CN1277576C - A kind of medicinal composition for treating typhoid fever - Google Patents

Abstract

The invention discloses a medicine composition for treating typhoid fever, which comprises ingredients of akebia, mint, rhizoma iris, calamus, white cardamom, patchouli, pinellia tuber, light black beans, magnolia bark, capillaris, fried gardenia, fried scutellaria, coptis root, forsythia, liquorice, fritillaria cirrhosa, talc, honeysuckle, semen armeniaca, purslane, perilla, isatis indigotica, raw rehmannia root, scrophularia, ophiopogon, coptis root, honeysuckle, forsythia, loquat leaf, coix seed, peony bark and red peony root. The medicine composition has the effects of clearing away heat and removing dampness, clearing the nutrient and cooling the blood, and has a good therapeutic effect on typhoid fever or paratyphoid fever caused by mutual intestinal disturbance and accumulation of dampness and heat.

Description

A kind of medicinal composition for treating typhoid fever

1. Technical field: the present invention relates to a kind of Chinese medicine for treating typhoid fever, especially a kind of pharmaceutical composition for treating typhoid fever.

2. Background technology: the pathological characteristics of typhoid fever are the proliferative response of the mononuclear phagocyte system in the whole body, characterized by persistent high fever, special poisoning state, hepatosplenomegaly, relative slow pulse, roseola, white blood cells and eosinophils The main features are intestinal bleeding and intestinal perforation as the main complications. The clinical manifestations of paratyphoid fever are similar to those of typhoid fever, and are generally milder than typhoid fever. At present, in the clinical treatment of paratyphoid and typhoid fever, Western medicine is mainly used, that is, measures such as antibacterial, anti-inflammatory, and fluid replacement are used, such as intravenous infusion of ampicillin or amikacin in 5% glucose saline, combined with chlorine Oral administration of mymycin tablets or compound sulfamethoxazole tablets, the course of treatment is long, usually about ten days, and the treatment cost is relatively high. In the clinical treatment of typhoid fever and paratyphoid fever in traditional Chinese medicine, there are mainly prescriptions such as "modified Xiaochaihu Decoction combined with Sanren Decoction" and "Ganlu Xiaodu Dan".

3. Summary of the invention: The technical problem to be solved by the present invention is to provide a medicine with the effect of clearing away heat and removing dampness, clearing camp and cooling blood, and is used for treating typhoid or paratyphoid caused by dampness and heat interacting in the colon and stomach, and accumulation of fumigation. drug.

The technical scheme that the present invention takes is that its composition scope weight share is:

Agent A:

Akebia [Akebia trifoliata (Thunb.) Koidz.var.australis (Diels) Rehd.] 1～6,

Mint [Mentha haplocalyx Briq.] 1~6,

Shegan [Belamcanda chinensis (L.) DC.] 1～6,

Iris [Acorus·tatarinowii Schott.] 1～6,

White cardamom [Amomoum kravanh Pirre ex Gagnep.] 1~6,

Patchouli [Pogostemon cablin (Blanco) Benth.] 1～6,

Ginger Pinellia [Pinellia ternata (Thunb.) Breit.] 3～8,

Light tempeh [Glycine max (L.) Merr.] 1~6,

Ginger Officinalis [Magnolia officinalis Rehd.et Wils.] 1～6,

Capillaris [Artemisia capillaris Thunb.] 5～12,

Fried gardenia [Gardenia jasminoides Ellis] 3~8,

Stir-fried skullcap [Scutellaria baicalensis Georgi] 3~8,

Coptis [Coptis chinensis Franch.] 1~5,

Forsythia suspensa (Thunb.) Vahl] 7～15,

Honeysuckle [Lonicera japonica Thunb.] 7～15,

Licorice [Glycyrrhiza uralensis Fisch.] 1~5,

Chuan Fritillaria [Fritillaria cirrhosa D.Don] 1~5,

Talc 8-18;

Agent B:

Senecio [Senecio scandens Buch.-Ham.] 5～12,

Purslane [Portulaca oleracea L.] 3～8,

Perrin [Eupatorium fortunei Turcz.] 3~8,

Folium Folium [Isatis indigotica Fort.] 15～40,

Raw rehmannia [Rehmannia glutinosa Libosch.] 10～20,

Scrophularia [Scrophularia ningpoensis Hemsl.] 10～20,

Ophiopogon japonicus (Thunb.) Ker-Gawl.] 3～8,

Coptidis 2~6, honeysuckle 10~20, forsythia 10~20,

Bamboo leaves [Lophatherum gracile Brongn.] 3～8,

Coix seed [Coix lacryma-jobi L.var.Ma-yuen(Roman.)Stapf]5～12,

Peony bark [Paeonia suffrutico Andr.] 3～8,

Radix Paeoniae Rubra [Paeonia lactiflora Pall.] 3-8.

