CN1220517C - Medication for curing disease of stomach intestine - Google Patents

Abstract

The present invention relates to a Chinese and western medicine combination medicine for treating gastrointestinal disease, particularly to a pill for invigorating the stomach and caring the intestines, which is prepared from dried ginger, parched hawthorn fruit, stir-baked rhizoma dioscoreae, licorice root, coptis, aucklandia root, magnolia bark, coloured malt, chicken's gizzard membrane, cuttle bone, salep, bupleurum root, colloidal bismmth pectin, oryzanol and propantheline according to a certain proportion by weight. The medicine of the present invention can thoroughly eradicate helicobacter pylori, inhibit gastric acid secretion, protect the gastrointestinal mucous membrane and regulate patient's emotional reaction and viscera functions so as to achieve the satisfied effects of treating both manifestation and root cause of disease and preventing recurrence.

Description

A kind of medicine for the treatment of gastrointestinal disease

Technical field

The present invention is a kind of medicine of collaborative treatment of Chinese and western medicines gastrointestinal disease.

Background technology

At present, stomach and dudenal disease are human commonly encountered diseases, frequently-occurring diseases, are worldwide distribution, estimate to have approximately 10% population to suffer from this disease in life.Mainly comprise acute or chronic gastritis, functional dyspepsia, duodenitis, peptic ulcer etc., main performance has epigastrium flatulence discomfort, burning sensation or pain, anorexia or early full, feel sick, vomiting, belch, acid regurgitation and noisy sense and digestive tract hemorrhage etc.Therapeutic Principle, method are varied, at present, on the market medicine of treatment gastrointestinal disease have that WEIDE is peaceful, bismuth potassium citrate, gavirin tablet, gastrointestinal peace sheet etc., these medicines be mostly simple anti-inflammation or simple by gastric acid inhibitory, in and gastric acid control some symptoms of gastroenteropathy, in case drug withdrawal, relapse rate is high.The ulcer frequent recurrence once was one of main feature of peptic ulcer natural history, and with the ulcer after healing after the conventional gastric acid inhibitory secretion Drug therapy, the year relapse rate of ulcer is 50%-70% after the drug withdrawal.

Summary of the invention

Therefore, still there is demand in people for the medicine of the treatment gastrointestinal disease of better efficacy.Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The inventor, proves and adopts the health intestinal pill for curing that is good for the stomach according to a large amount of clinical practices through research for many years, the cure rate height, and relapse rate is low.

The medicine that the purpose of this invention is to provide the low treatment gastrointestinal disease of a kind of cure rate height, relapse rate of better efficacy.

Another object of the present invention provides the preparation method of this medicine.

The consumption of drug component of the present invention is repeatedly studied with the clinical trial summary through the inventor and is drawn, and each amounts of components is for all to have better curative effect in the following weight parts scope:

Rhizoma Zingiberis 18-22 part, Fructus Crataegi (parched to brown) 8-12 part, Rhizoma dioscoreae (parched) 18-22 part, Radix Glycyrrhizae 18-22 part, Rhizoma Coptidis 28-32 part, above Chinese medicine of the five flavours decoction pieces decocting soup; Radix Aucklandiae 3-6 part, Cortex Magnoliae Officinalis (Cortex Magnoliae Officinalis) 3-6 part, Fructus Hordei Germinatus (parched) 8-12 part, Endothelium Corneum Gigeriae Galli 3-6 part, Os Sepiae 8-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6 part, Radix Bupleuri 3-6 part, colloidal bismmth pectin (tieing up quick) 8-12 part, oryzanol 1-2 part, Propantheline (probanthine) 8-12 part.Said medicine all can directly have been bought in pharmacy.

Be preferably: 20 parts of Rhizoma Zingiberiss, 10 parts of Fructus Crataegi (parched to brown)s, 20 parts of Rhizoma dioscoreae (parched)s, 20 parts in Radix Glycyrrhizae, 30 parts of Rhizoma Coptidis, above Chinese medicine of the five flavours decoction pieces decocting soup; 5 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Hordei Germinatus (parched)s, 5 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Os Sepiae, 5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 5 parts of Radix Bupleuri, 10 parts of colloidal bismmth pectin, 1 part of oryzanol, 10 parts of Propanthelines.

The preparation method of medicine of the present invention comprises the following steps:

1) weighting raw materials Rhizoma Zingiberis, Fructus Crataegi (parched to brown), Rhizoma dioscoreae (parched), Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Os Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Bupleuri, colloidal bismmth pectin, oryzanol, Propantheline are standby;

2) Rhizoma Zingiberis, Fructus Crataegi (parched to brown), Rhizoma dioscoreae (parched), Radix Glycyrrhizae, the Rhizoma Coptidis with described weight proportion decocts with water twice, and each amount of water was not advisable to have powder, merged decocting liquid twice, filtered to get filtrate;

3) Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Os Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Bupleuri, colloidal bismmth pectin, oryzanol, the Propantheline of described weight proportion are beaten powder with machine, mixing;

4) above-mentioned filtrate is mixed with medicated powder, makes the concentrated pill that diameter is 5mm by machine coating, oven dry, polishing, medicine of the present invention.

Medicine of the present invention can also adopt conventional pharmaceutical methods to make any pharmacy such as powder, tablet, electuary, capsule dosage form for oral administration.

The pharmacological action of each constituent medicine of the present invention is as follows:

The Rhizoma Zingiberis pharmacological action: 1, the effect Rhizoma Zingiberis to digestive system is wind dispelling commonly used, stomachic, and digestion is had slight stimulation, and intestinal tension force, the rhythm and pace of moving things and wriggling are increased.2, the effect alcoholic extract to the cardiovascular-respiratory maincenter has excitation to anesthetized cat vasomotor center and respiratory center, and heart is also had excitation.3, bacteriostasis in vitro tests water logging agent has inhibitory action to trichophyton.4, trichomonas vaginitis there is killing action.Meridian distribution of property and flavor suffering, heat, go into spleen, stomach, lung three warps.Effect cures mainly 1, warming middle-JIAO is nontoxic by the cold big heat of Rhizoma Zingiberis, keeps and does not walk, and the taste cold-evil that can dispel helps the taste yang-energy; No matter all taste cold syndrome are the excess syndromes of invading in the exogenous cold, or the deficiency syndrome of YANG QI deficiency all are suitable for.2, the recuperating depleted YANG expectorant therapeutic method to keep the adverse QI flowing downwards of promoting blood circulation, Rhizoma Zingiberis is hot, and the logical heart is supporing yang, removes the interior cold of dispelling." this thick grass is new " said: " dry spleen is wet and the regurgitation dysentery is controlled in the expectorant of vomitting surely." " Japan hanako materia medica " say: " the expectorant therapeutic method to keep the adverse QI flowing downwards is controlled convulsion and is vomited and diarrhoea, and regurgitation is retched ...." usage and dosage: take, fry in shallow oil soup orally, the 1.5-4.5 gram.

Fructus Crataegi (parched to brown) pharmacological action 1, hypotensive effect 2, increase coronary flow 3, cardiotonic 4, effect for reducing blood fat 5, antibacterial action.Extracorporeal bacteria inhibitor test proves that the Fructus Crataegi (parched to brown) agent all has antibacterial action to will Hayes, this Mi Shi, Fu Shi III type and IIa type, sonne bacillus, bacillus pyocyaneus.Meridian distribution of property and flavor acid, sweet, tepor.Go into spleen, stomach, liver three warps.Effect cures mainly 1, promoting digestion and removing stagnation " Bencao Congxin " is said: " Fructus Crataegi spleen invigorating circulation of qi promoting, the mill that helps digestion is long-pending ... row breast food stops." the Crataegolic acid temperature, the kind smelling of fish or mutton that disappears is greasy long-pending, is the medicine that digests, and is usually used in a little less than the food stagnation spleen gastral cavilty distension etc.2, circulation of qi promoting dissipating blood stasis " Bencao Jingshu " is said: " Fructus Crataegi can go into the taste removing food stagnancy and stagnate, and stagnated blood looses ....On the whole its merit is in strengthening the spleen and stomach, the row stagnation of QI, repercussive blood, thus children's puerpera suitable more than clothes." the little acid gas of sweet in the mouth is flat, the stagnant circulation of qi promoting of being good at disappearing of its property, blood stasis removing blood pain.Usage and dosage: fry in shallow oil soup 9-12 gram.

