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CN1539376A - Longitudinal scanning method and device in optical coherence tomography system - Google Patents

Longitudinal scanning method and device in optical coherence tomography system Download PDF

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CN1539376A
CN1539376A CNA2003101108388A CN200310110838A CN1539376A CN 1539376 A CN1539376 A CN 1539376A CN A2003101108388 A CNA2003101108388 A CN A2003101108388A CN 200310110838 A CN200310110838 A CN 200310110838A CN 1539376 A CN1539376 A CN 1539376A
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CN1268289C (en
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峰 高
高峰
朱建华
杜惊雷
高福华
郭永康
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Sichuan University
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Abstract

本发明是一种光学相干断层成像系统中纵向扫描方法及其装置。该方法采用一种由可运动棱镜组和静止棱镜组构成的棱镜系统用于纵向扫描装置中,并用微位移器驱动可运动棱镜组,实现高速高精度的线性纵向扫描;该装置包括有光源、光纤、光纤耦合器、透镜等,还包括一个由可运动棱镜组和静止棱镜组构成的棱镜系统及微位移器,可运动棱镜组和静止棱镜组又分别由多个小反射型棱镜、平面反射镜和通光孔构成。本发明具有结构紧凑、简单、对称性好以及可实现高速扫描的优点;并可用传统光学元件加工方法加工棱镜,使得加工精度高,棱镜角度误差可控制在1″以内,本发明采用的是反射器件,可避免光束色散带来的误差。

Figure 200310110838

The invention relates to a longitudinal scanning method and a device thereof in an optical coherence tomography system. The method adopts a prism system composed of a movable prism group and a stationary prism group in the longitudinal scanning device, and drives the movable prism group with a micro-displacement device to realize high-speed and high-precision linear longitudinal scanning; the device includes a light source, Optical fiber, fiber optic coupler, lens, etc., also includes a prism system and a micro-displacement device composed of a movable prism group and a static prism group. The movable prism group and the static prism group are respectively composed of multiple small reflection prisms, plane Composed of mirrors and apertures. The present invention has the advantages of compact structure, simple structure, good symmetry, and high-speed scanning; and the prism can be processed by the traditional optical element processing method, so that the processing precision is high, and the prism angle error can be controlled within 1". The device can avoid errors caused by beam dispersion.

Figure 200310110838

Description

光学相干断层成像系统中纵向扫描方法及其装置Longitudinal scanning method and device in optical coherence tomography system

一、技术领域1. Technical field

本发明涉及光学相干断层成像技术,特别是涉及光学相干断层成像系统中高速纵向扫描方法及其装置。The invention relates to optical coherence tomography technology, in particular to a high-speed longitudinal scanning method and device thereof in an optical coherence tomography system.

二、背景技术2. Background technology

现在发展较为成熟的断层成像技术主要有三种:计算断层成像(Computedtomography)、超声成像(Ultrasonic imaging)和核磁共振成像(Nuclear magneticresonance)。这三种技术各有特点,比如说在其用于人体检查时对人体的损害方面,虽然诊断用X射线的剂量在这些年来已减小了许多,但是仍有不少的资料表明存在着较小的损害效应,可能增加人体感染一些疾病如癌、白血病以及白内障的几率。然而,绝大多数数据都表明现今所用的超声诊断剂量或者核磁共振中相对强的磁场没有任何毒性效应。但是这三种断层成像技术还不能完全满足科学研究与临床诊断对实时、非侵入性以及高分辨率成像的要求(这三种断层图像的分辨率约在100μm~1mm左右)。There are mainly three types of tomographic imaging technologies that have developed relatively maturely: Computed tomography, Ultrasonic imaging and Nuclear magnetic resonance imaging. These three technologies have their own characteristics. For example, in terms of damage to the human body when they are used in human body examinations, although the dose of X-rays used for diagnosis has been reduced a lot in these years, there are still many data showing that there are relatively serious problems. Small damage effects may increase the probability of human infection of some diseases such as cancer, leukemia and cataract. However, the vast majority of data indicate no toxic effects at the diagnostic doses used today in ultrasound or the relatively strong magnetic fields in MRI. However, these three tomographic imaging techniques cannot fully meet the requirements of scientific research and clinical diagnosis for real-time, non-invasive, and high-resolution imaging (the resolution of these three tomographic images is about 100 μm to 1 mm).

1991年麻省理工学院(MIT)的黄大卫(David Huang)等人将低相干光反射仪(Low-coherence reflectometry)与共焦显微镜的原理应用到生物医学断层成像领域中,提出了光学相干断层成像(Optical Coherence Tomography),在这十几年的发展中,光学相干断层成像(OCT)以其无损伤成像、成像分辨率高、系统结构简单、造价低廉等优点而备受科学和工程研究者的瞩目。In 1991, David Huang of the Massachusetts Institute of Technology (MIT) applied the principles of low-coherence reflectometry and confocal microscopy to the field of biomedical tomography, and proposed optical coherence tomography ( Optical Coherence Tomography), in the past ten years of development, optical coherence tomography (OCT) has attracted the attention of scientific and engineering researchers for its advantages of non-destructive imaging, high imaging resolution, simple system structure, and low cost. .

光学相干断层成像(OCT)可以应用在其它成像技术存在潜在缺点的许多领域,特别是为精细的外科手术提供参考数据。例如,脑科手术中,传统的活组织切片检查是非常危险的,而其它成像技术由于分辨率太低而带来了很多局限性;又如对早期视网膜疾病的诊断,需要微米量级的成像技术,目前为止,还没有比光学相干断层成像(OCT)更合适的成像技术。Optical coherence tomography (OCT) can be used in many areas where other imaging techniques have potential shortcomings, especially in providing reference data for delicate surgical procedures. For example, in brain surgery, traditional biopsy is very dangerous, and other imaging techniques have many limitations due to their low resolution; another example is the diagnosis of early retinal diseases, which require micron-scale imaging Technology, so far, there is no more suitable imaging technique than optical coherence tomography (OCT).

