CN1423961A - Chitin healthy food and production thereof - Google Patents
Chitin healthy food and production thereof Download PDFInfo
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- CN1423961A CN1423961A CN02157749A CN02157749A CN1423961A CN 1423961 A CN1423961 A CN 1423961A CN 02157749 A CN02157749 A CN 02157749A CN 02157749 A CN02157749 A CN 02157749A CN 1423961 A CN1423961 A CN 1423961A
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Abstract
A health-care chitosan food in the form of capsule, chewing tablet or tablet for regulating blood fat, improving immunity, lossing weight and detoxicating is mainly prepared from chitosan, N-acetyl-D-aminoglucose, VC and citric acid. Its additives may be milk powder, magneisum stearate, beta-cyclodextrin, etc.
Description
Technical Field
The invention relates to chitosan capsules, chewable tablets and tablets for regulating blood fat, enhancing immunity, losing weight, expelling toxin and the like and a preparation method thereof.
Background
Because the quality of life of China is improved, the dietary structure is changed, and the elderly population is growing at a rate of 3% per year, the morbidity and mortality of various diseases such as hyperlipidemia, atherosclerosis, coronary heart disease, hypertension, cerebral apoplexy and the like are increased year by year, and cardiovascular and cerebrovascular diseases become the first killer threatening the life health of human beings. With the improvement of living standard, people pay more and more attention to the improvement of living quality, and especially the prevention and treatment of various seriously harmful diseases are improved to a quite important position.
On the other hand, obesity has become a current global epidemic, and the prevalence of obesity in china is rapidly increasing. Experts predict that the obese population of Chinese may exceed two hundred million in the next 10 years. Obesity is accompanied with cardiovascular diseases, hypertension, hyperlipidemia, diabetes and other diseases, so that the threat to human health is increased, and the obesity becomes a current medical problem. The risk of obesity complications is increased along with the rise of body weight index, the relative risk of obesity patients to have II-type diabetes is more than 3 times of that of common people, and the risk of obesity patients to suffer from coronary heart disease is 2 to 3 times of that of common people. Obesity is an independent risk factor of cardiovascular diseases, and has more significant advantages than blood pressure, smoking or sugar tolerance in the aspect of predicting coronary heart disease. Obesity also increases the risk of developing cancer, digestive, respiratory and osteoarthrosis, and obesity can lead to hypertension, which can also lead to cerebrovascular disease and is the most dangerous factor for the development of cerebrovascular disease. Although excessive dietary fat intake is an important cause of obesity, it is difficult for people with excessive weight to successfully lose weight by diet alone.
Chitosan is the only positively charged natural animal fiber in nature, which was found as early as 1811 by the french scholar (Braconno), and was proposed in 1823 by the european gill (Odier) from the crustacean shell and named CHITIN, translation name CHITIN. In 1894, Hoppe-Seyler named deacetylated chitin Chitosan, i.e., CHITOSAN. In 1977 the first world-wide CHITOSAN academic exchange was held in the United states, which was since then spotlighted to expand another new product era in human history. In 1990, researchers at the university of Hokkaido, Japan, and the university of pretty, have theories of preventing cancer and inhibiting cancer cell metastasis, and preventing blood pressure from rising, etc. and have become topics of medical booming, chitosan is the only functional health food which has been allowed by the Japanese government so far and can promote the curative effect. In 1991, the medical science and science community, university and nutritional food research institution in the United states and Europe praise the sixth vital element of human body after sugar, protein, fat, vitamins and minerals (inorganic salts). Chitosan production was approved by the united states drug food administration (FDA) and european community government (EC) in 1995.
Because chitosan is a positively charged cationic compound, it accumulates around negatively charged lipid droplets in vivo to form a barrier that hinders fat absorption, and it can also bind bile acids to affect lipid emulsification and reduce its absorption. The chitosan has cholesterol conversion promoting effect. Cholesterol is converted in the liver into bile acids, which are important components of digestive fluids and are stored in the gallbladder in certain amounts, and the bile acids are usually reabsorbed back to the liver by the small intestine after completing the digestion and absorption of fat, which is the "enterohepatic circulation" of bile acids. Since chitosan is easily combined with bile acid and is completely excreted, it is necessary to convert cholesterol into bile acid in the liver in order to maintain a normal level of bile acid, with the result that the cholesterol level in blood is necessarily reduced, and there is also a significant weight loss function.
Modern mankind enters the chitin-deficient era. Before the 50 s in the 20 th century, people can generally eat chitin, and sufficient chitin can be absorbed only by eating coarse cereals, fruits and vegetables. This period is the original unconscious chitin intake period from natural food for humans, as it were. However, the pollution of air, water source and food, the use of a large amount of pesticides and chemical fertilizers, the popularization of mulching films, greenhouses and soilless culture methods can lead insects to disappear in a large amount, the normal food chain is damaged, and the human beings have entered the era of lack of chitin in vivo. The lack of chitin and its derivatives can cause a series of diseases, such as cardiovascular and cerebrovascular diseases, tumors, diabetes, physiological dysfunction, etc. In order to treat these diseases, people are also producing renovating medicines like increasing pesticides and fertilizers to plants, however, the modern medicines do not have expected effects which people imagine. The medical expert warned that people must consciously supplement chitin like the edible iodized salt to strengthen our health.
The main functions of chitosan are as follows:
1. absorb fat components, reduce fat residue, and effectively reduce weight.
2.Stimulating and strengthening the immunity of the human body, resisting fatigue and aging.
3. Endotoxin, pesticide, heavy metal, chemical pigment and radioactive rays are absorbed and discharged out of the body.
4. Strengthening liver function, and inhibiting liver cancer. Has good effect on alcoholic hepatitis, fatty liver and liver cirrhosis.
5. Removing harmful cholesterol, and preventing and treating arteriosclerosis, hypertension, and cerebral apoplexy.
6. Resisting cancer, and inhibiting metastasis of cancer cells.
7. Inhibiting blood sugar increase, and improving diabetes.
8. Promoting intestinal beneficial bacteria, promoting intestinal motility, and relieving constipation.
9. Treating burn and scald, and accelerating wound healing.
10. Promoting secretion of hormone, enhancing vitality, restoring youth, and caring skin.
N-acetyl-D-glucosamine is present in breast milk and is barely detectable in cow's milk. In fact, infants fed cow's milk or other artificial foods are very sick, especially sick and prone to belly or dry stools. Medical statistics also show that the incidence and mortality of artificially fed infants is higher than that of breast-fed infants. The research finds that: breast milk contains an active substance containing aminopolysaccharide and oligosaccharide, which are composed of N-acetyl-D-glucosamine, and the active substance can promote the proliferation of bifidobacteria in vivo, but can not be detected in cow milk. This is also confirmed by a number of clinical reports and basic studies.
It has been reported that bifidobacteria in the intestinal tract of breast-fed infants born for 6-8 days account for 98% of the total bacteria, whereas bifidobacteria in the intestinal tract of artificially fed infants account for only 61%, and even that no bifidobacteria were detected in the intestinal tract of artificially fed infants born for 1-3 days.
During the metabolism process, bifidobacteria produce various organic acids. Acetic acid and lactic acid, and volatile fatty acids such as propionic acid, isobutyric acid, butyric acid, isovaleric acid, etc. can be detected in the stool of breast-feeding infant. The acid has an inhibiting effect on putrefying bacteria, and the putrefying bacteria are increased because the acid can not be detected by artificially fed infants, so that the digestive tract dysfunction is caused, and intestinal diseases are caused, which is one of the important raw coal causes with high morbidity and mortality of the infants. It can be seen that bifidobacterium plays an important role in promoting the growth and development of infants, regulating nutrition, preventing infection and the like. There have been proposals by experts to use the amount of bifidobacteria in infants as an indicator of the health of the infant.
Of course, breast feeding is beneficial to infants not only by increasing bifidus factors, but also by increasing immune factors in vivo, such as immunoglobulin, and the like, so that the autoimmunity of the infants is improved, and the disease resistance is enhanced. Therefore, the world health organization and China always advocate breast feeding, and young mothers artificially feed without the trouble or the fear of influencing the body shape. When the infants are fed artificially and carelessly, the infants should be supplemented with bifidus factors properly to increase the number of bifidobacteria in the body and reduce the occurrence of disease germs. In Japan, bifidus factor has been added to infant milk replacers as a food additive.
Vitamin C is a water-soluble strong antioxidant, an excellent free radical scavenger, can protect a biological membrane from free radical attack, effectively resist aging nutrients, prevent fatty cardiovascular diseases, improve the immunity of the organism, and has the functions of keeping the function of cardiac muscle, reducing cholesterol in blood, effectively recovering fatigue and the like. More importantly, the vitamin C and the chitosan have synergistic effect on inhibiting the digestion and absorption of fat. If a large amount of chitosan and vitamin C sodium salt are continuously administered while a high fat diet is administered to SD rats, absorption of minerals such as calcium ions and fat-soluble vitamin E is inhibited while absorption of fat digestion is inhibited, and thus it is necessary to supplement certain calcium when chitosan and vitamin C are taken for a long period of time, but vitamin E absorption is not seen when a glucosamine monomer is administered.
Citric acid has mild, refreshing and sour taste, and is widely used for preparing various beverages, soda water, wine, candy, snack, biscuit, canned fruit juice, dairy products and other foods. In all markets of organic acids, the market share of citric acid is more than 70%, and no sour agent capable of replacing citric acid exists at present.
To date, chitosan health-care products with multiple health-care functions of regulating blood fat, enhancing immunity, losing weight, expelling toxin and the like are not seen in China.
Disclosure of Invention
The invention aims to develop chitosan compound capsules, chewable tablets and tablet products which are convenient to take and carry and have obvious and multiple health-care functions by utilizing pure natural and marine green raw materials.
The invention provides a chitosan health food, which consists of chitosan, N-acetyl-D-glucosamine, vitamin C and citric acid, wherein the capsule comprises the following components in parts by weight:
chitosan 60-80 wt%
10-35 wt% of N-acetyl-D-glucosamine
1-4 wt% of vitamin C
1-4 wt% of citric acid
The balance of auxiliary materials.
The four main materials can be directly purchased from the market, and then different auxiliary materials are added according to the requirements of the dosage form, such as: magnesium stearate, cyclodextrin, starch, and the like. The preparation method can be implemented by the conventional health food method.
In the invention, the preparation method of chitosan and N-acetyl-D-glucosamine comprises the following steps: chitin prepared from shrimp and crab and Limulus shell is soaked in NaOH water to obtain chitin amine; reacting chitin with hydrochloric acid to obtain D-glucosamine hydrochloride, and reacting the D-glucosamine hydrochloride with acetic anhydride to obtain N-7 acyl-D-glucosamine.
The invention can be directly prepared from shell raw materials such as shrimp, crab, horseshoe crab shell and the like, so that the preparation cost is reduced, namely the raw materials are prepared into chitin, and the chitin can be prepared into the chitosan by a conventional method of soaking the chitin in NaOH water, and the prior art can be implemented as follows: reacting chitin with hydrochloric acid to obtain D-glucosamine hydrochloride, and reacting the D-glucosamine hydrochloride with acetic anhydride to obtain N-acetyl-D-glucosamine. The reaction is also the prior art, but the invention respectively prepares the chitosan and the N-acetyl-D-glucosamine from the crust raw materials, adds a few processes and reduces the cost of the main materials. The specific implementation process is as follows:
1. preparation of chitin
(1) Cleaning shrimp and crab and horseshoe crab shell with water, spin-drying, removing impurities, sun-drying, metering, putting into a reaction kettle, adding 5% HCl, soaking at normal temperature for 8h, taking out, washing with water until the pH value is neutral, spin-drying, and sun-drying.
(2) Putting the dried product into a reaction kettle, adding 5% NaOH solution, heating to 105 ℃, keeping the temperature for 2h, taking out, washing with water, drying by spin-drying, and drying at 80 ℃ to obtain white chitin.
2. Preparation of chitin amine
Adding chitin into a reaction kettle, adding 50% NaOH solution, heating to 120 deg.C, maintaining the temperature for a certain time, taking out, draining, washing with water, and oven drying at 80 deg.C to obtain white chitin.
3. N-acetyl-D-glucosamine
Adding chitin and hydrochloric acid into a reaction kettle in proportion, reacting at 85 deg.C for 4h, adding active carbon, decolorizing at 70 deg.C for 0.5h, filtering, cooling, crystallizing, drying by drying, and oven drying at 80 deg.C to obtain white D-glucosamine hydrochloride; then, D-glucosamine hydrochloride and acetic anhydride are put into a reaction kettle according to a certain proportion, react for 4 hours at a low temperature, and are filtered and dried at 80 ℃ to obtain white N-acetyl-D-glucosamine.
Preparing chitosan capsules: cleaning chitosan with water, spin-drying, drying at 75-85 deg.C, pulverizing, sieving with 80-160 mesh sieve to obtain chitosan powder, adding chitosan powder, N-acetyl-D-glucosamine, vitamin C and citric acid into a mixer step by step, mixing, placing into a radiation box, irradiating for sterilization, filling into capsules under purifyingcondition, subpackaging, packaging, inspecting, and storing.
The process flow chart is as follows:
1. preparation of chitin
2. Preparation of chitin amine
3. Preparation of N-acetyl-D-glucosamine
4. Preparation of chitosan capsules
The preparation method of the chitosan health food chewable tablet comprises the following steps: washing chitosan with water, spin-drying, drying at 75-85 deg.C, pulverizing, sieving with 80-160 mesh sieve to obtain chitosan powder, adding chitosan powder, N-acetyl-D-glucosamine, vitamin C, and citric acid into a mixer step by step, adding adjuvants, mixing, placing into a radiation box, irradiating for sterilization, granulating into uniform granules, drying at 35-45 deg.C, loading into a tablet press, making into required tablet, removing irregular tablet, and packaging to obtain the final product, wherein the adjuvants are:
1-20 wt% of milk powder
Magnesium stearate 0.5-1.0 wt%
β -Cyclodextrin 1-10 wt%
And a little essence is added.
Wherein the spice can be fruit type spice, mint type spice or chocolate spice.
The preparation method of the chitosan health food tablet comprises the following steps: cleaning chitosan with water, spin-drying, drying at 75-85 ℃, crushing, sieving with a 100-plus-200-mesh sieve to obtain chitosan powder, then adding the chitosan powder, N-acetyl-D-glucosamine, vitamin C and citric acid into a mixer step by step according to the components, adding auxiliary materials, fully and uniformly mixing, placing into a radiation box for irradiation sterilization, preparing into uniform small particles through a granulator, drying at 35-45 ℃, then putting into a tablet press to prepare into a specified tablet type, removing irregular tablet type, putting into a packaging machine, and packaging to obtain a finished product, wherein the added auxiliary materials are as follows:
1-3 wt% of adhesive starch
Disintegrating agent NaHCO31-8 wt% or 2-5 wt% of sodium carboxymethyl starch
A little coating material is used.
The invention is characterized in that chitosan compound capsules, chewable tablets and tablet products have multiple health care functions of regulating blood fat, preventing atherosclerosis, protecting heart and cerebral vessels, enhancing immunity, losing weight and expelling toxin, and the like, are convenient to carry and take, are safe and effective, and have the main component of the natural animal fiber with only positive charge from the ocean. Is suitable for daily health promotion of patients with cardiovascular and cerebrovascular diseases such as hyperlipidemia, atherosclerosis, coronary heart disease, hypertension, cerebral apoplexy, obesity, and low resistance. The invention has the advantages of clear effects of all components, easy process of the preparation method, good product effect and suitability for various occasions and different people.
Detailed Description
Example 1:
a chitosan composite capsule, which is prepared by feeding 1000kg at one time. Firstly, cleaning chitosan with water, spin-drying, drying at 80 ℃, then crushing, inspecting, crushing, and sieving with a sieve of 80-160 meshes to obtain chitosan powder; putting 700kg of chitosan powder, 250kg of N-acetyl-D-glucosamine, 25kg of vitamin C and 25kg of citric acid into a mixer, mixing uniformly, and sampling to check to be qualified for later use; then the evenly mixed main material and a little auxiliary material are mixed and then irradiated for sterilization, and the capsule is filled under the purification condition. And subpackaging the capsules, packaging, sampling, inspecting and warehousing the qualified finished products.
Example 2:
a chitosan compound chewable tablet is prepared by the steps of feeding 1000 kg. in total at one time, cleaning chitosan with water, spin-drying, drying at 80 ℃, crushing after passing inspection, sieving with a sieve of 80-160 meshes to obtain chitosan powder, feeding 700kg of chitosan powder, 200kg of N-acetyl-D-glucosamine, 10kg of vitamin C and 10kg of citric acid into a mixer, uniformly mixing, sampling and inspecting for later use, fully mixing the uniformly mixed main material with auxiliary materials such as milk powder, magnesium stearate, β -cyclodextrin and essence, then placing into a radiation box for irradiation sterilization, preparing into uniform small granules through a granulator, drying at 35-45 ℃, then feeding into a tablet press to prepare into a specified tablet type, removing irregular tablet type, feeding into a packaging machine, and packaging to obtain a finished product.
Example 3:
a chitosan compound chewable tablet is prepared by feeding 1000kg at one time. Firstly, cleaning chitosan with water, spin-drying, drying at 80 ℃, then crushing, inspecting, crushing, and sieving with a sieve of 80-160 meshes to obtain chitosan powder; then putting 600kg of chitosan powder, 250kg of N-acetyl-D-glucosamine, 35kg of vitamin C and 35kg of citric acid into a mixer for uniformly mixing, and sampling and inspecting to be qualified for later use; mixing the main material with adjuvant such as adhesive (starch) and disintegrating agent (NaHCO)3Or sodium carboxymethyl starch), mixing, sterilizing by irradiation in a radiation box, granulating into uniform granules, drying at 35-45 deg.C, tabletting, coating, removing irregular tablet, packaging, and making into final product.
Claims (6)
1. A chitosan health food is composed of chitosan, N-acetyl-D-glucosamine, vitamin C and citric acid, and is characterized in that the capsule comprises the following components in percentage by weight:
chitosan 60-80 wt%
10-35 wt% of N-acetyl-D-glucosamine
1-4 wt% of vitamin C
1-4 wt% of citric acid
The balance of auxiliary materials.
2. The chitosan health food according to claim 1, wherein the chitosan and N-acetyl-D-glucosamine are prepared by the following method: chitin prepared from shrimp and crab and Limulus shell is soaked in NaOH water to obtain chitin amine; reacting chitin with hydrochloric acid to obtain D-glucosamine hydrochloride, and reacting the D-glucosamine hydrochloride with acetic anhydride to obtain N-acetyl-D-glucosamine.
3. The chitosan health food according to claim 1, wherein its capsule is prepared by the method comprising:cleaning chitosan with water, spin-drying, drying at 75-85 deg.C, pulverizing, sieving with 80-160 mesh sieve to obtain chitosan powder, adding chitosan powder, N-acetyl-D-glucosamine, vitamin C and citric acid into a mixer step by step, mixing, placing into a radiation box, irradiating for sterilization, filling into capsule under purifying condition, subpackaging, packaging, and inspecting.
4. The chitosan health food according to claim 1, wherein the preparation method of the chewable tablet comprises: washing chitosan with water, spin-drying, drying at 75-85 deg.C, pulverizing, sieving with 80-160 mesh sieve to obtain chitosan powder, adding chitosan powder, N-acetyl-D-glucosamine, vitamin C, and citric acid into a mixer step by step, adding adjuvants, mixing, placing into a radiation box, irradiating for sterilization, granulating into uniform granules, drying at 35-45 deg.C, loading into a tablet press, making into required tablet, removing irregular tablet, and packaging to obtain the final product, wherein the adjuvants are:
1-20 wt% of milk powder
Magnesium stearate 0.5-1.0 wt%
β -Cyclodextrin 1-10 wt%
And a little essence is added.
5. The chitosan health food of claim 4, wherein the flavor in the formulation is fruit-type flavor, mint-type flavor, or chocolate flavor.
6. The chitosan health food according to claim 1, wherein the preparation method of its tablet is: washing chitosan with water, spin-drying, drying at 75-85 deg.C, pulverizing, sieving with 80-160 mesh sieve to obtain chitosan powder, adding chitosan powder, N-acetyl-D-glucosamine, vitamin C, and citric acid into a mixer step by step, adding adjuvants, mixing, placing into a radiation box, irradiating for sterilization, granulating into uniform granules, drying at 35-45 deg.C, loading into a tablet press, making into required tablet, removing irregular tablet, and packaging to obtain the final product, wherein the adjuvants are:
1-3 wt% of adhesive starch
Disintegrating agent NaHCO31-8 wt% or 2-5 wt% of sodium carboxymethyl starch
A little coating material is used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02157749A CN1423961A (en) | 2002-12-26 | 2002-12-26 | Chitin healthy food and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02157749A CN1423961A (en) | 2002-12-26 | 2002-12-26 | Chitin healthy food and production thereof |
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| CN1423961A true CN1423961A (en) | 2003-06-18 |
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| CN02157749A Pending CN1423961A (en) | 2002-12-26 | 2002-12-26 | Chitin healthy food and production thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004093862A1 (en) * | 2003-04-24 | 2004-11-04 | Shin-Jen Shiao | Pharmaceutical composition comprising edible acids or the acid salts and its use |
| CN100381063C (en) * | 2005-12-19 | 2008-04-16 | 余内逊 | Preparation method of fat-reducing blood sugar-reducing sour soybean milk containing micro gingko leaf, Gymostamma pentaphyllum, haw and konnjaku powder |
| CN103096738A (en) * | 2010-05-14 | 2013-05-08 | Inq制药有限公司 | Composition for reducing absorption of dietary fat |
| CN104413328A (en) * | 2013-08-22 | 2015-03-18 | 青岛蓝农谷农产品研究开发有限公司 | Immunity enhancing health product |
| CN106072490A (en) * | 2016-06-14 | 2016-11-09 | 江苏澳新健康科技有限公司 | Compositions containing N acetyl D glucosamine and preparation method thereof |
| CN108142935A (en) * | 2018-01-24 | 2018-06-12 | 上海市第十人民医院 | A kind of slimming capsule that natural polymer subbase gel inner nuclear material is controllably constructed based on dynamic chemical key |
| CN110200284A (en) * | 2019-07-12 | 2019-09-06 | 哈尔滨工业大学 | A kind of thorn tender bud recombination chitosan blood pressure lowering chewable tablets and preparation method thereof |
-
2002
- 2002-12-26 CN CN02157749A patent/CN1423961A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004093862A1 (en) * | 2003-04-24 | 2004-11-04 | Shin-Jen Shiao | Pharmaceutical composition comprising edible acids or the acid salts and its use |
| CN100381063C (en) * | 2005-12-19 | 2008-04-16 | 余内逊 | Preparation method of fat-reducing blood sugar-reducing sour soybean milk containing micro gingko leaf, Gymostamma pentaphyllum, haw and konnjaku powder |
| CN103096738A (en) * | 2010-05-14 | 2013-05-08 | Inq制药有限公司 | Composition for reducing absorption of dietary fat |
| CN103096738B (en) * | 2010-05-14 | 2015-12-16 | Inq制药集团有限公司 | For reducing the composition of absorption of dietary fat |
| CN104413328A (en) * | 2013-08-22 | 2015-03-18 | 青岛蓝农谷农产品研究开发有限公司 | Immunity enhancing health product |
| CN106072490A (en) * | 2016-06-14 | 2016-11-09 | 江苏澳新健康科技有限公司 | Compositions containing N acetyl D glucosamine and preparation method thereof |
| CN108142935A (en) * | 2018-01-24 | 2018-06-12 | 上海市第十人民医院 | A kind of slimming capsule that natural polymer subbase gel inner nuclear material is controllably constructed based on dynamic chemical key |
| CN110200284A (en) * | 2019-07-12 | 2019-09-06 | 哈尔滨工业大学 | A kind of thorn tender bud recombination chitosan blood pressure lowering chewable tablets and preparation method thereof |
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