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CN1251670C - Consumable container - Google Patents

Consumable container Download PDF

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Publication number
CN1251670C
CN1251670C CNB018159184A CN01815918A CN1251670C CN 1251670 C CN1251670 C CN 1251670C CN B018159184 A CNB018159184 A CN B018159184A CN 01815918 A CN01815918 A CN 01815918A CN 1251670 C CN1251670 C CN 1251670C
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CN
China
Prior art keywords
container
oral cavity
chambers
contents
animal body
Prior art date
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Expired - Fee Related
Application number
CNB018159184A
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Chinese (zh)
Other versions
CN1477954A (en
Inventor
伦纳德·L·布朗
埃德温·C·布朗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Etablissement de Machines Industrielles
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Etablissement de Machines Industrielles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB0020148A external-priority patent/GB0020148D0/en
Priority claimed from GB0022624A external-priority patent/GB0022624D0/en
Application filed by Etablissement de Machines Industrielles filed Critical Etablissement de Machines Industrielles
Publication of CN1477954A publication Critical patent/CN1477954A/en
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Publication of CN1251670C publication Critical patent/CN1251670C/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/13Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1303Paper containing [e.g., paperboard, cardboard, fiberboard, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Packages (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Wrappers (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

本发明公开了一种用于在消耗者口腔内快速释放其内含物的可消耗容器。该可消耗容器包括限定封闭空腔的外壳和在外壳内的封闭的内容器,其中外壳包括在放入人体或动物体口腔中时易于破碎的紧密的纤维状物质。

Figure 01815918

The present invention discloses a consumable container for rapid release of its contents within the oral cavity of a consumer. The consumable container includes an outer shell defining an enclosed cavity and a closed inner container within the outer shell, wherein the outer shell includes a compact, fibrous mass that breaks readily when placed in the oral cavity of a human or animal body.

Figure 01815918

Description

Consumable container
Technical field
The present invention relates to a kind of consumable container (consumable container), particularly act on the container of human body or animal by the oral cavity mode, the capillary tube of its inclusions by the oral cavity absorbs in the blood flow of consumer into.
Background technology
Capillary tube by the oral cavity absorbs into and is better than absorbing by the intestinal inner membrance in the blood flow.For example, can be quicker and more efficient by the capillary tube absorption in oral cavity.In addition, absorb in the oral cavity can so that be easy to by gastric juice damage or may in addition destroyed safety of medicine be sent in the blood flow.
Related to before material arrives blood flow absorbed material by each organ of digestive system by intestinal absorption.The major part of active component is renderd a service and may be lost in this process in the material.On the other hand, provide more direct passage, helped to keep the effectiveness of active component to blood flow by buccal absorption.
Medicines etc. must make medicine be transformed into the form of alkali chemical compound (salt) in the course of processing by the absorption of intestinal usually.The compressible one-tenth pill of salt based compound or keep its powder type and incapsulate.Consumer ingestion of pills or capsule, medicine is transformed into its original form by digestive system.The remarkable shortcoming of this method is usually to be transformed into the salt based compound and to produce drug effect from the salt based compound is transformed into the process of medicine from medicine to reduce.The consequence that drug effect reduces may be the increase of drug level or quantity.The increase of concentration or quantity may cause the damage that the digestive system by consumer causes or even may be to damage to increase.
For a long time, medicine is by the oral cavity means that absorb as those diseases that need alleviate fast of treatment capillaceous.For example, since century, angina pectoris is to be placed on the Sublingual by the capsule that will contain nitro-glycerol to treat more than one.The capsule that contains nitro-glycerol breaks to discharge its inclusions with tooth.Usually use a kind of gelatin capsules of single component.
People have proposed complicated more capsule structure.Usually, this capsule structure is designed to be swallowed by consumer.A kind of such gelatin capsules is described in GB 2283899.The capsule of GB 2283899 has the release that is used to control and delay unpalatable medicine, preferably discharges in intestinal.
The capsule that contains nitro-glycerol of above-mentioned single component and more complicated capsule (example is seen GB2283899) need time and active force to come to discharge its inclusions on the position of consumer in the oral cavity.Far and away, just it was gulped down before draw or chew on this capsule, may would rather containing thing release within it with person's unwilling spended time of possibility and active force.
The inventor recognizes that people exist be more prone to discharge the demand of the consumable container of its inclusions in the consumer oral cavity.
Summary of the invention
According to a first aspect of the invention; provide a kind of by human body or animal body consumable container; comprise by having the closely fibrous material of abundant intensity and constitute and limit the shell of sealed hollow with the opposing stores/processes; liquid-tight inner pressurd vessel with sealing in the cavity; this inner pressurd vessel is mechanically fragile and be subjected to the protection of outer container; this container contains the inclusions of liquid property with in the blood flow that absorbs human body or animal body; this container comprises indigestible composition; closely the character of fibrous material be with container when putting into human body or animal body oral cavity; fibrous material is broken in saliva closely; the character of the inner pressurd vessel of sealing makes and is easy to fragmentation in the oral cavity of human body or animal body, thereby discharges the content that will be absorbed in human body or the animal body oral cavity.
Fibrous material is made of the fiber of tight compression closely, and the major part of these fibers is surperficial consistent with shell.Therefore, by being approximately perpendicular to externally applied forces on the direction of case surface, shell is easier to fragmentation.Therefore, shell has sufficient rigidity and intensity is prepared against storage and processing, but not too can resist the power that is applied on the capsule when putting into the oral cavity.
Fibrous material can comprise paper closely, as rice or corn paper.Another kind of scheme or additionally, fibrous material can comprise the mixture of the Radix Acaciae senegalis and the wood fiber closely.
Shell can be by liquid softening (at least partially).More particularly, water can cause shell (at least partially) to decompose.Saliva in the consumer oral cavity can cause the decomposition according to the shell of the consumable container of these embodiment.
Inner pressurd vessel can be liquid-tight basically.Consumable container according to these embodiment is suitable for encapsulating the material that contains liquid or moisture.
The time degraded in being exposed to air of many materials.Therefore, according to some embodiment, consumable container can provide sufficient gas-tight seal for its inclusions.More particularly, consumable container can be not see through oxidizing gas basically.Gas-tight seal or impermeable barrier can form by inner pressurd vessel.
According to specific embodiment, consumable container can be opaque substantially.Therefore, the inclusions of consumable container can be protected and not be subjected to the illeffects of sunlight.
Inner pressurd vessel can comprise the ester of the monohydric alcohol of higher homologue.More particularly, inner pressurd vessel can comprise Cera Flava.Consumable container according to these embodiment has above-mentioned desirable properties, that is, the material that gas-tight seal fully is provided and prevents to contain liquid or moisture influences the globality of shell.In addition, the ester of the monohydric alcohol of higher homologue (as, Cera Flava) often experience plastic deformation when putting into the oral cavity, thus discharge inclusions.Plastic deformation can by salivate, moving of tongue cause with similar chewing.According to specific embodiment, plastic deformation may (for example) generation within putting into the oral cavity after about 0.5 to 60 second.
Consumable container can comprise indigestible basically composition.The existence of indigestible composition can hinder consumer and swallows this container in the consumable container.
More particularly, inner pressurd vessel can comprise one or more in plastic material, hard paraffin and the bakelite.
In the embodiment according to epimere, inner pressurd vessel can be provided with wax coating, as the Cera Flava coating.This wax coating can form gastight and sealing waterproof around inner pressurd vessel.
Another kind of scheme or additionally, indigestible basically composition can be fibrous material, as raw cotton.Raw cotton can (for example) be used to absorb the inclusions of consumable container.
Reached after the purpose of the present invention, the inventor has recognized that the present invention has a more wide in range application than above-described.Basically the existence of indigestible composition in consumable container can impel consumer that consumable container is remained in his oral cavity basically, and do not take the easy or rapid degree of container fragmentation into account.
Therefore, second aspect present invention provides a kind of consumable container that comprises shell that limits enclosed cavity and the inner pressurd vessel that seals in the enclosure, and wherein consumable container comprises the composition that human body is indigestible.
According to this aspect of the present invention, indigestible composition may hinder consumer and swallow consumable container.
More particularly, inner pressurd vessel can comprise one or more in plastic material, hard paraffin and the bakelite.Another kind of scheme or additionally, the indigestible composition of human body can be fibrous material, as raw cotton.
The consumable container configuration aspects beguine that is present in of indigestible composition provides bigger degree of freedom according to the consumable container of first aspect present invention.Easy and the rapid fragmentation of shell is less-than-ideal character.Therefore, except the parts of the consumable container of above-mentioned first aspect, outer container can comprise frumentum, as wheat flour or the starch from obtaining as Rhizoma Solani tuber osi or rice.
Inner pressurd vessel of the present invention can be a kind of form wherein.According to a kind of such form, the outer surface region of inner pressurd vessel can coextend with the inner surface area of shell body, and inner pressurd vessel serves as a contrast to shell body thus.More particularly, inner pressurd vessel can be for being formed on the barrier film on the shell body inboard.
According to the another kind of form of inner pressurd vessel, the exterior surface area of inner pressurd vessel can be basically less than the inner surface area of shell body.Another kind of scheme or additionally, inner pressurd vessel can be arranged on the bag of shell body inboard for loose ground.
Inner pressurd vessel can comprise a plurality of chambers.Another kind of scheme or additionally, a plurality of inner pressurd vessels can be contained within the shell body, and each inner pressurd vessel can have a chamber.Different materials can be contained in each of a plurality of chambers.More particularly, when consuming the consumable container that constitutes according to these embodiment, the configuration of shell inner cavity chamber can be such, makes the inclusions of at least two chambers discharge simultaneously, perhaps makes the inclusions of a plurality of chambers discharge with predefined procedure.Time cycle from chamber release inclusions after putting into the oral cavity can be controlled by set predetermined solubility for inner pressurd vessel.
According to the present invention, any in liquid, pastel or solid such as pill or the powder or multiplely can place inner pressurd vessel.Such material can be in medicine, food, cosmetics or the pan work one or more.This material can be mixed to guarantee its stability with media (vector).
According to most preferred embodiment, this material can comprise royal jelly.Another kind of scheme or additionally, this material can comprise Mel.
Description of drawings
The specific embodiment of the present invention will be elaborated with reference to accompanying drawing by example, in the accompanying drawing:
Fig. 1 shows the consumable container as one embodiment of the present invention; With
Fig. 2 is the method flow diagram of the consumable container of shop drawings 1.
The specific embodiment
As shown in Figure 1, consumable container 100 according to the present invention comprises: the shell 110 that defines sealed hollow; With inner pressurd vessel 120 as membranous sealing on the inner surface of outer cover.Inner pressurd vessel has three chambers, and they are provided with two spacers by the inboard at inner pressurd vessel and form.A kind of material for example, contains the Mel of royal jelly, can place a chamber; And another kind of material, for example, Radix Ginseng, pollen or Ginko Biloba can place another chamber.Loose fibres ball 140 (indigestible composition constitutes) places central bore.Certainly, fibrous nodules can place chamber any one or a plurality of.
Shell 110 is by breaking when putting into the consumer oral cavity and broken fibrous material closely such as rice or corn paper are made.Consumer oral cavity (for example, by tongue or cheek) applied pressure can cause outer casing rupture.Saliva is decomposed the fragmentation that helps container by making shell.
Inner pressurd vessel 120 is made by Cera Flava, and for the inclusions of container provides hermetic seal, and the inclusions that prevents to contain liquid or moisture influences the integrity of shell.When putting into the oral cavity, the temperature of consumable container rises to body temperature, causes inner pressurd vessel softening and broken, thereby discharges inclusions.
Loose fibres ball 140 is made by indigestible material such as raw cotton.After the fragmentation, loose fibres ball 140 hinders swallows residue with the person in usefulness person oral cavity for shell and inner pressurd vessel.The loose fibres ball can (for example) place under the tongue, and the inclusions band is near to the trunk that is positioned at this place.
Consumable container 100 is dish-shaped, is circular when the top is seen, and is elongated when seeing from the side.The diameter of consumable container is usually in 10mm to 100mm scope, highly usually in 3mm to 20mm scope.
The method 200 of the consumable container of shop drawings 1 is described with reference to Fig. 2.
The fibrous material of being made by rice or corn etc. is configured as pastel and forms the thick thin slice of about 0.5mm to 1mm by pressure roller.Thin slice is cut into two of identical size.
One of them thin slice is layered on the open mold, and this open mold has the cavity of specific quantity, and each cavity is used to form an one consumable container.Mould cavity is shaped to have spacer shown in Figure 1 130.Vacuum is applied to the downside of thin slice, makes the thin slice lining on cavity.Heating mould makes it cooling 210 fast then with drying slice.
Heat second not molded thin slice and make it cooling fast and form upward thin slice 220.
One or more layers impermeable material (as Cera Flava or meagre plastic material) is sprayed on the upper surface of molded thin slice and on the surface of last thin slice, till the desired thickness that deposits to impermeable material.Make impermeable material drying 230 then.
Under the situation that mould cavity does not have to be shaped and to form spacer, spacer 130 can form separately and place on the upper surface of molded thin slice.Spacer can be formed by the fibrous material identical with molded thin slice.
Cavity in the molded thin slice has been full of desired material, for example, contains the Mel of royal jelly, and the loose fibres ball is put into central cavity 240.
Last thin slice is placed on molded thin slice top, and impermeable material is towards cavity, and the content of cavity is encapsulated between thin slice and the molded thin slice.Last thin slice and molded thin slice press together, and seal as forming around each cavity with ultrasonic bonding or hot rifle 250 with proper implements.
The last thin slice of sealing and molded thin slice form one consumable container 260 around each cavity cutting.
Can recognize that consumable container and the miscellaneous part described with reference to above-mentioned embodiment can be combined in other embodiments of the present invention.

Claims (25)

1.一种由人体或动物体可消耗容器,包括由强度足以承受存储/处理的紧密的纤维状物质构成并限定封闭的空腔的外壳,和空腔内的封闭的不透液体的内容器,所述内容器在机械上脆弱并受到外容器的保护,所述内容器含有液体性质的内含物以吸收进人体或动物体的血流中,该容器包括不可消化的成分,紧密的纤维状物质的性质是在将容器放入人体或动物体口腔中时,紧密的纤维状物质在唾液中破碎,封闭的内容器的性质使得易于在人体或动物体的口腔中破碎,从而释放将要吸收入人体或动物体口腔中的内容物。1. A consumable container for the human or animal body comprising an outer shell of compact fibrous material of sufficient strength to withstand storage/handling and defining a closed cavity, and a closed liquid-tight inner container within the cavity , said inner receptacle is mechanically fragile and protected by an outer receptacle, said inner receptacle contains contents of a liquid nature for absorption into the bloodstream of the human or animal body, said receptacle comprises indigestible components, dense fibers The nature of the shaped substance is that when the container is placed in the oral cavity of the human or animal body, the compact fibrous substance breaks up in saliva, and the nature of the closed inner container makes it easy to break in the oral cavity of the human or animal body, thereby releasing the to-be-absorbed Contents that enter the oral cavity of a human or animal body. 2.如权利要求1所述的容器,其中,紧密的纤维状物质是纸。2. A container as claimed in claim 1, wherein the compact fibrous substance is paper. 3.如权利要求2所述的容器,其中,所述纸是大米或玉米纸。3. The container of claim 2, wherein the paper is rice or corn paper. 4.如权利要求1或2所述的容器,其中,紧密的纤维状物质包括阿拉伯树胶和木纤维的混合物。4. A container as claimed in claim 1 or 2, wherein the compact fibrous mass comprises a mixture of gum arabic and wood fibres. 5.如权利要求1所述的容器,其中,该容器是不透氧化气体的。5. The container of claim 1, wherein the container is impermeable to oxidizing gases. 6.如权利要求1至3中任一项所述的容器,其中,所述容器是不透明的。6. A container as claimed in any one of claims 1 to 3, wherein the container is opaque. 7.如权利要求1至3中任一项所述的容器,其中,内容器包括高级同系物的一元醇的酯。7. A container as claimed in any one of claims 1 to 3, wherein the inner container comprises an ester of a monohydric alcohol of a higher homologue. 8.如权利要求7所述的容器,其中,内容器包括蜂蜡。8. The container of claim 7, wherein the inner container comprises beeswax. 9.如权利要求1所述的容器,其中,内容器包括塑料材料、固体石蜡和酚醛塑料中的一种或多种。9. The container of claim 1, wherein the inner container comprises one or more of a plastic material, paraffin wax, and Bakelite. 10.如权利要求1至3中任一项所述的容器,其中,内容器设置有蜡涂层。10. A container as claimed in any one of claims 1 to 3, wherein the inner container is provided with a wax coating. 11.如权利要求1所述的容器,其中,不可消化的成分是纤维状材料。11. The container of claim 1, wherein the non-digestible component is a fibrous material. 12.如权利要求11所述的容器,其中,纤维状材料是原棉。12. A container as claimed in claim 11, wherein the fibrous material is raw cotton. 13.如权利要求1至3中任一项所述的容器,其中,内容器的外表面区域和外壳体的内表面区域共同扩张,由此内容器给外壳体作衬。13. A container as claimed in any one of claims 1 to 3, wherein the outer surface area of the inner container and the inner surface area of the outer shell are coextensive, whereby the inner container lines the outer shell. 14.如权利要求13所述的容器,其中,内容器是形成在外壳体内侧上的隔膜。14. The container of claim 13, wherein the inner container is a septum formed on the inside of the outer casing. 15.如权利要求1至3中任一项所述的容器,其中,内容器的外表面面积小于外壳体的内表面面积。15. A container as claimed in any one of claims 1 to 3, wherein the outer surface area of the inner container is smaller than the inner surface area of the outer shell. 16.如权利要求1至3中任一项所述的容器,其中,内容器是松松地设置在外壳体内部的袋囊。16. A container as claimed in any one of claims 1 to 3, wherein the inner container is a pouch loosely disposed inside the outer casing. 17.如权利要求1所述的容器,其中,内容器包括多个腔室。17. The container of claim 1, wherein the inner container includes a plurality of chambers. 18.如权利要求1所述的容器,其中,多个内容器容纳在外壳体之内,而且每个内容器限定一个腔室。18. The container of claim 1, wherein a plurality of inner containers are received within the outer housing, and each inner container defines a chamber. 19.如权利要求17或18所述的容器,其中,不同的物质容纳在每个腔室中。19. A container as claimed in claim 17 or 18, wherein a different substance is contained in each chamber. 20.如权利要求17或18所述的容器,其中,在消耗该容器时,腔室在外壳内的配置使得至少两个腔室的内含物同时释放。20. A container as claimed in claim 17 or 18, wherein, upon consumption of the container, the chambers are arranged within the housing such that the contents of at least two chambers are released simultaneously. 21.如权利要求17或18所述的容器,其中,在消耗可消耗容器时,腔室在外壳内的配置使得多个腔室的内含物以预定顺序释放。21. A container as claimed in claim 17 or 18, wherein upon consumption of the consumable container, the arrangement of the chambers within the housing is such that the contents of the plurality of chambers are released in a predetermined sequence. 22.如权利要求1所述的容器,其中,内含物包括药物、食品、化妆品或糖果制品中的一种或多种。22. The container of claim 1, wherein the contents include one or more of pharmaceutical, food, cosmetic or confectionery products. 23.如权利要求22所述的容器,其中,内含物包括王浆和蜂蜜中的一种或二者。23. The container of claim 22, wherein the contents include one or both of royal jelly and honey. 24.一种包括如权利要求1所述的容器的药物或食品。24. A medicine or food comprising the container of claim 1. 25.一种包括如权利要求1所述的容器的糖果。25. A confectionery comprising the container of claim 1.
CNB018159184A 2000-08-17 2001-07-20 Consumable container Expired - Fee Related CN1251670C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0020148A GB0020148D0 (en) 2000-08-17 2000-08-17 Consumable container
GB0020148.3 2000-08-17
GB0022624A GB0022624D0 (en) 2000-09-15 2000-09-15 Consumable container
GB0022624.1 2000-09-15

Publications (2)

Publication Number Publication Date
CN1477954A CN1477954A (en) 2004-02-25
CN1251670C true CN1251670C (en) 2006-04-19

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US (1) US20040022972A1 (en)
EP (1) EP1309318A1 (en)
JP (1) JP2004513080A (en)
CN (1) CN1251670C (en)
AU (1) AU2001270891A1 (en)
WO (1) WO2002015887A1 (en)

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EP1309318A1 (en) 2003-05-14
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