CN1339312A - Wound plaster of yannan Baiyao and its preparing method - Google Patents
Wound plaster of yannan Baiyao and its preparing method Download PDFInfo
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- CN1339312A CN1339312A CN 01128846 CN01128846A CN1339312A CN 1339312 A CN1339312 A CN 1339312A CN 01128846 CN01128846 CN 01128846 CN 01128846 A CN01128846 A CN 01128846A CN 1339312 A CN1339312 A CN 1339312A
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- baiyao
- wound
- wound plaster
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- 239000011505 plaster Substances 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 239000002390 adhesive tape Substances 0.000 claims abstract description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 238000005303 weighing Methods 0.000 claims description 15
- 239000000853 adhesive Substances 0.000 claims description 12
- 230000001070 adhesive effect Effects 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 239000004745 nonwoven fabric Substances 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 38
- 208000027418 Wounds and injury Diseases 0.000 abstract description 38
- 230000000694 effects Effects 0.000 abstract description 18
- 239000009306 yunnan baiyao Substances 0.000 abstract description 14
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract description 10
- 229940116229 borneol Drugs 0.000 abstract description 10
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract description 10
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract description 10
- 230000000740 bleeding effect Effects 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 230000008961 swelling Effects 0.000 abstract description 6
- 239000000843 powder Substances 0.000 abstract description 5
- 208000002193 Pain Diseases 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 230000036407 pain Effects 0.000 abstract description 4
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002994 raw material Substances 0.000 description 14
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 230000023597 hemostasis Effects 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 206010042674 Swelling Diseases 0.000 description 5
- 230000036592 analgesia Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000001637 borneol derivatives Chemical class 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention is one new preparation from of Yunnan Baiyao. The wound plaster of Yunnan Baiyao includes medicine, adhesive tape and medicine core and features the medicine components comprising Yunnan Baiyao powder, Tween-80, borneol and water. Compared with available wound plaster, the present invention has fast and high wound curing effect owing to the functions of promoting blood circulation to disperse blood clots, eliminating swelling, stopping pain, stopping bleeding and wound curing of Yunnan Baiyao.
Description
One, technical field
The invention belongs to the technical field of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation of patch form.
Two, background technology
Commercially available YUNNAN BAIYAO is a kind of evident in efficacy now, the traditional famous medicine that has won fame both at home and abroad, formulated in 1902, clinical verification through a century, confirmed that it has the effect of hemostasis wound healing, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, be used for traumatic injury, swelling and pain due to blood stasis, haematemesis, hemoptysis, have blood in stool, disease such as ulcerative hemorrhage, determined curative effect.But, because YUNNAN BAIYAO is a kind of traditional powder, in the life-time service process, the part that comes with some shortcomings, when using such as the patient, each consumption is difficult to grasp, when being used in particular for the little wound of wound, very inconvenient, YUNNAN BAIYAOFEN can not spread on wound surface effectively, so that does not bring into play the curative effect of YUNNAN BAIYAO well.
Three, summary of the invention
1. the object of the present invention is to provide a kind of Wound plaster of yannan Baiyao, i.e. the YUNNAN BAIYAO novel form of patch form, this patch determined curative effect, easy to use.Simultaneously, the present invention also provides the preparation method of Wound plaster of yannan Baiyao.
2. technical scheme of the present invention
(1) consisting of of Wound plaster of yannan Baiyao medicament: YUNNAN BAIYAOFEN 65 grams～105 grams, tween 80 0.5 gram～1.5 grams, Borneolum Syntheticum 0.6 gram～1.0 grams, 1200 Wound plaster of yannan Baiyao of 70 milliliters-130 milliliters preparations of water; Packaging material: 1. adhesive tape: adopt PVP adhesive tape or elastic force cloth or zinc oxide adhesive plaster or PU adhesive tape; 2. medicated core: the macromolecule isolating membrane adds non-woven fabrics or the macromolecule isolating membrane adds textile ribbon or nethike embrane non-woven fabrics.
(2) preparation method of Wound plaster of yannan Baiyao may further comprise the steps:
1. take by weighing Borneolum Syntheticum 0.6 gram～1.0 grams, 80 milliliters～120 milliliters of the ethanol of adding 75%～95% make it abundant dissolving, make Borneolum Syntheticum liquid, and are stand-by;
2. take by weighing YUNNAN BAIYAOFEN 65 grams～105 grams, use 320 milliliters～360 milliliters of 40%～80% ethanol at every turn, extract repeatedly 2～6 times, reclaim the extractum that ethanol obtains 1.05～1.20/25 ℃ of proportions;
3. take by weighing extractum 10 grams～27 grams, add tween 80 0.5 gram～1.5 grams, add 70 milliliters～130 milliliters in water, dissolving evenly slowly by in the above-mentioned solution, is pushed medicated core, 50 ℃～110 ℃ following tumble dried, the medicated core that drying is good is installed on the equipment, slowly passes through equipment, spray the Borneolum Syntheticum liquid that has prepared, make per 100 square centimeters to contain 2.4 milliliters of Borneolum Syntheticums, cut rewinding, packing gets product.Specification: 47 centimetres of 6.0 centimetres of 2.3 centimetres of 1.5 cm x or 4.5 cm x or 2.5 cm x.
(3) usage and dosage:
The cleaning wound surface is taken Wound plaster of yannan Baiyao off from anti-viscose paper, allows the medicine ribbon be affixed on wound surface, and degree of tightness suitably gets final product.
(4) storage: airtight, put shady and cool dry place and preserve.
3. beneficial effect
Compare with existing general adhesive bandage, the present invention has the effect of following uniqueness:
(1) can fully keep and bring into play the YUNNAN BAIYAO blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the conventional medicament effect of hemostasis wound healing is to hemostasis, analgesia, the antiinflammatory of little wound, wound healing is respond well, and cure rate is 100%, and easy to carry, onset is rapid, determined curative effect, and untoward reaction is not seen in clinical use.
(2) in clinical practice, the Wound plaster of yannan Baiyao of big specification can be used for wound behind the operation stitching, can impel wound healing after operation to accelerate.Because YUNNAN BAIYAOFEN has blood circulation promoting and blood stasis dispelling, the effect of granulation promoting can make wound recover smooth.
Four, effect experiment
Confirm that through pharmacological evaluation Wound plaster of yannan Baiyao has the more effect of wound of hemostatic analgesia, antiinflammatory.
1, hemostasis: the Wound plaster of yannan Baiyao crude drug can shorten mice and cut the tail bleeding time, reduces amount of bleeding, and can significantly strengthen the maximum aggregation intensity of platelet, sees Table 1, table 2
Table 1. Wound plaster of yannan Baiyao raw material is to the influence of mice bleeding time and amount of bleeding
| Group | Number of animals | Bleeding time min (X ± SD) | Light transmittance % (X ± SD) |
| Matched group | ????20 | ????6.49±2.94 | ??24.58±21.86 |
| Adhesive bandage raw material high dose | ????20 | ????2.92±2.79 ** | ??72.78±32.89 ** |
| Adhesive bandage raw material low dosage | ????20 | ????3.92±2.56 ** | ??47.66±34.93 ** |
| The YUNNAN BAIYAO suspension | ????20 | ????3.28±2.78 ** | ??62.52±33.30 ** |
The t-check
*P＜0.01
Table 2. Yunnan adhesive bandage raw material is to the influence of the maximum aggregation intensity of tame rabbit platelet
| Group | The example number | The maximum aggregation intensity % of platelet (X ± SD) |
| Matched group | ????6 | ????24.26±11.05 |
| Adhesive bandage raw material high dose | ????6 | ????88.02±10.42 ** |
| Adhesive bandage raw material low dosage | ????6 | ????70.45±9.67 ** |
The t-check
*P＜0.01
2, analgesia: the Wound plaster of yannan Baiyao raw material can reduce obviously that injected in mice causes that pain back produces turns round the body number of times, has analgesic activity.See Table 3
Table 3. YUNNAN BAIYAO raw material is to the influence of mice after with algogen
| Group | Number of animals | The mouse writhing number of times (X ± SD) |
| Matched group | ?????10 | ??????50.4±5.7 |
| Adhesive bandage raw material high dose | ?????10 | ??????32.0±18.4 * |
| Adhesive bandage raw material low dosage | ?????10 | ??????30.8±12.7 ** |
| Positive control | ?????10 | ??????29.6±12.7 ** |
The t-check
*P＜0.05
*P＜0.01
3, antiinflammatory: the Wound plaster of yannan Baiyao raw material can obviously resist dimethylbenzene induced mice auricle edema, and stronger antiinflammatory action is arranged.See Table 4
Table 4. Wound plaster of yannan Baiyao raw material is to the influence of mice auricle swelling
| Group | Number of animals | Swelling degree % (X ± SD) |
| Matched group | ????10 | ?????0.55±0.30 |
| Adhesive bandage raw material high dose | ????10 | ?????0.13±0.08 * |
| Adhesive bandage raw material low dosage | ????10 | ?????0.18±0.16 * |
| Acetyl salicylic acid | ????10 | ?????0.17±0.07 ** |
The t-check
*P＜0.05
4, after Wound plaster of yannan Baiyao contacts the animal damaged skin, observe wound hemostasis, redness is oozed out and bonding situation, matched group and administration group have significant difference through Ridit method check P＜0.01, illustrate that Wound plaster of yannan Baiyao has preferably more creation to use to damaged skin.
The Wound plaster of yannan Baiyao toxicological experiment:
Wound plaster of yannan Baiyao heavy dose (23mg/ sheet) and low dose of (8mg/ sheet) outer time spent, rabbit intact skin and damaged skin are not all caused toxic reaction.Clinical observation:
Unite through the attached First Academy of unming Medical College, Annex II institute of unming Medical College, Yunnan Province Red Cross Hospital and to have carried out 240 routine clinical observations (160 examples are organized in treatment, matched group 80 examples) confirm, Wound plaster of yannan Baiyao treatment minor cut or wound has significant curative effect, and total effective rate reaches 100%.
1 Wound plaster of yannan Baiyao total effects observed result table
| Group | Case load | Cure | Produce effects | Effectively | Invalid | ????P | |
| Overall merit | The treatment group | ????160 | ???129(80.6％) | ???22(13.8％) | ??9(5.6％) | ??0(0％) | ??＜0.01 |
| Matched group | ????80 | ???42(52.5％) | ???18(22.5％) | ??16(20％) | ??4(5％) |
2 Wound plaster of yannan Baiyao are to hemostasis, analgesia, antiinflammatory, more create cardinal symptom observation of curative effect table as a result
| Group | Case load | Cure | Produce effects | Effectively | Invalid | ????P | |
| Hemostasis | The treatment group | ????160 | ????148(92.5％) | ??12(7.5％) | ????0(0) | ??0(0) | ??＜0.05 |
| Matched group | ????80 | ????58(72.5％) | ??22(27.5％) | ????0(0) | ??0(0) | ||
| Analgesia | The treatment group | ????160 | ????108(67.5％) | ??51(31.9％) | ??1(0.6％) | ??0(0) | ??＜0.05 |
| Matched group | ????80 | ????40(50％) | ??38(47.5％) | ??2(2.5％) | ??0(0) | ||
| Antiinflammatory | The treatment group | ????160 | ????128(80％) | ??26(16.2％) | ??6(3.8％) | ??0(0) | ??＜0.01 |
| Matched group | ????80 | ????35(43.8％) | ??28(35.5％) | ??12(15％) | ??5(6.2 ????％) | ||
| More create | The treatment group | ????160 | ????117(73.1％) | ??36(22.5％) | ??7(4.4％) | ??0(0) | ??＜0.01 |
| Matched group | ????80 | ????36(45％) | ??35(43.8％) | ??4(5％) | ??5(6.2 ????％) |
The curative effect statistical table of the wound of 3 Wound plaster of yannan Baiyao treatment different situations
| Group | Case load | Cure | Produce effects | Effectively | Invalid | ????P | ||
| The injured degree of depth | Epidermis | The treatment group | ????84 | ????74 | ????8 | ????2 | ????0 | ??＜0.01 |
| Matched group | ????49 | ????30 | ????11 | ????7 | ????1 | |||
| Holostrome and subcutaneous tissue | The treatment group | ????76 | ????52 | ????16 | ????8 | ????0 | ??＜0.05 | |
| Matched group | ????31 | ????14 | ????10 | ????7 | ????0 | |||
| Injured area | ??＜0.5× ??0.5cm 2 | The treatment group | ????70 | ????62 | ????5 | ????3 | ????0 | ??＜0.01 |
| Matched group | ????54 | ????30 | ???13 | ????8 | ????3 | |||
| ????＜1× ????1cm 2 | The treatment group | ????90 | ????67 | ???16 | ????7 | ????0 | ??＜0.01 | |
| Matched group | ????26 | ????7 | ???12 | ????7 | ????0 | |||
| Pollution condition | Pollute light | The treatment group | ????110 | ????90 | ???13 | ????7 | ????0 | ??＞0.05 |
| Matched group | ????63 | ????43 | ???7 | ????8 | ????5 | |||
| Pollute heavy | The treatment group | ????50 | ????24 | ???20 | ????6 | ????0 | ??＞0.05 | |
| Matched group | ????17 | ????6 | ???4 | ????7 | ????0 | |||
