CN1491672A - Organic state micro element supplement agent - Google Patents
Organic state micro element supplement agent Download PDFInfo
- Publication number
- CN1491672A CN1491672A CNA021283397A CN02128339A CN1491672A CN 1491672 A CN1491672 A CN 1491672A CN A021283397 A CNA021283397 A CN A021283397A CN 02128339 A CN02128339 A CN 02128339A CN 1491672 A CN1491672 A CN 1491672A
- Authority
- CN
- China
- Prior art keywords
- solution
- contain
- selenium
- semen glycines
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013589 supplement Substances 0.000 title claims description 21
- 239000000843 powder Substances 0.000 claims abstract description 38
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000011669 selenium Substances 0.000 claims description 50
- 229910052711 selenium Inorganic materials 0.000 claims description 45
- 239000011573 trace mineral Substances 0.000 claims description 41
- 235000013619 trace mineral Nutrition 0.000 claims description 41
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 39
- 210000000582 semen Anatomy 0.000 claims description 36
- 150000002333 glycines Chemical class 0.000 claims description 33
- 239000011701 zinc Substances 0.000 claims description 26
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 25
- 229910052725 zinc Inorganic materials 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 239000011651 chromium Substances 0.000 claims description 21
- 235000016709 nutrition Nutrition 0.000 claims description 20
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 16
- 229910052804 chromium Inorganic materials 0.000 claims description 16
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 12
- 229910052744 lithium Inorganic materials 0.000 claims description 12
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims description 11
- 229910052720 vanadium Inorganic materials 0.000 claims description 10
- 230000035784 germination Effects 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 6
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 5
- 229960001763 zinc sulfate Drugs 0.000 claims description 5
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 5
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 4
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 229910000166 zirconium phosphate Inorganic materials 0.000 claims description 3
- 244000046052 Phaseolus vulgaris Species 0.000 abstract description 16
- 235000010627 Phaseolus vulgaris Nutrition 0.000 abstract description 16
- 230000001502 supplementing effect Effects 0.000 abstract 3
- 230000002079 cooperative effect Effects 0.000 abstract 1
- 229940091258 selenium supplement Drugs 0.000 description 46
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 30
- 229910052732 germanium Inorganic materials 0.000 description 23
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 22
- 206010012601 diabetes mellitus Diseases 0.000 description 20
- 239000000047 product Substances 0.000 description 19
- 229930003427 Vitamin E Natural products 0.000 description 15
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 15
- 235000019165 vitamin E Nutrition 0.000 description 15
- 229940046009 vitamin E Drugs 0.000 description 15
- 239000011709 vitamin E Substances 0.000 description 15
- 230000036541 health Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 235000015097 nutrients Nutrition 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 230000000366 juvenile effect Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 239000004472 Lysine Substances 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 235000019154 vitamin C Nutrition 0.000 description 4
- 239000011718 vitamin C Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- 229910005793 GeO 2 Inorganic materials 0.000 description 3
- 235000019766 L-Lysine Nutrition 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 229910017053 inorganic salt Inorganic materials 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 230000035790 physiological processes and functions Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 2
- 108010051696 Growth Hormone Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 208000019926 Keshan disease Diseases 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- GNTDGMZSJNCJKK-UHFFFAOYSA-N divanadium pentaoxide Chemical compound O=[V](=O)O[V](=O)=O GNTDGMZSJNCJKK-UHFFFAOYSA-N 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 235000003969 glutathione Nutrition 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 239000000122 growth hormone Substances 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 235000018977 lysine Nutrition 0.000 description 2
- 229940100691 oral capsule Drugs 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 108010075254 C-Peptide Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 229910021555 Chromium Chloride Inorganic materials 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 102100036721 Insulin receptor Human genes 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 102000008114 Selenoproteins Human genes 0.000 description 1
- 108010074686 Selenoproteins Proteins 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 206010048259 Zinc deficiency Diseases 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000003848 cartilage regeneration Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 150000002291 germanium compounds Chemical class 0.000 description 1
- 229940093626 germanium sesquioxide Drugs 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 230000007866 hepatic necrosis Effects 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 description 1
- UUUGYDOQQLOJQA-UHFFFAOYSA-L vanadyl sulfate Chemical compound [V+2]=O.[O-]S([O-])(=O)=O UUUGYDOQQLOJQA-UHFFFAOYSA-L 0.000 description 1
- 208000024877 white muscle disease Diseases 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 229940091251 zinc supplement Drugs 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to organic state micro element supplementing preparation. The organic state micro element supplementing preparation for diabetics consists of Cr-containing bean powder, V-containing bean powder, Li-containing bean powder, Se-containing bean powder and Zn-containing bean powder. The organic state micro element supplementing preparation is compounded according to the features of different groups and has the cooperative effect of different micro elements for body to absorb easily.
