CN1404846A - Medicine for treating atrophic gastritis and chronic colitis and preparation method thereof - Google Patents

Abstract

The present invention relates to a medicine for curing chronic atrophic gastritis, chronic superficial gastritis and chronic colitis with good therapeutic effect. Said medicine is a capsule preparation or pill preparation made up by using 11 Chinese medicinal materials of saffron, barley sprout, Chinese yam, saussurea root, crataegus fruit and others. It possesses the advantages of simple preparation method and convenient taking method.

Description

The medicine and the preparation method of treatment atrophic gastritis and chronic colitis

Technical field

The present invention relates to a kind of medicine for the treatment of gastrointestinal disease, it is to be the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.

Background technology

The people who suffers from gastrointestinal disease is more, therefore there are many medical personnels to devote oneself to the research of this disease, cause these sick medicine listings of existing many treatments, these medicines generally all have characteristics easy to use, but they are not good enough to the therapeutic effect of atrophic gastritis and enteritis, and these medicines also have certain side effect, application number is that 95100455 patent application discloses a kind of " Chinese medicine preparation of treatment chronic colitis " for this reason, this medicament contains Radix Ginseng, the Radix Pulsatillae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Cortex Phellodendri, the Radix Astragali, Fructus Mume, Radix Puerariae, the Radix Angelicae Dahuricae, Halloysitum Rubrum, Poria, the electuary that Chinese herbal medicine such as Radix Glycyrrhizae are made, tablet, all types of medicaments such as capsule, this medicine is better to the colitis curative effect, and have no side effect, but this medicine is to gastritis, atrophic gastritis does not have therapeutical effect.

Summary of the invention

The objective of the invention is to: a kind of medicine with treatment by Chinese herbs stomach, enteropathy is provided, is particularly useful for the medicine of atrophic gastritis and chronic colitis; The present invention also aims to provide the preparation method of this medicine.

Technical scheme of the present invention is based on China's medical science the theory and the principle of treatment digestive system disease is analyzed ingredient and performance with scientific methods, filter out have invigorating the spleen and regulating the stomach, the medicine of the detoxifcation of regulating QI to relieve pain, clearing heat and removing internal wetness, function of promoting blood circulation to disperse blood clots is that feedstock production forms.

The present invention is made by the medicine of following component:

Stigma Croci 8～12 weight portions, Fructus Hordei Germinatus 50～60 weight portions, Rhizoma Dioscoreae 30～40 weight portions,

The Radix Aucklandiae 40～50 weight portions, Fructus Crataegi 40～50 weight portions, Fructus Mume 40～60 weight portions,

Rhizoma Coptidis 30～40 weight portions, Fructus Galangae 10～14 weight portions, Pericarpium Citri Reticulatae 50～60 weight portions,

The Rhizoma Atractylodis Macrocephalae 9～13 weight portions, Caulis Spatholobi 40～50 weight portions.

The present invention is made by the medicine of following component:

Stigma Croci 8～11 weight portions, Fructus Hordei Germinatus 50～55 weight portions, Rhizoma Dioscoreae 33～38 weight portions,

The Radix Aucklandiae 40～42 weight portions, Fructus Crataegi 40～45 weight portions, Fructus Mume 48～52 weight portions,

Rhizoma Coptidis 32～36 weight portions, Fructus Galangae 10～12 weight portions, Pericarpium Citri Reticulatae 50～55 weight portions,

The Rhizoma Atractylodis Macrocephalae 10～12 weight portions, Caulis Spatholobi 40～42 weight portions.

With the method for the medication preparation of above-mentioned component be:

Weight portion by requirement in the component takes by weighing various medicines, Rhizoma Dioscoreae and Fructus Crataegi are dried naturally, then the Radix Aucklandiae, Fructus Hordei Germinatus, Rhizoma Coptidis are toasted under 20 ℃～30 ℃ temperature, Fructus Mume, Stigma Croci are toasted down at 30 ℃～40 ℃, above-mentioned baking crossed with drying in the sun medicine and Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Fructus Galangae etc. pulverized 100～120 mesh sieves jointly, incapsulate.

The dose of packing in every capsules is 0.45～0.5 gram.

With the method for the medication preparation of above-mentioned component be:

Weight portion by requirement in the component takes by weighing various medicines, Rhizoma Dioscoreae and Fructus Crataegi are dried naturally, then the Radix Aucklandiae, Fructus Hordei Germinatus, Rhizoma Coptidis are toasted under 20 ℃～30 ℃ temperature, Fructus Mume, Stigma Croci are toasted down at 30 ℃～40 ℃, above-mentioned baking crossed with drying in the sun medicine and Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Fructus Galangae etc. pulverized 100～120 mesh sieves jointly, medicated powder after sieving is made the watered pill according to a conventional method, and the weight of every watered pill is 0.5 gram.