The Rhizoma dioscoreae (parched) pharmacological action, 1, contained nutritional labeling and phlegmatic temperament, amylase is relevant, and tonic effect is arranged, can be aid digestion.2, antidiarrheal 3, eliminate the phlegm.Meridian distribution of property and flavor is sweet flat, goes into spleen, lung, kidney three warps.Effect cures mainly 1, the strengthening the spleen and nourishing the stomach Compendium of Material Medica is said: " Rhizoma Dioscoreae, kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery.The saliva that reduces phlegm, the profit fur." the Rhizoma Dioscoreae sweet in the mouth, property is flat, can QI invigorating, again can yin nourishing, and effect is gentle.Be flat tonifying the spleen and stomach product commonly used.2, the kidney invigorating arresting seminal emission 3, replenishing and restoring lung-QI 4, arthralgia due to stagnation of blood resistance Lip river 5, emergency detoxifcation usage and dosage: for oral administration, fry in shallow oil soup 15-30 gram.

The effect 3 of Radix Glycyrrhizae pharmacological action 1, Detoxication 2, antiinflammatory and antiallergic action, adrenocortical hormone sample effect 4, to the effect of digestive system.(1) the various preparations to the effect Radix Glycyrrhizae of ulcer have the obvious suppression effect to the experimental gastric ulcer of rat, observe with pharmacology according to clinical, and the Radix Glycyrrhizae water extract can increase " hexosamine " composition of gastric mucosal cell, and gastric mucosa is without prejudice.(2) to after the influencing Radix Glycyrrhizae fluidextract and irritate stomach of gastric juice, can directly adsorb gastric acid,, the basal secretion amount also be had inhibitory action so can reduce acid concentration.(3) spasmolysis Radix Glycyrrhizae decoct, fluid extract all has inhibitory action to the animal intestine in vitro, to acetylcholine, barium chloride, the enterospasm that histamine etc. cause has spasmolysis.Radix Glycyrrhizae is to the stripped gastrointestinal tract of animal and at body relexation is arranged all.5, antitussive effect 6, to lipid metabolism influence 7, to experimental jaundice influence 8, analgesic activity 9, to genitourinary system influence 10, antitumor action 11, toxicity Radix Glycyrrhizae toxicity be very low, but as take for a long time, can cause edema and hypertension.Meridian distribution of property and flavor is sweet flat, nontoxic.Go into the heart, lung, spleen, stomach four warps.Effect cures mainly 1, invigorating the spleen and replenishing QI 2, heat-clearing and toxic substances removing 3, nourishing the lung to arrest cough 4, relieving spasm to stop pain 5, the property of medicine usage and dosage that is in harmonious proportion: for oral administration, and fry in shallow oil soup 2-10 gram, or go into ball, loose.

Rhizoma Coptidis pharmacological action 1, antibacterial action Rhizoma Coptidis or its active ingredient Rhizoma Coptidis have broad-spectrum antibacterial action.In vitro tests has powerful bacteriostasis to staphylococcus, streptococcus, Diplococcus pneumoniae, anthrax bacillus, dysentery bacterium.Inhibition strength to streptococcus pneumoniae, golden Fructus Vitis viniferae is better than penicillin.To bordetella pertussis, significant inhibitory effect is arranged.In addition diphtheria corynebacterium, bacillus pestis, Brucella, Bacillus proteus, Bacillus typhi, tubercule bacillus, leptospira and some common skin funguses also there is stronger antibacterial ability.Experiment showed, that berberine can suppress the carbohydrate metabolism of microorganism, make the oxidizing process of acetone acid be subjected to strong inhibition, find in addition, vitamin B6, the effect of vitamin PP and histidine antagonism berberine is so think that berberine is to have disturbed the utilization of antibacterial to these materials.The synthetic of bacterioprotein also had inhibitory action, and data shows in recent years, and berberine can form complex with deoxyribonucleic, thereby has influenced duplicating of deoxyribonucleic, suppresses the breeding of antibacterial.2, the antivirus action experiment in vitro proves, berberine has obvious inhibitory action to various influenza virus, and new fowl plague virus is also had inhibitory action, and can reduce the positive rate of hepatitis B surface antigen.3, protozoacide effect 4, after entering blood, in body, eliminates rapidly enhance immunity function berberine, blood concentration is difficult for keeping, its vivo bacteria corrosion action is described, be not fully because antibacterial, to influence the body defense function relevant and with it, experimental results show that, berberine in vivo or external equal ability 5 of can leukocyte increasing engulfing staphylococcus aureus, Detoxication 6, antiinflammatory action 7, hypotensive effect 8, choleretic effect 9, the metabolic effect 10 of anticancer anti-radiation and pair cell, the physiological disposition berberine is a quaternary ammonium compounds, oral absorption is relatively poor, the intestinal external administration, be distributed widely in body tissue, the heart, kidney, lung, concentration is higher in the liver.Because absorption is relatively poor, distribute rapidly, elimination is very fast, and haemoconcentration is difficult for keeping, so to application berberine treatment systemic infection, should look state of an illness consideration and select for use.Meridian distribution of property and flavor is bitter, cold.Go into the heart, liver, stomach, large intestine four warps.Effect cures mainly 1, heat clearing and damp drying 2, clearing away heat-fire 3, eliminating fire and detoxication 4, remove infantile malnutrition relieving colic caused by ascaris usage and dosage: 1.5-10 gram, fries in shallow oil soup or goes into ball, looses.

Radix Aucklandiae pharmacological action: 1, antibacterial action Saussurea lappa Clarke water decoction has inhibitory action at test tube to the Salmonella paratyphi first, and some pathomycete is had inhibitory action, but Cryptococcus histolyticus is not then had obvious inhibition.That 2, the hypotensive effect hypotensive effect is the strongest is interior ester oil and 12-Methoxy-ditydrocostundide, mainly is due to peripheral blood vessel expansion and heart suppress.Some lactone separated in the Saussurea lappa Clarke root oil and the effect of going interior ester oil expansion bronchus also to be arranged and bring high blood pressure down also have slight diuresis.3, the spasm of spasmolysis Saussurea lappa Clarke alkaloid part guinea pig bronchial intestinal smooth muscle that histamine is caused has tangible spasmolysis, lactone and go lactone also to have and remove the smooth muscle spasm effect, spasmolysis belongs to together to flesh, similar papaverine and stronger, act on the strongest be in ester oil and dihydro Dehydrocostunolide lactone.The guinea pig bronchial spasm that histamine and acetylcholine are caused has the protective effect of distinct program.Meridian distribution of property and flavor suffering, hardship, temperature.Go into lung, liver, spleen, stomach four warps.Effect cures mainly 1, promoting the circulation of QI to relieve pain Radix Aucklandiae acrid in the mouth is warm in nature, and the hot temperature of loosing is logical, promoting the circulation of QI to relieve pain, and be good at again that a surname stagnates in the accent, be applicable to cards such as gastral cavity abdomen stagnation of QI distending pain.2, warming middle-JIAO for easing the stomach Radix Aucklandiae gas fragrance, say as Compendium of Material Medica: " Radix Aucklandiae is the medicine of three warmers edema caused by disorder of QI, can all gas of lifting." clinically be used for deficiency of spleen-QI and stomach-QI, cards such as the vomiting due to fortuneization is unable, diarrhoea more.3, the inducing diuresis for treating stranguria syndrome Shennong's Herbal is said the Radix Aucklandiae: " main pathogen is warded off malicious epidemic disease, and main the pouring revealed." 4, ward off the poison evil that disappears, the Piization that disappears Disorder usage and dosage: for oral administration, fry in shallow oil soup: 1.5-6 gram, mill juice or go into ball, loose.

Cortex Magnoliae Officinalis (Cortex Magnoliae Officinalis) pharmacological action 1, antibacterial action Cortex Magnoliae Officinalis decoct are in test tube, to streptococcus pneumoniae, diphtheria corynebacterium, Hemolytic streptococcus, bacillus subtilis, will Hayes and Amur dysentery bacterium, staphylococcus aureus etc. have bacteriostasis, in the Cavia porcellus body, anthrax bacillus there is some antibacterial action, some dermatophytess are had an inhibitory action external.2, other effect Cortex Magnoliae Officinalis decocts are to the intestine in vitro of mice and Cavia porcellus, and low dose of appearance is excited, and heavy dose then for suppressing, smoothly also has excitation to Cavia porcellus.Meridian distribution of property and flavor hardship, suffering, temperature.Go into spleen, lung, stomach, large intestine four warps.Effect cures mainly 1, dampness is loose expires the Cortex Magnoliae Officinalis toil and temperature, and dry kind the loosing of property removed full key medicine for dampness, and all damps are held back the distension and fullness in the abdomen due to the resistance, all can suit.2 help digestion, and the painful abdominal mass Cortex Magnoliae Officinalis happiness of loosing is arrogated to oneself and is removed fullly, and the merit of removing food stagnancy is arranged, and stomach internal organs excess pathogen is stagnant, and distension and fullness in the abdomen pain all can be selected for use.3, the lowering the adverse-rising QI to subdue asthma Cortex Magnoliae Officinalis can be descended lung qi, and expectorant saliva and relievining asthma is usually used in a little less than the deficiency of the lung spleen, gives birth in expectorant is turbid, and superinverse is retched.4, cholera and stomachache usage and dosage: take, fry in shallow oil soup orally, the 3-9 gram, or go into ball, diffusing.

Fructus Hordei Germinatus (parched) pharmacological action 1, digestion-aid effect human experimentation show that the Fructus Hordei Germinatus decoct has slight facilitation to gastric acid and pepsic secretion.2, oral rabbit and the normal person's blood glucose of making of hypoglycemic activity Fructus Hordei Germinatus preserved material reduces.3, epinephrine sample effect hordenine belongs to the sympathomimetic amine class, and its pharmacological action characteristics are similar to epinephrine, can be excited myocardium, and vasoconstrictive, expansion bronchus suppresses enterokinesia.4, toxic reaction clinical practice Fructus Hordei Germinatus preparation, toxicity is little, has no adverse reaction, and contains poisonous composition-candine in the root of Cornu Cervi Pantotrichum, and promptly N-methyl hordenine belongs to rapid depolarization type muscle relaxant.When the mass rearing domestic animal, could poison for general.Meridian distribution of property and flavor is sweet flat.Go into spleen, stomach, liver three warps.Effect cures mainly 1, the therapeutic method to keep the adverse QI flowing downwards helps digestion this product function therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, and helping digestion, it is full to remove." property of medicine opinion " said: " the digestion dyspepsia, broken cold air removes trusted subordinate's distension." card such as distension and fullness in the abdomen commonly used.2 and the sweet temperature compensation of middle appetizing this product poor, kind invigorating middle warmer stomach function regulating, ascending the clear and descending the turbid often can be used for vomiting, has loose bowels and disease such as inappetence.3, the diffusing soothing the liver circulation of qi promoting of principal product function tool of circulation of qi promoting, the effect of the broken knot of blood that looses.Usage and dosage: 9-15 gram for oral administration.

Endothelium Corneum Gigeriae Galli pharmacological action 1, to the human stomach function influence Endothelium Corneum Gigeriae Galli itself only contain the trace pepsin and amylase, the secretory volume of gastric juice is increased and stomach motion enhancing, think because Endothelium Corneum Gigeriae Galli is digested and assimilated the back by the event of the neuromuscular device of the excited coat of the stomach of humoral factor.Also there is the gastric hormone of thinking to promote the stomachial secretion function.Gastric hormone can destroy through high heat, is good to give birth to little stir-fry generally.2, quicken drainage 3, the antitumaous effect experiment in vitro of radiostrontium, Endothelium Corneum Gigeriae Galli has the effect that suppresses tumor cell.4, strong, astriction is arranged.Meridian distribution of property and flavor is sweet, flat, goes into spleen, stomach, large intestine, bladder four warps.Effect cures mainly 1, relieving dyspepsia this product is a film within the chicken stomach, and the power that helps digestion is very strong, and sweet in the mouth can the spleen invigorating stomach strengthening, is the spleen invigorating relieving dyspepsia stagnant quality goods that disappear.2, alleviating distention in middle-JIAO spleen invigorating this product is sweet flat, returns the taste warp, and the merit of invigorating the spleen and regulating the stomach is arranged, and helps burnt fortuneization lifting in the fortune, can control having loose bowels of weakness of the spleen and stomach, the regurgitation vomiting of abnormal ascending-descending of QI.3, the removing toxic substances and promoting subsidence of swelling sweet in the mouth can ease up, and cold nature can heat clearing away, and the power of removing toxic substances and promoting subsidence of swelling is arranged.4, astringent or styptic treatment for spontaneous sweatingly only lose 5, diuresis promoting 6, heat extraction end tired 7, expelling pus and promoting granulation 8, eliminating stagnation repercussive 9, preventing the attack (or recurrence) of malaria usage and dosage: for oral administration: fry in shallow oil soup, 3-9 gram or go into ball looses.

Contained calcium carbonate in the Os Sepiae pharmacological action Os Sepiae can be made antacid.The effect that stops gastric acid secretion is arranged.Meridian distribution of property and flavor is salty, and tepor is gone into liver, kidney two warps.Effect cures mainly 1, treating spontaneous emission and leukorrhagia 2, astringing to arrest bleeding 3, relieving gastric hyperacidity to alleviate stomachache stomach discomfort, has a pain during noisy acid regurgitation.This sick modern medicine is thought due to the hyperchlorhydria.The Endoconcha Sepiae puckery, slightly warm in nature can be held back sour stomach function regulating, and relieving gastric hyperacidity to alleviate stomachache is for controlling the good merchantable brand of hyperchlorhydria card." modern practical Chinese medicine " is said it and is: " antacid, to hyperchlorhydria, ulcer is effective." 4, removing dampness holds back skin ulcer 5, relieving diarrhea with astringents 6, Tong Jing Xiao WEIJIA usage and dosage: for oral administration, fry in shallow oil soup 4.5-9 gram, or go into ball, loose.

Pseudobulbus Bletillae (Rhizoma Bletillae) pharmacological action 1, anastalsis 2, there is the therapeutical effect Pseudobulbus Bletillae (Rhizoma Bletillae) to borrow its high viscosity to experimental stomach, duodenum perforation, form certain thickness gluey film at gastric, thereby make blockage of perforations, gastric content stops to leak outside, be omentum majus, the covering effect of liver etc. causes advantageous conditions.3, other effects are according to preliminary in vitro tests, and Pseudobulbus Bletillae (Rhizoma Bletillae) has weak inhibitory action to tubercule bacillus and Ang Shi microspore Du bacterium difficult to understand.The meridian distribution of property and flavor hardship, sweet, puckery, be slightly cold.Go into lung, liver, stomach three warps.Effect cures mainly 1, the astringing to arrest bleeding Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter sweet puckery, is slightly cold and matter is extremely sticky, is the astringing to arrest bleeding key medicine.Go into lung, stomach two warps again, hold concurrently energy tonification lung, stomach are so the lung gastrorrhagia is more commonly used.2, swollen clearly granulation promoting 3, parasite killing are held back the skin ulcer usage and dosage: for oral administration, and fry in shallow oil soup 3-10 gram, or go into ball, diffusing.

The refrigeration function of Radix Bupleuri pharmacological action 1, refrigeration function recent studies Radix Bupleuri mainly is that the antiinflammatory action intensity of volatile oil 2, calmness, analgesic activity 3, antiinflammatory action saikoside is similar to meticortelone.The swollen hypertrophy of the antibiotic bud of Radix Bupleuri is stronger than exudation effect.Its decoct has certain inhibitory action to Hemolytic streptococcus, tubercule bacillus, vibrio cholera and leptospira.4, antipathogen effect 5, liver influenced meridian distribution of property and flavor hardship, cold.Go into percardium, liver, gallbladder, three warmers.Effect cures mainly 1, treating SHAO YANG disease by mediation 2, soothing liver-QI stomach function regulating 3, ascending up spleen-Qi and Yang 4, soothing liver-QI for relieving depression 5, let out fire 6, eliminating impediment usage and dosage: the 3-10 that dispels the wind gram mutually clearly, decoction, or go into ball, loose.

Colloidal bismmth pectin (tieing up quick) pharmacological action 1, this product have stronger colloid property and can form layer of firm protective layer on gastric mucosas in acid medium; strengthen the barrier action of gastric mucosa; therefore, this product has preferably therapeutical effect 2, this product can kill helicobacter pylori to peptic ulcer and chronic gastritis to help improving the healing rate of peptic ulcer and reduce relapse rate.Clinical trial proves, the adhesiveness of treatment helicobacter pylori negative conversion rate 77.8%3, this product and damaged mucosa has high selectivity, and the anastalsis effect to digestive tract hemorrhage cures mainly gastric and duodenal ulcers, chronic superficial gastritis, chronic atrophic gastritis and digestive tract hemorrhage.Preparation: capsule, every capsule 0.5 gram.

The oryzanol pharmacological action is present in meter sugar and oil, is the mixture based on the ferulic acid ester of three enols.Can adjust vegetative nerve function, reduce the incretion balance obstacle, improve spiritual nervous disorder symptom.Effect cures mainly: be used for autonomic nervous dysfunction (gastrointestinal, Dalosta syndrome) periodic psychosis, and the schizophrenia preiodic type, climacteric syndrome etc., but curative effect is not obvious.Preparation: tablet, every 0.1 gram.

Propantheline (probanthine) pharmacological action 1, stronger atropine-like periphery cholinolytic, Antimuscarinic effect are arranged, weak ganglionic blocking action is also arranged.Its characteristics are for to have selectivity to gastrointestinal smooth muscle, and are so it is stronger to suppress the effect of gastrointestinal smooth muscle, more lasting 2, also have in various degree inhibitory action 3, this product to be difficult for by blood brain barrier, so rare central action to perspiration, saliva and gastric secretion.Effect cures mainly the auxiliary treatment that is mainly used in gastric and duodenal ulcers, also is used for gastritis, pancreatitis, bile excretion obstacle, hyperhidrosis, vomiting during pregnancy and the enuresis etc.Preparation: tablet, every 1.5 gram.

The present invention integrates five kinds of functions: 1, thorough eliminating pylorus; 2, gastric acid inhibitory secretion; 3, protection gastrointestinal mucosa; 4, conditioning patient feelings will changes and function; 5, human body immunity improving power and resistance, thus reach treating both the principal and secondary aspects of a disease, the satisfactory effect of prevention of recurrence.

The specific embodiment

[clinical efficacy test report]

1, physical data

Accept out-patient's totally 869 examples for medical treatment, wherein male 538 examples, women 331 examples, men and women's ratio is 1: 0.6, age 15-30 year 392 examples, 31-40 year 285 examples, 41-50 year 116 examples, 76 examples more than 50 years old.

2, Therapeutic Method

Medicine of the present invention is summed up through clinical trial for many years, for symptoms such as acute or chronic gastritis, functional dyspepsia, duodenitis, duodenal ulcer, antral gastritiss, 15 days is a course of treatment, usage and dosage is: oral, one hour ante cibum, three times on the one, each 6-8 gram is taken a course of treatment or two courses of treatment.

For peptic ulcer, it is best to treat three months effects, takes medicine as follows.Usage and dosage: first month, oral, one hour ante cibum, three times on the one, each 6-8 gram was taken one month; The second month, oral, one hour ante cibum, a twice-daily, sooner or later respectively once, each 6-8 gram was taken one month; Three month, oral, once took one month in last hour by each 6-8 gram for supper.

3, efficacy assessment standard

Produce effects: all clinical symptom disappearance, drug withdrawal are followed up a case by regular visits to and are not seen recurrence more than half a year;

Take a turn for the better: all clinical symptom disappearance, drug withdrawal are followed up a case by regular visits to a light symptoms half a year by chance;

Invalid: it is invalid not meeting effective standard.

4, therapeutic outcome (see Table 1, table 2)

Table 1 is observation of curative effect after treating

Week treatment time	Produce effects		Take a turn for the better		Invalid		Effective percentage %
								The example number	Obvious effective rate %	The example number	Improvement rate %	The example number	Inefficiency %
	1234 (one months) two months three months	321 400 560 600 650	36.9 46 64.4 69 74.8	696 418 365 239 243 211	80 48.1 42 27.5 28 24.3	173 130 104 70 26 8								20 15 12 8.1 3 0.9	80 85 88 92 97 99.1

The various treatment for diseases times of table 2

Acute or chronic gastritis	Functional dyspepsia	Duodenitis	Duodenal ulcer	Antral gastritis	Peptic ulcer
						1-2 course of treatment	1-2 course of treatment	1-2 course of treatment	1-2 course of treatment	1-2 course of treatment	Three months

In a word, in trimestral clinical practice, with medicine of the present invention treatment patient 869 examples, produce effects 650 examples as a result, 211 examples that take a turn for the better, invalid 8 examples, obvious effective rate is 74.8%, and improvement rate is 24.3%, and total effective rate is 99.1%.

Come further to illustrate the preparation method of medicine of the present invention by the following examples.

Embodiment 1

The preparation method step of medicine of the present invention is as follows:

1) weighting raw materials Rhizoma Zingiberis 20 grams, Fructus Crataegi (parched to brown) 10 grams, Rhizoma dioscoreae (parched) 20 grams, Radix Glycyrrhizae 20 grams, Rhizoma Coptidis 30 grams, the Radix Aucklandiae 5 grams, Cortex Magnoliae Officinalis 5 grams, Fructus Hordei Germinatus (parched) 10 grams, Endothelium Corneum Gigeriae Galli gram, Os Sepiae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, Radix Bupleuri 5 grams, colloidal bismmth pectin 10 grams, oryzanol 1 gram, Propantheline 10 grams are standby;

2) Rhizoma Zingiberis, Fructus Crataegi (parched to brown), Rhizoma dioscoreae (parched), Radix Glycyrrhizae, the Rhizoma Coptidis with described weight proportion decocts with water twice, and each amount of water was not advisable to have powder, merged decocting liquid twice, filtered to get filtrate;

3) Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Os Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Bupleuri, colloidal bismmth pectin, oryzanol, the Propantheline of described weight proportion are beaten powder with machine, mixing;

4) above-mentioned filtrate is mixed with medicated powder, makes the concentrated pill that diameter is 5mm by machine coating, oven dry, polishing, medicine of the present invention.

Embodiment 2

Take by weighing Rhizoma Zingiberis 18 grams, Fructus Crataegi (parched to brown) 10 grams, Rhizoma dioscoreae (parched) 19 grams, Radix Glycyrrhizae 22 grams, Rhizoma Coptidis 28 grams, the Radix Aucklandiae 3 grams, Cortex Magnoliae Officinalis 2 grams, Fructus Hordei Germinatus (parched) 11 grams, Endothelium Corneum Gigeriae Galli 6 grams, Os Sepiae 8 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, Radix Bupleuri 6 grams, colloidal bismmth pectin 8 grams, oryzanol 2 grams, Propantheline 12 grams, standby; Its preparation process is with embodiment 1.

Embodiment 3

Take by weighing Rhizoma Zingiberis 22 grams, Fructus Crataegi (parched to brown) 12 grams, Rhizoma dioscoreae (parched) 22 grams, Radix Glycyrrhizae 18 grams, Rhizoma Coptidis 32 grams, the Radix Aucklandiae 6 grams, Cortex Magnoliae Officinalis 2 grams, Fructus Hordei Germinatus (parched) 11 grams, Endothelium Corneum Gigeriae Galli 6 grams, Os Sepiae 8 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 grams, Radix Bupleuri 5 grams, colloidal bismmth pectin 12 grams, oryzanol 1 gram, Propantheline 11 grams, standby.Its preparation process is with embodiment 1.

Claims (3)

1, a kind of medicine for the treatment of gastrointestinal disease is characterized in that it is to be made by following bulk drugs: Rhizoma Zingiberis 18-22 part, Fructus Crataegi (parched to brown) 8-12 part, Rhizoma dioscoreae (parched) 18-22 part, Radix Glycyrrhizae 18-22 part, Rhizoma Coptidis 28-32 part, Radix Aucklandiae 3-6 part, Cortex Magnoliae Officinalis 3-6 part, Fructus Hordei Germinatus (parched) 8-12 part, Endothelium Corneum Gigeriae Galli 3-6 part, Os Sepiae 8-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6 part, Radix Bupleuri 3-6 part, colloidal bismmth pectin 8-12 part, oryzanol 1-2 part, Propantheline 8-12 part.

2, medicine according to claim 1, wherein the best proportioning of crude drug is: 20 parts of Rhizoma Zingiberiss, 10 parts of Fructus Crataegi (parched to brown)s, 20 parts of Rhizoma dioscoreae (parched)s, 20 parts in Radix Glycyrrhizae, 30 parts of Rhizoma Coptidis, 5 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Hordei Germinatus (parched)s, 5 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Os Sepiae, 5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 5 parts of Radix Bupleuri, 10 parts of colloidal bismmth pectin, 1 part of oryzanol, 10 parts of Propanthelines.

3, the preparation method of claim 1 or 2 described medicines, it comprises the following steps:

1) weighting raw materials Rhizoma Zingiberis, Fructus Crataegi (parched to brown), Rhizoma dioscoreae (parched), Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Os Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Bupleuri, colloidal bismmth pectin, oryzanol, Propantheline are standby;

2) Rhizoma Zingiberis, Fructus Crataegi (parched to brown), Rhizoma dioscoreae (parched), Radix Glycyrrhizae, the Rhizoma Coptidis with described weight proportion decocts with water twice, and each amount of water was not advisable to have powder, merged decocting liquid twice, filtered to get filtrate;

3) Radix Aucklandiae, Cortex Magnoliae Officinalis, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Os Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Bupleuri, colloidal bismmth pectin, oryzanol, the Propantheline of described weight proportion are beaten powder with machine, mixing;

4) will go up filtrate and mix, make the concentrated pill that diameter is 5mm by machine coating, oven dry, polishing with medicated powder, medicine of the present invention.