光学相干断层成像(OCT)的基本原理是通过光纤式迈克耳孙干涉仪使信号臂上的待测生物体的后向散射光,与参考臂上被全反镜反射回来的参考光进行干涉,检测该干涉信号即可得到待测生物体的信息。其中通过参考臂全反镜沿光轴方向的往返运动实现对待测生物体深度方向的扫描,即纵向扫描,通过沿光轴垂直的方向移动信号臂实现对待测生物体的横向扫描。由于光源使用低相干光源,其相干长度短,因此参考臂和信号臂的长度之差在相干长度内时,才能发生干涉现象,因此,待测生物体成像的纵向分辨率取决于光的相干长度lcThe basic principle of optical coherence tomography (OCT) is to make the backscattered light of the organism to be measured on the signal arm interfere with the reference light reflected by the total mirror on the reference arm through a fiber-optic Michelson interferometer. The information of the organism to be measured can be obtained by detecting the interference signal. The to-and-fro movement of the total mirror of the reference arm along the direction of the optical axis realizes the scanning of the depth direction of the organism to be measured, that is, the longitudinal scanning, and the horizontal scanning of the organism to be measured is realized by moving the signal arm along the direction perpendicular to the optical axis. Since the light source uses a low-coherence light source and its coherence length is short, the interference phenomenon can only occur when the difference between the length of the reference arm and the signal arm is within the coherence length. Therefore, the longitudinal resolution of the imaging of the organism to be measured depends on the coherence length of the light l c :

ll cc == 44 lnln 22 ππ λλ 00 22 ΔλΔλ -- -- -- (( 11 ))

其中,λ0为中心波长,Δλ为光源的带宽(Bandwidth FWHM)。由于光信号是往返的,因此成像纵向分辨率为lc的一半。如,使用中心波长为830nm,带宽为25nm的超发光二极管(SLD)时,成像的纵向分辨率为12μm,如果使用图像恢复技术可以将分辨率提升到微米甚至亚微米量级。Among them, λ 0 is the center wavelength, and Δλ is the bandwidth of the light source (Bandwidth FWHM). Since the optical signal is round-trip, the imaging longitudinal resolution is half of that of lc . For example, when using a superluminescent diode (SLD) with a center wavelength of 830nm and a bandwidth of 25nm, the longitudinal resolution of imaging is 12 μm. If image restoration technology is used, the resolution can be improved to the order of microns or even submicrons.

光学相干断层成像(OCT)系统中的关键部件可以归为三个部分:光源、干涉仪和扫描装置。The key components in an optical coherence tomography (OCT) system can be classified into three parts: light source, interferometer and scanning device.

光源必须满足三个基本条件:近红外光谱、短相干长度、高辐照度。由于光频率较高(蓝光或更高)时,平均散射长度较短,因此光学相干断层成像(OCT)需要长波光源,但是在2μm或更长的波段,水的吸收系数增大,因此只能选择波长在1.8μm以下的波段。另一方面,如果波长越短,分辨率越高,相应的,如果波长增大,为保持同样的分辨率,光源的带宽必须以2次方的趋势增大,因此,为了方便选择光源,应尽量选择短波光源,然而由于血红蛋白在700nm以下吸收系数较大,而且考虑到散射长度的关系,一般将光源波长选择在850nm附近。The light source must meet three basic conditions: near-infrared spectrum, short coherence length, and high irradiance. Optical coherence tomography (OCT) requires a long-wave light source due to the short average scattering length at higher light frequencies (blue light or higher), but at 2 μm or longer, the absorption coefficient of water increases, so only Select a band with a wavelength below 1.8 μm. On the other hand, if the wavelength is shorter, the resolution is higher. Correspondingly, if the wavelength increases, in order to maintain the same resolution, the bandwidth of the light source must increase with the trend of the power of 2. Therefore, in order to facilitate the selection of the light source, the Try to choose a short-wave light source. However, due to the large absorption coefficient of hemoglobin below 700nm, and considering the relationship between the scattering length, the wavelength of the light source is generally selected around 850nm.

干涉仪是基于迈克耳孙干涉仪的结构,通常的光学相干断层成像(OCT)系统均使用光纤结构,虽然光纤连接使得光路灵活、简化了很多,但也带来了系统效率的限制,由于使用的是宽带光源,因此光纤的色散将会使纵向分辨率大大降低。The interferometer is based on the structure of the Michelson interferometer. The optical coherence tomography (OCT) system usually uses the optical fiber structure. Although the optical fiber connection makes the optical path flexible and simplifies a lot, it also brings the limitation of the system efficiency. Due to the use of What is used is a broadband light source, so the dispersion of the fiber will greatly reduce the longitudinal resolution.

扫描装置的纵向扫描速度与分辨率在光学相干断层成像(OCT)中处于同等重要的地位。对高分辨率成像系统而言,待测生物体的微小移动就可能导致图像的模糊,因此只有提高扫描速度才可以克服这种弊病。现有的纵向扫描技术大概分为以下6种:The longitudinal scanning speed and resolution of the scanning device are equally important in optical coherence tomography (OCT). For high-resolution imaging systems, the slight movement of the organism to be measured may cause image blurring, so only by increasing the scanning speed can this disadvantage be overcome. The existing vertical scanning technologies can be roughly divided into the following six types:

1、步进电机驱动反射镜实现扫描。优点:线性、控制方便、价格低廉;缺点:速度慢、往复运动时定位精度差。1. The stepper motor drives the mirror to realize scanning. Advantages: linearity, convenient control, and low price; Disadvantages: slow speed, poor positioning accuracy during reciprocating motion.

2、用压电晶体实现扫描。优点:高速、近似线性、控制方便、价格低廉;缺点:位移量较小、晶体易碎。2. Realize scanning with piezoelectric crystal. Advantages: high speed, approximate linearity, convenient control, low price; Disadvantages: small displacement, fragile crystal.

3、拉伸光纤实现扫描。优点:结构简单、控制方便、价格低廉;缺点:非线性、光束偏振态变化。3. Stretch the optical fiber to realize scanning. Advantages: simple structure, convenient control, and low price; Disadvantages: nonlinearity, changes in the polarization state of the beam.

4、用旋转棱镜实现扫描。优点:高速、控制方便、价格低廉;缺点:非线性、占空比低、光束通过棱镜有色散。4. Realize scanning with rotating prism. Advantages: high speed, convenient control, and low price; Disadvantages: nonlinearity, low duty cycle, and dispersion of light beams passing through prisms.

5、光学延迟线实现扫描。优点:高速、近似线性;缺点:有一定占空比、结构复杂。5. Optical delay line realizes scanning. Advantages: high speed, approximately linear; Disadvantages: certain duty cycle, complex structure.

6、用螺旋镜实现扫描。优点:高速、线性、结构简单、反射型;缺点:加工精度难以保证。6. Realize scanning with spiral mirror. Advantages: high speed, linearity, simple structure, reflective type; Disadvantages: difficult to guarantee processing accuracy.

可以看出,这些纵向扫描技术各有其优缺点,其中步进电机驱动反射镜实现扫描是第一代的纵向扫描技术,已经被其它的多种技术所取代。It can be seen that each of these vertical scanning technologies has its own advantages and disadvantages, among which the stepping motor drives the mirror to realize the scanning is the first generation of vertical scanning technology, which has been replaced by many other technologies.

光学延迟线实现纵向扫描是目前使用较多的方法,其结构较为复杂,并且是通过振镜的角度摆动实现纵向扫描的,因此,只能在小角度上近似线性。Optical delay line is the most used method to realize vertical scanning at present. Its structure is relatively complicated, and the vertical scanning is realized through the angular swing of the galvanometer. Therefore, it can only approximate linearity at small angles.

用螺旋镜实现纵向扫描具有高速、线性、结构简洁等优点,由于是直接反射型的元件,因此光束没有色散问题,只是无法使用传统的光学元件加工方法,因此不得不采用机械加工手段。由于其结构上的特点,必须为其单独配置所需加工工具,而且很难打磨出所需的光学表面,即很难达到微米量级的精度。Longitudinal scanning with a spiral mirror has the advantages of high speed, linearity, and simple structure. Because it is a direct reflection type element, the beam has no dispersion problem, but the traditional optical element processing method cannot be used, so mechanical processing methods have to be used. Due to its structural characteristics, the required processing tools must be configured separately, and it is difficult to polish the required optical surface, that is, it is difficult to achieve micron-level precision.

利用压电陶瓷的电致伸缩效应,可实现亚微米量级定位精度和纳米量级分辨率的微位移,虽然也存在迟滞的缺点,但由于迟滞的原因是介质的介电常数与电场强度的变化史有关而造成的,因此如果采用直接控制电极化强度的方法,在开环状态下,将可以有效解决压电陶瓷的迟滞现象,也可通过增加微位移传感器实现闭环控制来解决压电陶瓷的迟滞现象。但是现有的压电/电致伸缩陶瓷只能实现从几微米到一百多微米位移量,其位移量较小,例如利用压电/电致伸缩陶瓷驱动反射镜均不能满足光学相干断层成像(OCT)系统中需要达到2mm至3mm纵向扫描深度的要求。Utilizing the electrostrictive effect of piezoelectric ceramics, it is possible to achieve submicron-level positioning accuracy and micro-displacement with nanometer-level resolution. Although there are also disadvantages of hysteresis, the reason for the hysteresis is the difference between the dielectric constant of the medium and the electric field strength. Therefore, if the method of directly controlling the electric polarization intensity is used, the hysteresis phenomenon of piezoelectric ceramics can be effectively solved in the open-loop state, and the piezoelectric ceramics can also be solved by adding a micro-displacement sensor to achieve closed-loop control. hysteresis phenomenon. However, the existing piezoelectric/electrostrictive ceramics can only achieve a displacement from a few microns to more than one hundred microns, and the displacement is relatively small. For example, the use of piezoelectric/electrostrictive ceramics to drive mirrors cannot meet the requirements of optical coherence tomography. (OCT) system needs to meet the requirement of 2mm to 3mm longitudinal scan depth.

三、发明内容3. Contents of the invention

本发明的目的正是为了克服上述现有纵向扫描技术所存在的缺陷,提供一种在光学相干断层成像系统中纵向扫描的方法及其装置,解决了现有微位移器驱动反射镜不能满足光学相干断层成像系统中需要达到2mm至3mm纵向扫描深度的要求,并能够直接利用高精度的传统光学元件加工方法加工所需的光学棱镜,从而实现高速高精度的线性扫描,进而提高测量的精确性。The purpose of the present invention is to overcome the defects of the above-mentioned existing longitudinal scanning technology, provide a method and device for longitudinal scanning in the optical coherence tomography system, and solve the problem that the existing micro-displacement drive mirror cannot meet the requirements of optical technology. The coherence tomography system needs to meet the requirement of longitudinal scanning depth of 2mm to 3mm, and can directly use the high-precision traditional optical element processing method to process the required optical prism, so as to realize high-speed and high-precision linear scanning, thereby improving the accuracy of measurement .

本发明的目的是通过下述技术方案实现的:The purpose of the present invention is achieved through the following technical solutions:

本发明光学相干断层成像系统中纵向扫描的方法,采用一种由可运动棱镜组和静止棱镜组构成的棱镜系统,用于本发明光学相干断层成像系统的纵向扫描装置中,再利用微位移器驱动棱镜系统中的可运动棱镜组,由压电/电致伸缩陶瓷等高精度微位移器的平移运动实现高速高精度的纵向扫描。The method for longitudinal scanning in the optical coherence tomography system of the present invention adopts a prism system composed of a movable prism group and a stationary prism group, which is used in the longitudinal scanning device of the optical coherence tomography system of the present invention, and then uses a micro-displacement device The movable prism group in the driving prism system realizes high-speed and high-precision longitudinal scanning by the translational movement of high-precision micro-displacement devices such as piezoelectric/electrostrictive ceramics.

本发明光学相干断层成像系统中纵向扫描装置,包括有光源、光纤、光纤耦合器、透镜、数据采集系统、数据终端等元器件,光源与光纤连接,光纤与光纤耦合器连接,光纤耦合器又分别与两光纤连接,即经过光纤耦合器的光分为两束光分别进入两光纤,一光纤引出的光束进入两透镜实现准直和聚焦后再到待测生物体,按照本发明所说的装置还包括一个由静止棱镜组和可运动棱镜组构成的棱镜系统以及用以驱动可运动棱镜组的微位移器,静止棱镜组置于一准直透镜的后方,棱镜系统中的可运动棱镜组固定在微位移器上,并置于静止棱镜组后方,可运动棱镜组与静止棱镜组须配对使用。The longitudinal scanning device in the optical coherence tomography system of the present invention includes components such as light source, optical fiber, optical fiber coupler, lens, data acquisition system, data terminal, etc., the light source is connected with the optical fiber, the optical fiber is connected with the optical fiber coupler, and the optical fiber coupler is They are respectively connected to two optical fibers, that is, the light passing through the fiber coupler is divided into two beams of light and enters the two optical fibers respectively, and the light beam drawn from one optical fiber enters the two lenses to achieve collimation and focusing before reaching the organism to be measured. According to the present invention The device also includes a prism system composed of a stationary prism group and a movable prism group and a micro displacement device for driving the movable prism group, the stationary prism group is placed behind a collimator lens, and the movable prism group in the prism system It is fixed on the micro-displacement device and placed behind the stationary prism group. The movable prism group and the stationary prism group must be used in pairs.

