CN1325022C - Laser imaging apparatus using biomedical markes that bind to cancer cells - Google Patents
Laser imaging apparatus using biomedical markes that bind to cancer cells Download PDFInfo
- Publication number
- CN1325022C CN1325022C CNB998166081A CN99816608A CN1325022C CN 1325022 C CN1325022 C CN 1325022C CN B998166081 A CNB998166081 A CN B998166081A CN 99816608 A CN99816608 A CN 99816608A CN 1325022 C CN1325022 C CN 1325022C
- Authority
- CN
- China
- Prior art keywords
- target
- scanned
- detector
- laser beam
- track
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J9/00—Circuit arrangements for emergency or stand-by power supply, e.g. for emergency lighting
- H02J9/04—Circuit arrangements for emergency or stand-by power supply, e.g. for emergency lighting in which the distribution system is disconnected from the normal source and connected to a standby source
- H02J9/06—Circuit arrangements for emergency or stand-by power supply, e.g. for emergency lighting in which the distribution system is disconnected from the normal source and connected to a standby source with automatic change-over, e.g. UPS systems
- H02J9/062—Circuit arrangements for emergency or stand-by power supply, e.g. for emergency lighting in which the distribution system is disconnected from the normal source and connected to a standby source with automatic change-over, e.g. UPS systems for AC powered loads
Landscapes
- Business, Economics & Management (AREA)
- Emergency Management (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to a method for collecting data in the image reconstruction of scanned tissue which comprises tumour cells. The method comprises the following steps: a laser beam source 16 is provided; a biochemical marker which selectively restricts the tumour cells in the tissue is provided; laser beams are led to a scanned object 14; a laser beam 23 is used for encircling the object 14; a plurality of sensors 12 suitable for simultaneously detecting the laser beams which pass through the object 14; after the biochemical marker is activated, the sensors 12 are confined to only detect radiation released by the biochemical marker.
Description
Invention field
It is 60/036088 and 60/063590 that the application relates to serial number, is set forth in the provisional application on January 17th, 1997 and on October 30th, 1997 respectively, its this merged with reference to and its priority be required at this.
The application also relates to the United States Patent (USP) 5692511 that is proposed by Richard J.Grable, and it is merged reference at this.
Invention field
The application relates generally to use near-infrared laser to make the diagnostic medical imaging device of radiation source and is particularly related to the method and apparatus that uses biochemical marker, its optionally retrain tumor cell and when being energized, send be different from the device laser beam radiation so that the positive identification that is arranged in the image reconstruction tumor that is scanned tissue to be provided.
Background of invention
Breast carcinoma is the major causes of death in the American Women's population.Effective treatment of this disease is that major part is directly finished after the early discovery of malignant tumor.The main achievement that obtains at present provides a large amount of protection of breast tumor symptom crowd.Such protected working will need complicated automatic apparatus operating to finish detection process reliably.
The X ray of existing X-ray radiography method absorbs density resolution and is not enough to provide reliable malignant tumor early discovery.The probability that studies show that the breast tumor transfer that surpasses the 1cm size significantly increases.This size tumor seldom produces enough contrasts and can be found in mastogram.Can found contrast need the 2-3cm size in mastogram, producing.It seems that the calcium deposit that is used for the inference detection of traditional mastogram tumor also be associated with large-sized tumor.Because these factors, mastogram relative nullity in the detection of this condition.
The most mastogram devices that use in clinic and hospital today need the breast compressions technology, and it is extremely uncomfortable and be painful to the patient in a lot of cases.In addition, X ray constitutes ionizing radiation, gives as the mastogram technology of widespread usage and has injected further risk factor.
Ultrasound wave has been suggested as United States Patent (USP) 4075883, and it needs chest to be dipped into the scanning room of full of liquid.United States Patent (USP) 3973126 also needs chest to be dipped into the chamber of the full of liquid that uses the X-ray scanning technology.
Recently, the use of light and particularly do not invade in the health and the laser of reveal internal structure is studied.This technology is called as optical imagery.Optical imagery and spectroscopy are the key components of optical tomography.Past 10 years develop the forward position of optical tomography being pushed to clinical practice rapidly.The optical wavelength photon does not resemble the x-ray photon with straight line quick penetration tissue.This phenomenon causes that photon was dispersed in organization internal before being revealed in beyond the sample that is scanned.
Because it is collinear basically that x-ray photon is propagated, the relatively directly forward direction technology of changing based on radon has been designed to the computerized tomography image of generation by the algorithm that uses a computer.Some measurements are carried out around being scanned target by 360 °.These measurements are called as projection, are used for presentation data behind the scenes to cause the inside image representative that is scanned target.
In optical tomography, mathematical formulae and shadow casting technique have been designed to carry out some reconstruction function similar in appearance to the X ray tomography.In order to implement to rebuild accurately, must know the measured scanning target localization point of data thereon.
Check by the image reconstruction of the tissue of optical scanning, need to discern to be shown in in-house target type.In case target is identified and accurate localization is determined, just be activated based on effective treatment of luminous energy medicine.
Summary of the invention
An object of the present invention is to provide a kind of use biochemical marker so that pinpoint laser image forming apparatus of inner tumour cell and the method thereof organized that be scanned to be provided.
Another object of the present invention provides the laser image forming apparatus of a kind of use cryptoscope (fluorophore), thereby cryptoscope is bonded to and is scanned in-house tumor cell by collecting the radiation density sent by cryptoscope so that the accurate location of tumor cell to be provided when being encouraged by the laser beam of device.
Another purpose of the present invention provides a kind of method that is used for containing at the tissue that is scanned the image reconstruction collection data of tumor cell, a kind of detector array that is used for laser image forming apparatus, and a kind of device that is used for target imaging.
According to an aspect of the present invention, provide a kind of device that is used for target imaging, having comprised:
Be used for receiving therein the scanning room of the target that is scanned;
One places the laser beam sources in the described scanning room, the target that is scanned in order to bump;
In described chamber, be configured to a plurality of detectors around an arc of an opening, be placed with the target that will be scanned in the opening;
Each described detector comprises that one is matched with by after the laser beam activation, is sent the optical wavelength restriction light filter of radiating wavelength by the biochemical marker that adds to the tumor cell in the target;
Described a plurality of detector is configured to the track around described target; A sensor array is used to detect in the track that is configured to around described target, in each position of described laser beam, the rum point of described laser beam on the described target that is scanned, thereby obtains the circumference data of described target; And
A computer, it is programmed obtaining described circumference data and at the corresponding output valve of each detector of each position in the track of the described target image with the described target of reconstruct, and determines the shortest path length of described laser beam to described tumor cell from the image of described reconstruct.
In one embodiment, described light filter is a band pass filter.
In one embodiment, described light filter is a cut-off filter.These and other objects of the present invention become clear in by the following detailed description.
Description of drawings
Fig. 1 is the side front elevational schematic that comprises the scanning means of scanning room made in accordance with the present invention, shows that the patient is positioned on the supporting platform, and its chest hangs down in the scanning room that checks in order to optical tomography.
Fig. 2 is the floor map of Fig. 1 scanning room, shows the finite region of each detector points and the tree-like length of optics of passing through the laser beam of target.
Fig. 3 is the circuit block diagram from each detector data of collecting.
Fig. 4 is the sketch map of Fig. 2 scanning room.
Fig. 5 is the response curve of each detector data point of each angle position on the expression scanner rails.
Fig. 6 is the enlarged cross section figure that shows the detector parts of a light filter that places the photodetector front.
Biochemical label of Fig. 7 A demonstration is tied up in a malignant cell.
The tumor cell colony that Fig. 7 B is retrained by biochemical marker and show that biochemical label sends radiating sketch map after by laser pumping.
Fig. 8 shows cryptoscope excitation and the emission spectra that detector is seen.
Fig. 9 is to be cut off the emission spectra that light filter is revised similar in appearance to Fig. 8.
Figure 10 is similar in appearance to Fig. 8, the emission spectra of being revised by band pass filter.
Figure 11 A shows and to follow the luminous energy medicine to tie up biochemical label in malignant cell.
Figure 11 B is delivered the tumor cell colony of biochemical marker constraint of luminous energy medicine and the sketch map that shows the exciting beam of bump medicine.
Figure 12 is the floor map of Fig. 1 scanning room, shows the laser beam location to be provided to the minimum path length of knub position, and the luminous energy medicine that is transported by biochemical marker in its load.
Detailed Description Of The Invention
A scanning means 2 discloses in Fig. 1 as United States Patent (USP) 5692511 is described.A patient 4 is prostrate in the upper surface of device 2, and its chest 6 hangs down in the scanning room 8.Come the laser beam of self-excitation light source 10 can be connected in scanning room 8 with irradiation chest 6 with moving.
Each detector parts 12 comprises an opaque outer 24 that has open front 26 and rear end 28, wherein is equipped with detector 30.Thereby fiber optic cables (not shown) can be used to rear end 28 with pipe and is connected to and is positioned at detector 30 at a distance and easily detector is separated each other noise signal is minimized.The inner surface of shell 24 can be tubulose, circle, square or other cross sectional shape.Shell 24 is designed to limit the viewing area of its each detector 30, and each detector can only be seen its pocket that is scanned target like this.The viewing area of each detector parts 12 is by labelling 32 expressions.The pimple that is scanned on the target that each detector parts is seen is represented by labelling 34.
Each detector or pick off 30 are operatively coupled to its sampling and maintenance integrator 40 separately, as shown in Figure 3.Multiplexer 42 is used to the output of each integrator is connected to analog-digital converter 44.Digitized single detector or pick off response are stored in the computer 47 image reconstructions use of memorizer 46 in order to the back.Circuit is permitted the data of all detectors 30 of each angle position on the track that obtains scanning room 8 simultaneously.Sampling and to keep integrator 40 to be further described in the serial number that proposed on November 26th, 1997 be that it is merged reference at this in 08/979328 the application.
Circumference data each angle position on the track of scanning room 8 that is scanned target obtains.It is that it is merged reference at this in 08/965148 and 08/965149 the application that several method is disclosed in the serial number that proposed on November 6th, 1997.A kind of method is to use the sensor arrangement 49 that places with laser beam 16 homonymies, as shown in Figure 2.Laser beam 16 is scanned target by the orbit centre bump.Luminous point results from a little 18.On each distance from orbit centre, the particular components in the sensor arrangement 49 can exploring spot.When the holder of laser beam 16 and scanner about center ring when being scanned target, the output signal of sensor arrangement 49 will be directly related to the circumference that is scanned target.Obtain data by the target that is scanned of using one or more known diameter, the level of sensor signal can be calibrated about being scanned aimed dia.After the calibration, sensor signal can be decoded to draw the coordinate that is scanned the target circumference when being scanned target at scanner by electronics.
It is favourable obtaining the circumference data during the data collection of each section, so that target moves the error minimize that causes between slice position.Circumference data and corresponding detector data are used together to the reconstructed object image.The circumference data are made up of the distance from orbit centre on each angle position of track.
The circumference data of each angle position are collected simultaneously on the data of curve 48 representatives and the track, until the complete circumference of track process.Each scanner 8 around during the data that the obtain chromatography imaging technique by using a computer be used for rebuilding the image that is scanned target.The serial number that on November 28th, 1997 proposed is 08/979624 application, discloses a kind of image reconstruction method, and it is merged reference at this.
Each detector parts 12 has the spectral response of a light filter 50 with restriction detector 30 in limited viewing area.Light filter 50 can be band pass filter or cut-off filter.The purpose of light filter 50 will be by becoming clear in the following announcement.
Biochemical marker or label are easily in order to provide the high s/n ratio in the response curve 48 and the accurate location of malignant cell in the chest is provided.Biochemical label 51 is tied up the malignant cell 52 in normal populations 54, shown in Fig. 7 A.Biochemical label 51 has fluorescent characteristic when by homogeneous beam 16 irradiations radiation 55 is shown in Fig. 7 B.The wavelength ratio of fluorescent radiation from the wavelength of exciting light beam fully many, about 5-35nm, carry out fluorescent radiation with permission detector 30 and survey.Exciting light beam 16 is represented with curve 58 with curve 56 and fluorescent radiation, as shown in Figure 8.Light filter 50 further strengthens the ability of detector 30 only to respond those wavelength corresponding to the emission spectra 58 of fluorescent mixture.
With reference to Fig. 9, light filter 50 comprises a cut-off filter.The emission spectra 58 of fluorescent mixture or cryptoscope has been cut off the light filter correction, by zone 60 representatives, to limit the spectral region that detector 30 is seen.Cut-off filter has weakened significantly than by the short wavelength of boundary and further isolated detector 30 and exiting spectrum 56, allows emission wavelength to pass light filter simultaneously and arrives detector 30.
With reference to Figure 10, light filter 50 comprises the spectral region that a band pass filter is seen with restriction detector 30.Band pass filter is by cutting off than the short or long wavelength correction emission spectra 58 of the logical boundary of band, shown in the zone among Figure 10 62.
When fluorescent mixture was introduced into health, it can retrain malignant cell.In breast imaging, fluorescent mixture is introduced health and will be caused the chest malignant cell to be coupled with special tag.When chest during by the strong light beam irradiates of suitable wavelength, fluorescent mixture can send the light of its natural frequency.Be equipped with by or the scanner of band pass filter in 30 of detectors allow fluorescence spectrum excitation detector.Optics is rebuild algorithm demonstration is scanned fluorescence position in the chest border.Be equipped with and only see this spectrographic suitable light filter because have only fluorescent mixture to send narrow spectrographic light and detector, so obtain high s/n ratio easily and can accurately locate malignant cell in the chest.
Collagen protein is the fluorescence that a kind of 488nm of having absorbs (excitation) bandgap wavelength and 500+nm autofluorescence wavelength.Peridinin-Chlororophyll is disclosed in United States Patent (USP) 4876190, is that another kind has the biochemical marker that 440nm absorbs (excitation) bandgap wavelength and 660nm autofluorescence wavelength.
Some drugs is called luminous energy treatment (PDT) medicine, photoactivation that can chosen wavelength.What do is that the active region that limits the PDT medicine only is knub position.The breast imaging performance with the location of setting up suspicious region in the chest and in chest the performance of location fluorescence the basis of PDT treatment plan is provided.As seen with reference to Figure 11 A, tie up malignant cell 52 in normal populations 54 with the biochemical label 51 of luminous energy medicine 64.The selectivity characteristic of biochemical marker 51 has guaranteed that luminous energy medicine 64 is transported to tumor cell 52.Lasing light emitter 16 is adjusted to provides the special wavelength that activates the PDT medicine, shown in Figure 11 B.A kind of like this adjustable laser is well known in the prior art.By knowing the fluorescence position, and know knub position thus, thereby effective treatment is determined to be provided for to the knub position minimal path in aiming laser source 16.
Lutetium Texaphyrin PCI-0123 (Lu-Tex) is a sample of PDT medicine.It has 732nm absorption band wavelength, and 90% light absorption is in the 723-741nm wave-length coverage.It can be obtained by the Pharmacyclics company limited.Photofrin is another sample.It has the 632nm absorbing wavelength, and can be obtained by the QTL Photo Therapeutics company limited of Toronto.Also having a sample is long wavelength's soluble chloride photosensitizer, and luminous energy treatment and diagnosis as tumor are disclosed in United States Patent (USP) 5330741, have the 600-800nm absorbing wavelength.
With reference to Figure 12, the chest 6 that has a knub position 66 has been scanned instrument 8 scannings, because the correct location of tumor cell is provided in the fluorescence of the biochemical marker of tumor cell in addition.Light filter 50 is by labelling 68 representatives.Scanner subsequently by set again so that the shortest path length of laser beam 16 to knub position 64 to be provided.The wavelength of laser beam 16 is selected as activating the PDT medicine.
When breast tumor was surveyed as the main lime light of the present invention, those of ordinary skills can understand that it also can be applied to the other parts of health.
When the present invention is described by decision design, can do further correction, utilization and/or change according to rule of the present invention as can be known, and comprise such as thing suitable of the present invention known in the state of the art or that custom is carried out, and can use the thing of being illustrated basic feature, although not at the row of the disclosure, fall in the present invention or the appended claims restricted portion.
Claims (3)
1. device that is used for target imaging comprises:
A scanning room that is used for receiving therein the target that is scanned;
One places the laser beam sources in the described scanning room, the target that is scanned in order to bump;
In described chamber, be configured to a plurality of detectors around an arc of an opening, be placed with the target that will be scanned in the opening;
Each described detector comprises that one is matched with by after the laser beam activation, is sent the optical wavelength restriction light filter of radiating wavelength by the biochemical marker that adds to the tumor cell in the target;
Described a plurality of detector is configured to the track around described target;
A sensor array is used to detect in the track that is configured to around described target, in each position of described laser beam, the rum point of described laser beam on the described target that is scanned, thereby obtains all long datas of described target; And
A computer, it is programmed obtaining described all long datas and at the corresponding output valve of each detector of each position in the track of the described target image with the described target of reconstruct, and determines the shortest path length of described laser beam to described tumor cell from the image of described reconstruct.
2. device as claimed in claim 1, wherein said light filter are band pass filters.
3. device as claimed in claim 1, wherein said light filter are cut-off filter.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1999/004287 WO2000060323A1 (en) | 1997-01-17 | 1999-04-01 | Laser imaging apparatus using biomedical markers that bind to cancer cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1348542A CN1348542A (en) | 2002-05-08 |
| CN1325022C true CN1325022C (en) | 2007-07-11 |
Family
ID=38255140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB998166081A Expired - Lifetime CN1325022C (en) | 1999-04-01 | 1999-04-01 | Laser imaging apparatus using biomedical markes that bind to cancer cells |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1325022C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103654730B (en) * | 2013-12-19 | 2016-04-20 | 北京大学 | A kind of fluorescent molecules imaging system based on LED light source and formation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5205291A (en) * | 1988-11-08 | 1993-04-27 | Health Research, Inc. | In vivo fluorescence photometer |
| US5309907A (en) * | 1991-09-04 | 1994-05-10 | Siemens Aktiengesellschaft | Measuring arrangement for examining a subject with visible, NIR or IR light |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| CN1126945A (en) * | 1993-07-16 | 1996-07-17 | 无创伤诊断技术公司 | Examination of breast tissue using time-resolved spectroscopy |
| EP0806640A2 (en) * | 1996-04-09 | 1997-11-12 | Nkk Corporation | Apparatus for measuring temperature of molten metal |
| US5692511A (en) * | 1995-06-07 | 1997-12-02 | Grable; Richard J. | Diagnostic tomographic laser imaging apparatus |
| US5719399A (en) * | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
| WO1998023206A1 (en) * | 1996-11-29 | 1998-06-04 | Imaging Diagnostic Systems, Inc. | Detector array for use in a laser imaging apparatus |
| US5865754A (en) * | 1995-08-24 | 1999-02-02 | Purdue Research Foundation Office Of Technology Transfer | Fluorescence imaging system and method |
-
1999
- 1999-04-01 CN CNB998166081A patent/CN1325022C/en not_active Expired - Lifetime
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5205291A (en) * | 1988-11-08 | 1993-04-27 | Health Research, Inc. | In vivo fluorescence photometer |
| US5309907A (en) * | 1991-09-04 | 1994-05-10 | Siemens Aktiengesellschaft | Measuring arrangement for examining a subject with visible, NIR or IR light |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| CN1126945A (en) * | 1993-07-16 | 1996-07-17 | 无创伤诊断技术公司 | Examination of breast tissue using time-resolved spectroscopy |
| US5692511A (en) * | 1995-06-07 | 1997-12-02 | Grable; Richard J. | Diagnostic tomographic laser imaging apparatus |
| US5865754A (en) * | 1995-08-24 | 1999-02-02 | Purdue Research Foundation Office Of Technology Transfer | Fluorescence imaging system and method |
| US5719399A (en) * | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
| EP0806640A2 (en) * | 1996-04-09 | 1997-11-12 | Nkk Corporation | Apparatus for measuring temperature of molten metal |
| WO1998023206A1 (en) * | 1996-11-29 | 1998-06-04 | Imaging Diagnostic Systems, Inc. | Detector array for use in a laser imaging apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1348542A (en) | 2002-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6693287B2 (en) | Laser imaging apparatus using biomedical markers that bind to cancer cells | |
| US7394053B2 (en) | Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data | |
| JP5134977B2 (en) | Fluorescence-mediated molecular tomography | |
| EP0144409B1 (en) | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin in tumor-specific markers excited by long wavelength light | |
| US7668587B2 (en) | Optical imaging of induced signals in vivo under ambient light conditions | |
| US7750311B2 (en) | Positron emission detectors and configurations | |
| US7110808B2 (en) | Method of optimizing radiosurgery and radiotherapy with metalloporphyrins | |
| JP2003532474A (en) | Medical optical image scanner using simultaneous acquisition of multi-wavelength data for breast images | |
| JP6053770B2 (en) | Integrated microtomography and optical imaging system | |
| CN1787778A (en) | System and method for therapy and diagnosis comprising optical components for distribution of radiation | |
| JP2003232736A (en) | Optical image forming method and optical image forming apparatus | |
| WO2008049773A2 (en) | Triple-modality imaging system | |
| US6380540B1 (en) | Radiation imaging using simultaneous emission and transmission | |
| JPH0433460B2 (en) | ||
| US9456794B2 (en) | Molecular imaging using radioluminescent nanoparticles | |
| CN1325022C (en) | Laser imaging apparatus using biomedical markes that bind to cancer cells | |
| US7977619B2 (en) | Detector array for use in a laser imaging apparatus | |
| US6100520A (en) | Detector array for use in a laser imaging apparatus | |
| Celentano et al. | Preliminary tests of a prototype system for optical and radionuclide imaging in small animals | |
| CN111938685A (en) | A gamma-fluorescence dual-mode imaging device and imaging method | |
| RU2176475C1 (en) | Matrix-type photodiode device for setting fluorescence diagnosis and carrying out phototherapy of pathological areas | |
| Kovalev et al. | Clinical Experience of Luminescent Diagnostics of Precancerous Diseases and Cervical Cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070711 |