In medicine of the present invention:

Stigma Croci: nature and flavor Gan Xinwen has the effect of promoting blood circulation and breaking stagnation;

Rhizoma Dioscoreae: strengthening the spleen and tonifying the lung is arranged, reinforce the kidney, control the effect of diarrhea due to hypofunction of the spleen;

Fructus Crataegi: can control that meat long-pending does not disappear, gastral cavity portion distending pain; Again can dissipating blood stasis blood, it is better to offset the function that distension is good for the stomach especially;

Rhizoma Coptidis: bitter in the mouth, the effect of pathogenic fire purging, detoxifcation, dampness is arranged, can treat modest tired, the hematodiarrhoea stomachache of heat, strengthen the effect of gastrointestinal function;

Pericarpium Citri Reticulatae: regulate the flow of vital energy the effect that dampness, intestinal stasis relieving, expectorant, treatment distension and fullness of the chest and abdomen, vomiting are had loose bowels;

The Rhizoma Atractylodis Macrocephalae: sweet-bitter flavor, slightly warm in nature, the effect of tonifying the spleen and stomach dampness is arranged, can control the edema and of having loose bowels that can not transmitting and distributing the fluids causes because of weakness of the spleen and stomach because of phlegm-damp stops the distension and fullness of the chest and abdomen that causes, invigorating the spleen and regulating the stomach is arranged, the effect of antidiarrheal antiemetic;

Caulis Spatholobi: bitter in the mouth, little sweet, warm in nature, the effect that having enriches blood invigorates blood circulation;

Fructus Hordei Germinatus: sweet in the mouth, warm in nature, can digest the food that rests in the intestines and stomach, be applicable to the distension and fullness of the chest and abdomen that stagnates and cause because of food stagnation, the effect that also has promoting the circulation of blood and dissipating blood stasis blood to loose and stagnate.

Said medicine is effective in cure for gastrointestinal disease, behind appropriate compatibility, especially chronic atrophic gastritis, chronic superficial gastritis and chronic colitis is had comprehensive therapeutic effect, and the present invention is simple because of making, therefore the also corresponding product price that reduced.

In order to verify the curative effect of Chinese medicine of the present invention, once 1002 cases were observed treatment, 210 routine patients have been diagnosed as for atrophic gastritis through gastroscopy and according to pathological condition, gastric mucosa changer 80 examples are arranged among the 210 routine patients, clear person's 70 examples of gastric mucosa blood vessel, more obvious and achlorhydria person 60 examples of gastric mucosa blood vessel.Suffer from chronic superficial gastritis 600 examples, chronic colitis patient's 192 examples, these patients come off and ulcer for the medicated porridge mucosa through enteroscopy.Male's 589 examples in 1002 patients, women's 413 examples, 18～30 210 examples wherein,

30～45 years old 210 examples, 45～60 years old person's 390 example, person's 192 examples more than 60 years old, in these cases, by being divided into treatment group and matched group at 2: 1, two groups all have comparability at faces such as age, the sex course of disease, clinical settings.

Treatment group: take medicine of the present invention promptly: instructions of taking is obeyed four at every turn, and four times on the one, serve on two courses of treatment, be one month each course of treatment.

Matched group: take empirical medicine ranitidine.

At period in a medicine, two groups of medicines all can be handled at other symptom of patient, but the Chinese medicine of not handy other any treatment digestive system disease or Western medicine.

After two course of therapy, evaluate and treat the evaluation criteria of enteropathy according to the criterion of therapeutical effect in " the clinical research guideline of new Chinese medicine treatment gastropathy " of Ministry of Health of the People's Republic of China's formulation in 1993 and check.Its therapeutic outcome (seeing the following form):

	The treatment group							Matched group
															The disease type	The example number	Base more		Produce effects		Effectively		The example number	Base more		Produce effects		Effectively
Chronic superficial gastritis	400	Number	Percentage ratio	Number	Percentage ratio	Number	Percentage ratio	200	Number	Percentage ratio	Number	Percentage ratio	Number	Percentage ratio
															?340	??85％	??392	??98％	??360	??90％	??96	?48％	??160	?80％	??130	?65％
		Chronic atrophic gastritis	140	?110	??78％	??129	??92％		??119	??85％	??70	??20	?28％	??42													?60％	??35	?50％
Chronic colitis	128							?102							??80％	??120	??94％	??113	?88％	??64	??19	?30％	??40	?62％	??32	?50％

Embodiment

Be described further below in conjunction with embodiment.

Embodiment 1: take by weighing medicine (is weight portion unit with the kilogram) by following proportioning

8 parts of Stigma Crocis, 60 parts in Fructus Hordei Germinatus, 30 parts of Rhizoma Dioscoreaes,

50 parts of the Radix Aucklandiae, 40 parts of Fructus Crataegis, 30 parts of Rhizoma Coptidis,

60 parts of Fructus Mumes, 50 parts of Pericarpium Citri Reticulataes, 14 parts of Fructus Galangaes,

9 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts of Caulis Spatholobis.

