CN1358841A - Yunnan streptin - Google Patents
Yunnan streptin Download PDFInfo
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- CN1358841A CN1358841A CN 00134062 CN00134062A CN1358841A CN 1358841 A CN1358841 A CN 1358841A CN 00134062 CN00134062 CN 00134062 CN 00134062 A CN00134062 A CN 00134062A CN 1358841 A CN1358841 A CN 1358841A
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Abstract
The present invention relates to the field of microbiological technology, in particular it relates to a new actinomycetes. Said invention is a streptomyces yunnanensis, its preserved registration number is CGMCC No.0509. Said invented actinomycetes can utilize microbiological fermentation and liquid phase chromatographic preparation method to obtain new optical type cycloheximides compound. Said compound possesses strong antifungal activity, and its yield rate can be up to 0.04%.
Description
The present invention relates to microbial technology field, specifically relate to novel species actinomycetes.
The cycloheximide compounds, has anti-mycotic activity, this compounds mainly is to obtain by the microbial fermentation approach, and being widely used in a plurality of fields such as agricultural antibiotic, the biochemical and medical manufacturing of experiment, existing cycloheximide compounds (as actidione) mainly is to obtain by the microbial fermentation approach.Along with the understanding of the mankind, need this compounds of more anti-various fungies to fungi.
The purpose of this invention is to provide a kind of novel species actinomycetes---Yunnan streptin that can produce new cycloheximide compounds with anti-mycotic activity.
Yunnan streptin of the present invention, its called after Yunnan streptin (streptomycesyunnanensis), its preservation registration number is CGMCC NO.0509.
Gather in the laterite of Yunnan streptin system of the present invention by suburb, Kunming, Yunnan, obtain in the laboratory separation and Culture, this bacterial strain is in the preservation of specified depositary institution of Patent Office of State Intellectual Property Office, and preservation date is on November 19th, 2000, and preservation registration number is CGMCC NO.0509.The morphological specificity of bacterial strain is that gas silk and base silk are flourishing, and the base silk does not rupture; Spore chain length, twist; Many wrinkles in spore (diameter 0.5-10 μ m) surface and the short thorn of band.Cytochemistry: cell walls contains LL-DAP and glycine: full cell hydrolyzed solution contains semi-lactosi.
Culture condition:
(1) slant culture: cultivated 7 days.Substratum: glucose 1-5g, yeast extract paste 1-5g, malt extract 1-5g, vitamin complex 3.75mg/L, agar 15-20g, distilled water 1000ml, PH7.2;
(2) seed culture: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 50-160g, soyflour 10-50g, yeast extract paste 0.5-5g, tryptophane 0.1-2g, Beta-alanine 1-6g, sal epsom 0.1-2g, ammonium phosphate 0.1-2g, distilled water 1000ml, PH7.2:
(3) fermentation: the inoculum size by 10% inserts in the seed culture medium, shake-flask culture 6 days.Substratum: soyflour 1-20g, glucose 1-25g, peptone 1-10, sodium-chlor 0.1-5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
16SrDNA：ataccttgttacgacttcgtcccaatcgccagtcccaccttcgacgattccctcccacaaggggttgggccaccggcttcgggtgttaccgactttcgtgacgtgacgggcggtgtgtacaaggcccgggaacgtattcaccgcagcaatgctgatctgcgattactagcaactccgacttcatggggtcgagttgcagaccccaatccgaactgagaccggctttttgagattcgctccacctcgcggtatcgcagctcattgtaccggccattgtagcacgtgtgcagcccaagacataaggggcatgatgacttgacgtcgtccccaccttcctccgagttgaccccggcagtctcctgtgagtccccatcaccccgaaaggcatgctggcaacacagaacaagggttgcgctcgttgcgggacttaacccaacatctcacgacacgagctgacgacagccatgcaccacctgtacaccgaccacaagggggaccctatctctaatgctttccggtgtatgtcaagccttggtaaggttcttcgcgttgcgtcgaattaagccacatgctccgatgcttgtgcgggcccccgtcaattcctttgagttttagccttgcggccgtactccccaggcggggaacttaatgcgttagctgcggcacggacgacgtggaatgtcgcccacacctagttcccaacgtttacggcgtggactaccagggtatctaatcctgttcgctccccacgctttcgctcctcagcgtcagtatcggcccagagatccgccttcgccaccggtgttcctcctgatatctgcgcatttcaccgctacaccaggaattccgatctcccctaccgaactctagcctgcccgtatcgaatgcagacccggggttaagccccgggctttcacatccgacgtgacaagccgcctacgagctctttacgcccaataattccggacaacgctcgcgccctacgtattaccgcggctgctggcacgtagttagccggcgcttcttctgcaggtaccgtcactctcgcttcttccctgctgaaagaggtttacaacccgaaggccgtcatccctcacgcggcgtcgctgcatcaggctttcgcccattgtgcaatattccccactgctgcctcccgtaggagtctgggccgtgtctcagtcccagtgtggccggtcgccctctcaggccggctacccgtcgtcgccttggtgagccattacctcaccaacaagctgataggccgcgggctcatccttcaccgccggagctttccacacggagatcatgcgaccccgtgtcatatccggtattagaccccgtttccagggcttgtcccagagtgaagggcagattgccctcgtgttactcacccgttcgccactaatccccgaccgaagccggttcatcgttcgacttgcatgtgttaagcacgccgccagcgttcgtcctgagccaggatcaaactctgagctcgt
Fig. 1 is the bacterial strain stereoscan photograph of microorganism of the present invention.
Fig. 2 is the local magnified sweep electromicroscopic photograph of the bacterial strain of microorganism of the present invention.
Fig. 1 has shown the state of Yunnan streptin bacterial strain spore chain of the present invention, and what Fig. 2 was shown is bacterial strain The careful outward appearance of single spore on the spore chain is if any elephant skin and have short thorn.
Yunnan streptin of the present invention is novel species actinomyces, it can pass through the microbial fermentation approach, The cycloheximide compounds that the method for preparing liquid chromatography acquisition has new optically-active type, such that obtains Compound is noval chemical compound; Has strong antifungal activity, the change that utilizes microorganism of the present invention to obtain Compound productive rate height can reach 0.04 ‰.
Embodiment:
From the laterite in suburb, Kunming, Yunnan, gather soil sample, in the laboratory, cultivate, can obtain actinomycetes strain Yunnan streptin YIM41004 of the present invention by following condition.
Culture condition:
(1) slant culture condition: substratum: glucose 4g, yeast extract paste 4g, malt extract 5g, vitamin complex 3.75mg/L, agar 15g, distilled water 1000ml, PH7.2; Cultivated 7 days;
(2) seed culture condition: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 120g, soyflour 40g, yeast extract paste 2g, tryptophane 0.5g, Beta-alanine 5g, sal epsom 0.5g, ammonium phosphate 0.2g, distilled water 1000ml, PH7.2;
(3) fermentation culture conditions: receive in the seed culture medium shake-flask culture 6 days by 10% inoculum size.Substratum: soyflour 10g, glucose 10g, peptone 3g, sodium-chlor 2.5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
Claims (3)
1, a kind of Yunnan streptin is characterized in that called after Yunnan streptin (streptomycesyunnanensis), and its preservation registration number is CGMCC NO.0509.
2,, it is characterized in that culture condition is according to the described Yunnan streptin of claim 1:
(1) slant culture: cultivated 7 days.Substratum: glucose 1-5g, yeast extract paste 1-5g, malt extract 1-5g, vitamin complex 3.75mg/L, agar 15-20g, distilled water 1000ml, PH7.2;
(2) seed culture: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 50-160g, soyflour 10-50g, yeast extract paste 0.5-5g, tryptophane 0.1-2g, Beta-alanine 1-6g, sal epsom 0.1-2g, ammonium phosphate 0.1-2g, distilled water 1000ml, PH7.2;
(3) fermentation: the inoculum size by 10% inserts in the seed culture medium, shake-flask culture 6 days.Substratum: soyflour 1-20g, glucose 1-25g, peptone 1-10, sodium-chlor 0.1-5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
3、1,16SrDNA：ataccttgttacgacttcgtcccaatcgccagtcccaccttcgacgattccctcccacaaggggttgggccaccggcttcgggtgttaccgactttcgtgacgtgacgggcggtgtgtacaaggcccgggaacgtattcaccgcagcaatgctgatctgcgattactagcaactccgacttcatggggtcgagttgcagaccccaatccgaactgagaccggctttttgagattcgctccacctcgcggtatcgcagctcattgtaccggccattgtagcacgtgtgcagcccaagacataaggggcatgatgacttgacgtcgtccccaccttcctccgagttgaccccggcagtctcctgtgagtccccatcaccccgaaaggcatgctggcaacacagaacaagggttgcgctcgttgcgggacttaacccaacatctcacgacacgagctgacgacagccatgcaccacctgtacaccgaccacaagggggaccctatctctaatgctttccggtgtatgtcaagccttggtaaggttcttcgcgttgcgtcgaattaagccacatgctccgatgcttgtgcgggcccccgtcaattcctttgagttttagccttgcggccgtactccccaggcggggaacttaatgcgttagctgcggcacggacgacgtggaatgtcgcccacacctagttcccaacgtttacggcgtggactaccagggtatctaatcctgttcgctccccacgctttcgctcctcagcgtcagtatcggcccagagatccgccttcgccaccggtgttcctcctgatatctgcgcatttcaccgctacaccaggaattccgatctcccctaccgaactctagcctgcccgtatcgaatgcagacccggggttaagccccgggctttcacatccgacgtgacaagccgcctacgagctctttacgcccaataattccggacaacgctcgcgccctacgtattaccgcggctgctggcacgtagttagccggcgcttcttctgcaggtaccgtcactctcgcttcttccctgctgaaagaggtttacaacccgaaggccgtcatccctcacgcggcgtcgctgcatcaggctttcgcccattgtgcaatattccccactgctgcctcccgtaggagtctgggccgtgtctcagtcccagtgtggccggtcgccctctcaggccggctacccgtcgtcgccttggtgagccattacctcaccaacaagctgataggccgcgggctcatccttcaccgccggagctttccacacggagatcatgcgaccccgtgtcatatccggtattagaccccgtttccagggcttgtcccagagtgaagggcagattgccctcgtgttactcacccgttcgccactaatccccgaccgaagccggttcatcgttcgacttgcatgtgttaagcacgccgccagcgttcgtcctgagccaggatcaaactctgagctcgt
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| CN 00134062 CN1358841A (en) | 2000-12-11 | 2000-12-11 | Yunnan streptin |
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| CN 00134062 CN1358841A (en) | 2000-12-11 | 2000-12-11 | Yunnan streptin |
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