CN1360892A - Dry mixed suspension of Meptin and pseudoephe and its prepn - Google Patents
Dry mixed suspension of Meptin and pseudoephe and its prepn Download PDFInfo
- Publication number
- CN1360892A CN1360892A CN 00136032 CN00136032A CN1360892A CN 1360892 A CN1360892 A CN 1360892A CN 00136032 CN00136032 CN 00136032 CN 00136032 A CN00136032 A CN 00136032A CN 1360892 A CN1360892 A CN 1360892A
- Authority
- CN
- China
- Prior art keywords
- parts
- essence
- mannitol
- numb
- pseudo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 9
- FKNXQNWAXFXVNW-WBMJQRKESA-N procaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@H](O)[C@H](NC(C)C)CC FKNXQNWAXFXVNW-WBMJQRKESA-N 0.000 title 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims abstract description 15
- -1 hydroxypropyl methyl cellose Chemical compound 0.000 claims abstract description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 8
- 229930195725 Mannitol Natural products 0.000 claims abstract description 8
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 8
- 239000000594 mannitol Substances 0.000 claims abstract description 8
- 235000010355 mannitol Nutrition 0.000 claims abstract description 8
- 229960005489 paracetamol Drugs 0.000 claims abstract description 8
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 claims abstract description 6
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims description 7
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 229960001985 dextromethorphan Drugs 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 229960003908 pseudoephedrine Drugs 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 235000019640 taste Nutrition 0.000 abstract description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 abstract 1
- 229960003291 chlorphenamine Drugs 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 239000000686 essence Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 229940013618 stevioside Drugs 0.000 abstract 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 abstract 1
- 235000019202 steviosides Nutrition 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 229940124579 cold medicine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000009748 deglutition Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000938 histamine H1 antagonist Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The mixed suspension for treating cold is prepared with paracetamol, tussaphed, dextromethorphan hydrobromide, chlorpheniramine, Stevioside, hydroxypropyl methyl cellose, fine silicon gel powder, essence and mannitol. It has the features of fast digestion speed and fast absorption and thus high cold treating effect. I may be taken directly or after being dissolved in water. It looks good and tastes good and is especially suitable for old people and children.
Description
The present invention relates to a kind of U.S.A for the treatment of flu and pounce on pseudo-numb dry suspension and processing technology.
At present in numerous treatment cold medicines, in the majority at the medicine of a certain symptom treatment of flu, and certain limitation is all arranged, the medicament of pouncing on pseudo-numb sheet prescription with U.S.A can not be brought into play the synergism between the medicine effectively, thereby influences the therapeutic effect of medicament.
The purpose of this invention is to provide a kind of synergism between the medicine of giving full play to, and compound recipe U.S.A of treatment flu better effects if pounces on pseudo-numb dry suspension and processing technology.
For achieving the above object, technical scheme of the present invention is: a kind of U.S.A pounces on pseudo-numb dry suspension, is made by ratio of weight and the number of copies by following medicament:
32.5 parts of acetaminophen
3 parts of pseudoephedrine hydrochlorides
1.5 parts of dextromethorphan hydrobromides
0.2 part of chlorphenamine maleate
5 parts of steviosin
2 parts of hydroxypropyl emthylcelluloses
2 parts of micropowder silica gels
1 part in essence
103 parts in mannitol
Its processing technology is: get raw material and dried adjuvant and cross 80 mesh sieves respectively, wherein essence does not need drying, with above-mentioned amount chlorphenamine maleate and dextromethorphan hydrobromide equivalent incremental method mixing, again respectively with the abundant mix homogeneously of pseudoephedrine hydrochloride, acetaminophen, micropowder silica gel, hydroxypropyl emthylcellulose, steviosin and essence, add the abundant mix homogeneously of mannitol at last.
Reasonable recipe of the present invention, drug effect is definite, and acetaminophen is an antipyretic analgesic in the prescription, by suppressing prostaglandin synthetase, reduces prostaglandin and synthesizes and the generation antipyretic effect; Pseudoephedrine hydrochloride is an adrenomimetic, collapsible nasal mucosa vessels; Dextromethorphan hydrobromide is a cough medicine, produces antitussive effect by suppressing the oblongata coughing centre; Chlorphenamine maleate is H
1Receptor antagonist can increase Marjoram Extract and capillary permeability that antihistamine is caused; Hydroxypropyl emthylcellulose is as suspending agent, and it does not have influence to assay; Steviosin and essence are as correctives; Micropowder silica gel can improve the flowability of this product as fluidizer, thereby is convenient to packing, controls content uniformity better; Mannitol is as filler, and its nothing is drawn moist, and melting is also fine, and its aqueous solution good mouthfeel.It is fast that this dosage form has dissolution rate, absorbs characteristics rapidly, can give full play to the synergism between each medicine, the treatment flu is effective, drinks in the water soluble, also can directly take, have the good characteristics of color and taste tool, be convenient to the not good patient of old age, child and function of deglutition and use.
