CN1371273A - Cosmetic composition containing quaternary ammonium compound and tocopherol - Google Patents

Abstract

The present invention provides a cosmetic composition comprising: (a) at least one quaternary ammonium ingredient; and (b) at least one tocopherol-based antioxidant/radical scavenger. The compositions of the present invention provide the benefits associated with tocopherol-based antioxidants/radical scavengers, such as moisturization and skin protection, while reducing the adverse effects associated therewith, such as irritation, stickiness and/or stickiness sex.

Description

The cosmetic composition that contains quaternary ammonium compound and tocopherol

Technical field

The present invention relates to a kind of cosmetic composition.Particularly, the present invention relates to a kind of cosmetic composition that is used for nursing skin.

Background technology

Skin is by the several layers cellularity, and these cells cover and protect the keratin and the collagen fiber albumen of the skeleton that constitutes skin texture.The outermost layer of these cellular layers is called horny layer, and known its is made of the 25nm albumen bundle that the thick cellular layer of 8nm centers on.The general penetrable cutin tunic of anion surfactant and organic solvent, and destroy the integrity of skin through degreasing (promptly removing the lipid in the horny layer).This skin surface topology structural damage effect is brought harsh feeling, thereby finally can make surfactant or solvent and keratin interact, produce stimulation.Many people's skin all is subjected to this injury every day.In addition, skin can because of other factors as being exposed in the sun, being exposed in the cold air, mechanical friction, in water, soaking etc. and to come to harm.Therefore, need a kind of method of alleviating or improving this injury.

Skin in the prior art, made and claimed the compositions that can help horny layer is remained on its optimum performance, although may run into illeffects in cleaning, work and amusement.Wish that such performance that compositions had is that they have advantages of good skin sense, water retention, moist effect, absorbability and/or friction suction (rub-in) feature.Prior art combinations is attempted by using one or more " skin protection beneficiating ingredients " to realize these performances.For example, tocopherol (vitamin E) is a kind of known antioxidant/radical scavenger.It also is known for example using tocopherol and Tocopheryl derivatives in shampoo and the facial treatment milk at skin nursing products.Had report point out based on the ester of the antioxidant/radical scavenger of tocopherol such as tocopherol acetas, tocopherol aspect the anti-protective effect of avoiding causing the decortication of increase or the ultraviolet radiation that the quality in the horny layer changes is provided and protection skin avoid causing that other environmental factors aspect of skin damage is useful especially.

Look and have direct relation between the consumption of skin protection beneficiating ingredient and compositions provides the effect from beneficial effect to skin.But in fact the content of skin beneficiating ingredient is high more, and the danger of associated unfavorable effect is also just high more.Therefore, up to the present, need balance to comprise the benefit and the detrimental effect relevant of the compositions of high-load skin beneficiating ingredient with this high-load.Therefore, need comprise the high-load skin beneficiating ingredient therefore also provide associated benefits such as skin sense, skin softness and the skin smoothness of high level, but show the relevant detrimental effect of low degree such as the compositions of zest, greasy, cohesiveness or sticky property.

Known quaternary ammonium composition can be used in the cosmetic composition.For example referring to WO-A-99/27904, WO-A-96/32089 and EP-A-789,076.US-A-5 also discloses in 804,205 and has claimed the skin care compositions that highly moistens effect and can not stay " adhesion " or " sticky " residue can be provided.Quaternary ammonium compound, wetting agent and the mean diameter that compositions contains the alkyl with 2 16-22 carbon atoms is lower than the nonirritating hydrophobic microsphere of 50 μ m.It is said that hydrophobic polymerizing microballoons can obviously reduce " cohesiveness " relevant with the wetting agent high-load.US-A-5, the compositions in 804,205 can also comprise emollient such as the vaseline or the mineral oil of low content.

Now be surprised to find that and comprised at least a quaternary ammonium composition and provide skin moisturizing effect and protection skin based on the compositions of the antioxidant/radical scavenger of tocopherol.Therefore these compositionss have increased the user acceptance, and promote user to accept the improved skin protection benefit of the integral body followed better.

Although do not wish to be bound by any theory, believe that the quaternary ammonium composition among the present invention impels the antioxidant/radical scavenger agent based on tocopherol to be deposited on the skin.This has guaranteed the skin protection benefit maximum brought by active substance, and unfavorable effect such as zest, cohesiveness and/or sticky property minimum.And the quaternary ammonium composition help to reduce active substance and loses from skin because of environmental factors such as water or friction.And, believe that the quaternary ammonium composition itself brings skin protection benefit such as good moist effect, advantages of good skin sense, advantages of good skin flexibility.

Summary of the invention

The invention provides a kind of cosmetic composition, said composition comprises:

(a) at least a quaternary ammonium composition; With

(b) at least a antioxidant/radical scavenger based on tocopherol.

Compositions of the present invention has been brought and has been acted on and skin care effect as moistening based on the relevant benefit of the antioxidant/radical scavenger of tocopherol, has reduced associated detrimental effect such as zest, cohesiveness or sticky property simultaneously.

Detailed Description Of The Invention

Compositions of the present invention comprises at least a quaternary ammonium composition and at least a antioxidant/radical scavenger based on tocopherol.These compositions will describe in detail hereinafter.

Compositions of the present invention can be used in the purpose of any appropriate.Especially, compositions of the present invention is suitable for being locally applied on the skin.Particularly, skin care compositions and methods can be forms such as cream frost (creams), emulsion (lotion), gel.Preferred cosmetic composition of the present invention is the oil-in-water emulsion form, wherein comprise one or more oil phases containing aqueous phase continuously, each oil phase contains single oily components or is the mixture of the oily components of miscible or homogenizing form, but described different oil phase contains the material that differs from one another or the mixture of each material.

Compositions of the present invention preferably comprises vesicle (vesicles).Preferably, described vesicle comprises quaternary ammonium compound and based on the antioxidant/radical scavenger of tocopherol.The term that uses among the present invention " vesicle " is meant that described bilayer comprises following quaternary ammonium composition with one or more bilayers sealing, that be generally the spherical geometries arrangement.

Preferably, compositions of the present invention contains and is less than 10% (weight), preferably is less than 5% (weight), more preferably less than 3% (weight), the more preferably anion surfactant of 0% (weight).

Compositions of the present invention preferably is mixed with viscosity and is at least about 1,000mPa.s, preferably be about 1,000 to about 300,000mPa.s, be more preferably 2,500 to about 250,000mPa.s, particularly be about 5,000 to about 200, the product of (000mPa.s 26.8 ℃, net phase, Brookfield DV-II+ spindle CP52/CP41).The quaternary ammonium composition

The present composition must contain at least a quaternary ammonium composition.Be applicable to that the various quaternary ammonium compositions in the cosmetic composition all are applicable to this.Here the term of Cai Yonging " quaternary ammonium composition " is meant the chemical compound that contains quaternary nitrogen atoms or the mixture of chemical compound, and wherein quaternary nitrogen atoms replaces through one or more, preferred two parts that contain 6 or 6 above carbon atoms.Be preferred for quaternary ammonium composition of the present invention and be selected from those compositions that quaternary nitrogen is replaced by two parts, wherein in two parts each part contain more than 10 or 10, preferred 12 or 12 above carbon atoms.The quaternary ammonium composition that highly is preferred for this is to form those of vesicle in polar solvent, and it can detect by microscopic analysis (adopting the polarizing microscope of Nikon Eclipse E800 microscope under 60 times of amplification coefficients).

Contain at least 0.01% (weight), more preferably at least 0.1% (weight), also more preferably at least 1.5% (weight), the further more preferably quaternary ammonium composition of at least 3% (weight) in the preferred compositions of the present invention.

Being preferred for quaternary ammonium composition of the present invention is selected from:

(a) quaternary ammonium compound shown in the general formula (I):

R wherein ₁And R ₂Be C independently ₁-C ₄Alkyl or C ₁-C ₄Hydroxyalkyl or hydrogen atom.R ₃And R ₄Be to contain 8 alkyl or alkenyls approximately independently to about 22 carbon atoms.X ^-Be the become salt anionic compatible with other adjuvant composition with quaternary ammonium compound.

Preferred this class quaternary ammonium compound is the quaternary ammonium with general formula (I), wherein R ₁And R ₂Be methyl or ethoxy, and R ₃And R ₄Be alkyl group or the alkenyl that comprises the straight or branched of at least 11 carbon atoms, preferred at least 15 carbon atoms.

(b) general formula (II) or (III) shown in quaternary ammonium compound:

Each R wherein ₅The unit is independently selected from the C of H, side chain or straight chain ₁-C ₆The C of alkyl, side chain or straight chain ₁-C ₆Hydroxyalkyl and composition thereof, preferably methyl and ethoxy; Each R ₆The unit is straight or branched C independently ₁₁-C ₂₂Alkyl, straight or branched C ₁₁-C ₂₂Alkenyl, and composition thereof; X ^-Be can be compatible with the adjuvant composition with the skin care active composition anion; M is 1-4, is preferably 2; N is 1-4, is preferably 2, and Q is selected from following carbonyl unit:

With

R wherein ₇Be H, C ₁-C ₄Alkyl, C ₁-C ₄Hydroxyalkyl and composition thereof.

In the example of above-mentioned quaternary ammonium compound, unit-QR ₆Containing generally is the fatty acyl group unit of being derived and being obtained by the triglyceride source.The triglyceride source is preferably derived from Adeps Bovis seu Bubali, partially hydrogenated Adeps Bovis seu Bubali, Adeps Sus domestica, partially hydrogenated Adeps Sus domestica, vegetable oil and/or partially hydrogenated vegetable oil, as Canola oil, safflower oil, Oleum Arachidis hypogaeae semen, rapeseed oil, sunflower oil, Semen Maydis oil, soybean oil, tall oil, Testa oryzae wet goods, and these oily mixture.

