorrhage and releasing odontoseisis symptom.
2, according to being described bioactive glass treatment gingivitis, the dental hemorrhage of claim 1 and the effect of removing the odontoseisis symptom, it is characterized in that bioactivity glass works with toothpaste or solution form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012897 CN1562075A (en) | 2004-03-25 | 2004-03-25 | Use of biological active glass to treat gingivits, cyttarrhagia and odontoseisis syndrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012897 CN1562075A (en) | 2004-03-25 | 2004-03-25 | Use of biological active glass to treat gingivits, cyttarrhagia and odontoseisis syndrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1562075A true CN1562075A (en) | 2005-01-12 |
Family
ID=34478045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410012897 Pending CN1562075A (en) | 2004-03-25 | 2004-03-25 | Use of biological active glass to treat gingivits, cyttarrhagia and odontoseisis syndrom |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1562075A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258432A (en) * | 2010-05-31 | 2011-11-30 | 常州倍尔生生物科技有限公司 | pH buffering bioactive glass, preparation thereof and application thereof |
| CN102862985A (en) * | 2012-10-23 | 2013-01-09 | 徐阳波 | Preparation of hydrolysable calcium potassium phosphosilicate active materials and application thereof |
| CN104116644A (en) * | 2013-04-25 | 2014-10-29 | 林峰辉 | Anti-sensitivity toothpaste |
| CN104606064A (en) * | 2014-12-30 | 2015-05-13 | 北京刷新活力健康科技有限公司 | Biologic active mineral powder chewing gum and preparation method thereof |
| CN104983592A (en) * | 2009-04-01 | 2015-10-21 | 高露洁-棕榄公司 | Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization |
| CN106924090A (en) * | 2017-03-22 | 2017-07-07 | 吉林大学 | A kind of preparation and application of the immobilized lysozyme toothpaste of multistage hole bioactive glass |
| CN107811890A (en) * | 2017-10-31 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | A kind of oral cavity caring toothpaste composition |
| CN114344194A (en) * | 2021-12-28 | 2022-04-15 | 华熙生物科技股份有限公司 | Oral care composition containing hyaluronic acid or salt thereof, application and product thereof |
-
2004
- 2004-03-25 CN CN 200410012897 patent/CN1562075A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983592A (en) * | 2009-04-01 | 2015-10-21 | 高露洁-棕榄公司 | Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization |
| US9937365B2 (en) | 2009-04-01 | 2018-04-10 | Colgate-Palmolive Company | Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization |
| CN102258432A (en) * | 2010-05-31 | 2011-11-30 | 常州倍尔生生物科技有限公司 | pH buffering bioactive glass, preparation thereof and application thereof |
| CN102258432B (en) * | 2010-05-31 | 2012-11-21 | 常州倍尔生生物科技有限公司 | pH buffering bioactive glass, preparation thereof and application thereof |
| CN102862985A (en) * | 2012-10-23 | 2013-01-09 | 徐阳波 | Preparation of hydrolysable calcium potassium phosphosilicate active materials and application thereof |
| CN104116644A (en) * | 2013-04-25 | 2014-10-29 | 林峰辉 | Anti-sensitivity toothpaste |
| CN104606064A (en) * | 2014-12-30 | 2015-05-13 | 北京刷新活力健康科技有限公司 | Biologic active mineral powder chewing gum and preparation method thereof |
| CN106924090A (en) * | 2017-03-22 | 2017-07-07 | 吉林大学 | A kind of preparation and application of the immobilized lysozyme toothpaste of multistage hole bioactive glass |
| CN106924090B (en) * | 2017-03-22 | 2019-06-25 | 吉林大学 | A kind of preparation and application of the immobilized lysozyme toothpaste of multistage hole bioactive glass |
| CN107811890A (en) * | 2017-10-31 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | A kind of oral cavity caring toothpaste composition |
| CN114344194A (en) * | 2021-12-28 | 2022-04-15 | 华熙生物科技股份有限公司 | Oral care composition containing hyaluronic acid or salt thereof, application and product thereof |
| CN114344194B (en) * | 2021-12-28 | 2023-10-20 | 华熙生物科技股份有限公司 | Oral care composition containing hyaluronic acid or salt thereof, application and product thereof |
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