本装置棱镜系统中的可运动棱镜组和静止棱镜组又分别由多个小反射型棱镜、平面反射镜和通光孔构成。棱镜系统的结构随可运动棱镜组和静止棱镜组结构参数的不同而有差别。可运动棱镜组和静止棱镜组的具体结构参数包括:每一个小反射型棱镜的长度、宽度和高度;棱镜组的长度和宽度;棱镜组长度方向的小反射型棱镜的个数;棱镜组宽度方向的小反射型棱镜的个数;通光孔的位置;是否有平面反射镜以及平面反射镜的位置。The movable prism group and the static prism group in the prism system of the device are respectively composed of a plurality of small reflective prisms, plane reflectors and light holes. The structure of the prism system varies with the structural parameters of the movable prism group and the static prism group. The specific structural parameters of the movable prism group and the stationary prism group include: the length, width and height of each small reflective prism; the length and width of the prism group; the number of small reflective prisms in the length direction of the prism group; the width of the prism group The number of small reflective prisms in the direction; the position of the light hole; whether there is a plane reflector and the position of the plane reflector.

本发明与现有技术相比具有如下优点:Compared with the prior art, the present invention has the following advantages:

1、本发明采用的棱镜系统由许多小反射型棱镜组装而成,因此可以使用传统的光学元件加工方法加工棱镜,其加工精度高,棱镜角度误差可控制在1″以内。1. The prism system adopted in the present invention is assembled from many small reflective prisms. Therefore, traditional optical element processing methods can be used to process the prisms. The processing accuracy is high, and the prism angle error can be controlled within 1 ".

2、本发明使用压电/电致伸缩陶瓷等高精度微位移器驱动棱镜系统中可运动棱镜组,由于压电/电致伸缩陶瓷具有很高的响应速度(几十微秒),正因为其响应速度快,它的机电耦合效应进行的速度也就很快,来不及与外界热交换,因此不存在发热问题,能达到高速、无机械摩擦、同时没有噪声的纵向扫描。2. The present invention uses high-precision micro-displacement devices such as piezoelectric/electrostrictive ceramics to drive the movable prism group in the prism system. Because piezoelectric/electrostrictive ceramics have a very high response speed (tens of microseconds), just because Its response speed is fast, and the speed of its electromechanical coupling effect is very fast, and it is too late to exchange heat with the outside world, so there is no heating problem, and it can achieve high-speed, no mechanical friction, and no noise longitudinal scanning.

3、本发明使用的压电/电致伸缩陶瓷微位移器,其体积一般很小,与本发明的棱镜系统配合使用,具有结构紧凑、体积小的优点。3. The piezoelectric/electrostrictive ceramic micro-displacement device used in the present invention is generally small in size, and used in conjunction with the prism system of the present invention, it has the advantages of compact structure and small volume.

4、本发明采用的棱镜系统中可运动棱镜组的结构简单,对称性好,因此减小了运动中的不稳定因素,进而提高测量精度。4. The structure of the movable prism group in the prism system adopted by the present invention is simple and the symmetry is good, so the unstable factors in the movement are reduced, and the measurement accuracy is further improved.

5、本发明采用的棱镜系统是一种全反射元件,避免了色散问题。5. The prism system used in the present invention is a total reflection element, which avoids the dispersion problem.

四、附图说明4. Description of drawings

图1是本发明棱镜系统用于光学相干断层成像系统中的连接示意图。Fig. 1 is a schematic diagram of the connection of the prism system of the present invention used in an optical coherence tomography system.

图2是本发明棱镜系统中与图3配对的具有4×4个区域的可运动棱镜组的结构示意图。FIG. 2 is a structural schematic diagram of a movable prism group with 4×4 regions paired with FIG. 3 in the prism system of the present invention.

图3是本发明棱镜系统中具有4×4个区域的静止棱镜组的结构示意图。FIG. 3 is a schematic structural diagram of a stationary prism group with 4×4 regions in the prism system of the present invention.

图4是本发明棱镜系统中与图5配对的具有6×6个区域的可运动棱镜组的结构示意图。FIG. 4 is a schematic structural diagram of a movable prism group with 6×6 regions paired with FIG. 5 in the prism system of the present invention.

图5是本发明棱镜系统中具有6×6个区域的静止棱镜组的结构示意图。Fig. 5 is a schematic structural diagram of a stationary prism group with 6*6 regions in the prism system of the present invention.

图6是本发明棱镜系统中与图7配对的具有4×4个区域的可运动棱镜组的结构示意图。FIG. 6 is a structural schematic diagram of a movable prism group with 4×4 regions paired with FIG. 7 in the prism system of the present invention.

图7是本发明棱镜系统中具有4×4个区域并包括两个通光孔的静止棱镜组的结构示意图。FIG. 7 is a schematic structural diagram of a static prism group with 4×4 regions and two light holes in the prism system of the present invention.

图8是本发明使用棱镜系统的二维等效光路图。Fig. 8 is a two-dimensional equivalent light path diagram of the prism system used in the present invention.

五、具体实施方式5. Specific implementation

下面结合附图,通过实施例对本发明作进一步的说明。但本发明的内容不仅限于实施例中所涉及的内容。Below in conjunction with accompanying drawing, the present invention will be further described through embodiment. But the content of the present invention is not limited to the content involved in the embodiment.

