CN1395941A - Oral liquid of strawflower - Google Patents
Oral liquid of strawflower Download PDFInfo
- Publication number
- CN1395941A CN1395941A CN 01122725 CN01122725A CN1395941A CN 1395941 A CN1395941 A CN 1395941A CN 01122725 CN01122725 CN 01122725 CN 01122725 A CN01122725 A CN 01122725A CN 1395941 A CN1395941 A CN 1395941A
- Authority
- CN
- China
- Prior art keywords
- moench
- linn
- helichrysum
- filter
- oral liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title abstract description 11
- 241000608894 Helichrysum Species 0.000 title abstract description 4
- 201000008383 nephritis Diseases 0.000 abstract description 10
- 206010018367 Glomerulonephritis chronic Diseases 0.000 abstract description 8
- 230000001154 acute effect Effects 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 abstract description 2
- 229930003944 flavone Natural products 0.000 abstract description 2
- 150000002212 flavone derivatives Chemical class 0.000 abstract description 2
- 235000011949 flavones Nutrition 0.000 abstract description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 241000035890 Helichrysum arenarium Species 0.000 description 7
- 241001579678 Panthea coenobita Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GSEMDSHDLFBDML-UHFFFAOYSA-N O.OC=O.CCOC(C)=O Chemical compound O.OC=O.CCOC(C)=O GSEMDSHDLFBDML-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010041277 Sodium retention Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
An oral liquid for treating acute or chronic nephritis is prepared from growing-in-sand strawflower through extracting flavone and flavonoside in water, and depositing in alcohol. Its advantages are high curative effect, low toxic by-effect, and no recurrence.
Description
Technical field
The present invention relates to a kind of simple prescription preparation, be used in particular for treating acute and chronic nephritis.
Technical background
The acute and chronic nephritis of treatment treatment is at present generally lain up diet control and symptomatic treatment clinically.According to " nephrology " (Wang Haiyan edits second edition) record, to acute nephritis lie up, diet control, symptomatic treatment, key link is prevention and treatment water, sodium retention, the control circulating blood volume, thereby reach the purpose of mitigation symptoms.The acute and chronic nephritis course of disease is long, cures difficulty.According to another the query report that Chinese Chinese medicine documentation retrieval centre Shanghai Univ. of Traditional Chinese Medicine branch center provides, do not see research report with Helichrysum arenarium (Linn.) Moench. treatment acute and chronic nephritis.
Summary of the invention
The present invention is for to make through water extract-alcohol precipitation with the herb of Compositae helichrysum Helichrysum arenarium (Linn.) Moench. Helichrysum arenarium (L.) Moench.The active substance of its treatment nephritis is the total extract of Helichrysum arenarium (Linn.) Moench..Aqueous solution is brown supernatant liquid, and it is sweet to distinguish the flavor of, and little hardship, main component are flavone and flavonoid glycoside, and extracting solution also can be made into granule, tablet, capsule or injection after further concentrating.Finished product is differentiated in order to following method: 1. get this product 1ml, add a little magnesium powder jolting, add 3 of concentrated hydrochloric acid, in 1-2 minute (heating in case of necessity), solution is existing red.2. get control medicinal material 0.5g, add water 5ml, reflux 10 minutes is put cold filtration, and filtrate is concentrated into about 0.5ml, compares liquid.Other gets this product is need testing solution, the photograph thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2000) test.Draw above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, get upper strata liquid with ethyl acetate-formic acid-water (10: 2: 3) and do developing solvent, launch the back and take out airing, spray 2% aluminum chloride alcoholic solution, put under the uviol lamp (365nm) and inspect.In the test sample chromatograph, be on the corresponding position of reference substance chromatograph, show the fluorescence speckle of same color respectively.This invention is used for the treatment of acute and chronic nephritis, and effect is obvious, can take effect after general 10 days, and very fast healing, promptly every test rating returns to normal value gradually, significantly shortens the course of disease without this medicine treatment.With this medicine surplus healing in general January, to treat the several months continuously without this medicine treatment acute and chronic nephritis, the patient several years that has all can not heal entirely.