Its optimized composition range weight share proportioning scheme is:

Agent A:

Akebia 2~4 Peppermint 2~4 Shot dried 2~4

Acorus calamus 2～4 White cardamom 2～4 Patchouli 2～4

Ginger Pinellia 4~6 Light Tempeh 2~4 Ginger Magnolia 2~4

Yin Chen 7～10 Stir-fried Gardenia 4～6 Stir-fried Scutellaria 4～6

Coptis 2～4 Forsythia 8～12 Honeysuckle 8～12

Licorice 1～3 Chuan Fritillaria 1～3 Talc 10～15;

Agent B:

Senecio 7～10 Purslane 4～6 Perrin 4～6

Daqingye 20～30 Rehmannia glutinosa 12～18 Scrophulariaceae 12～18

Ophiopogon japonicus 4～6 Coptis 3～5 Honeysuckle 12～18

Forsythia 12～18 Bamboo Leaf 4～6 Coix Seed 7～10

Cortex Moutan 4-6, Paeoniae Rubra 4-6.

Its optimal composition range weight share proportioning scheme is:

Agent A:

Akebia 3 Peppermint 3 Shoot Dried 3

Calamus 3 White Cardamom 3 Patchouli 3

Ginger Pinellia 5 Light Tempeh 3 Ginger Magnolia 3

Yin Chen 8 Stir-fried Gardenia 5 Stir-fried Scutellaria 5

Coptidis 2.5 Forsythia 10 Honeysuckle 10

Licorice 2 Fritillaria 2 Talc 12;

Agent B:

Senecio 8 Purslane 5 Perrin 5

Daqingye 25 Rehmannia 15 Scrophulariaceae 15

Ophiopogon japonicus 5 Coptis chinensis 3.5 Honeysuckle 15

Forsythia 15 Pale Bamboo Leaf 5 Coix Seed 8

Cortex Moutan 5 Radix Paeoniae Rubra 5.

The pharmaceutical composition for treating typhoid fever of the present invention can be made into granules, oral liquid or extract.

Traditional Chinese medicine believes that typhoid fever belongs to the category of dampness and temperature in Chinese medicine. It is formed by fumigation caused by dampness and heat. Dampness and heat are the external causes of the disease. Of. The medicinal composition for treating typhoid fever of the present invention uses Folium Folium Folium, Rehmannia glutinosa for clearing away heat and detoxification, cooling blood and nourishing yin as the main medicines. Folium Folium is bitter and cold, good at relieving heat and heat in the heart and stomach meridians, salty and cold enters the blood, and can cool blood and eliminate spots. , and can strengthen the phagocytic function of the body; Rehmannia glutinosa is sweet and cold in nature, clears heat and enters the nutrient, and is an essential medicine for clearing heat, cooling blood, nourishing yin, and promoting body fluid; the combination of the two medicines has the effects of clearing heat, detoxifying, cooling blood, and nourishing yin. Chuan Fritillaria, Akebia, Yin Chen, Scrophulariaceae, and Radix Ophiopogonis are the ministerial medicines for nourishing yin and clearing heat. Chuan Fritillaria is bitter and sweet, slightly cold in nature, clears away heat and moistens the lungs, and Akebia is bitter and slightly cold in nature, whichever is better The effect of clearing the heart-fire and lowering the damp-heat, the bitterness of the wormwood, the cold can clear the heat, the bitter-sweet nature of Scrophulariaceae, salty-cold, clears heat and cools the blood, nourishes yin and detoxifies, and Ophiopogon japonicus nourishes yin, moistens the lungs, nourishes the stomach and promotes body fluid, clears the heart and clears the heart bother. Accompanied by honeysuckle, forsythia, coptis, light bamboo leaves, and talc to clear away heat and detoxify, so that the evil spirits that enter the camp can be released and dissipated. It has the power of penetrating camp and turning qi; Coptis chinensis clears heat, dries dampness and detoxifies, and is used to block dampness and heat. The berberine contained in it has obvious inhibitory effect on typhoid bacillus; light bamboo leaves clear heart and expel heat, relieve restlessness and quench thirst; talc diuresis and relieve stranguria , clearing heat and relieving summer heat, damp and hot water diarrhea. In addition to other medicines for clearing away heat and detoxification, clearing camp and cooling blood, the pharmaceutical composition for treating typhoid fever of the present invention has the effects of clearing away heat and removing dampness, clearing camp and cooling blood, and can treat diseases caused by dampness and heat in the colon and stomach and accumulation of fumigation. It is very curative for typhoid or paratyphoid fever. The drug was used clinically and treated a total of 395 cases of typhoid or paratyphoid or both, of which 354 cases were markedly effective, 23 cases were effective, 13 cases were improved, and 5 cases were ineffective, with a total effective rate of 98.7%.

Fourth, the specific implementation method:

Example 1: Take 1 gram of Mutong, 1 gram of Peppermint, 6 grams of Shegan, 1 gram of Shichangpu, 1 gram of White Cardamom, 6 grams of Huoxiang, 3 grams of Jiang Pinellia, and Light Tempeh 1 gram, 6 grams of ginger officinalis, 5 grams of capillary, 3 grams of fried gardenia, 8 grams of fried scutellaria, 1 gram of berberine, 7 grams of forsythia, 15 grams of honeysuckle, 1 gram of Chuan Fritillaria, 1 gram of licorice, and 18 grams of talc. Put it into water (talc is wrapped with gauze), and the water should exceed two horizontal fingers of the medicinal material. After decocting with low heat, filter it to become the first soup, add water to the medicinal residue and continue to decoct, filter it to become the second soup. Mixing the first soup and the second soup becomes the A agent.

Take 5 grams of Senecio, 3 grams of Purslane, 8 grams of Peilan, 15 grams of Daqing Ye, 20 grams of Rehmannia glutinosa, 20 grams of Scrophulariaceae, 3 grams of Radix Ophiopogon, 2 grams of Coptidis gram, 20 grams of honeysuckle, 10 grams of forsythia, 3 grams of light bamboo leaves, 12 grams of coix seed, 3 grams of Moutan bark, 3 grams of red peony root, put them in water, and decoct at a degree of water exceeding two horizontal fingers of the medicinal material. Finally, filter to become the first soup, add water to the dregs and continue to decoct, filter to become the second soup, and mix the first soup and the second soup to become B agent.

The above dosage is the daily dosage for an adult patient. When taking it, divide dose A into two portions, and take one portion each morning and noon; divide dose B into two portions, and take one portion each afternoon and evening, and take three consecutive doses. Days will heal.

If the above agents A and B are concentrated, they can be made into granules or extracts, which can be taken after mixing with boiling water.

Example 2: Take 6 grams of Akebia, 6 grams of Peppermint, 1 gram of Shegan, 6 grams of Shichangpu, 6 grams of white cardamom, 1 gram of Huoxiang, 8 grams of Jiang Pinellia, and light tempeh. 6 grams, 1 gram of ginger officinalis, 12 grams of capillary, 8 grams of fried gardenia, 3 grams of fried scutellaria, 5 grams of berberine, 15 grams of forsythia, 7 grams of honeysuckle, 5 grams of fritillaria, 5 grams of licorice, and 8 grams of talc. Put it into water (the talc is wrapped with gauze), put it into the water, and the water should exceed two horizontal fingers of the medicinal material. After decocting with low heat, filter it to become the first soup, add water to the medicinal residue and continue to decoct, and filter it to become the second soup. First soup, mix the first soup and the second soup to become A agent.

Take 12 grams of Senecio, 8 grams of purslane, 3 grams of Peilan, 40 grams of Daqingye, 10 grams of rehmannia, 10 grams of Scrophulariaceae, 8 grams of Radix Ophiopogon, 6 grams of Coptis chinensis. gram, 10 grams of honeysuckle, 20 grams of forsythia, 8 grams of light bamboo leaves, 5 grams of coix seed, 8 grams of Moutan bark, and 8 grams of red peony. Finally, filter to become the first soup, add water to the dregs and continue to decoct, filter to become the second soup, and mix the first soup and the second soup to become B agent.

The method of administration and dosage are the same as above.

