CN1366923A - Nano kindey-benefiting preparation medicine and preparation method - Google Patents
Nano kindey-benefiting preparation medicine and preparation method Download PDFInfo
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- CN1366923A CN1366923A CN 01102064 CN01102064A CN1366923A CN 1366923 A CN1366923 A CN 1366923A CN 01102064 CN01102064 CN 01102064 CN 01102064 A CN01102064 A CN 01102064A CN 1366923 A CN1366923 A CN 1366923A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- 241000005787 Cistanche Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 241000208966 Polygala Species 0.000 claims description 5
- 241001446509 Psoralea Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000600871 Euryale <brittle star> Species 0.000 claims description 4
- 235000006487 Euryale ferox Nutrition 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000893536 Epimedium Species 0.000 abstract 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 abstract 1
- 244000250129 Trigonella foenum graecum Species 0.000 abstract 1
- 229910052891 actinolite Inorganic materials 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 208000016254 weariness Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The present invention discloses a nano Qiangyang Baoshen preparation medicine. It is made up by using 15 Chinese medicinal materials of nano epimedium, nano actinolite, nano cistanche, nano fenugreek, nano bone fat and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of kidney invigorating and YANG supporting, cure mainly the nano kindey-benefiting preparation medicine of mental weariness that insufficiency of kidney-YANG causes, impotence and seminal emission, waist soreness, waist abdomen cold type of pain, the invention still further relates to the method for this medication preparation.
Yang-tonifying kidney-protecting pill is a kind of classical Chinese patent medicine, mainly contains effects such as kidney invigorating and YANG supporting, is used for mental weariness, impotence and seminal emission, waist soreness, waist abdomen cold type of pain that insufficiency of kidney-YANG causes.But traditional Yang-tonifying kidney-protecting pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano kindey-benefiting preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano kindey-benefiting preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Epimedii 25-60 part nanometer Actinolitum 25-60 part nanometer Herba Cistanches 25-60 part
Nanometer Semen Trigonellae 30-80 part nanometer Fructus Psoraleae 30-80 part nanometer Fructus Schisandrae Chinensis 30-60 part
Nanometer Semen Astragali Complanati 25-60 part nanometer Fructus Cnidii 25-60 part nanometer Fructus Rubi 35-80 part
Nanometer Semen Allii Tuberosi 30-60 part nanometer Semen Euryales 40-80 part nanometer Cortex Cinnamomi 15-40 part
Nanometer Fructus Foeniculi 20-44 part nano Poria 25-60 part nanometer Radix Polygalae 25-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Epimedii 30-50 part nanometer Actinolitum 30-50 part nanometer Herba Cistanches 30-50 part
Nanometer Semen Trigonellae 40-60 part nanometer Fructus Psoraleae 40-60 part nanometer Fructus Schisandrae Chinensis 35-50 part
Nanometer Semen Astragali Complanati 30-50 part nanometer Fructus Cnidii 30-50 part nanometer Fructus Rubi 40-60 part
Nanometer Semen Allii Tuberosi 35-50 part nanometer Semen Euryales 50-70 part nanometer Cortex Cinnamomi 20-30 part
Nanometer Fructus Foeniculi 25-34 part nano Poria 30-50 part nanometer Radix Polygalae 30-50 part
The optimum weight proportioning of medicine of the present invention is:
36 parts of 36 parts of nanometer Herba Cistanches of 36 parts of nanometer Actinolitum of nanometer Herba Epimedii
42 parts of 48 parts of nanometer Fructus Schisandrae Chinensis of 48 parts of nanometer Fructus Psoraleaes of nanometer Semen Trigonellae
48 parts of 36 parts of nanometer Fructus Rubies of 36 parts of nanometer Fructus Cnidiis of nanometer Semen Astragali Complanati
24 parts of 60 parts of nanometer Cortex Cinnamomis of 42 portions of nanometer Semen Euryaless of nanometer Semen Allii Tuberosi
36 parts of 36 parts of nanometer Radix Polygalaes of 30 parts of nano Porias of nanometer Fructus Foeniculi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Yang-tonifying kidney-protecting preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano kindey-benefiting preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Yang-tonifying kidney-protecting pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano kindey-benefiting preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as mental weariness that insufficiency of kidney-YANG causes, impotence and seminal emission, waist soreness, waist abdomen cold type of pain, and clinical efficacy significantly is better than traditional Yang-tonifying kidney-protecting pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
36 parts of 36 parts of nanometer Herba Cistanches of 36 parts of nanometer Actinolitum of nanometer Herba Epimedii