本发明光学相干断层成像系统中纵向扫描方法,采用由可运动棱镜组112和静止棱镜组111构成的棱镜系统,用于光学相干断层成像系统的纵向扫描装置中,再利用压电/电致伸缩陶瓷微位移器113驱动棱镜系统中的可运动棱镜组112,通过压电/电致伸缩陶瓷微位移器113的平移运动实现高速高精度的线性纵向扫描。The longitudinal scanning method in the optical coherence tomography system of the present invention adopts a prism system composed of a movable prism group 112 and a stationary prism group 111, which is used in the longitudinal scanning device of the optical coherence tomography system, and then uses piezoelectric/electrostrictive The ceramic micro-displacer 113 drives the movable prism group 112 in the prism system, and high-speed and high-precision linear longitudinal scanning is realized through the translational movement of the piezoelectric/electrostrictive ceramic micro-displacer 113 .

参照图1,本发明光学相干断层成像系统中纵向扫描装置,包括有光源11、光纤12、14、15、光纤耦合器13、透镜16、17、数据采集系统115、数据终端116等元器件,光源11与光纤12连接,光纤12与光纤耦合器13连接,光纤耦合器13又分别与光纤14和光纤15连接,即经过光纤耦合器的光分为两束光分别进入光纤14和光纤15,由光纤14引出的光束进入透镜16和透镜17实现准直和聚焦后再到待测生物体18,按照本发明所说的装置还包括一个由可运动棱镜组112和静止棱镜组111构成的棱镜系统,以及用以驱动可运动棱镜组112的压电/电致伸缩陶瓷微位移器113,由光纤15引出的光束进入准直透镜110,静止棱镜组111置于准直透镜110的后方,可运动棱镜组112固定在微位移器113上,并置于静止棱镜组后方,可运动棱镜组与静止棱镜组须配对使用。Referring to Fig. 1, the longitudinal scanning device in the optical coherence tomography system of the present invention includes components such as light source 11, optical fibers 12, 14, 15, optical fiber coupler 13, lenses 16, 17, data acquisition system 115, data terminal 116, etc. The light source 11 is connected with the optical fiber 12, the optical fiber 12 is connected with the optical fiber coupler 13, and the optical fiber coupler 13 is respectively connected with the optical fiber 14 and the optical fiber 15, that is, the light passing through the optical fiber coupler is divided into two bundles of light and enters the optical fiber 14 and the optical fiber 15 respectively, The light beam drawn by the optical fiber 14 enters the lens 16 and the lens 17 to achieve collimation and focusing, and then reaches the organism 18 to be measured. According to the present invention, the device also includes a prism composed of a movable prism group 112 and a stationary prism group 111. system, and the piezoelectric/electrostrictive ceramic micro-displacement device 113 used to drive the movable prism group 112, the light beam drawn by the optical fiber 15 enters the collimating lens 110, and the stationary prism group 111 is placed at the rear of the collimating lens 110, which can The movable prism group 112 is fixed on the micro-displacement device 113 and placed behind the static prism group, and the movable prism group and the static prism group must be used in pairs.

实现扫描的过程是:从光源11发出的光束耦合到光纤12中,光束经过光纤12后进入2×2光纤耦合器13,然后分为两束分别进入光纤14和光纤15。The scanning process is as follows: the light beam emitted from the light source 11 is coupled into the optical fiber 12, the light beam enters the 2×2 fiber coupler 13 after passing through the optical fiber 12, and then is divided into two beams and enters the optical fiber 14 and the optical fiber 15 respectively.

第一束光经过光纤14传输后通过透镜16准直,再经过透镜17聚焦到待测生物体18上,待测生物体18的后向散射光又由透镜17收集后传输到透镜16聚焦耦合进入光纤14,再由光纤14进入2×2光纤耦合器13,并传输到探测器114。其中按图中箭头方向移动由光纤14、透镜16和透镜17组成的整体19来实现对待测生物体18的横向扫描。The first beam of light is collimated by the lens 16 after being transmitted by the optical fiber 14, and then focused on the organism 18 to be measured by the lens 17, and the backscattered light of the organism 18 to be measured is collected by the lens 17 and transmitted to the lens 16 for focusing and coupling Enter the optical fiber 14, then enter the 2×2 fiber coupler 13 through the optical fiber 14, and transmit to the detector 114. The whole body 19 composed of the optical fiber 14 , the lens 16 and the lens 17 is moved in the direction of the arrow in the figure to realize the transverse scanning of the biological object 18 to be tested.

第二束光经过光纤15传输后通过准直透镜110准直,再进入棱镜系统的静止棱镜组111,通过棱镜系统的静止棱镜组111和可运动棱镜组112的来回反射后,再由棱镜系统中的静止棱镜组111出射,出射的光束仍由准直透镜110收集,并耦合到光纤15中,再通过2×2光纤耦合器13传输到探测器114。其中由压电/电致伸缩陶瓷113按图中箭头方向平移棱镜系统中的可运动棱镜组112来实现纵向扫描。The second beam of light is collimated by the collimating lens 110 after being transmitted through the optical fiber 15, and then enters the stationary prism group 111 of the prism system, and after being reflected back and forth between the stationary prism group 111 and the movable prism group 112 of the prism system, it is then passed by the prism system The stationary prism group 111 in the prism exits, and the outgoing beam is still collected by the collimator lens 110 , coupled into the optical fiber 15 , and then transmitted to the detector 114 through the 2×2 optical fiber coupler 13 . The piezoelectric/electrostrictive ceramic 113 translates the movable prism group 112 in the prism system in the direction of the arrow in the figure to realize longitudinal scanning.

探测器114将这两束光的干涉光信号转换为电信号进入数据采集系统115,最后进入数据终端116处理得出断层图像。The detector 114 converts the interference optical signal of the two beams of light into an electrical signal, enters the data acquisition system 115, and finally enters the data terminal 116 for processing to obtain a tomographic image.

本发明设计的棱镜系统的结构随结构参数的不同而有差别,图2、图3、图4、图5、图6、图7就是不同结构参数下的可运动棱镜组和静止棱镜组的结构,图中黑色的部分代表镀上了反射膜,黑色部分上面的白线是为了突出三维结构而作的辅助线,无任何物理意义;白色部分代表未镀反射膜的通光孔,白色部分上面的黑线是为了突出三维结构而作的辅助线,无任何物理意义。The structure of the prism system designed by the present invention varies with structural parameters, and Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 and Fig. 7 are exactly the structures of the movable prism group and the stationary prism group under different structural parameters , the black part in the figure represents the reflective film coated, the white line above the black part is an auxiliary line for highlighting the three-dimensional structure, without any physical meaning; the white part represents the light hole without the reflective film, and the white part above The black lines are auxiliary lines for highlighting the three-dimensional structure, without any physical meaning.

