CN1269217A - Bagged blood circulation-activating and obstruction-dredging granule and its preparation - Google Patents
Bagged blood circulation-activating and obstruction-dredging granule and its preparation Download PDFInfo
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- CN1269217A CN1269217A CN 99101999 CN99101999A CN1269217A CN 1269217 A CN1269217 A CN 1269217A CN 99101999 CN99101999 CN 99101999 CN 99101999 A CN99101999 A CN 99101999A CN 1269217 A CN1269217 A CN 1269217A
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- root
- radix
- extract
- peregal
- medicine
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 210000004369 blood Anatomy 0.000 title description 6
- 239000008280 blood Substances 0.000 title description 3
- 239000008187 granular material Substances 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims abstract description 12
- 239000004863 Frankincense Substances 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 8
- 238000010992 reflux Methods 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims description 21
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 241000903946 Clematidis Species 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 9
- 241001057584 Myrrha Species 0.000 claims description 8
- 230000003213 activating effect Effects 0.000 claims description 7
- 230000017531 blood circulation Effects 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- -1 reflux Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 3
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 2
- 240000007551 Boswellia serrata Species 0.000 abstract 2
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 2
- 244000306301 Caesalpinia sappan Species 0.000 abstract 2
- 235000015162 Caesalpinia sappan Nutrition 0.000 abstract 2
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 abstract 2
- 241000208809 Carthamus Species 0.000 abstract 2
- 241000218158 Clematis Species 0.000 abstract 2
- 240000007311 Commiphora myrrha Species 0.000 abstract 2
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 2
- 241000878003 Dendrolycopodium obscurum Species 0.000 abstract 2
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 2
- 235000017276 Salvia Nutrition 0.000 abstract 2
- 240000007164 Salvia officinalis Species 0.000 abstract 2
- 235000019441 ethanol Nutrition 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 206010061363 Skeletal injury Diseases 0.000 abstract 1
- 239000002357 osmotic agent Substances 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 4
- 230000000399 orthopedic effect Effects 0.000 description 4
- 230000004087 circulation Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000002389 essential drug Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a medicine for external application for curing bone injury, and its composition includes (wt%) sappan wood 5-20, carthamus 2-15, salvia root 10-20, frankincense 5-10, myrrh 5-10, notopterygium root 5-15, clematis root 10-20, ground pine 2-15, acanthopanax root bark 10-20 and dermatic osmotic agent peregal O. Its preparation method includes the following steps: soaking sappan wood, salvia root, frankincense, myrrh and clematis root by adding ethyl alcohol, reflux extraction to obtain alcohol liquid extract, adding water in medicinal residue and extracting to obtain aqueous liquid extract, combining them and concentrating, adding Peregal O and pulverizing carthamus, notoplerygium root, acanthopanax root bark and ground pine to obtain medicinal powder, then fully mixing them and granulating to obtain the invented product.
Description
The present invention relates to a kind of orthopedics department external used medicine, mainly propose a kind of activating blood circulation and unblocking obstruction bagged steeping drug and preparation method.
The Therapeutic Method of orthopedics and traumatology of Chinese medicine is rich and varied, external washout with traditional Chinese herbs be traditional, by a kind of Therapeutic Method of widespread usage.But orthopedics department washout medicine all is directly to decoct to smoke with the prescription crude drug to wash so far, and medicine is handled without extracting, and does not have certain dosage form, and inconvenience is used in transportation storage inconvenience.
The prescription of tradition washout decoct is different and each tame medication custom is different to disease because of institute, but essential drugs concentrates on the following aspects: 1), blood-activating stasis-removing kind, and as Radix Salviae Miltiorrhizae, Lignum Sappan, Flos Carthami, Olibanum, Myrrha etc.2), the expelling wind and removing dampness class, as Radix Clematidis, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis, Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Lycopodii, Cortex Acanthopancis etc.3), diaphoretic medicine, as Herba Ephedrae, Ramulus Cinnamomi, Herba Asari, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii and Folium Artemisiae Argyi, Fructus Foeniculi etc.
Bagged steeping drug is based on the Chinese medicine decoction made from powder, and the medicine processed is become granule, according to dosage is sub-packed in a kind of novel form in the filter paper bag that the good anti-boiling water of permeability soaks.In 5223 products of 43 kinds of dosage forms that record in " national Chinese patent medicine product collection " that 1989 publish, bagged steeping drug has only 7, and 94 years document computers are so far consulted, and the research paper of relevant bagged steeping drug has reached 101 pieces.Experimental study proves that constantly the effective ingredient leaching rate in the bagged steeping drug is significantly higher than decoct, and can make drug dose reduce the curative effect raising.
Orthopedics department washout medicine is original, coarse in order to overcome, the difficult control of quality, and curative effect can not guarantee, uses shortcomings such as storage, transportation inconvenience.The present invention optimizes the conventional Chinese medicine prescription, formulates extraction process through experimental study, selects the suitable skin penetrating agent, is prepared from.
The composition of medicine of the present invention and proportion are by medicine 100% (percentage by weight): Lignum Sappan 5～20, Flos Carthami 2～15, Radix Salviae Miltiorrhizae 10～20, Olibanum 5～10, Myrrha 5～10, Rhizoma Et Radix Notopterygii 5～15, Radix Clematidis 10～20, Herba Lycopodii 2～15, Cortex Acanthopancis 10～20, the auxilliary agent peregal 02～10 that adds.
Full the side is a monarch drug to prescription of the present invention with the promoting the circulation of blood blood stasis dispelling of Lignum Sappan, reducing swelling and alleviating pain effect commander, and being aided with Flos Carthami, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, to strengthen its main effect be ministerial drug; Be aided with Rhizoma Et Radix Notopterygii, Radix Clematidis, Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral again, Cortex Acanthopancis is mended the Liver and kidney QI and blood deficiency of prolonged illness, with strong muscles and bones.Its medication is concentrated, and promoting the circulation of blood blood stasis dispelling power is special, and it is clear and definite to suit the medicine to the illness, and it plays the promoting the circulation of blood blood stasis dispelling, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain effect.For making medicine see through local skin as early as possible, give full play to its drug effect, added surfactant peregal 0, play short Transdermal absorption effect.
The preparation method of activating blood circulation and unblocking obstruction bagged steeping drug of the present invention:
With Flos Carthami, Rhizoma Et Radix Notopterygii, Cortex Acanthopancis, that Herba Lycopodii is ground into medicated powder is standby; Lignum Sappan, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Radix Clematidis are added soak with ethanol, reflux, extract, filter alcohol extract, add in the medicinal residues water and reflux, extract, filter the water extract; Merge with the water extract behind the alcohol extract recovery ethanol, concentrated back adds peregal 0 and the above-mentioned medicated powder that got fully mixes the back granulation.
The bagged steeping drug that the present invention proposes has following characteristics:
1, compare with corresponding decoct, medicine crude drug consumption of the present invention reduces half, can save crude drug.
2, character from effective ingredient is considered in the medication preparation process of the present invention, the method that has adopted pure moisture to get indescribably, this extraction process is preferably to get through the test of four factors, three horizontal quadratures, the extraction rate of especially fat-soluble effective ingredient is significantly higher than water decoction, so drug effect also is better than water decoction.
3, added suitable surfactant peregal 0 in the medicine of the present invention, add the total transmitance of its effective ingredient of back and be higher than the latter 42.7%, the selection of this surfactant and consumption are determined by the transdermal test in vitro absorption test, test is to different surfaces activating agent tween-8 °, peregal 0, factors such as emulsifying agent 0P～10 and different additions compare, and existing method is an optimum selection.
4, pharmacodynamics proves, this invention medicine anti-inflammatory analgesic effect significantly is better than blank and former decoct medicine.
5, medicine of the present invention adopts the filter bag packing, compares with identical decoct, is convenient to store, transport, and the patient that is more convenient for uses.During use, the patient only needs medicine is together placed in the appropriate vessel together with filter bag, add hot water towards moltenly can doublely smoke, wash, coating method uses simultaneously.
6, drug quality of the present invention is controlled, and scientific and reasonable quality standard is arranged.
7, composition is nontoxic Chinese medicine in the medicine of the present invention, and is safe in utilization, has no side effect.
Embodiment 1
Component and consumption: press medicine 100% (percentage by weight)
Lignum Sappan 10, Flos Carthami 6, Radix Salviae Miltiorrhizae 15, Olibanum 6, Myrrha 6, Rhizoma Et Radix Notopterygii 10, Radix Clematidis 16, Cortex Acanthopancis 16, Herba Lycopodii 10
Assist and add agent: peregal 05
Preparation method: Flos Carthami, Herba Lycopodii, Rhizoma Et Radix Notopterygii, Cortex Acanthopancis are ground into middle powder, Lignum Sappan, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Radix Clematidis are added 10 times of amounts of 75% ethanol soaked 1 hour, reflux, extract, 2 hours filters; Alcohol extract is reclaimed ethanol, and medicinal residues add 8 times in water amount heating extraction 2 hours, filter the water extract, alcohol extract mixes with the water extract and is concentrated into relative density 1.24, adding is assisted and is added agent peregal 0 and the above-mentioned medicated powder that makes in the concentrated solution; The gained mixed liquor stirs, and is mixed into soft material, and the back 80 ℃ of following dryings of granulating divide packing to get finished product granule.
Embodiment 2
Component and consumption: press medicine 100% (percentage by weight)
Lignum Sappan 12, Flos Carthami 6, Radix Salviae Miltiorrhizae 12, Olibanum 14, Rhizoma Et Radix Notopterygii 12, Radix Clematidis 17, Cortex Acanthopancis 16, Herba Lycopodii 6
Assist and add agent: peregal 05
Preparation method is with embodiment 1.
Claims (2)
1, a kind of activating blood circulation and unblocking obstruction bagged steeping drug, it is characterized in that drug component and amount ranges are: press medicine 100% (percentage by weight) Lignum Sappan 5～20, Flos Carthami 2～15, Radix Salviae Miltiorrhizae 10～20, Olibanum 5～10, Myrrha 5～10, Rhizoma Et Radix Notopterygii 5～15, Radix Clematidis 10～20, Herba Lycopodii 2～15, Cortex Acanthopancis 10～20, and add that skin penetrant peregal 0, its addition are arranged is 2～10.
2, a kind of preparation method of activating blood circulation and unblocking obstruction bagged steeping drug is characterized in that
A), it is standby Flos Carthami, Rhizoma Et Radix Notopterygii, Cortex Acanthopancis, Herba Lycopodii to be ground into medicated powder;
B), Lignum Sappan, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, Radix Clematidis are added soak with ethanol, reflux, extract, filter alcohol extract, add water and reflux, extract, in the medicinal residues, filter the water extract;
C), merge adding peregal 0 and the above-mentioned medicated powder that got after concentrating, granulation after fully mixing with the water extract behind the alcohol extract recovery ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99101999A CN1116892C (en) | 1999-04-05 | 1999-04-05 | Bagged blood circulation-activating and obstruction-dredging granule and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99101999A CN1116892C (en) | 1999-04-05 | 1999-04-05 | Bagged blood circulation-activating and obstruction-dredging granule and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1269217A true CN1269217A (en) | 2000-10-11 |
| CN1116892C CN1116892C (en) | 2003-08-06 |
Family
ID=5270719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99101999A Expired - Fee Related CN1116892C (en) | 1999-04-05 | 1999-04-05 | Bagged blood circulation-activating and obstruction-dredging granule and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1116892C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526172A (en) * | 2012-03-21 | 2012-07-04 | 河南省洛正制药厂 | Chinese medicinal bagged soaking agent for treating joint numbness pain and preparation method thereof |
| CN102552843A (en) * | 2011-12-12 | 2012-07-11 | 沃树峰 | Medicament composite for curing osteoarthropathy |
| CN105902502A (en) * | 2016-05-30 | 2016-08-31 | 中国科学院西北高原生物研究所 | Dracocephalum heterophyllum granules and preparation method thereof |
| CN107970418A (en) * | 2017-10-27 | 2018-05-01 | 滨州市中医医院 | A kind of activating blood circulation and unblocking obstruction dressing bag |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083718A (en) * | 1993-01-16 | 1994-03-16 | 金安 | Ginseng bone setting pill and powder |
-
1999
- 1999-04-05 CN CN99101999A patent/CN1116892C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552843A (en) * | 2011-12-12 | 2012-07-11 | 沃树峰 | Medicament composite for curing osteoarthropathy |
| CN102552843B (en) * | 2011-12-12 | 2014-06-04 | 沃树峰 | Medicament composite for curing osteoarthropathy |
| CN102526172A (en) * | 2012-03-21 | 2012-07-04 | 河南省洛正制药厂 | Chinese medicinal bagged soaking agent for treating joint numbness pain and preparation method thereof |
| CN105902502A (en) * | 2016-05-30 | 2016-08-31 | 中国科学院西北高原生物研究所 | Dracocephalum heterophyllum granules and preparation method thereof |
| CN105902502B (en) * | 2016-05-30 | 2018-07-17 | 中国科学院西北高原生物研究所 | A kind of dracocephalum heterophyllum particle electuary and preparation method thereof |
| CN107970418A (en) * | 2017-10-27 | 2018-05-01 | 滨州市中医医院 | A kind of activating blood circulation and unblocking obstruction dressing bag |
| CN107970418B (en) * | 2017-10-27 | 2021-01-12 | 滨州市中医医院 | Blood circulation activating and arthralgia dredging dressing bag |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1116892C (en) | 2003-08-06 |
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Owner name: XU BAOJUN; GUO YANXING; XIA HUALING; JINXUELING; Z Free format text: FORMER NAME OR ADDRESS: XU BAOJUN; GUO YANXING; CAO YAFEI; JINXUELING; XIA HUALING; ZHAO XINJIE; LIJUNHONG |
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| CP03 | Change of name, title or address |
Inventor after: Xu Baojun Inventor after: Guo Yanxing Inventor after: Xia Hualing Inventor after: Jin Xueling Inventor after: Zhao Xinjie Inventor after: Li Junhong Inventor after: Cao Yafei Inventor before: Xu Baojun Inventor before: Guo Yanxing Inventor before: Cao Yafei Inventor before: Jin Xueling Inventor before: Xia Hualing Inventor before: Zhao Xinjie Inventor before: Li Junhong |
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