Preparation method is: Rhizoma Dioscoreae and Fructus Crataegi are dried naturally, the Radix Aucklandiae, Fructus Hordei Germinatus, Rhizoma Coptidis are toasted under 20 ℃～30 ℃ temperature, Fructus Mume, Stigma Croci are toasted down at 30 ℃～40 ℃, again with medicines such as Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Fructus Galangaes and above-mentioned baking is crossed and the drying in the sun medicine is pulverized jointly, cross 100～120 mesh sieves, then by certain dose branch capsule of packing into, every capsules content is 0.45～5 gram, and this is capsular manufactures and should meet capsule preparations requirement in the Pharmacopoeia of People's Republic of China the 5th edition.

Embodiment 2: take by weighing medicine (is weight portion unit with the gram) by following proportioning

12 parts of Stigma Crocis, 50 parts in Fructus Hordei Germinatus, 40 parts of Rhizoma Dioscoreaes,

40 parts of the Radix Aucklandiae, 50 parts of Fructus Crataegis, 40 parts of Rhizoma Coptidis,

40 parts of Fructus Mumes, 60 parts of Pericarpium Citri Reticulataes, 10 parts of Fructus Galangaes,

13 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts of Caulis Spatholobis.

Method for production by claim 1 manufactures capsule.

Embodiment 3: take by weighing medicine (is weight portion unit with the kilogram) by following proportioning

11 parts of Stigma Crocis, 55 parts in Fructus Hordei Germinatus, 33 parts of Rhizoma Dioscoreaes,

42 parts of the Radix Aucklandiae, 40 parts of Fructus Crataegis, 32 parts of Rhizoma Coptidis,

48 parts of Fructus Mumes, 55 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Galangaes,

10 parts of the Rhizoma Atractylodis Macrocephalaes, 42 parts of Caulis Spatholobis.

Preparation method is: the method by embodiment 1 is made powdery with said medicine, then makes watered pill according to a conventional method, and every ball is 5 grams.

Embodiment 4: take by weighing medicine (is weight portion unit with the kilogram) by following proportioning

10 parts of Stigma Crocis, 52 parts in Fructus Hordei Germinatus, 38 parts of Rhizoma Dioscoreaes,

48 parts of the Radix Aucklandiae, 45 parts of Fructus Crataegis, 36 parts of Rhizoma Coptidis,

52 parts of Fructus Mumes, 52 parts of Pericarpium Citri Reticulataes, 11 parts of Fructus Galangaes,

12 parts of the Rhizoma Atractylodis Macrocephalaes, 46 parts of Caulis Spatholobis.

Preparation method by embodiment 3 is made the watered pill.

Claims (5)

1, a kind of medicine for the treatment of atrophic gastritis and chronic colitis, it is characterized in that: it is made up of the medicine of following component:

Stigma Croci 8～12 weight portions, Fructus Hordei Germinatus 50～60 weight portions, Rhizoma Dioscoreae 30～40 weight portions,

The Radix Aucklandiae 40～50 weight portions, Fructus Crataegi 40～50 weight portions, Fructus Mume 40～60 weight portions,

Rhizoma Coptidis 30～40 weight portions, Fructus Galangae 10～14 weight portions, Pericarpium Citri Reticulatae 50～60 weight portions,

The Rhizoma Atractylodis Macrocephalae 9～13 weight portions, Caulis Spatholobi 40～50 weight portions.

2, medicine according to claim 1 is characterized in that: it is made up of the medicine of following component:

Stigma Croci 8～11 weight portions, Fructus Hordei Germinatus 50～55 weight portions, Rhizoma Dioscoreae 33～38 weight portions,

The Radix Aucklandiae 40～42 weight portion Fructus Crataegis 40～45 weight portions, Fructus Mume 48～52 weight portions,

Rhizoma Coptidis 32～36 weight portions, Fructus Galangae 10～12 weight portions, Pericarpium Citri Reticulatae 50～55 weight portions,

The Rhizoma Atractylodis Macrocephalae 10～12 weight portions, Caulis Spatholobi 40～42 weight portions.

3, the method with the medication preparation of claim 1 or claim 2 component is:

Weight portion by requirement in the component takes by weighing various medicines, Rhizoma Dioscoreae and Fructus Crataegi are dried naturally, then the Radix Aucklandiae, Fructus Hordei Germinatus, Rhizoma Coptidis are toasted under 20 ℃～30 ℃ temperature, Fructus Mume, Stigma Croci are toasted down at 30 ℃～40 ℃, above-mentioned baking crossed with drying in the sun medicine and Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Fructus Galangae etc. pulverized 100～120 mesh sieves jointly, incapsulate.

4, preparation method according to claim 3 is characterized in that: the dose of packing in every capsules is 0.45～0.5 gram.

5, the method with the medication preparation of claim 1 or claim 2 component is:

Weight portion by requirement in the component takes by weighing various medicines, Rhizoma Dioscoreae and Fructus Crataegi are dried naturally, then the Radix Aucklandiae, Fructus Hordei Germinatus, Rhizoma Coptidis are toasted under 20 ℃～30 ℃ temperature, Fructus Mume, Stigma Croci are toasted down at 30 ℃～40 ℃, above-mentioned baking crossed with drying in the sun medicine and Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Fructus Galangae etc. pulverized 100～120 mesh sieves jointly, medicated powder after sieving is made the watered pill according to a conventional method, and the weight of every watered pill is 0.5 gram.