Example 3: Take 2 grams of Akebia, 2 grams of Peppermint, 4 grams of Shegan, 2 grams of Shichangpu, 2 grams of white cardamom, 4 grams of Huoxiang, 4 grams of Jiang Pinellia, and light tempeh. 2 grams, 4 grams of ginger officinalis, 7 grams of capillary, 4 grams of fried gardenia, 6 grams of fried scutellaria, 2 grams of berberine, 8 grams of forsythia, 12 grams of honeysuckle, 1 gram of fritillaria, 1 gram of licorice, and 15 grams of talc. Put it into water (the talc is wrapped with gauze), put it into the water, and the water should exceed two horizontal fingers of the medicinal material. After decocting with low heat, filter it to become the first soup, add water to the medicinal residue and continue to decoct, and filter it to become the second soup. First soup, mix the first soup and the second soup to become A agent.

Take 7 grams of Senecio, 4 grams of Purslane, 6 grams of Peilan, 20 grams of Folium Folium, 18 grams of Rehmannia, 18 grams of Scrophulariaceae, 4 grams of Radix Ophiopogon, 3 grams of Coptidis gram, 18 grams of honeysuckle, 12 grams of forsythia, 4 grams of light bamboo leaves, 10 grams of coix seed, 4 grams of Moutan bark, 4 grams of red peony root, put them in water, and decoct with a degree of water exceeding two horizontal fingers of the medicinal material. Finally, filter to become the first soup, add water to the dregs and continue to decoct, filter to become the second soup, and mix the first soup and the second soup to become B agent.

The method of administration and dosage are the same as above.

Example 4: Take 4 grams of Akebia, 4 grams of mint, 2 grams of Shegan, 4 grams of Shichangpu, 4 grams of white cardamom, 2 grams of Huoxiang, 6 grams of ginger pinellia, and light tempeh 4 grams, 2 grams of ginger officinalis, 10 grams of capillary, 6 grams of fried gardenia, 4 grams of fried scutellaria, 4 grams of berberine, 12 grams of forsythia, 8 grams of honeysuckle, 3 grams of fritillaria, 3 grams of licorice, and 10 grams of talc. Put it into water (the talc is wrapped with gauze), put it into the water, and the water should exceed two horizontal fingers of the medicinal material. After decocting with low heat, filter it to become the first soup, add water to the medicinal residue and continue to decoct, and filter it to become the second soup. First soup, mix the first soup and the second soup to become A agent.

Take 10 grams of Senecio, 6 grams of purslane, 4 grams of Peilan, 30 grams of Daqingye, 12 grams of rehmannia, 12 grams of Scrophulariaceae, 6 grams of Radix Ophiopogon, 5 grams of Coptidis gram, 12 grams of honeysuckle, 18 grams of forsythia, 6 grams of light bamboo leaves, 7 grams of coix seed, 6 grams of peony bark, 6 grams of red peony root, put them in water, and decoct with a degree of water exceeding two horizontal fingers of the medicinal materials. Finally, filter to become the first soup, add water to the dregs and continue to decoct, filter to become the second soup, and mix the first soup and the second soup to become B agent.

The method of administration and dosage are the same as above.

Example 5: Take 3 grams of Akebia, 3 grams of Peppermint, 3 grams of Shegan, 3 grams of Shichangpu, 3 grams of white cardamom, 3 grams of Huoxiang, 5 grams of Jiang Pinellia, and light tempeh. 3 grams, 3 grams of ginger officinalis, 8 grams of capillary, 5 grams of fried gardenia, 5 grams of fried scutellaria, 2.5 grams of berberine, 10 grams of forsythia, 10 grams of honeysuckle, 2 grams of Chuan Fritillaria, 2 grams of licorice, 12 grams of talc. Put it into water (the talc is wrapped with gauze), put it into the water, and the water should exceed two horizontal fingers of the medicinal material. After decocting with low heat, filter it to become the first soup, add water to the medicinal residue and continue to decoct, and filter it to become the second soup. First soup, mix the first soup and the second soup to become A agent.

Take 8 grams of Senecio, 5 grams of Purslane, 5 grams of Peilan, 25 grams of Daqing Ye, 15 grams of Rehmannia, 15 grams of Scrophulariaceae, 5 grams of Radix Ophiopogon, 3.5 grams of Coptidis gram, 15 grams of honeysuckle, 15 grams of forsythia, 5 grams of light bamboo leaves, 8 grams of coix seed, 5 grams of peony bark, and 5 grams of red peony root, put them in water, and decoct at a degree of water exceeding two horizontal fingers of the medicinal material. Finally, filter to become the first soup, add water to the dregs and continue to decoct, filter to become the second soup, and mix the first soup and the second soup to become B agent.

The method of administration and dosage are the same as above.

Claims (3)

1, a kind of pharmaceutical composition for the treatment of typhoid fever is characterized in that making its raw materials of effective components and consists of:

The A agent:

Caulis Akebiae 1～6 Herba Menthae 1～6 Rhizoma Belamcandae 1～6

Rhizoma Acori Graminei 1～6 Fructus Amomi Rotundus 1～6 Herba Pogostemonis 1～6

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3～8 Semen Sojae Preparatums 1～6 Cortex Magnoliae Officinalis(processed with ginger) 1～6

Herba Artemisiae Scopariae 5～12 Fructus Gardeniae (parched) 3～8 Radix Scutellariae (parched) 3～8

Rhizoma Coptidis 1～5 Fructus Forsythiae 7～15 Flos Loniceraes 7～15

Radix Glycyrrhizae 1～5 Bulbus Fritillariae Cirrhosae 1～5 Talcum 8～18;

The B agent:

Herba Senecionis Scandentis 5～12 Herba Portulacaes 3～8 Herba Eupatoriis 3～8

Folium Isatidis 15～40 Radix Rehmanniae 10～20 Radix Scrophulariaes 10～20

Radix Ophiopogonis 3～8 Rhizoma Coptidis, 2～6 Flos Loniceraes 10～20

Fructus Forsythiae 10～20 Herba Lophatheris 3～8 Semen Coiciss 5～12

Cortex Moutan 3～8 Radix Paeoniae Rubra 3～8.

2, a kind of pharmaceutical composition for the treatment of typhoid fever according to claim 1 is characterized in that making its raw materials of effective components and consists of:

The A agent:

Caulis Akebiae 2～4 Herba Menthaes 2～4 Rhizoma Belamcandae 2～4

Rhizoma Acori Graminei 2～4 Fructus Amomi Rotunduss 2～4 Herba Pogostemoniss 2～4

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4～6 Semen Sojae Preparatums 2～4 Cortex Magnoliae Officinalis(processed with ginger) 2～4

Herba Artemisiae Scopariae 7～10 Fructus Gardeniae (parched) 4～6 Radix Scutellariae (parched) 4～6

Rhizoma Coptidis 2～4 Fructus Forsythiaes 8～12 Flos Loniceraes 8～12

Radix Glycyrrhizae 1～3 Bulbus Fritillariae Cirrhosae 1～3 Talcum 10～15;

The B agent:

Herba Senecionis Scandentis 7～10 Herba Portulacaes 4～6 Herba Eupatoriis 4～5

Folium Isatidis 20～30 Radix Rehmanniae 12～18 Radix Scrophulariaes 12～18

Radix Ophiopogonis 4～6 Rhizoma Coptidis, 3～5 Flos Loniceraes 12～18

Fructus Forsythiae 12～18 Herba Lophatheris 4～6 Semen Coiciss 7～10

Cortex Moutan 4～6 Radix Paeoniae Rubra 4～6.

3, a kind of pharmaceutical composition for the treatment of typhoid fever according to claim 1 and 2 is characterized in that making its raw materials of effective components and consists of:

The A agent:

Caulis Akebiae 3 Herba Menthaes 3 Rhizoma Belamcandae 3

Rhizoma Acori Graminei 3 Fructus Amomi Rotunduss 3 Herba Pogostemoniss 3

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 Semen Sojae Preparatums 3 Cortex Magnoliae Officinalis(processed with ginger) 3

Herba Artemisiae Scopariae 8 Fructus Gardeniae (parched) 5 Radix Scutellariae (parched) 5

Rhizoma Coptidis 2.5 Fructus Forsythiaes 10 Flos Loniceraes 10

Radix Glycyrrhizae 2 Bulbus Fritillariae Cirrhosaes 2 Talcums 12;

The B agent:

Herba Senecionis Scandentis 8 Herba Portulacaes 5 Herba Eupatoriis 5

Folium Isatidis 25 Radix Rehmanniae 15 Radix Scrophulariaes 15

Radix Ophiopogonis 5 Rhizoma Coptidis, 3.5 Flos Loniceraes 15

Fructus Forsythiae 15 Herba Lophatheris 5 Semen Coiciss 8

Cortex Moutan 5 Radix Paeoniae Rubra 5.