CN1288050A - Multi-functional and high efficiency composite for washing, sterilizing and used as medicine and its prescription technology - Google Patents

Abstract

A multifunctional efficient composition for cleaning, disinfecting and medical purpose contains a buitl-up matter including acidic, neutral and alkaline peroxides to generate stable and effective disinfecting effect, a benzoic acid derivative with excellent disinfecting effect, at least 3 emulsifiers or activators for forming stable releasing system and generating cleaning and anticorrosion effect, phosphate buffer liquid for stabilizing emulsion system, and a group of organic substances for protecting skin and playing medicine role.

Description

A kind of multifunctional efficient is washed, is disappeared, medicinal compositions and prescription technology

The present invention relates to wash, sterilization, medicinal, derust, the composition of rust inhibition, the washing and the rot-resistant effect of the washing of the excellent safety of said composition, sterilization, treatment and metal oil rust are applicable to that the washing of family, hospital equipment, foodstuffs industry plant and instrument and sterilization also are simultaneously the decontaminants that people's skin and environment is not had harm; Tetter to the people has curative effect preferably simultaneously, aspect the processing of oil rust application is preferably being arranged also at metal.

Most popular in the world at present cleaning and disinfecting articles for use are chlorine-containing compound, quaternary ammonium salts and hydroperoxide kind, and it is higher to have a sterilisation effect, the characteristics that bactericidal range is wider.

But chlorine-containing compound such as clorox, chlorinated isocyanuric acids, maximum defective is strong and stimulating and corrodibility (to people's skin and metal), the smell is awful, less stable.Though Chinese patent CN86104098A can allow chlorinated isocyanuric acid under acidic conditions, and is more stable, but still keep away unavoidable pungency and smell.

Quaternary amine has significant fungicidal activity, but quaternary ammonium salt is relatively large to the toxic of people's skin, although Chinese patent CN1203513A claims that this compounds is non-irritating relatively, often find that according to compound concentrations the thing that in most of the cases should not take place has taken place.For addressing toxic side effect and pollution problem, Chinese patent CN1196180A, German Patent 2904217 and United States Patent (USP) 5916568 adopt hydrogen peroxide respectively, make the sterilizing agent of solvent with alcohol, it is good to have sterilisation effect, pungency is low but stable and washing effect is relatively poor, composite function singleness, and applicable surface is in fact narrower.

For addressing this problem, design a kind of novel method and component, make said composition have multifunctional efficient, stability, the decontamination solution that security is more excellent.

An object of the present invention is to provide novel multiple peroxide and cross the quantitative combination formula of thing, producing widely applicable, pH value is all having efficient, stable sterilization effect at 2-13, and said composition is extremely low to the pungency that people's skin is produced.

One object of the present invention provides a kind of composition that contains benzoic acid derivative, can slowly discharge Whitfield's ointment and acetate in solution, two kinds of organic bactericides, and and superoxide interosculate, produce more excellent sterilization effect.

An object of the present invention is to provide a kind of safe, compound and with the composition of the better emulsifying agents of sterilant affinity such as superoxide, benzoic acid derivative, make said composition have more stable sterilization effect and washability efficiently, environmentally safe.

Another object of the present invention provides a kind of medicinal cleaning composition, contains efficient inorganic, organic bactericide, fungistat and skin protein conditioning in the said composition, and affine medicine is effectively treated moistening of tetter and normal skin.

One object of the present invention is to provide to have the buffer solution system composition of a kind of phosphate buffered to constituting, the pH value of said composition is not subjected to the influence of extraneous factor to a certain extent, plays a part sterilant and the stable chelating alkalimetal ions that reach of emulsifier system such as stable peroxide thing.

Another object of the present invention is that a kind of agricultural chemicals emulsion residual on fruit, the vegetables or composition of crystal grain of more effectively dissolving is provided, and the emulsifying agent in the said composition is no matter on structure and should have the effect of this reality in nature.

