CN1271590A - Medical capsule for curing aplastic anemia and its preparing process - Google Patents
Medical capsule for curing aplastic anemia and its preparing process Download PDFInfo
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Abstract
A medical capsule for treating aplastic anemia is prepared from several tens of Chinese medicinal materials including dried rehmannia root, prepared rehmannia root, dogwood fruit, psoralea fruit, spatholobus stem, tortoise plastron, etc. proportionately through weathering, baking and stir-frying, screening, mixing, stirring and loading in capsules, and serves to improve the hematopoietic function of bone marrow in short time. Its advantages are high total effective rate up to 97.5%, rich raw materials, simple preparing process, high safety and curative effect and no toxic by-effect.
Description
The present invention relates to a kind of medicine for the treatment of aplastic anemia---be good for prescription of marrow curing capsule and preparation method thereof.
Aplastic anemia is called for short " aplastic anemia ", is a kind of multiple disease, belongs to Chinese medicine " asthenia ", " mass formed by blood stasis " category.Be a kind of be that the blood of characteristics is disease owing to hemopoietic hypofunction of marrow causes anemia, hemorrhage, infection, pancytopenia.Its cause of disease complexity, serious threat the healthy of the mankind.Medical circle is to the not unified understanding of pathogeny of aplastic anemia at present, and routine administration homemade as " promoting hemogenesis for aplastic anemia tablet ", " stanozolol " etc. were a course of treatment with one month generally.But this class medicine has damage to the human liver function, and side effect is big." SHENGBAINENG " of external as U.S. etc. though curative effect is better than homemade medicine, cost an arm and a leg, so clinical being very limited.
The present invention screens meticulously through inventor's clinical verification in nearly 30 years, has studied, formulated the optimal drug prescription for the treatment of dissimilar aplastic anemia---strong marrow curing capsule and preparation method thereof.Serve as the main good effect that obtains mainly with the strong marrow hemopoietic of the kidney invigorating.Modern pharmacological research helps the kidney medicine can promote the hemopoietic function of bone marrow stem cell, how to use the kidney warming sun medicine to obtain the key of better curative effect often in prescription.The aplastic anemia patient is generally except that there being the kidney yin kidney yang to lose the void, the deficiency of both QI and blood of holding concurrently more, the selected kidney yang medicine that helps should be noted temperature and not dry, in the blood in love extremely.
The objective of the invention is to, make the patient in the short treatment phase, effectively improve its hemopoietic function of bone marrow, improve hemoglobin in the back of taking medicine; Strong marrow curing capsule is taken medicine easy, without any side effects; Medicine source abundance, it is convenient to gather, and preparation is simple, and is economical and practical; It is a kind of Chinese medicine preparation of novel treatment aplastic anemia.
Main points of the present invention are that strong marrow curing capsule is by the Chinese herbal medicine Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, wide Cornu Bovis seu Bubali, the mountain cornel, Fructus Lycii, Herba Selaginellae, outstanding order wood fruit, Semen Cuscutae, Fructus Psoraleae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Angelicae Sinensis, Cortex Moutan, the Radix Paeoniae Alba, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Polygonati, Flos Lonicerae, Herba Leonuri, Caulis Spatholobi, Carapax et Plastrum Testudinis, Colla cornus cervi, Herba Ecliptae, Pu's Huang, charred Radix Sanguisorbae, the Radix Scutellariae charcoal, charred Nodus Nelumbinis Rhizomatis, Herba Agrimoniae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Ophiopogonis, Radix Codonopsis, Radix Ginseng, the Radix Astragali, Semen Ziziphi Spinosae, the Radix Polygoni Multiflori, Cortex Cinnamomi, Fructus Ligustri Lucidi, Herba Epimedii, system Fu, Rhizoma Zingiberis, Herba Cistanches, unit's meat, sorosis etc. are formulated.Its preparing process is: with the said medicine oven dry, according to dissimilar strong marrow curing capsule prescriptions, by the preparation of 1: 1 mixed of drug weight, be ground into fine powder, stir, after 120 purpose sieve screens, divide in " O " number capsule of packing into, every 0.35-0.5g, strong marrow curing capsule.