Description
The application is that application number is 99124691.8, and the applying date is December in 1999 30 days, and name is called dividing an application of " organic state micro element supplement agent ".
Technical field
The present invention relates to field of health care products, particularly be suitable for the organic state micro element supplement agent that middle-aged and elderly people, diabetes patient, juvenile eat.
Background technology
Trace element has inorganic states and organic two kinds of existence forms, for example ZnSO
4, Na
2SeO
3, GeO
2Deng being the inorganic states trace element.ZnSO for example
4, Na
2SeO
3, GeO
2, CrCl
3Bio-ligand complex (as germanium yeast, chromium yeast, zinc yeast etc.) and self transform by biological, promptly to generate amino-acid zinc, aminoacid selenium etc. with organic acid in the organism (as aminoacid) complexation be organic state micro element to the inorganic states trace element.
The trace element replenisher product of selling on the existing market is as " Theragran ", " Centrum " etc., and trace element wherein all is trace element of inorganic states, and the absorption of human body utilization rate is low.Trace element composition and proportioning are not prepared at the health of different crowd in these class health product, and for example common complaint among the elderly is cancer, cardiovascular diseases, diabetes, hepatitis B etc., and selenium (Se) is relevant with lacking, and needs Selenium Supplement especially; Glucose tolerance factor reduces and shortage chromium (Cr in diabetes patient's the body
3+) relevant, need to replenish chromium; Grow up healthy and sound process and zinc (Zn), lysine content such as the increasing of juvenile, intelligence is relevant, needs to replenish.
Have only single vitamin E or its health product to sell for example oral capsule, skincare product etc. now on the market.Relevant trace element health-care product are also more single.Do not make full use of trace element-selenium and germanium synergism, do not make full use of the coordinative role of selenium and vitamin E yet Human Physiology.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, characteristics at middle-aged and elderly people, a kind of middle-aged and elderly people trace element replenisher are provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, be beneficial to human body and effectively absorb.
The objective of the invention is to overcome the weak point of existing technology, characteristics at the juvenile, a kind of juvenile's organic state micro element supplement agent is provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, effectively absorb with favourable human body.
The objective of the invention is to overcome the weak point of existing technology, characteristics at the diabetes patient, a kind of diabetes patient's organic state micro element supplement agent is provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, be beneficial to human body and effectively absorb.
Middle-aged and elderly people organic state micro element supplement agent weight of the present invention is composed as follows:
Contain selenium Semen Glycines powder 10-40 part
Germanic Semen Glycines powder 10-88 part
1 part of vitamin E
Vitamin C 1-3 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
Middle-aged and elderly people organic state micro element supplement agent of the present invention uses contains selenium Semen Glycines powder, germanic Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element-selenium or germanium by the method for soilless culture.The concrete compound method that contains selenium, germanium Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step
2SeO
3Solution etc., or germanium concentration is the GeO of 50-1000 microgram/gram
2Solution etc.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, for example the cultivation case of lucifuge, cultivation box, germinating cabinet etc.
Selenium has the important physical effect to human body, is one of extremely important trace element.But its delaying human body caducity, anti-curing cancers, cardiovascular diseases, hepatic necrosis, hemolytic anemia, Keshan disease and Kaschin-Beck disease etc. also can improve people's vision, and old friend's body selenium supplement seems particularly important.
Selenium in the human body mainly depends on the Se content in the food, and it is low that low selenium area growing plants contains the Se amount, and the selenium disease just takes place to lack humans and animals easily.For example the cause of disease of Keshan disease and Kaschin-Beck disease is exactly to lack selenium, and relevant with multiple disease, as white muscle disease, exudative diathesis disease, reproductive capacity go down, disease such as digestive function obstacle.Take the photograph the selenium amount every day when human body and be lower than 22 micrograms, also can cause scarce selenium.
Trace element germanium has the function of enhancing immunity and resistance, anticancer, defying age and the multiple disease of treatment.There are some researches show that per day for adults is on average taken in the germanium of 0.4～3.7mg, can promote health, regulate physiological function, treatment tumor, antiinflammatory, antibiotic etc.A lot of germanium compounds are biologically active all, wherein especially with natural organic germanium, single organic germanium sesquioxide and sulfide and GeO
2Some bio-ligand complex (as germanium yeast) etc. higher nutritive value is arranged.