Another object of the present invention provides and contains moistening to metal and promoting agent filming function in a kind of composition said composition with industrial use value, with the pH value of preceding regulator solution a little, just become cleaning and sterilizing Beer Bottle, beverage bottle or metal oil rust washing composition.

Hydrogen peroxide is a kind of oxygenant commonly used, can be dissolved at an easy rate in the water, in alcohol, ether, the ester, if there are factors such as metal ion and pH value fluctuation then unstable in the solvent, easily divides liberation oxygen.Can form title complex (superoxide) with organic and inorganic thing according to hydrogen peroxide, in the molecule, bonding is to form owing to the hydrogen between electron rich functional group in the complex compounds and the hydrogen peroxide molecule is strong, and the superoxide of formation has improved stabilization of peroxide and purposes to a great extent.The present invention utilizes control superoxide stable outstanding effect of emitting active oxygen and optimizing with other sterilant in water:

Optimization decontamination composition of the present invention contains:

The specified proportion preparation of (I) three kinds of superoxide:

(a) double salt of persulfuric acid hydrogen salt, raw material is easy to get, and can make by oneself easily, and potassium hydrogen persulfate wherein is best, and its feature is in pH value is the 2-4 scope, and is very stable, is a kind of acid superoxide, and sterilization is more effective in sour environment.

(b) urea peroxide (urea): it water-soluble splendid, good stability changes that PH is between the 6-7 behind the molten water, near the pH value of human body, and has the double properties that urea and peroxide are stopped hydrogen, produces conveniently, be a kind of near neutral environment the ideal sterilant.It has following advantage (data proves).

1. in water, can play the effect that increases tensio-active agent solubility;

2. it with phenylformic acid and derivative thereof, the high-carbon ester is mutually composite can strengthen antibacterial, antibacterial effect.

3. itself and and the composite tetter such as keratinization that can treat effectively with skin care of other medicines.

(C) Sodium peroxoborate: it is a kind ofly at pH value the superoxide of better fungicidal activity to be arranged between 8-13, and can produce a spot of boric acid under acidic conditions also can sterilization.

Three kinds of compound proportions of crossing the oxysome thing are 1%-12%: 2%-15%: the 1%-12% optimum proportion should be: 2%-8%: 8%-12%: 2%-9%, this compounded technology can guarantee that composition is all to have the ideal sterilization effect between the 2-13 at pH value, becomes the decontaminant that can both effectively be used in acidity, neutrality and alkaline environment.See Table (1)

Decontamination composition of the present invention contains

(II) is safe, emulsifying agent that germ resistance is high and tensio-active agent, according to the superoxide dissolution characteristics of (comprising hydrogen peroxide), my design alternative contains the promoting agent of ester group and ether, and this helps, and sterilant is disperseed, emulsification and keep relatively independent separately stable properties.This composition comprises two kinds of nonionic emulsifier at least.

(III) this composition includes a kind of organism sterilant:

It can stablize 2-acetoxy-benzoic acid 0.1-15% in emulsion and discharge Whitfield's ointment and acetate, the three all is better sterilant, and it is additional mutually with the superoxide in (I), has played better sterilization effect, it has significant curative effect to the treatment ringworm of the foot in addition.Best dose is 0.1-3%.

(IV) this composition contains:

More comprehensive skin moisturizing agent glycerine 1-10%, protolysate 1-5% lanolin 1-5%, borneol (borneol), refrigerant, can itching-relieving action, these materials of 0.1-3% are nursing skin very significantly, and skin skin county in Shandong Province ripper is had curative effect more than 95%.See Table (2).

(V) this composition contains:

Alkali metal pyrophosphate salts, potassium, sodium all can, account for 0.5-5%, it and phosphoric acid dioxy potassium and Sodium phosphate dibasic are 1 by mass ratio: 2-1: 3, between the solution pH value 5-8.

(VI) this composition comprises a kind of like this purposes:

Make the solution pH value in the 2-5 scope, can eliminate oil rust on the metal effectively by adding sulfuric acid or phosphoric acid, add the alkali pH value and can be used as Beer Bottle and beverage bottle clean-out system at 8-13, respond well, see Table (4) by above compounded technology, can be used as the purposes of enterprise's decontaminations such as family, hospital, foodstuffs industry.(see Table 5 and table 6).

Embodiment 1: a kind of multifunctional efficient decontamination pharmaceutical composition (prescription).

Potassium hydrogen persulfate 2%-8%

Carbamide peroxide 3%-12%

Sodium peroxoborate 2%-9%

Sorbitol anhydride oleate polyethers 8%-15%

Sorbitol anhydride oleate 8%-18%

C ₈-C ₁₄Alkyl two acyl gastral cavity 2%-3%

C ₈-C ₁₆Alkyl betaine 8%-15%

2-acetoxy-benzoic acid 0.1%-3%

Glycerol 1%-5%

Protolysate 1%-5%

Lanolin 1%-5%

Borneol 0.1%-3%

Trisodium phosphate 0.5%-5%

Ethylenediamine tetraacetic acid (EDTA) 0.1-3%

Phosphate buffered saline buffer is adjusted between the composition PH=5-8

Embodiment 2: comprehensive test data contrast tables (1) such as sterilization

Attached:

1, antibacterial and serology detects judgement criteria: killing rate 99% or more efficient (all killing) be outstanding more than 96%; Be good more than 90%; Be good more than 85%.

2, the different concns of sample is adopted in antirust ability test, is placed in the beaker, puts into 10 little iron nails respectively, soaks 24 hours, takes out, cleans, drying is back, visual and by microscopic examination, the corrosion degree of metallic surface.

Embodiment 3, and experiment (a) is to people's flesh dermatophytosis and nursing conditioning pilot survey, and the specific aim granting is unit with the family, uses voluntarily, regains 18 people's questionnaires, carries out statistical induction:

Table (2)

Experiment (b)

Test the mensuration of this combination liquid stoste to the antibacterial coefficient of fungi:

Employing is coefficient with the PHENOL 99.8 MIN ((CARBOLIC ACID)), and antibacterial index calculates with cm, measurement result:

Table (3)

To the concrete curative effect of implementing of dermatosis patient and consistent, confirm that combination liquid of the present invention has the good curing effect really to human skin tinea disease by composition of the present invention with the mycostatic practical measurement result of medicine.

Embodiment 4, and the washing of glass slide standard greasy dirt is measured:

The little microscope slide of clean microscope is adopted in test, and every group each 10, in the standard greasy dirt, soaked 3-5 minute, press from both sides out, put into washings and soaked 5 minutes, use tweezers then in washings agitator treating 2-3 minute, with the aquae destillata flushing, visual and microscopically observation.

Table (4)

The accurate greasy dirt preparation of affix:

Viscotrol C: white oil: lanolin=1: 1: 1 (weight ratio) adds mixing oil 5g, fourth of the twelve Earthly Branches phosphatidase 11 0g, and carbon black liquid 500ml, 50% ethanol 50ml is diluted to 1500ml.

Embodiment 5: the present composition is removed the test of metal oil rust:

The present composition makes its PH between 2-5 by adding sulfuric acid or phosphoric acid, and the band brown oil of respectively getting 5 equals in quality little iron nail that becomes rusty is placed in the beaker, puts into test solution, and take out the heat back a little, and visual and microscopically is observed:

Table (5)

The test solution kind	Consumption	The used time	Temperature of reaction	Effect assessment
The present composition	15％	The 5-10 branch	20-40℃	The Ex-all of brown oil rust, the metallic surface does not have corrosion
Chlorine-containing compound detoxicating liquid	15％	The 5-10 branch		Sump oil removes unclean, and rust is removed, and metal has the erosion line
A kind of liquid detergent	15％	The 5-10 branch		Can remove the oil rust, but metallic corrosion there is the microetch line

Test demonstrates the oil rust that component of the present invention can be eliminated metal effectively, and can corrosive nature not arranged to the metallic surface.