棱镜系统的具体结构参数包括:每一个小反射型棱镜的长度di、宽度d′i和高度hi(其中i下标代表每一个小反射型棱镜的编号);棱镜组的长度l和宽度w;棱镜组长度方向的小反射型棱镜的个数Ni;棱镜组宽度方向的小反射型棱镜的个数Nw;通光孔的位置;是否有平面反射镜以及平面反射镜的位置。The specific structural parameters of the prism system include: length d i , width d′ i and height h i (wherein the subscript i represents the number of each small reflective prism) of each small reflective prism; length l and width of the prism group w; the number N i of small reflective prisms in the length direction of the prism group; the number N w of small reflective prisms in the width direction of the prism group; the position of the light hole; whether there is a plane mirror and the position of the plane mirror.

下面以图2、图3、图4、图5、图6、图7的不同例子说明结构参数可按需选择。Different examples in Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 and Fig. 7 illustrate that the structural parameters can be selected as required.

图2是与图3配合使用的可运动棱镜组,图3为静止棱镜组,两棱镜组均可视为有4×4个区域,每个区域既可放置一个小反射型棱镜或平面反射镜,也可作为通光孔,其中每个区域的长度和宽度即为每一个小反射型棱镜的长度和宽度,即为di=d′i=d(其中i下标代表每一个小反射型棱镜的编号),每一个小反射型棱镜的高度为hi=d;棱镜组的长度l=4d,宽度w=4d;棱镜组长度方向的小反射型棱镜的个数Nl=l/d=4;棱镜组宽度方向的小反射型棱镜的个数Nw=w/d=4;通光孔的位置为图3中的31区域,是光束的入射和出射窗;平面反射镜的位置在图3中的316区域。Figure 2 is a movable prism group used in conjunction with Figure 3, and Figure 3 is a stationary prism group, both prism groups can be regarded as having 4×4 areas, and each area can place a small reflective prism or a plane reflector , can also be used as a light hole, wherein the length and width of each area are the length and width of each small reflective prism, that is, d i =d' i =d (wherein the i subscript represents each small reflective prism prism number), the height of each small reflective prism is hi =d; the length l=4d of the prism group, the width w=4d; the number N l of the small reflective prisms in the length direction of the prism group N l =l/d =4; the number N w of the small reflective prisms in the width direction of the prism group N w =w/d=4; the position of the light passing hole is the 31 area in Fig. 3, which is the incident and exit window of the light beam; the position of the plane reflector In the 316 area in Figure 3.

图4是与图5配合使用的可运动棱镜组,图5为静止棱镜组,两棱镜组均可视为有6×6个区域,每个区域既可放置一个小反射型棱镜或平面反射镜,也可作为通光孔,其中每个区域的长度和宽度即为每一个小反射型棱镜的长度和宽度,即为di=d′i=d(其中i下标代表每一个小反射型棱镜的编号),每一个小反射型棱镜的高度为hi=d;棱镜组的长度l=6d,宽度w=6d;棱镜组长度方向的小反射型棱镜的个数Nl=l/d=6;棱镜组宽度方向的小反射型棱镜的个数Nw=w/d=6;通光孔的位置为图5中的51区域,是光束的入射和出射窗;平面反射镜的位置在图5中的536区域。Fig. 4 is a movable prism group used in conjunction with Fig. 5, and Fig. 5 is a stationary prism group, both prism groups can be regarded as having 6 × 6 areas, and each area can place a small reflective prism or a plane reflector , can also be used as a light hole, wherein the length and width of each area are the length and width of each small reflective prism, that is, d i =d' i =d (wherein the i subscript represents each small reflective prism prism number), the height of each small reflective prism is hi =d; the length l=6d of the prism group, the width w=6d; the number N l =l/d of the small reflective prisms in the length direction of the prism group =6; the number N w of the small reflective prisms in the width direction of the prism group N w =w/d=6; the position of the light passing hole is the 51 area among Fig. 5, which is the incident and exit window of the light beam; the position of the plane reflector In the 536 area in Figure 5.

图6是与图7配合使用的可运动棱镜组,图7为静止棱镜组,两棱镜组均可视为有4×4个区域,每个区域既可放置一个小反射型棱镜或平面反射镜,也可作为通光孔,其中每个区域的长度和宽度即为每一个小反射型棱镜的长度和宽度,即为di=d′i=d(其中i下标代表每一个小反射型棱镜的编号),每一个小反射型棱镜的高度为hi=d;棱镜组的长度l=4d,宽度w=4d;棱镜组长度方向的小反射型棱镜的个数Nl=l/d=4;棱镜组宽度方向的小反射型棱镜的个数Nw=w/d=4;通光孔的位置为图7中的71区域和716区域,分别是光束的入射和出射窗;没有平面反射镜。Fig. 6 is a movable prism group used in conjunction with Fig. 7, and Fig. 7 is a stationary prism group, both prism groups can be regarded as having 4 × 4 areas, and each area can place a small reflective prism or a plane reflector , can also be used as a light hole, wherein the length and width of each area are the length and width of each small reflective prism, that is, d i =d' i =d (wherein the i subscript represents each small reflective prism prism number), the height of each small reflective prism is hi =d; the length l=4d of the prism group, the width w=4d; the number N l of the small reflective prisms in the length direction of the prism group N l =l/d =4; the number N w of the small reflective prisms in the width direction of the prism group N w =w/d=4; the position of the light passing hole is the 71 area and the 716 area in Fig. 7, which are respectively the incident and exit windows of the light beam; there is no flat mirror.

图8中,通过可运动棱镜组112和静止棱镜组111的二维等效结构,可以推导出需要的棱镜系统的结构参数取值。为了元件加工的方便,这里选择每一个小反射型棱镜的长度、宽度和高度相等,即di=d′i=hi=d。In FIG. 8 , through the two-dimensional equivalent structures of the movable prism group 112 and the stationary prism group 111 , the value of the required structural parameters of the prism system can be deduced. For the convenience of component processing, the length, width and height of each small reflective prism are chosen to be equal, that is, d i =d' i =h i =d.