Embodiment
A kind of U.S.A pounces on pseudo-numb dry suspension, presses the lek number and feeds intake:
Acetaminophen 325g
Pseudoephedrine hydrochloride 30g
Dextromethorphan hydrobromide 15g
Chlorphenamine maleate 2g
Steviosin 50g
Hydroxypropyl emthylcellulose 20g
Micropowder silica gel 20g
Essence 10g
At last with mannitol to 1500g
Its processing technology is: get raw material and dried adjuvant and cross 80 mesh sieves respectively, wherein essence does not need drying, with above-mentioned amount chlorphenamine maleate and dextromethorphan hydrobromide equivalent incremental method mixing, again respectively with the abundant mix homogeneously of pseudoephedrine hydrochloride, acetaminophen, micropowder silica gel, hydroxypropyl emthylcellulose, steviosin and essence, add the abundant mix homogeneously of mannitol at last, make 100 bags of finished products, every bag 1.5 gram, warm boiled water, three times on the one, each 1-2 bag.
Claims (2)
1, a kind of U.S.A pounces on pseudo-numb dry suspension, it is characterized in that it is made by ratio of weight and the number of copies by following medicament:
32.5 parts of acetaminophen
3 parts of pseudoephedrine hydrochlorides
1.5 parts of dextromethorphan hydrobromides
0.2 part of chlorphenamine maleate
5 parts of steviosin
2 parts of hydroxypropyl emthylcelluloses
2 parts of micropowder silica gels
1 part in essence
103 parts in mannitol
2, U.S.A according to claim 1 pounces on the processing technology of pseudo-numb dry suspension, it is characterized in that getting raw material and dried adjuvant and cross 80 mesh sieves respectively, wherein essence does not need drying, with above-mentioned amount chlorphenamine maleate and dextromethorphan hydrobromide equivalent incremental method mixing, again respectively with the abundant mix homogeneously of pseudoephedrine hydrochloride, acetaminophen, micropowder silica gel, hydroxypropyl emthylcellulose, steviosin and essence, add the abundant mix homogeneously of mannitol at last.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136032 CN1360892A (en) | 2000-12-28 | 2000-12-28 | Dry mixed suspension of Meptin and pseudoephe and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136032 CN1360892A (en) | 2000-12-28 | 2000-12-28 | Dry mixed suspension of Meptin and pseudoephe and its prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1360892A true CN1360892A (en) | 2002-07-31 |
Family
ID=4597038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00136032 Pending CN1360892A (en) | 2000-12-28 | 2000-12-28 | Dry mixed suspension of Meptin and pseudoephe and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1360892A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493503C (en) * | 2006-10-24 | 2009-06-03 | 浙江康德药业集团有限公司 | Taste masked dry suspension for treating infant cold and method for preparing same |
| CN101596157A (en) * | 2008-06-04 | 2009-12-09 | 北京科信必成医药科技发展有限公司 | The compound slow release preparation of a kind of pseudoephedrine, chlorphenamine and dextromethorphan |
| CN102657616A (en) * | 2012-04-30 | 2012-09-12 | 青岛国海生物制药有限公司 | Paracetamol dry suspension for treating common cold in children |
| CN103127113A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| CN107929243A (en) * | 2017-12-11 | 2018-04-20 | 河南惠通天下生物工程有限公司 | A kind of thiabendazolum dry suspensoid agent and preparation method thereof |
-
2000
- 2000-12-28 CN CN 00136032 patent/CN1360892A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493503C (en) * | 2006-10-24 | 2009-06-03 | 浙江康德药业集团有限公司 | Taste masked dry suspension for treating infant cold and method for preparing same |
| CN101596157A (en) * | 2008-06-04 | 2009-12-09 | 北京科信必成医药科技发展有限公司 | The compound slow release preparation of a kind of pseudoephedrine, chlorphenamine and dextromethorphan |
| CN102657616A (en) * | 2012-04-30 | 2012-09-12 | 青岛国海生物制药有限公司 | Paracetamol dry suspension for treating common cold in children |
| CN103127113A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| CN103127113B (en) * | 2013-02-19 | 2014-07-30 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| CN107929243A (en) * | 2017-12-11 | 2018-04-20 | 河南惠通天下生物工程有限公司 | A kind of thiabendazolum dry suspensoid agent and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |