CN1424126A - Method for quickly extracting out solutes in porous media - Google Patents
Method for quickly extracting out solutes in porous media Download PDFInfo
- Publication number
- CN1424126A CN1424126A CN 02159934 CN02159934A CN1424126A CN 1424126 A CN1424126 A CN 1424126A CN 02159934 CN02159934 CN 02159934 CN 02159934 A CN02159934 A CN 02159934A CN 1424126 A CN1424126 A CN 1424126A
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- Prior art keywords
- leaching
- solvent
- porous media
- solutes
- porous
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- 238000000034 method Methods 0.000 title claims abstract description 31
- 239000002904 solvent Substances 0.000 claims abstract description 53
- 238000002386 leaching Methods 0.000 claims abstract description 45
- 230000008961 swelling Effects 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 7
- 238000012546 transfer Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000004090 dissolution Methods 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- BQFCCCIRTOLPEF-UHFFFAOYSA-N chembl1976978 Chemical compound CC1=CC=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 BQFCCCIRTOLPEF-UHFFFAOYSA-N 0.000 description 8
- 238000011084 recovery Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 241000219061 Rheum Species 0.000 description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 2
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 2
- 150000004056 anthraquinones Chemical class 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Landscapes
- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
用于多孔介质中溶质快速浸出的浸取方法，涉及利用互溶溶剂间的溶解效应引起的微对流来加强多孔介质中质量传递的浸取方法。该方法选择对溶质均具有较好溶解能力的浸取溶剂A及其互溶溶剂B，首先采用少量B使多孔介质达到溶胀饱和，然后通过追加A或其他方式将多孔介质的外部溶剂切换为A并进行浸出。该发明具有浸取速度快、收率高、条件温和、选择性强、费用低、易于实施的优点，特别适用于以多组分提取物为目标的植物药材及其它天然资源的浸取，是一种高效、新型的多孔材料内部传质强化技术。
The leaching method for rapid leaching of solutes in porous media involves the use of micro-convection caused by the dissolution effect between mutual solvents to enhance mass transfer in porous media. In this method, the leaching solvent A and its miscible solvent B, which have good solubility for solutes, are selected. Firstly, a small amount of B is used to make the porous medium reach swelling saturation, and then the external solvent of the porous medium is switched to A by adding A or other methods. Leaching is performed. The invention has the advantages of fast leaching speed, high yield, mild conditions, strong selectivity, low cost, and easy implementation, and is especially suitable for leaching of plant medicinal materials and other natural resources targeting multi-component extracts. A high-efficiency and new technology for enhancing mass transfer in porous materials.
Description
Technical field
The invention belongs to chemical mass transfer separation technology field, the microconvection that particularly utilizes the solubility effect between mutual solvents to cause is strengthened the leaching method that quality is transmitted in the porous media.
Background technology
Porous media is meant that inside contains the solid material of many small holes.Many materials of occurring in nature all have loose structure, such as soil, timber, vegetable drug and mineral etc.Along with popularizing and in-depth to the natural reproducible resource development and utilization, extraction as the Chinese medicine effective ingredient, particularly the needed energy of people and resource will come from natural porous material more and more, and development is applicable to that the efficient leaching method fast of porous media is of universal significance.
The principal element that influences the transmission of porous media quality is microcellular structure and the character of the fluid in the hole and the interaction between them of material.The existence of skeleton structure can not be strengthened the quality transfer behavior in the porous material by general method.The main at present method that adopts has two classes: a kind of is the method that reduces the macro-size of porous media, this method can suitably reduce the resistance to mass tranfer in the duct, but can not be from changing in the duct mode that flows in essence, and the size of material reduces to increase the difficulty of Separation of Solid and Liquid; Another kind is the method that applies the stronger outfield of penetration power, and as ultrasonic wave and microwave etc., these outfields can cause the activation and the disturbance of the solvent and the solute molecule of porous media inside.More than two kinds of methods can reach the purpose that improves the valuable constituent leaching efficiency, but also have the leaching that can increase invalid components (impurity), bring difficulty for the separation and purification in downstream; The fuel factor that the outfield causes can be destroyed temperature sensitive property solute, preliminary treatment cost height or process and amplify problems such as difficulty.Therefore, the method for development leaching reinforcement is extremely necessary.
Summary of the invention
The purpose of this invention is to provide a kind of leaching method that the porous media solute leaches fast that is used for, promptly utilize the interaction between solvent preferably of mutual solubility property to strengthen the leaching method that solute transmits in the porous media, this method has not only that leaching speed is fast, yield is high, and mild condition, expense are low, easy to implement.