Counter ion counterionsl gegenions X in the above-claimed cpd ^-Can be any compatible anion, the anion of strong acid preferably, for example chloride ion, bromide ion, methylsulfate, ethyl sulphate, sulfate radical, nitrate anion etc. are more preferably chloride ion or methylsulfate.Anion also can but preferably do not have double charge, X in this case ^-Represent group half.

The preferred quaternary ammonium compound of the present invention is diester and/or the diamides quaternary ammonium compound (DEQA) shown in general formula (II), diester and diamides, and wherein carbonyl Q is selected from:

With

Adeps Bovis seu Bubali, Canola oil and Petiolus Trachycarpi oil are convenient and the economic unitary source of fatty acyl group, are suitable in the present invention as R ₆The unit.

Counter ion counterionsl gegenions X ^-Can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X only exists as the counter ion counterionsl gegenions of positively charged quaternary ammonium compound.Do not consider within the scope of the invention it is defined as specific anion.

When stipulating diester in the present invention, wherein will comprise the monoesters and three esters of the common existence that brings in the preparation process.

(c) general formula (IV) or (V) shown in quaternary ammonium compound:

R wherein ₉Be C ₁₅-C ₂₁Acyclic aliphatic hydrocarbyl, and R ₁₀Be C ₁-C ₆Alkyl or alkenyl.

It is about 4 that the pKa value of this class ammonium compounds is no more than, and can produce cationic charge immediately when disperseing in aqueous solution, and condition is that the pH of final composition is no more than about 6.

(d) general formula (VI) or (VII) shown in quaternary ammonium compound:

R wherein ₉And R ₁₀As hereinbefore defined, R ₁₁Be selected from C ₁-C ₄Alkyl and hydroxyalkyl.

Counter ion counterionsl gegenions X ^-Can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X only exists as the counter ion counterionsl gegenions of positively charged quaternary ammonium compound.Do not consider in the scope of the invention it is defined as specific anion.

(e) general formula (VIII) or (IX) shown in quaternary ammonium compound:

Wherein, n is 1-6, R ₉Be selected from C ₁₅-C ₂₁Acyclic aliphatic hydrocarbyl, and R ₁₂Be C ₁-C ₄Alkyl and hydroxyalkyl.

It is about 4 that the pKa value of this class ammonium compounds (VIII) is no more than, and can produce cationic charge in position when disperseing in aqueous solution, and condition is that the pH of final composition is no more than about 6.

Counter ion counterionsl gegenions X ^-(IX) can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X only exists as the counter ion counterionsl gegenions of positively charged quaternary ammonium compound.Do not plan in the scope of the invention it is defined as specific anion.

(f) general formula (X), (XI), (XII) or (XIII) shown in two quaternary ammonium compounds:

R wherein ₅, R ₆, Q, n and X ^-Identical with above-mentioned general formula (II) with the definition (III), R ₁₃Be selected from C ₁-C ₆Alkylidene, preferably ethylidene, and z are 0-4.

(g) mixture of above-mentioned quaternary ammonium compound.

Be preferred for quaternary ammonium composition among the present invention and be described in above-mentioned (b) part like that.Particularly, preferably diester shown in above-mentioned general formula (II) and/or diamides quaternary ammonium (DEQA) chemical compound.The diester that is preferred among the present invention is R in the chemical compound shown in the general formula (II) ₅, R ₆, and X ^-As previously mentioned, and Q be those that are shown below:

The diamides that is preferred among the present invention is R in the chemical compound shown in the general formula (II) ₅, R ₆And X ^-As previously mentioned, and Q be those that are shown below:

The example that is applicable to the preferred quaternary ammonium compound of the present composition is: N; N-two (canola acyl group-oxygen-ethyl)-N; N-alkyl dimethyl ammonium chloride, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride and their mixture.Be particularly preferred for the N of being of the present invention, N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) methylsulfuric acid ammonium.

Although preferred quaternary ammonium compound is derived from " canola acyl group (canolyl) " fatty acyl group; but the example of the quaternary ammonium compound that other is suitable for can be by following displaced other fatty acyl group derived from " canola acyl group " in the above-mentioned example wherein: " Adeps Bovis seu Bubali acyl group, cocoyl, palmityl (palmyl), lauroyl, oleoyl, Oleum Ricini acyl group, stearyl, palmityl (palmityl) " substitutes, and these are corresponding to the unitary triglyceride of these fatty acyl groups source of deriving.These alternative fatty acyl group sources can comprise saturated entirely, perhaps preferably to the undersaturated chain of small part.Antioxidant/radical scavenger based on tocopherol

Compositions of the present invention also comprises at least a antioxidant/radical scavenger based on tocopherol.Preferably antioxidant/the radical scavenger based on tocopherol is selected from other ester of tocopherol (vitamin E), tocopherol acetas, tocopherol sorbic acid ester, tocopherol and their mixture.Preferred tocopherol acetas.For example, in topical composition, use and comprise the Renascin of tocopherol acetas and use it for and be described among the present invention in the United States Patent (USP) 5786384.

Preferably, compositions of the present invention comprises the 0.1%-10% that accounts for composition weight, more preferably antioxidant/the radical scavenger based on tocopherol of 0.1%-5%.Optional member

Can contain various optional components in the present composition, these optional members are suitable for that the present composition is had more makes us beauty treatment or the aesthetic characteristic accepted, and additional result of use perhaps is provided.These optional members commonly used are well known to those of ordinary skill in the art.These optional members comprise the various compositions that are applicable to cosmetics, as " international cosmetics dictionary of CTFA and handbook (CTFA InternationalCosmetic Ingredient Dictionary and Handbook), the 7th edition, Wenninger and McEwen compile, (cosmetics, toilet articles and fragrance association company, Washington, D.C., 1997)).Below listed some non-limiting example in these optional members.Skin beneficiating ingredient

Preferred especially compositions of the present invention comprises skin beneficiating ingredient.Used term " skin beneficiating ingredient " refers to and anyly for example brings moist effect, protective effect, skin sense, skin softness and/or the chemical compound of skin flatness benefit or the mixture of chemical compound to skin among the present invention.Preferred skin beneficiating ingredient used in this invention is wetting agent, emollient and their mixture.Preferably, compositions of the present invention comprises emollient and wetting agent.

Preferably, compositions of the present invention comprises the skin beneficiating ingredient of at least 1% weight.More preferably, compositions of the present invention comprises 2%-70%, preferred 5%-60%, the more preferably skin beneficiating ingredient of 10%-55% weight.Wetting agent

The particularly preferred optional member that is used in the present composition is a wetting agent.The term " wetting agent " that the present invention uses is meant the material that can make skin have the water conservation benefit.The preferred present composition comprises at least 1% (weight), more preferably at least 5% (weight), more preferably at least 10% (weight) also, the further preferred wetting agent of at least 20% (weight).

Variously be applicable to that the wetting agent in the cosmetic composition all is applicable to the present invention.The non-limiting example that is applicable to wetting agent of the present invention is disclosed in WO98/22085, among WO98/18444 and the WO97/01326.The wetting agent that is preferred among the present invention is selected from, but is not limited to: aminoacid and derivant thereof, as proline and arginine aspartate; 1,3 butylene glycol, propylene glycol and water; and Korean pine platymiscium (codiumtomentosum) extract, collagen amino acid or peptide, kreatinin; diglycerol, biological polyoses glue-1 (biosaccharide-1), glucosamine salt; glucuronate, glutamate, Glu, polyethylene glycol glycerol ether (for example glycerin polyoxyethylene ether 20); glycerol; glycerol list propoxylate, glycogen, hexanediol; Mel and extract thereof or derivant; hydrogenated starch hydrolysates, hydrolysis mucopolysaccharide, inositol; keratin aminoacid; urea, LAREX A-200 (available from Larex), glycosaminoglycans; methoxyl group PEG-10; methyl gluceth-10 and-20 (all can be positioned at Edison, NJ) available from Amerchol; methyl glucoside; the 3-methyl isophthalic acid, 3-butanediol, N-acetyl glucosamine salt; Polyethylene Glycol and derivant thereof are (as the PEG15 butanediol; PEG4, PEG5 tetramethylolmethane, PEG6; PEG8; PEG9), tetramethylolmethane, 1; the 2-pentanediol; the PPG-1 glycerin ether, PPG-9,2-Pyrrolidone-5-carboxylic acid and salt thereof such as glyceryl PCA; the sugar isomerate; SEACARE (available from Secma), sericin, Silk Amino Acids; the acetyl group hyaluronate sodium; hyaluronate sodium, poly (sodium aspartate), polyglutamic acid sodium; sorbeth20; sorbeth6, sugar and sugar alcohol; and derivant such as glucose, mannose and polyglycereol sorbitol; trehalose; triglycerin, trimethylolpropane, three (methylol) aminomethane salt; yeast extract, and their mixture.

More preferably, be used for wetting agent of the present invention and be selected from: glycerol, urea, butanediol, Polyethylene Glycol and derivant thereof, and their mixture.Also more preferably, being used for wetting agent of the present invention is selected from: glycerol, urea and their mixture, particularly glycerol.Emollient

Another highly preferred optional member is emollient (emollient) in the present composition.Slickness and flexibility that emollient is used for lubricated skin, promotes skin, prevention or alleviate xerosis cutis, and/or protection skin.Knownly there are various suitable emollient, and all can be with in the present invention.Many examples that are suitable for use as the material of emollient have been comprised in " cosmetic science and the technology " that Sagarin showed (Cosmetics, Science and Technology) (the 2nd edition, the 1st volume, 32-43 page or leaf (1972)).Preferred compositions of the present invention comprises the emollient greater than 1% (weight), more preferably is at least 5% (weight), also more preferably is at least the emollient of 10% (weight).

The emollient that preferably is applicable to this is selected from:

I) contain about 7 straight chain and branched-chain hydrocarbons, as dodecane, squalane, vaseline, cholesterol and their derivant, Parleam, 2-Methylpentadecane and C to about 40 carbon atoms ₇-C ₄₀Isoparaffin (is C ₇-C ₄₀Branched-chain hydrocarbons).

Ii) C ₁-C ₃₀Carboxylic acid and C ₂-C ₃₀The C of dicarboxylic acids ₁-C ₃₀Alcohol ester, isononyl isononanoate for example, isopropyl myristate, propanoic acid myristin, isopropyl stearate, behenic acid docosane alcohol ester, di-2-ethylhexyl maleate, diisopropyl adipate and dilinoleic acid diisopropyl ester.

Iii) C ₁-C ₃₀The monoglyceride of carboxylic acid, two glyceride and triglyceride and ethoxylated derivative thereof.The polyethyleneglycol derivative of the glyceride that is suitable for comprises: PEG-20 Semen Armeniacae Amarum glyceride, PEG-60 Semen Armeniacae Amarum glyceride, PEG-11 American Avocado Tree glyceride, PEG-6 suffering/caprin, PEG-8 suffering/caprin, PEG-20 corn glyceride, PEG-60 corn glyceride, PEG-60 Radix Oenotherae erythrosepalae oil glyceride, PEG-7 glyceryl cocos nucifera oil ester, PEG-30 glyceryl cocos nucifera oil ester, PEG-40 glyceryl cocos nucifera oil ester, PEG-78 glyceryl cocos nucifera oil ester, PEG-80 glyceryl cocos nucifera oil ester, PEG-12 glyceryl dioleate, PEG-15 glyceryl isostearate, PEG-20 glyceryl isostearate, PEG-30 glyceryl isostearate, PEG-75 cocoa butter glyceride, PEG-20 hydrogenated palm oil glyceride, PEG-70 Fructus Mangifera Indicae glyceride, PEG-13 ermine YOUGAN grease, PEG-75 sal tree fat glyceride, PEG10 olive oil glyceride, PEG-12 palm-kernel oil glyceride, PEG-45 palm-kernel oil glyceride, PEG-8 glyceryl laurate and PEG-30 glyceryl laurate.The mixture of the polyethyleneglycol derivative of glyceride also can be used among the present invention.

Iv) C ₁-C ₃₀The alkylidene diol ester of carboxylic acid, for example C ₁-C ₃₀The ethylene glycol ester of carboxylic acid and diester, and propylene glycol monoester and diester, for example diglycol stearate.

V) organopolysiloxane oil.Organopolysiloxane oil can be mixture volatile, nonvolatile or volatility and non-volatile polysiloxanes.Term used herein " nonvolatile " is meant and is liquid under environmental condition, and flash-point (under 1 atmospheric pressure) is more than or equal to those about 100 ℃ polysiloxanes.Term used herein " volatile " is meant all other polysiloxane oil.The organopolysiloxane oil that is suitable for can be selected from the volatility of leap relative broad range and the various polysiloxanes of viscosity.Preferred non-volatile polysiloxanes.The polysiloxanes that is suitable for is disclosed in United States Patent (USP) 5,069,897 (December was authorized on the 3rd in 1991).Be preferred for organopolysiloxane of the present invention and be selected from polydimethylsiloxane that poly-alkylsiloxane, alkyl replace, dimethiconol (dimethiconols), poly-alkaryl siloxanes and composition thereof.More preferably being used for of the present invention is poly-alkylsiloxane and Cyclomethicone (cyclomethicones).Polydimethylsiloxane preferably in the poly-alkylsiloxane.

Vi) vegetable oil and hydrogenated vegetable oil.The example of vegetable oil and hydrogenated vegetable oil comprises: the partial hydrogenation of the oil in safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, pilchardine, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, rapeseed oil, Semen Lini oil, Testa oryzae oil, Oleum Pini, Oleum sesami, sunflower oil, above-mentioned source and perhydrogenate form, and their mixture.

Vii) animal oil, for example cod liver oil, lanoline and derivant thereof are as acetylizad lanoline and lanolin fatty acid isopropyl ester.Preferred lanolin oil.

The viii) operable C that also has polypropylene glycol ₄-C ₂₀The C of alkyl ether, polypropylene glycol ₁-C ₂₀Carboxylate and two-C ₈-C ₃₀Alkyl ether, example comprise PPG-14 butyl ether, PPG-15 stearyl ether, dicaprylyl ether, dodecyl Octyl Ether and composition thereof.

Ix) polyol carboxylic acid ester.

X) mixture of mentioned component.

The emollient that is preferred in the present composition is selected from: dodecane, squalane, cholesterol and derivant thereof, 2-Methylpentadecane, isononyl isononanoate, vaseline, lanoline and derivant thereof, safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, polyol carboxylic acid ester and their mixture.More preferably be used for emollient of the present invention and be selected from polyol carboxylic acid ester, vaseline and their mixture.

These esters are derived from sugar or polyol moiety and one or more carboxylic moiety.Depend on to constitute the sour and sugared of ester, these esters can be the liquid or solid form at ambient temperature.The example of liquid ester comprises: four oleic acid glucose esters, glucose four esters of (unsaturated) soya fatty acid, mannose four esters of mixed soya fatty acid, oleic galactose four esters, linoleic arabinose four esters, xylose four linoleates, five oleic acid gala sugar esters, four oleic acid sorbitol esters, unsaturated soya fatty acid sorbitol six esters, the five oleic acid esters of xylitol, four oleic acid sucrose ester, five oleic acid sucrose ester, six oleic acid sucrose ester, seven oleic acid sucrose ester, eight oleic acid sucrose ester and composition thereof.The example of solid ester comprises: sorbitol six esters, carboxylate moiety wherein are that mol ratio is 1: 2 palm acid ester and an Arachidate; Raffinose octaester, carboxylate moiety wherein are that mol ratio is 1: 3 linoleate and a docosane acid esters; Maltose seven esters, wherein esterification carboxylic moiety are that mol ratio is 3: 4 sunflower oil fatty acid and a lignocerane acid esters; The octaester of sucrose, wherein esterification carboxylic moiety are that mol ratio is 2: 6 oleate and a docosane acid esters; And the octaester of sucrose, wherein esterification carboxylic moiety is that mol ratio is 1: 3: 4 laurate, linoleate and a docosane acid esters.Preferred solid matter is an Olestra, and wherein esterification degree is 7-8, and fatty acid part wherein is C ₁₈Single-and/or two-unsaturated acids and behenic acid, wherein the mol ratio of unsaturated acids and behenic acid is 1: 7-3: 5.Particularly preferred sugar cube polyester is the octaester of sucrose, wherein contains about 7 22 carbon fatty acids part and about 1 oleic acid part in the molecule.Other material comprises Oleum Gossypii semen or soya fatty acid sucrose ester.These Esters also are disclosed in United States Patent (USP) 2,831,854; United States Patent (USP) 4,005,196 (Jandacek, on January 25th, 1977 authorized); United States Patent (USP) 4,005,195 (Jandacek, on January 25th, 1977 authorized), United States Patent (USP) 5,306,516 people such as (, on April 26th, 1994 authorized) Letton; United States Patent (USP) 5,306,515 (people such as Letton, on April 26th, 1994 authorized); United States Patent (USP) 5,305,514 (people such as Letton, on April 26th, 1994 authorized); United States Patent (USP) 4,797,300 (people such as Jandacek, on January 10th, 1989 authorized); United States Patent (USP) 3,963,699 (people such as Rizzi, on June 15th, 1976 authorized); United States Patent (USP) 4,518,772 (Volpenhein, on May 21st, 1985 authorized); And United States Patent (USP) 4,517,360 (Volpenhein, on May 21st, 1985 authorized).

Be applicable to that polyol esters of fatty acids of the present invention can be prepared by the known the whole bag of tricks of those of ordinary skills.These methods comprise that the various catalyst of employing carry out ester exchange by polyhydric alcohol and methyl, ethyl or fatty acid glyceride; Adopt fat acyl chloride that polyhydric alcohol is carried out acylation; Adopt fatty acid anhydride that polyhydric alcohol is carried out acylation; And adopt fatty acid that polyhydric alcohol is carried out acylation.For example can be referring to United States Patent (USP) 2,831,854; United States Patent (USP) 4,005, the content described in 196 (Jandacek, on January 25th, 1977 authorized).

Particularly preferred material is the material of the poly-oleic acid sucrose ester of INCI called after.Other skin beneficiating ingredient

Can adopt other skin beneficiating ingredient in the compositions of the present invention.The example that can be used for other skin beneficiating ingredient of the present composition comprises: (a) element-vitamine compound

Except material mentioned above, can contain element-vitamine compound, its precursor and derivant thereof in the present composition.These element-vitamine compounds can be native forms, also can be synthesized forms.The element-vitamine compound that is suitable for comprises: vitamin A (for example, beta-carotene, tretinoin, retinol, retinoid (retinoids), retinyl palmitate, propanoic acid retinol ester etc.), vitamin B (for example, nicotinic acid, nicotiamide, riboflavin, pantothenic acid etc.), vitamin C (for example, ascorbic acid etc.), vitamin D (for example, ergosterol, ergocalciferol, cholecalciferol etc.) and vitamin K (for example, vitamin K, menadione, phthiocol etc.) chemical compound.

The element-vitamine compound that is preferred in the present composition is a vitamin B ₃Chemical compound.Vitamin B ₃Chemical compound is specially adapted to regulate skin, as described in WO-A-97/39733.If use element-vitamine compound, then preferably comprise about 0.01% (weight) in the present composition to about 50% (weight), be more preferably 0.1% (weight) to about 10% (weight), also be more preferably the vitamin B of 0.5% (weight) to about 5% (weight) ₃Chemical compound.

Be used for term " vitamin B of the present invention ₃Chemical compound " be meant the chemical compound that is shown below:

Wherein R is-CONH ₂(being nicotiamide) ,-COOH (being nicotinic acid) or-CH ₂OH (being cigarette base alcohol (nicotinylalcohol)); And derivant; And the salt of above-claimed cpd.

Said vitamin B ₃The example of the derivant of chemical compound comprises: nicotinate comprises the non-distensibility of blood vessel ester of nicotinic acid; Cigarette base alcohol ester, nicotinic acid N-oxide and the nicotinoyl amine n-oxide of nicotinoyl aminoacid, carboxylic acid.

Suitable vitamins B ₃Examples for compounds is well known in the art, and can be available from a plurality of sources, for example the Sigma chemical company (St.Louis, MO); ICN Biomedicines, Inc. (Irvin, CA) and the Aldrich chemical company (Milwaukee, WI).

Element-vitamine compound can pure substantially product form add, or add to separate the form of extract that obtains through suitable physics and/or chemical method by natural origin (for example plant).

Other preferred element-vitamine compound comprises pantothenic acid (pantothenic acid) and/or pantothenic acid precursor or derivant.Pantothenic acid is also referred to as N-(2,4-dihydroxy-3,3-dimethyl butyrate acyl group)-B-alanine, is a kind of in the B compound vitamin, is also referred to as vitamin B sometimes ₅Pantothenic acid is the necessary basis of diet for most of mammals.This material can exist with the form of D (+) shape, L (-) shape and racemate.Referring to, The Merck Index, Tenth Edition, 6687,1007 pages of entry (1983).

Various pantothenic acid precursors or derivant also are known, and/or can synthesize and obtain.The example of indefiniteness comprises alcohol, aldehyde, alcohol ester, acid esters etc.Suitable case description is in United States Patent (USP) 3230228,4514338,4602036,5136093 and 5750122.Especially preferably be used in the present composition is the 01 derivatives of pantothenic acid.This alcohol is also referred to as pantothenylol (panthenol), pantothenol, pantothenyl alcohol, and 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-amide dimethyl butyrate are the stable active sources of pantothenic acid.Similar with parent acid, pantothenylol can exist with the form of D (+) shape, L (-) shape and racemate.Referring to, The Merck Index, Tenth Edition, 2910,426 pages of entry (1983).

Pantothenic acid precursor or derivant can effectively reduce because of individual factors (for example ultrasensitiveness) and/or environmental aspect by vitamin B ₃The zest that chemical compound causes.About environmental aspect, the irritating compositions of reduction of the present invention is at 20 ℃-55 ℃, and preferred 25 ℃-50 ℃, most preferably 30 ℃-45 ℃ temperature and/or 50%-100%, preferred 65%-100% most preferably uses under the relative humidity of 80%-100%.

Be used for the pantothenic acid of compositions of the present invention and/or pantothenic acid precursor or derivant preferably with 0.1%-10%, more preferably 0.1%-5%, also more preferably the amount of 0.5%-3.5% exists.

Preferred compositions of the present invention comprises 0.1%-10%, more preferably 0.1%-5%, more preferably 0.5%-3.5% also, the pantothenylol of further preferred 0.5%-1.5% weight.D-panthenol is also referred to as Dexpanthenol, is particularly preferred among the present invention.(b) crease-resistant (anti-wrinkle) and anti-atrophoderma (anti-skin atrophy) active component

The example that can be used for the crease-resistant and anti-atrophoderma active component in the present composition comprises: lactic acid and derivant thereof; Tretinoin and derivant thereof (for example cis with trans); Retinol; Retinyl ester; Nicotiamide; Salicylic acid and derivant thereof; The D of sulfur-bearing and L aminoacid and derivant and salt, particularly N-acetyl derivative, its preferred examples are N-acetyl group-L-cysteine; Thio-alcohol, for example, ethyl mercaptan; Hydroxy acid; Phytic acid; Thioctic acid; Lysophosphatidic acid, and decorticating agent (skin peelagent) (for example, phenols etc.), but be not limited only to these.(c) antimicrobial and antifungal activity composition

Can be used for the antimicrobial of the present composition and the example of antifungal activity composition comprises: Beta-lactam medicine, quinolones, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4 '-three chloro-2 '-hydroxy diphenyl ether, 3,4,4 '-three chloro-carbanilides, phenyl phenol, phenoxypropanol, the phenoxy group isopropyl alcohol, doxycycline, capreomycin, chlohexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol (ethambutol), esomedina, metronidazole, penta oxygen benzene carbon amidine, gentamycin, kanamycin, lincomycin (lineomycin), methacycline, hexamethylenamine, minocycline (minocycline), neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, quadracycline, erythromycin, erythromycin zinc, erythromycin propionate lauryl sulfate, erythromycin stearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate Capastat sulfate, chlorhexidine gluconate, chlorhexidine dihydrochloride, chlortetracycline hydrochloride, tetramycin hydrochloride, clindamycin hydrochloride, ebutol, the hydrochloric acid metronidazole, hydrochloric acid penta oxygen benzene carbon amidine, gentamycin sulfate, kanamycin sulfate, lincomycin hydrochloride (lineomycin), methacycline hydrochloride, methenamine hippu, mandelamine (methenamine mandelate), minocycline hydrochloride, polygynax, netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, the hydrochloric acid miconazole, amantadine hydrochloride (amanfadine hydrochloride), PK-Merz (Merz) (amanfadine sulfate), Octopirox, chlorxylone, nystatin, tolnaftate (tolnaftate), pyrithione zinc (zinc pyrithione) and clotrimazole.(d) sunscreen actives composition

The present composition also can comprise the sunscreen actives composition.Can use various sunscreen actives compositions among the present invention.These sunscreen actives compositions include organic compounds and salt and inorganic particle material.Although without wishing to be bound by theory, believe that sunscreen can avoid ultraviolet radiation by following one or more mechanism protection skins, described mechanism comprises: absorption, scattering and uv reflectance.The non-limiting example of these sunscreen is disclosed in: United States Patent (USP) 5,087,445 (people such as Hafiey, on February 11st, 1992 authorized); United States Patent (USP) 5,073,372 (people such as Turner, December was authorized on the 17th in 1991); United States Patent (USP) 5,073,371 (people such as Turner, December was authorized on the 17th in 1991); United States Patent (USP) 5,160,731 (people such as Sabatelli, on November 3rd, 1992 authorized); United States Patent (USP) 5,138,089 (Sabatelli, on August 11st, 1992 authorized); United States Patent (USP) 5,041,282 (Sabatelli, on August 20th, 1991 authorized); United States Patent (USP) 4,999,186 (people such as Sabatelli, on March 12nd, 1991 authorized); United States Patent (USP) 4,937,370 (Sabatelli, authorize June 26 nineteen ninety); And people such as Segarin is in the described content of " cosmetic science and technology " (Cosmetics Science and Technology, the VIII chapter is below 189 pages).Preferred sunscreen is selected from: p-methoxycinnamic acid 2-Octyl Nitrite; ethylhexyl salicylate; octocrylene; the hydroxyl methoxy benzophenone; N; N-dimethylaminobenzoic acid 2-Octyl Nitrite; para-amino benzoic acid; 2-phenyl-benzimidazole-5-sulfonic acid; the high  ester of salicylic acid; the p-methoxycinnamic acid diethanolamine; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formyl methane; 3-(4-methyl benzal) Camphora; the 3-benzylidene camphor; 4-N; N-dimethylaminobenzoic acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-dimethylaminobenzoic acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-dimethylaminobenzoic acid and 4-hydroxy benzophenone acyl group methane; 4-N; the ester of N-dimethylaminobenzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; 4-N; N-two (2-ethylhexyl)-amino benzoic Acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 4-hydroxy benzophenone acyl group methane; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; 4-N; N-(2-ethylhexyl) methylamino benzoic acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-(2-ethylhexyl) methylamino benzoic acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-hydroxy benzophenone acyl group methane; 4-N, the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; titanium dioxide; zinc oxide; ferrum oxide and composition thereof.

The sunscreen that more preferably is used for the present composition is selected from: N; N-dimethyl-para-amino benzoic acid 2-Octyl Nitrite; p-methoxycinnamic acid 2-Octyl Nitrite; octocrylene; ethylhexyl salicylate; the high  ester of salicylic acid; para-amino benzoic acid; the hydroxyl methoxy benzophenone; 2-Phenylbenzimidazole-5-sulfonic acid; the p-methoxycinnamic acid diethanolamine; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formoxyl methane; 3-(4-methyl benzal) Camphora; the 3-benzylidene camphor; 4-N, the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; titanium dioxide; zinc oxide; ferrum oxide and composition thereof.

The definite consumption of the sunscreen that can use depends on selected sunscreen and sun protection factor (SPF) value that will reach and different.SPF often is used to weigh the photoprotection that sunscreen prevents to produce skin erythema.Referring to Federal Register, 43 volumes, No. 166,38206-38269 page or leaf, on August 25th, 1978.Polar solvent

Can also contain polar solvent in the compositions of the present invention.Any polar solvent that is useful in the cosmetic composition all can be with in the present invention.But the polarity that this polar solvent had should be enough to promote the formation of the vesicle among the present invention.The polar solvent that is preferred in the present composition is a water.

Preferably contain 10% (weight)-90% (weight) in the compositions of the present invention, 20 % (weight)-80% (weight) more preferably, the also polar solvent of 30% (weight)-60% (weight) more preferably.Thickening agent

The present composition preferably contains thickening agent.Any thickening agent that is applicable to cosmetic composition all can be used for the present invention.Preferred thickening is selected from non-ionic water-soluble polymer, aliphatic alcohol and composition thereof.The non-ionic polymers that is suitable for comprises such water-soluble polymer, as cellulose ether (for example hydroxy butyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, ethylhydroxyethylcellulose, hydrophobically modified hydroxyethyl-cellulose and hydroxyethyl-cellulose), poly-(oxygen ethylene), polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, amylose (amulose), ethoxy amylose (amylose), starch and starch derivatives.The aliphatic alcohol that is suitable for is high-molecular weight, the nonvolatile primary alconol with following general formula:

RCH ₂OH

Wherein R is C _8-20Alkyl.They can be made by natural oil or fat, by with in the fatty acid-the COOH carboxyl reduction becomes the hydroxyl functional base to obtain.The aliphatic alcohol that perhaps, can prepare identical or similar structures by conventional synthetic method known in the art.Suitable aliphatic alcohol comprises: tadenan, C ₉-C ₁₁Alcohol, C ₁₂-C ₁₃Alcohol, C ₁₂-C ₁₅Alcohol, C ₁₂-C ₁₆Alcohol, C ₁₄-C ₁₅Alcohol, capryl alcohol, spermaceti/stearyl alcohol, Cortex cocois radicis oleyl alcohol, decanol, different spermol, isooctadecanol, lauryl alcohol, oleyl alcohol, palm kernel alcohol, stearyl alcohol, spermol, tallow alcohol, tridecyl alcohol or myristyl alcohol, but be not to be only limited to these.Other optional member

Can contain various other optional components with in the methods of the invention compositions.These annexing ingredients should be pharmaceutically useful.By functional classification, be applicable to that the non-limiting example of the composition in the present composition comprises: abrasive material, absorbent, anti-acne active ingredient, anticaking agent, dandruff removing agent, antiperspirant, antioxidant, the antiviral activity composition, artificial tanned active component and promoter, bio-additive, bleach, bleach-activating, brightening agent, builder, buffer agent, chelating agen, chemical addition agent, coloring agent, the beauty treatment composition, cleaning agent, the used for cosmetic astringent, the used for cosmetic antibacterial, denaturant, deodorizer, the decortication active component, depilatory, medicinal astringent, dyestuff, transfection agents, enzyme, the external application analgesic agent, foaming agent, correctives, film former, perfume composition, anthelmintic, antifungus agent, on-steroidal anti-inflammatory activity composition, opacifier, oxidation dye, oxidant, the deinsectization composition, pH regulator agent such as citric acid, the pH buffer agent, active constituents of medicine, plasticizer, antiseptic, free radical scavenger, skin or hair or fingernail bleach, skin or hair or fingernail conditioner, skin or hair or fingernail penetration enhancer, stabilizing agent, surfactant, surface amendment, Reducing agent, the temperature inhibitor, viscosity modifier and heating agent are as the heating zeolite.The aesthetic components (aesthetic components) that is applicable to this is as coloring agent, essential oil and skin healing agent.Other optional, materials that is applicable to this comprises: pigment.The pigment that is applicable to the present composition can be organic and/or inorganic constituents.In term pigment scope, also have less colored or the low gloss material, as inferior light finishing agent (matte finishing agents), and light scattering agent.The example of the pigment that is suitable for has ferrum oxide, acyl glutamic acid ferrum oxide, titanium dioxide, ultramarine, D﹠amp; C dyestuff, alkermes and composition thereof.Preparation steps

Preferred compositions of the present invention prepares in the mode that quaternary ammonium compound can form vesicle.Also contain wetting agent in the preferred described vesicle.Preferably, also comprise emollient in the described vesicle.Also more preferably, described vesicle comprises the antioxidant/radical scavenger based on tocopherol.For guaranteeing the optimum performance feature, the preferred present composition is prepared by following steps:

(i) under the temperature that is higher than the quaternary ammonium congruent melting point that all or part of quaternary ammonium composition and wetting agent, water solublity skin care activity composition (if comprising) and preferred polar solvent in addition is mixed mutually;

(ii) this mixture is optional through vigorous stirring;

(iii) in another independent container, prepare Emulsion as follows:

(iv) under the temperature that is higher than the quaternary ammonium congruent melting point, will contain the oil phase of emollient, relevant thickening agent (as long as described thickening agent is oil-soluble), become phase-splitting to mix with any remaining quaternary ammonium based on the antioxidant/radical scavenger of tocopherol.Prepare water separately.Water, relevant thickening agent (as long as described thickening agent is water miscible) are heated under the temperature identical with oil phase with other remaining water soluble ingredient.

(v), under stirring condition, water is combined with oil phase then the about balance of temperature of the oil phase and the water of emulsion.

(vi) when preparation Emulsion, the mixture of making in the step (i) is added in the above-mentioned emulsion through stirring.

Using method

Cosmetic composition of the present invention can conventional mode uses and is used for nursing skin.With the compositions of effective dose, be generally about 0.1 gram to about 50 grams, preferred about 1 gram to about 20 grams are applied to wet or do, on the preferred wet skin.The application of compositions generally includes compositions rubbed on skin and smears, and normally carries out with hands and finger.Then compositions is stayed on the skin, perhaps, preferably skin is carried out rinsing.

Therefore, the preferable methods of nursing skin comprises the following steps:

(a) cosmetic composition with effective dose is administered on the skin,

(b) rinsing skin.

Preferred aspect of the present invention relates to said method, be included in be applied to compositions on the moist skin before, compositions is administered on the dry skin.Therefore, preferable methods comprises:

(i) cosmetic composition with effective dose is applied on the dry skin;

(ii) at the following rinsing skin of shower (shower);

(iii) reuse described compositions; And

(iv) rinsing once more.

Most damages to human body skin repeat repeatedly to be exposed to the compositions that contains surfactant by skin in cleaning process and produce.Have now found that and to use method of the present invention to alleviate this damage.Therefore another method for optimizing comprises:

(i) adopt the compositions that contains surfactant to clean skin;

(ii) rinsing skin;

(iii) compositions of the present invention is used for moist skin;

(iv) rinsing skin.

Also find now compositions of the present invention when introducing, particularly suitable as the part of the cleaning procedure of routine.Therefore another method for optimizing comprises:

(i) application comprises following compositions on skin:

(a) at least a quaternary ammonium compound;

(b) wetting agent; With

(ii) rinsing skin;

(iii) repeating step (i) and (ii) in 48 hours.

Compositions of the present invention can also be used for alleviating because of skin be exposed to damage that ultraviolet radiation causes, swimming or similarly water exercise skin contact the damage that causes with water, shave or peel off the damage that causes or during in bathing skin contact the skin injury that causes with water.

Embodiment

Following examples are used to further specify the preferred embodiment in the scope of the invention.Listed embodiment only is used for explanation, and the present invention is not constituted any qualification, has multiple variation pattern under the situation that does not deviate from the spirit or scope of the present invention.Unless otherwise indicated, all the components is all with the weight percent meter of active component.

Embodiment	???1	???2	???3	???4	???5	???6	???7	???8	???9	???10	???11	???12	???13
																% (weight)
Quaternary ammonium composition (seeing note)	???3	???3	???3	???3	???3	???3	???3	???3	???3	???3	???3	???3	???3	??A
															Glycerol	???32	???32	???32	???32	???32	???32	???32	???-	???-	???-	???-	???-	???-	??A
Urea	???-	???-	???-	???-	???-	???-	???-	???22	???22	???22	???22	???22	???22	??A
															Vaseline	???-	???-	???10	???-	???12	???15	???-	???-	???-	???10	???-	???12	???15	??B
Lanoline 1	???-	???-	???-	???7.5	???5	???-	???15	???-	???-	???-	???10	???10	???-	??B
															The Coronet lanoline 1	???-	???-	???-	???-	???-	???-	???5	???-	???-	???-	???-	???-	???-	??B
Super sterol ester 1	???-	???-	???-	???-	???-	???-	???5	???-	???-	???-	???-	???-	???-	??B
															Sefa cotton oil acid esters	???21	???21	???12	???12	???-	???-	???-	???21	???21	???12	???12	???-	???-	??B
Polydimethylsiloxane 10 centistokes	???-	???0.5	???0.5	???0.5	???-	???0.5	???0.5	???0.5	???-	???-	???-	???0.5	???0.5	??B
															Polydimethylsiloxane 1000 centistokes	???-	???1.0	???1.0	???1.0	???-	???1.0	???1.0	???1.0	???-	???-	???-	???1.0	???1.0	??B
Cyclomethicone	???-	???2.5	???2.5	???2.5	???-	???2.5	???2.5	???2.5	???-	???-	???-	???2.5	???2.5	??B
															Florasun?PEG- 10 2	???-	???2	???-	???2	???-	???3	???-	???1	???-	???-	???3	???-	???-	??B
Methyl parahydroxybenzoate	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	??A
															Propyl p-hydroxybenzoate	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	??B
The EDTA disodium	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	???0.1	??A
															Sodium benzoate	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	???0.3	??B
Nicotiamide	???5	???5	???3	???5	???5	???5	???5	???3	???5	???3	???3	???5	???5	??A
															Pantothenylol	???3	???3	???1	???3	???3	???3	???3	???1	???3	???1	???1	???3	???3	??A
Tocopherol acetate	???2	???2	???0.5	???2	???2	???2	???2	???0.5	???2	???0.5	???0.5	???2	???2	??B