42 parts of 48 parts of nanometer Fructus Schisandrae Chinensis of 48 parts of nanometer Fructus Psoraleaes of nanometer Semen Trigonellae
48 parts of 36 parts of nanometer Fructus Rubies of 36 parts of nanometer Fructus Cnidiis of nanometer Semen Astragali Complanati
24 parts of 60 parts of nanometer Cortex Cinnamomis of 42 portions of nanometer Semen Euryaless of nanometer Semen Allii Tuberosi
36 parts of 36 parts of nanometer Radix Polygalaes of 30 parts of nano Porias of nanometer Fructus Foeniculi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
36 parts of 36 parts of nanometer Herba Cistanches of 36 parts of nanometer Actinolitum of nanometer Herba Epimedii
42 parts of 48 parts of nanometer Fructus Schisandrae Chinensis of 48 parts of nanometer Fructus Psoraleaes of nanometer Semen Trigonellae
48 parts of 36 parts of nanometer Fructus Rubies of 36 parts of nanometer Fructus Cnidiis of nanometer Semen Astragali Complanati
24 parts of 60 parts of nanometer Cortex Cinnamomis of 42 portions of nanometer Semen Euryaless of nanometer Semen Allii Tuberosi
36 parts of 36 parts of nanometer Radix Polygalaes of 30 parts of nano Porias of nanometer Fructus Foeniculi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano kindey-benefiting powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
36 parts of 36 parts of nanometer Herba Cistanches of 36 parts of nanometer Actinolitum of nanometer Herba Epimedii
42 parts of 48 parts of nanometer Fructus Schisandrae Chinensis of 48 parts of nanometer Fructus Psoraleaes of nanometer Semen Trigonellae
48 parts of 36 parts of nanometer Fructus Rubies of 36 parts of nanometer Fructus Cnidiis of nanometer Semen Astragali Complanati
24 parts of 60 parts of nanometer Cortex Cinnamomis of 42 portions of nanometer Semen Euryaless of nanometer Semen Allii Tuberosi
36 parts of 36 parts of nanometer Radix Polygalaes of 30 parts of nano Porias of nanometer Fructus Foeniculi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano kindey-benefiting membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano kindey-benefiting preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Epimedii 25-60 part nanometer Actinolitum 25-60 part nanometer Herba Cistanches 25-60 part
Nanometer Semen Trigonellae 30-80 part nanometer Fructus Psoraleae 30-80 part nanometer Fructus Schisandrae Chinensis 30-60 part
Nanometer Semen Astragali Complanati 25-60 part nanometer Fructus Cnidii 25-60 part nanometer Fructus Rubi 35-80 part
Nanometer Semen Allii Tuberosi 30-60 part nanometer Semen Euryales 40-80 part nanometer Cortex Cinnamomi 15-40 part
Nanometer Fructus Foeniculi 20-44 part nano Poria 25-60 part nanometer Radix Polygalae 25-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano kindey-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Epimedii 30-50 part nanometer Actinolitum 30-50 part nanometer Herba Cistanches 30-50 part
Nanometer Semen Trigonellae 40-60 part nanometer Fructus Psoraleae 40-60 part nanometer Fructus Schisandrae Chinensis 35-50 part
Nanometer Semen Astragali Complanati 30-50 part nanometer Fructus Cnidii 30-50 part nanometer Fructus Rubi 40-60 part
Nanometer Semen Allii Tuberosi 35-50 part nanometer Semen Euryales 50-70 part nanometer Cortex Cinnamomi 20-30 part
Nanometer Fructus Foeniculi 25-34 part nano Poria 30-50 part nanometer Radix Polygalae 30-50 part
3, nano kindey-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
36 parts of 36 parts of nanometer Herba Cistanches of 36 parts of nanometer Actinolitum of nanometer Herba Epimedii
42 parts of 48 parts of nanometer Fructus Schisandrae Chinensis of 48 parts of nanometer Fructus Psoraleaes of nanometer Semen Trigonellae
48 parts of 36 parts of nanometer Fructus Rubies of 36 parts of nanometer Fructus Cnidiis of nanometer Semen Astragali Complanati
24 parts of 60 parts of nanometer Cortex Cinnamomis of 42 portions of nanometer Semen Euryaless of nanometer Semen Allii Tuberosi
36 parts of 36 parts of nanometer Radix Polygalaes of 30 parts of nano Porias of nanometer Fructus Foeniculi
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano kindey-benefiting preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano kindey-benefiting preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102064 CN1366923A (en) | 2001-01-22 | 2001-01-22 | Nano kindey-benefiting preparation medicine and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102064 CN1366923A (en) | 2001-01-22 | 2001-01-22 | Nano kindey-benefiting preparation medicine and preparation method |
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| CN1366923A true CN1366923A (en) | 2002-09-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103798670A (en) * | 2014-03-07 | 2014-05-21 | 王瑛 | Deep processing process of abelmoschus esculentus by nano technology |
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2001
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103798670A (en) * | 2014-03-07 | 2014-05-21 | 王瑛 | Deep processing process of abelmoschus esculentus by nano technology |
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