Technical scheme of the present invention is as follows: be used for the leaching method that the porous media solute leaches fast, it is characterized in that this method comprises the steps:
(1) selects extracting solvent A and dissolve each other with A or be soluble in A and can dissolve the secondary solvent B of solute in the porous media;
(2) in porous media, add earlier secondary solvent B, and be retained to porous media reach swelling saturated till;
(3) the porous media external solvent is switched to A, leach.
Described extracting solvent A or secondary solvent B are the mixed solutions of a kind of solvent or several solvents.
Switching mode described in the step of the present invention (3) has two kinds: a kind of is directly to append solvent orange 2 A in container; Another kind is earlier with filtering or centrifugal mode adds solvent orange 2 A after will being in the solvent B removal of porous media outside again.
Porous media of the present invention mainly comprises the particle that natural economic plants, tcm and herbal slice and they obtain after roughing, requiring does not have chemical bond closely between solute and matrix.
Principle of the present invention is: one, the phase counterdiffusion meeting of the inside and outside solvent of porous media drives solute migration; Two, the course of dissolution between solvent makes and forms between two parts main body solvent by forming unstable solvent turbulence district of causing, and this regional solute transmission is the convection current diffusion.
The present invention compared with prior art, have the following advantages and the high-lighting effect: the present invention is applied to the leaching of solute in the porous media, it is fast to have leaching speed, leaches fully characteristics that are easy to realize, and can implementing under room temperature or the temperature near room temperature.Switch the requirement of method to porous media itself itself and internal and external environment based on solvent, the present invention is very suitable for leaching the medicinal plant that the active ingredient in the natural plants, particularly target are the multicomponent extract.Utilize the present invention, the effective mass tranfer coefficient in the porous media duct can be by 10
-9m
2/ s rises to 10
-7m
2/ s, the effective diffusion cofficient in the fine and close hole wall also can have the raising of 1～2 order of magnitude.
Description of drawings
Fig. 1 is a principle schematic of the present invention.
Fig. 2 implements schematic diagram of the present invention for adopting the solvent additional method.
The specific embodiment
Further specify the present invention below in conjunction with drawings and Examples.
The present invention can implement in static or dynamic mode under normal pressure, and implementation step comprises:
(1) according to porous media and wherein the physicochemical properties of solute determine extracting solvent A, select to dissolve each other or be soluble in A and can dissolve the secondary solvent B of solute among the porous media C with A;
(2) adding secondary solvent B is saturated to reaching swelling in porous media C;
(3) external solvent with porous media C switches to extracting solvent A, leaches.
Wherein, select the standard of secondary solvent B to be:
A.B is soluble in A or can be miscible with A.
B.B is the good solvent of main valuable constituent among the porous media C.
C.A is very fast to the course of dissolution of B.
Implementation process is described:
Porous media material C is placed in the container, add B and be retained to porous media C reach swelling saturated till.
The external solvent B of porous media C is switched to A two kinds of optional modes are arranged.
Mode 1: in container, directly append A.
Mode 2: earlier with filtering or centrifugal mode adds A after will being in the B removal of porous media outside again.
Handoff procedure had no special requirements for the time, allowed to finish as early as possible in the scope of equipment permission.
Mode 1 also can realize by dynamic mode: porous media C is placed fixed-bed type leacher (as percolation filter), make B slowly pass through bed according to certain orientation, switch to A quarter in due course and get final product.
Said process can carry out in room temperature or under near the temperature of room temperature.
Embodiment:
(1) with the acid chromium blue k is the solute tracer of holding concurrently, solvent B is water or methyl alcohol, consumption 0.4mL, extracting solvent A adopts methyl alcohol, acetone, ethanol or water respectively, consumption 20mL, B is full of the capillary of 20 internal diameter 0.5mm,, adds the mode of solvent orange 2 A after the switching mode of solvent adopts the solvent B with the outside to remove again with the solute in the A leaching capillary.
Experimental result is as shown in the table:
| Solvent orange 2 A | Initial concentration Ppm | Solvent B | Mass transfer time S | Main body concentration ppm | Effective diffusion cofficient, D eff????m 2/s |
| Water | ??1750 | Water | ??300 | ??0.464 | ????5.00×10 -9 |
| Methyl alcohol | ??1750 | Methyl alcohol | ??120 | ??0.518 | ????1.55×10 -8 |
| Ethanol | ??1750 | Water | ??60 | ??2.840 | ????9.00×10 -7 |
| Methyl alcohol | ??1750 | Water | ??60 | ??1.850 | ????3.85×10 -7 |
| Acetone | ??1750 | Water | ??60 | ??2.630 | ????7.70×10 -7 |
Can see that by table use the leaching velocity that the present invention can accelerate solute effectively, effective diffusion cofficient improves greatly.