Retinyl palmitate	?0.1	??-	??-	??-	??-	??-	??0.05	??-	???-	??0.1	??-	??-	??-	??B
															Parsol?1789 3	?-	??1	??-	??1	??0.5	??-	??0.1	??-	???1	??-	??1	??-	??1	??B
Parsol?MCX 3	?-	??5	??-	??5	??2.5	??-	??0.5	??-	???5	??-	??5	??-	??5	??B
															Citric acid	?1	??0.5	??1	??0.5	??0.5	??1	??0.5	??1	???0.3	??0.75	??1	??1	??1	??A
Salicylic acid	?-	??0.5	??-	??0.5	??0.5	??-	??0.5	??-	???0.7	??-	??-	??-	??-	??A
															Triethanolamine	?0.1	??-	??-	??0.1	??0.1	??-	??-	??-	???0.1	??-	??-	??0.9	??0.5	??C
Sodium hydroxide	?-	??-	??0.1	??0.1	??0.1	??-	??-	??0.1	???-	??0.1	??-	??-	??-	??C
															Polyquaternium- 10	?-		??-	??1.0		??-	??0.5	??-	???0.6	??-	??-	??-	??0.5	??B
Polymer KG 30 4	?-	??0.7	??-		??0.7	??-		??-	???-	??0.8	??-	??-	??-	??B
															Spice	?0.5	??0.5	??0.5	??0.5	??0.5	??-	??0.5	??0.5	???0.5	??0.5	??0.5	??0.5	??0.5	??E
Spermol	?3	??-	??-	??-	??2.6	??-	??-	??2.2	???-	??2.2	??-	??2.5	??-	??C
															Stearyl alcohol	?2	??-	??-	??-	??1.5	??-	??-	??3.2	???-	??1.1	??-	??1.6	??-	??C
Spermaceti/stearyl alcohol	?-	??-	??4	??-	??0.4	??-	??-	??-	???3.4	??-	??-	??-	??3.4	??C
															Tadenan	?2	??-	??2	??-	??-	??-	??-	??0.6	???-	??0.7	??-	??-	??-	??C
Natrosol?330 Plus	?1	??-	??-	??-	??0.4	??-	??-	??0.7	???0.6		??-	??0.5	??0.25	??C
															Natrosol?250 HHR	?-	??-	??1	??-	??0.3	??-	??-	??-	???-	??1.2	??-	??-	??0.3	??C
Jaguar?HP?105 5	?-	??1.2	?-	??-	??-	??-	??-	??-	???-	??-	??0.8	??-	??-	??D
															Jaguar?C14S 5	?-	??-	?-	??1	??-	??-	??-	??-	???-	??-	??-	??-	??-	??D
Jaguar?C13S 5	?-	??-	?-	??-	??-	??1.2	??-	??-	???-	??-	??-	??-	??-	??D
															Xanthan gum	?-	??-	?-	??-	??-	??-	??2.0	??-	???-	??-	??-	??-	??-	??D
Sodium chloride	?-	??-	?0.1	??-	??-	??-	??0.5	??0.2	???-	??0.3	??-	??-	??-	??A
															Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

Embodiment	??14	??15	??16	??17	??18	??19	??20	??21	??22	??23	??24	??25	???26
																% (weight)
Quaternary ammonium composition (seeing note)	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	???8	??A
															Glycerol	??32	??32	??32	??32	??32	??32	??32	??-	??-	??-	??-	??-	???-	??A
Urea	??-	??-	??-	??-	??-	??-	??-	??22	??22	??22	??22	??22	???22	??A
															Vaseline	??-	??-	??10	??-	??12	??15	??-	??-	??-	??10	??-	??12	???15	??B
Lanoline 1	??-	??-	??-	??7.5	??5	??-	??15	??-	??-	??-	??10	??10	???-	??B
															The Coronet lanoline 1	??-	??-	??-	??-	??-	??-	??5	??-	??-	??-	??-	??-	???-	??B
Super sterol ester 1	??-	??-	??-	??-	??-	??-	??5	??-	??-	??-	??-	??-	???-	??B
															Sefa cotton oil acid esters	??21	??21	??12	??12	??-	??-	??-	??21	??21	??12	??12	??-	???-	??B
Polydimethylsiloxane 10 centistokes	??-	??0.5	??0.5	??0.5	??-	??0.5	??0.5	??0.5	??-	??-	??-	??0.5	???0.5	??B
															Polydimethylsiloxane 1000 centistokes	??-	??1.0	??1.0	??1.0	??-	??1.0	??1.0	??1.0	??-	??-	??-	??1.0	???1.0	??B
Cyclomethicone	??-	??2.5	??2.5	??2.5	??-	??2.5	??2.5	??2.5	??-	??-	??-	??2.5	???2.5	??B
															Florasun?PEG-10 2	??-	??2	??-	??2	??-	??3	???-	??1	??-	??-	??3	??-	???-	??B
Methyl parahydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??A
															Propyl p-hydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??B
The EDTA disodium	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	???0.1	??A
															Sodium benzoate	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	???0.3	??B
Nicotiamide	??5	??5	??3	??5	??5	??5	??5	??3	??5	??3	??3	??5	???5	??A
															Pantothenylol	??3	??3	??1	??3	??3	??3	??3	??1	??3	??1	??1	??3	???3	??A
Tocopherol acetate	??2	??2	??0.5	??2	??2	??2	??2	??0.5	??2	??0.5	??0.5	??2	???2	??B
															Retinyl palmitate	??0.1	??-	??-	??-	??-	??0.05	??-	??-	??-	??-	??-	??-	???0.1	??B
Parsol?1789 3	??-	??1	??-	??1	??0.5	??-	??0.1	??-	??1	??-	??1	??-	???1	??B

Parsol?MCX 3	??-	???5	??-	??5	??2.5	???-	??0.5	????-	????5	???-	??5	????-	???5	??B
															Citric acid	??1	???0.5	??1	??0.5	??0.5	???1	??0.5	????1	???0.3	???0.7	??1	????1	???1	??A
Salicylic acid	??-	???0.5	??-	??0.5	??0.5	???-	??0.5	????-	???0.7	???-	??-	????-	???-	??A
															Triethanolamine	??0.1	???-	??-	??0.1	??0.1	???-	??-	????-	???0.1	???-	??-	????0.9	???0.5	??C
Sodium hydroxide	??-	???-	??0.1	??0.1	??0.1	???-	??-	????0.1	???-	???0.1	??-	????-	???-	??C
															Polyquaternium- 10	??-		??-	??1.0		???-	??0.5	????-	???0.6	???-	??-	????-	???0.5	??B
Polymer KG 30 4	??-	???0.7	?-		??0.7	???-		????-	???-	???0.8	??-	????-	???-	??B
															Spice	??0.5	???0.5	?0.5	??0.5	??0.5	???-	??0.5	????0.5	???0.5	???0.5	??0.5	????0.5	???0.5	??E
Spermol	??3	???-	?-	??-	??2.6	???-	??-	????2.2	???-	???2.2	??-	????2.5	???-	??C
															Stearyl alcohol	??2	???-	?-	??-	??1.5	???-	??-	????3.2	???-	???1.1	??-	????1.6	???-	??C
Spermaceti/stearyl alcohol	??-	???-	?4	??-	??0.4	???-	??-	????-	???3.4	???-	??-	????-	???3.4	??C
															Tadenan	??2	???-	?2	??-	??-	???-	??-	????0.6	???-	???0.7	??-	????-	???-	??C
Natrosol?330?Plus	??1	???-	?-	??-	??0.4	???-	??-	????0.7	???0.6		??-	????0.5	???0.25	??C
															Natrosol?250 HHR	??-	???-	?1	??-	??0.3	???-	??-	????-	???-	???1.2	??-	????-	???0.3	??C
Jaguar?HP?105 5	??-	???1.2	?-	??-	??-	???-	??-	????-	???-	???-	??0.8	????-	???-	??D
															Jaguar?C14S 5	??-	???-	?-	??1	??-	???-	??-	????-	???-	???-	??-	????-	???-	??D
Jaguar?C13S 5	??-	???-	?-	??-	??-	???1.2	??-	????-	???-	???-	??-	????-	???-	??D
															Xanthan gum	??-	???-	?-	??-	??-	???-	??2.0	????-	???-	???-	??-	????-	???-	??D
Sodium chloride	??-	???-	?0.1	??-	??-	???-	??0.5	????0.2	???-	???0.3	??-	????-	???-	??A
															Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

