CN1303698A - Bitter gourd sugar-reducing capsule and its preparation process - Google Patents
Bitter gourd sugar-reducing capsule and its preparation process Download PDFInfo
- Publication number
- CN1303698A CN1303698A CN 99115925 CN99115925A CN1303698A CN 1303698 A CN1303698 A CN 1303698A CN 99115925 CN99115925 CN 99115925 CN 99115925 A CN99115925 A CN 99115925A CN 1303698 A CN1303698 A CN 1303698A
- Authority
- CN
- China
- Prior art keywords
- fructus momordicae
- momordicae charantiae
- bitter gourd
- total saponin
- bitter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000009811 Momordica charantia Nutrition 0.000 title claims abstract description 35
- 235000008322 Trichosanthes cucumerina Nutrition 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002775 capsule Substances 0.000 title claims abstract description 9
- 244000302512 Momordica charantia Species 0.000 title claims description 27
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 19
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 19
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 19
- 229930182490 saponin Natural products 0.000 claims abstract description 19
- 150000007949 saponins Chemical class 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 18
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 230000008014 freezing Effects 0.000 claims abstract description 6
- 238000007710 freezing Methods 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000002893 slag Substances 0.000 claims description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000005516 engineering process Methods 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 4
- 238000005352 clarification Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 3
- 244000078912 Trichosanthes cucumerina Species 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 241000218984 Momordica Species 0.000 description 1
- 235000009812 Momordica cochinchinensis Nutrition 0.000 description 1
- 235000018365 Momordica dioica Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention use fresh bitter gourd as raw material, and adopts the processes of freezing, icing pulp and press-filtering to respectively prepare bitter gourd residue powder, bitter gourd protein powder and bitter gourd total saponin, then mixing the bitter gourd residue powder, the bitter gourd portein powder and the bitter gourd total saponin according to the mixing ratio of 95.4:0.6:4 uniformly, and capsulizing so as to obtain the invented product bitter gourd sugar-reducing capsule as auxiliary preparation for curing diabetes with obvious therapeutic effect without toxic side-effect.
Description
The present invention relates to a kind of bitter gourd sugar-reducing capsule and preparation technology thereof.
Fructus Momordicae charantiae is a kind of plant of Cucurbitaceae Momordica, be a kind of vegetable that China various places masses like food, abnormal smells from the patient hardship, cold, nontoxic, have and remove pathogenic heat, separate tired, the effect such as make eye bright, QI invigorating is analgesic that clears away heart-fire, it also is a kind of important prescription raw material as the treatment diabetes medicament.Products such as existing balsam pear buccal lozenge, owing to added school flavor agent, filler, pigment etc., production technology is comparatively simple, can not effectively biological active substanceies such as having blood sugar lowering, blood fat reducing in the Fructus Momordicae charantiae be extracted, and has reduced the medicinal effects of Fructus Momordicae charantiae widely.
The object of the present invention is to provide a kind of is single raw material with Fructus Momordicae charantiae, does not add the bitter gourd sugar-reducing capsule and the preparation technology thereof of any additives, craft science.
The present invention is made up of the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag, and its weight ratio is the total Saponin of Fructus Momordicae charantiae: bitter melon protein powder: Fructus Momordicae charantiae ground-slag=4: 0.6: 95.4.Its preparation technology is: at first with fresh medium sophisticated Fructus Momordicae charantiae, remove the seed flesh after, through clean, freezing, store standby; Secondly below 15 ℃ the Fructus Momordicae charantiae pulp being made in freezing Fructus Momordicae charantiae pulverizing, obtain filtering residue and filtrate, filtering residue drying → pulverizing → mistake 100 mesh sieves are made the Fructus Momordicae charantiae ground-slag through filter pressing; The 3rd, filtrate is being placed clarification in 12 hours below 15 ℃, after refiltering, filtrate is with PH3.0,70% acidic ethanol, stir below 15 ℃ and extracted 3 hours, static 12 hours after-filtration, obtaining precipitate is bitter melon protein and filtrate, bitter melon protein is crossed 100 mesh sieves and is made the bitter melon protein powder after cold drying; The 4th, filtrate is behind 60 ℃ of vacuum concentration, ether defatting → 50 ℃ the vacuum concentration that adds 2 times of volumes of the water dissolution of 2 times of volumes → add reclaims ether, reclaim ethanol through 60 ℃ of vacuum concentration again and make the total Saponin of thick Fructus Momordicae charantiae, through anhydrous propanone in precipitation below 4 ℃, washing for several times, vacuum concentration below 30 ℃ is made the total Saponin of Fructus Momordicae charantiae; Press the total Saponin of Fructus Momordicae charantiae at last: the bitter melon protein powder: the weight ratio of Fructus Momordicae charantiae ground-slag=4: 0.6: 95.4 with the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag mixing, incapsulates and gets final product.
The invention has the advantages that raw material sources are wide, technology is simple, taking convenience, and low price, without any side effects, evident in efficacy as the auxiliary agent of treatment diabetes, be beneficial to popularization.
With preferred example the present invention is described in further details below:
The present invention is made up of the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag, and its weight ratio is the total Saponin of Fructus Momordicae charantiae: bitter melon protein powder: Fructus Momordicae charantiae ground-slag=4: 0.6: 95.4.Its preparation technology is: at first with fresh medium sophisticated Fructus Momordicae charantiae, remove the seed flesh after, through clean, freezing, store standby; Secondly below 15 ℃ the Fructus Momordicae charantiae pulp being made in freezing Fructus Momordicae charantiae pulverizing, obtain filtering residue and filtrate, filtering residue drying → pulverizing → mistake 100 mesh sieves are made the Fructus Momordicae charantiae ground-slag through filter pressing; The 3rd, filtrate is being placed clarification in 12 hours below 15 ℃, after refiltering, filtrate is with PH3.0,70% acidic ethanol, stir below 15 ℃ and extracted 3 hours, static 12 hours after-filtration, obtaining precipitate is bitter melon protein and filtrate, bitter melon protein is crossed 100 mesh sieves and is made the bitter melon protein powder after cold drying; The 4th, filtrate is behind 60 ℃ of vacuum concentration, ether defatting → 50 ℃ the vacuum concentration that adds 2 times of volumes of the water dissolution of 2 times of volumes → add reclaims ether, reclaim ethanol through 60 ℃ of vacuum concentration again and make the total Saponin of thick Fructus Momordicae charantiae, through anhydrous propanone in precipitation below 4 ℃, washing for several times, vacuum concentration below 30 ℃ is made the total Saponin of Fructus Momordicae charantiae; Press the total Saponin of Fructus Momordicae charantiae at last: the bitter melon protein powder: the weight ratio of Fructus Momordicae charantiae ground-slag=4: 0.6: 95.4 with the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag mixing, incapsulates and gets final product.
Claims (4)
1. bitter gourd sugar-reducing capsule is characterized in that it is made up of the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag, and its weight ratio is: the total Saponin of Fructus Momordicae charantiae: bitter melon protein powder: Fructus Momordicae charantiae ground-slag=4: 0.6: 95.4.
2. the preparation technology of a bitter gourd sugar-reducing capsule, it is characterized in that it be with fresh Fructus Momordicae charantiae freezing through cleaning → low temperature slurrying → filter pressing after, with filtering residue drying pulverizing → mistake 100 mesh sieves, make the Fructus Momordicae charantiae ground-slag; Filtrate clarification refilters, after acidic ethanol stirs extraction → filtration with precipitate through cold drying → mistake 100 mesh sieves, make the bitter melon protein powder; Filtrate reclaims ether → 60 a ℃ vacuum concentration through 2 times of water dissolutioies of 60 ℃ of vacuum concentration → add → add, 2 times of ether defatting → 50 ℃ vacuum concentration and reclaims ethanol and make the total Saponin of thick Fructus Momordicae charantiae, through anhydrous propanone in washing of precipitate below 4 ℃ for several times, vacuum concentration below 30 ℃ is made the total Saponin of Fructus Momordicae charantiae again; At last the total Saponin of Fructus Momordicae charantiae, bitter melon protein powder and Fructus Momordicae charantiae ground-slag are got final product through mixing → incapsulate by 10: 2: 88 weight ratios.
3. the preparation technology of a kind of bitter gourd sugar-reducing capsule as claimed in claim 2 is characterized in that described low temperature slurrying, and temperature is below 15 ℃.
4. the preparation technology of a kind of bitter gourd sugar-reducing capsule as claimed in claim 2 is characterized in that described acidic ethanol stirs that to extract be to extract static 12 hours with PH3.0,70% acidic ethanol 3 hours stirring below 15 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99115925 CN1303698A (en) | 1999-12-02 | 1999-12-02 | Bitter gourd sugar-reducing capsule and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99115925 CN1303698A (en) | 1999-12-02 | 1999-12-02 | Bitter gourd sugar-reducing capsule and its preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1303698A true CN1303698A (en) | 2001-07-18 |
Family
ID=5278813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99115925 Pending CN1303698A (en) | 1999-12-02 | 1999-12-02 | Bitter gourd sugar-reducing capsule and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1303698A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2867076A1 (en) * | 2004-03-03 | 2005-09-09 | Ryusendo Co Ltd | FOOD SUPPLEMENTS AND PHARMACEUTICAL PRODUCTS |
| US20110097415A1 (en) * | 2009-10-26 | 2011-04-28 | Yaguang Liu | Sustained release of pharmaceutical composition containing a safe botanic drug for the treating and preventing of diabetes |
| US9034400B2 (en) | 2011-01-28 | 2015-05-19 | Piramal Enterprises Limited | Process for preparation of a herbal extract |
| CN108014160A (en) * | 2016-11-02 | 2018-05-11 | 李基镐 | The mixed-powder and its capsule and manufacture method of campanulaceae and balsam pear |
-
1999
- 1999-12-02 CN CN 99115925 patent/CN1303698A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2867076A1 (en) * | 2004-03-03 | 2005-09-09 | Ryusendo Co Ltd | FOOD SUPPLEMENTS AND PHARMACEUTICAL PRODUCTS |
| US20110097415A1 (en) * | 2009-10-26 | 2011-04-28 | Yaguang Liu | Sustained release of pharmaceutical composition containing a safe botanic drug for the treating and preventing of diabetes |
| US8114444B2 (en) * | 2009-10-26 | 2012-02-14 | Yaguang Liu | Pharmaceutical composition containing Momordica charantia L. extracts for lowering blood glucose |
| US9034400B2 (en) | 2011-01-28 | 2015-05-19 | Piramal Enterprises Limited | Process for preparation of a herbal extract |
| CN108014160A (en) * | 2016-11-02 | 2018-05-11 | 李基镐 | The mixed-powder and its capsule and manufacture method of campanulaceae and balsam pear |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |