CN1322552A - Antioxidant compound formulation with beta-carrotene as main component and preparation process - Google Patents
Antioxidant compound formulation with beta-carrotene as main component and preparation process Download PDFInfo
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- CN1322552A CN1322552A CN 01112892 CN01112892A CN1322552A CN 1322552 A CN1322552 A CN 1322552A CN 01112892 CN01112892 CN 01112892 CN 01112892 A CN01112892 A CN 01112892A CN 1322552 A CN1322552 A CN 1322552A
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- carotene
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- taurine
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Abstract
The present invention relates to new health food. The formulation of the antioxidant formula includes beta-carrotene, Se, vitamin C, vitamin E, licorice extract powder, taurine and starch. During its preparation, licorice extract powder, selenium rich yeast, taurine, starch, microcapsulized vitamin C powder, vitamin E powder and beta-carrotene are successively added and mixed, ground dried at low temperature and packed. It may be prepared into capsule. Eating it regularly can strengthen body's immunological, antioxidant and antisenility functions.
Description
The present invention is a kind of antioxidation compound prescription and technology based on beta-carotene, relates to a kind of new bio health food, and production technology.
Medical research both at home and abroad shows that the morbidity of some chronic disease is closely related with nutrition and life style, and the existence of the harmful substances such as oxygen-derived free radicals of internal metabolism generation can damage normal structure and cell.The Recent study report: beta-carotene has the effect of prevention gastric cancer.To radiation, flue dust and singlet oxygen Wheat Protein, the mutagenic action of inhibition MNNG (MNNG) is arranged.Damage to DNA has repair.Simultaneously, the powerful antioxidation protection macrophage of beta-carotene is avoided oxygen free radical injury.Relevant human senility mechanism has multiple theory, wherein the oxygen-derived free radicals theory is the causes of senescence of relatively generally acknowledging, the generation development that had proved oxygen-derived free radicals (OFR) and Senile disease already is closely related, comprises the damage that the antioxidation nutrient of vitamin C, vitamin E and beta-carotene, selenium and other trace elements can alleviate the 26S Proteasome Structure and Function of OFR pair cell as antioxidant.Antioxidation nutrient selenium, vitamin E, vitamin C and beta-carotene can alleviate the lipid peroxidation injury of little bovine aortic endothelial cells, significantly reduce the generation of lipid peroxide, have antiatherogenic effect.Find that in the research of taurine this chemical compound Wheat Protein and can promote lipid metabolism can effectively prevent hypercholesterolemia and atherosclerosis to lipid metabolism influence.Studies show that selenium and vitamin E are for the inductive NH of ultra-oxygen anion free radical
3T
3Apoptosis has inhibitory action, and selenic effect is particularly outstanding, and selenium mainly plays antioxidation by the active center that constitutes some antioxidase.Vitamin E is positioned on the cell membrane, has the oxidized formation of the unsaturated fatty acid of prevention H
2O
2And the protection cell membrane is exempted from oxidative damage.Hang down selenium (Se), low vitamin e (V by HPLC and biochemical analysis, investigation
E) meals and replenish above-mentioned substance after, to the relation of rat heart muscle gland aromatic acid content and oxidative damage, found that low Se, low V
EThe myocardium AMP of group and glutathione peroxidase are active to be reduced, as unites increase Se/V
E, this variation will be enhanced.Therefore, Se and V
EShortage, obviously cause the rat heart muscle oxidative damage, replenish Se and (or) V
E, then increase oxidation resistance and ATP amount.So the health food that at present single or several antioxidation nutrients are formed on the market occurs, but the threpsology is combined with tcm theory, according to the prescription appearance as yet of Chinese diet structure and dietary habit compatibility screening various nutrients.In recent years, single and several antioxidation nutrient combined health-care foods occur on the market, and certain function of health care is also arranged, and still from the angle of Nutrition and Metabolism, replenish single nutrient and can cause the organism metabolism imbalance, and equilibrium is the key of adequate nutrition.
Goal of the invention is: bonded compound prescription of Chinese medicine and western medicine and preparation technology thereof that a kind of antioxidation nutrient of compound low dose is provided.
The present invention's prescription does not contain hormone, comprises following active ingredient: natural extract beta-carotene, selenium, VC, VE, Radix Glycyrrhizae extractum powder, taurine, starch.Wherein selenium is the yeast rich in selenium of biological extraction, and VC is micro encapsulation VC, has the Radix Glycyrrhizae extractum powder of stomach function regulating effect, and the taurine of antioxidation, trophic nerve cell is arranged.
Each component dosage range of the present invention: (by weight percentage)
Beta-carotene 0.1-1
Selenium 0.001-0.0001
V
C 1-10
V
E 0.5-2
Radix Glycyrrhizae extractum powder 10-50
Taurine 1-10
Its surplus of starch
Preparing process based on the antioxidation compound prescription of bata-carotene is: the first step, preparation Radix Glycyrrhizae extractum powder; In second step, add yeast rich in selenium, taurine, starch, mix homogeneously; In the 3rd step, add micro encapsulation VC, VE powder, beta-carotene mix homogeneously; In the 4th step, grind; The 5th step, cold drying; Packing.Can be made into capsule, as every capsules 250mg, but every day taking dose 4-6 grain.
So replenishing curative effect from the nutrient of the compound low dose of curative effect can be better, as vitamin C the effect of saving vitamin E be arranged, and they are united utilization synergism are arranged; In addition, this prescription combines threpsology's theory with Chinese medical theory, be aided with the Chinese medicine Radix Glycyrrhizae extractum powder, the medicine that Radix Glycyrrhizae is used together for the food medicine, property is sweet, the stomach function regulating Detoxication is arranged, experimentation has the effect that suppresses peptic ulcer, suppresses helicobacter pylori, so Chinese medicine combines with the antioxidation nutrient, makes this product outside having higher anti-oxidation function (SOD activity improving, the lipid peroxide that reduces) effect, person's energy stomach is comfortable also to make clothes, and acceptability is better.
So the characteristics of this compound recipe are that prescription has the effect of the antioxidative synergism and the combination of Chinese and Western medicine, to improve user's acceptability, safeguard the human body cell normal function, prompting has delaying senility function.
The present invention is directed to the present situation that human body diseases characteristics and daily meals antioxidation nutrient lack, set about, according to the theory of oxygen-derived free radicals and health and disease, with single antioxidation nutrient: beta-carotene, V from safeguarding the human body cell normal function
C, V
E, compatibility mutually such as taurine, make them can play synergism aspect the oxygen-derived free radicals removing, can remove multiple oxygen-derived free radicals.
Superiority of the present invention is: do not contain hormone, and each active ingredient action compensating, nontoxic, have no side effect, can take for a long time, absorb taking convenience easily.In prescription, contained selenium is organic selenium, and favourable body absorbs; Vitamin C microcapsuleization, its anti-oxidation function of easier protection, and anti-storage.Compared with prior art have advantage or good effect is as follows: 1, this product through the Shanghai City health detect identify, the result shows old rats (15 monthly age) after product nourishing capsule powder of the present invention was fed in 30 days, and lipid peroxide content significantly reduces (P＜0.05).SOD vigor obviously raise (P＞0.05).Prompting has function in delaying senility.2, The acute toxicity tests shows, sample to the male and female mice lavage, is observed a week with the dosage of 10g/Kg, and not seeing has the acute poisoning symptom and the phenomena of mortality, i.e. LD50＞1 μ g/Kg.The micronucleus test result is shown as feminine gender, and the sperm malformation test result is shown as feminine gender, so that the present invention fills a prescription is nontoxic, have no side effect, can take for a long time.3, the present invention compares with existing like product on the market, and multiple compound anti-oxidation nutrient compatibility uses, and plays synergism.In addition, threpsology's theory is combined with Chinese medical theory, from the angle of balanced diet, in conjunction with the deficiency on compatriots' the diet structure, replenish the antioxidation nutrient of appropriate low dosage, make health-care effect better, acceptability is stronger.4, the compound anti-oxidation capsule is composited by the Chinese medicine of antioxidant vitamins, trace element, antioxidation aminoacid and stomach function regulating anti-helicobacter pylori, and it is more reasonable to fill a prescription.5, use antioxidative aminoacid taurine, not only strengthened antioxidation, and taurine also has trophic nerve, cardiac muscle and amphiblestroid effect, and the assosting effect that resisting fatigue is arranged, sleep peacefully.6, use the acceptable height of Chinese medicine (Radix Glycyrrhizae) stomach function regulating that inhibition helicobacter pylori and peptic ulcer are arranged.7, the combination of Chinese and Western medicine has the advantage complementary action.
Embodiment: with the 100g formulation material is example:
Maximum intermediate quantity minimum
Beta-carotene 1000mg 400mg 100mg
Selenium 10mg 5mg 1mg
V
C 10g 5g 1g
V
E 2g 1g 0.5g
Radix Glycyrrhizae extractum powder 50g 50g 10g
Taurine 10g 10g 1g
Starch 26.99g 33.595g 87.399g
The preparing process of above-mentioned antioxidation compound prescription based on beta-carotene is: the first step, preparation Radix Glycyrrhizae extractum powder; In second step, add yeast rich in selenium, taurine, starch, mix homogeneously; In the 3rd step, add micro encapsulation V
C, V
EPowder, beta-carotene mix homogeneously; In the 4th step, grind; The 5th step, cold drying; Packing.Can be made into capsule, conveniently take.
In above-mentioned example formulations, maximum and minimum all have clinical efficacy preferably, shown than significant antioxidant role, make SOD among the patients serum, LPO value that significant change be arranged, the skin brown macules disappears, the myocardial cell oxidation resistance strengthens, and can effectively prevent and treats some and the too much relevant chronic disease of oxygen-derived free radicals, takes energy enhancing human body immunity function and anti-oxidation function for a long time, improve Abwehrkraft des Koepers, prevent and treat some chronic disease.Confirm that through Ministry of Public Health this prescription series can effectively improve superoxide dismutase and activity of glutathione peroxidase, reduce lipid peroxide content, remove the murder by poisoning of harmful substances such as oxygen-derived free radicals, tool antioxidation and deferring senility.The present invention develops in the experience that Chinese medicine is used for preventing precancerous lesion of stomach cancer blocking-up research and and the actual control of clinical nutrition outpatient service teaching and research in conjunction with nutrition.
Claims (3)
1, the antioxidation compound prescription based on bata-carotene comprises bata-carotene, it is characterized in that: also comprise selenium, VC, VE, Radix Glycyrrhizae extractum powder, taurine, starch.
2, the antioxidation compound prescription based on 3 carotene according to claim 1 is characterized in that: by weight percentage
Beta-carotene 0.1-1
Selenium 0.001-0.0001
VC 1-10
VE 0.5-2
Radix Glycyrrhizae extractum powder 10-50
Taurine 1-10
Its surplus of starch
3, the preparing process based on the antioxidation compound prescription of bata-carotene is characterized in that: the first step, preparation Radix Glycyrrhizae extractum powder; In second step, add yeast rich in selenium, taurine, starch, mix homogeneously; In the 3rd step, add micro encapsulation VC, VE powder, 3-carotene mix homogeneously; In the 4th step, grind; The 5th step, cold drying; Packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01112892 CN1322552A (en) | 2001-05-16 | 2001-05-16 | Antioxidant compound formulation with beta-carrotene as main component and preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01112892 CN1322552A (en) | 2001-05-16 | 2001-05-16 | Antioxidant compound formulation with beta-carrotene as main component and preparation process |
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| Publication Number | Publication Date |
|---|---|
| CN1322552A true CN1322552A (en) | 2001-11-21 |
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ID=4659638
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|---|---|---|---|
| CN 01112892 Pending CN1322552A (en) | 2001-05-16 | 2001-05-16 | Antioxidant compound formulation with beta-carrotene as main component and preparation process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841128A1 (en) * | 2002-06-21 | 2003-12-26 | Oreal | Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss |
| WO2004000293A3 (en) * | 2002-06-21 | 2004-05-13 | Oreal | Use of taurine or derivatives thereof for the treatment of alopecia |
| CN100423652C (en) * | 2003-12-03 | 2008-10-08 | 广州优宝工业有限公司 | Natural beta-carotene microcapsule and preparation method thereof |
| CN102308915A (en) * | 2011-07-26 | 2012-01-11 | 上海交通大学 | Anti-oxidant composition for improving animal immune function and preparation method thereof |
| CN113041339A (en) * | 2021-03-23 | 2021-06-29 | 南通大学 | Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage |
| CN116616448A (en) * | 2023-05-08 | 2023-08-22 | 石药集团中诺药业（泰州）有限公司 | Vitamin C tablet containing organic selenium and production process thereof |
-
2001
- 2001-05-16 CN CN 01112892 patent/CN1322552A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841128A1 (en) * | 2002-06-21 | 2003-12-26 | Oreal | Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss |
| WO2004000293A3 (en) * | 2002-06-21 | 2004-05-13 | Oreal | Use of taurine or derivatives thereof for the treatment of alopecia |
| US9138408B2 (en) | 2002-06-21 | 2015-09-22 | L'oreal | Use of taurine for treating alopecia |
| CN100423652C (en) * | 2003-12-03 | 2008-10-08 | 广州优宝工业有限公司 | Natural beta-carotene microcapsule and preparation method thereof |
| CN102308915A (en) * | 2011-07-26 | 2012-01-11 | 上海交通大学 | Anti-oxidant composition for improving animal immune function and preparation method thereof |
| CN113041339A (en) * | 2021-03-23 | 2021-06-29 | 南通大学 | Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage |
| CN116616448A (en) * | 2023-05-08 | 2023-08-22 | 石药集团中诺药业（泰州）有限公司 | Vitamin C tablet containing organic selenium and production process thereof |
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