The specific embodiment
Be unit below, the oral liquid of strawflower manufacture method is specified with Helichrysum arenarium (Linn.) Moench. 500g.
Get Helichrysum arenarium (Linn.) Moench. 500g, add water boil three times, each one hour, filter, merging filtrate, normal pressure (or decompression) is concentrated into about 500ml, puts coldly, adds ethanol 500ml, stir evenly, left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into about 450ml, with sucrose 50g, and dissolving, add water and make cumulative volume 500ml, stir evenly, filter, fill, sterilization, promptly.
This oral liquid trial employment period is not seen obvious toxic-side effects.Taking convenience, curative effect is obvious.Instructions of taking: the state of an illness promptly take a favorable turn in every day three times, the each 10-20ml, general patient 10 days, take January continuously after, every test rating can return to normal value gradually, cures the back and is difficult for recurrence.
Character this product is brown supernatant liquid, and it is sweet to distinguish the flavor of, little hardship.
Function is used for the treatment of acute and chronic nephritis with curing mainly.
Consumption and usage every day three times, each 10ml-20ml.
The every bottled 10ml of specification, every milliliter of oral liquid is equivalent to medical material 1 gram.
Storage seals, puts shady and cool place.
Helichrysum arenarium (Linn.) Moench. is the feverfew that is grown in the north, Xinjiang and Central Asia.This plant is a herbaceos perennial, and regeneration capacity is strong, and resource can satisfy large-scale industrial production and use, production technology all is conventional production technology, and no special installation, working condition adopt the national medical GMP of manufacturing enterprise standard, therefore, this oral liquid can carry out industrial-scale production.
Claims (1)
1 oral liquid of strawflower is to make through water extract-alcohol precipitation with the herb of Compositae helichrysum Helichrysum arenarium (Linn.) Moench. Helichrysumarenarium (L.) Moench.The active substance of its treatment nephritis is the total extract of Helichrysum arenarium (Linn.) Moench., and main component is flavone and flavonoid glycoside, it is characterized in that: get Helichrysum arenarium (Linn.) Moench. 500g and add water boil three times, each one hour, filter, merging filtrate, normal pressure (or decompression) is concentrated into about 500ml, puts cold, add ethanol 500ml, stir evenly, left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into about 450ml, with sucrose 50g, dissolving adds water and makes cumulative volume 500ml, stirs evenly, filter fill, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01122725 CN1395941A (en) | 2001-07-12 | 2001-07-12 | Oral liquid of strawflower |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01122725 CN1395941A (en) | 2001-07-12 | 2001-07-12 | Oral liquid of strawflower |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1395941A true CN1395941A (en) | 2003-02-12 |
Family
ID=4664861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01122725 Pending CN1395941A (en) | 2001-07-12 | 2001-07-12 | Oral liquid of strawflower |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1395941A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007083190A3 (en) * | 2006-01-17 | 2007-10-18 | Aboca S P A | Water insoluble helichrysum extract, process for preparing the same and uses thereof |
| WO2016120241A1 (en) * | 2015-01-28 | 2016-08-04 | Purytra Farmaceutici S.P.A. | Process for the preparation of a helichrysum-based product |
-
2001
- 2001-07-12 CN CN 01122725 patent/CN1395941A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007083190A3 (en) * | 2006-01-17 | 2007-10-18 | Aboca S P A | Water insoluble helichrysum extract, process for preparing the same and uses thereof |
| US8147878B2 (en) | 2006-01-17 | 2012-04-03 | Aboca S.P.A. Societa' Agricola | Water insoluble helychrisum extract, process for preparing the same and uses thereof |
| WO2016120241A1 (en) * | 2015-01-28 | 2016-08-04 | Purytra Farmaceutici S.P.A. | Process for the preparation of a helichrysum-based product |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |