CN1363341A - Nano medicine 'Jiuwei Qianghuo' and its preparing process - Google Patents
Nano medicine 'Jiuwei Qianghuo' and its preparing process Download PDFInfo
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- CN1363341A CN1363341A CN 01100779 CN01100779A CN1363341A CN 1363341 A CN1363341 A CN 1363341A CN 01100779 CN01100779 CN 01100779 CN 01100779 A CN01100779 A CN 01100779A CN 1363341 A CN1363341 A CN 1363341A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000008713 qiang-huo Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000758794 Asarum Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 241000125175 Angelica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 241001180876 Saposhnikovia Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 239000011858 nanopowder Substances 0.000 abstract description 3
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000229179 Ledebouriella Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010063659 Aversion Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nano medicine "Jiuwei Qianghuo" is prepared from the nano powders of 9 Chinese-medicinal materials including notopterygium root, ledebouriella root, atractylodes rhizome, asarum herb, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of nano medicine ' Jiuwei Qianghuo ' of the dehumidifying of inducing sweat, the invention still further relates to the method for this medication preparation.
Notopterygii Bolus of Nine Ingredients is a kind of classical Chinese patent medicine, mainly contains the dehumidifying of inducing sweat and waits effect, is used for fever with aversion to cold, lossless, the diseases such as xerostomia, limb aching pain of having a headache.But traditional Notopterygii Bolus of Nine Ingredients absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Jiuwei Qianghuo ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Jiuwei Qianghuo '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Et Radix Notopterygii 100-250 part nanometer Radix Saposhnikoviae 100-200 part nanometer Rhizoma Atractylodis 100-200 part
Nanometric Herbra Asarum 30-80 part nanometer Rhizoma Chuanxiong 60-140 part nano angelica root 60-140 part
Nano astragalus 60-140 part nanometer Radix Glycyrrhizae 60-140 part nanometer Radix Rehmanniae 60-140 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Et Radix Notopterygii 120-180 part nanometer Radix Saposhnikoviae 120-180 part nanometer Rhizoma Atractylodis 120-180 part
Nanometric Herbra Asarum 40-60 part nanometer Rhizoma Chuanxiong 80-120 part nano angelica root 80-120 part
Nano astragalus 80-120 part nanometer Radix Glycyrrhizae 80-120 part nanometer Radix Rehmanniae 80-120 part
The optimum weight proportioning of medicine of the present invention is:
150 parts of 150 parts of nanometer Rhizoma Atractylodis of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Et Radix Notopterygii
100 parts of 100 parts of nano angelica roots of 50 parts of nanometer Rhizoma Chuanxiongs of nanometric Herbra Asarum
100 parts of 100 parts of nanometer Radix Rehmanniae of 100 parts of nanometer Radix Glycyrrhizaes of nano astragalus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Jiuwei Qianghuo ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Jiuwei Qianghuo ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Notopterygii Bolus of Nine Ingredients preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Jiuwei Qianghuo ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for fever with aversion to cold, lossless, the treatment of conditions such as xerostomia, limb aching pain of having a headache, and clinical efficacy significantly is better than traditional Notopterygii Bolus of Nine Ingredients.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
150 parts of 150 parts of nanometer Rhizoma Atractylodis of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Et Radix Notopterygii
100 parts of 100 parts of nano angelica roots of 50 parts of nanometer Rhizoma Chuanxiongs of nanometric Herbra Asarum
100 parts of 100 parts of nanometer Radix Rehmanniae of 100 parts of nanometer Radix Glycyrrhizaes of nano astragalus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
150 parts of 150 parts of nanometer Rhizoma Atractylodis of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Et Radix Notopterygii
100 parts of 100 parts of nano angelica roots of 50 parts of nanometer Rhizoma Chuanxiongs of nanometric Herbra Asarum
100 parts of 100 parts of nanometer Radix Rehmanniae of 100 parts of nanometer Radix Glycyrrhizaes of nano astragalus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer nine ingredients containing notopterygium powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
150 parts of 150 parts of nanometer Rhizoma Atractylodis of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Et Radix Notopterygii
100 parts of 100 parts of nano angelica roots of 50 parts of nanometer Rhizoma Chuanxiongs of nanometric Herbra Asarum
100 parts of 100 parts of nanometer Radix Rehmanniae of 100 parts of nanometer Radix Glycyrrhizaes of nano astragalus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer nine ingredients containing notopterygium membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Jiuwei Qianghuo ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Et Radix Notopterygii 100-250 part nanometer Radix Saposhnikoviae 100-200 part nanometer Rhizoma Atractylodis 100-200 part
Nanometric Herbra Asarum 30-80 part nanometer Rhizoma Chuanxiong 60-140 part nano angelica root 60-140 part
Nano astragalus 60-140 part nanometer Radix Glycyrrhizae 60-140 part nanometer Radix Rehmanniae 60-140 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Jiuwei Qianghuo ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Et Radix Notopterygii 120-180 part nanometer Radix Saposhnikoviae 120-180 part nanometer Rhizoma Atractylodis 120-180 part
Nanometric Herbra Asarum 40-60 part nanometer Rhizoma Chuanxiong 80-120 part nano angelica root 80-120 part
Nano astragalus 80-120 part nanometer Radix Glycyrrhizae 80-120 part nanometer Radix Rehmanniae 80-120 part
3, nano medicine ' Jiuwei Qianghuo ' according to claim 1, wherein the weight proportion of each nano raw material is:
150 parts of 150 parts of nanometer Rhizoma Atractylodis of 150 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Et Radix Notopterygii
100 parts of 100 parts of nano angelica roots of 50 parts of nanometer Rhizoma Chuanxiongs of nanometric Herbra Asarum
100 parts of 100 parts of nanometer Radix Rehmanniae of 100 parts of nanometer Radix Glycyrrhizaes of nano astragalus
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Jiuwei Qianghuo 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Jiuwei Qianghuo 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100779 CN1363341A (en) | 2001-01-09 | 2001-01-09 | Nano medicine 'Jiuwei Qianghuo' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100779 CN1363341A (en) | 2001-01-09 | 2001-01-09 | Nano medicine 'Jiuwei Qianghuo' and its preparing process |
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| Publication Number | Publication Date |
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| CN1363341A true CN1363341A (en) | 2002-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100779 Pending CN1363341A (en) | 2001-01-09 | 2001-01-09 | Nano medicine 'Jiuwei Qianghuo' and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988576A (en) * | 2012-10-08 | 2013-03-27 | 卞毓平 | Preparation method and application of nine-ingredient notopterygium root tablets |
| CN104474492A (en) * | 2014-11-19 | 2015-04-01 | 徐秀杰 | Traditional Chinese medicine composition for treating externally contracted wind evil and preparation method |
| CN105031565A (en) * | 2015-06-28 | 2015-11-11 | 李先强 | Traditional Chinese medicine for treating Middle East respiratory syndrome |
-
2001
- 2001-01-09 CN CN 01100779 patent/CN1363341A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988576A (en) * | 2012-10-08 | 2013-03-27 | 卞毓平 | Preparation method and application of nine-ingredient notopterygium root tablets |
| CN104474492A (en) * | 2014-11-19 | 2015-04-01 | 徐秀杰 | Traditional Chinese medicine composition for treating externally contracted wind evil and preparation method |
| CN105031565A (en) * | 2015-06-28 | 2015-11-11 | 李先强 | Traditional Chinese medicine for treating Middle East respiratory syndrome |
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