| The wound bleeding situation | No hemorrhage | The treatment group | ????53 | ????47 | ???3 | ????3 | ????0 | ??＞0.05 |
| Matched group | ????32 | ????23 | ???4 | ????5 | ????0 | |||
| Have hemorrhage | The treatment group | ????107 | ????81 | ???20 | ????6 | ????0 | ??＜0.01 | |
| Matched group | ????48 | ????16 | ???18 | ????10 | ????4 |
Five, the specific embodiment
Embodiment 1
Take by weighing borneol 0.6 gram, 80 milliliters of the ethanol of adding 75% make it abundant dissolving, make borneol liquid, and are stand-by; Take by weighing Yunnan Baiyao powder 65 gram, use 320 milliliters of 40% ethanol at every turn, repeatedly extract 2 times, Recycled ethanol obtains the medicinal extract of 1.05/25 ℃ of proportion; Take by weighing medicinal extract 10 grams, add Tween-80 0.5 gram, add 70 milliliters in water, dissolving evenly slowly by in the mentioned solution, is pushed the medicine core, 50 ℃ of lower tumble dried, the medicine core that drying is good is installed on the equipment, slowly passes through equipment, spray the borneol liquid that has prepared, make per 100 square centimeters to contain 2.4 milliliters of borneols, cut rewinding, packing gets product.
Embodiment 2
Take by weighing borneol 0.8 gram, 100 milliliters of the ethanol of adding 85% make it abundant dissolving, make borneol liquid, and are stand-by; Take by weighing Yunnan Baiyao powder 90 grams, use 340 milliliters of 60% ethanol at every turn, repeatedly extract 4 times, Recycled ethanol obtains the medicinal extract of 1.10/25 ℃ of proportion; Take by weighing medicinal extract 18 grams, add Tween-80 1 gram, add 110 milliliters in water, dissolving evenly slowly by in the mentioned solution, is pushed the medicine core, 80 ℃ of lower tumble dried, the medicine core that drying is good is installed on the equipment, slowly passes through equipment, spray the borneol liquid that has prepared, make per 100 square centimeters to contain 2.4 milliliters of borneols, cut rewinding, packing gets product.
Embodiment 3
Take by weighing borneol 1.0 grams, 120 milliliters of the ethanol of adding 95% make it abundant dissolving, make borneol liquid, and are stand-by; Take by weighing Yunnan Baiyao powder 105 grams, use 360 milliliters of 80% ethanol at every turn, repeatedly extract 6 times, Recycled ethanol obtains the medicinal extract of 1.20/25 ℃ of proportion; Take by weighing medicinal extract 27 grams, add Tween-80 1.5 grams, add 130 milliliters in water, dissolving evenly slowly by in the mentioned solution, is pushed the medicine core, 110 ℃ of lower tumble dried, the medicine core that drying is good is installed on the equipment, slowly passes through equipment, spray the borneol liquid that has prepared, make per 100 square centimeters to contain 2.4 milliliters of borneols, cut rewinding, packing gets product.
Claims (5)
1. a Wound plaster of yannan Baiyao comprises medicament, adhesive tape and medicated core, it is characterized in that consisting of of medicament: with YUNNAN BAIYAOFEN 65 grams～105 grams, tween 80 0.5 gram～1.5 grams, Borneolum Syntheticum 0.6 gram～1.0 grams, 1200 Wound plaster of yannan Baiyao of 70 milliliters-130 milliliters preparations of water.