Selenium and germanium exist synergism on physiological function.Selenium and germanium all have different physiological roles, they to improve immunity, antioxidation, aspect such as anticancer plays an important role.Selenium-germanium mixed liquor is in the effect that promotes immunologic function, antioxidation, aspect such as anticancer, and the effect of using separately than selenium, germanium is bigger.Aspect the removing living radical, selenium and germanium also exist synergism; Germanium also has the selenic toxic action of antagonism.
There are following rapport in selenium and vitamin E biologically: selenium is a kind of strong oxidizer, and its effect is similar to vitamin E, but effectiveness is bigger, and is higher approximately 500 times than vitamin E as the oxidation resistance of selenoprotein.Selenium is to work by glutathion peroxidase (GSH-Px), is present in the cytoplasm, works to remove the peroxide that has formed.Vitamin E mainly is positioned on the biomembrane, by the blocking-up radical chain reaction, attacks with the membranous free radical of avoiding of protection cell membrane system.
Because the antioxidation point of Se and vitamin E is different, though both have many similarities aspect anti-oxidative damage, can show as both and play complementary action, even lack that either party is inoperative also showing aspect certain, only when The combined, just can give full play to the effect of the anti-damage of antioxidation.
Juvenile's organic state micro element supplement agent weight of the present invention is composed as follows:
Contain zinc Semen Glycines powder 30-50 part
Contain selenium Semen Glycines powder 10-40 part
Germanic Semen Glycines powder 10-88 part
Vitamin C 1-3 part
1 part of vitamin E
L-lysine 10-20 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
The present invention uses contains selenium Semen Glycines powder, germanic Semen Glycines powder, contain the zinc Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element-selenium or germanium or zinc by the method for soilless culture.Contain selenium, concrete preparation method germanic, that contain the zinc Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step
2SeO
3Solution; Or germanium concentration is the GeO of 50-1000 microgram/gram
2Solution, or zinc concentration is the solution of zinc sulfate of 800-4000 microgram/gram etc.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, for example the cultivation case of lucifuge, cultivation box, germinating cabinet etc.
Zinc (Zn) plays immeasurable effect in life process, be described as " Promethean fire flower ".Many researchs point out that the effect of zinc and juvenile's height is most important, are to influence the excretory important element of human growth hormone.It directly acts on hypophysis cerebri, can reasonably activate, and adjusts secretion of growth hormone, synthetic and release, promote the human body metabolism, accelerate cell division and regeneration, make the regeneration of shank skeletal cartilage, carrtilage space increases, manyly absorb skeleton nutrition quickly, reach the purpose that increases.Even under the situation that cartilage has healed, secretion that still can the stimulating growth hormone makes brain skeletal cartilage regeneration slit, absorbs nutrition once more, reaches the effect that increases once more.Zinc has many-sided physiological function, zinc deficiency will influence that the metabolism that the proper splitting of cell and immune function depression, protein synthesis produce obstacle, endocrine disturbance, cell slows down, resistance weakens, individual senescence process is accelerated, and can be caused cancer morbidity to increase.
L-lysine is one of proteinic important component part, it is the indispensable food additive of human body, be referred to as meaning " aminoacid that nutrition is necessary " by scientist, it can health invigorating, promote intelligence development, increase child's height, but and vessel softening, preventing multiple functions such as cerebral hemorrhage, is the nutrition treasure that the world today generally acknowledges.
Diabetes patient's organic state micro element supplement agent of the present invention is composed as follows:
Contain 1 part of chromium Semen Glycines powder
Contain vanadium Semen Glycines powder 0.8-3.2 part
Contain lithium Semen Glycines powder 5.3-10.7 part
Contain selenium Semen Glycines powder 6.7-26.7 part
Contain zinc Semen Glycines powder 22.2-33.3 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
The present invention uses contains chromium, contain vanadium, contain lithium, contain selenium, contain the zinc Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element chromium, vanadium, lithium, selenium, zinc by the method for soilless culture.The concrete preparation method that contains selenium, germanium Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step
2SeO
3Solution etc.; Or germanium concentration is the GeO of 50-1000 microgram/gram
2Solution or zinc concentration are that solution of zinc sulfate of 600-4000 microgram/gram etc. or concentration are the CrCl of 50-1000 microgram/gram
3Solution etc., or concentration is the lithium carbonate solution of 50-200 microgram/gram etc., or concentration is sodium metavanadate, sodium vanadate solution of 50-500 microgram/gram etc.Above-mentioned solution can be separately or two kinds of solution mix and use.
Above-mentioned various microelement nutritious liquid is self transformation by these bean kinds, closes with its intravital organic acid (as aminoacid) chromium, generates various organic chromium compounds---the active substance of life, promptly helps the trace element of absorption of human body and utilization.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, for example the cultivation case of lucifuge, cultivation box, germinating cabinet etc.
Chromium (Cr
3+) be the active component of glucose tolerance factor, chromium exists with three valence states in vivo, and chromic main effect is the metabolism of involved in sugar and fat, and the chromic content of diabetics blood plasma is starkly lower than the normal person, and patient's blood glucose is reduced; To blood glucose person on the low side, blood glucose is risen.Trivalent chromium is harmless in vivo.
Lithium (Li) can promote various tissue picked-up sugar and store glycogen, humans and animals is all had antidiabetic effect.Treat the diabetes result of the test with lithium: 1. blood glucose, glucose in urine all reduce; 2. plasma insulin, C peptide concentration all descend; 3. the Insulin receptor INSR number of high and low affinity all increases on the erythrocyte, and lithium performance blood sugar reducing function is described.Result of study shows that also lithium can also promote the dna replication dna of insulin B cell.Lithium carbonate is one for the treatment of diabetes ancillary drug commonly used, and the adult is 200-400 μ g/d to the day requirement of lithium.
Vanadium (V) not only participates in human body hemopoietic in human body, also influence cholesterol metabolism.Recently studies show that vanadium has ILA, vanadate reduces the blood glucose value of rising.The blood sugar reducing function of vanadium is relevant with combined state, and the adult is 40 μ g/d to the day requirement of vanadium.Confirm that at present sodium metavanadate, sodium vanadate, vanadium oxysulfate, vanadic anhydride etc. all have blood sugar reducing function.
The dependency that has height between diabetes and the selenium.Selenic metabolism disorder in the diabetics body.Selenium also is the active center material of glutathion peroxidase (GSH-Px).The relation of selenium and diabetes receives publicity recently.Recently selenic result of study is found: type ii diabetes does not have complication group and the no significant difference of health group contrast, and type ii diabetes has complication group and health to organize and do not have the contrast of complication group, and highly significant difference is all arranged.Prompting is to the suitable selenium supplement of type ii diabetes person that complication is arranged.
At present, known in human body have at least the activity of 80 plurality of enzymes all relevant with zinc.Enzyme is a biocatalyzer, because zinc energy kinase, so promote the metabolism of sugar.Pancreas is one of the most responsive organ of zinc metabolism, and insulin is that the form with crystalline state or subgrain attitude zinc is present in the secreting gland of pancreas.Lacking zinc is the major reason that insulin concentration reduces.Usually the content of zinc (Zn) is lower than the normal person among diabetes blood glucose's (or hair), illustrates that the diabetes patient needs zinc supplement.
The used beans of the present invention can be Semen Glycines, Semen phaseoli radiati, Semen sojae atricolor, Semen Phaseoli, Semen Pisi sativi, Seem Lablab Album etc.
Organic state micro element supplement agent of the present invention can be made dosage forms such as electuary, concentrated solution, capsule.
As seen organic trace nutrient supplement of the present invention mainly be among the current crowd often because of lacking nutrient in the food, can not satisfy the health needs and cause body immunity decline, vulnerable, easy aging, easily fall ill and the new product released.It is divided into middle-aged and elderly people organic state micro element supplement agent, juvenile's organic state micro element supplement agent, diabetes patient's organic state micro element supplement agent according to different age people and nutritional deficiency disease situation.
Technical conceive of the present invention is an applying biological geochemistry food engineering scientific method, utilize above-mentioned various needed by human or beneficial trace elements optimize beans, improve little nutrient composition content level of these beans and be primary raw material, add an amount of vitamin E, Vc etc. with these rich plain Semen Glycines powderes.By human body the daily requirement of various trace element is carried out scientific matching.
The adult is as follows to the daily requirement of trace element, vitamin: chromium 50-200 μ g/d; Lithium 200-400 μ g/d; Vanadium 40 μ g/d; Selenium 50-200g/d; Germanium 0.4-3.5mg/d; Zinc 10-15mg/d; Vitamin E 50-150mg/d; Vitamin C 100-300mg/d; Lysine 1-2g/d (children).
The present invention compared with prior art has following advantage:
1, used base stock-contain trace element beans powder is the biological product of pure natural.The trace element that is rich in the beans is sheerly natural, the bioactive organic complex of tool.It is an applying biological geochemistry food engineering scientific method, utilize biological (beans) as the carrier that transmits micro elements needed by human, promptly, the trace element of artificial input is organised, become the active substance that is easy to the absorption of human body utilization by the transformation of beans self.
2, trace element lives through great several times improvement as the development and use of nutrient source for a long time substantially, promptly by the product that directly utilizes inorganic salt (as zinc sulfate etc.) to make.As (the belonging to first generation nutrient) such as " Centrum " of agent of sulfated compound zinc metal sheet and current market sale; With the product of simple organic acid and inorganic salt chemosynthesis, as (the belonging to second filial generation trace nutrient) such as zinc gluconate of current market sale; The product that utilizes biogenic aminoacid and trace element complexation (or chelating) to make belongs to third generation nutrient, also is the nutrient of latest generation.The latter overcomes poor, the instability of preceding two generation product bio-absorbable usability, easily oxidation, easily has shortcomings such as closely questioning anti-effect between element between the moisture absorption and inorganic salt product.
Organic state micro element supplement agent of the present invention is the third generation that belongs to above-mentioned, i.e. Xin Yidai product.Its advantage is the bioavailability that has improved trace element greatly, and anti-interference, good stability, toxicity are little, are the effective little nutrients of a kind of safety and stability.
3, the preparation of organic state micro element supplement agent of the present invention is the rapport that makes full use of between trace element, makes the bigger effect of they performances, as the rapport between trace element-selenium and the germanium; Rapport between rapport between trace element-selenium and the vitamin E and vitamin E and the vitamin C etc.And have only single vitamin E or its health product to sell (as oral capsule, skincare product etc.) or inorganic states trace element replenisher on the current market.Middle-aged and elderly people organic state micro element supplement agent of the present invention is exactly to make full use of the new product that trace element-selenium is used with cooperating of vitamin E and the rapport of selenium and germanium is developed; Also make full use of simultaneously and other nutritional labelings between rapport, as trace element zinc and L-lysine and macroelement calcium to the juvenile increase, intelligence development all is considerable nutrient substance, therefore, in juvenile's organic state micro element supplement agent of the present invention, all these nutrient substance are taken into account.
Also have in the diabetes medicament and health product of current market sale, utilize trace element few for medicine and health product that the diabetes patient uses specially, what have just makes an addition in the milk powder with Chlorizate chromium.Diabetes patient's organic state micro element supplement agent of the present invention is the cause effect relation at trace nutrient and diabetes, utilizes the trace element relevant with developing various diabetes more all sidedly.
The specific embodiment
Below by embodiment the present invention is done further narration.
Diabetes patient's organic state micro element supplement agent
(1) contains chromium (Cr
3+), the preparation of lithium, vanadium, zinc and selenium Semen Glycines powder: with chromium chloride solution (Cr
3+Concentration is 1000 μ g/g), lithium carbonate solution (Li concentration is 400 μ g/g), sodium metavanadate (concentration of V is 200 μ g/g), sodium selenite (Se concentration is 75 μ g/g) and solution of zinc sulfate (Zn concentration is 4000 μ g/g) optimize the Semen Glycines seed respectively.Can obtain containing Cr
3+The analysis for soybean powder of 800 μ g/g, Li250 μ g/g, V100 μ g/g, Se50 μ g/g, Ge400 μ g/g, Zn3000 μ g/g.
(2) prescription is formed: contain chromium Semen Glycines powder 10g; Contain lithium Semen Glycines powder 10g; Contain vanadium Semen Glycines powder 2.5g; Contain zinc Semen Glycines powder 20g; Contain selenium, germanium Semen Glycines powder 10g.Make capsule, every 0.6g allows 60 years old diabetes patient, and 3/day, 3 times/day, 3/time.The state of an illness is alleviated after 1 month, and blood glucose reduces.
Claims (1)
1, a kind of organic state micro element supplement agent is characterized in that weight is composed as follows:
Contain 1 part of chromium Semen Glycines powder
Contain vanadium Semen Glycines powder 0.8-3.2 part
Contain lithium Semen Glycines powder 5.3-10.7 part
Contain selenium Semen Glycines powder 6.7-26.7 part
Contain zinc Semen Glycines powder 22.2-33.3 part
Its preparation method comprises the steps:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water; The used nutritional solution that contains trace element of seed soaking is that selenium concentration is the Na of 50-100 microgram/gram in the first step
2SeO
3Solution; Or zinc concentration is that the solution of zinc sulfate or the concentration of 600-4000 microgram/gram is the CrCl of 50-1000 microgram/gram
3Solution; Or concentration is the lithium carbonate solution of 50-200 microgram/gram or sodium metavanadate, the sodium vanadate solution that concentration is 50-500 microgram/gram, above-mentioned solution can be separately or two kinds of solution mix and use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021283397A CN1203878C (en) | 1999-12-30 | 1999-12-30 | Organic state micro element supplement agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021283397A CN1203878C (en) | 1999-12-30 | 1999-12-30 | Organic state micro element supplement agent |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99124691A Division CN1112214C (en) | 1999-07-20 | 1999-12-30 | Organic trace elements supplement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1491672A true CN1491672A (en) | 2004-04-28 |
| CN1203878C CN1203878C (en) | 2005-06-01 |
Family
ID=34231246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021283397A Expired - Fee Related CN1203878C (en) | 1999-12-30 | 1999-12-30 | Organic state micro element supplement agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1203878C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209107B (en) * | 2007-12-24 | 2011-08-17 | 秋生堂生物科技（北京）有限公司 | Method for preparing high protein edible material containing vanadium |
| CN104351660A (en) * | 2014-11-17 | 2015-02-18 | 江苏瑞谷安隆生态农业科技有限公司 | Preparation method of high-gamma-aminobutyric acid germinated brown rice and selenium-enriched germinated brown rice |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381073C (en) * | 2005-09-07 | 2008-04-16 | 韶关学院 | A kind of rich propolis and its application |
-
1999
- 1999-12-30 CN CNB021283397A patent/CN1203878C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209107B (en) * | 2007-12-24 | 2011-08-17 | 秋生堂生物科技（北京）有限公司 | Method for preparing high protein edible material containing vanadium |
| CN104351660A (en) * | 2014-11-17 | 2015-02-18 | 江苏瑞谷安隆生态农业科技有限公司 | Preparation method of high-gamma-aminobutyric acid germinated brown rice and selenium-enriched germinated brown rice |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1203878C (en) | 2005-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105052533B (en) | A kind of implantation methods of the Poria cocos of Rich in Trace Element | |
| CN102793163A (en) | Calcium-iron-zinc-selenium multivitamin chewable tablet and preparation method thereof | |
| CN101366451A (en) | Feedstuff additive for improving oil and fat assimilation utilization ratio and preparation method thereof | |
| CN104663246A (en) | Production method of edible mushroom with rich selenium and high calcium | |
| CN104920053A (en) | Method for planting microelement-enriched cistanche | |
| CN104920054A (en) | Method for planting microelement-enriched ginseng | |
| CN101690591A (en) | Yak marrow polypeptide bone growing and height increasing tablets (powder) | |
| CN1203878C (en) | Organic state micro element supplement agent | |
| CN103262980A (en) | Selenium germanium chromium elements-enriched vitamin spirulina health-care rice flour | |
| CN105707901A (en) | Activated selenium and production method thereof | |
| CN105198638A (en) | Cultivation method of selenium-rich high-calcium edible mushrooms | |
| CN104256818A (en) | Method for producing natural zinc-rich bamboo juice | |
| CN1112214C (en) | Organic trace elements supplement | |
| CN103330118A (en) | Antiobesity drug | |
| CN1118243C (en) | Nutritive soybean-pumpkin powder | |
| CN103005211A (en) | Application of calcium-chitosan organic calcium supplement to animal feed | |
| CN1198902A (en) | Nutriment for pregnant women and parturient women and its production process | |
| CN106561368A (en) | Planting method of high-tin, germanium and strontium rice | |
| CN110235990A (en) | It is a kind of to adjust pigeon racing and circle in the air the composition of physical efficiency | |
| CN1711856A (en) | Fe contained yoghurt sheets for treating anemia | |
| CN108689768A (en) | A kind of high yield mixed fertilizer of selenium-rich richness germanium | |
| CN101258935A (en) | Health-care spirulina food | |
| RU2475050C2 (en) | "protobiol" substances composition for impact on microbial-tissular complex of human bowel and method for microbial-tissular complex recovery in general | |
| CN112914109B (en) | Preparation method and application of peptide nano-selenium | |
| JP2000166583A (en) | Inorganic compound produced by bacillus subtilis or the like, its acid salt, by-product and derivative thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |