CN1268698C - Inhibition of bacterial growth - Google Patents
Inhibition of bacterial growth Download PDFInfo
- Publication number
- CN1268698C CN1268698C CN 96180322 CN96180322A CN1268698C CN 1268698 C CN1268698 C CN 1268698C CN 96180322 CN96180322 CN 96180322 CN 96180322 A CN96180322 A CN 96180322A CN 1268698 C CN1268698 C CN 1268698C
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- biocides
- powder
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- particle
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Abstract
The present invention provides an inhibition method of bacterial growth on a coated substrate, which comprises the following steps: forming a dry powdery paint composition comprising biocide and coating the powdery paint composition on the substrate to form a coating layer. The biocide can still keep effective biocidal activity in the coating layer.
Description
Technical field
The present invention relates to inhibition, particularly relate to suppress bacterium in suprabasil growth to bacterial growth.
Summary of the invention
The method that the purpose of this invention is to provide a kind of bacteria growing inhibiting, it is that coating composition is coated in the substrate.
Another object of the present invention provides a kind of coating composition that is used for the inventive method.
In one aspect of the invention, a kind of method that bacterium grows in substrate that suppresses is provided, this method comprises that formation comprises the dry powder coating composition of biocides, this powder paint compositions is coated in forms coating in the substrate, the biocidal active that still can remain valid at biocides described in this coating.
Preferably, use static or triboelectricity spraying method that described composition is coated in the substrate.
In another aspect of this invention, provided the coating composition that is used for aforesaid method, said composition comprises the biocides of 0.1-20 weight %, dry and be applicable to by static or triboelectricity spraying and be applied to suprabasil powder basically.Preferably, the consumption of biocides is 0.1-10 weight %.
The present invention also provides with the inventive method manufacturing and/or comprises the coated article of coating of the present invention.
In one embodiment, the invention provides the powdered mixture of the powder of the matrix that comprises the biocides powder and form coating composition.
In this embodiment, biocides has the physical property identical with the matrix powder usually to be easy to coating.
In addition, biocides can mix in the powder that forms coating matrix.No matter use any method, wish that all biocides is blended in the powder composition equably.In fact, this can for example realize in the process of composition that makes powder.Therefore, in a preferred embodiment, final powder has the particle that respectively comprises biocides, matrix powder and any other added ingredients.Because each particle comprises biocides, thus it can be evenly distributed in the coating composition, and can be singly from coming out.For example, promptly add biocides, so just can be made into above-mentioned powder in the initial mixing stage of the component for desired matrix powder to be transformed.In typical powder manufacturing processed, the precursor of desired powder as resin and stiffening agent thereof, mixes with any other additive, and heating is extruded into sheet then, then with this flap granulation, and is ground to desirable powder size.Can realize extraordinary component mixing thus, and all components are present in each particle of final powder with desirable ratio all.
Coating composition preferably includes pigment and forms the powder of the matrix of coating composition, therefore comprises suitable pigment in this embodiment.
Coating composition is preferably formed the drying composite into powdery components.
Can select to have the biocides of resisting gram-positive and/or Gram-negative bacteria, algae, filamentous fungus or yeast activity, and this biocides can be to have the anti-bioactive conventional biocides of multiple above-mentioned classification.
Can suitably use many biocidess in the present invention, and those of ordinary skills can confirm easily whether any concrete biocides still keeps enough biocidal active in the special requirement of this coating by routine test.Necessary standard is to provide biocides with suitable powder type, and this biocides can be survived in coating process.
Find that specially suitable biocides kind comprises:
The Triclosan class, as 2,4,4
1-three chloro-2
1-dihydroxy diphenyl ether,
The methyl ureas, as 3-(3, the 4-dichlorophenyl)-1, the 1-dimethyl urea, and
The imidazoles amino formate.
The matrix of coating composition can be used any suitable material, and this material can be made into powder type, and coated coating is produced desirable performance such as weather resistance, and can be combined on the substrate surface satisfactorily.
The article that are coated with application layer are preferably metal, but the present invention is not limited to this, also can comprise for example home appliances (so-called white, brown article), family expenses and industrial working-surface, and building and other engineering product are as hand-rail, door handle and backplate; Garden furniture etc.Typical substrate for example can be iron metal, galvanized steel, aluminium etc.Therefore these article needing in the environment of health can be used for.
As mentioned above, electrostatic spraying that powder paint compositions of the present invention can be by craft or automatization or triboelectricity spray and apply.
The specially suitable material that is used to form the matrix of coating composition comprises epoxy, polyester and epoxy-polyester, and is powder type and painted in advance, to produce various desirable finishinges---glazing, delustring and burr.But the present invention is not limited only to this, and can use other polymer powder materials, as thermoplastic material, and for example nylon, acrylic acid or the like, polyethylene, polypropylene and EVA.
The matrix powder has the proportion of 1.2-1.9 usually, and 100% less than 100 microns in the particle diameter, and 40-60% is greater than 34 microns.Their bake out temperature for example is at least 120 ℃, and as 140-210 ℃, this depends on the physical property of used concrete material fully.
When using with independent powder, biocides preferably has and the similar size distribution of matrix powder.
The amount that is incorporated in the biocides in the powder composition changes according to the intensity and the character of end-use and concrete biocides.Therefore, appropriate vol can be according to the known consumption of concrete biocides and easily is determined.For example, the usage quantity of biocides can be at most most 20 weight % of total powder composition.Usually useful ratio is the 0.1-10 weight %, particularly 2-6 weight % of total powder composition.
In powder composition, also can comprise other component, as liquid agent, dispersion agent, sanitas.
According to used concrete biocides, the powdered mixture that is mixed with the biocides powder has the good preservation life-span, still, also can be before use soon time mix.
Be understandable that in the coating field substrate must be cleaned completely, and can be undertaken by ordinary method as shot peening and/or chemically treated cleaning before the coating powder mixture.
Embodiment
The specific embodiments that present invention will be further described in following examples.
Embodiment 1
The powdered material that mixes following ratio, preparation coloring powder coating composition.
Weight part
Biocides 0-6
Matrix powder 100-94
Biocides is to be called 2,4,4 of IRGASAN DP 300 by the commodity that CIBA GEIGY provides
1-three chloro-2
1Dihydroxy diphenyl ether.The matrix powder is special-purpose polyester powder.
On the metallic surface, handle through the shot-peening degrease in advance on this surface, and several sample strip are provided thus with the powdered mixture electrostatic spraying, and this sample strip only has coating on a surface.
Listed as following table 1, the lawn plate of the 5 kind different bacterium of preparation in the tryptone soy agar is placed sample strip at the center of each plate, and its coated side down.The lawn plate at 37 ℃ of following incubation 24-48 hours, and is observed the inhibition zone.
The results are shown in following table 1, wherein each sample strip repeats 3 times.
Table 1
| Biological | Biocides percentage ratio | |||
| 0 | 2 | 4 | 6 | |
| E.Coli | --- | +-- | +-- | +-- |
| P.aeruginosa | --- | +-- | +-- | +-- |
| S.typhimurium | --- | --- | --- | --- |
| S.aureus | +-- | +-- | +-- | +-- |
| S.faecalis | --- | --- | +-- | --- |
+--=restraining effect arranged
---=unrestraint effect
Embodiment 2
The powdered material that mixes following ratio, the preparation powder paint compositions.
Weight part
Biocides 6
Matrix powder 94
Biocides such as embodiment 1.
The matrix powder is by H B Fuller Coatings Limited (Birmingham, the polyester that is numbered OMEGA PC P6/035 that England) provides.
Under 200 ℃, powdered mixture was sprayed on last 5 minute of microslide that width is about 25mm.
As shown in table 2 below, be prepared as follows the lawn plate of 8 kinds of different bacterium.The slide applicator surface that has applied up is placed in the Petri culture dish, comprises agar nutritive ingredient in this culture dish as embodiment 1.With nutritive ingredient film coverage test slide.The coating of each bacterium is in line passes across culture dish, and continues to cross the test slide.As mentioned above, three samples of various situations (at every turn) test.
Table 2 has been listed restraining effect degree (DOI) and restraining effect zone (ZOI), and the latter's unit is mm.DOI represents each bacterium line width of disappearing, and ZOI represents the biology line length of crossing slide and disappearing in its both sides.
Table 2
| The 1st time | The 2nd time | |||
| Biological | DOI | ZOI(mm) | DOI | ZOI(mm) |
| Staphylococcus aureas (Oxford) | Fully | 55 | Fully | 55 |
| Staphylococcus aureas (Resistant) | Fully | 50 | Fully | 45 |
| Enterococcus faecalis | 50％ | 25 | 50％ | 25 |
| Escherichia-coli | Fully | 30 | Fully | 30 |
| Salmonella typhimurium | Fully | 30 | Fully | 30 |
| Pseudomonas aeruginosa | Do not have | - | Do not have | - |
| Corynebacterium diptheria (non-toxicity) | 50％ | 25 | 50％ | 25 |
| Bacillus subtilis | Fully | 35 | Fully | 35 |
Embodiment 3
Repeat embodiment 2, but be to use 6 kinds of listed biologies of following table 3, the working concentration of biocides is 0-20 weight %.Redeterminate the restraining effect zone, be listed in the table 3.
Table 3
| Biological | Biocide concentration (%w/w) | ||||
| 0 | 6 | 10 | 15 | 20 | |
| E.coli | 0 | 31 | 43.7 | 57.3 | 49.3 |
| Strep faecalis | 0 | 25 | 25 | 25 | 26.7 |
| S.aureas(Oxford) | 42 | 52.3 | 76.7 | 100 | 100 |
| S.aureas(Resistant) | 42.3 | 53.7 | 100 | 100 | 100 |
| P.aeruginosa | 0 | 0 | 0 | 0 | 0 |
| B.subtilis | 0 | 26 | 32 | 41.6 | 43 |
| Salmonella typhimurium | 0 | 25.3 | 32 | 39 | 43 |
Be understandable that the present invention is not limited in above-mentioned specific embodiments.For example, other is used for the appropriate technology of applying coating on metal base is so-called plastics coating technology, wherein, with the substrate preheating, is immersed in the powder bed then.This technology also constitutes a part of the present invention.
Claims (24)
1, a kind of biocides is evenly distributed in method in the powder paint compositions basically, described method comprises:
The precursor and the biocides powder of polymer powder are mixed together, and heat this mixture;
Described hot mixt is extruded into sheet;
Make described flap granulation; Then
Grind described particle to powder.
2, the method for claim 1, it comprises the step that further powder is ground to the particle diameter that is suitable for electrostatic spraying.
3, the method for claim 1, the blending ratio of wherein said biocides and described polymer precursor account for the 0.1-20 weight % of total powder composition for this biocides.
4, method as claimed in claim 3, wherein, the amount of described biocides in total powder composition is 2-6 weight %.
5, as the described method of one of claim 1-4, wherein, described biocides is the Triclosan class.
6, method as claimed in claim 5, wherein, described biocides is 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether.
7, as the described method of one of claim 1-4, wherein, described biocides is the methyl ureas.
8, method as claimed in claim 7, wherein, described biocides is 3-(3, the 4-dichlorophenyl)-1, the 1-dimethyl urea.
9, as the described method of one of claim 1-4, wherein, described biocides is the imidazoles amino formate.
10, as the described method of one of claim 1-4, wherein, the proportion of described polymer powder is that 1.2-1.9, particle diameter are less than 100 microns.
11, as the described method of one of claim 1-4, wherein, described polymer powder comprises polyester or acrylic acid or the like powder.
12, as the described method of one of claim 1-4, wherein, described polymer powder comprises the epoxy polyester powder.
13, as the described method of one of claim 1-4, wherein, described polymer powder comprises thermoplastic powder.
14, method as claimed in claim 13, wherein, described polymer powder comprises nylon, polypropylene, polyethylene or ethene-vinyl acetate copolymer.
15, a kind of dry powder coating composition, said composition comprise the particle that is polymer powder separately and all comprises biocides, and wherein, described biocides accounts for the 0.1-20% of said composition weight, and is evenly distributed in substantially in the described composition.
16, a kind of dry powder coating composition, said composition comprises the polymer powder materials that all comprises biocides separately, wherein, described biocides accounts for the 0.1-20% of said composition weight, and is trichlorine hydroxy diphenyl ether, methyl urea or imidazoles carbamate.
17, powder paint compositions as claimed in claim 16, wherein, described polymer powder materials is polyester or acrylic polymers.
18, powder paint compositions as claimed in claim 16, wherein, described polymer powder materials is an epoxy polyester.
19, a kind of dry powder coating composition, said composition comprises the thermoplastic material particle of the biocides that all comprises 0.1-20 weight % separately, and described biocides is trichlorine hydroxy diphenyl ether, methyl urea or imidazoles carbamate.
20, powder paint compositions as claimed in claim 19, wherein, described thermoplastic material is nylon, polypropylene, polyethylene or ethene-vinyl acetate copolymer.
21, a kind ofly provide the method for bio-killing activity to being coated in suprabasil coating, it comprises by electrostatic spraying apply a kind of Biocidal dry powder coating composition in described substrate, said composition comprises the particle that is polymer powder separately and all comprises biocides, wherein said biocides accounts for the 0.1-20% of said composition weight, and is evenly distributed in substantially in the described composition; Oven dry then.
22, a kind ofly provide the method for bio-killing activity to being coated in suprabasil coating, it comprises by electrostatic spraying apply a kind of Biocidal dry powder coating composition in described substrate, said composition comprises the particle that is polymer powder separately and all comprises biocides, wherein said biocides accounts for the 0.1-20% of said composition weight, and is trichlorine hydroxy diphenyl ether, methyl urea or imidazoles carbamate.
23, a kind ofly provide the method for bio-killing activity to being coated in suprabasil coating, it comprises by electrostatic spraying apply a kind of Biocidal dry powder coating composition in described substrate, said composition comprises the thermoplastic material particle of the biocides that all comprises 0.1-20 weight % separately, and described biocides is trichlorine hydroxy diphenyl ether, methyl urea or imidazoles carbamate.
24; a kind of article that have the Biocidal coating on it; described Biocidal coating comprises cure polymer matrix; and wherein contain the particle of biocides; described biocides particle is evenly distributed in the described Biocidal coating substantially; described Biocidal coating is by obtaining with the powder coating Biocidal composition and the subsequent drying of electrostatic spraying at article coating substantially dry; the powder coating Biocidal composition of described substantially dry comprises the thermoplastic material particle of the biocides that all comprises 0.1%-20 weight % separately, and described biocides is a trichlorine hydroxy diphenyl ether; the methyl urea; perhaps imidazoles carbamate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96180322 CN1268698C (en) | 1996-06-05 | 1996-06-05 | Inhibition of bacterial growth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96180322 CN1268698C (en) | 1996-06-05 | 1996-06-05 | Inhibition of bacterial growth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1222177A CN1222177A (en) | 1999-07-07 |
| CN1268698C true CN1268698C (en) | 2006-08-09 |
Family
ID=5127800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96180322 Expired - Fee Related CN1268698C (en) | 1996-06-05 | 1996-06-05 | Inhibition of bacterial growth |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1268698C (en) |
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1996
- 1996-06-05 CN CN 96180322 patent/CN1268698C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1222177A (en) | 1999-07-07 |
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Granted publication date: 20060809 Termination date: 20110605 |