2. Wound plaster of yannan Baiyao according to claim 1 is characterized in that adhesive tape adopts PVP adhesive tape or elastic force cloth or zinc oxide adhesive plaster or PU adhesive tape;
3. Wound plaster of yannan Baiyao according to claim 2 is characterized in that medicated core adopts the macromolecule isolating membrane to add non-woven fabrics or the macromolecule isolating membrane adds textile ribbon or nethike embrane non-woven fabrics.
4. Wound plaster of yannan Baiyao according to claim 3, the dimensions that it is characterized in that product are 47 centimetres of 2.3 centimetres of 1.5 cm x or 6.0 centimetres of 4.5 cm x or 2.5 cm x.
5. the preparation method of the described Wound plaster of yannan Baiyao of claim 1 may further comprise the steps:
1. take by weighing Borneolum Syntheticum 0.6 gram～1.0 grams, 80 milliliters～120 milliliters of the ethanol of adding 75%～95% make it abundant dissolving, make Borneolum Syntheticum liquid, and are stand-by;
2. take by weighing YUNNAN BAIYAOFEN 65 grams～105 grams, use 320 milliliters～360 milliliters of 40%～80% ethanol at every turn, extract repeatedly 2～6 times, reclaim the extractum that ethanol obtains 1.05～1.20/25 ℃ of proportions;
3. take by weighing extractum 10 grams～27 grams, add tween 80 0.5 gram～1.5 grams, add 70 milliliters～130 milliliters in water, dissolving evenly slowly by in the above-mentioned solution, is pushed medicated core, 50 ℃～110 ℃ following tumble dried, the medicated core that drying is good is installed on the equipment, slowly passes through equipment, spray the Borneolum Syntheticum liquid that has prepared, make per 100 square centimeters to contain 2.4 milliliters of Borneolum Syntheticums, cut rewinding, packing gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011288469A CN1136904C (en) | 2001-09-13 | 2001-09-13 | Wound plaster of yannan Baiyao and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011288469A CN1136904C (en) | 2001-09-13 | 2001-09-13 | Wound plaster of yannan Baiyao and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1339312A true CN1339312A (en) | 2002-03-13 |
| CN1136904C CN1136904C (en) | 2004-02-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011288469A Expired - Lifetime CN1136904C (en) | 2001-09-13 | 2001-09-13 | Wound plaster of yannan Baiyao and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103356827A (en) * | 2013-07-26 | 2013-10-23 | 重庆金老虎科技开发有限公司 | Cattail pollen adhesive bandage and preparation method thereof |
| CN107213198A (en) * | 2017-04-23 | 2017-09-29 | 广西大学 | A kind of many effect adhesive bandages |
| CN108653377A (en) * | 2018-07-04 | 2018-10-16 | 阿拉腾其木格 | A Mongolian medicine patch for treating skin wounds and its preparation method |
| CN111214694A (en) * | 2020-03-31 | 2020-06-02 | 山东大鱼生物技术有限公司 | Dressing with functions of stopping bleeding and accelerating wound healing and preparation method thereof |
| CN114832018A (en) * | 2022-04-06 | 2022-08-02 | 内蒙古自治区国际蒙医医院 | Mongolian medicine patch for treating and repairing skin wound and preparation method thereof |
-
2001
- 2001-09-13 CN CNB011288469A patent/CN1136904C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356827A (en) * | 2013-07-26 | 2013-10-23 | 重庆金老虎科技开发有限公司 | Cattail pollen adhesive bandage and preparation method thereof |
| CN107213198A (en) * | 2017-04-23 | 2017-09-29 | 广西大学 | A kind of many effect adhesive bandages |
| CN108653377A (en) * | 2018-07-04 | 2018-10-16 | 阿拉腾其木格 | A Mongolian medicine patch for treating skin wounds and its preparation method |
| CN111214694A (en) * | 2020-03-31 | 2020-06-02 | 山东大鱼生物技术有限公司 | Dressing with functions of stopping bleeding and accelerating wound healing and preparation method thereof |
| CN111214694B (en) * | 2020-03-31 | 2022-04-22 | 山东大鱼生物技术有限公司 | Dressing with functions of stopping bleeding and accelerating wound healing and preparation method thereof |
| CN114832018A (en) * | 2022-04-06 | 2022-08-02 | 内蒙古自治区国际蒙医医院 | Mongolian medicine patch for treating and repairing skin wound and preparation method thereof |
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| CN1136904C (en) | 2004-02-04 |
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