光束入射后在可运动棱镜组112和静止棱镜组111之间多次反射,最后通过静止棱镜组的平面反射镜83使光束沿原光路返回。当可运动棱镜组112位移Δx时,光束的光程差为After being incident, the light beam is reflected multiple times between the movable prism group 112 and the stationary prism group 111, and finally passes through the plane reflector 83 of the stationary prism group to make the light beam return along the original optical path. When the movable prism group 112 is displaced by Δx, the optical path difference of the light beam is

                    Δl=2NΔx                                  (2)                                          

其中N即为可运动棱镜组112的小反射型棱镜的个数,可运动棱镜组112的位移量Δx由微位移器的位移量决定,使用压电/电致伸缩陶瓷作为微位移器,位移量通常可取在Δx=100μm左右,再使用N=16个棱镜,那么光程差将达到Δl=3.2mm左右,完全可以满足光学相干断层成像系统中需要达到2mm至3mm纵向扫描深度的要求。Wherein N is the number of small reflective prisms of the movable prism group 112, the displacement Δx of the movable prism group 112 is determined by the displacement of the micro-displacer, using piezoelectric/electrostrictive ceramics as the micro-displacer, the displacement The optical path difference is usually around Δx=100μm, and N=16 prisms are used, then the optical path difference will reach about Δl=3.2mm, which can fully meet the requirements of the longitudinal scanning depth of 2mm to 3mm in the optical coherence tomography system.

选择每一个小反射型棱镜的长度、宽度和高度di=d′i=hi=d的取值时,需要考虑传统光学元件加工方法能够高精度加工棱镜的取值范围,这里选择d=10mm。这样取值以后,可以看到,可运动棱镜组112的二维等效结构的长度l=N×d=16×10=160mm,而宽度为一个小反射型棱镜的宽度w=d=10mm。When selecting the value of the length, width and height d i =d' i =h i =d of each small reflective prism, it is necessary to consider the value range of the traditional optical element processing method that can process the prism with high precision, here select d= 10mm. After such values are taken, it can be seen that the length l=N×d=16×10=160mm of the two-dimensional equivalent structure of the movable prism group 112, and the width is the width w=d=10mm of a small reflective prism.

图2中,可运动棱镜组112是将图8中所示的可运动棱镜组112的二维等效结构空间排布成为的三维结构,这种三维结构可以有效的减小棱镜组的大小,提高元件的对称性,如可运动棱镜组的小反射型棱镜个数N=16,每个小反射型棱镜的长度为d=10mm,那么图2所示的三维结构只需取棱镜组长度方向的小反射型棱镜的个数和棱镜组宽度方向的小反射型棱镜的个数相等Nl=Nw=4,就可以实现小反射型棱镜的个数N=Nl×Nw=16,而可运动棱镜组的长度和宽度为l=w=4d=40mm。In Fig. 2, the movable prism group 112 is a three-dimensional structure that the two-dimensional equivalent structure of the movable prism group 112 shown in Fig. 8 is spatially arranged into, and this three-dimensional structure can effectively reduce the size of the prism group, Improve the symmetry of element, as the small reflective prism number N=16 of movable prism group, the length of each small reflective prism is d=10mm, so the three-dimensional structure shown in Fig. 2 only needs to get the prism group length direction The number of small reflective prisms and the number of small reflective prisms in the width direction of the prism group are equal N l = N w = 4, and the number of small reflective prisms N = N l * N w = 16 can be realized. And the length and width of the movable prism group are l=w=4d=40mm.

这样本发明使用的三维结构将可运动棱镜组从长度l=160mm,宽度w=10mm整合为长宽相等即l=w=40mm的结构。这种结构的精简对于提高可运动棱镜组振动过程的稳定性具有重要的作用,特别是可运动棱镜组需要以大于100Hz的频率振动,那么其对称性的提高将会有效提高运动的稳定性。In this way, the three-dimensional structure used in the present invention integrates the movable prism group from length l=160mm and width w=10mm into a structure with equal length and width, that is, l=w=40mm. The simplification of this structure plays an important role in improving the stability of the vibration process of the movable prism group, especially the movable prism group needs to vibrate at a frequency greater than 100 Hz, so the improvement of its symmetry will effectively improve the stability of the movement.

现用图2、图3所示的棱镜系统来描述光束在棱镜系统中的传输过程,光束由静止棱镜组的通光孔31入射到可运动棱镜组的小反射型棱镜21上,经小反射型棱镜21反射到小反射型棱镜22上,光束经小反射型棱镜22反射到静止棱镜组的小反射型棱镜32上,再反射到小反射型棱镜33,又由小反射型棱镜33反射到可运动棱镜组的小反射型棱镜23,再反射到小反射型棱镜24,再反射到静止棱镜组的小反射型棱镜34,由于小反射型棱镜34和小反射型棱镜35的方向不同,光束由小反射型棱镜34反射到小反射型棱镜35后,将会反射到可运动棱镜组的下一排棱镜的小反射型棱镜25上,从而重复前面的反射过程,最后由静止棱镜组的平面反射镜316将光束沿原路返回到入射时的通光孔31后出射。其具体的反射过程由可运动棱镜组和静止棱镜组中的通光孔、小反射型棱镜和平面反射镜的编号描述为:31→21→22→32→33→23→24→34→35→25→26→36→37→27→28→38→39→29→210→310→311→211→212→312→313→213→214→314→315→215→216→316→216→215→315→314→214→213→313→312→212→211→311→310→210→29→39→38→28→27→37→36→26→25→35→34→24→23→33→32→22→21→31。Now use the prism system shown in Figure 2 and Figure 3 to describe the transmission process of the light beam in the prism system. The small reflective prism 21 is reflected on the small reflective prism 22, and the light beam is reflected on the small reflective prism 32 of the stationary prism group through the small reflective prism 22, then reflected to the small reflective prism 33, and then reflected by the small reflective prism 33 to The small reflective prism 23 of the movable prism group is reflected to the small reflective prism 24, and then reflected to the small reflective prism 34 of the stationary prism group. Because the directions of the small reflective prism 34 and the small reflective prism 35 are different, the light beam After being reflected by the small reflective prism 34 to the small reflective prism 35, it will be reflected on the small reflective prism 25 of the next row of prisms in the movable prism group, thereby repeating the previous reflection process, finally by the plane of the stationary prism group The reflector 316 returns the light beam along the original path to the incident light hole 31 and then exits. Its specific reflection process is described by the numbers of the light holes, small reflective prisms and plane mirrors in the movable prism group and the stationary prism group: 31→21→22→32→33→23→24→34→35 →25→26→36→37→27→28→38→39→29→210→310→311→211→212→312→313→213→214→314→315→215→216→316→216→215 →315→314→214→213→313→312→212→211→311→310→210→29→39→38→28→27→37→36→26→25→35→34→24→23→33 →32→22→21→31.

图2所示的可运动棱镜组的结构虽然是由Nl=Nw=4;di=d′i=hi=d=10mm的4×4=16个小反射型棱镜胶合而成,但在使用传统光学元件加工方法制作时,可以将其视为3个棱镜来加工和胶合。第1个需加工的棱镜是由小反射型棱镜21、小反射型棱镜28、小反射型棱镜29、小反射型棱镜216组合而成的10mm×40mm的棱镜;第2个需加工的棱镜是由小反射型棱镜22、小反射型棱镜27、小反射型棱镜210、小反射型棱镜215、小反射型棱镜23、小反射型棱镜26、小反射型棱镜211、小反射型棱镜214组合而成的20mm×40mm的棱镜;第3个需加工的棱镜是由小反射型棱镜24、小反射型棱镜25、小反射型棱镜212、小反射型棱镜213组合而成的10mm×40mm的棱镜。其中第1个需加工的棱镜和第3个需加工的棱镜的形状和尺寸均一样,可批量加工。Although the structure of the movable prism group shown in Fig . 2 is glued together by N l = N w = 4; But when using the traditional optical element processing method, it can be processed and glued as three prisms. The first prism to be processed is a 10mm×40mm prism composed of small reflective prism 21, small reflective prism 28, small reflective prism 29, and small reflective prism 216; the second prism to be processed is Combination of small reflective prism 22, small reflective prism 27, small reflective prism 210, small reflective prism 215, small reflective prism 23, small reflective prism 26, small reflective prism 211, and small reflective prism 214 The prism of the 20mm * 40mm that becomes; The 3rd prism that needs processing is the prism of 10mm * 40mm that is combined by small reflective prism 24, small reflective prism 25, small reflective prism 212, small reflective prism 213. The shape and size of the first prism to be processed and the third prism to be processed are the same and can be processed in batches.

图3所示的静止棱镜组的结构虽然由Nl=Nw=4;di=d′i=hi=d=10mm的4×4=16个区域组成,其中有小反射型棱镜14个,平面反射镜1个和通光孔1个,但在使用传统光学元件加工方法制作时,可以将其视为8个棱镜和1个平面反射镜来加工和胶合。其中有6个需加工的棱镜的形状和尺寸均一样,即小反射型棱镜34;小反射型棱镜35;小反射型棱镜312;小反射型棱镜313;小反射型棱镜38;小反射型棱镜39的形状和尺寸均一样,可批量加工;第7个需加工的棱镜是由小反射型棱镜32、小反射型棱镜37、小反射型棱镜310、小反射型棱镜315组合而成的10mm×40mm的棱镜;第8个需加工的棱镜是由小反射型棱镜33、小反射型棱镜36、小反射型棱镜311、小反射型棱镜314组合而成的10mm×40mm的棱镜,第7个需加工的棱镜和第8个需加工的棱镜的形状和尺寸均一样,可批量加工。再加工一个尺寸为10mm×10mm的平面反射镜,胶合在区域316位置即可。Although the structure of the static prism group shown in Fig . 3 is made up of 4× 4 =16 regions of N l =N w =4; 1, 1 plane mirror and 1 light hole, but when using traditional optical element processing methods, it can be processed and glued as 8 prisms and 1 plane mirror. Among them, the shape and size of 6 prisms to be processed are all the same, that is, small reflective prism 34; small reflective prism 35; small reflective prism 312; small reflective prism 313; small reflective prism 38; small reflective prism 39 have the same shape and size and can be processed in batches; the 7th prism to be processed is a 10mm× 40mm prism; the eighth prism to be processed is a 10mm×40mm prism composed of small reflective prism 33, small reflective prism 36, small reflective prism 311, and small reflective prism 314; The processed prism has the same shape and size as the eighth prism to be processed, and can be processed in batches. Then process a flat reflector with a size of 10mm×10mm, and glue it on the position of area 316.

Claims (4)

1, the method for longitudinal scanning in a kind of optical coherence tomography system, it is characterized in that adopting a kind of prism system that constitutes by movable prism group (112) and stationary prism group (111) to be used in the longitudinal scan device of optical coherence tomography system, utilize the movable prism group (112) in micro positioner (113) the driving prism system again, realize the longitudinal scanning of high-speed, high precision by the translational motion of micro positioner.
2, longitudinal scan device in a kind of optical coherence tomography system, include light source (11), optical fiber (12), (14), (15) and fiber coupler (13), lens (16), (17), data collecting system (115), data terminal components and parts such as (116), light source (11) is connected with optical fiber (12), optical fiber (12) is connected with fiber coupler (13), fiber coupler (13) is connected with optical fiber (15) with optical fiber (14) respectively, promptly be divided into two-beam and enter optical fiber (14) and optical fiber (15) respectively through the light of fiber coupler, the light beam of being drawn by optical fiber (14) enters lens (16) and lens (17), arrive organism to be measured (18) again, it is characterized in that said device also comprises one by the prism system of movable prism group (112) and stationary prism group (111) formation and in order to drive the micro positioner (113) of movable prism group (112), the light beam of being drawn by optical fiber (15) enters collimating lens (110), stationary prism group (111) places collimating lens (110) rear, movable prism group (112) is fixed on the micro positioner, and placing stationary prism group rear, movable prism group and stationary prism group must be used in pairing.
3,, it is characterized in that movable prism group (112) and the stationary prism group (111) in the said prism system is made of a plurality of little reflection-type prisms, plane mirror and light hole respectively again according to the described device of claim 2.
4, according to claim 2 or 3 described devices, the structure that it is characterized in that said prism system has difference with movable prism group and stationary prism group structural parameters different, and its concrete structure parameter comprises: the prismatical length of each little reflection-type, width and height; The length of prism group and width; The prismatical number of little reflection-type of prism group length direction; The prismatical number of little reflection-type of prism group width; The position of light hole; The position whether plane mirror and plane mirror are arranged.
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