Embodiment 6: component of the present invention is as cleaning the Beer Bottle test:

This component adds 5N NaoH liquid, transfers pH value about 12-13, and 20 clean Beer Bottle test white vase debris and pH values thereof are got in the operation that bottle is spilt in the washing of simulation factory.Concrete grammar: every clean bottle is fallen to erect 10 seconds kinds measure its drip situation again, wherein half drip refers to flow out a circle water in the bottleneck contact palm of the hand, and PH measures and measures with acidometer.

Table (6)

Debris＜3 droplet wherein, pH value＜7.5 are promptly qualified.

Embodiment 7, the safe performance indexes contrast:

The emulsifying agent that this composition is selected, auxiliary agent, promptly safe to the washing composition remarkable advantages of other similar class.

As main promoting agent, Sorbic Acid sugar acid anhydride oleic acid ester polyethers is the foodstuff additive LP50＞60ml/kg that uses always, and everyone oral every day of 60g meter of Sorbic Acid sugar acid anhydride acid esters 28 days have no effect, and pungency is extremely low.Trisodium phosphate and sodium phosphate etc. all are foodstuff additive or medical auxiliary agent, and biological degradation does not thoroughly have harm.Say on 26S Proteasome Structure and Function that in addition the nonionic emulsifying agent of this composition also is effective to agricultural chemicals product body and the newborn mark proof of removing on the fruits and vegetables.Therefore can say that this composition is safe to human body and environment, be a kind of promising free of contamination decontamination solution.

Promoting agent is as emulsifying agent:

(a) sorbitol anhydride oleate polyethers 5-20%

(b) sorbitol anhydride oleate 5-25%

(c) C ₈-C ₁₄Alkyl oxalamide 1-5%

This compound has good emulsifying, wetting and preservative activity.

(d) C ₈-C ₁₆Alkyl betaine

Has good wetting and skin condition function.

The best proportionings of four kinds of promoting agents are: the almost non-toxic side effect of 8%-15%: 8%-18%: 2%-3%: 8-15%, have in addition in foodstuffs industry additive be extensive use of, be to use safety environment not to be had the promoting agent of harm.

Claims (8)

1, a kind of multifunctional efficient decontamination composition is characterized in that containing potassium hydrogen persulfate double salt, urea peroxide (urea), and Sodium peroxoborate is pressed 1%-12%: 2%-15%: the mixed system of 1%-12%, its sterilizing ability is in the highly effective proportioning of pH value 2-13;

2, multi-functional decontamination composition as claimed in claim 1, it is characterized in that optimizing the proportioning potassium hydrogen persulfate double salt that uses: urea peroxide: Sodium peroxoborate is the mixed system of 2%-8%: 3%-12%2%-9%.

3, multi-functional decontamination composition as claimed in claim, this is characterized in that containing a kind of 2-acetoxy-benzoic acid, presses the mixed system between the 0.1%-5%.

4, multi-functional decontamination composition according to claim 1 contains a kind of 2-acetoxy-benzoic acid, the mixed system of optimized amount between 0.1%-3%.

5, according to claim 1, it is characterized in that containing the sorbitol anhydride oleate polyethers; Sorbitol anhydride oleate: C ₈-C ₁₄The alkyl oxalamide is: C ₈-C ₁₆The formed composite emulsifying system of alkyl betaine 5%-20%: 5%-25%: 1%-5%: 5%-20%.

6, according to claim 1, contain one group of emulsifying agent: sorbitol anhydride oleate polyethers: sorbitol anhydride oleate: C ₈-C ₁₄Alkyl oxalamide: C ₈-C ₁₆Alkyl betaine, optimized proportion are the formed composite emulsifying system of 8%-15%: 8%-18%: 2%-3%:8%-15%.

7, according to claim 1, it is characterized in that containing formed mixed system between trisodium phosphate 0.5%-5%, ethylenediamine tetraacetic acid (EDTA) 0.1%-3% and its pH value of the sodium phosphate salt damping fluid 5-8.

8, according to claim 1, it is characterized in that: contain glycerol 1%-5%, protolysate 1%-5%, lanolin 1%-5%, borneol 0.1-3%, formed mixed system.