Embodiment	?27	??28	??29	??30	??31	??32	??33	??34	??35	??36	??37	??38	??39	??40	??41
																		% (weight)
Quaternary ammonium composition (seeing note)	?3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	??A
																	Glycerol	?15	??16	??22	??9	??8	??9	??-	??32	??32	??32	??32	??32	??32	??32	??32	??A
Propylene glycol	?-	??16	??-	??-	??-	??5	??12	??-	??-	??-	??-	??-	??-	??-	??-	??A
																	Butanediol	?-	??-	??8	??8	??-	??8	??12	??-	??-	??-	??-	??-	??-	??-	??-	??A
Urea	?-	??-	??-	??12	??-	??2	??9	??-	??-	??-	??-	??-	??-	??-	??-	??A
																	Vaseline	?-	??-	??10	??-	??12	??15	??-	??-	??4	??7.5	??-	??12	??5	??-	??6	??B
Lanoline 1	?-	??-	??-	??7.5	??7.5	??-	??15	??-	??3.5	??-	??3	??-	??-	?-	??-	??B
																	The Coronet lanoline 1	?-	??-	??-	??-	??-	??-	??-	??-	??7	??-	??6.7	??-	??-	??6	??-	??B
Super sterol ester 1	?-	??-	??-	??-	??-	??-	??-	??-	??3.5	??-	??6.5	??-	??3	??6	??3	??B
																	2-Methylpentadecane	?-	??-	??-	??-	??-	??-	??-	??-	??-	??5	??-	??3	??-	??-	??3	??B
Isononyl isononanoate	?-	??-	??-	??-	??-	??-	??-	??-	??-	??3	??-	??5	??-	??-	??-	??B
																	Sefa cotton oil acid esters	?21	??21	??12	??12	??-	??-	??-	??13	??-	??8	??-	??-	??8	??12	??10	??B
Sefa docosane acid esters	?-	??-	??-	??-	??-	??-	??-	??9	??-	??-	??3	??-	??5	??-	???-	??B
																	Polydimethylsiloxane 10 centistokes	?-	??0.5	??0.5	??0.5	??-	??0.5	??0.5	??0.5	??-	??-	??-	??0.5	??0.5	??-	???-	??B
Polydimethylsiloxane 1000 centistokes	?-	??1.0	??1.0	??1.0	??-	??1.0	??1.0	??1.0	??-	??-	??-	??1.0	??1.0	??-	???-	??B
																	Cyclomethicone	?-	??2.5	??2.5	??2.5	??-	??2.5	??2.5	??2.5	??-	??-	??-	??2.5	??2.5	??-	??-	??B
Florasun?PEG-10 2	?-	??2	??-	??2	??-	??3	??-	??1	??-	??-	??3	??-	??-	??2.5	??-	??B
																	Methyl parahydroxybenzoate	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??A
Propyl p-hydroxybenzoate	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??B
																	The EDTA disodium	?0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??A
Sodium benzoate	?0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??B
																	Nicotiamide	?3	??5	??5	??3	??3	??5	??5	??5	??3	??3	??5	??5	??5	??5	??3	??A
Pantothenylol	?1	??3	??3	??1	??1	??3	??3	??3	??1	??1	??3	??3	??3	??3	??1	??A
																	Tocopherol acetate	?0.5	??2	??2	??0.5	??0.5	??2	??2	??2	??0.5	??0.5	??2	??2	??2	??2	??0.5	??B

Retinyl palmitate	??-	??-	??-	??0.1	???-	??0.05	??-	???-	???0.1	???-	???-	???-	???-	???-	???-	?B
																	Parsol?1789 3	??-	??1	??-	??1	???0.5	??-	??1	???-	???1	???-	???1	???-	???0.1	???-	???-	?B
Parsol?MCX 3	??-	??5	??-	??5	???2.5	??-	??5	???-	???5	???-	???5	???-	???0.5	???-	???-	?B
																	Citric acid	??1	??0.5	??1	??0.5	???0.5	??1	??0.5	???1	???0.3	???0.75	???1	???1	???1	???1	???-	?A
Salicylic acid	??-	??0.5	??-	??0.5	???0.5	??-	??0.5	???-	???0.7	???-	???-	???-	???-	???-	???0.5	?A
																	Triethanolamine	??0.1	??-	??-	??0.1	???0.1	??-	??-	???-	???0.1	???-	???-	???0.9	???0.5	???-	???-	?C
Sodium hydroxide	??-	??-	??0.1	??0.1	???0.1	??-	??-	???0.1	???-	???0.1	???-	???-	???-	???-	???0.6	?C
																	Polyquaternium-10	??-	??-	??-	??1.0	???-	??-	??0.5	???-	???0.6	???-	???-	???-	???0.5	???1.0	???-	?B
Polymer KG 30 4	??-	??0.7	??-	??-	???0.7	??-	??-	???-	???-	???0.8	???-	???-	???-	???-	???0.8	?B
																	Spice	??0.5	??0.5	??0.5	??0.5	???0.5	??-	??0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	???0.5	?E
Spermol	??3	??-	??-	??-	???2.6	??-	??-	???2.2	???-	???2.2	???-	???2.5	???-	???-	???3.2	?C
																	Stearyl alcohol	??2	??-	??-	??-	???1.5	??-	??-	???3.2	???-	???1.1	???-	???1.6	???-	???-	???2.6	?C
Spermaceti/stearyl alcohol	??-	??-	??4	??-	???0.4	??-	??-	???-	???3.4	???-	???-	???-	???3.4	???-	???-	?C
																	Tadenan	??2	??-	??2	??-	???-	??-	??-	???0.6	???-	???0.7	???-	???-	???-	???-	???0.2	?C
Natrosol?330?Plus	??1	??-		??-	???0.4	??-	??-	???0.7	???0.6	???-	???-	???0.5	???0.25	???-	???0.6	?C
																	Natrosol?250?HHR	??-	??-	??1	??-	???0.3	??-	??-	???-	???-	???1.2	???-	???-	???0.3	???-	???-	?C
Jaguar?HP?105 5	??-	??1.2	??-	??-	???-	??-	??-	???-	???-	???-	???0.8	???-	???-	???-	???-	?D
																	Jaguar?C14S 5	??-	??-	??-	??1	???-	??-	??-	???-	???-	???-	???-	???-	???-	???-	???-	?D
Jaguar?C13S 5	??-	??-	??-	??-	???-	??1.2	??-	???-	???-	???-	???-	???-	???-	???0.8	???-	?D
																	Xanthan gum	??-	??-	??-	??-	???-	??-	??3.0	???-	???-	???-	???-	???-	???-	???-	???-	?D
Sodium chloride	??-	??-	??0.1	??-	???-	??-	??0.5	???0.2	???-	???0.3	???-	???-	???-	???0.2	???0.1	?A
																	Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	?A

Embodiment	?42	??43	??44	??45	??46	??47	??48	??49	??50	??51	??52	??53	??54	??55	??56
																		% (weight)
The quaternary ammonium composition	?8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??8	??A
																	Glycerol	?15	??16	??22	??9	??8	??9	??-	??32	??32	??32	??32	??32	??32	??32	??32	??A
Propylene glycol	?-	??16	??-	??-	??-	??5	??12	??-	??-	??-	??-	??-	??-	??-	??-	??A
																	Butanediol	?-	??-	??8	??8	??-	??8	??12	??-	??-	??-	??-	??-	??-	??-	??-	??A
Urea	?-	??-	??-	??12	??-	??2	??9	??-	??-	??-	??-	??-	??-	??-	??-	??A
																	Vaseline	?-	??-	??10	??-	??12	??15	??-	??-	??4	??7.5	??-	??12	??5	??-	??6	??B
Lanoline 1	?-	??-	??-	??7.5	??7.5	??-	??15	??-	??3.5	??-	??3	??-	??-	??-	??-	??B
																	The Coronet lanoline 1	?-	??-	??-	??-	??-	??-	??-	??-	??7	??-	??6.7	??-	??-	??6	??-	??B
Super sterol ester 1	?-	??-	??-	??-	??-	??-	??-	??-	??3.5	??-	??6.5	??-	??3	??6	??3	??B
																	2-Methylpentadecane	?-	??-	??-	??-	??-	??-	??-	??-	??-	??5	??-	??3	??-	??-	??3	??B
Isononyl isononanoate	?-	??-	??-	??-	??-	??-	??-	??-	??-	??3	??-	??5	??-	??-	??-	??B
																	Sefa cotton oil acid esters	?21	??21	??12	??12	??-	??-	??-	??13	??-	??8	??-	??-	??8	??12	??10	??B
Sefa docosane acid esters	?-	??-	??-	??-	??-	??-	??-	??9	??-	??-	??3	??-	??5	??-	??-	??B
																	Polydimethylsiloxane 10 centistokes	?-	??0.5	??0.5	??0.5	??-	??0.5	??0.5	??0.5	??-	??-	??-	??0.5	??0.5	??-	??-	??B
Polydimethylsiloxane 1000 centistokes	?-	??1.0	??1.0	??1.0	??-	??1.0	??1.0	??1.0	??-	??-	??-	??1.0	??1.0	??-	??-	??B
																	Cyclomethicone	?-	??2.5	??2.5	??2.5	??-	??2.5	??2.5	??2.5	??-	??-	??-	??2.5	??2.5	??-	??-	??B
Florasun?PEG-10 2	?-	??2	??-	??2	??-	??3	??-	??1	??-	??-	??3	??-	??-	??2.5	??-	??B
																	Methyl parahydroxybenzoate	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??A
Propyl p-hydroxybenzoate	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??B
																	The EDTA disodium	?0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??A
Sodium benzoate	?0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??B
																	Nicotiamide	?3	??5	??5	??3	??5	??5	??5	??5	??3	??3	??5	??5	??5	??5	??3	??A
Pantothenylol	?1	??3	??3	??1	??3	??3	??3	??3	??1	??1	??3	??3	??3	??3	??1	??A
																	Tocopherol acetate	?0.5	??2	??2	??0.5	??2	??2	??2	??2	??0.5	??0.5	??2	??2	??2	??2	??0.5	??B
Retinyl palmitate	?-	??-	??-	??-	??-	??-	??-	??-	??0.05	??-	??-	??0.1	??-	??-	??-	??B

Parsol?1789 3	??1	??1	???-	??1	???0.5	??-	??1	??-	???1	??-	???1	??-	???0.1	???1	???-	??B
																	Parsol?MCX 3	??5	??5	???-	??5	???2.5	??-	??5	??-	???5	??-	???5	??-	???0.5	???5	???-	??B
Citric acid	??1	??0.5	???1	??0.5	???0.5	??1	??0.5	??1	???0.3	??0.7	???1	??1	???1	???1	???-	??A
																	Salicylic acid	??-	??0.5	???-	??0.5	???0.5	??-	??0.5	??-	???0.7	??-	???-	??-	???-	???-	???0.5	??A
Triethanolamine	??0.1	??-	???-	??0.1	???0.1	??-	??-	??-	???0.1	??-	???-	??0.9	???0.5	???-	???-	??C
																	Sodium hydroxide	??-	??-	???0.1	??0.1	???0.1	??-	??-	??0.1	???-	??0.1	???-	??-	???-	???-	???0.6	??C
Polyquaternium-10	??-	??-	???-	??1.0	???-	??-	??0.5	??-	???0.6	??-	???-	??-	???0.5	???1.0	???-	??B
																	Polymer KG 30 4	??-	??0.7	???-	??-	???0.7	??-		??-	???-	??0.8	???-	??-	???-	???-	???0.8	??B
Spice	??0.5	??0.5	???0.5	??0.5	???0.5	??-	??0.5	??0.5	???0.5	??0.5	???0.5	??0.5	???0.5	???0.5	???0.5	??E
																	Spermol	??3	??-	???-	??-	???2.6	??-	??-	??2.2	???-	??2.2	???-	??2.5	???-	???-	???3.2	??C
Stearyl alcohol	??2	??-	???-	??-	???1.5	??-	??-	??3.2	???-	??1.1	???-	??1.6	???-	???-	???2.6	??C
																	Spermaceti/stearyl alcohol	??-	??-	???4	??-	???0.4	??-	??-	??-	???3.4	??-	???-	??-	???3.4	???-	???-	??C
Tadenan	??2	??-	???2	??-	???-	??-	??-	??0.6	???-	??0.7	???-	??-	???-	???-	???0.2	??C
																	Natrosol?330?Plus	??1	??-		??-	???0.4	??-	??-	??0.7	???0.6	??-	???-	??0.5	???0.25	???-	???0.6	??C
Natrosol?250?HHR	??-	??-	???1	??-	???0.3	??-	??-	??-	???-	??1.2	???-	??-	???0.3	???-	???-	??C
																	Jaguar?HP?105 5	??-	??1.2	???-	??-	???-	??-	??-	??-	???-	??-	???0.8	??-	???-	???-	???-	??D
Jaguar?C14S 5	??-	??-	???-	??1	???-	??-	??-	??-	???-	??-	???-	??-	???-	???-	???-	??D
																	Jaguar?C13S 5	??-	??-	???-	??-	???-	??1.2	??-	??-	???-	??-	???-	??-	???-	???0.8	???-	??D
Xanthan gum	??-	??-	???-	??-	???-	??-	??3.0	??-	???-	??-	???-	??-	???-	???-	???-	??D
																	Sodium chloride	??-	??-	???0.1	??-	???-	??-	??0.5	??0.2	???-	??0.3	???-	??-	???-	???0.2	???0.1	??A
Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

1: available from Croda

2: available from Floratech, AZ, USA

3: available from Hoffman La Roche, NJ, USA

4: available from Amerchol, NJ, USA

5: available from Rhodia, NJ, USA note embodiment 1,4,7,9,17,20,22,24, and in 28,36,38,47,49,53,56, used quaternary ammonium compound is a VARISOFT TA100, and available from Goldschmidt, commodity are called VarisoftTA100.Embodiment 2,3, and 5,6,8,10; 15,16,18,19,21,23; 26,27,31,33,34,35; 37,41,45,46,48; in 50,51,52,54,55; used quaternary ammonium compound is N, N-two (canola acyl group-oxygen ethyl)-N-methyl, and N-(2-ethoxy) methylsulfuric acid ammonium, available from Goldschmidt, commodity are called RewoquatV3620.Among the embodiment 11; used quaternary ammonium compound is N; N-two (canola acyl group-oxygen ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium; available from Goldschmidt; among the commodity Rewoquat WE18 embodiment 12 by name; used quaternary ammonium compound is N; N-two (canola acyl group-oxygen ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride is available from Goldschmidt; among exploitation material (WE25) embodiment 13; used quaternary ammonium compound is two (h-tallow acylamino-ethyl) (2-ethoxy) the methylsulfuric acid ammoniums of methyl, and available from Goldschmidt, commodity are called Varisoft 110.Among the embodiment 14, used quaternary ammonium compound is two (Adeps Bovis seu Bubali acylamino-ethyl) (2-ethoxy) the methylsulfuric acid ammoniums of methyl, and available from Goldschmidt, commodity are called Varisoft 222.Among the embodiment 25; used quaternary ammonium compound is methyl isophthalic acid-Adeps Bovis seu Bubali acyl ethyl-2-Adeps Bovis seu Bubali imidazoline; available from Goldschmidt; among the exploitation material embodiment 29; used quaternary ammonium compound is methyl isophthalic acid-Adeps Bovis seu Bubali acylamino-ethyl-2-Adeps Bovis seu Bubali imidazoline; available from Goldschmidt; among the exploitation material embodiment 30; used quaternary ammonium compound is methyl isophthalic acid-Adeps Bovis seu Bubali acyl ethyl-2-Adeps Bovis seu Bubali imidazoline Methylsulfate; in Goldschmidt embodiment 32; used quaternary ammonium compound is methyl isophthalic acid-Adeps Bovis seu Bubali acylamino-ethyl-2-Adeps Bovis seu Bubali imidazoline Methylsulfate; available from Goldschmidt; commodity are called Varisoft 475; among Varisoft 445 embodiment 39; used quaternary ammonium compound is N; N-dimethyl-N-(canola acyl group-oxygen ethyl)-N-(canola acyl group acylamino-ethyl) amine; in Kao embodiment 40; used quaternary ammonium compound is N; N-dimethyl-N (canola acyl group-oxygen ethyl)-N-(canola acyl group acylamino-ethyl) methylsulfuric acid ammonium; in Kao embodiment 42; used quaternary ammonium compound is N; N '-two (2-Adeps Bovis seu Bubali acyl group oxygen ethyl)-N; N; N '; N '-tetramethylene dichloro diammonium is disclosed in United States Patent (USP) 4728337; United States Patent (USP) 4721512; in the United States Patent (USP) 4906413, available from Ciba-Geigy company

Among the embodiment 43, used quaternary ammonium compound is N, N '-two (2-canola acyl group oxygen second

Base)-and N, N '-dimethyl-N, N '-(2-ethoxy)-1,6-hexane methylsulfuric acid diammonium is disclosed in

Among the patent EP0503155A1 and EP0803498 of Goldschmidt-Witco

Among the embodiment 44, used quaternary ammonium compound is by fatty acid, two functional groups (or functional group) acid

With the triethanolamine reaction, then through quaternized dimerization that obtains and oligomeric esters quaternary ammonium compound

(quats), be disclosed in WO98/49132 (Kao) and the United States Patent (USP) 5880289 (Henkel).Method is applicable to the embodiment that comprises component C:

1. pre-composition 1: each component under the condition of the conversion temperature that is higher than selected quaternary ammonium compound in the mixed A group, the quaternary ammonium compound and the water that keep scheduled volume do not add.This pre-composition of vigorous stirring.

2. pre-composition 2: each component in B and the C group is mixed with the remaining quaternary ammonium compound and the water that are not used in the pre-composition 1.Be heated to more than the fusing point of quaternary ammonium compound and oils.

3. pre-composition 1 and 2 is mixed, and be cooled to 40 ℃, stir adding essence.Be applicable to the embodiment that comprises component D:

1. pre-composition 1: each component under the condition of the conversion temperature that is higher than selected quaternary ammonium compound in the mixed A group, the water that keeps scheduled volume does not add.This pre-composition of vigorous stirring.

2. pre-composition 2: stir down, and each component in the D group is mixed with the remaining water that is not used in the pre-composition 1.

With pre-composition 1 and 2 and B and E group in each component mixed.Vigorous stirring.

Compositions in the foregoing description provides good skin protection benefit, as good moist effect, good hydration, advantages of good skin sense, advantages of good skin soft feeling and/or advantages of good skin smooth feeling, have detrimental effect such as greasy, cohesiveness or the sticky property of low degree simultaneously.

Claims (10)

1. cosmetic composition, said composition comprises:

(a) at least a quaternary ammonium composition; With

(b) at least a antioxidant/radical scavenger based on tocopherol.

2. according to the compositions of claim 1, wherein antioxidant/the radical scavenger based on tocopherol is selected from other ester of tocopherol, tocopherol acetas, tocopherol sorbic acid ester, tocopherol and their mixture.

3. according to the compositions of claim 1 or 2, wherein said compositions also comprises pantothenic acid or pantothenic acid derivative.

4. according to the compositions of aforementioned each claim, wherein said compositions also comprises vitamin B ₃Chemical compound.

5. according to the compositions of aforementioned each claim, wherein said compositions also comprises skin beneficiating ingredient.

6. according to the compositions of aforementioned each claim, wherein said compositions also comprises the skin beneficiating ingredient that is selected from wetting agent, emollient and their mixture.

7. according to the compositions of aforementioned each claim, wherein said quaternary ammonium composition is selected from and satisfies general formula (II) or (III) those:

Each R wherein ₅The unit is independently selected from the C of H, side chain or straight chain ₁-C ₆The C of alkyl, side chain or straight chain ₁-C ₆Hydroxyalkyl and composition thereof, preferable methyl and ethoxy; Each R ₆The unit is straight or branched C independently ₁₁-C ₂₂Alkyl, straight or branched C ₁₁-C ₂₂Alkenyl and composition thereof; X ^-Be can be compatible with the adjuvant composition with the skin care active composition anion; M is 1-4, is preferably 2; N is 1-4, is preferably 2, and Q is selected from following carbonyl unit:

With

R wherein ₇Be H, C ₁-C ₄Alkyl, C ₁-C ₄Hydroxyalkyl and composition thereof.

8. according to the compositions of aforementioned each claim, wherein said compositions comprises vesicle, and described vesicle comprises the quaternary ammonium composition and based on the antioxidant/radical scavenger of tocopherol.

9. according to the compositions of aforementioned each claim, wherein said compositions comprises and is less than 5%, preferably is less than 3%, the anion surfactant of preferred 0% weight.

10. the application of the described compositions of aforementioned each claim in nursing skin.