The present invention works out four types strong marrow curing capsule through repetition test.The optimum formula of four kinds of mixed powders is:
Strong marrow curing capsule I number: Radix Rehmanniae Preparata, Herba Agrimoniae, Radix Et Rhizoma Rhei, wide Cornu Bovis seu Bubali, Herba Ecliptae, outstanding order wood fruit, Pu's Huang, charred Radix Sanguisorbae, Radix Scutellariae charcoal, charred Nodus Nelumbinis Rhizomatis;
Strong marrow curing capsule II number: mountain cornel, Herba Selaginellae, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Caulis Spatholobi, Cortex Moutan, Flos Lonicerae, Radix Ophiopogonis, Herba Leonuri;
Strong marrow curing capsule III number: the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Ziziphi Spinosae, Radix Paeoniae Rubra, Flos Lonicerae;
Strong marrow curing capsule IV number: Fructus Psoraleae, the Radix Polygoni Multiflori, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Ginseng, Carapax et Plastrum Testudinis, Cortex Cinnamomi, Fructus Lycii, Semen Cuscutae, Fructus Ligustri Lucidi, Herba Epimedii, system Fu, Rhizoma Zingiberis, Herba Cistanches, Colla cornus cervi, first meat, sorosis.
The usage and the consumption of strong marrow curing capsule: morning, noon and afternoon every day three times, each 20-30 grain, children's reduces by half, and one month is a course of treatment.
Storage practice: aeration-drying, preserve in the cool.
Useful life: 2 years.
Embodiment 1:
I number prescription of strong marrow curing capsule: Radix Rehmanniae Preparata 15g, Herba Agrimoniae 15g, Radix Et Rhizoma Rhei 15g, wide Cornu Bovis seu Bubali 15g, Herba Ecliptae 15g, outstanding order wood fruit 15g, Pu yellow 15g, charred Radix Sanguisorbae 15g, Radix Scutellariae charcoal 15g, charred Nodus Nelumbinis Rhizomatis 15g;
Preparation method: with after the said medicine oven dry by weight ratio, be ground into fine powder, stir, with 120 purpose sieve screens after, divide in " O " number capsule of packing into, every 0.5g, promptly make be good for marrow curing capsule I number 300.
Embodiment 2: strong marrow curing capsule IV number: Fructus Psoraleae 4kg, Radix Polygoni Multiflori 4kg, Radix Morindae Officinalis 4kg, Cortex Eucommiae 4kg, Radix Ginseng 4kg, Carapax et Plastrum Testudinis 4kg, Cortex Cinnamomi 4kg, Fructus Lycii 4kg, Semen Cuscutae 4kg, Fructus Ligustri Lucidi 4kg, Herba Epimedii 4kg, system Fu 4kg, Rhizoma Zingiberis 4kg, Herba Cistanches 4kg, Colla cornus cervi 4kg, first meat 4kg, the sub-4kg of sorosis;
Preparation method: with after the said medicine oven dry by weight ratio, be ground into fine powder, stir, with 120 purpose sieve screens after, divide in " O " number capsule of packing into, every 0.4g, promptly make be good for marrow curing capsule IV number 170,000.
Therapeutic effect of the present invention and example:
Through inventor's clinical verification in nearly 30 years, strong marrow curing capsule is used for the treatment of aplastic anemia, and total effective rate can reach more than 97.5%.Now lifting 1200 examples is proved, male's 725 examples wherein, and women's 475 examples, the age is all at 9-71 between year.The highest 78g/l of the minimum 15g/l of hemoglobin in patient's period of disease; Leukocyte is lower than 3 * 10
9/ l; Platelet minimum 16 * 10
9/ l is the highest by 68 * 10
9/ l.Male's 725 cases statistics effective percentage reaches 98.4%:
Women's 475 cases statistics effective percentage reaches 97.5%:
| Age (year) | Case load (individual) | Cure number (individual) | Alleviate number (individual) | Part is alleviated number (individual) | Invalid number (individual) |
| 9-21 | ??207 | ??85 | ??70 | ??51 | ????1 |
| 22-53 | ??324 | ??82 | ??130 | ??107 | ????5 |
| 54-71 | ??194 | ??58 | ??90 | ??41 | ????5 |
| Effective percentage | ??31％ | ??40％ | ??27.4％ | ????1.6％ |
| Age (year) | Case load (individual) | Cure number (individual) | Alleviate number (individual) | Part is alleviated number (individual) | Invalid number (individual) |
| ??9-27 | ??149 | ??49 | ??63 | ??34 | ??3 |
| ??28-41 | ??214 | ??76 | ??87 | ??49 | ??2 |
| ??42-71 | ??112 | ??51 | ??42 | ??14 | ??5 |
| Effective percentage | ??37％ | ??40％ | ??20.5％ | ??2.5％ |
Criterion of therapeutical effect adopts the 4th standard that the aplastic anemia meeting is drafted in 1997.
Cure: anemia, bleeding disappear; Male's hemoglobin 120g/l, women's hemoglobin 100g/l; Leukocyte 4 * 10
9/ l; Platelet 80 * 10
9More than/the l, follow up a case by regular visits to 1 year no recidivist.
Alleviate: anemia, bleeding disappear hemoglobin male 120g/l, women 100g/l; Leukocyte 35 * 10
9About/l; Platelet has to a certain degree to be recovered, and follows up a case by regular visits to stable disease half a year.
Part is alleviated: anemia, bleeding are clearly better, and do not transfuse blood, and the hemoglobin preceding peripheral hemogram of treatment slightly increases, and keeps and does not fall the person in three months.
Invalid: as not reach every index after the treatment, the symptom person that do not improve.
In 1200 cases, the shortest 4 courses of treatment, the longest 18 courses of treatment.
Model case 1: Cui Jinhe, the man, 68 years old, grand people, nineteen ninety first visit on August 21 were returned by end, Hebei province county.Medical history: be diagnosed as aplastic anemia in Shijiazhuang hematopathy hospital in May, 1989, not good enough through 5 months therapeutic effect, and about 10-15 days blood transfusion 400ml introduce the here diagnosis and treatment through the ward mate.
Symptom: shallow complexion, dizzy weak, heart contraction is breathed hard, gingival hemorrhage, the shirtfront purpura becomes thin, deep-thready pulse.
Chemical examination: platelet 28 * 10
9/ l, erythrocyte 1.35 * 10
12/ l, hemoglobin 38g/l, leukocyte 0.98 * 10
9/ l, lymphocyte 86 is examined and is the deficiency of both YIN and YANG type.Through taking strong marrow curing capsule, the morning, noon and afternoon are respectively obeyed 25, and after the course of treatment, subjective symptoms makes moderate progress, and spirit takes a turn for the better to some extent, and purpura obviously reduces.Result of laboratory test is: platelet 35 * 10
9/ l, erythrocyte 1.75 * 10
12/ l, hemoglobin 45g/l, leukocyte 2.5 * 10
9/ l, lymphocyte 74.Continue to take medicine after two courses of treatment its platelet 40 * 10
9/ l, erythrocyte 2.9 * 10
12/ l, hemoglobin 85g/, leukocyte 3.4 * 10
9/ l continues to take medicine and consolidates curative effect, and in February, 1991, it is normal that hemogram recovers, and do not have any subjective symptoms, and medullary cell inspection three is all normal, follows up a case by regular visits to after 5 years and does not see recurrence.
Model case 2: Jiang Xiangli, man, 13 years old, Hebi City people, first visit on February 15 in 1994.Medical history: be diagnosed as aplastic anemia at the Chinese Academy of Sciences's hematopathy institute October nineteen ninety, and therapeutic effect is not good enough through the man medical institutions of number, and per two months blood transfusion 400ml introduce here to go to a doctor through kith and kin.
Symptom: have a dizzy spell, tinnitus is forgetful, insomnia and dreamful sleep, and dysphoria with feverish sensation in the chest palms and soles, flushing night sweat, the red tongue tongue is few, thready and rapid pulse.
Chemical examination: platelet 40 * 10
9/ l, erythrocyte 1.85 * 10
12/ l, hemoglobin 48g/l, leukocyte 1.95 * 10
9/ l, neutral leaflet 22, lymphocyte 78 is examined and is the yin deficiency type.With strong marrow curing capsule II number, III number, IV nourishing the liver and kidney, replenishing YIN and removing heat is main, and every kind of medicine is early, middle and late obeys 25.After on March 15 course of treatment, symptom has improvement greatly, and result of laboratory test is: platelet 64 * 10
9/ l, erythrocyte 2.85 * 10
12/ l, hemoglobin 68l, leukocyte 3.4 * 10
9/ l, neutral leaflet 34, lymphocyte 66.Continue to take strong marrow curing capsule II number, III number, IV number.After on May 15 three courses of treatment, above-mentioned symptom disappears substantially, result of laboratory test: platelet 107 * 10
9/ l, erythrocyte 3.7 * 10
12/ l, hemoglobin 100g/l, leukocyte 4.1 * 10
9/ l, neutral leaflet 38, lymphocyte 62.Continuing the after treatment of taking medicine, after three courses of treatment, is all normal through medullary cell inspection three, does not have any subjective symptoms, normally goes to school, and follows up a case by regular visits to and does not see recurrence so far.
Model case 3: Liu Yuming, man, 38 years old, Fu Yang people from city, first visit on August 28 in 1993.Medical history: be diagnosed as aplastic anemia in the Henan medical college in May, 1987, and through the nearly 7 years treatment of how tame medical institutions, effect is all undesirable, introduces the here diagnosis and treatment through the ward mate.
Symptom: coldness of the body with chills, extremities being not warm, lethargy, the lazy speech of breathing hard, complexion is white all of a sudden, and onyx does not have the pool, anorexia and loose stool, tongue is white, deep-thready pulse.
Chemical examination: platelet 41 * 10
9/ l, erythrocyte 2.3 * 10
12/ l, hemoglobin 60g/1, leukocyte 2.4 * 10
9/ l, neutral leaflet 36, lymphocyte 64 is examined and is deficiency of yang type.With strong marrow curing capsule I number, III number, the IV nourishing kidney is supporing yang, warming middle-JIAO and strengthening the spleen is main, every kind of medicine is early, middle and late obeys 20.JIUYUE 28 days is after course of treatment, and symptom is slightly improved, and result of laboratory test is: platelet 43 * 10
9/ l, erythrocyte 2.3 * 10
12/ l, hemoglobin 60g/l, leukocyte 2.5 * 10
9/ l, neutral leaflet 38, lymphocyte 62.Continue every kind of model medicine of this medicine of clothes and add 30 of great achievements.After on November 28 4 courses of treatment, symptom is obviously improved, and result of laboratory test is: platelet 93 * 10
9/ 1, erythrocyte 4.9 * 10
12/ l, hemoglobin 121g/l, leukocyte 3.9 * 10
9/ l, neutral leaflet 44, lymphocyte 56.Continue the after treatment that takes this medicine, no abnormal on March 15th, 1994 through the medullary cell inspection, follow up a case by regular visits to and do not have recurrence so far.
The invention has the advantages that strong marrow curing capsule belongs to Chinese medicine preparation, the medicine source is sufficient, and it is convenient to gather, and method for making is easy, and is economical and practical, and finished product adopts capsule dress system, takes simple. Be used for hindering patient's treatment, safety, reliable, convenient, evident in efficacy, without any side effects is to treat the again desirable medicine of barrier again.
Claims (5)
1. treat strong marrow curing capsule of aplastic anemia and preparation method thereof for one kind, it is characterized in that strong marrow curing capsule is by the Chinese herbal medicine Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, wide Cornu Bovis seu Bubali, the mountain cornel, Fructus Lycii, Herba Selaginellae, outstanding order wood fruit, Semen Cuscutae, Fructus Psoraleae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Angelicae Sinensis, Cortex Moutan, the Radix Paeoniae Alba, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Polygonati, Flos Lonicerae, Herba Leonuri, Caulis Spatholobi, Carapax et Plastrum Testudinis, Colla cornus cervi, Herba Ecliptae, Pu's Huang, charred Radix Sanguisorbae, the Radix Scutellariae charcoal, charred Nodus Nelumbinis Rhizomatis, Herba Agrimoniae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Ophiopogonis, Radix Codonopsis, Radix Ginseng, the Radix Astragali, Semen Ziziphi Spinosae, the Radix Polygoni Multiflori, Cortex Cinnamomi, Fructus Ligustri Lucidi, Herba Epimedii, system Fu, Rhizoma Zingiberis, Herba Cistanches, unit's meat, sorosis etc. are formulated.Its preparing process is: with said medicine oven dry, the strong marrow curing capsule prescription according to dissimilar by the preparation of drug weight mixed, is ground into fine powder, stirs, after the sieve screen, divide in the capsule of packing into, strong marrow curing capsule.
2. strong marrow curing capsule of treatment aplastic anemia according to claim 1 and preparation method thereof is characterized in that, said dissimilar strong marrow curing capsule prescription has four types, and the optimum formula of four kinds of mixed powders is:
Strong marrow curing capsule I number: Radix Rehmanniae Preparata, Herba Agrimoniae, Radix Et Rhizoma Rhei, wide Cornu Bovis seu Bubali, Herba Ecliptae, outstanding order wood fruit, Pu's Huang, charred Radix Sanguisorbae, Radix Scutellariae charcoal, charred Nodus Nelumbinis Rhizomatis;
Strong marrow curing capsule II number: mountain cornel, Herba Selaginellae, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Caulis Spatholobi, Cortex Moutan, Flos Lonicerae, Radix Ophiopogonis, Herba Leonuri;
Strong marrow curing capsule III number: the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Semen Ziziphi Spinosae, Radix Paeoniae Rubra, Flos Lonicerae;
Strong marrow curing capsule IV number: Fructus Psoraleae, the Radix Polygoni Multiflori, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Ginseng, Carapax et Plastrum Testudinis, Cortex Cinnamomi, Fructus Lycii, Semen Cuscutae, Fructus Ligustri Lucidi, Herba Epimedii, system Fu, Rhizoma Zingiberis, Herba Cistanches, Colla cornus cervi, first meat, sorosis.
3. according to strong marrow curing capsule of claim 1,2 described treatment aplastic anemia and preparation method thereof, it is characterized in that said medicine oven dry back weight proportion is 1: 1.
4. according to strong marrow curing capsule of claim 1,2 described treatment aplastic anemia and preparation method thereof, it is characterized in that said with medicated powder sieve screen, used sieve is 120 eye mesh screens.
5. according to strong marrow curing capsule of claim 1,2 described treatment aplastic anemia and preparation method thereof, it is characterized in that, saidly medicated powder is incapsulated number capsule into " O ", every dress 0.35-0.5g.
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| CN100462101C (en) * | 2006-11-24 | 2009-02-18 | 何新超 | Medicament for treating aplastic anemia |
| CN101401891B (en) * | 2008-11-10 | 2011-04-27 | 张新丽 | Traditional Chinese medicine decoction for treating aplastic anemia |
| CN102727765A (en) * | 2012-05-31 | 2012-10-17 | 刘敏 | Internally-used medicine for treating aplastic anemia by nourishing yin and yang |
| CN108175538A (en) * | 2018-01-25 | 2018-06-19 | 朱耀斌 | A kind of Deep Hypothermia Circulatory Arrest rat animal model |
| US10058580B2 (en) * | 2000-03-09 | 2018-08-28 | Yale University | Herbal composition PHY906 and its use in chemotherapy |
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1999
- 1999-04-22 CN CN 99105876 patent/CN1271590A/en active Pending
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| CN100462101C (en) * | 2006-11-24 | 2009-02-18 | 何新超 | Medicament for treating aplastic anemia |
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