(2) with the Chinese herb rhubarb be object, dried medicinal material consumption 1.0g, general anthraquinone is for investigating solute, and solvent orange 2 A is a water, and consumption 200mL, solvent B are ethanol, 60 ℃ of leaching temperatures, the switching mode of solvent adopts the mode of directly appending solvent orange 2 A.Experimental result sees the following form.
| Directly leaching | Solvent switches | ||||
| Leaching time min | Leachate concentration ppm | Recovery rate 100 * g/g | Leaching time min | Leachate concentration ppm | Recovery rate 100 * g/g |
| ????1 | ??27.5 | ????0.55 | ????1 | ??31.6 | ????0.63 |
| ????2 | ??36.5 | ????0.73 | ????2 | ??37.4 | ????0.75 |
| ????6 | ??46.5 | ????0.93 | ????8 | ??52.8 | ????1.06 |
| ????16 | ??55 | ????1.1 | ????16 | ??63.2 | ????1.26 |
| ????32 | ??58.5 | ????1.17 | ????32 | ??65.2 | ????1.30 |
| ????64 | ??61 | ????1.22 | ????64 | ??63.4 | ????1.27 |
| ????120 | ??61.5 | ????1.23 | ????120 | ??71.8 | ????1.44 |
Can see by table, use the present invention when reaching same recovery rate required time short, the recovery rate height in the identical time.
(3) with the Chinese herb rhubarb be object, dried medicinal material consumption 1.0g, general anthraquinone is for investigating solute, and solvent orange 2 A is an ethanol, and consumption 200mL, solvent B are water, and 60 ℃ of leaching temperatures add the mode of solvent orange 2 A again after the switching mode of solvent adopts the solvent B with the outside to remove.Experimental result sees the following form.
| Directly leaching | Solvent switches | ||||
| Leaching time min | Leachate concentration ppm | Recovery rate 100 * g/g | Leaching time min | Leachate concentration Ppm | Recovery rate 100 * g/g |
| ????1 | ??23.5 | ????0.47 | ????1 | ??40.0 | ????0.8 |
| ????8 | ??28.0 | ????0.56 | ????2 | ??52.5 | ????1.05 |
| ????16 | ??35.5 | ????0.71 | ????4 | ??103.0 | ????2.06 |
| ????32 | ??39.5 | ????0.79 | ????16 | ??106.5 | ????2.13 |
| ????64 | ??49.5 | ????0.99 | ????32 | ??102.5 | ????2.05 |
| ????120 | ??54.5 | ????1.09 | ????120 | ??110.0 | ????2.2 |
Can be seen that by table the recovery rate when using 2min of the present invention is suitable when directly leaching 120min, strengthening effect is obvious.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021599343A CN1171654C (en) | 2002-12-30 | 2002-12-30 | Leaching method for rapid leaching of solutes in porous media |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021599343A CN1171654C (en) | 2002-12-30 | 2002-12-30 | Leaching method for rapid leaching of solutes in porous media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1424126A true CN1424126A (en) | 2003-06-18 |
| CN1171654C CN1171654C (en) | 2004-10-20 |
Family
ID=4753362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021599343A Expired - Fee Related CN1171654C (en) | 2002-12-30 | 2002-12-30 | Leaching method for rapid leaching of solutes in porous media |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1171654C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271212A (en) * | 2012-02-02 | 2015-01-07 | 绿色能源有限公司 | Methods for recovering and/or removing reagents from porous media |
-
2002
- 2002-12-30 CN CNB021599343A patent/CN1171654C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271212A (en) * | 2012-02-02 | 2015-01-07 | 绿色能源有限公司 | Methods for recovering and/or removing reagents from porous media |
| US9181490B2 (en) | 2012-02-02 | 2015-11-10 | Green Source Holdings Llc | Methods for recovering and/or removing reagents from porous media |
| US9464236B2 (en) | 2012-02-02 | 2016-10-11 | Green Source Holdings Llc | Compositions and methods for recovering and/or removing reagents from porous media |
| CN104271212B (en) * | 2012-02-02 | 2017-03-29 | 绿色能源有限公司 | For the method for reclaiming from permeability medium and/or remove reagent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1171654C (en) | 2004-10-20 |
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