CN121532411A - Systems and methods for regulating target genes - Google Patents

Abstract

Provided herein are compositions, methods, and systems for modulating expression of a target gene (e.g., a target endogenous gene). In some embodiments, an engineered gene effector is provided that comprises a first peptide that is 75-95 amino acids in length and a second peptide that is 75-95 amino acids in length. Engineered gene effectors may facilitate modulation of the expression level or activity level of a target gene when brought into proximity with the target gene or target gene regulatory sequence as a complex with a targeting moiety (e.g., a heterologous endonuclease). Also provided are computer-implemented methods for producing functional biological sequences, as well as functional biological sequences, such as engineered gene effectors made by the methods.

Description

Systems and methods for modulating a target gene

Reference to priority applications

The present application claims priority from U.S. provisional application number 63/504661 filed on month 5 of 2023, U.S. provisional application number 63/520561 filed on month 8 of 2023, U.S. provisional application number 63/502891 filed on month 5 of 2023, U.S. provisional application number 63/504660 filed on month 5 of 2023, and U.S. provisional application number 63/504663 filed on month 5 of 2023. The contents of each of these above-mentioned applications are expressly incorporated herein by reference in their entirety.

Reference to sequence Listing

The present application is presented with a sequence listing in electronic format. The sequence listing is provided in a file named EPICR019WOSequenceListing. Xml, created at 2024, month 5, 14, and having a size of 2506752 bytes. The electronically formatted information of the sequence listing is incorporated by reference in its entirety.

Background

Various effector agents (e.g., transcriptional regulatory factors) may be utilized to regulate expression or activity of a target gene in a cell. For example, a heterologous gene effector can be introduced (e.g., delivered, expressed, etc.) into a cell, and the heterologous gene effector can affect such modulation of a target gene, alone or in combination with additional agents. In some examples, the additional agent may include Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) for specific binding to a target gene (e.g., a target deoxyribonucleic acid (DNA) sequence or ribonucleic acid (RNA) sequence (e.g., an exogenous DNA sequence or RNA sequence) of the target gene), while the heterologous gene effector may regulate expression or activity level of the target gene. Such gene effectors may be used, for example, as gene therapy to treat or ameliorate a condition (e.g., a disease) in a subject.

Disclosure of Invention

Provided herein are engineered gene effectors comprising a polypeptide comprising a first peptide of 75-110 (or 75-95) amino acids in length, wherein the first peptide comprises any one of SEQ ID nos. 3-100, or a sequence at least 85% identical thereto, and a second peptide of 75-110 (or 75-95) amino acids in length and heterologous to the first peptide, wherein the second peptide comprises any one of SEQ ID nos. 3-100, or a sequence at least 85% identical thereto, optionally wherein the first peptide is different from the second peptide.

Also provided are engineered gene effectors comprising a polypeptide comprising a first peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator and a second peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator, wherein the second peptide is heterologous to the first peptide, wherein the engineered gene effectors are capable of activating a target gene in a cell when expressed in the cell and effectively targeted to a site of the target gene.

Provided herein are fusion proteins comprising an engineered gene effector of the present disclosure, and a heterologous endonuclease coupled to a polypeptide, optionally wherein the heterologous endonuclease is a Cas protein.

Also provided are systems comprising an engineered gene effector of the present disclosure, a heterologous endonuclease coupled to a polypeptide of the engineered gene effector, optionally wherein the heterologous endonuclease is a Cas protein, and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell.

Also provided are combinations of polynucleotides encoding the systems of the present disclosure, wherein the combinations of polynucleotides are configured to express in a cell a heterologous endonuclease coupled to an engineered gene effector, and a guide nucleic acid.

Further provided are kits comprising any of the engineered gene effectors, fusion proteins, combinations, systems, polynucleotides, vectors, and/or cells of the disclosure.

Also provided are methods of controlling a target gene in a cell comprising contacting the cell with an engineered gene effector, fusion protein, polynucleotide, vector, system, or combination of polynucleotides of the present disclosure.

Further provided is a computer-implemented method of generating a functional biological sequence, the method comprising (a) providing an fitness function trained on a biological dataset comprising functionally determined biological sequences having a fixed length; providing in a computer a plurality of different sequences comprising a fixed length, each sequence being associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of a temperature gradient, (c) by the computer, in parallel, (1) selecting one or more random positions for introducing substitutions in one or more sequences of the plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and for each of the one or more sequences, evaluating a first fitness change due to introducing substitutions at one or more randomly selected positions, and accepting or rejecting substitutions based on the evaluated first fitness change, and optionally further based on the temperature associated with the sequence, and/or (2) selecting one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a consecutive temperature of the temperature gradient, optionally selecting 3 of the plurality of different sequences, optionally selecting one or more pairs of selected pairs, and for producing a domain between the selected pairs of the plurality of selected pairs, and the domain is evaluated due to the selected pairs, and accepting or rejecting one or more domain exchanges between the selected pairs based on the fitness differences and the temperatures associated with each sequence of the selected pairs, and (d) iteratively performing (c), wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domain exchanges of a previous iteration are incorporated into a plurality of different sequences, thereby producing one or more functional sequences having fitness that meets or exceeds a desired fitness threshold.

In one aspect, a computer-implemented method of generating a functional biological sequence is provided, the computer-implemented method comprising (a) evaluating, by a computer, a sequence of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functional biological sequences having the fixed length, (b) replacing, by the computer, one or more random residues in the sequence to generate a mutant sequence, (c) evaluating, by the computer, the mutant sequence based on the fitness function, and (d) collecting, by the computer, the functional sequence accepted by the fitness function. In some cases, the functional biological sequence comprises an amino acid sequence or a nucleotide sequence of a protein or peptide. In some cases, the protein or peptide is an epigenetic regulator, transcription factor, enzyme, nuclease, agonist, antagonist, regulatory factor, or inhibitor. In some cases, the functional biological sequence comprises an amino acid sequence or a nucleotide sequence. In some cases, the functional biological sequence comprises an amino acid sequence, and further wherein the fixed length is at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60, at least 65, at least 70, at least 75, at least 80, at least 85, at least 90, at least 95, at least 100, at least 105, at least 110, at least 115, at least 120, at least 125, at least 130, at least 140, at least 150, or at least 200 amino acids. In some cases, the fitness function is based on one or more machine learning models, wherein the machine learning model is selected from the group consisting of a supervised machine learning model, an unsupervised machine learning model, a reinforcement learning model, a deep learning model, a transfer learning model, and any combination thereof. In some cases, the one or more machine learning models are selected from the group consisting of classification models, regression models, convolutional Neural Networks (CNNs), recurrent Neural Networks (RNNs), limit gradient boosting (XGBoost), long-short term memory networks, generation of countermeasure networks (GANs), automatic encoders, transformer networks, evolutionary Monte Carlo (evolutionary Monte Carlo), and any combination thereof. In some cases, the computer-implemented method further comprises randomly exchanging, by the computer, one or more subsequences from the mutated sequence and a different sequence of the plurality of sequences. In some cases, the fitness function includes a threshold selected from the group consisting of a binary threshold, a numeric threshold, a multi-class threshold, a confidence threshold, a decision threshold, and any combination thereof. In some cases, the fitness function accepts the functional sequence when the fitness score assigned to the functional sequence by the fitness function meets or exceeds a threshold.

In another aspect, a computer-implemented system is provided that includes a computing device including at least one processor and instructions executable by the at least one processor to provide an application program including (a) a software module configured to evaluate, by a computer, sequences in a plurality of different sequences including a fixed length based on an fitness function trained on a biological dataset including functional biological sequences having the fixed length, (b) a software module configured to replace, by the computer, one or more random residues in the sequences to generate a mutant sequence, (c) a software module configured to evaluate, by the computer, the mutant sequence based on the fitness function, and (d) a software module configured to collect, by the computer, the functional sequences accepted by the fitness function.

In another aspect, a non-transitory computer readable medium having stored thereon computer readable instructions that, when executed by a processor, cause the processor to perform a method comprising (a) evaluating sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functional biological sequences having the fixed length, (b) replacing one or more random residues in the sequences to generate a mutant sequence, (c) evaluating the mutant sequence based on the fitness function, and (d) collecting the functional sequences accepted by the fitness function is provided.

Provided herein are engineered gene effectors comprising a polypeptide of 85 amino acids in length comprising any one of SEQ ID NOs 1495, 1592, 1595, 1634, 1654, 1665, 1677, 1686, 1689, 1716, or a sequence at least 85% identical thereto.

There is also provided a computer-implemented system comprising a computing device comprising at least one processor and instructions executable by the at least one processor to provide an application comprising (a) a software module configured to provide, by the computer, a fitness function trained on a biological dataset comprising functionally determined biological sequences having a fixed length, (b) a software module configured to provide, by the computer, a plurality of different sequences comprising a fixed length, each sequence being associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of a temperature gradient, (c) a software module in parallel with the plurality of different sequences, (1) the software module being configured to select, by the computer, one or more random positions for introducing substitutions in one or more sequences of the plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and for one or more sequences, each sequence being associated with a temperature gradient based on the one or more random sequences, and further evaluating, by the one or more random sequences and/or more random positions being included in the plurality of sequences, the software module being further associated with the temperature gradient based on the one or more random sequences being selected and the fitness being evaluated based on the one or more random sequences, optionally selecting up to 3 pairs of the plurality of different sequences, optionally selecting 1 pair of the plurality of different sequences, and for each selected pair selecting one or more domains for exchange between sequences of the selected pair, and evaluating the fitness differences of sequences of the selected pair due to the exchange of one or more domains, and accepting or rejecting one or more domain exchanges between the selected pair based on the fitness differences and a temperature associated with each sequence of the selected pair, and (d) a software module configured to iteratively execute (c) by the computer, wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domain exchanges of a previous iteration are incorporated into the plurality of different sequences, thereby producing one or more functional sequences having a fitness that is at or above a desired fitness threshold.

Also provided are engineered gene effectors comprising a polypeptide comprising any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

Provided herein are engineered gene effectors comprising a polypeptide comprising any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, or sequences at least 85% identical thereto, or sequences having 0-3 amino acid residue mutations, optionally, wherein any mutation thereof is a conservative substitution.

Drawings

The novel features of the disclosure are set forth with particularity in the appended claims. The features and advantages of the present disclosure will be better understood by reference to the following detailed description, which sets forth exemplary embodiments utilizing the principles of the present invention, and the accompanying drawings.

FIG. 1A shows activation of GFP reporter genes by single gene regulators or by combination gene regulators.

FIG. 1B shows the synergistic effect of activation of the combinatorial gene modulators.

FIG. 2A shows the distribution of selected candidate gene regulators.

FIG. 2B shows the activation levels of the combination gene modulators (weak, medium, and strong).

FIG. 2C shows homologous clustering of candidate modulators.

FIG. 2D shows predicted protein domains of candidate modulators.

FIG. 3A shows cloning strategies for screening for combinatorial gene modulators.

FIG. 3B shows the GFP reporter design for evaluation of gene regulation by the combination gene regulators.

FIG. 3C shows the validation of the combined gene modulator reversible recruitment by the reporting system.

FIG. 4 shows GFP expression of the combination gene regulators.

FIG. 5A shows DESEQ analysis of combinatorial gene modulators.

FIG. 5B shows the level of activation of a combined gene regulator source (e.g., human-human vs virus).

Fig. 5C shows a heat map indicating the activation states of all the combination modulators.

Fig. 6A shows an analysis of biochemical and biophysical characteristics of a combination modulator by evaluating electrostatic potential.

FIG. 6B shows an analysis of biochemical and biophysical characteristics of the combination modulator by evaluating the B_beta factor.

FIGS. 7A-7B depict the activation of epigenetic silenced loci (CD 45) by engineered gene effectors in HEK 293. Some of the engineered gene effectors detected comprise a first peptide and a second peptide. Some of the engineered gene effectors detected are encoded by functional biological sequences generated using computer-implemented methods.

FIG. 8 depicts reactivation of epigenetic silenced loci by engineered gene effectors in human cells. Some of the engineered gene effectors detected comprise a first peptide and a second peptide. Some of the engineered gene effectors detected were generated using computer-implemented methods that produced functional biological sequences.

Fig. 9A-9D provide non-limiting examples of exemplary methods of generating biofunctional sequences in accordance with embodiments of the present disclosure.

FIG. 10 depicts a graph of predicting minimum edit distances of a biofunctional sequence relative to sequences in an original training dataset using the methods and systems provided herein.

FIG. 11 depicts a representation of predicting sequences having biological functions in two-dimensional space using the methods and systems provided herein.

FIG. 12A depicts a non-limiting example of a migration learning method using LPLM inserts to predict gene activators from sequences.

Fig. 12B depicts a non-limiting example of a fitness view representing the effective search space of MHMCS (pink) and EMCS (blue). MHMCS search locally for regions of high fitness near the starting molecule, while EMCS interpolates between starting points and changes the search speed to optimize the search.

Fig. 13 depicts Principal Component Analysis (PCA) of the original training set with new sequences designed by using OneHot-encoded EMCS and MHMCS.

Fig. 14A depicts the entropy change distribution for 107 MHMCS and EMCS initial iterations using default parameters. From an informative perspective, EMCS explores a larger region of the fitness space per iteration than MHMCS.

Fig. 14B depicts i) iterations from random predetermined sequences to convergence (f≥0.95) for 2361 sequences obtained by running 2571 times MHMCS at t=2.5x10 ^-3、10^-4, ii) iterations from 1171 sequences obtained by running 1171 times EMCS at default parameters to convergence, iii) the number of iterations to convergence and/or positive hits (f≥0.5) for 2571 sequences of 2571 times MHMCS running at t=2.5x10 ^-3、10^-4. 210 of 2571 sequences failed to converge (but successfully produced a positive hit (f > 0.5)), iv) 2720 sequences obtained by running 1171 EMCS under default parameters reached an iteration of converging and/or positive hits, yielding an average of 2.32 positive hits per EMCS run of 4 chains.

Fig. 15 depicts a schematic of fitness graph exploration using novel EMCS, which includes domain exchange between peptide chains. The EMCS algorithm comprises the following components of 1) parallel Metropolis-Hastings Monte Carlo (MHMCS) operation, 2) temperature gradient implementation (parallel tempering), and 3) domain exchange between peptide chains (EMCS) parallel operation.

FIGS. 16A-16B depict the entropy change distribution and convergence time of MHMCS and EMCS iterations. For ablation studies, PTP (parallel tempering) and EMC-NPT (EMCs without parallel tempering) were run.

Fig. 17 depicts Fluorescence Activated Cell Sorting (FACS) histograms from engineered gene effector validation experiments. The ability of the engineered gene effectors encoded by 4600 new sequences to activate synthetic gene loci was tested. 357 out of 4600 engineered gene effectors (hit rate 7.51%) significantly activated the gene reporter compared to background fluorescence.

Fig. 18A-18C depict biochemical and structural characterization analysis of experimentally verified functional biological sequences using ESMFold.

FIGS. 19A-19B depict engineered gene effector validation assays performed in HEK293 cells. 10 engineered gene effectors (SEQ ID NOS: 1495, 1592, 1595, 1634, 1654, 1665, 1677, 1686, 1689, 1716) were screened at the synthesis site (TRE 3G) and the endogenous site (CD 45), respectively. The activation potency of the engineered gene effector was compared to the activation potency of the standard activators VP64 and vCD.

FIG. 20 depicts a non-limiting computer system programmed or otherwise configured to implement the methods provided herein.

Fig. 21A and 21B are schematic diagrams illustrating a non-limiting embodiment of a computer-implemented method of the present disclosure.

Detailed Description

SUMMARY

Aspects of the disclosure may provide engineered effectors (or engineered gene effectors, used interchangeably herein) capable of modulating (e.g., activating or reducing) the expression or activity level of a target gene (e.g., an endogenous target gene, a heterologous target gene, etc.) in a cell, compositions, combinations, systems, and methods of using the same. Such engineered effectors may work with a heterologous endonuclease (e.g., an engineered CRISPR/Cas nuclease or inactive variant thereof), e.g., to affect manipulation of expression or activity levels of a target gene in a cell, e.g., for treating or ameliorating a disorder (e.g., a disease) in a subject. Gene expression can support a variety of physiological and pathological effects in cells and tissues, leading to a number of diseases and disorders, and thus compositions, combinations, systems and methods utilizing engineered gene effectors of the present disclosure can modulate expression of specific genes in a desired manner, thereby having therapeutic benefits.

CRISPR-mediated transcriptional regulation has a wide range of potential applications in synthetic biology and gene therapy. Transcriptional activation in eukaryotes depends on complex interactions of a variety of factors including DNA binding transcription factors, coactivators, chromatin remodeling factors, and underlying transcription mechanisms. These multiple inputs typically exhibit a synergistic relationship whereby the transcriptional output driven by two or more factors is greater than the sum of the outputs driven by each factor individually. Preliminary screening has found hundreds of small peptides (85 aa) derived from endogenous human, viral and archaeal proteins that, when fused to programmable DNA in combination with dCas protein, activate transcription to varying degrees.

Described herein are platforms for screening pairwise combinations of these activation domains in an inducible and reversible manner for increasing activity determined by both the magnitude and duration of transcriptional output. The screen identified about 1400 new combinations and the activating factors of these combinations showed stronger activity than their constituent parts. These combined activators are strongest when one of the chaperone blocks has a viral origin. Machine learning methods are further described herein to identify a set of chaperone blocks that best predicts strong combined activators, including classical viral activators (e.g., VP 64), novel viral activators (e.g., vIRF2/vIRF 4), and human activators (e.g., LEUTX).

Analysis of biochemical and biophysical characteristics is provided herein, indicating that strong combinations have a high negative electrostatic potential and tend to have structural flexibility. Computer-simulated structural predictions of previous hits show that stable intramolecular interactions between helices can stabilize strongly combined interaction interfaces and can be functionally related to transcriptional activation. Further provided herein are new kits of tools for combining transcription regulatory factors with potential that have not yet been developed, as well as platforms for discovering additional tools for use in both basic research and therapy.

In some embodiments, the engineered gene effectors of the present disclosure include a fusion of two different gene effectors, e.g., when used with a heterologous endonuclease, the fusion provides for regulation of gene expression. In some embodiments, modulation of gene expression by a fusion of two different gene effectors provides a superior effect (e.g., a prolonged duration of modulated expression) compared to the effect provided by each component alone

Designing new protein sequences is still a slow and expensive process due to various protein engineering challenges, and in particular, the number of protein variants that can be experimentally tested in a given assay is dwarfed compared to the broad overall sequence space (which results in low hit rates and expensive wet laboratory test cycles). Provided herein are computer-implemented methods and systems for producing functional biological sequences (e.g., engineered gene effectors). In some embodiments, computer-implemented methods and systems accelerate the discovery of new functional sequences (e.g., new functional amino acid sequences). In some embodiments, computer-implemented methods and systems generate new biofunctional sequences in a time-and cost-effective manner.

Terminology

As used herein, the term "heterologous" when used in reference to a polypeptide sequence or nucleic acid sequence means that the polypeptide sequence or nucleic acid sequence (1) is placed (e.g., in the context of a cell, virus, or fusion polypeptide molecule, or fusion polynucleotide molecule, etc.) where it is not normally present (e.g., not normally present in nature), or (2) includes two or more subsequences that have a relationship different from that normally present in nature. For example, a polypeptide may comprise a first polypeptide sequence and a second polypeptide sequence that do not occur together in a single polypeptide in nature, and thus the first polypeptide sequence and the second polypeptide sequence may be heterologous to each other. In another example, a polynucleotide may comprise a first polynucleotide sequence and a second polynucleotide sequence that do not occur together in a single polynucleotide in nature, and thus the first polynucleotide sequence and the second polynucleotide sequence may be heterologous to each other.

The term "cell" generally refers to a biological cell. The cells may be the basic structural, functional and/or biological units of an organism. The cells may be derived from any organism having one or more cells. Some non-limiting examples include prokaryotic cells, eukaryotic cells, bacterial cells, archaebacterial cells, unicellular eukaryotic cells, protozoal cells, cells from plants (e.g., cells from crops, fruits, vegetables, grains, soybeans, corn, maize, wheat, seeds, tomatoes, rice, tapioca, sugarcane, pumpkin, hay, potatoes, cotton, hemp, tobacco, flowering plants, conifers, gymnosperms, ferns, pinus, goldfish algae, liverwort, moss cells), algal cells (e.g., bronzes (Botryococcus braunii), chlamydomonas reinharderia (Chlamydomonas reinhardtii), nannochloropsis gaditana, pyrenoids (Chlorella pyrenoidosa), sargassum (Sargassum) c. Agardh, etc.), seaweed (e.g., kelp), fungal cells (e.g., yeast cells, cells from mushrooms, animal cells, cells from invertebrates (e.g., flies, spines, echinoderms, nematodes, etc.), vertebrate cells (e.g., fish, reptiles, animal cells, rodent, rat, mouse, etc.), non-human, etc. Sometimes, the cells are not derived from a natural organism (e.g., the cells may be synthetically manufactured, sometimes referred to as artificial cells).

As used herein, the term "nucleotide" generally refers to a base-sugar-phosphate composition. The nucleotides may comprise synthetic nucleotides. The nucleotide may comprise a synthetic nucleotide analogue. Nucleotides may be monomeric units of nucleic acid sequences such as deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The term nucleotide may include ribonucleoside triphosphates (adenosine triphosphate (ATP), uridine Triphosphate (UTP), cytidine Triphosphate (CTP), guanosine Triphosphate (GTP)) and deoxyribonucleoside triphosphates (e.g., dATP, dCTP, dITP, dUTP, dGTP, dTTP) or derivatives thereof. Such derivatives may include, for example, [ αS ] dATP, 7-deaza-dGTP, and 7-deaza-dATP, as well as nucleotide derivatives that confer nuclease resistance on nucleic acid molecules containing them. The term nucleotide as used herein may refer to dideoxyribonucleoside triphosphates (ddntps) and their derivatives. Illustrative examples of dideoxyribonucleoside triphosphates may include, but are not limited to ddATP, ddCTP, ddGTP, ddITP and ddTTP. The nucleotides may be unlabeled or may be detectably labeled by known techniques. Marking may also be implemented with quantum dots. Detectable labels may include, for example, radioisotopes, fluorescent labels, chemiluminescent labels, bioluminescent labels, and enzyme labels. Fluorescent labels for nucleotides may include, but are not limited to, fluorescein, 5-carboxyfluorescein (FAM), 2',7' -dimethoxy-4 ',5' -dichloro-6-carboxyfluorescein (JOE), rhodamine, 6-carboxyrhodamine (R6G), N, N, N ', N' -tetramethyl-6-carboxyrhodamine (TAMRA), 6-carboxy-X-Rhodamine (ROX), 4- (4 '-dimethylaminophenylazo) benzoic acid (DABCYL), cascade Blue, oregon Green, texas Red, cyanine, and 5- (2' -aminoethyl) aminonaphthalene-1-sulfonic acid (EDANS). Specific examples of fluorescent-labeled nucleotides may include [R6G]dUTP、[TAMRA]dUTP、[R110]dCTP、[R6G]dCTP、[TAMRA]dCTP、[JOE]ddATP、[R6G]ddATP、[FAM]ddCTP、[R110]ddCTP、[TAMRA]ddGTP、[ROX]ddTTP、[dR6G]ddATP、[dR110]ddCTP、[dTAMRA]ddGTP and [ dROX ] ddTTP available from PERKIN ELMER (Foster City, calif.), fluoroLink deoxynucleotides available from Amersham (Arlington Heights, ill.), fluoroLink Cy3-dCTP, fluoroLink Cy5-dCTP, FluoroLink Fluor X-dCTP, fluoroLink Cy-dUTP and FluoroLink Cy-dUTP, fluorescein-15-dATP, fluorescein-12-dUTP, tetramethyl-rhodamine-6-dUTP, IR770-9-dATP, fluorescein-12-ddUTP, fluorescein-12-UTP and fluorescein-15-2' -dATP obtainable from Boehringer Mannheim (Indianapolis, ind.), and the chromosome-tagged nucleotide 、BODIPY-FL-14-UTP、BODIPY-FL-4-UTP、BODIPY-TMR-14-UTP、BODIPY-TMR-14-dUTP、BODIPY-TR-14-UTP、BODIPY-TR-14-dUTP、Cascade Blue-7-UTP、Cascade Blue-7-dUTP、 fluorescein-12-UTP, available from Molecular Probes (Eugene, oreg.), fluorescein-12-dUTP, oregon Green 488-5-dUTP, rhodamine Green-5-dUTP, tetramethyl rhodamine-6-UTP, tetramethyl rhodamine-6-dUTP, texas Red-5-dUTP, and Texas Red-12-dUTP. nucleotides may also be labeled or tagged by chemical modification. The chemically modified mononucleotide may be biotin-dNTP. Some non-limiting examples of biotinylated dNTPs may include biotin-dATP (e.g., bio-N6-ddATP, biotin-14-dATP), biotin-dCTP (e.g., biotin-11-dCTP, biotin-14-dCTP), and biotin-dUTP (e.g., biotin-11-dUTP, biotin-16-dUTP, biotin-20-dUTP).

The terms "polynucleotide", "oligonucleotide" or "nucleic acid" are used interchangeably herein to refer generally to a polymeric form of nucleotides of any length, whether deoxyribonucleotides or ribonucleotides, or analogs thereof, whether in single-stranded, double-stranded or multi-stranded form. Polynucleotides may be exogenous or endogenous to the cell. The polynucleotide may be present in a cell-free environment. The polynucleotide may be a gene or fragment thereof. The polynucleotide may be DNA. The polynucleotide may be RNA. Polynucleotides may have any three-dimensional structure and may perform any function, known or unknown. Polynucleotides may comprise one or more analogs (e.g., engineered backbones, sugars, or nucleobases). Modification (if present) of the nucleotide structure may be performed before or after assembly of the polymer. Some non-limiting examples of analogs include 5-bromouracil, peptide nucleic acids, xenogenic nucleic acids (xeno nucleic acid), morpholinos, locked nucleic acids, ethylene glycol nucleic acids, threose nucleic acids, dideoxynucleotides, cordycepin, 7-deaza-GTP, fluorophores (e.g., sugar linked rhodamine or fluorescein), sulfhydryl-containing nucleotides, biotin linked nucleotides, fluorescent base analogs, cpG islands, methyl-7-guanosine, methylated nucleotides, inosine, thiouridine (thiouridine), pseudouridine, dihydrouridine, queuosine, and wyosine. Non-limiting examples of polynucleotides include coding or non-coding regions of genes or gene fragments, loci defined by linkage analysis (locus), exons, introns, messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), short interfering RNA (siRNA), short hairpin RNA (shRNA), microRNA (miRNA), ribozymes, cDNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, cell-free polynucleotides including cell-free DNA (cfDNA) and cell-free RNA (cfRNA), nucleic acid probes, and primers. The nucleotide sequence may be interrupted by non-nucleotide components.

The term "sequence identity" generally refers to the exact nucleotide-to-nucleotide, or amino acid-to-amino acid correspondence of two polynucleotide sequences or polypeptide sequences, respectively. In general, techniques for determining sequence identity include determining the nucleotide sequence of a polynucleotide and/or determining the amino acid sequence encoded thereby, and comparing these sequences to a second nucleotide sequence or amino acid sequence. By determining their "percent identity", two or more sequences (polynucleotides or amino acids) can be compared. The percent identity of two sequences, whether nucleic acid sequences or amino acid sequences, is the number of exact matches between the two aligned sequences divided by the length of the longer sequence and multiplied by 100. The percent identity can also be determined, for example, by comparing sequence information using an advanced BLAST computer program available from the national institutes of health, including version 2.2.9. The BLAST program is based on the alignment of Karlin and Altschul, proc. Natl. Acad. Sci. USA, 87:2264-2268 (1990), and is discussed in Altschul et al, J. Mol. Biol., 215:403-410 (1990), karlin and Altschul, proc. Natl. Acad. Sci. USA, 90:5873-5877 (1993), and Altschul et al, nucleic Acids Res., 25:3389-3402 (1997). This procedure can be used to determine the percent identity over the full length of the proteins being compared. Default parameters are provided, for example, in the blastp program to optimize retrieval of the short query sequence. The program also allows the use of SEG filters to mask fragments of query sequences determined by the SEG program of Wootton and Federhen, computers AND CHEMISTRY 17:149-163 (1993). The desired degree of sequence identity ranges from about 50% to 100% and integer values therebetween. In general, the present disclosure encompasses sequences having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, or at least 98% sequence identity to any one of the sequences provided herein.

The term "gene" generally refers to a nucleic acid (e.g., DNA, such as genomic DNA and cDNA) and its corresponding nucleotide sequence that is involved in encoding an RNA transcript. The term used herein to refer to genomic DNA includes non-coding regions in the middle as well as regulatory regions, and may include the 5 'and 3' ends. In some uses, the term comprises transcribed sequences, including the 5 'untranslated region and the 3' untranslated region (5 '-UTR and 3' -UTR), exons, and introns. In some genes, the transcribed region will comprise an "open reading frame" encoding the polypeptide. In some uses of this term, a "gene" comprises only the coding sequences (e.g., an "open reading frame" or "coding region") necessary to encode a polypeptide. In some cases, the gene does not encode a polypeptide, such as a ribosomal RNA gene (rRNA) and a transfer RNA (tRNA) gene. In some cases, the term "gene" includes not only transcribed sequences, but also additionally non-transcribed regions comprising upstream and downstream regulatory regions, enhancers and promoters. A gene may refer to an "endogenous gene" or a native gene in a native location in the genome of an organism. Genes may be referred to as "exogenous genes" or non-native genes. Non-native genes may refer to genes that are not normally found in the host organism, but are introduced into the host organism by gene transfer. Non-native genes may also refer to genes that are not naturally located in the genome of an organism. Non-native genes may also refer to naturally occurring nucleic acid or polypeptide sequences (e.g., non-native sequences) that comprise mutations, insertions, and/or deletions.

The term "deletion" generally refers to the removal (or loss) of one or more (or a specified number of) amino acids (e.g., contiguous or non-contiguous amino acids) from a polypeptide sequence, or the removal (or loss) of one or more (or a specified number of) nucleobases (e.g., contiguous or non-contiguous nucleobases) from a polynucleotide sequence (e.g., a polynucleotide sequence encoding a polypeptide sequence). The term "internal deletion" generally refers to a deletion that does not include the N-or C-terminus of a polypeptide or the 5 'or 3' end of a polynucleotide. Deletions (e.g., internal deletions) may be identified by comparison to a reference sequence, such as by specifying the start and end positions of the deletion relative to the reference sequence. Deletions (e.g., internal deletions) are different and distinct from substitutions. For example, a deletion of at least one amino acid does not be followed by insertion of at least one different amino acid at the same position as the at least one amino acid as compared to a reference polypeptide sequence, such that the size (e.g., number of amino acid residues) of a modified (or engineered) polypeptide sequence comprising the deletion of at least one amino acid is smaller than the size of the at least one amino acid that has been deleted compared to the reference polypeptide sequence.

The term "expression" generally refers to one or more processes of transcription from a DNA template into a polynucleotide (e.g., into mRNA or other RNA transcript), and/or to the subsequent translation of the transcribed mRNA into a peptide, polypeptide, or protein. Transcripts and encoded polypeptides may be collectively referred to as "gene products". If the polynucleotide is derived from genomic DNA, expression may include splicing of mRNA in eukaryotic cells. In terms of expression, "up-regulated" generally refers to an increase in the level of expression of a polynucleotide (e.g., RNA, such as mRNA) and/or polypeptide sequence relative to its level of expression in a wild-type state, and "down-regulated" generally refers to a decrease in the level of expression of a polynucleotide (e.g., RNA, such as mRNA) and/or polypeptide sequence relative to its level of expression in a wild-type state. Expression of the transfected gene may occur transiently or stably in the cell. During "transient expression", the transfected gene is not transferred to daughter cells during cell division. Since its expression is limited to transfected cells, the expression of the gene disappears over time. In contrast, stable expression of the transfected gene can occur when the gene is co-transfected with another gene that confers selective advantage on the transfected cell. Such a selection advantage may be resistance to a certain toxin presented to the cell.

The term "expression profile" generally refers to the quantitative (e.g., abundance) and qualitative expression of one or more genes in a sample (e.g., a cell). The one or more genes may be expressed and identified in the form of a nucleic acid molecule (e.g., mRNA or other RNA transcript). Alternatively or additionally, the one or more genes may be expressed and determined in the form of a polypeptide (e.g., a protein determined by western blotting). The expression profile of a gene may be defined as the shape of the level of expression of the gene over a period of time (e.g., at least or up to about 1 hour, at least or up to about 2 hours, at least or up to about 3 hours, at least or up to about 4 hours, at least or up to about 5 hours, at least or up to about 6 hours, at least or up to about 7 hours, at least or up to about 8 hours, at least or up to about 9 hours, at least or up to about 10 hours, at least or up to about 11 hours, at least or up to about 12 hours, at least or up to about 16 hours, at least or up to about 18 hours, at least or up to about 24 hours, at least or up to about 36 hours, at least or up to about 48 hours, at least or up to about 3 days, at least or up to about 4 days, at least or up to about 5 days, at least or up to about 6 days, at least or up to about 7 days, at least or up to about 8 days, at least or up to about 9 days, at least or up to about 10 days, at least or up to about 11 days, at least or up to about 12 days, at least or up to about 13 days, at least or up to about 14 days, etc.). Or the expression profile of a gene may be defined as the expression level of the gene at a time point of interest (e.g., the expression level of the gene measured after treatment of a cell to induce such expression level for at least or at most about 1 hour, at least or at most about 2 hours, at least or at most about 3 hours, at least or at most about 4 hours, at least or at most about 5 hours, at least or at most about 6 hours, at least or at most about 7 hours, at least or at most about 8 hours, at least or at most about 9 hours, at least or at most about 10 hours, at least or at most about 11 hours, at least or at most about 12 hours, at least or at most about 16 hours, at least or at most about 18 hours, at least or at most about 24 hours, at least or at most about 36 hours, at least or at most about 48 hours, at least or at most about 3 days, at least or at most about 4 days, at least or at most about 5 days, at least or at most about 6 days, at least or at most about 7 days, at least or at most about 8 days, at least or at least about 9 days, at least or at least about 10 days, at least or at least about 11 days, or at least about 13 days).

The terms "peptide", "polypeptide" or "protein" are used interchangeably herein to generally refer to a polymer of at least two amino acid residues joined by peptide bonds. The term does not imply a particular length of polymer nor is it intended to imply or distinguish whether the peptide is produced using recombinant techniques, chemical synthesis or enzymatic synthesis, or is naturally occurring. These terms apply to naturally occurring amino acid polymers and amino acid polymers comprising at least one modified amino acid. In some cases, the polymer may be interrupted by non-amino acids. These terms include amino acid chains of any length, including full-length proteins, as well as proteins with or without secondary and/or tertiary structures (e.g., domains). These terms also encompass modified amino acid polymers, for example, modified by disulfide bond formation, glycosylation, lipidation, acetylation, phosphorylation, oxidation, and any other manipulation (e.g., conjugation to a labeling element). As used herein, the terms "amino acid" and "amino acids" generally refer to natural and unnatural amino acids, including, but not limited to, modified amino acids and amino acid analogs. Modified amino acids may include natural amino acids and unnatural amino acids that have been chemically modified to include groups or chemical moieties on the amino acid that do not occur naturally. Amino acid analogs may refer to amino acid derivatives. The term "amino acid" includes D-amino acids and L-amino acids.

With respect to polypeptides, the terms "derivative," "variant," or "fragment" as used herein generally refer to polypeptides that are related to wild-type polypeptides, e.g., by amino acid sequence, structure (e.g., secondary structure and/or tertiary structure), activity (e.g., enzymatic activity), and/or function. Derivatives, variants, and fragments of the polypeptides may comprise one or more amino acid variations (e.g., mutations, insertions, and deletions), truncations, modifications, or combinations thereof, as compared to the wild-type polypeptide.

With respect to polypeptide molecules (e.g., proteins), the term "engineered," "chimeric," or "recombinant" as used herein generally refers to polypeptide molecules having a heterologous amino acid sequence or an altered amino acid sequence as a result of the application of genetic engineering techniques to the nucleic acid encoding the polypeptide molecule, as well as to the cell or organism in which the polypeptide molecule is expressed. With respect to polynucleotide molecules (e.g., DNA or RNA molecules), the term "engineered" or "recombinant" as used herein generally refers to polynucleotide molecules having a heterologous nucleic acid sequence or altered nucleic acid sequence as a result of the application of genetic engineering techniques. Genetic engineering techniques include, but are not limited to, PCR and DNA cloning techniques, transfection, transformation, and other gene transfer techniques, homologous recombination, site-directed mutagenesis, and gene fusion. In some cases, an engineered or recombinant polynucleotide (e.g., a genomic DNA sequence) may be modified or altered by a gene editing portion. For example, a heterologous endonuclease disclosed herein (e.g., an engineered Cas protein) is not a naturally occurring nuclease (e.g., is not a naturally occurring Cas protein). In another example, the engineered gene effector disclosed herein is not a naturally occurring gene effector.

For example, the engineered nucleases (e.g., engineered Cas proteins) disclosed herein are not naturally occurring nucleases (e.g., are not naturally occurring Cas proteins). The terms "engineered nuclease" and "engineered nuclease variant" are used interchangeably herein.

The terms "engineered" and "modified" are used interchangeably herein. The terms "engineering" and "modification" are used interchangeably herein. The terms "engineered cell" and "modified cell" are used interchangeably herein. The terms "engineered feature" and "modified feature" are used interchangeably herein.

The terms "enhancing expression," "increasing expression," or "up-regulating expression" generally refer to the production of a portion of interest (e.g., a polynucleotide or polypeptide) to a level that is higher than the normal expression level of the portion of interest in a host strain (e.g., host cell). The normal expression level may be substantially zero (or null) or above zero. The moiety of interest may comprise an endogenous gene or polypeptide construct of the host strain. The moiety of interest may comprise a heterologous gene or polypeptide construct introduced into or into the host strain. For example, a heterologous gene encoding a polypeptide of interest may be knocked-in (KI) to the genome of a host strain to enhance expression of the polypeptide of interest in the host strain.

The terms "enhancing activity", "increasing activity" or "upregulating activity" generally refer to the modification of the activity of a moiety of interest (e.g., a polynucleotide or polypeptide) to a level that is higher than the normal activity level of the moiety of interest in a host strain (e.g., host cell). The normal activity level may be substantially zero (or null) or above zero. The moiety of interest may comprise a polypeptide construct of the host strain. The moiety of interest may comprise a heterologous polypeptide construct introduced into or into the host strain. For example, a heterologous gene encoding a polypeptide of interest may be knocked-in (KI) to the genome of a host strain to enhance the activity of the polypeptide of interest in the host strain.

The terms "reduce expression," "reduce expression," or "downregulate expression" generally refer to the production of a portion of interest (e.g., a polynucleotide or polypeptide) to a level below the normal expression level of the portion of interest in a host strain (e.g., host cell). The normal expression level is above zero. The moiety of interest may comprise an endogenous gene or polypeptide construct of the host strain. In some cases, the moiety of interest may be knocked out or knocked down in the host strain. In some examples, reducing expression of the moiety of interest may include completely inhibiting such expression in the host strain.

The terms "decreasing activity", "reducing activity" or "down-regulating activity" generally refer to the modification of the activity of a moiety of interest (e.g., a polynucleotide or polypeptide) to a level below the normal activity level of the moiety of interest in a host strain (e.g., host cell). The normal activity level is above zero. The moiety of interest may comprise an endogenous gene or polypeptide construct of the host strain. In some cases, the moiety of interest may be knocked out or knocked down in the host strain. In some examples, the reduced activity of the moiety of interest may include completely inhibiting such activity in the host strain.

The terms "subject", "individual" or "patient" are used interchangeably herein to refer generally to a vertebrate, preferably a mammal, such as a human. Mammals include, but are not limited to, murine animals, apes, humans, domestic animals, sports animals, and pets. Tissues, cells, and their progeny of biological entities obtained in vivo or cultured in vitro are also contemplated.

The term "treatment" or "treatment" generally refers to a method of achieving a beneficial or desired result, including but not limited to a therapeutic benefit and/or a prophylactic benefit. For example, treatment may include administration of a system or cell population as disclosed herein. Therapeutic benefit refers to any treatment-related improvement or effect on one or more diseases, disorders or symptoms in treatment. For a prophylactic benefit, the composition may be administered to a subject at risk of developing a particular disease, disorder, or symptom, or to a subject reporting one or more physiological symptoms of the disease, even though the disease, disorder, or symptom may not have been manifested.

The term "effective amount" or "therapeutically effective amount" generally refers to an amount of a composition (e.g., a composition comprising a heterologous polypeptide, a heterologous polynucleotide, and/or a modified cell (e.g., a modified stem cell)) sufficient to produce a desired activity when administered to a subject in need thereof. In the context of the present disclosure, the term "therapeutically effective" generally refers to an amount of a composition sufficient to delay manifestation, prevent progression, alleviate or mitigate at least one symptom of a disorder treated by the methods of the present disclosure.

The term "at least," "greater than," or "greater than or equal to" when used in reference to a first value in a series of two or more values applies to each value in the series of values. For example, 1, 2, or 3 or more is equivalent to 1 or more, 2 or more, or 3 or more.

When the term "no more," "less than," or "less than or equal to" precedes the first value in a series of two or more values, the term "no more," "less than," or "less than or equal to" applies to each value in the series of values. For example, less than or equal to 3, 2, or 1 is equivalent to less than or equal to 3, less than or equal to 2, or less than or equal to 1.

The term "about" or "approximately" generally means within an acceptable error range for a particular value as determined by one of ordinary skill in the art, which will depend in part on how the value is measured or determined, i.e., the limitations of the measurement system. For example, "about" may mean within 1 or more than 1 standard deviation, as is conventional in the art. Or "about" may mean a range of no more than 20%, no more than 10%, no more than 5%, or no more than 1% of a given value. Or in particular for biological systems or processes, the term may mean within an order of magnitude of the value, preferably within a factor of 5, and more preferably within a factor of 2. In describing particular values in the present application and claims, the term "about" should be construed to mean within an acceptable error range for the particular value unless otherwise indicated.

The use of alternatives (e.g., "or") is understood to mean one, two, or any combination thereof. The term "and/or" is understood to mean one or both of the alternatives.

Engineered gene effector

In some aspects, the present disclosure provides compositions, combinations, systems, and methods that utilize engineered gene effectors. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-95 amino acids in length and a second peptide that is 75-95 amino acids in length, the second peptide being heterologous to the first peptide. In some embodiments, the engineered gene effector comprises a first peptide that is 75-95 amino acids in length and a second peptide that is 75-95 amino acids in length, the second peptide being heterologous to the first peptide, wherein the first peptide is different from the second peptide. In some embodiments, the first peptide and/or the second peptide is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length, or optionally, the first peptide and/or the second peptide is in a range defined by any two of the above lengths (e.g., 76-94, 77-93, 78-92, 79-91, 80-90, 82-98, etc.).

In some aspects, the present disclosure provides compositions, combinations, systems, and methods that utilize engineered gene effectors. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length, the second peptide being heterologous to the first peptide. In some embodiments, the engineered gene effector comprises a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length, the second peptide being heterologous to the first peptide, wherein the first peptide is different from the second peptide. In some embodiments, the first peptide and/or the second peptide is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109 amino acids in length, or optionally, the length is within a range defined by any two of the above lengths (e.g., 76-94, 77-93, 78-92, 79-91, 80-90, 82-98, 80-109, 85-108, etc.).

In some embodiments, the engineered gene effector of the present disclosure is capable of activating a target gene in a cell when expressed and effectively targeted to a site of the target gene in the cell. In some aspects, the present disclosure provides compositions, combinations, systems, and methods that utilize engineered gene effectors. In some embodiments, the engineered gene effector of the present disclosure comprises a polypeptide comprising a first peptide 75-95 (or 75-110) amino acids in length and a second peptide 75-95 (or 75-110) amino acids in length, the second peptide being heterologous to the first peptide, wherein the engineered gene effector is capable of activating a target gene in a cell when expressed in the cell and effectively targeted to a site of the target gene. In some embodiments, the first peptide and/or the second peptide is based on a human transcriptional regulator. In some embodiments, the first peptide and the second peptide are based on a human transcriptional regulator. In some embodiments, the first peptide and/or the second peptide is based on a viral transcriptional regulator. In some embodiments, the first peptide and the second peptide are based on a viral transcriptional regulator. In some embodiments, the first peptide is based on a human transcriptional regulator and the second peptide is based on a viral transcriptional regulator. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide is different from the second peptide in length. In some embodiments, the first peptide is the same length as the second peptide.

In some embodiments, the first peptide and/or the second peptide of the engineered gene effector has a beta factor of about 30 to about 65. In some embodiments, the first peptide has a beta factor of about 30, about 35, about 40, about 45, about 50, about 55, about 60, or about 65, optionally the beta factor of the first peptide is within a range defined by any two of the foregoing values (e.g., about 30 to about 40, about 35 to about 55, about 40 to about 65). In some embodiments, the second peptide has a beta factor of about 30, about 35, about 40, about 45, about 50, about 55, about 60, or about 65, optionally the beta factor of the second peptide is within a range defined by any two of the foregoing values (e.g., about 30 to about 40, about 35 to about 55, about 40 to about 65). In some embodiments, the engineered gene effector of the present disclosure comprises a first peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and a second peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length, wherein the first peptide and/or the second peptide has a beta factor of about 30, about 35, about 40, about 45, about 50, about 55, about 60, or about 65. In some embodiments, the engineered gene effectors of the present disclosure comprise a first peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and a second peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 94, or 95 amino acids in length, wherein the beta factor of the first peptide and/or the second peptide is within a range defined by any two of the foregoing values (e.g., about 30 to about 40, about 35 to about 55, about 40 to about 65).

In some embodiments, the first peptide and/or the second peptide of the engineered gene effector is enriched in a negative electrostatic potential. In some embodiments, the first peptide and the second peptide are enriched in a negative electrostatic potential. In some embodiments, the engineered gene effector comprises a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and a second peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, or 95 amino acids in length, wherein the first peptide and/or the second peptide is enriched in negative electrostatic potential. In some embodiments, the engineered gene effector comprises a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length and a second peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 88, 89, 90, 91 or 95 amino acids in length, wherein the first peptide is enriched in negative electrostatic potential and the second peptide is enriched in negative electrostatic potential.

In some embodiments, the first peptide and/or the second peptide of the engineered gene effector has a negative net charge. In some embodiments, the first peptide and the second peptide of the engineered gene effector have a negative net charge. In some embodiments, the engineered gene effector comprises a first peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and a second peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 94, or 95 amino acids in length, wherein the first peptide and/or the second peptide has a negative net charge. In some embodiments, the engineered gene effector comprises a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length and a second peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91 or 95 amino acids in length, wherein the first peptide has a negative net charge and the second peptide has a negative net charge.

TABLE 3 amino acid sequences of individual peptides

SEQ ID NO	Amino acid sequence
		1	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK
2	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE
		3	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT
4	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP
		5	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF
6	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN
		7	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ
8	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV
		9	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF
10	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS
		11	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL
12	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA
		13	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP
14	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP
		15	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL
16	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI
		17	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV
18	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN
		19	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG
20	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM
		21	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV
22	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR
		23	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF
24	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH
		25	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY
26	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY
		27	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG
28	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV
		29	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL
30	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ
		31	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN
32	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY
		33	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS
34	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL
		35	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK
36	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD
		37	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA
38	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL
		39	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK
40	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL
		41	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI
42	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS
		43	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP
44	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML
		45	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL
46	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ
		47	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS
48	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM
		49	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY
50	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH
		51	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV
52	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL
		53	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI
54	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL
		55	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE
56	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS
		57	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES
58	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER
		59	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN
60	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK
		61	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ
62	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP
		63	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV
64	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP
		65	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL
66	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE
		67	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT
68	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL
		69	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
70	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD
		71	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET
72	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR
		73	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF
74	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ
		75	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG
76	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL
		77	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR
78	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS
		79	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE
80	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD
		81	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN
82	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK
		83	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT
84	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS
		85	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL
86	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL
		87	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG
88	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL
		89	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL
90	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ
		91	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT
92	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD
		93	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV
94	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK
		95	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS
96	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA
		97	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS
98	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH
		99	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA
100	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising any one of the sequences provided in table 3 and a second peptide that is heterologous to the first peptide and comprises any one of the sequences provided in table 3. In some embodiments, the first peptide is 75-110 amino acids in length. In some embodiments, the second peptide is 75-110 amino acids in length. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising any one of SEQ ID NOS: 3-100 in length of 75-110 amino acids and a second peptide comprising any one of SEQ ID NOS: 3-100 in length of 75-110 amino acids, the second peptide being heterologous to the first peptide. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising any one of SEQ ID NOS 3-33 and 35-100 in length of 75-95 amino acids and a second peptide comprising any one of SEQ ID NOS 3-33 and 35-100 in length of 75-95 amino acids, the second peptide being heterologous to the first peptide. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length and a second peptide, the first peptide comprising any one of SEQ ID NOs 3-33 and 35-100 and the second peptide being 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length, the second peptide being heterologous to the first peptide and the second peptide comprising any one of SEQ ID NOs 3-33 and 35-100. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide is different from the second peptide in length. In some embodiments, the first peptide is the same length as the second peptide. In some embodiments, the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising a sequence that is, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any of the sequences provided in table 3 and a second peptide that is heterologous to the first peptide and comprises a sequence that is, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any of the sequences provided in table 3. In some embodiments, the first peptide comprises a sequence that is identical to any one of SEQ ID NOs 3-100 by, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, or optionally, the first peptide comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 3-100. In some embodiments, the second peptide comprises a sequence that is identical to any one of SEQ ID NOs 3-100 by, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, or optionally, the second peptide comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 3-100. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide has the above percentage of sequence identity to any one of SEQ ID NOS.3-100, which is different from the sequence of any one of SEQ ID NOS.3-100 having the above percentage of sequence identity to the second peptide. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

In some embodiments, the engineered gene effector comprises a first peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length and comprises a sequence that is about, or at most 85%, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95% identical to any of SEQ ID NOs 3-33 and 35-100, and a second peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length and comprises a sequence that is about, or at most 85%, 86, 87, 88, 89, 90, 96, 97, 98, 99% or 100% identical to any of SEQ ID NOs 3-33, 89, 90, 96, 97, 98%, 99% or at least one of the second peptide in length and at least about 85, 86, 96, 95% or at least 95% identical to any of SEQ ID NOs. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide has the above percentage of sequence identity to any one of SEQ ID NOS 3-33 and SEQ ID NOS 35-100, which is different from the sequence of any one of SEQ ID NOS 3-33 and SEQ ID NOS 35-100 having the above percentage of sequence identity to the second peptide. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide is different from the second peptide in length. In some embodiments, the first peptide is the same length as the second peptide. In some embodiments, the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

In some embodiments, the first peptide and/or the second peptide is 85 amino acids in length. In some embodiments, the first peptide and the second peptide are each 85 amino acids in length. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising any one of SEQ ID NOS 3-33 and 35-100 in length and a second peptide comprising any one of SEQ ID NOS 3-33 and 35-100 in length that is heterologous to the first peptide. In some embodiments, the first peptide is different from the second peptide. In some embodiments, the first peptide is 85 amino acids in length and comprises a sequence that is about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any one of SEQ ID NOS: 3-33, SEQ ID NOS: 35-100, or optionally the first peptide comprises a percentage of identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98% -100%, etc.). In some embodiments, the second peptide is 85 amino acids in length and comprises a sequence that is about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any one of SEQ ID NOs: 3-100, SEQ ID NOs: 35-100, or optionally the second peptide comprises a percentage identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98% -100%, etc.). In some embodiments, the engineered gene effector comprises a first peptide of 85 amino acids in length comprising a sequence that is about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any one of SEQ ID NOS 3-33, 35-100, and a second peptide of 85 amino acids in length, the second peptide being heterologous to the first peptide, the second peptide comprising a sequence that is 3-33, Any of SEQ ID NOs 35-100 have, about, at least or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical sequences. In some embodiments, the first peptide has a percentage of sequence identity as described above with any one of SEQ ID NOS 3-33, 35-100 that is different from the sequence of any one of SEQ ID NOS 3-33, 35-100 that has a percentage of sequence identity as described above with the second peptide. In some embodiments, the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

In some embodiments, the engineered gene effector comprises a first peptide that is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and comprises a sequence that is about, at least or up to 85%, 86, 87, 88, 89, 90, 91, 92, 93, 94, 96, 97, 98, 99, or 100% identical to any of SEQ ID NOs 3-33 and 35-100, and a second peptide that is heterologous to the first peptide and comprises a sequence that is about, at least or up to 85%, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100% identical to SEQ ID NO 34. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide 75-95 amino acids in length and having the sequence of any one of SEQ ID NOS: 3-33, SEQ ID NOS: 35-100 (which has 0, 1,2, or 3 amino acid residue mutations), and a second peptide heterologous to the first peptide and having the sequence of SEQ ID NO: 34 (which has 0, 1,2, or 3 amino acid residue mutations). In some embodiments, the amino acid residue is mutated to a conservative substitution. In some embodiments, the engineered gene effector comprises a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and comprises the sequence of any one of SEQ ID NOs 3-33 and 35-100, and a second peptide heterologous to the first peptide and comprising the sequence of SEQ ID NO 34. In some embodiments, the engineered gene effector comprises a first peptide that is 85 amino acids in length and comprises the sequence of any one of SEQ ID NOS: 3-33 and SEQ ID NOS: 35-100, and a second peptide that is heterologous to the first peptide and comprises the sequence of SEQ ID NO: 34. In some embodiments, the first peptide is located at the N-terminus of the second peptide. In some embodiments, the second peptide is located at the N-terminus of the first peptide.

In some embodiments, the first peptide comprises the sequence of any one of SEQ ID NOs 3-100, having 0, 1,2 or 3 amino acid residue mutations. In some embodiments, the second peptide comprises the sequence of any one of SEQ ID NOs 3-100, having 0, 1,2 or 3 amino acid residue mutations. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide of 75-110 amino acids in length and having the sequence of any one of SEQ ID NOS: 3-33, 35-100 (having 0, 1, 2, or 3 amino acid residue mutations), and a second peptide of 75-110 amino acids in length, the second peptide being heterologous to the first peptide and having any one of SEQ ID NOS: 3-100 (having 0, 1, 2, or 3 amino acid residue mutations). In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and having the sequence of any one of SEQ ID NOs 3-33, 35-100 (having 0, 1,2, or 3 amino acid residue mutations), and a second peptide 75, a polypeptide comprising a sequence of any one of SEQ ID NOs 3-33, 35-100, and a polypeptide comprising a sequence of any one of SEQ ID NOs, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids, said second peptide being heterologous to the first peptide and having any one of SEQ ID NOs 3-33, 35-100 (which has 0, 1,2 or 3 amino acid residue mutations). in some embodiments, the amino acid residue is mutated to a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and comprising any one of SEQ ID NOs 3-33, 35-100 (having a mutation of 0,1, 2, or 3 amino acid residues), and a second peptide, wherein any mutation thereof is a conservative substitution, and the second peptide is 75, in length, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids, said second peptide being heterologous to the first peptide and comprising any one of SEQ ID NOs 3-33, 35-100 (having 0,1, 2 or 3 amino acid residue mutations), wherein any mutation thereof is a conservative substitution. In some embodiments, the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

The first polypeptide and the second polypeptide may be in any suitable position relative to each other in the polypeptides. In some embodiments, the first peptide is located N-terminal to the second peptide in the polypeptide. In some embodiments, the second peptide is located N-terminal to the first peptide in the polypeptide. In some embodiments, the first peptide at the N-terminus of the second peptide comprises any one of SEQ ID NOS: 3-100, and the second peptide comprises any one of SEQ ID NOS: 3-100. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide comprises any one of SEQ ID NOs 3-100 and the second peptide is 75-110 amino acids in length, the second peptide being heterologous to the first peptide and the second peptide comprising any one of SEQ ID NOs 3-100. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide comprising any one of SEQ ID NOs 3-33, 35-100 and a second peptide comprising any one of SEQ ID NOs 3-35-100, the second peptide being 75, 76, 77, 78, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length, wherein the first peptide is 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 or 95 amino acids in length, and the second peptide is heterologous to the first peptide, wherein the second peptide comprises any one of SEQ ID NOs 3-33, 35-100. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, the first peptide being N-terminal to the second peptide, wherein the first peptide is 85 amino acids in length, the first peptide comprises any one of SEQ ID NOS: 3-33, SEQ ID NOS: 35-100, the second peptide is 85 amino acids in length, and the second peptide is heterologous to the first peptide and comprises any one of SEQ ID NOS: 3-33, SEQ ID NOS: 35-100.

In some embodiments, the first peptide is located N-terminal to the second peptide in the polypeptide, and the first peptide and the second peptide are selected according to any one of the pair-wise arrangements of SEQ ID NOs of the first peptide and the second peptide listed in table 4. In some embodiments, the engineered gene effector comprises a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length, and wherein the sequences of the first peptide and the second peptide are selected according to any one of the SEQ ID NOs listed in table 4 in a paired arrangement of the SEQ ID NOs of the first peptide and the second peptide. In some embodiments, the engineered gene effector comprises a first peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 amino acids in length and a second peptide 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 94, or 95 amino acids in length, and wherein the sequences of the first peptide and the second peptide are selected according to any of the SEQ ID NOs in the pairwise arrangement of SEQ ID NOs of the first peptide and the second peptide listed in table 4. In some embodiments, the engineered gene effector comprises a first peptide that is 85 or 108 amino acids in length and a second peptide that is 85 or 108 amino acids in length, and wherein the sequences of the first peptide and the second peptide are selected according to any one of the pairwise permutations of SEQ ID NOs of the first peptide and the second peptide listed in table 4.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, the first peptide being located N-terminally to the second peptide, wherein the first peptide comprises a sequence that is identical to any one of SEQ ID No. 75, SEQ ID No. 4, SEQ ID No. 40, and SEQ ID No. 77, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally the first peptide comprises a sequence that is identical to any one of SEQ ID No. 75, SEQ ID No. 4, SEQ ID No. 40, and SEQ ID No. 77, having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), and the second peptide comprises a sequence that is identical to any one of SEQ ID No. 64, SEQ ID No. 44, SEQ ID No. 77, SEQ ID No. 17, 96%, at least about, 86%, 98%, 99%, or 100%, or any one of SEQ ID No. 75, 4, 40, and 77, having a percent identity within a range defined by any two of the foregoing values (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), and the second peptide comprises a sequence that is identical to any one of SEQ ID No. 64, SEQ ID No. 17, 96%, at least about, at least one of the sequence that is identical to any one of the two of the foregoing values, or at least one of the sequence, which is defined by any one of SEQ ID No. 95%, or by any of the sequence 98% -100%, etc.). In some embodiments, the first peptide comprises the sequence of any one of SEQ ID NO. 75, SEQ ID NO. 4, SEQ ID NO. 40, and SEQ ID NO. 77, and the second peptide comprises the sequence of any one of SEQ ID NO. 64, SEQ ID NO. 44, SEQ ID NO. 77, SEQ ID NO. 17, and SEQ ID NO. 96.

In some embodiments, the engineered gene effector comprises a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide and the second peptide are selected according to any one of the pair-wise arrangements of SEQ ID NOs of the first peptide and the second peptide listed in table a. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

TABLE A non-limiting examples of engineered Gene effector peptide combinations

A ID	B ID	Bar code	The combined peptide SEQ ID NO:	the first peptide SEQ ID NO:	A second peptide SEQ ID NO:
						hvTR_P10541	XV1.2	TGCCAGACGGTC _A_Concatenation GAGATTGTGTCC _B	1085	75	64
hvTR_G3G929	XV1.32	CTCACGACAAGA _A_Concatenation ATAACTCCACGC _B	122	4	44
						hvTR_P10541	hvTR_Q2HR73	TGCCAGACGGTC _A_Concatenation ACTTGATGGTTT _B	1084	75	77
cds_NC_025350.1_cds_YP_009094074.1_1	LEUTX	ATGACAAAACGA _A_Concatenation ATGACCCCTTGT _B	653	40	17
						hvTR_Q2HR73	PRDM10	ACTTGATGGTTT _A_Concatenation AATCGATCCTAC _B	1099	77	96
hvTR_Q2HR73	XV1.2	ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	1107	77	64

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 75, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, a first peptide comprising a sequence that is identical to SEQ ID NO: 75 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values, and a second peptide comprising a sequence that is identical to SEQ ID NO: 64 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), or alternatively, a second peptide comprising a sequence that is identical to SEQ ID NO: 64 by a percentage (e.g., 85% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values. In some embodiments, the first peptide comprises the sequence of SEQ ID NO. 75 and the second peptide comprises the sequence of SEQ ID NO. 64. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 4, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, or optionally, the first peptide comprises a sequence that is identical to SEQ ID NO: 4 by a percentage of identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values, and a second peptide comprising a sequence that is identical to SEQ ID NO: 44 by a percentage of identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), said second peptide comprising a sequence that is identical to SEQ ID NO: 44 by a percentage of identity (e.g., 85% -100%, 95% -100%, 98% -100%, etc.), or optionally, the second peptide comprises a sequence that is identical to SEQ ID NO: 44 by a percentage of identity within a range defined by any two of the foregoing values. In some embodiments, the first peptide comprises the sequence of SEQ ID NO. 4 and the second peptide comprises the sequence of SEQ ID NO. 44. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 75, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, a first peptide comprising a sequence that is identical to SEQ ID NO: 75 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values, and a second peptide comprising a sequence that is identical to SEQ ID NO: 77 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), or alternatively, a second peptide comprising a sequence that is identical to SEQ ID NO: 77 by a percentage (e.g., 85% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values. In some embodiments, the first peptide comprises the sequence of SEQ ID NO. 75 and the second peptide comprises the sequence of SEQ ID NO. 77. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 40, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, or optionally, a first peptide comprising a sequence that is identical to SEQ ID NO: 40 by a percentage of identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range of any two of the foregoing values, and a second peptide comprising a sequence that is identical to SEQ ID NO: 17 by a percentage of identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), said second peptide comprising a sequence that is identical to SEQ ID NO: 17, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, or optionally, a second peptide comprising a sequence that is identical to SEQ ID NO: 17 within a range of any two of the foregoing values. In some embodiments, the first peptide comprises the sequence of SEQ ID NO. 40 and the second peptide comprises the sequence of SEQ ID NO. 17. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 77, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, a first peptide comprising a sequence that is identical to SEQ ID NO: 77 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values, and a second peptide comprising a sequence that is identical to SEQ ID NO: 96 by a percentage (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.), about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the second peptide comprises a percentage (e.g., 98% -100% identical to SEQ ID NO: 96 within a range defined by any two of the foregoing values. In some embodiments, the first peptide comprises the sequence of SEQ ID NO: 77 and the second peptide comprises the sequence of SEQ ID NO: 96. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

In some embodiments, the engineered gene effector comprises a first peptide comprising a sequence that is identical to SEQ ID NO: 77, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, a first peptide comprising a sequence that is identical to SEQ ID NO: 77, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 97%, 98%, 99%, or 100%, or optionally, a second peptide comprising a sequence that is identical to SEQ ID NO: 64, about, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, a second peptide comprising a sequence that is identical to SEQ ID NO: 64, within a range defined by any two of the foregoing values (e.g., 85% -100%, 90% -100%, 98% -100%, etc.). In some embodiments, the first peptide comprises the sequence of SEQ ID NO. 77 and the second peptide comprises the sequence of SEQ ID NO. 64. In some embodiments, the first peptide is linked to the second peptide through a linker. In some embodiments, the linker comprises the sequence of any one of SEQ ID NOS 2211-2221. In some embodiments, the linker comprises the sequence of SEQ ID NO 2211.

The first peptide and the second peptide in the engineered gene effector polypeptide may be linked to each other directly or indirectly (e.g., through a spacer or linker). In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, wherein the first peptide and the second peptide are linked by a spacer (e.g., a peptide spacer). Any suitable spacer may be used. In some embodiments, the spacer (e.g., peptide spacer) is a flexible linker having a sequence comprising fragments of glycine and serine residues. The small size of glycine and serine residues provides flexibility and allows fluidity of the linked functional domains. In some embodiments, the introduction of serine or threonine can maintain the stability of the spacer (e.g., peptide spacer) or linker in aqueous solution by forming hydrogen bonds with water molecules, thereby reducing adverse interactions between the spacer or linker and the attached moiety. In some embodiments, the flexible spacer or linker may also contain additional amino acids (e.g., threonine and alanine) to maintain flexibility, as well as polar amino acids (e.g., lysine and glutamine) to increase solubility. The rigid spacer or linker may have, for example, an alpha-helical structure. The alpha-helical stiff spacer or linker may act as a spacer between protein domains. Non-limiting examples of spacers or linkers include the sequences in table 5 and repeats thereof, e.g., 1, 2, 3, 4,5, 6, 7, 8, 9, or 10 repeats. SEQ ID NOS 2211-2217 provide flexible spacers or linkers or subunits thereof. SEQ ID NO 2218-2221 provides a rigid spacer or linker or subunit thereof. In some embodiments, the spacer (e.g., peptide spacer) or linker is SEQ ID NO: 2211 or comprises SEQ ID NO: 2211.

TABLE 5 linker amino acid sequence

SEQ ID NO:	Sequence(s)
		2211	GSGGSGGSGGSG
2212	GGGGS
		2213	GGGS
2214	GG
		2215	KESGSVSSEQLAQFRSLD
2216	EGKSSGSGSESKST
		2217	GSAGSAAGSGEF
2218	EAAAK
		2219	EAAAR
2220	PAPAP
		2221	AEAAAKEAAAKA

In some embodiments, the length of a spacer (e.g., a peptide spacer) or linker disclosed herein can be, for example, 1, 2, 3, 4, 5, 6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 amino acid residues.

In some embodiments, a spacer (e.g., a peptide spacer) or linker disclosed herein can comprise at least 1, at least 2, at least 3, at least 5, at least 7, at least 9, at least 11, at least 13, at least 15, or at least 20 amino acids. In some embodiments, a linker may comprise up to 5, up to 7, up to 9, up to 11, up to 13, up to 15, up to 20, up to 25, up to 30, up to 40, or up to 50 amino acids.

In some embodiments, the spacer (e.g., peptide spacer) or linker comprises up to about 20, up to about 15, up to about 14, up to about 13, up to about 12, up to about 11, up to about 10, up to about 9, up to about 8, up to about 7, up to about 6, up to about 5, up to about 4, up to about 3, up to about 2, or about 1 glycine-serine (GS) linkers. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising up to about 20, up to about 15, up to about 14, up to about 13, up to about 12, up to about 11, up to about 10, up to about 9, up to about 8, up to about 7, up to about 6, up to about 5, up to about 4, up to about 3, up to about 2, or about 1 glycine-serine (GS) linkers. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising at least about 1, at least about 2, at least about 3, at least about 4, at least about 5, at least about 6, at least about 7, at least about 9, at least about 10, at least about 11, at least about 12, at least about 13, at least about 14, at least about 15, at least about 20, or more GS linkers.

In some embodiments, the spacer (e.g., peptide spacer) or linker comprises up to about 20, up to about 15, up to about 14, up to about 13, up to about 12, up to about 11, up to about 10, up to about 9, up to about 8, up to about 7, up to about 6, up to about 5, up to about 4, up to about 3, up to about 2, or about 1 glycine (G) linkers. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising at least about 1, at least about 2, at least about 3, at least about 4, at least about 5, at least about 6, at least about 7, at least about 9, at least about 10, at least about 11, at least about 12, at least about 13, at least about 14, at least about 15, at least about 20, or more G linkers. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising up to about 20, up to about 15, up to about 14, up to about 13, up to about 12, up to about 11, up to about 10, up to about 9, up to about 8, up to about 7, up to about 6, up to about 5, up to about 4, up to about 3, up to about 2, or about 1 glycine (G) linkers. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising at least about 1, at least about 2, at least about 3, at least about 4, at least about 5, at least about 6, at least about 7, at least about 9, at least about 10, at least about 11, at least about 12, at least about 13, at least about 14, at least about 15, at least about 20, or more G linkers.

In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising any one of SEQ ID NOs 2211-2221, or a sequence thereof having 1-3 mutations. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide linked by a spacer (e.g., a peptide spacer) or linker comprising the sequence of SEQ ID NO 2211, or a sequence having 1-3 mutations thereof.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, the first peptide being N-terminal to the second peptide, wherein the first peptide comprises any one of SEQ ID NOs 3-100 in length and the second peptide is 85 or 108 amino acids in length, the second peptide being heterologous to the first peptide and comprising any one of SEQ ID NOs 3-100, wherein the SEQ ID NOs of the first peptide and the second peptide are selected according to any one of the pairwise arrangements of SEQ ID NOs of the first peptide and the second peptide listed in table 4, wherein the first peptide and the second peptide are linked by a spacer (e.g., a peptide spacer) or linker (e.g., a peptide linker). In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide and a second peptide, the first peptide being N-terminal to the second peptide, wherein the first peptide comprises any one of SEQ ID NOs 3-33, 35-100 in length and the second peptide is 85 amino acids in length, the second peptide being heterologous to the first peptide and comprising any one of SEQ ID NOs 3-33, 35-100, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of table 4 in a pairwise arrangement, wherein the first and second peptides are linked by a spacer (e.g., a peptide spacer) or linker (e.g., a peptide linker). In some embodiments, the linker is selected from any one of SEQ ID NOS 2211-2221. In some embodiments, the spacer (e.g., peptide spacer) or linker is SEQ ID NO: 2211. In some embodiments, a non-peptide spacer or linker is used. The non-peptide spacer or linker may be, for example, a chemical linker. The two parts of the complex of the present disclosure may be joined by a chemical linker. Each chemical linker of the present disclosure may be alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene, any of which may be optionally substituted. In some embodiments, the chemical linker of the present disclosure may be an ester, ether, amide, thioether, or polyethylene glycol (PEG). In some embodiments, the spacer or linker may reverse the order of amino acid sequences in the compound, e.g., such that the amino acid sequences linked by the linker are head-to-head, rather than head-to-tail. Non-limiting examples of such spacers or linkers include dicarboxylic acid diesters, such as oxalyl diester, malonyl diester, succinyl diester glutaryl diester, adipoyl diester, pimeloyl diester fumaroyl diester, maleoyl diester, phthaloyl diester, isophthaloyl diester, or terephthaloyl diester. Non-limiting examples of such spacers or linkers include dicarboxylic acid diamides such as oxalamide, malonyl diamide, succinyl diamide, glutaryl diamide, adipoyl diamide, pimeloyl diamide, fumaryl diamide, maleyl diamide, phthaloyl diamide, isophthaloyl diamide, or terephthaloyl diamide. Non-limiting examples of such spacers or linkers include diamides of diamino linkers such as ethylenediamine, 1, 2-di (methylamino) ethane, 1, 3-diaminopropane, 1, 3-di (methylamino) propane, 1, 4-di (methylamino) butane, 1, 5-di (methylamino) pentane, 1, 6-di (methylamino) hexane, and piperazine. Non-limiting examples of optional substituents include hydroxy, mercapto, halogen, amino, nitro, nitroso, cyano, azido, sulfoxide, sulfone, sulfonamide, carboxyl, carboxyaldehyde, imine, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, aryl, aryloxy, arylalkyl, arylalkoxy, heterocyclyl, acyl, acyloxy, carbamate, amide, ureido, epoxy, or ester.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or, optionally, a polypeptide comprising a sequence that has a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence having a mutation of 0,1, 2, or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, or optionally, the first peptide comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, having a mutation of 0, 1, 2, or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107. In some embodiments, the engineered gene effector consists of a polypeptide having any one of the sequences of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, or optionally, the first peptide comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequences of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, having 0, 1,2, or 3 amino acid residue mutations. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequences of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107. In some embodiments, the engineered gene effector consists of a polypeptide having the sequences of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107. In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is identical to SEQ ID No. 1085, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the first peptide comprises a sequence that is within a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) to any two of the foregoing defined values of SEQ ID No. 1085. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO: 1085 with a mutation of 0, 1,2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1085. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO: 1085.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID No. 122, or optionally, the first peptide comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to SEQ ID No. 122. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 122 having a mutation of 0, 1,2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 122. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO. 122.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is identical to SEQ ID No. 1084, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the first peptide comprises a sequence that is within a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) to any two of the foregoing defined values of SEQ ID No. 1084. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO: 1085 with a mutation of 0, 1, 2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1084. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO: 1084.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is identical to SEQ ID No. 653, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the first peptide comprises a sequence that is within a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to SEQ ID No. 653. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 653 with a mutation of 0, 1, 2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 653. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO. 653.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is identical to, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID No. 1099, or optionally, the first peptide comprises a sequence that is within a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) to any two of the foregoing values of SEQ ID No. 1099. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1099 having a mutation of 0, 1, 2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1099. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO. 1099.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a sequence that is identical to, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID No. 1107, or optionally, the first peptide comprises a sequence that has a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to SEQ ID No. 1107. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1107 with mutations of 0, 1, 2 or 3 amino acid residues. In some embodiments, the mutation is a conservative substitution. In some embodiments, the engineered gene effector comprises a polypeptide comprising the sequence of SEQ ID NO. 1107. In some embodiments, the engineered gene effector consists of a polypeptide having the sequence of SEQ ID NO: 1107.

In some embodiments, the engineered gene effector is capable of activating a target gene in a cell when expressed in the cell and effectively targeted to a site of the target gene (e.g., along with a heterologous endonuclease). In some embodiments, the target gene is endogenous to the cell. In some embodiments, the target gene is a silenced gene, optionally, wherein the silenced gene is a methylated gene. In some embodiments, the engineered gene effector is capable of repressing a target gene in a cell when expressed in the cell and effectively targeted to a site of the target gene.

The target gene may be any suitable gene. For example, without limitation, the target gene may be any one of the genes listed in table 6.

In some embodiments, the engineered gene effector (e.g., together with the heterologous endonuclease) is capable of increasing, about or increasing by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 250%, 300%, 400%, 500% or more the expression level of the target gene, or optionally, the engineered gene effector is capable of increasing the expression level of the target gene by a percentage (e.g., 10% -100%, 100% -200%, 200% -400%, 250% -500%, 10% -50% or 50% -100%, etc.) within a range defined by any two of the foregoing values. In some embodiments, the engineered gene effector (e.g., together with the heterologous endonuclease) is capable of increasing the expression level of the target gene by at least or about 10%, at least or about 20%, at least or about 30%, at least or about 40%, at least or about 50%, at least or about 60%, at least or about 70%, at least or about 80%, at least or about 90%, at least or about 100%, at least or about 200%, at least or about 250%, at least or about 300%, at least or about 400%, or at least or about 500%.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length, the second peptide being heterologous to the first peptide, wherein the engineered gene effector is capable of activating a synthetic reporter gene in a cell (e.g., along with a heterologous endonuclease described herein) at least or about 1, At least or about 2, at least or about 3, at least or about 4, at least or about 5, at least or about 6, at least or about 7, at least or about 8, at least or about 9, at least or about 10, at least or about 11, at least or about 12, at least or about 13, at least or about 14, at least or about 15, or at least or about 16, optionally, activating (e.g., as a log2 fold change) within a range defined by any two of the foregoing values (e.g., about 1 to about 5, about 1 to about 3, about 3 to about 5, about 2 to about 4, about 1 to about 15, about 1 to about 10, about 5 to about 10, about 10 to about 15). In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-95 amino acids in length and a second peptide that is 75-95 amino acids in length, the second peptide being heterologous to the first peptide, wherein the engineered gene effector is capable of activating a synthetic reporter gene in a cell (e.g., along with a heterologous endonuclease described herein) at least or about 1, At least or about 2, at least or about 3, at least or about 4, at least or about 5, at least or about 6, at least or about 7, at least or about 8, at least or about 9, at least or about 10, at least or about 11, at least or about 12, at least or about 13, at least or about 14, at least or about 15, or at least or about 16, optionally, activating (e.g., as a log2 fold change) within a range defined by any two of the foregoing values (e.g., about 1 to about 5, about 1 to about 3, about 3 to about 5, about 2 to about 4, about 1 to about 15, about 1 to about 10, about 5 to about 10, about 10 to about 15). In some embodiments, the engineered gene effector comprises a first peptide that is 85 or 108 amino acids in length and a second peptide that is 85 or 108 amino acids in length, wherein the sequences of the first peptide and the second peptide are selected according to any one of the pairwise permutations of SEQ ID NOs of the first peptide and the second peptide listed in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 1 (e.g., expressed as a log2 fold change), wherein the combination of the SEQ ID NOs of the engineered gene effector first peptide and the second peptide in table 9 is determined in table 4 based on the barcodes, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcodes. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 2 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 3 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 4 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 5 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 6 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 7 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 8 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 9 that activates a synthetic reporter gene (e.g., with a heterologous endonuclease described herein) in a cell at an activation level of at least 9 (e.g., expressed as a log2 fold change), wherein the combination of the first peptide and the second peptide of the engineered gene effector in table 9 is determined in table 4 based on a barcode, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on the combination determined in table 4 based on the barcode. In some embodiments, the first peptide and the second peptide are linked by a spacer (e.g., a peptide spacer such as, but not limited to, a spacer of any of SEQ ID NOS: 2211-2221, optionally a spacer of SEQ ID NO: 2211). In some embodiments, the engineered gene effector having any of the above-described activation levels of a synthetic reporter gene in a cell is selected from the group consisting of ：SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451.

In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length, the second peptide being heterologous to the first peptide, wherein the engineered gene effector is capable of activating an endogenous CD45 gene in a cell (e.g., along with a heterologous endonuclease described herein) at least or about 1, At least or about 2, at least or about 3, at least or about 4, at least or about 5, at least or about 6, at least or about 7, at least or about 8, at least or about 9, at least or about 10, at least or about 11, at least or about 12, at least or about 13, at least or about 14, at least or about 15, or at least or about 16, optionally, activating (e.g., as a log2 fold change) within a range defined by any two of the foregoing values (e.g., about 1 to about 5, about 1 to about 3, about 3 to about 5, about 2 to about 4, about 1 to about 15, about 1 to about 10, about 5 to about 10, about 10 to about 15). In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-95 amino acids in length and a second peptide that is 75-95 amino acids in length, the second peptide being heterologous to the first peptide, wherein the engineered gene effector is capable of activating an endogenous CD45 gene in a cell (e.g., along with a heterologous endonuclease described herein) at least or about 1, At least or about 2, at least or about 3, at least or about 4, at least or about 5, at least or about 6, at least or about 7, at least or about 8, at least or about 9, at least or about 10, at least or about 11, at least or about 12, at least or about 13, at least or about 14, at least or about 15, or at least or about 16, optionally, activating (e.g., as a log2 fold change) within a range defined by any two of the foregoing values (e.g., about 1 to about 5, about 1 to about 3, about 3 to about 5, about 2 to about 4, about 1 to about 15, about 1 to about 10, about 5 to about 10, about 10 to about 15). In some embodiments, the engineered gene effector comprises a first peptide that is 85 or 108 amino acids in length and a second peptide that is 85 or 108 amino acids in length, wherein the sequences of the first peptide and the second peptide are selected according to any one of the pairwise permutations of SEQ ID NOs of the first peptide and the second peptide listed in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 1 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 2 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 3 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 4 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 5 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 6 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 7 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 8 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level (e.g., expressed as a log2 fold change) of at least 9, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level (e.g., expressed as a log2 fold change) of at least 10, optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the engineered gene effector comprises a polypeptide comprising a first peptide that is 75-110 amino acids in length and a second peptide that is 75-110 amino acids in length and that is heterologous to the first peptide, wherein the first peptide and the second peptide are any one of the engineered gene effectors provided in table 10 that activates an endogenous CD45 gene (e.g., along with a heterologous endonuclease described herein) in a cell at an activation level of at least 11 (e.g., expressed as a log2 fold change), optionally wherein the engineered gene effector comprises a peptide amino acid sequence based on a combination of barcodes as determined in table 4. In some embodiments, the first peptide and the second peptide are linked by a spacer (e.g., a peptide spacer such as, but not limited to, a spacer of any of SEQ ID NOS: 2211-2221, optionally a spacer of SEQ ID NO: 2211). In some embodiments, the engineered gene effector having any of the above-described activation levels of the endogenous CD45 gene in the cell is selected from the group consisting of ：SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451.

TABLE 4 combined peptide amino acid sequences

Bar code	Combination peptide SEQ ID NO	Combined peptide amino acid sequences	First peptide SEQ ID NO	Linker SEQ ID NO	Second peptide SEQ ID NO
						Stop-1_A/u splice_ GAGATTGTGTCC _b	101	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	1	2211	64
Stop-1_A/u splice_ ACTTGATGGTTT _b	102	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	1	2211	77
						Stop-1_A/u splice_ CTACGTGGCCCC _b	103	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	1	2211	86
Stop-1_A/u splice_ ATGACCCCTTGT _b	104	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	1	2211	17
						Stop-1_A/u splice_ AGAGTGCGCTCT _b	105	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	1	2211	14
Stop-1_A/u splice_ ATAACTCCACGC _b	106	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	1	2211	44
						Stop-1_A/u splice_ CCCTATGTTCTA _b	107	***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	1	2211	15
Stop 2_A splice ATGACCCCTTGT B	108	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	2	2211	17
						Stop 2_A splice ATAACTCCACGC B	109	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	2	2211	44
Stop 2_A splice ACTTGATGGTTT B	110	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	2	2211	77
						Stop 2_A splice AGAGTGCGCTCT B	111	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	2	2211	14
Stop 2_A splice CTACGTGGCCCC B	112	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	2	2211	86
						Stop 2_A splice GAGATTGTGTCC B	113	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	2	2211	64
Stop 2_A splice CCCTATGTTCTA B	114	***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLEGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	2	2211	15
						CAGTGACATAGT _A_Concatenation ACTTGATGGTTT _B	115	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	3	2211	77
CAGTGACATAGT _A_Concatenation AGAGTGCGCTCT _B	116	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	3	2211	14
						CAGTGACATAGT _A_Concatenation CTACGTGGCCCC _B	117	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	3	2211	86
CAGTGACATAGT _A_Concatenation ATAACTCCACGC _B	118	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	3	2211	44
						CAGTGACATAGT _A_Concatenation GAGATTGTGTCC _B	119	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	3	2211	64
CAGTGACATAGT _A_Concatenation ATGACCCCTTGT _B	120	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	3	2211	17
						CAGTGACATAGT _A_Concatenation CCCTATGTTCTA _B	121	AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	3	2211	15
CTCACGACAAGA _A_Concatenation ATAACTCCACGC _B	122	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	4	2211	44
						CTCACGACAAGA _A_Concatenation CTACGTGGCCCC _B	123	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	4	2211	86
CTCACGACAAGA _A_Concatenation ATGACCCCTTGT _B	124	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	4	2211	17
						CTCACGACAAGA _A_Concatenation GAGATTGTGTCC _B	125	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	4	2211	64
CTCACGACAAGA _A_Concatenation ACTTGATGGTTT _B	126	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	4	2211	77
						CTCACGACAAGA _A_Concatenation AGAGTGCGCTCT _B	127	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	4	2211	14
CTCACGACAAGA _A_Concatenation CCCTATGTTCTA _B	128	ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	4	2211	15
						CATTAGTCCCGC _A_Concatenation CTACGTGGCCCC _B	129	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	5	2211	86
CATTAGTCCCGC _A_Concatenation ATAACTCCACGC _B	130	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	5	2211	44
						CATTAGTCCCGC _A_Concatenation AGAGTGCGCTCT _B	131	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	5	2211	14
CATTAGTCCCGC _A_Concatenation ATGACCCCTTGT _B	132	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	5	2211	17
						CATTAGTCCCGC _A_Concatenation GAGATTGTGTCC _B	133	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	5	2211	64
CATTAGTCCCGC _A_Concatenation ACTTGATGGTTT _B	134	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	5	2211	77
						CATTAGTCCCGC _A_Concatenation CCCTATGTTCTA _B	135	AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEFGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	5	2211	15
CTCGCACCGAGG _A_Concatenation ACTTGATGGTTT _B	136	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	6	2211	77
						CTCGCACCGAGG _A_Concatenation ATGACCCCTTGT _B	137	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	6	2211	17
CTCGCACCGAGG _A_Concatenation ATAACTCCACGC _B	138	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	6	2211	44
						CTCGCACCGAGG _A_Concatenation GAGATTGTGTCC _B	139	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	6	2211	64
CTCGCACCGAGG _A_Concatenation AGAGTGCGCTCT _B	140	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	6	2211	14
						CTCGCACCGAGG _A_Concatenation CTACGTGGCCCC _B	141	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	6	2211	86
CTCGCACCGAGG _A_Concatenation CCCTATGTTCTA _B	142	AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNNGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	6	2211	15
						AAACTTTGAGCG _A_Concatenation ATGACCCCTTGT _B	143	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	7	2211	17
AAACTTTGAGCG _A_Concatenation CTACGTGGCCCC _B	144	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	7	2211	86
						AAACTTTGAGCG _A_Concatenation GAGATTGTGTCC _B	145	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	7	2211	64
AAACTTTGAGCG _A_Concatenation ACTTGATGGTTT _B	146	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	7	2211	77
						AAACTTTGAGCG _A_Concatenation AGAGTGCGCTCT _B	147	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	7	2211	14
AAACTTTGAGCG _A_Concatenation ATAACTCCACGC _B	148	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	7	2211	44
						AAACTTTGAGCG _A_Concatenation CCCTATGTTCTA _B	149	AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	7	2211	15
CATTGTTTAAAT _A_Concatenation CTACGTGGCCCC _B	150	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	8	2211	86
						CATTGTTTAAAT _A_Concatenation GAGATTGTGTCC _B	151	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	8	2211	64
CATTGTTTAAAT _A_Concatenation AGAGTGCGCTCT _B	152	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	8	2211	14
						CATTGTTTAAAT _A_Concatenation ATAACTCCACGC _B	153	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	8	2211	44
CATTGTTTAAAT _A_Concatenation ACTTGATGGTTT _B	154	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	8	2211	77
						CATTGTTTAAAT _A_Concatenation ATGACCCCTTGT _B	155	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	8	2211	17
CATTGTTTAAAT _A_Concatenation CCCTATGTTCTA _B	156	AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	8	2211	15
						CTCGTTATGGCA _A_Concatenation AGAGTGCGCTCT _B	157	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	9	2211	14
CTCGTTATGGCA _A_Concatenation ATAACTCCACGC _B	158	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	9	2211	44
						CTCGTTATGGCA _A_Concatenation CTACGTGGCCCC _B	159	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	9	2211	86
CTCGTTATGGCA _A_Concatenation ATGACCCCTTGT _B	160	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	9	2211	17
						CTCGTTATGGCA _A_Concatenation GAGATTGTGTCC _B	161	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	9	2211	64
CTCGTTATGGCA _A_Concatenation ACTTGATGGTTT _B	162	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	9	2211	77
						CTCGTTATGGCA _A_Concatenation CCCTATGTTCTA _B	163	AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	9	2211	15
CCCGTAGGGGCT _A_Concatenation CTACGTGGCCCC _B	164	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	10	2211	86
						CCCGTAGGGGCT _A_Concatenation ATGACCCCTTGT _B	165	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	10	2211	17
CCCGTAGGGGCT _A_Concatenation ACTTGATGGTTT _B	166	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	10	2211	77
						CCCGTAGGGGCT _A_Concatenation AGAGTGCGCTCT _B	167	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	10	2211	14
CCCGTAGGGGCT _A_Concatenation GAGATTGTGTCC _B	168	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	10	2211	64
						CCCGTAGGGGCT _A_Concatenation ATAACTCCACGC _B	169	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	10	2211	44
CCCGTAGGGGCT _A_Concatenation CCCTATGTTCTA _B	170	APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	10	2211	15
						TCTTGGTTTTGA _A_Concatenation ATGACCCCTTGT _B	171	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	11	2211	17
TCTTGGTTTTGA _A_Concatenation GAGATTGTGTCC _B	172	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	11	2211	64
						TCTTGGTTTTGA _A_Concatenation ACTTGATGGTTT _B	173	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	11	2211	77
TCTTGGTTTTGA _A_Concatenation ATAACTCCACGC _B	174	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	11	2211	44
						TCTTGGTTTTGA _A_Concatenation CTACGTGGCCCC _B	175	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	11	2211	86
TCTTGGTTTTGA _A_Concatenation AGAGTGCGCTCT _B	176	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	11	2211	14
						TCTTGGTTTTGA _A_Concatenation CCCTATGTTCTA _B	177	ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	11	2211	15
CATCTCACCTAG _A_Concatenation ACTTGATGGTTT _B	178	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	12	2211	77
						CATCTCACCTAG _A_Concatenation GAGATTGTGTCC _B	179	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	12	2211	64
CATCTCACCTAG _A_Concatenation AGAGTGCGCTCT _B	180	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	12	2211	14
						CATCTCACCTAG _A_Concatenation CTACGTGGCCCC _B	181	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	12	2211	86
CATCTCACCTAG _A_Concatenation ATGACCCCTTGT _B	182	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	12	2211	17
						CATCTCACCTAG _A_Concatenation ATAACTCCACGC _B	183	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	12	2211	44
CATCTCACCTAG _A_Concatenation CCCTATGTTCTA _B	184	ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	12	2211	15
						TAAGATTCAACG _A_Concatenation ATGACCCCTTGT _B	185	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	13	2211	17
TAAGATTCAACG _A_Concatenation GAGATTGTGTCC _B	186	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	13	2211	64
						TAAGATTCAACG _A_Concatenation CTACGTGGCCCC _B	187	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	13	2211	86
TAAGATTCAACG _A_Concatenation ATAACTCCACGC _B	188	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	13	2211	44
						TAAGATTCAACG _A_Concatenation AGAGTGCGCTCT _B	189	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	13	2211	14
TAAGATTCAACG _A_Concatenation ACTTGATGGTTT _B	190	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	13	2211	77
						TAAGATTCAACG _A_Concatenation CCCTATGTTCTA _B	191	CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	13	2211	15
AGAGTGCGCTCT _A_Concatenation CCGCCCTTATGT _B	192	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	14	2211	98
						AGAGTGCGCTCT _A_Concatenation CTCCATTAATGA _B	193	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	14	2211	28
AGAGTGCGCTCT _A_Concatenation TGCCAGACGGTC _B	194	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	14	2211	75
						AGAGTGCGCTCT _A_Concatenation EPICXV.47_B	195	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	14	2211	34
AGAGTGCGCTCT _A_Concatenation AGCCAGGTCACC _B	196	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	14	2211	39
						AGAGTGCGCTCT _A_Concatenation GACTGTGGGCGG _B	197	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	14	2211	89
AGAGTGCGCTCT _A_Concatenation GAGTGACCTATT _B	198	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	14	2211	41
						AGAGTGCGCTCT _A_Concatenation CATTAGTCCCGC _B	199	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	14	2211	5
AGAGTGCGCTCT _A_Concatenation TCTTGGTTTTGA _B	200	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	14	2211	11
						AGAGTGCGCTCT _A_Concatenation ATGACAAAACGA _B	201	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	14	2211	40
AGAGTGCGCTCT _A_Concatenation TGATGAGCGCCC _B	202	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	14	2211	68
						AGAGTGCGCTCT _A_Concatenation ATTTGTAGACCG _B	203	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	14	2211	66
AGAGTGCGCTCT _A_Concatenation TAAGATTCAACG _B	204	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	14	2211	13
						AGAGTGCGCTCT _A_Concatenation CTCGCACCGAGG _B	205	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	14	2211	6
AGAGTGCGCTCT _A_Concatenation GCAACGAGGGTC _B	206	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	14	2211	74
						AGAGTGCGCTCT _A_Concatenation CATCTCACCTAG _B	207	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	14	2211	12
AGAGTGCGCTCT _A_Concatenation ACTCGTGTTGTC _B	208	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	14	2211	91
						AGAGTGCGCTCT _A_Concatenation AAGGGTAAATTG _B	209	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	14	2211	56
AGAGTGCGCTCT _A_Concatenation CTGCCGGTTGCG _B	210	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	14	2211	45
						AGAGTGCGCTCT _A_Concatenation TATTAAAAGTGC _B	211	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	14	2211	53
AGAGTGCGCTCT _A_Concatenation ACAACGTGCATA _B	212	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	14	2211	71
						AGAGTGCGCTCT _A_Concatenation CGATGGCGGAAT _B	213	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	14	2211	19
AGAGTGCGCTCT _A_Concatenation GTACATACCGAA _B	214	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	14	2211	55
						AGAGTGCGCTCT _A_Concatenation CCCTATGTTCTA _B	215	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	14	2211	15
AGAGTGCGCTCT _A_Concatenation CATTGTTTAAAT _B	216	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	14	2211	8
						AGAGTGCGCTCT _A_Concatenation TTAAATGAGGGC _B	217	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	14	2211	46
AGAGTGCGCTCT _A_Concatenation CACACCCGGCAG _B	218	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	14	2211	95
						AGAGTGCGCTCT _A_Concatenation CCAGACGGTCTG _B	219	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	14	2211	59
AGAGTGCGCTCT _A_Concatenation CCCCTTAGGAAT _B	220	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	14	2211	80
						AGAGTGCGCTCT _A_Concatenation CTCAGCGATATA _B	221	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	14	2211	27
AGAGTGCGCTCT _A_Concatenation AGCCGTGCTTGA _B	222	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	14	2211	32
						AGAGTGCGCTCT _A_Concatenation CAGTGACATAGT _B	223	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	14	2211	3
AGAGTGCGCTCT _A_Concatenation GCAGATTCGAAT _B	224	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	14	2211	43
						AGAGTGCGCTCT _A_Concatenation CATGCTAACACC _B	225	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	14	2211	88
AGAGTGCGCTCT _A_Concatenation AATCGAGACCAG _B	226	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	14	2211	24
						AGAGTGCGCTCT _A_Concatenation GTTCCACGCCTG _B	227	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	14	2211	97
AGAGTGCGCTCT _A_Concatenation ATTGTATCTAAC _B	228	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	14	2211	92
						AGAGTGCGCTCT _A_Concatenation GGCACAGCTCCA _B	229	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	14	2211	87
AGAGTGCGCTCT _A_Concatenation linker 2_B	230	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	14	2211	37
						AGAGTGCGCTCT _A_Concatenation CAACGCATGCCT _B	231	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	14	2211	100
AGAGTGCGCTCT _A_Concatenation GGAGGCACATCG _B	232	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	14	2211	76
						AGAGTGCGCTCT _A_Concatenation linker 3_B	233	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	14	2211	36
AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B	234	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	14	2211	14
						AGAGTGCGCTCT _A_Concatenation ACTTTAGTAACA _B	235	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	14	2211	57
AGAGTGCGCTCT _A_Concatenation ATGTGGCACGAC _B	236	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	14	2211	69
						AGAGTGCGCTCT _A_Concatenation CTCACGACAAGA _B	237	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	14	2211	4
AGAGTGCGCTCT _A_Concatenation ACCAGTATTTAA _B	238	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	14	2211	54
						AGAGTGCGCTCT _A_Concatenation TTTAACGGATTG _B	239	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	14	2211	81
AGAGTGCGCTCT _A_Concatenation linker 1_B	240	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	14	2211	35
						AGAGTGCGCTCT _A_Concatenation AAGACCGGTGCC _B	241	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	14	2211	73
AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B	242	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	14	2211	17
						AGAGTGCGCTCT _A_Concatenation GAGACAGCTCTC _B	243	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	14	2211	48
AGAGTGCGCTCT _A_Concatenation TATCGCAAGAAC _B	244	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	14	2211	63
						AGAGTGCGCTCT _A_Concatenation CGGCAATTGCTT _B	245	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	14	2211	82
AGAGTGCGCTCT _A_Concatenation ACGACTCACCGC _B	246	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	14	2211	60
						AGAGTGCGCTCT _A_Concatenation AGGCTTCCCGCT _B	247	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	14	2211	93
AGAGTGCGCTCT _A_Concatenation TAAAATTTATCA _B	248	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	14	2211	49
						AGAGTGCGCTCT _A_Concatenation TTCTAATTTCCT _B	249	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	14	2211	42
AGAGTGCGCTCT _A_Concatenation AAAACAAGCATT _B	250	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	14	2211	84
						AGAGTGCGCTCT _A_Concatenation CGCCGGCATACA _B	251	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	14	2211	16
AGAGTGCGCTCT _A_Concatenation TCTTAGAGGGTG _B	252	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	14	2211	29
						AGAGTGCGCTCT _A_Concatenation CTGGTAGTTGTT _B	253	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	14	2211	83
AGAGTGCGCTCT _A_Concatenation TACATGAGGCAC _B	254	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	14	2211	65
						AGAGTGCGCTCT _A_Concatenation GGCACTGTCGAG _B	255	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	14	2211	99
AGAGTGCGCTCT _A_Concatenation GCGAGGCAGACC _B	256	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	14	2211	70
						AGAGTGCGCTCT _A_Concatenation ATCTCTCAGTTC _B	257	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	14	2211	94
AGAGTGCGCTCT _A_Concatenation CTCGTTATGGCA _B	258	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	14	2211	9
						AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B	259	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	14	2211	77
AGAGTGCGCTCT _A_Concatenation AATCAACGAGCA _B	260	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	14	2211	79
						AGAGTGCGCTCT _A_Concatenation TATCTATCGTGT _B	261	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	14	2211	78
AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B	262	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	14	2211	64
						AGAGTGCGCTCT _A_Concatenation AGCCATAAACCT _B	263	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	14	2211	61
AGAGTGCGCTCT _A_Concatenation TGGCCCCCAGTT _B	264	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	14	2211	31
						AGAGTGCGCTCT _A_Concatenation TCTGTACCAACG _B	265	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	14	2211	25
AGAGTGCGCTCT _A_Concatenation CCCTGCCTCGGG _B	266	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	14	2211	26
						AGAGTGCGCTCT _A_Concatenation AATCGATCCTAC _B	267	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	14	2211	96
AGAGTGCGCTCT _A_Concatenation AGTTGCTTTGCT _B	268	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	14	2211	20
						AGAGTGCGCTCT _A_Concatenation AGTTAGGCTCTT _B	269	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	14	2211	21
AGAGTGCGCTCT _A_Concatenation GATCGCATGTTC _B	270	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	14	2211	58
						AGAGTGCGCTCT _A_Concatenation TCAGCCGTAGGC _B	271	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	14	2211	72
AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B	272	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	14	2211	44
						AGAGTGCGCTCT _A_Concatenation AAGCAACGATAT _B	273	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	14	2211	38
AGAGTGCGCTCT _A_Concatenation AAACTTTGAGCG _B	274	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	14	2211	7
						AGAGTGCGCTCT _A_Concatenation Stop_1_B	275	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	14	2211	1
AGAGTGCGCTCT _A_Concatenation GATGGAGCTACA _B	276	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	14	2211	23
						AGAGTGCGCTCT _A_Concatenation AATGGCACTAGC _B	277	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	14	2211	22
AGAGTGCGCTCT _A_Concatenation ACGGCGTAAGTA _B	278	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	14	2211	52
						AGAGTGCGCTCT _A_Concatenation ATCCAATCTGTG _B	279	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	14	2211	67
AGAGTGCGCTCT _A_Concatenation CATCTGAGTCGT _B	280	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	14	2211	33
						AGAGTGCGCTCT _A_Concatenation CCCGTAGGGGCT _B	281	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	14	2211	10
AGAGTGCGCTCT _A_Concatenation CCTAAATGCAAG _B	282	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	14	2211	85
						AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B	283	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	14	2211	86
AGAGTGCGCTCT _A_Concatenation GGCCTTTCGGGC _B	284	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	14	2211	30
						AGAGTGCGCTCT _A_Concatenation GGGAGTATGTCG _B	285	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	14	2211	47
AGAGTGCGCTCT _A_Concatenation GGTGTCTCGATT _B	286	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	14	2211	51
						AGAGTGCGCTCT _A_Concatenation GTCACCCTCCTT _B	287	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	14	2211	18
AGAGTGCGCTCT _A_Concatenation Stop_2_B	288	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	14	2211	2
						AGAGTGCGCTCT _A_Concatenation TACTTCTAGCGG _B	289	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	14	2211	90
AGAGTGCGCTCT _A_Concatenation TCTATCACAACT _B	290	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	14	2211	50
						AGAGTGCGCTCT _A_Concatenation TTAGTGCCATAC _B	291	CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKPGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	14	2211	62
CCCTATGTTCTA _A_Concatenation ATAACTCCACGC _B	292	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	15	2211	44
						CCCTATGTTCTA _A_Concatenation CTACGTGGCCCC _B	293	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	15	2211	86
CCCTATGTTCTA _A_Concatenation ACTTGATGGTTT _B	294	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	15	2211	77
						CCCTATGTTCTA _A_Concatenation ATGACCCCTTGT _B	295	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	15	2211	17
CCCTATGTTCTA _A_Concatenation GAGATTGTGTCC _B	296	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	15	2211	64
						CCCTATGTTCTA _A_Concatenation AGAGTGCGCTCT _B	297	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	15	2211	14
CCCTATGTTCTA _A_Concatenation AAAACAAGCATT _B	298	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	15	2211	84
						CCCTATGTTCTA _A_Concatenation AAACTTTGAGCG _B	299	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	15	2211	7
CCCTATGTTCTA _A_Concatenation AAGACCGGTGCC _B	300	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	15	2211	73
						CCCTATGTTCTA _A_Concatenation AAGCAACGATAT _B	301	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	15	2211	38
CCCTATGTTCTA _A_Concatenation AAGGGTAAATTG _B	302	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	15	2211	56
						CCCTATGTTCTA _A_Concatenation AATCAACGAGCA _B	303	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	15	2211	79
CCCTATGTTCTA _A_Concatenation AATCGAGACCAG _B	304	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	15	2211	24
						CCCTATGTTCTA _A_Concatenation AATCGATCCTAC _B	305	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	15	2211	96
CCCTATGTTCTA _A_Concatenation AATGGCACTAGC _B	306	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	15	2211	22
						CCCTATGTTCTA _A_Concatenation ACAACGTGCATA _B	307	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	15	2211	71
CCCTATGTTCTA _A_Concatenation ACCAGTATTTAA _B	308	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	15	2211	54
						CCCTATGTTCTA _A_Concatenation ACGACTCACCGC _B	309	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	15	2211	60
CCCTATGTTCTA _A_Concatenation ACGGCGTAAGTA _B	310	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	15	2211	52
						CCCTATGTTCTA _A_Concatenation ACTCGTGTTGTC _B	311	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	15	2211	91
CCCTATGTTCTA _A_Concatenation ACTTTAGTAACA _B	312	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	15	2211	57
						CCCTATGTTCTA _A_Concatenation AGCCAGGTCACC _B	313	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	15	2211	39
CCCTATGTTCTA _A_Concatenation AGCCATAAACCT _B	314	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	15	2211	61
						CCCTATGTTCTA _A_Concatenation AGCCGTGCTTGA _B	315	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	15	2211	32
CCCTATGTTCTA _A_Concatenation AGGCTTCCCGCT _B	316	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	15	2211	93
						CCCTATGTTCTA _A_Concatenation AGTTAGGCTCTT _B	317	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	15	2211	21
CCCTATGTTCTA _A_Concatenation AGTTGCTTTGCT _B	318	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	15	2211	20
						CCCTATGTTCTA _A_Concatenation ATCCAATCTGTG _B	319	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	15	2211	67
CCCTATGTTCTA _A_Concatenation ATCTCTCAGTTC _B	320	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	15	2211	94
						CCCTATGTTCTA _A_Concatenation ATGACAAAACGA _B	321	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	15	2211	40
CCCTATGTTCTA _A_Concatenation ATGTGGCACGAC _B	322	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	15	2211	69
						CCCTATGTTCTA _A_Concatenation ATTGTATCTAAC _B	323	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	15	2211	92
CCCTATGTTCTA _A_Concatenation ATTTGTAGACCG _B	324	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	15	2211	66
						CCCTATGTTCTA _A_Concatenation CAACGCATGCCT _B	325	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	15	2211	100
CCCTATGTTCTA _A_Concatenation CACACCCGGCAG _B	326	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	15	2211	95
						CCCTATGTTCTA _A_Concatenation CAGTGACATAGT _B	327	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	15	2211	3
CCCTATGTTCTA _A_Concatenation CATCTCACCTAG _B	328	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	15	2211	12
						CCCTATGTTCTA _A_Concatenation CATCTGAGTCGT _B	329	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	15	2211	33
CCCTATGTTCTA _A_Concatenation CATGCTAACACC _B	330	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	15	2211	88
						CCCTATGTTCTA _A_Concatenation CATTAGTCCCGC _B	331	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	15	2211	5
CCCTATGTTCTA _A_Concatenation CATTGTTTAAAT _B	332	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	15	2211	8
						CCCTATGTTCTA _A_Concatenation CCAGACGGTCTG _B	333	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	15	2211	59
CCCTATGTTCTA _A_Concatenation CCCCTTAGGAAT _B	334	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	15	2211	80
						CCCTATGTTCTA _A_Concatenation CCCGTAGGGGCT _B	335	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	15	2211	10
CCCTATGTTCTA _A_Concatenation CCCTATGTTCTA _B	336	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	15	2211	15
						CCCTATGTTCTA _A_Concatenation CCCTGCCTCGGG _B	337	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	15	2211	26
CCCTATGTTCTA _A_Concatenation CCGCCCTTATGT _B	338	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	15	2211	98
						CCCTATGTTCTA _A_Concatenation CCTAAATGCAAG _B	339	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	15	2211	85
CCCTATGTTCTA _A_Concatenation CGATGGCGGAAT _B	340	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	15	2211	19
						CCCTATGTTCTA _A_Concatenation CGCCGGCATACA _B	341	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	15	2211	16
CCCTATGTTCTA _A_Concatenation CGGCAATTGCTT _B	342	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	15	2211	82
						CCCTATGTTCTA _A_Concatenation CTCACGACAAGA _B	343	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	15	2211	4
CCCTATGTTCTA _A_Concatenation CTCAGCGATATA _B	344	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	15	2211	27
						CCCTATGTTCTA _A_Concatenation CTCCATTAATGA _B	345	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	15	2211	28
CCCTATGTTCTA _A_Concatenation CTCGCACCGAGG _B	346	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	15	2211	6
						CCCTATGTTCTA _A_Concatenation CTCGTTATGGCA _B	347	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	15	2211	9
CCCTATGTTCTA _A_Concatenation CTGCCGGTTGCG _B	348	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	15	2211	45
						CCCTATGTTCTA _A_Concatenation CTGGTAGTTGTT _B	349	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	15	2211	83
CCCTATGTTCTA _A_Concatenation EPICXV.47_B	350	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	15	2211	34
						CCCTATGTTCTA _A_Concatenation GACTGTGGGCGG _B	351	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	15	2211	89
CCCTATGTTCTA _A_Concatenation GAGACAGCTCTC _B	352	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	15	2211	48
						CCCTATGTTCTA _A_Concatenation GAGTGACCTATT _B	353	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	15	2211	41
CCCTATGTTCTA _A_Concatenation GATCGCATGTTC _B	354	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	15	2211	58
						CCCTATGTTCTA _A_Concatenation GATGGAGCTACA _B	355	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	15	2211	23
CCCTATGTTCTA _A_Concatenation GCAACGAGGGTC _B	356	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	15	2211	74
						CCCTATGTTCTA _A_Concatenation GCAGATTCGAAT _B	357	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	15	2211	43
CCCTATGTTCTA _A_Concatenation GCGAGGCAGACC _B	358	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	15	2211	70
						CCCTATGTTCTA _A_Concatenation GGAGGCACATCG _B	359	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	15	2211	76
CCCTATGTTCTA _A_Concatenation GGCACAGCTCCA _B	360	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	15	2211	87
						CCCTATGTTCTA _A_Concatenation GGCACTGTCGAG _B	361	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	15	2211	99
CCCTATGTTCTA _A_Concatenation GGCCTTTCGGGC _B	362	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	15	2211	30
						CCCTATGTTCTA _A_Concatenation GGGAGTATGTCG _B	363	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	15	2211	47
CCCTATGTTCTA _A_Concatenation GGTGTCTCGATT _B	364	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	15	2211	51
						CCCTATGTTCTA _A_Concatenation GTACATACCGAA _B	365	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	15	2211	55
CCCTATGTTCTA _A_Concatenation GTCACCCTCCTT _B	366	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	15	2211	18
						CCCTATGTTCTA _A_Concatenation GTTCCACGCCTG _B	367	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	15	2211	97
CCCTATGTTCTA _A_Concatenation Stop_1_B	368	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	15	2211	1
						CCCTATGTTCTA _A_Concatenation Stop_2_B	369	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	15	2211	2
CCCTATGTTCTA _A_Concatenation TAAAATTTATCA _B	370	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	15	2211	49
						CCCTATGTTCTA _A_Concatenation TAAGATTCAACG _B	371	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	15	2211	13
CCCTATGTTCTA _A_Concatenation TACATGAGGCAC _B	372	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	15	2211	65
						CCCTATGTTCTA _A_Concatenation TACTTCTAGCGG _B	373	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	15	2211	90
CCCTATGTTCTA _A_Concatenation TATCGCAAGAAC _B	374	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	15	2211	63
						CCCTATGTTCTA _A_Concatenation TATCTATCGTGT _B	375	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	15	2211	78
CCCTATGTTCTA _A_Concatenation TATTAAAAGTGC _B	376	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	15	2211	53
						CCCTATGTTCTA _A_Concatenation TCAGCCGTAGGC _B	377	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	15	2211	72
CCCTATGTTCTA _A_Concatenation TCTATCACAACT _B	378	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	15	2211	50
						CCCTATGTTCTA _A_Concatenation TCTGTACCAACG _B	379	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	15	2211	25
CCCTATGTTCTA _A_Concatenation TCTTAGAGGGTG _B	380	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	15	2211	29
						CCCTATGTTCTA _A_Concatenation TCTTGGTTTTGA _B	381	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	15	2211	11
CCCTATGTTCTA _A_Concatenation TGATGAGCGCCC _B	382	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	15	2211	68
						CCCTATGTTCTA _A_Concatenation TGCCAGACGGTC _B	383	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	15	2211	75
CCCTATGTTCTA _A_Concatenation TGGCCCCCAGTT _B	384	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	15	2211	31
						CCCTATGTTCTA _A_Concatenation TTAAATGAGGGC _B	385	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	15	2211	46
CCCTATGTTCTA _A_Concatenation TTAGTGCCATAC _B	386	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	15	2211	62
						CCCTATGTTCTA _A_Concatenation TTCTAATTTCCT _B	387	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	15	2211	42
CCCTATGTTCTA _A_Concatenation TTTAACGGATTG _B	388	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	15	2211	81
						CCCTATGTTCTA _A_Concatenation linker 1_B	389	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	15	2211	35
CCCTATGTTCTA _A_Concatenation linker 2_B	390	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	15	2211	37
						CCCTATGTTCTA _A_Concatenation linker 3_B	391	DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	15	2211	36
CGCCGGCATACA _A_Concatenation CTACGTGGCCCC _B	392	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	16	2211	86
						CGCCGGCATACA _A_Concatenation ACTTGATGGTTT _B	393	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	16	2211	77
CGCCGGCATACA _A_Concatenation GAGATTGTGTCC _B	394	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	16	2211	64
						CGCCGGCATACA _A_Concatenation AGAGTGCGCTCT _B	395	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	16	2211	14
CGCCGGCATACA _A_Concatenation ATGACCCCTTGT _B	396	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	16	2211	17
						CGCCGGCATACA _A_Concatenation ATAACTCCACGC _B	397	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	16	2211	44
CGCCGGCATACA _A_Concatenation CCCTATGTTCTA _B	398	DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPIGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	16	2211	15
						ATGACCCCTTGT _A_Concatenation AAGACCGGTGCC _B	399	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	17	2211	73
ATGACCCCTTGT _A_Concatenation ATGTGGCACGAC _B	400	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	17	2211	69
						ATGACCCCTTGT _A_Concatenation GATGGAGCTACA _B	401	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	17	2211	23
ATGACCCCTTGT _A_Concatenation GTTCCACGCCTG _B	402	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	17	2211	97
						ATGACCCCTTGT _A_Concatenation ACAACGTGCATA _B	403	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	17	2211	71
ATGACCCCTTGT _A_Concatenation CGGCAATTGCTT _B	404	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	17	2211	82
						ATGACCCCTTGT _A_Concatenation TGATGAGCGCCC _B	405	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	17	2211	68
ATGACCCCTTGT _A_Concatenation EPICXV.47_B	406	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	17	2211	34
						ATGACCCCTTGT _A_Concatenation CAGTGACATAGT _B	407	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	17	2211	3
ATGACCCCTTGT _A_Concatenation CTCACGACAAGA _B	408	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	17	2211	4
						ATGACCCCTTGT _A_Concatenation TAAAATTTATCA _B	409	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	17	2211	49
ATGACCCCTTGT _A_Concatenation GGCACAGCTCCA _B	410	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	17	2211	87
						ATGACCCCTTGT _A_Concatenation TCAGCCGTAGGC _B	411	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	17	2211	72
ATGACCCCTTGT _A_Concatenation CATTGTTTAAAT _B	412	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	17	2211	8
						ATGACCCCTTGT _A_Concatenation TGGCCCCCAGTT _B	413	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	17	2211	31
ATGACCCCTTGT _A_Concatenation ACTTTAGTAACA _B	414	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	17	2211	57
						ATGACCCCTTGT _A_Concatenation CATCTCACCTAG _B	415	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	17	2211	12
ATGACCCCTTGT _A_Concatenation TACATGAGGCAC _B	416	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	17	2211	65
						ATGACCCCTTGT _A_Concatenation GACTGTGGGCGG _B	417	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	17	2211	89
ATGACCCCTTGT _A_Concatenation TACTTCTAGCGG _B	418	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	17	2211	90
						ATGACCCCTTGT _A_Concatenation ATTGTATCTAAC _B	419	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	17	2211	92
ATGACCCCTTGT _A_Concatenation GGGAGTATGTCG _B	420	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	17	2211	47
						ATGACCCCTTGT _A_Concatenation TTCTAATTTCCT _B	421	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	17	2211	42
ATGACCCCTTGT _A_Concatenation CCAGACGGTCTG _B	422	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	17	2211	59
						ATGACCCCTTGT _A_Concatenation CTCGCACCGAGG _B	423	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	17	2211	6
ATGACCCCTTGT _A_Concatenation ACGGCGTAAGTA _B	424	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	17	2211	52
						ATGACCCCTTGT _A_Concatenation TCTTAGAGGGTG _B	425	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	17	2211	29
ATGACCCCTTGT _A_Concatenation CGATGGCGGAAT _B	426	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	17	2211	19
						ATGACCCCTTGT _A_Concatenation CTGCCGGTTGCG _B	427	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	17	2211	45
ATGACCCCTTGT _A_Concatenation GTACATACCGAA _B	428	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	17	2211	55
						ATGACCCCTTGT _A_Concatenation GCAACGAGGGTC _B	429	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	17	2211	74
ATGACCCCTTGT _A_Concatenation ATGACAAAACGA _B	430	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	17	2211	40
						ATGACCCCTTGT _A_Concatenation GATCGCATGTTC _B	431	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	17	2211	58
ATGACCCCTTGT _A_Concatenation GCGAGGCAGACC _B	432	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	17	2211	70
						ATGACCCCTTGT _A_Concatenation TTAAATGAGGGC _B	433	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	17	2211	46
ATGACCCCTTGT _A_Concatenation ACTCGTGTTGTC _B	434	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	17	2211	90
						ATGACCCCTTGT _A_Concatenation AAGGGTAAATTG _B	435	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	17	2211	56
ATGACCCCTTGT _A_Concatenation AATGGCACTAGC _B	436	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	17	2211	22
						ATGACCCCTTGT _A_Concatenation CATTAGTCCCGC _B	437	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	17	2211	5
ATGACCCCTTGT _A_Concatenation AATCAACGAGCA _B	438	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	17	2211	79
						ATGACCCCTTGT _A_Concatenation CGCCGGCATACA _B	439	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	17	2211	16
ATGACCCCTTGT _A_Concatenation TATTAAAAGTGC _B	440	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	17	2211	53
						ATGACCCCTTGT _A_Concatenation AATCGAGACCAG _B	441	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	17	2211	24
ATGACCCCTTGT _A_Concatenation CCCTGCCTCGGG _B	442	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	17	2211	26
						ATGACCCCTTGT _A_Concatenation CTCGTTATGGCA _B	443	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	17	2211	9
ATGACCCCTTGT _A_Concatenation TAAGATTCAACG _B	444	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	17	2211	13
						ATGACCCCTTGT _A_Concatenation ACGACTCACCGC _B	445	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	17	2211	60
ATGACCCCTTGT _A_Concatenation Stop_1_B	446	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	17	2211	1
						ATGACCCCTTGT _A_Concatenation Stop_2_B	447	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	17	2211	2
ATGACCCCTTGT _A_Concatenation AGCCGTGCTTGA _B	448	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	17	2211	32
						ATGACCCCTTGT _A_Concatenation GGAGGCACATCG _B	449	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	17	2211	76
ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B	450	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	17	2211	77
						ATGACCCCTTGT _A_Concatenation ACCAGTATTTAA _B	451	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	17	2211	54
ATGACCCCTTGT _A_Concatenation AGCCATAAACCT _B	452	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	17	2211	61
						ATGACCCCTTGT _A_Concatenation ATTTGTAGACCG _B	453	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	17	2211	66
ATGACCCCTTGT _A_Concatenation CATGCTAACACC _B	454	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	17	2211	88
						ATGACCCCTTGT _A_Concatenation TATCGCAAGAAC _B	455	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	17	2211	63
ATGACCCCTTGT _A_Concatenation AAGCAACGATAT _B	456	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	17	2211	38
						ATGACCCCTTGT _A_Concatenation linker 3_B	457	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	17	2211	36
ATGACCCCTTGT _A_Concatenation CTCCATTAATGA _B	458	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	17	2211	28
						ATGACCCCTTGT _A_Concatenation CTGGTAGTTGTT _B	459	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	17	2211	83
ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B	460	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	17	2211	14
						ATGACCCCTTGT _A_Concatenation AGTTGCTTTGCT _B	461	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	17	2211	20
ATGACCCCTTGT _A_Concatenation CTCAGCGATATA _B	462	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	17	2211	27
						ATGACCCCTTGT _A_Concatenation linker 2_B	463	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	17	2211	37
ATGACCCCTTGT _A_Concatenation linker 1_B	464	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	17	2211	35
						ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B	465	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	17	2211	64
ATGACCCCTTGT _A_Concatenation TGCCAGACGGTC _B	466	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	17	2211	75
						ATGACCCCTTGT _A_Concatenation GAGTGACCTATT _B	467	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	17	2211	41
ATGACCCCTTGT _A_Concatenation AATCGATCCTAC _B	468	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	17	2211	96
						ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B	469	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	17	2211	17
ATGACCCCTTGT _A_Concatenation TCTTGGTTTTGA _B	470	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	17	2211	11
						ATGACCCCTTGT _A_Concatenation TATCTATCGTGT _B	471	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	17	2211	78
ATGACCCCTTGT _A_Concatenation TTTAACGGATTG _B	472	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	17	2211	81
						ATGACCCCTTGT _A_Concatenation CACACCCGGCAG _B	473	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	17	2211	95
ATGACCCCTTGT _A_Concatenation TCTGTACCAACG _B	474	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	17	2211	25
						ATGACCCCTTGT _A_Concatenation GCAGATTCGAAT _B	475	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	17	2211	43
ATGACCCCTTGT _A_Concatenation CAACGCATGCCT _B	476	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	17	2211	100
						ATGACCCCTTGT _A_Concatenation AGTTAGGCTCTT _B	477	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	17	2211	21
ATGACCCCTTGT _A_Concatenation CCCTATGTTCTA _B	478	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	17	2211	15
						ATGACCCCTTGT _A_Concatenation CCCCTTAGGAAT _B	479	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	17	2211	80
ATGACCCCTTGT _A_Concatenation AAAACAAGCATT _B	480	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	17	2211	84
						ATGACCCCTTGT _A_Concatenation AAACTTTGAGCG _B	481	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	17	2211	7
ATGACCCCTTGT _A_Concatenation AGCCAGGTCACC _B	482	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	17	2211	39
						ATGACCCCTTGT _A_Concatenation AGGCTTCCCGCT _B	483	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	17	2211	93
ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B	484	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	17	2211	44
						ATGACCCCTTGT _A_Concatenation ATCCAATCTGTG _B	485	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	17	2211	67
ATGACCCCTTGT _A_Concatenation ATCTCTCAGTTC _B	486	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	17	2211	94
						ATGACCCCTTGT _A_Concatenation CATCTGAGTCGT _B	487	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	17	2211	33
ATGACCCCTTGT _A_Concatenation CCCGTAGGGGCT _B	488	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	17	2211	10
						ATGACCCCTTGT _A_Concatenation CCGCCCTTATGT _B	489	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	17	2211	98
ATGACCCCTTGT _A_Concatenation CCTAAATGCAAG _B	490	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	17	2211	85
						ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B	491	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	17	2211	86
ATGACCCCTTGT _A_Concatenation GAGACAGCTCTC _B	492	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	17	2211	48
						ATGACCCCTTGT _A_Concatenation GGCACTGTCGAG _B	493	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	17	2211	99
ATGACCCCTTGT _A_Concatenation GGCCTTTCGGGC _B	494	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	17	2211	30
						ATGACCCCTTGT _A_Concatenation GGTGTCTCGATT _B	495	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	17	2211	51
ATGACCCCTTGT _A_Concatenation GTCACCCTCCTT _B	496	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	17	2211	18
						ATGACCCCTTGT _A_Concatenation TCTATCACAACT _B	497	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	17	2211	50
ATGACCCCTTGT _A_Concatenation TTAGTGCCATAC _B	498	DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSVGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	17	2211	62
						GTCACCCTCCTT _A_Concatenation AGAGTGCGCTCT _B	499	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	18	2211	14
GTCACCCTCCTT _A_Concatenation ACTTGATGGTTT _B	500	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	18	2211	77
						GTCACCCTCCTT _A_Concatenation ATGACCCCTTGT _B	501	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	18	2211	17
GTCACCCTCCTT _A_Concatenation ATAACTCCACGC _B	502	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	18	2211	44
						GTCACCCTCCTT _A_Concatenation CTACGTGGCCCC _B	503	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	18	2211	86
GTCACCCTCCTT _A_Concatenation GAGATTGTGTCC _B	504	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	18	2211	64
						GTCACCCTCCTT _A_Concatenation CCCTATGTTCTA _B	505	DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	18	2211	15
CGATGGCGGAAT _A_Concatenation AGAGTGCGCTCT _B	506	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	19	2211	14
						CGATGGCGGAAT _A_Concatenation ACTTGATGGTTT _B	507	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	19	2211	77
CGATGGCGGAAT _A_Concatenation ATAACTCCACGC _B	508	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	19	2211	44
						CGATGGCGGAAT _A_Concatenation ATGACCCCTTGT _B	509	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	19	2211	17
CGATGGCGGAAT _A_Concatenation CTACGTGGCCCC _B	510	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	19	2211	86
						CGATGGCGGAAT _A_Concatenation GAGATTGTGTCC _B	511	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	19	2211	64
CGATGGCGGAAT _A_Concatenation CCCTATGTTCTA _B	512	DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	19	2211	15
						AGTTGCTTTGCT _A_Concatenation CTACGTGGCCCC _B	513	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	20	2211	86
AGTTGCTTTGCT _A_Concatenation ATAACTCCACGC _B	514	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	20	2211	44
						AGTTGCTTTGCT _A_Concatenation GAGATTGTGTCC _B	515	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	20	2211	64
AGTTGCTTTGCT _A_Concatenation AGAGTGCGCTCT _B	516	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	20	2211	14
						AGTTGCTTTGCT _A_Concatenation ACTTGATGGTTT _B	517	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	20	2211	77
AGTTGCTTTGCT _A_Concatenation ATGACCCCTTGT _B	518	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	20	2211	17
						AGTTGCTTTGCT _A_Concatenation CCCTATGTTCTA _B	519	DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLMGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	20	2211	15
AGTTAGGCTCTT _A_Concatenation ACTTGATGGTTT _B	520	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	21	2211	77
						AGTTAGGCTCTT _A_Concatenation AGAGTGCGCTCT _B	521	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	21	2211	14
AGTTAGGCTCTT _A_Concatenation GAGATTGTGTCC _B	522	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	21	2211	64
						AGTTAGGCTCTT _A_Concatenation ATAACTCCACGC _B	523	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	21	2211	44
AGTTAGGCTCTT _A_Concatenation CTACGTGGCCCC _B	524	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	21	2211	86
						AGTTAGGCTCTT _A_Concatenation ATGACCCCTTGT _B	525	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	21	2211	17
AGTTAGGCTCTT _A_Concatenation CCCTATGTTCTA _B	526	EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	21	2211	15
						AATGGCACTAGC _A_Concatenation GAGATTGTGTCC _B	527	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	22	2211	64
AATGGCACTAGC _A_Concatenation ATAACTCCACGC _B	528	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	22	2211	44
						AATGGCACTAGC _A_Concatenation ATGACCCCTTGT _B	529	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	22	2211	17
AATGGCACTAGC _A_Concatenation ACTTGATGGTTT _B	530	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	22	2211	77
						AATGGCACTAGC _A_Concatenation AGAGTGCGCTCT _B	531	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	22	2211	14
AATGGCACTAGC _A_Concatenation CTACGTGGCCCC _B	532	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	22	2211	86
						AATGGCACTAGC _A_Concatenation CCCTATGTTCTA _B	533	EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYARGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	22	2211	15
GATGGAGCTACA _A_Concatenation CTACGTGGCCCC _B	534	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	23	2211	86
						GATGGAGCTACA _A_Concatenation AGAGTGCGCTCT _B	535	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	23	2211	14
GATGGAGCTACA _A_Concatenation ACTTGATGGTTT _B	536	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	23	2211	77
						GATGGAGCTACA _A_Concatenation GAGATTGTGTCC _B	537	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	23	2211	64
GATGGAGCTACA _A_Concatenation ATGACCCCTTGT _B	538	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	23	2211	17
						GATGGAGCTACA _A_Concatenation ATAACTCCACGC _B	539	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	23	2211	44
GATGGAGCTACA _A_Concatenation CCCTATGTTCTA _B	540	EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLFGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	23	2211	15
						AATCGAGACCAG _A_Concatenation CTACGTGGCCCC _B	541	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	24	2211	86
AATCGAGACCAG _A_Concatenation AGAGTGCGCTCT _B	542	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	24	2211	14
						AATCGAGACCAG _A_Concatenation ATGACCCCTTGT _B	543	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	24	2211	17
AATCGAGACCAG _A_Concatenation GAGATTGTGTCC _B	544	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	24	2211	64
						AATCGAGACCAG _A_Concatenation ATAACTCCACGC _B	545	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	24	2211	44
AATCGAGACCAG _A_Concatenation ACTTGATGGTTT _B	546	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	24	2211	77
						AATCGAGACCAG _A_Concatenation CCCTATGTTCTA _B	547	EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEHGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	24	2211	15
TCTGTACCAACG _A_Concatenation AGAGTGCGCTCT _B	548	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	25	2211	14
						TCTGTACCAACG _A_Concatenation ACTTGATGGTTT _B	549	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	25	2211	77
TCTGTACCAACG _A_Concatenation GAGATTGTGTCC _B	550	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	25	2211	64
						TCTGTACCAACG _A_Concatenation ATGACCCCTTGT _B	551	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	25	2211	17
TCTGTACCAACG _A_Concatenation ATAACTCCACGC _B	552	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	25	2211	44
						TCTGTACCAACG _A_Concatenation CTACGTGGCCCC _B	553	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	25	2211	86
TCTGTACCAACG _A_Concatenation CCCTATGTTCTA _B	554	ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	25	2211	15
						CCCTGCCTCGGG _A_Concatenation AGAGTGCGCTCT _B	555	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	26	2211	14
CCCTGCCTCGGG _A_Concatenation CTACGTGGCCCC _B	556	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	26	2211	86
						CCCTGCCTCGGG _A_Concatenation GAGATTGTGTCC _B	557	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	26	2211	64
CCCTGCCTCGGG _A_Concatenation ATGACCCCTTGT _B	558	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	26	2211	17
						CCCTGCCTCGGG _A_Concatenation ACTTGATGGTTT _B	559	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	26	2211	77
CCCTGCCTCGGG _A_Concatenation ATAACTCCACGC _B	560	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	26	2211	44
						CCCTGCCTCGGG _A_Concatenation CCCTATGTTCTA _B	561	EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIYGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	26	2211	15
CTCAGCGATATA _A_Concatenation GAGATTGTGTCC _B	562	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	27	2211	64
						CTCAGCGATATA _A_Concatenation AGAGTGCGCTCT _B	563	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	27	2211	14
CTCAGCGATATA _A_Concatenation CTACGTGGCCCC _B	564	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	27	2211	86
						CTCAGCGATATA _A_Concatenation ACTTGATGGTTT _B	565	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	27	2211	77
CTCAGCGATATA _A_Concatenation ATAACTCCACGC _B	566	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	27	2211	44
						CTCAGCGATATA _A_Concatenation ATGACCCCTTGT _B	567	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	27	2211	17
CTCAGCGATATA _A_Concatenation CCCTATGTTCTA _B	568	FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGGGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	27	2211	15
						CTCCATTAATGA _A_Concatenation ATAACTCCACGC _B	569	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	28	2211	44
CTCCATTAATGA _A_Concatenation ACTTGATGGTTT _B	570	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	28	2211	77
						CTCCATTAATGA _A_Concatenation GAGATTGTGTCC _B	571	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	28	2211	64
CTCCATTAATGA _A_Concatenation AGAGTGCGCTCT _B	572	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	28	2211	14
						CTCCATTAATGA _A_Concatenation ATGACCCCTTGT _B	573	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	28	2211	17
CTCCATTAATGA _A_Concatenation CTACGTGGCCCC _B	574	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	28	2211	86
						CTCCATTAATGA _A_Concatenation CCCTATGTTCTA _B	575	FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	28	2211	15
TCTTAGAGGGTG _A_Concatenation ATGACCCCTTGT _B	576	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	29	2211	17
						TCTTAGAGGGTG _A_Concatenation AGAGTGCGCTCT _B	577	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	29	2211	14
TCTTAGAGGGTG _A_Concatenation CTACGTGGCCCC _B	578	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	29	2211	86
						TCTTAGAGGGTG _A_Concatenation GAGATTGTGTCC _B	579	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	29	2211	64
TCTTAGAGGGTG _A_Concatenation ATAACTCCACGC _B	580	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	29	2211	44
						TCTTAGAGGGTG _A_Concatenation ACTTGATGGTTT _B	581	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	29	2211	77
TCTTAGAGGGTG _A_Concatenation CCCTATGTTCTA _B	582	FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	29	2211	15
						GGCCTTTCGGGC _A_Concatenation GAGATTGTGTCC _B	583	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	30	2211	64
GGCCTTTCGGGC _A_Concatenation ACTTGATGGTTT _B	584	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	30	2211	77
						GGCCTTTCGGGC _A_Concatenation ATAACTCCACGC _B	585	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	30	2211	44
GGCCTTTCGGGC _A_Concatenation ATGACCCCTTGT _B	586	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	30	2211	17
						GGCCTTTCGGGC _A_Concatenation CTACGTGGCCCC _B	587	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	30	2211	86
GGCCTTTCGGGC _A_Concatenation AGAGTGCGCTCT _B	588	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	30	2211	14
						GGCCTTTCGGGC _A_Concatenation CCCTATGTTCTA _B	589	GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	30	2211	15
TGGCCCCCAGTT _A_Concatenation CTACGTGGCCCC _B	590	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	31	2211	86
						TGGCCCCCAGTT _A_Concatenation ATGACCCCTTGT _B	591	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	31	2211	17
TGGCCCCCAGTT _A_Concatenation GAGATTGTGTCC _B	592	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	31	2211	64
						TGGCCCCCAGTT _A_Concatenation ACTTGATGGTTT _B	593	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	31	2211	77
TGGCCCCCAGTT _A_Concatenation AGAGTGCGCTCT _B	594	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	31	2211	14
						TGGCCCCCAGTT _A_Concatenation ATAACTCCACGC _B	595	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	31	2211	44
TGGCCCCCAGTT _A_Concatenation CCCTATGTTCTA _B	596	GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQINGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	31	2211	15
						AGCCGTGCTTGA _A_Concatenation GAGATTGTGTCC _B	597	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	32	2211	64
AGCCGTGCTTGA _A_Concatenation ATGACCCCTTGT _B	598	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	32	2211	17
						AGCCGTGCTTGA _A_Concatenation AGAGTGCGCTCT _B	599	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	32	2211	14
AGCCGTGCTTGA _A_Concatenation CTACGTGGCCCC _B	600	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	32	2211	86
						AGCCGTGCTTGA _A_Concatenation ACTTGATGGTTT _B	601	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	32	2211	77
AGCCGTGCTTGA _A_Concatenation ATAACTCCACGC _B	602	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	32	2211	44
						AGCCGTGCTTGA _A_Concatenation CCCTATGTTCTA _B	603	GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIYGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	32	2211	15
CATCTGAGTCGT _A_Concatenation CTACGTGGCCCC _B	604	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	33	2211	86
						CATCTGAGTCGT _A_Concatenation GAGATTGTGTCC _B	605	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	33	2211	64
CATCTGAGTCGT _A_Concatenation ACTTGATGGTTT _B	606	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	33	2211	77
						CATCTGAGTCGT _A_Concatenation ATGACCCCTTGT _B	607	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	33	2211	17
CATCTGAGTCGT _A_Concatenation ATAACTCCACGC _B	608	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	33	2211	44
						CATCTGAGTCGT _A_Concatenation AGAGTGCGCTCT _B	609	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	33	2211	14
CATCTGAGTCGT _A_Concatenation CCCTATGTTCTA _B	610	GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	33	2211	15
						EPICXV.47-A\u splice_ CTACGTGGCCCC _b	611	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	34	2211	86
EPICXV.47-A\u splice_ ATAACTCCACGC _b	612	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	34	2211	44
						EPICXV.47-A\u splice_ AGAGTGCGCTCT _b	613	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	34	2211	14
EPICXV.47-A\u splice_ ATGACCCCTTGT _b	614	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	34	2211	17
						EPICXV.47-A\u splice_ GAGATTGTGTCC _b	615	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	34	2211	64
EPICXV.47-A\u splice_ ACTTGATGGTTT _b	616	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	34	2211	77
						EPICXV.47-A\u splice_ CCCTATGTTCTA _b	617	GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	34	2211	15
Linker_1_A/u splice_ CTACGTGGCCCC _b	618	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	35	2211	86
						Linker_1_A/u splice_ ATGACCCCTTGT _b	619	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	35	2211	17
Linker_1_A/u splice_ ACTTGATGGTTT _b	620	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	35	2211	77
						Linker_1_A/u splice_ AGAGTGCGCTCT _b	621	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	35	2211	14
Linker_1_A/u splice_ GAGATTGTGTCC _b	622	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	35	2211	64
						Linker_1_A/u splice_ ATAACTCCACGC _b	623	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	35	2211	44
Linker_1_A/u splice_ CCCTATGTTCTA _b	624	GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	35	2211	15
						Linker_ 3_A/u splice_ ATGACCCCTTGT _b	625	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	36	2211	17
Linker_ 3_A/u splice_ AGAGTGCGCTCT _b	626	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	36	2211	14
						Linker_ 3_A/u splice_ GAGATTGTGTCC _b	627	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	36	2211	64
Linker_ 3_A/u splice_ ATAACTCCACGC _b	628	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	36	2211	44
						Linker_ 3_A/u splice_ ACTTGATGGTTT _b	629	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	36	2211	77
Linker_ 3_A/u splice_ CTACGTGGCCCC _b	630	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	36	2211	86
						Linker_ 3_A/u splice_ CCCTATGTTCTA _b	631	GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	36	2211	15
Linker_ 2_A/u splice_ ATAACTCCACGC _b	632	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	37	2211	44
						Linker_ 2_A/u splice_ ATGACCCCTTGT _b	633	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	37	2211	17
Linker_ 2_A/u splice_ ACTTGATGGTTT _b	634	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	37	2211	77
						Linker_ 2_A/u splice_ AGAGTGCGCTCT _b	635	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	37	2211	14
Linker_ 2_A/u splice_ CTACGTGGCCCC _b	636	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	37	2211	86
						Linker_ 2_A/u splice_ GAGATTGTGTCC _b	637	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	37	2211	64
Linker_ 2_A/u splice_ CCCTATGTTCTA _b	638	GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPAGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	37	2211	15
						AAGCAACGATAT _A_Concatenation ACTTGATGGTTT _B	639	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	38	2211	77
AAGCAACGATAT _A_Concatenation CTACGTGGCCCC _B	640	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	38	2211	86
						AAGCAACGATAT _A_Concatenation AGAGTGCGCTCT _B	641	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	38	2211	14
AAGCAACGATAT _A_Concatenation ATAACTCCACGC _B	642	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	38	2211	44
						AAGCAACGATAT _A_Concatenation ATGACCCCTTGT _B	643	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	38	2211	17
AAGCAACGATAT _A_Concatenation GAGATTGTGTCC _B	644	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	38	2211	64
						AAGCAACGATAT _A_Concatenation CCCTATGTTCTA _B	645	GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	38	2211	15
AGCCAGGTCACC _A_Concatenation GAGATTGTGTCC _B	646	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	39	2211	64
						AGCCAGGTCACC _A_Concatenation ACTTGATGGTTT _B	647	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	39	2211	77
AGCCAGGTCACC _A_Concatenation CTACGTGGCCCC _B	648	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	39	2211	86
						AGCCAGGTCACC _A_Concatenation ATAACTCCACGC _B	649	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	39	2211	44
AGCCAGGTCACC _A_Concatenation AGAGTGCGCTCT _B	650	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	39	2211	14
						AGCCAGGTCACC _A_Concatenation ATGACCCCTTGT _B	651	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	39	2211	17
AGCCAGGTCACC _A_Concatenation CCCTATGTTCTA _B	652	GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	39	2211	15
						ATGACAAAACGA _A_Concatenation ATGACCCCTTGT _B	653	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	40	2211	17
ATGACAAAACGA _A_Concatenation ACTTGATGGTTT _B	654	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	40	2211	77
						ATGACAAAACGA _A_Concatenation GAGATTGTGTCC _B	655	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	40	2211	64
ATGACAAAACGA _A_Concatenation AGAGTGCGCTCT _B	656	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	40	2211	14
						ATGACAAAACGA _A_Concatenation ATAACTCCACGC _B	657	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	40	2211	44
ATGACAAAACGA _A_Concatenation CTACGTGGCCCC _B	658	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	40	2211	86
						ATGACAAAACGA _A_Concatenation CCCTATGTTCTA _B	659	HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	40	2211	15
GAGTGACCTATT _A_Concatenation ACTTGATGGTTT _B	660	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	41	2211	77
						GAGTGACCTATT _A_Concatenation CTACGTGGCCCC _B	661	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	41	2211	86
GAGTGACCTATT _A_Concatenation GAGATTGTGTCC _B	662	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	41	2211	64
						GAGTGACCTATT _A_Concatenation ATGACCCCTTGT _B	663	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	41	2211	17
GAGTGACCTATT _A_Concatenation AGAGTGCGCTCT _B	664	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	41	2211	14
						GAGTGACCTATT _A_Concatenation ATAACTCCACGC _B	665	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	41	2211	44
GAGTGACCTATT _A_Concatenation CCCTATGTTCTA _B	666	HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLIGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	41	2211	15
						TTCTAATTTCCT _A_Concatenation CTACGTGGCCCC _B	667	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	42	2211	86
TTCTAATTTCCT _A_Concatenation AGAGTGCGCTCT _B	668	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	42	2211	14
						TTCTAATTTCCT _A_Concatenation GAGATTGTGTCC _B	669	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	42	2211	64
TTCTAATTTCCT _A_Concatenation ATGACCCCTTGT _B	670	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	42	2211	17
						TTCTAATTTCCT _A_Concatenation ATAACTCCACGC _B	671	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	42	2211	44
TTCTAATTTCCT _A_Concatenation ACTTGATGGTTT _B	672	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	42	2211	77
						TTCTAATTTCCT _A_Concatenation CCCTATGTTCTA _B	673	IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	42	2211	15
GCAGATTCGAAT _A_Concatenation ATGACCCCTTGT _B	674	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	43	2211	17
						GCAGATTCGAAT _A_Concatenation AGAGTGCGCTCT _B	675	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	43	2211	14
GCAGATTCGAAT _A_Concatenation GAGATTGTGTCC _B	676	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	43	2211	64
						GCAGATTCGAAT _A_Concatenation ACTTGATGGTTT _B	677	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	43	2211	77
GCAGATTCGAAT _A_Concatenation ATAACTCCACGC _B	678	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	43	2211	44
						GCAGATTCGAAT _A_Concatenation CTACGTGGCCCC _B	679	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	43	2211	86
GCAGATTCGAAT _A_Concatenation CCCTATGTTCTA _B	680	KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	43	2211	15
						ATAACTCCACGC _A_Concatenation GGCACAGCTCCA _B	681	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	44	2211	87
ATAACTCCACGC _A_Concatenation CCGCCCTTATGT _B	682	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	44	2211	98
						ATAACTCCACGC _A_Concatenation CAACGCATGCCT _B	683	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	44	2211	100
ATAACTCCACGC _A_Concatenation TATTAAAAGTGC _B	684	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	44	2211	53
						ATAACTCCACGC _A_Concatenation ATGACAAAACGA _B	685	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	44	2211	40
ATAACTCCACGC _A_Concatenation ATCTCTCAGTTC _B	686	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	44	2211	94
						ATAACTCCACGC _A_Concatenation ACCAGTATTTAA _B	687	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	44	2211	54
ATAACTCCACGC _A_Concatenation ATCCAATCTGTG _B	688	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	44	2211	67
						ATAACTCCACGC _A_Concatenation ATGTGGCACGAC _B	689	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	44	2211	69
ATAACTCCACGC _A_Concatenation CATTAGTCCCGC _B	690	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	44	2211	5
						ATAACTCCACGC _A_Concatenation TCTGTACCAACG _B	691	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	44	2211	25
ATAACTCCACGC _A_Concatenation AAGCAACGATAT _B	692	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	44	2211	38
						ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B	693	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	44	2211	14
ATAACTCCACGC _A_Concatenation linker 3_B	694	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	44	2211	36
						ATAACTCCACGC _A_Concatenation CTCGTTATGGCA _B	695	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	44	2211	9
ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B	696	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	44	2211	44
						ATAACTCCACGC _A_Concatenation TAAAATTTATCA _B	697	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	44	2211	49
ATAACTCCACGC _A_Concatenation CGGCAATTGCTT _B	698	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	44	2211	82
						ATAACTCCACGC _A_Concatenation CTCGCACCGAGG _B	699	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	44	2211	6
ATAACTCCACGC _A_Concatenation CATCTCACCTAG _B	700	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	44	2211	12
						ATAACTCCACGC _A_Concatenation CGCCGGCATACA _B	701	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	44	2211	16
ATAACTCCACGC _A_Concatenation ATTTGTAGACCG _B	702	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	44	2211	66
						ATAACTCCACGC _A_Concatenation CATCTGAGTCGT _B	703	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	44	2211	33
ATAACTCCACGC _A_Concatenation CTCCATTAATGA _B	704	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	44	2211	28
						ATAACTCCACGC _A_Concatenation TCTTAGAGGGTG _B	705	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	44	2211	29
ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B	706	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	44	2211	77
						ATAACTCCACGC _A_Concatenation ATTGTATCTAAC _B	707	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	44	2211	92
ATAACTCCACGC _A_Concatenation CCAGACGGTCTG _B	708	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	44	2211	59
						ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B	709	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	44	2211	64
ATAACTCCACGC _A_Concatenation GCAACGAGGGTC _B	710	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	44	2211	74
						ATAACTCCACGC _A_Concatenation AAGACCGGTGCC _B	711	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	44	2211	73
ATAACTCCACGC _A_Concatenation GGCACTGTCGAG _B	712	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	44	2211	99
						ATAACTCCACGC _A_Concatenation AGCCGTGCTTGA _B	713	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	44	2211	32
ATAACTCCACGC _A_Concatenation AGCCATAAACCT _B	714	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	44	2211	61
						ATAACTCCACGC _A_Concatenation TACATGAGGCAC _B	715	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	44	2211	65
ATAACTCCACGC _A_Concatenation TGGCCCCCAGTT _B	716	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	44	2211	31
						ATAACTCCACGC _A_Concatenation CATGCTAACACC _B	717	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	44	2211	88
ATAACTCCACGC _A_Concatenation EPICXV.47_B	718	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	44	2211	34
						ATAACTCCACGC _A_Concatenation ACGACTCACCGC _B	719	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	44	2211	60
ATAACTCCACGC _A_Concatenation CGATGGCGGAAT _B	720	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	44	2211	19
						ATAACTCCACGC _A_Concatenation AAAACAAGCATT _B	721	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	44	2211	84
ATAACTCCACGC _A_Concatenation CCCCTTAGGAAT _B	722	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	44	2211	80
						ATAACTCCACGC _A_Concatenation TGCCAGACGGTC _B	723	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	44	2211	75
ATAACTCCACGC _A_Concatenation AATCAACGAGCA _B	724	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	44	2211	79
						ATAACTCCACGC _A_Concatenation AATGGCACTAGC _B	725	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	44	2211	22
ATAACTCCACGC _A_Concatenation GCAGATTCGAAT _B	726	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	44	2211	43
						ATAACTCCACGC _A_Concatenation AGTTAGGCTCTT _B	727	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	44	2211	21
ATAACTCCACGC _A_Concatenation TATCGCAAGAAC _B	728	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	44	2211	63
						ATAACTCCACGC _A_Concatenation ACAACGTGCATA _B	729	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	44	2211	71
ATAACTCCACGC _A_Concatenation GAGTGACCTATT _B	730	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	44	2211	41
						ATAACTCCACGC _A_Concatenation ACTTTAGTAACA _B	731	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	44	2211	57
ATAACTCCACGC _A_Concatenation CACACCCGGCAG _B	732	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	44	2211	95
						ATAACTCCACGC _A_Concatenation linker 1_B	733	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	44	2211	35
ATAACTCCACGC _A_Concatenation AAACTTTGAGCG _B	734	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	44	2211	7
						ATAACTCCACGC _A_Concatenation GCGAGGCAGACC _B	735	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	44	2211	70
ATAACTCCACGC _A_Concatenation TAAGATTCAACG _B	736	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	44	2211	13
						ATAACTCCACGC _A_Concatenation CCTAAATGCAAG _B	737	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	44	2211	85
ATAACTCCACGC _A_Concatenation CAGTGACATAGT _B	738	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	44	2211	3
						ATAACTCCACGC _A_Concatenation CCCTGCCTCGGG _B	739	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	44	2211	26
ATAACTCCACGC _A_Concatenation AGTTGCTTTGCT _B	740	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	44	2211	20
						ATAACTCCACGC _A_Concatenation TCAGCCGTAGGC _B	741	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	44	2211	72
ATAACTCCACGC _A_Concatenation GATGGAGCTACA _B	742	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	44	2211	23
						ATAACTCCACGC _A_Concatenation CCCTATGTTCTA _B	743	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	44	2211	15
ATAACTCCACGC _A_Concatenation ACGGCGTAAGTA _B	744	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	44	2211	52
						ATAACTCCACGC _A_Concatenation AATCGAGACCAG _B	745	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	44	2211	24
ATAACTCCACGC _A_Concatenation CTCAGCGATATA _B	746	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	44	2211	27
						ATAACTCCACGC _A_Concatenation Stop_1_B	747	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	44	2211	1
ATAACTCCACGC _A_Concatenation GGGAGTATGTCG _B	748	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	44	2211	47
						ATAACTCCACGC _A_Concatenation TCTTGGTTTTGA _B	749	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	44	2211	11
ATAACTCCACGC _A_Concatenation GTTCCACGCCTG _B	750	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	44	2211	97
						ATAACTCCACGC _A_Concatenation CTCACGACAAGA _B	751	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	44	2211	4
ATAACTCCACGC _A_Concatenation TTAAATGAGGGC _B	752	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	44	2211	46
						ATAACTCCACGC _A_Concatenation CTGGTAGTTGTT _B	753	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	44	2211	83
ATAACTCCACGC _A_Concatenation TATCTATCGTGT _B	754	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	44	2211	78
						ATAACTCCACGC _A_Concatenation GAGACAGCTCTC _B	755	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	44	2211	48
ATAACTCCACGC _A_Concatenation GGAGGCACATCG _B	756	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	44	2211	76
						ATAACTCCACGC _A_Concatenation TGATGAGCGCCC _B	757	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	44	2211	68
ATAACTCCACGC _A_Concatenation TTTAACGGATTG _B	758	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	44	2211	81
						ATAACTCCACGC _A_Concatenation TACTTCTAGCGG _B	759	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	44	2211	90
ATAACTCCACGC _A_Concatenation TCTATCACAACT _B	760	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	44	2211	50
						ATAACTCCACGC _A_Concatenation AGGCTTCCCGCT _B	761	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	44	2211	93
ATAACTCCACGC _A_Concatenation GATCGCATGTTC _B	762	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	44	2211	58
						ATAACTCCACGC _A_Concatenation CATTGTTTAAAT _B	763	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	44	2211	8
ATAACTCCACGC _A_Concatenation ACTCGTGTTGTC _B	764	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	44	2211	91
						ATAACTCCACGC _A_Concatenation CTGCCGGTTGCG _B	765	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	44	2211	45
ATAACTCCACGC _A_Concatenation linker 2_B	766	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	44	2211	37
						ATAACTCCACGC _A_Concatenation AATCGATCCTAC _B	767	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	44	2211	96
ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B	768	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	44	2211	17
						ATAACTCCACGC _A_Concatenation AAGGGTAAATTG _B	769	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	44	2211	56
ATAACTCCACGC _A_Concatenation GTACATACCGAA _B	770	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	44	2211	55
						ATAACTCCACGC _A_Concatenation AGCCAGGTCACC _B	771	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	44	2211	39
ATAACTCCACGC _A_Concatenation CCCGTAGGGGCT _B	772	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	44	2211	10
						ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B	773	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	44	2211	86
ATAACTCCACGC _A_Concatenation GACTGTGGGCGG _B	774	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	44	2211	89
						ATAACTCCACGC _A_Concatenation GGCCTTTCGGGC _B	775	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	44	2211	30
ATAACTCCACGC _A_Concatenation GGTGTCTCGATT _B	776	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	44	2211	51
						ATAACTCCACGC _A_Concatenation GTCACCCTCCTT _B	777	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	44	2211	18
ATAACTCCACGC _A_Concatenation Stop_2_B	778	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	44	2211	2
						ATAACTCCACGC _A_Concatenation TTAGTGCCATAC _B	779	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	44	2211	62
ATAACTCCACGC _A_Concatenation TTCTAATTTCCT _B	780	LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	44	2211	42
						CTGCCGGTTGCG _A_Concatenation GAGATTGTGTCC _B	781	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	45	2211	64
CTGCCGGTTGCG _A_Concatenation ATGACCCCTTGT _B	782	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	45	2211	17
						CTGCCGGTTGCG _A_Concatenation CTACGTGGCCCC _B	783	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	45	2211	86
CTGCCGGTTGCG _A_Concatenation AGAGTGCGCTCT _B	784	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	45	2211	14
						CTGCCGGTTGCG _A_Concatenation ATAACTCCACGC _B	785	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	45	2211	44
CTGCCGGTTGCG _A_Concatenation ACTTGATGGTTT _B	786	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	45	2211	77
						CTGCCGGTTGCG _A_Concatenation CCCTATGTTCTA _B	787	LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	45	2211	15
TTAAATGAGGGC _A_Concatenation ACTTGATGGTTT _B	788	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	46	2211	77
						TTAAATGAGGGC _A_Concatenation AGAGTGCGCTCT _B	789	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	46	2211	14
TTAAATGAGGGC _A_Concatenation ATAACTCCACGC _B	790	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	46	2211	44
						TTAAATGAGGGC _A_Concatenation ATGACCCCTTGT _B	791	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	46	2211	17
TTAAATGAGGGC _A_Concatenation CTACGTGGCCCC _B	792	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	46	2211	86
						TTAAATGAGGGC _A_Concatenation GAGATTGTGTCC _B	793	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	46	2211	64
TTAAATGAGGGC _A_Concatenation CCCTATGTTCTA _B	794	LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	46	2211	15
						GGGAGTATGTCG _A_Concatenation CTACGTGGCCCC _B	795	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	47	2211	86
GGGAGTATGTCG _A_Concatenation GAGATTGTGTCC _B	796	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	47	2211	64
						GGGAGTATGTCG _A_Concatenation ATGACCCCTTGT _B	797	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	47	2211	17
GGGAGTATGTCG _A_Concatenation ATAACTCCACGC _B	798	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	47	2211	44
						GGGAGTATGTCG _A_Concatenation ACTTGATGGTTT _B	799	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	47	2211	77
GGGAGTATGTCG _A_Concatenation AGAGTGCGCTCT _B	800	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	47	2211	14
						GGGAGTATGTCG _A_Concatenation CCCTATGTTCTA _B	801	LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	47	2211	15
GAGACAGCTCTC _A_Concatenation ATAACTCCACGC _B	802	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	48	2211	44
						GAGACAGCTCTC _A_Concatenation CTACGTGGCCCC _B	803	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	48	2211	86
GAGACAGCTCTC _A_Concatenation GAGATTGTGTCC _B	804	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	48	2211	64
						GAGACAGCTCTC _A_Concatenation ATGACCCCTTGT _B	805	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	48	2211	17
GAGACAGCTCTC _A_Concatenation ACTTGATGGTTT _B	806	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	48	2211	77
						GAGACAGCTCTC _A_Concatenation AGAGTGCGCTCT _B	807	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	48	2211	14
GAGACAGCTCTC _A_Concatenation CCCTATGTTCTA _B	808	LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMMGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	48	2211	15
						TAAAATTTATCA _A_Concatenation ACTTGATGGTTT _B	809	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	49	2211	77
TAAAATTTATCA _A_Concatenation AGAGTGCGCTCT _B	810	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	49	2211	14
						TAAAATTTATCA _A_Concatenation CTACGTGGCCCC _B	811	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	49	2211	86
TAAAATTTATCA _A_Concatenation ATAACTCCACGC _B	812	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	49	2211	44
						TAAAATTTATCA _A_Concatenation GAGATTGTGTCC _B	813	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	49	2211	64
TAAAATTTATCA _A_Concatenation ATGACCCCTTGT _B	814	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	49	2211	17
						TAAAATTTATCA _A_Concatenation CCCTATGTTCTA _B	815	LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	49	2211	15
TCTATCACAACT _A_Concatenation CTACGTGGCCCC _B	816	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	50	2211	86
						TCTATCACAACT _A_Concatenation ACTTGATGGTTT _B	817	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	50	2211	77
TCTATCACAACT _A_Concatenation AGAGTGCGCTCT _B	818	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	50	2211	14
						TCTATCACAACT _A_Concatenation GAGATTGTGTCC _B	819	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	50	2211	64
TCTATCACAACT _A_Concatenation ATGACCCCTTGT _B	820	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	50	2211	17
						TCTATCACAACT _A_Concatenation ATAACTCCACGC _B	821	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	50	2211	44
TCTATCACAACT _A_Concatenation CCCTATGTTCTA _B	822	LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	50	2211	15
						GGTGTCTCGATT _A_Concatenation AGAGTGCGCTCT _B	823	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	51	2211	14
GGTGTCTCGATT _A_Concatenation ACTTGATGGTTT _B	824	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	51	2211	77
						GGTGTCTCGATT _A_Concatenation CTACGTGGCCCC _B	825	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	51	2211	86
GGTGTCTCGATT _A_Concatenation ATGACCCCTTGT _B	826	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	51	2211	17
						GGTGTCTCGATT _A_Concatenation ATAACTCCACGC _B	827	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	51	2211	44
GGTGTCTCGATT _A_Concatenation GAGATTGTGTCC _B	828	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	51	2211	64
						GGTGTCTCGATT _A_Concatenation CCCTATGTTCTA _B	829	LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	51	2211	15
ACGGCGTAAGTA _A_Concatenation ATGACCCCTTGT _B	830	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	52	2211	17
						ACGGCGTAAGTA _A_Concatenation AGAGTGCGCTCT _B	831	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	52	2211	14
ACGGCGTAAGTA _A_Concatenation ACTTGATGGTTT _B	832	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	52	2211	77
						ACGGCGTAAGTA _A_Concatenation ATAACTCCACGC _B	833	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	52	2211	44
ACGGCGTAAGTA _A_Concatenation CTACGTGGCCCC _B	834	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	52	2211	86
						ACGGCGTAAGTA _A_Concatenation GAGATTGTGTCC _B	835	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	52	2211	64
ACGGCGTAAGTA _A_Concatenation CCCTATGTTCTA _B	836	LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	52	2211	15
						TATTAAAAGTGC _A_Concatenation GAGATTGTGTCC _B	837	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	53	2211	64
TATTAAAAGTGC _A_Concatenation ATGACCCCTTGT _B	838	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	53	2211	17
						TATTAAAAGTGC _A_Concatenation AGAGTGCGCTCT _B	839	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	53	2211	14
TATTAAAAGTGC _A_Concatenation ACTTGATGGTTT _B	840	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	53	2211	77
						TATTAAAAGTGC _A_Concatenation ATAACTCCACGC _B	841	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	53	2211	44
TATTAAAAGTGC _A_Concatenation CTACGTGGCCCC _B	842	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	53	2211	86
						TATTAAAAGTGC _A_Concatenation CCCTATGTTCTA _B	843	MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEIGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	53	2211	15
ACCAGTATTTAA _A_Concatenation ATGACCCCTTGT _B	844	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	54	2211	17
						ACCAGTATTTAA _A_Concatenation GAGATTGTGTCC _B	845	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	54	2211	64
ACCAGTATTTAA _A_Concatenation AGAGTGCGCTCT _B	846	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	54	2211	14
						ACCAGTATTTAA _A_Concatenation ACTTGATGGTTT _B	847	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	54	2211	77
ACCAGTATTTAA _A_Concatenation ATAACTCCACGC _B	848	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	54	2211	44
						ACCAGTATTTAA _A_Concatenation CTACGTGGCCCC _B	849	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	54	2211	86
ACCAGTATTTAA _A_Concatenation CCCTATGTTCTA _B	850	NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	54	2211	15
						GTACATACCGAA _A_Concatenation GAGATTGTGTCC _B	851	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	55	2211	64
GTACATACCGAA _A_Concatenation ACTTGATGGTTT _B	852	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	55	2211	77
						GTACATACCGAA _A_Concatenation CTACGTGGCCCC _B	853	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	55	2211	86
GTACATACCGAA _A_Concatenation AGAGTGCGCTCT _B	854	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	55	2211	14
						GTACATACCGAA _A_Concatenation ATGACCCCTTGT _B	855	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	55	2211	17
GTACATACCGAA _A_Concatenation ATAACTCCACGC _B	856	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	55	2211	44
						GTACATACCGAA _A_Concatenation CCCTATGTTCTA _B	857	NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIREGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	55	2211	15
AAGGGTAAATTG _A_Concatenation ACTTGATGGTTT _B	858	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	56	2211	77
						AAGGGTAAATTG _A_Concatenation CTACGTGGCCCC _B	859	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	56	2211	86
AAGGGTAAATTG _A_Concatenation ATGACCCCTTGT _B	860	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	56	2211	17
						AAGGGTAAATTG _A_Concatenation GAGATTGTGTCC _B	861	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	56	2211	64
AAGGGTAAATTG _A_Concatenation AGAGTGCGCTCT _B	862	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	56	2211	14
						AAGGGTAAATTG _A_Concatenation ATAACTCCACGC _B	863	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	56	2211	44
AAGGGTAAATTG _A_Concatenation CCCTATGTTCTA _B	864	NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	56	2211	15
						ACTTTAGTAACA _A_Concatenation ATGACCCCTTGT _B	865	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	57	2211	17
ACTTTAGTAACA _A_Concatenation ATAACTCCACGC _B	866	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	57	2211	44
						ACTTTAGTAACA _A_Concatenation ACTTGATGGTTT _B	867	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	57	2211	77
ACTTTAGTAACA _A_Concatenation AGAGTGCGCTCT _B	868	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	57	2211	14
						ACTTTAGTAACA _A_Concatenation GAGATTGTGTCC _B	869	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	57	2211	64
ACTTTAGTAACA _A_Concatenation CTACGTGGCCCC _B	870	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	57	2211	86
						ACTTTAGTAACA _A_Concatenation CCCTATGTTCTA _B	871	NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	57	2211	15
GATCGCATGTTC _A_Concatenation ATGACCCCTTGT _B	872	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	58	2211	17
						GATCGCATGTTC _A_Concatenation AGAGTGCGCTCT _B	873	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	58	2211	14
GATCGCATGTTC _A_Concatenation GAGATTGTGTCC _B	874	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	58	2211	64
						GATCGCATGTTC _A_Concatenation CTACGTGGCCCC _B	875	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	58	2211	86
GATCGCATGTTC _A_Concatenation ACTTGATGGTTT _B	876	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	58	2211	77
						GATCGCATGTTC _A_Concatenation ATAACTCCACGC _B	877	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	58	2211	44
GATCGCATGTTC _A_Concatenation CCCTATGTTCTA _B	878	NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	58	2211	15
						CCAGACGGTCTG _A_Concatenation ACTTGATGGTTT _B	879	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	59	2211	77
CCAGACGGTCTG _A_Concatenation CTACGTGGCCCC _B	880	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	59	2211	86
						CCAGACGGTCTG _A_Concatenation GAGATTGTGTCC _B	881	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	59	2211	64
CCAGACGGTCTG _A_Concatenation ATAACTCCACGC _B	882	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	59	2211	44
						CCAGACGGTCTG _A_Concatenation ATGACCCCTTGT _B	883	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	59	2211	17
CCAGACGGTCTG _A_Concatenation AGAGTGCGCTCT _B	884	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	59	2211	14
						CCAGACGGTCTG _A_Concatenation CCCTATGTTCTA _B	885	PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNNGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	59	2211	15
ACGACTCACCGC _A_Concatenation ATAACTCCACGC _B	886	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	60	2211	44
						ACGACTCACCGC _A_Concatenation GAGATTGTGTCC _B	887	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	60	2211	64
ACGACTCACCGC _A_Concatenation ATGACCCCTTGT _B	888	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	60	2211	17
						ACGACTCACCGC _A_Concatenation CTACGTGGCCCC _B	889	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	60	2211	86
ACGACTCACCGC _A_Concatenation ACTTGATGGTTT _B	890	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	60	2211	77
						ACGACTCACCGC _A_Concatenation AGAGTGCGCTCT _B	891	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	60	2211	14
ACGACTCACCGC _A_Concatenation CCCTATGTTCTA _B	892	PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	60	2211	15
						AGCCATAAACCT _A_Concatenation ATGACCCCTTGT _B	893	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	61	2211	17
AGCCATAAACCT _A_Concatenation AGAGTGCGCTCT _B	894	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	61	2211	14
						AGCCATAAACCT _A_Concatenation CTACGTGGCCCC _B	895	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	61	2211	86
AGCCATAAACCT _A_Concatenation GAGATTGTGTCC _B	896	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	61	2211	64
						AGCCATAAACCT _A_Concatenation ACTTGATGGTTT _B	897	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	61	2211	77
AGCCATAAACCT _A_Concatenation ATAACTCCACGC _B	898	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	61	2211	44
						AGCCATAAACCT _A_Concatenation CCCTATGTTCTA _B	899	PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	61	2211	15
TTAGTGCCATAC _A_Concatenation AGAGTGCGCTCT _B	900	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	62	2211	14
						TTAGTGCCATAC _A_Concatenation ATGACCCCTTGT _B	901	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	62	2211	17
TTAGTGCCATAC _A_Concatenation CTACGTGGCCCC _B	902	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	62	2211	86
						TTAGTGCCATAC _A_Concatenation ACTTGATGGTTT _B	903	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	62	2211	77
TTAGTGCCATAC _A_Concatenation ATAACTCCACGC _B	904	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	62	2211	44
						TTAGTGCCATAC _A_Concatenation GAGATTGTGTCC _B	905	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	62	2211	64
TTAGTGCCATAC _A_Concatenation CCCTATGTTCTA _B	906	PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	62	2211	15
						TATCGCAAGAAC _A_Concatenation ATGACCCCTTGT _B	907	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	63	2211	17
TATCGCAAGAAC _A_Concatenation ACTTGATGGTTT _B	908	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	63	2211	77
						TATCGCAAGAAC _A_Concatenation CTACGTGGCCCC _B	909	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	63	2211	86
TATCGCAAGAAC _A_Concatenation GAGATTGTGTCC _B	910	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	63	2211	64
						TATCGCAAGAAC _A_Concatenation AGAGTGCGCTCT _B	911	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	63	2211	14
TATCGCAAGAAC _A_Concatenation ATAACTCCACGC _B	912	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	63	2211	44
						TATCGCAAGAAC _A_Concatenation CCCTATGTTCTA _B	913	PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	63	2211	15
GAGATTGTGTCC _A_Concatenation CCAGACGGTCTG _B	914	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	64	2211	59
						GAGATTGTGTCC _A_Concatenation TAAGATTCAACG _B	915	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	64	2211	13
GAGATTGTGTCC _A_Concatenation TTAAATGAGGGC _B	916	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	64	2211	46
						GAGATTGTGTCC _A_Concatenation TCTGTACCAACG _B	917	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	64	2211	25
GAGATTGTGTCC _A_Concatenation CCCTGCCTCGGG _B	918	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	64	2211	26
						GAGATTGTGTCC _A_Concatenation CATGCTAACACC _B	919	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	64	2211	88
GAGATTGTGTCC _A_Concatenation GCAACGAGGGTC _B	920	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	64	2211	74
						GAGATTGTGTCC _A_Concatenation GACTGTGGGCGG _B	921	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	64	2211	89
GAGATTGTGTCC _A_Concatenation CCGCCCTTATGT _B	922	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	64	2211	98
						GAGATTGTGTCC _A_Concatenation EPICXV.47_B	923	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	64	2211	34
GAGATTGTGTCC _A_Concatenation CACACCCGGCAG _B	924	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	64	2211	95
						GAGATTGTGTCC _A_Concatenation CCCTATGTTCTA _B	925	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	64	2211	15
GAGATTGTGTCC _A_Concatenation GAGTGACCTATT _B	926	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	64	2211	41
						GAGATTGTGTCC _A_Concatenation CTCAGCGATATA _B	927	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	64	2211	27
GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B	928	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	64	2211	77
						GAGATTGTGTCC _A_Concatenation ATGACAAAACGA _B	929	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	64	2211	40
GAGATTGTGTCC _A_Concatenation Stop_1_B	930	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	64	2211	1
						GAGATTGTGTCC _A_Concatenation AAGGGTAAATTG _B	931	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	64	2211	56
GAGATTGTGTCC _A_Concatenation ATTTGTAGACCG _B	932	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	64	2211	66
						GAGATTGTGTCC _A_Concatenation AATCGAGACCAG _B	933	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	64	2211	24
GAGATTGTGTCC _A_Concatenation GATCGCATGTTC _B	934	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	64	2211	58
						GAGATTGTGTCC _A_Concatenation AATGGCACTAGC _B	935	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	64	2211	22
GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B	936	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	64	2211	64
						GAGATTGTGTCC _A_Concatenation GTTCCACGCCTG _B	937	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	64	2211	97
GAGATTGTGTCC _A_Concatenation ATCCAATCTGTG _B	938	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	64	2211	67
						GAGATTGTGTCC _A_Concatenation CGCCGGCATACA _B	939	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	64	2211	16
GAGATTGTGTCC _A_Concatenation linker 1_B	940	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	64	2211	35
						GAGATTGTGTCC _A_Concatenation GATGGAGCTACA _B	941	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	64	2211	23
GAGATTGTGTCC _A_Concatenation linker 3_B	942	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	64	2211	36
						GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B	943	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	64	2211	17
GAGATTGTGTCC _A_Concatenation ACGACTCACCGC _B	944	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	64	2211	60
						GAGATTGTGTCC _A_Concatenation TTTAACGGATTG _B	945	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	64	2211	81
GAGATTGTGTCC _A_Concatenation CTCACGACAAGA _B	946	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	64	2211	4
						GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B	947	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	64	2211	44
GAGATTGTGTCC _A_Concatenation ATGTGGCACGAC _B	948	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	64	2211	69
						GAGATTGTGTCC _A_Concatenation GGGAGTATGTCG _B	949	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	64	2211	47
GAGATTGTGTCC _A_Concatenation CGATGGCGGAAT _B	950	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	64	2211	19
						GAGATTGTGTCC _A_Concatenation TGCCAGACGGTC _B	951	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	64	2211	75
GAGATTGTGTCC _A_Concatenation TCAGCCGTAGGC _B	952	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	64	2211	72
						GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B	953	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	64	2211	14
GAGATTGTGTCC _A_Concatenation TGGCCCCCAGTT _B	954	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	64	2211	31
						GAGATTGTGTCC _A_Concatenation GGCACAGCTCCA _B	955	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	64	2211	87
GAGATTGTGTCC _A_Concatenation ACTTTAGTAACA _B	956	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	64	2211	57
						GAGATTGTGTCC _A_Concatenation ACTCGTGTTGTC _B	957	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	64	2211	91
GAGATTGTGTCC _A_Concatenation AAGACCGGTGCC _B	958	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	64	2211	73
						GAGATTGTGTCC _A_Concatenation TCTTAGAGGGTG _B	959	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	64	2211	29
GAGATTGTGTCC _A_Concatenation AGCCGTGCTTGA _B	960	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	64	2211	32
						GAGATTGTGTCC _A_Concatenation CTCGCACCGAGG _B	961	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	64	2211	6
GAGATTGTGTCC _A_Concatenation TACTTCTAGCGG _B	962	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	64	2211	90
						GAGATTGTGTCC _A_Concatenation AAAACAAGCATT _B	963	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	64	2211	84
GAGATTGTGTCC _A_Concatenation AGTTGCTTTGCT _B	964	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	64	2211	20
						GAGATTGTGTCC _A_Concatenation AATCAACGAGCA _B	965	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	64	2211	79
GAGATTGTGTCC _A_Concatenation AGCCATAAACCT _B	966	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	64	2211	61
						GAGATTGTGTCC _A_Concatenation GGAGGCACATCG _B	967	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	64	2211	76
GAGATTGTGTCC _A_Concatenation CTCGTTATGGCA _B	968	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	64	2211	9
						GAGATTGTGTCC _A_Concatenation TAAAATTTATCA _B	969	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	64	2211	49
GAGATTGTGTCC _A_Concatenation TCTTGGTTTTGA _B	970	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	64	2211	11
						GAGATTGTGTCC _A_Concatenation CATTAGTCCCGC _B	971	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	64	2211	5
GAGATTGTGTCC _A_Concatenation CAGTGACATAGT _B	972	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	64	2211	3
						GAGATTGTGTCC _A_Concatenation CATCTCACCTAG _B	973	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	64	2211	12
GAGATTGTGTCC _A_Concatenation ATCTCTCAGTTC _B	974	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	64	2211	94
						GAGATTGTGTCC _A_Concatenation CCTAAATGCAAG _B	975	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	64	2211	85
GAGATTGTGTCC _A_Concatenation GCGAGGCAGACC _B	976	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	64	2211	70
						GAGATTGTGTCC _A_Concatenation CGGCAATTGCTT _B	977	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	64	2211	82
GAGATTGTGTCC _A_Concatenation AAGCAACGATAT _B	978	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	64	2211	38
						GAGATTGTGTCC _A_Concatenation ACAACGTGCATA _B	979	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	64	2211	71
GAGATTGTGTCC _A_Concatenation CCCCTTAGGAAT _B	980	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	64	2211	80
						GAGATTGTGTCC _A_Concatenation GTACATACCGAA _B	981	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	64	2211	55
GAGATTGTGTCC _A_Concatenation TGATGAGCGCCC _B	982	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	64	2211	68
						GAGATTGTGTCC _A_Concatenation GCAGATTCGAAT _B	983	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	64	2211	43
GAGATTGTGTCC _A_Concatenation AGCCAGGTCACC _B	984	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	64	2211	39
						GAGATTGTGTCC _A_Concatenation TACATGAGGCAC _B	985	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	64	2211	65
GAGATTGTGTCC _A_Concatenation ATTGTATCTAAC _B	986	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	64	2211	92
						GAGATTGTGTCC _A_Concatenation CTGCCGGTTGCG _B	987	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	64	2211	45
GAGATTGTGTCC _A_Concatenation CTCCATTAATGA _B	988	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	64	2211	28
						GAGATTGTGTCC _A_Concatenation CTGGTAGTTGTT _B	989	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	64	2211	83
GAGATTGTGTCC _A_Concatenation linker 2_B	990	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	64	2211	37
						GAGATTGTGTCC _A_Concatenation AGTTAGGCTCTT _B	991	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	64	2211	21
GAGATTGTGTCC _A_Concatenation ACCAGTATTTAA _B	992	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	64	2211	54
						GAGATTGTGTCC _A_Concatenation TATTAAAAGTGC _B	993	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	64	2211	53
GAGATTGTGTCC _A_Concatenation CAACGCATGCCT _B	994	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	64	2211	100
						GAGATTGTGTCC _A_Concatenation GGCACTGTCGAG _B	995	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	64	2211	99
GAGATTGTGTCC _A_Concatenation CATTGTTTAAAT _B	996	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	64	2211	8
						GAGATTGTGTCC _A_Concatenation AAACTTTGAGCG _B	997	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	64	2211	7
GAGATTGTGTCC _A_Concatenation AATCGATCCTAC _B	998	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	64	2211	96
						GAGATTGTGTCC _A_Concatenation ACGGCGTAAGTA _B	999	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	64	2211	52
GAGATTGTGTCC _A_Concatenation AGGCTTCCCGCT _B	1000	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	64	2211	93
						GAGATTGTGTCC _A_Concatenation CATCTGAGTCGT _B	1001	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	64	2211	33
GAGATTGTGTCC _A_Concatenation CCCGTAGGGGCT _B	1002	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	64	2211	10
						GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B	1003	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	64	2211	86
GAGATTGTGTCC _A_Concatenation GAGACAGCTCTC _B	1004	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	64	2211	48
						GAGATTGTGTCC _A_Concatenation GGCCTTTCGGGC _B	1005	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	64	2211	30
GAGATTGTGTCC _A_Concatenation GGTGTCTCGATT _B	1006	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	64	2211	51
						GAGATTGTGTCC _A_Concatenation GTCACCCTCCTT _B	1007	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	64	2211	18
GAGATTGTGTCC _A_Concatenation Stop_2_B	1008	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	64	2211	2
						GAGATTGTGTCC _A_Concatenation TATCGCAAGAAC _B	1009	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	64	2211	63
GAGATTGTGTCC _A_Concatenation TATCTATCGTGT _B	1010	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	64	2211	78
						GAGATTGTGTCC _A_Concatenation TCTATCACAACT _B	1011	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	64	2211	50
GAGATTGTGTCC _A_Concatenation TTAGTGCCATAC _B	1012	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	64	2211	62
						GAGATTGTGTCC _A_Concatenation TTCTAATTTCCT _B	1013	PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	64	2211	42
TACATGAGGCAC _A_Concatenation ACTTGATGGTTT _B	1014	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	65	2211	77
						TACATGAGGCAC _A_Concatenation GAGATTGTGTCC _B	1015	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	65	2211	64
TACATGAGGCAC _A_Concatenation AGAGTGCGCTCT _B	1016	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	65	2211	14
						TACATGAGGCAC _A_Concatenation ATAACTCCACGC _B	1017	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	65	2211	44
TACATGAGGCAC _A_Concatenation ATGACCCCTTGT _B	1018	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	65	2211	17
						TACATGAGGCAC _A_Concatenation CTACGTGGCCCC _B	1019	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	65	2211	86
TACATGAGGCAC _A_Concatenation CCCTATGTTCTA _B	1020	PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	65	2211	15
						ATTTGTAGACCG _A_Concatenation AGAGTGCGCTCT _B	1021	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	66	2211	14
ATTTGTAGACCG _A_Concatenation ACTTGATGGTTT _B	1022	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	66	2211	77
						ATTTGTAGACCG _A_Concatenation CTACGTGGCCCC _B	1023	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	66	2211	86
ATTTGTAGACCG _A_Concatenation GAGATTGTGTCC _B	1024	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	66	2211	64
						ATTTGTAGACCG _A_Concatenation ATAACTCCACGC _B	1025	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	66	2211	44
ATTTGTAGACCG _A_Concatenation ATGACCCCTTGT _B	1026	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	66	2211	17
						ATTTGTAGACCG _A_Concatenation CCCTATGTTCTA _B	1027	PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENEGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	66	2211	15
ATCCAATCTGTG _A_Concatenation ATGACCCCTTGT _B	1028	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	67	2211	17
						ATCCAATCTGTG _A_Concatenation ATAACTCCACGC _B	1029	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	67	2211	44
ATCCAATCTGTG _A_Concatenation CTACGTGGCCCC _B	1030	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	67	2211	86
						ATCCAATCTGTG _A_Concatenation AGAGTGCGCTCT _B	1031	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	67	2211	14
ATCCAATCTGTG _A_Concatenation GAGATTGTGTCC _B	1032	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	67	2211	64
						ATCCAATCTGTG _A_Concatenation ACTTGATGGTTT _B	1033	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	67	2211	77
ATCCAATCTGTG _A_Concatenation CCCTATGTTCTA _B	1034	PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	67	2211	15
						TGATGAGCGCCC _A_Concatenation AGAGTGCGCTCT _B	1035	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	68	2211	14
TGATGAGCGCCC _A_Concatenation ATGACCCCTTGT _B	1036	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	68	2211	17
						TGATGAGCGCCC _A_Concatenation CTACGTGGCCCC _B	1037	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	68	2211	86
TGATGAGCGCCC _A_Concatenation GAGATTGTGTCC _B	1038	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	68	2211	64
						TGATGAGCGCCC _A_Concatenation ATAACTCCACGC _B	1039	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	68	2211	44
TGATGAGCGCCC _A_Concatenation ACTTGATGGTTT _B	1040	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	68	2211	77
						TGATGAGCGCCC _A_Concatenation CCCTATGTTCTA _B	1041	QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	68	2211	15
ATGTGGCACGAC _A_Concatenation ACTTGATGGTTT _B	1042	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	69	2211	77
						ATGTGGCACGAC _A_Concatenation ATGACCCCTTGT _B	1043	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	69	2211	17
ATGTGGCACGAC _A_Concatenation AGAGTGCGCTCT _B	1044	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	69	2211	14
						ATGTGGCACGAC _A_Concatenation ATAACTCCACGC _B	1045	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	69	2211	44
ATGTGGCACGAC _A_Concatenation CTACGTGGCCCC _B	1046	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	69	2211	86
						ATGTGGCACGAC _A_Concatenation GAGATTGTGTCC _B	1047	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	69	2211	64
ATGTGGCACGAC _A_Concatenation CCCTATGTTCTA _B	1048	QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	69	2211	15
						GCGAGGCAGACC _A_Concatenation GAGATTGTGTCC _B	1049	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	70	2211	64
GCGAGGCAGACC _A_Concatenation ATAACTCCACGC _B	1050	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	70	2211	44
						GCGAGGCAGACC _A_Concatenation AGAGTGCGCTCT _B	1051	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	70	2211	14
GCGAGGCAGACC _A_Concatenation ACTTGATGGTTT _B	1052	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	70	2211	77
						GCGAGGCAGACC _A_Concatenation CTACGTGGCCCC _B	1053	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	70	2211	86
GCGAGGCAGACC _A_Concatenation ATGACCCCTTGT _B	1054	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	70	2211	17
						GCGAGGCAGACC _A_Concatenation CCCTATGTTCTA _B	1055	QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRDGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	70	2211	15
ACAACGTGCATA _A_Concatenation GAGATTGTGTCC _B	1056	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	71	2211	64
						ACAACGTGCATA _A_Concatenation ATGACCCCTTGT _B	1057	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	71	2211	17
ACAACGTGCATA _A_Concatenation CTACGTGGCCCC _B	1058	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	71	2211	86
						ACAACGTGCATA _A_Concatenation AGAGTGCGCTCT _B	1059	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	71	2211	14
ACAACGTGCATA _A_Concatenation ACTTGATGGTTT _B	1060	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	71	2211	77
						ACAACGTGCATA _A_Concatenation ATAACTCCACGC _B	1061	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	71	2211	44
ACAACGTGCATA _A_Concatenation CCCTATGTTCTA _B	1062	RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDETGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	71	2211	15
						TCAGCCGTAGGC _A_Concatenation ATAACTCCACGC _B	1063	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	72	2211	44
TCAGCCGTAGGC _A_Concatenation CTACGTGGCCCC _B	1064	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	72	2211	86
						TCAGCCGTAGGC _A_Concatenation ATGACCCCTTGT _B	1065	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	72	2211	17
TCAGCCGTAGGC _A_Concatenation AGAGTGCGCTCT _B	1066	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	72	2211	14
						TCAGCCGTAGGC _A_Concatenation ACTTGATGGTTT _B	1067	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	72	2211	77
TCAGCCGTAGGC _A_Concatenation GAGATTGTGTCC _B	1068	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	72	2211	64
						TCAGCCGTAGGC _A_Concatenation CCCTATGTTCTA _B	1069	RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRRGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	72	2211	15
AAGACCGGTGCC _A_Concatenation ATAACTCCACGC _B	1070	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	73	2211	44
						AAGACCGGTGCC _A_Concatenation GAGATTGTGTCC _B	1071	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	73	2211	64
AAGACCGGTGCC _A_Concatenation ACTTGATGGTTT _B	1072	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	73	2211	77
						AAGACCGGTGCC _A_Concatenation ATGACCCCTTGT _B	1073	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	73	2211	17
AAGACCGGTGCC _A_Concatenation CTACGTGGCCCC _B	1074	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	73	2211	86
						AAGACCGGTGCC _A_Concatenation AGAGTGCGCTCT _B	1075	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	73	2211	14
AAGACCGGTGCC _A_Concatenation CCCTATGTTCTA _B	1076	RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	73	2211	15
						GCAACGAGGGTC _A_Concatenation CTACGTGGCCCC _B	1077	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	74	2211	86
GCAACGAGGGTC _A_Concatenation ATAACTCCACGC _B	1078	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	74	2211	44
						GCAACGAGGGTC _A_Concatenation GAGATTGTGTCC _B	1079	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	74	2211	64
GCAACGAGGGTC _A_Concatenation AGAGTGCGCTCT _B	1080	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	74	2211	14
						GCAACGAGGGTC _A_Concatenation ACTTGATGGTTT _B	1081	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	74	2211	77
GCAACGAGGGTC _A_Concatenation ATGACCCCTTGT _B	1082	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	74	2211	17
						GCAACGAGGGTC _A_Concatenation CCCTATGTTCTA _B	1083	RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	74	2211	15
TGCCAGACGGTC _A_Concatenation ACTTGATGGTTT _B	1084	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	75	2211	77
						TGCCAGACGGTC _A_Concatenation GAGATTGTGTCC _B	1085	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	75	2211	64
TGCCAGACGGTC _A_Concatenation ATGACCCCTTGT _B	1086	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	75	2211	17
						TGCCAGACGGTC _A_Concatenation CTACGTGGCCCC _B	1087	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	75	2211	86
TGCCAGACGGTC _A_Concatenation AGAGTGCGCTCT _B	1088	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	75	2211	14
						TGCCAGACGGTC _A_Concatenation ATAACTCCACGC _B	1089	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	75	2211	44
TGCCAGACGGTC _A_Concatenation CCCTATGTTCTA _B	1090	RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVGGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	75	2211	15
						GGAGGCACATCG _A_Concatenation ATAACTCCACGC _B	1091	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	76	2211	44
GGAGGCACATCG _A_Concatenation GAGATTGTGTCC _B	1092	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	76	2211	64
						GGAGGCACATCG _A_Concatenation ATGACCCCTTGT _B	1093	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	76	2211	17
GGAGGCACATCG _A_Concatenation ACTTGATGGTTT _B	1094	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	76	2211	77
						GGAGGCACATCG _A_Concatenation AGAGTGCGCTCT _B	1095	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	76	2211	14
GGAGGCACATCG _A_Concatenation CTACGTGGCCCC _B	1096	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	76	2211	86
						GGAGGCACATCG _A_Concatenation CCCTATGTTCTA _B	1097	RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	76	2211	15
ACTTGATGGTTT _A_Concatenation CATTGTTTAAAT _B	1098	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	77	2211	8
						ACTTGATGGTTT _A_Concatenation AATCGATCCTAC _B	1099	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	77	2211	96
ACTTGATGGTTT _A_Concatenation AATGGCACTAGC _B	1100	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	77	2211	22
						ACTTGATGGTTT _A_Concatenation AGTTGCTTTGCT _B	1101	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	77	2211	20
ACTTGATGGTTT _A_Concatenation TACTTCTAGCGG _B	1102	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	77	2211	90
						ACTTGATGGTTT _A_Concatenation CGGCAATTGCTT _B	1103	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	77	2211	82
ACTTGATGGTTT _A_Concatenation CACACCCGGCAG _B	1104	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	77	2211	95
						ACTTGATGGTTT _A_Concatenation TATCGCAAGAAC _B	1105	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	77	2211	63
ACTTGATGGTTT _A_Concatenation CCAGACGGTCTG _B	1106	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	77	2211	59
						ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	1107	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	77	2211	64
ACTTGATGGTTT _A_Concatenation CGCCGGCATACA _B	1108	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	77	2211	16
						ACTTGATGGTTT _A_Concatenation GGAGGCACATCG _B	1109	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	77	2211	76
ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B	1110	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	77	2211	86
						ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B	1111	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	77	2211	17
ACTTGATGGTTT _A_Concatenation CTCACGACAAGA _B	1112	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	77	2211	4
						ACTTGATGGTTT _A_Concatenation CAGTGACATAGT _B	1113	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	77	2211	3
ACTTGATGGTTT _A_Concatenation CCGCCCTTATGT _B	1114	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	77	2211	98
						ACTTGATGGTTT _A_Concatenation CATTAGTCCCGC _B	1115	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	77	2211	5
ACTTGATGGTTT _A_Concatenation GCAACGAGGGTC _B	1116	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	77	2211	74
						ACTTGATGGTTT _A_Concatenation CTCGCACCGAGG _B	1117	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	77	2211	6
ACTTGATGGTTT _A_Concatenation AAGGGTAAATTG _B	1118	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	77	2211	56
						ACTTGATGGTTT _A_Concatenation linker 1_B	1119	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	77	2211	35
ACTTGATGGTTT _A_Concatenation linker 3_B	1120	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	77	2211	36
						ACTTGATGGTTT _A_Concatenation TCTTAGAGGGTG _B	1121	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	77	2211	29
ACTTGATGGTTT _A_Concatenation TTCTAATTTCCT _B	1122	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	77	2211	42
						ACTTGATGGTTT _A_Concatenation TGCCAGACGGTC _B	1123	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	77	2211	75
ACTTGATGGTTT _A_Concatenation GATGGAGCTACA _B	1124	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	77	2211	23
						ACTTGATGGTTT _A_Concatenation AAGACCGGTGCC _B	1125	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	77	2211	73
ACTTGATGGTTT _A_Concatenation GCGAGGCAGACC _B	1126	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	77	2211	70
						ACTTGATGGTTT _A_Concatenation TCTTGGTTTTGA _B	1127	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	77	2211	11
ACTTGATGGTTT _A_Concatenation CAACGCATGCCT _B	1128	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	77	2211	100
						ACTTGATGGTTT _A_Concatenation GTTCCACGCCTG _B	1129	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	77	2211	97
ACTTGATGGTTT _A_Concatenation TATCTATCGTGT _B	1130	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	77	2211	78
						ACTTGATGGTTT _A_Concatenation CTCAGCGATATA _B	1131	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	77	2211	27
ACTTGATGGTTT _A_Concatenation CATCTGAGTCGT _B	1132	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	77	2211	33
						ACTTGATGGTTT _A_Concatenation TACATGAGGCAC _B	1133	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	77	2211	65
ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B	1134	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	77	2211	14
						ACTTGATGGTTT _A_Concatenation TAAGATTCAACG _B	1135	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	77	2211	13
ACTTGATGGTTT _A_Concatenation AGCCATAAACCT _B	1136	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	77	2211	61
						ACTTGATGGTTT _A_Concatenation CTCGTTATGGCA _B	1137	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	77	2211	9
ACTTGATGGTTT _A_Concatenation TTTAACGGATTG _B	1138	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	77	2211	81
						ACTTGATGGTTT _A_Concatenation CTGCCGGTTGCG _B	1139	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	77	2211	45
ACTTGATGGTTT _A_Concatenation ATGTGGCACGAC _B	1140	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	77	2211	69
						ACTTGATGGTTT _A_Concatenation TCAGCCGTAGGC _B	1141	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	77	2211	72
ACTTGATGGTTT _A_Concatenation TGGCCCCCAGTT _B	1142	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	77	2211	31
						ACTTGATGGTTT _A_Concatenation AGTTAGGCTCTT _B	1143	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	77	2211	21
ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B	1144	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	77	2211	77
						ACTTGATGGTTT _A_Concatenation linker 2_B	1145	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	77	2211	37
ACTTGATGGTTT _A_Concatenation EPICXV.47_B	1146	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	77	2211	34
						ACTTGATGGTTT _A_Concatenation TCTGTACCAACG _B	1147	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	77	2211	25
ACTTGATGGTTT _A_Concatenation GTACATACCGAA _B	1148	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	77	2211	55
						ACTTGATGGTTT _A_Concatenation TAAAATTTATCA _B	1149	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	77	2211	49
ACTTGATGGTTT _A_Concatenation CCCTATGTTCTA _B	1150	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	77	2211	15
						ACTTGATGGTTT _A_Concatenation ATGACAAAACGA _B	1151	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	77	2211	40
ACTTGATGGTTT _A_Concatenation CATGCTAACACC _B	1152	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	77	2211	88
						ACTTGATGGTTT _A_Concatenation GATCGCATGTTC _B	1153	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	77	2211	58
ACTTGATGGTTT _A_Concatenation AATCGAGACCAG _B	1154	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	77	2211	24
						ACTTGATGGTTT _A_Concatenation GGCACAGCTCCA _B	1155	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	77	2211	87
ACTTGATGGTTT _A_Concatenation ACCAGTATTTAA _B	1156	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	77	2211	54
						ACTTGATGGTTT _A_Concatenation Stop_1_B	1157	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	77	2211	1
ACTTGATGGTTT _A_Concatenation GACTGTGGGCGG _B	1158	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	77	2211	89
						ACTTGATGGTTT _A_Concatenation GGTGTCTCGATT _B	1159	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	77	2211	51
ACTTGATGGTTT _A_Concatenation ACTCGTGTTGTC _B	1160	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	77	2211	91
						ACTTGATGGTTT _A_Concatenation GAGTGACCTATT _B	1161	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	77	2211	41
ACTTGATGGTTT _A_Concatenation TGATGAGCGCCC _B	1162	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	77	2211	68
						ACTTGATGGTTT _A_Concatenation GGGAGTATGTCG _B	1163	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	77	2211	47
ACTTGATGGTTT _A_Concatenation TTAAATGAGGGC _B	1164	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	77	2211	46
						ACTTGATGGTTT _A_Concatenation CGATGGCGGAAT _B	1165	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	77	2211	19
ACTTGATGGTTT _A_Concatenation AGCCGTGCTTGA _B	1166	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	77	2211	32
						ACTTGATGGTTT _A_Concatenation CTCCATTAATGA _B	1167	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	77	2211	28
ACTTGATGGTTT _A_Concatenation CTGGTAGTTGTT _B	1168	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	77	2211	83
						ACTTGATGGTTT _A_Concatenation CATCTCACCTAG _B	1169	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	77	2211	12
ACTTGATGGTTT _A_Concatenation ATTTGTAGACCG _B	1170	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	77	2211	66
						ACTTGATGGTTT _A_Concatenation AATCAACGAGCA _B	1171	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	77	2211	79
ACTTGATGGTTT _A_Concatenation AAGCAACGATAT _B	1172	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	77	2211	38
						ACTTGATGGTTT _A_Concatenation ACTTTAGTAACA _B	1173	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	77	2211	57
ACTTGATGGTTT _A_Concatenation ACGACTCACCGC _B	1174	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	77	2211	60
						ACTTGATGGTTT _A_Concatenation GGCACTGTCGAG _B	1175	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	77	2211	99
ACTTGATGGTTT _A_Concatenation AGCCAGGTCACC _B	1176	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	77	2211	39
						ACTTGATGGTTT _A_Concatenation ACAACGTGCATA _B	1177	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	77	2211	71
ACTTGATGGTTT _A_Concatenation ATCTCTCAGTTC _B	1178	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	77	2211	94
						ACTTGATGGTTT _A_Concatenation GCAGATTCGAAT _B	1179	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	77	2211	43
ACTTGATGGTTT _A_Concatenation CCCTGCCTCGGG _B	1180	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	77	2211	26
						ACTTGATGGTTT _A_Concatenation TATTAAAAGTGC _B	1181	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	77	2211	53
ACTTGATGGTTT _A_Concatenation ATTGTATCTAAC _B	1182	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	77	2211	92
						ACTTGATGGTTT _A_Concatenation CCCCTTAGGAAT _B	1183	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	77	2211	80
ACTTGATGGTTT _A_Concatenation AAAACAAGCATT _B	1184	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	77	2211	84
						ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B	1185	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	77	2211	44
ACTTGATGGTTT _A_Concatenation GAGACAGCTCTC _B	1186	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	77	2211	48
						ACTTGATGGTTT _A_Concatenation AGGCTTCCCGCT _B	1187	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	77	2211	93
ACTTGATGGTTT _A_Concatenation AAACTTTGAGCG _B	1188	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	77	2211	7
						ACTTGATGGTTT _A_Concatenation ACGGCGTAAGTA _B	1189	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	77	2211	52
ACTTGATGGTTT _A_Concatenation ATCCAATCTGTG _B	1190	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	77	2211	67
						ACTTGATGGTTT _A_Concatenation CCCGTAGGGGCT _B	1191	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	77	2211	10
ACTTGATGGTTT _A_Concatenation CCTAAATGCAAG _B	1192	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	77	2211	85
						ACTTGATGGTTT _A_Concatenation GGCCTTTCGGGC _B	1193	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	77	2211	30
ACTTGATGGTTT _A_Concatenation GTCACCCTCCTT _B	1194	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	77	2211	18
						ACTTGATGGTTT _A_Concatenation Stop_2_B	1195	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	77	2211	2
ACTTGATGGTTT _A_Concatenation TCTATCACAACT _B	1196	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	77	2211	50
						ACTTGATGGTTT _A_Concatenation TTAGTGCCATAC _B	1197	RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRRGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	77	2211	62
TATCTATCGTGT _A_Concatenation GAGATTGTGTCC _B	1198	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	78	2211	64
						TATCTATCGTGT _A_Concatenation ATAACTCCACGC _B	1199	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	78	2211	44
TATCTATCGTGT _A_Concatenation ACTTGATGGTTT _B	1200	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	78	2211	77
						TATCTATCGTGT _A_Concatenation CTACGTGGCCCC _B	1201	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	78	2211	86
TATCTATCGTGT _A_Concatenation ATGACCCCTTGT _B	1202	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	78	2211	17
						TATCTATCGTGT _A_Concatenation AGAGTGCGCTCT _B	1203	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	78	2211	14
TATCTATCGTGT _A_Concatenation CCCTATGTTCTA _B	1204	RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	78	2211	15
						AATCAACGAGCA _A_Concatenation AGAGTGCGCTCT _B	1205	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	79	2211	14
AATCAACGAGCA _A_Concatenation CTACGTGGCCCC _B	1206	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	79	2211	86
						AATCAACGAGCA _A_Concatenation GAGATTGTGTCC _B	1207	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	79	2211	64
AATCAACGAGCA _A_Concatenation ATGACCCCTTGT _B	1208	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	79	2211	17
						AATCAACGAGCA _A_Concatenation ATAACTCCACGC _B	1209	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	79	2211	44
AATCAACGAGCA _A_Concatenation ACTTGATGGTTT _B	1210	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	79	2211	77
						AATCAACGAGCA _A_Concatenation CCCTATGTTCTA _B	1211	SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	79	2211	15
CCCCTTAGGAAT _A_Concatenation AGAGTGCGCTCT _B	1212	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	80	2211	14
						CCCCTTAGGAAT _A_Concatenation ACTTGATGGTTT _B	1213	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	80	2211	77
CCCCTTAGGAAT _A_Concatenation GAGATTGTGTCC _B	1214	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	80	2211	64
						CCCCTTAGGAAT _A_Concatenation ATAACTCCACGC _B	1215	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	80	2211	44
CCCCTTAGGAAT _A_Concatenation ATGACCCCTTGT _B	1216	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	80	2211	17
						CCCCTTAGGAAT _A_Concatenation CTACGTGGCCCC _B	1217	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	80	2211	86
CCCCTTAGGAAT _A_Concatenation CCCTATGTTCTA _B	1218	SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	80	2211	15
						TTTAACGGATTG _A_Concatenation GAGATTGTGTCC _B	1219	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	81	2211	64
TTTAACGGATTG _A_Concatenation AGAGTGCGCTCT _B	1220	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	81	2211	14
						TTTAACGGATTG _A_Concatenation ATAACTCCACGC _B	1221	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	81	2211	44
TTTAACGGATTG _A_Concatenation ACTTGATGGTTT _B	1222	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	81	2211	77
						TTTAACGGATTG _A_Concatenation ATGACCCCTTGT _B	1223	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	81	2211	17
TTTAACGGATTG _A_Concatenation CTACGTGGCCCC _B	1224	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	81	2211	86
						TTTAACGGATTG _A_Concatenation CCCTATGTTCTA _B	1225	SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	81	2211	15
CGGCAATTGCTT _A_Concatenation ACTTGATGGTTT _B	1226	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	82	2211	77
						CGGCAATTGCTT _A_Concatenation AGAGTGCGCTCT _B	1227	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	82	2211	14
CGGCAATTGCTT _A_Concatenation ATAACTCCACGC _B	1228	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	82	2211	44
						CGGCAATTGCTT _A_Concatenation ATGACCCCTTGT _B	1229	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	82	2211	17
CGGCAATTGCTT _A_Concatenation CTACGTGGCCCC _B	1230	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	82	2211	86
						CGGCAATTGCTT _A_Concatenation GAGATTGTGTCC _B	1231	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	82	2211	64
CGGCAATTGCTT _A_Concatenation CCCTATGTTCTA _B	1232	SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	82	2211	15
						CTGGTAGTTGTT _A_Concatenation GAGATTGTGTCC _B	1233	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	83	2211	64
CTGGTAGTTGTT _A_Concatenation ATGACCCCTTGT _B	1234	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	83	2211	17
						CTGGTAGTTGTT _A_Concatenation ACTTGATGGTTT _B	1235	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	83	2211	77
CTGGTAGTTGTT _A_Concatenation AGAGTGCGCTCT _B	1236	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	83	2211	14
						CTGGTAGTTGTT _A_Concatenation ATAACTCCACGC _B	1237	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	83	2211	44
CTGGTAGTTGTT _A_Concatenation CTACGTGGCCCC _B	1238	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	83	2211	86
						CTGGTAGTTGTT _A_Concatenation CCCTATGTTCTA _B	1239	SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKTGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	83	2211	15
AAAACAAGCATT _A_Concatenation CTACGTGGCCCC _B	1240	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	84	2211	86
						AAAACAAGCATT _A_Concatenation ATGACCCCTTGT _B	1241	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	84	2211	17
AAAACAAGCATT _A_Concatenation ATAACTCCACGC _B	1242	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	84	2211	44
						AAAACAAGCATT _A_Concatenation AGAGTGCGCTCT _B	1243	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	84	2211	14
AAAACAAGCATT _A_Concatenation ACTTGATGGTTT _B	1244	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	84	2211	77
						AAAACAAGCATT _A_Concatenation GAGATTGTGTCC _B	1245	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	84	2211	64
AAAACAAGCATT _A_Concatenation CCCTATGTTCTA _B	1246	STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	84	2211	15
						CCTAAATGCAAG _A_Concatenation ATAACTCCACGC _B	1247	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	85	2211	44
CCTAAATGCAAG _A_Concatenation ACTTGATGGTTT _B	1248	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	85	2211	77
						CCTAAATGCAAG _A_Concatenation AGAGTGCGCTCT _B	1249	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	85	2211	14
CCTAAATGCAAG _A_Concatenation ATGACCCCTTGT _B	1250	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	85	2211	17
						CCTAAATGCAAG _A_Concatenation CTACGTGGCCCC _B	1251	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	85	2211	86
CCTAAATGCAAG _A_Concatenation GAGATTGTGTCC _B	1252	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	85	2211	64
						CCTAAATGCAAG _A_Concatenation CCCTATGTTCTA _B	1253	SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFALGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	85	2211	15
CTACGTGGCCCC _A_Concatenation GGAGGCACATCG _B	1254	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL	86	2211	76
						CTACGTGGCCCC _A_Concatenation TATCTATCGTGT _B	1255	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS	86	2211	78
CTACGTGGCCCC _A_Concatenation CTCGTTATGGCA _B	1256	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF	86	2211	9
						CTACGTGGCCCC _A_Concatenation ATCTCTCAGTTC _B	1257	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK	86	2211	94
CTACGTGGCCCC _A_Concatenation AGTTAGGCTCTT _B	1258	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV	86	2211	21
						CTACGTGGCCCC _A_Concatenation TCTGTACCAACG _B	1259	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY	86	2211	25
CTACGTGGCCCC _A_Concatenation AGGCTTCCCGCT _B	1260	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV	86	2211	93
						CTACGTGGCCCC _A_Concatenation TCTTGGTTTTGA _B	1261	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL	86	2211	11
CTACGTGGCCCC _A_Concatenation TGATGAGCGCCC _B	1262	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL	86	2211	68
						CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B	1263	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	86	2211	64
CTACGTGGCCCC _A_Concatenation CATTGTTTAAAT _B	1264	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV	86	2211	8
						CTACGTGGCCCC _A_Concatenation ATGACAAAACGA _B	1265	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGHFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL	86	2211	40
CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B	1266	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	86	2211	14
						CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B	1267	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	86	2211	77
CTACGTGGCCCC _A_Concatenation TCTTAGAGGGTG _B	1268	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL	86	2211	29
						CTACGTGGCCCC _A_Concatenation AGCCATAAACCT _B	1269	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ	86	2211	61
CTACGTGGCCCC _A_Concatenation CCCCTTAGGAAT _B	1270	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD	86	2211	80
						CTACGTGGCCCC _A_Concatenation CTGGTAGTTGTT _B	1271	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT	86	2211	83
CTACGTGGCCCC _A_Concatenation AGTTGCTTTGCT _B	1272	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM	86	2211	20
						CTACGTGGCCCC _A_Concatenation GTTCCACGCCTG _B	1273	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS	86	2211	97
CTACGTGGCCCC _A_Concatenation GCGAGGCAGACC _B	1274	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGQWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD	86	2211	70
						CTACGTGGCCCC _A_Concatenation GAGTGACCTATT _B	1275	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGHKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI	86	2211	41
CTACGTGGCCCC _A_Concatenation TAAGATTCAACG _B	1276	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGCFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP	86	2211	13
						CTACGTGGCCCC _A_Concatenation AATCGATCCTAC _B	1277	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA	86	2211	96
CTACGTGGCCCC _A_Concatenation TCAGCCGTAGGC _B	1278	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR	86	2211	72
						CTACGTGGCCCC _A_Concatenation CATTAGTCCCGC _B	1279	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF	86	2211	5
CTACGTGGCCCC _A_Concatenation linker 3_B	1280	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD	86	2211	36
						CTACGTGGCCCC _A_Concatenation GAGACAGCTCTC _B	1281	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM	86	2211	48
CTACGTGGCCCC _A_Concatenation linker 2_B	1282	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA	86	2211	37
						CTACGTGGCCCC _A_Concatenation linker 1_B	1283	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK	86	2211	35
CTACGTGGCCCC _A_Concatenation CTGCCGGTTGCG _B	1284	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL	86	2211	45
						CTACGTGGCCCC _A_Concatenation AAGACCGGTGCC _B	1285	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF	86	2211	73
CTACGTGGCCCC _A_Concatenation CATCTGAGTCGT _B	1286	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS	86	2211	33
						CTACGTGGCCCC _A_Concatenation GTACATACCGAA _B	1287	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGNENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE	86	2211	55
CTACGTGGCCCC _A_Concatenation ATTTGTAGACCG _B	1288	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE	86	2211	66
						CTACGTGGCCCC _A_Concatenation Stop_1_B	1289	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSG***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK	86	2211	1
CTACGTGGCCCC _A_Concatenation CAGTGACATAGT _B	1290	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT	86	2211	3
						CTACGTGGCCCC _A_Concatenation ATGTGGCACGAC _B	1291	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC	86	2211	69
CTACGTGGCCCC _A_Concatenation TGCCAGACGGTC _B	1292	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG	86	2211	75
						CTACGTGGCCCC _A_Concatenation CGATGGCGGAAT _B	1293	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG	86	2211	19
CTACGTGGCCCC _A_Concatenation ACAACGTGCATA _B	1294	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET	86	2211	71
						CTACGTGGCCCC _A_Concatenation GCAACGAGGGTC _B	1295	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ	86	2211	74
CTACGTGGCCCC _A_Concatenation AATGGCACTAGC _B	1296	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGEGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR	86	2211	22
						CTACGTGGCCCC _A_Concatenation TTCTAATTTCCT _B	1297	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS	86	2211	42
CTACGTGGCCCC _A_Concatenation CTCGCACCGAGG _B	1298	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN	86	2211	6
						CTACGTGGCCCC _A_Concatenation GCAGATTCGAAT _B	1299	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP	86	2211	43
CTACGTGGCCCC _A_Concatenation TGGCCCCCAGTT _B	1300	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN	86	2211	31
						CTACGTGGCCCC _A_Concatenation ATTGTATCTAAC _B	1301	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD	86	2211	92
CTACGTGGCCCC _A_Concatenation TACATGAGGCAC _B	1302	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL	86	2211	65
						CTACGTGGCCCC _A_Concatenation CGGCAATTGCTT _B	1303	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK	86	2211	82
CTACGTGGCCCC _A_Concatenation ACTCGTGTTGTC _B	1304	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT	86	2211	91
						CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B	1305	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	86	2211	17
CTACGTGGCCCC _A_Concatenation AAACTTTGAGCG _B	1306	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ	86	2211	7
						CTACGTGGCCCC _A_Concatenation ACTTTAGTAACA _B	1307	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES	86	2211	57
CTACGTGGCCCC _A_Concatenation CCAGACGGTCTG _B	1308	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN	86	2211	59
						CTACGTGGCCCC _A_Concatenation AGCCGTGCTTGA _B	1309	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY	86	2211	32
CTACGTGGCCCC _A_Concatenation TTTAACGGATTG _B	1310	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN	86	2211	81
						CTACGTGGCCCC _A_Concatenation AATCGAGACCAG _B	1311	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGEPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH	86	2211	24
CTACGTGGCCCC _A_Concatenation CCGCCCTTATGT _B	1312	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH	86	2211	98
						CTACGTGGCCCC _A_Concatenation GGCACAGCTCCA _B	1313	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG	86	2211	87
CTACGTGGCCCC _A_Concatenation AGCCAGGTCACC _B	1314	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK	86	2211	39
						CTACGTGGCCCC _A_Concatenation GATCGCATGTTC _B	1315	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGNSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER	86	2211	58
CTACGTGGCCCC _A_Concatenation GATGGAGCTACA _B	1316	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGEMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF	86	2211	23
						CTACGTGGCCCC _A_Concatenation AATCAACGAGCA _B	1317	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE	86	2211	79
CTACGTGGCCCC _A_Concatenation TTAAATGAGGGC _B	1318	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ	86	2211	46
						CTACGTGGCCCC _A_Concatenation AAGCAACGATAT _B	1319	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL	86	2211	38
CTACGTGGCCCC _A_Concatenation GGTGTCTCGATT _B	1320	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV	86	2211	51
						CTACGTGGCCCC _A_Concatenation TAAAATTTATCA _B	1321	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY	86	2211	49
CTACGTGGCCCC _A_Concatenation CTCAGCGATATA _B	1322	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGFATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG	86	2211	27
						CTACGTGGCCCC _A_Concatenation EPICXV.47_B	1323	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	86	2211	34
CTACGTGGCCCC _A_Concatenation CACACCCGGCAG _B	1324	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS	86	2211	95
						CTACGTGGCCCC _A_Concatenation CATGCTAACACC _B	1325	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL	86	2211	88
CTACGTGGCCCC _A_Concatenation ACCAGTATTTAA _B	1326	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL	86	2211	54
						CTACGTGGCCCC _A_Concatenation CAACGCATGCCT _B	1327	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGYPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS	86	2211	100
CTACGTGGCCCC _A_Concatenation CATCTCACCTAG _B	1328	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA	86	2211	12
						CTACGTGGCCCC _A_Concatenation AAGGGTAAATTG _B	1329	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGNKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS	86	2211	56
CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B	1330	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	86	2211	44
						CTACGTGGCCCC _A_Concatenation GGGAGTATGTCG _B	1331	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS	86	2211	47
CTACGTGGCCCC _A_Concatenation CTCACGACAAGA _B	1332	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP	86	2211	4
						CTACGTGGCCCC _A_Concatenation TATCGCAAGAAC _B	1333	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV	86	2211	63
CTACGTGGCCCC _A_Concatenation CCCGTAGGGGCT _B	1334	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS	86	2211	10
						CTACGTGGCCCC _A_Concatenation CCCTATGTTCTA _B	1335	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	86	2211	15
CTACGTGGCCCC _A_Concatenation CCCTGCCTCGGG _B	1336	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGEVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY	86	2211	26
						CTACGTGGCCCC _A_Concatenation TACTTCTAGCGG _B	1337	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGTWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ	86	2211	90
CTACGTGGCCCC _A_Concatenation GGCACTGTCGAG _B	1338	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGYALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA	86	2211	99
						CTACGTGGCCCC _A_Concatenation CTCCATTAATGA _B	1339	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV	86	2211	28
CTACGTGGCCCC _A_Concatenation AAAACAAGCATT _B	1340	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSTFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS	86	2211	84
						CTACGTGGCCCC _A_Concatenation TATTAAAAGTGC _B	1341	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGMHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI	86	2211	53
CTACGTGGCCCC _A_Concatenation CGCCGGCATACA _B	1342	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI	86	2211	16
						CTACGTGGCCCC _A_Concatenation ACGACTCACCGC _B	1343	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK	86	2211	60
CTACGTGGCCCC _A_Concatenation ACGGCGTAAGTA _B	1344	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL	86	2211	52
						CTACGTGGCCCC _A_Concatenation ATCCAATCTGTG _B	1345	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT	86	2211	67
CTACGTGGCCCC _A_Concatenation CCTAAATGCAAG _B	1346	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGSVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL	86	2211	85
						CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B	1347	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	86	2211	86
CTACGTGGCCCC _A_Concatenation GACTGTGGGCGG _B	1348	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL	86	2211	89
						CTACGTGGCCCC _A_Concatenation GGCCTTTCGGGC _B	1349	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGGAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ	86	2211	30
CTACGTGGCCCC _A_Concatenation GTCACCCTCCTT _B	1350	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN	86	2211	18
						CTACGTGGCCCC _A_Concatenation Stop_2_B	1351	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSG***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE	86	2211	2
CTACGTGGCCCC _A_Concatenation TCTATCACAACT _B	1352	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH	86	2211	50
						CTACGTGGCCCC _A_Concatenation TTAGTGCCATAC _B	1353	TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLGSGGSGGSGGSGPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP	86	2211	62
GGCACAGCTCCA _A_Concatenation ATGACCCCTTGT _B	1354	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	87	2211	17
						GGCACAGCTCCA _A_Concatenation ACTTGATGGTTT _B	1355	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	87	2211	77
GGCACAGCTCCA _A_Concatenation ATAACTCCACGC _B	1356	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	87	2211	44
						GGCACAGCTCCA _A_Concatenation GAGATTGTGTCC _B	1357	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	87	2211	64
GGCACAGCTCCA _A_Concatenation CTACGTGGCCCC _B	1358	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	87	2211	86
						GGCACAGCTCCA _A_Concatenation AGAGTGCGCTCT _B	1359	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	87	2211	14
GGCACAGCTCCA _A_Concatenation CCCTATGTTCTA _B	1360	TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	87	2211	15
						CATGCTAACACC _A_Concatenation ATAACTCCACGC _B	1361	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	88	2211	44
CATGCTAACACC _A_Concatenation GAGATTGTGTCC _B	1362	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	88	2211	64
						CATGCTAACACC _A_Concatenation ATGACCCCTTGT _B	1363	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	88	2211	17
CATGCTAACACC _A_Concatenation ACTTGATGGTTT _B	1364	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	88	2211	77
						CATGCTAACACC _A_Concatenation CTACGTGGCCCC _B	1365	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	88	2211	86
CATGCTAACACC _A_Concatenation AGAGTGCGCTCT _B	1366	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	88	2211	14
						CATGCTAACACC _A_Concatenation CCCTATGTTCTA _B	1367	TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	88	2211	15
GACTGTGGGCGG _A_Concatenation GAGATTGTGTCC _B	1368	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	89	2211	64
						GACTGTGGGCGG _A_Concatenation ACTTGATGGTTT _B	1369	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	89	2211	77
GACTGTGGGCGG _A_Concatenation AGAGTGCGCTCT _B	1370	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	89	2211	14
						GACTGTGGGCGG _A_Concatenation ATAACTCCACGC _B	1371	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	89	2211	44
GACTGTGGGCGG _A_Concatenation ATGACCCCTTGT _B	1372	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	89	2211	17
						GACTGTGGGCGG _A_Concatenation CTACGTGGCCCC _B	1373	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	89	2211	86
GACTGTGGGCGG _A_Concatenation CCCTATGTTCTA _B	1374	TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	89	2211	15
						TACTTCTAGCGG _A_Concatenation ATGACCCCTTGT _B	1375	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	90	2211	17
TACTTCTAGCGG _A_Concatenation GAGATTGTGTCC _B	1376	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	90	2211	64
						TACTTCTAGCGG _A_Concatenation ATAACTCCACGC _B	1377	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	90	2211	44
TACTTCTAGCGG _A_Concatenation CTACGTGGCCCC _B	1378	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	90	2211	86
						TACTTCTAGCGG _A_Concatenation AGAGTGCGCTCT _B	1379	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	90	2211	14
TACTTCTAGCGG _A_Concatenation ACTTGATGGTTT _B	1380	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	90	2211	77
						TACTTCTAGCGG _A_Concatenation CCCTATGTTCTA _B	1381	TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	90	2211	15
ACTCGTGTTGTC _A_Concatenation AGAGTGCGCTCT _B	1382	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	91	2211	14
						ACTCGTGTTGTC _A_Concatenation ATGACCCCTTGT _B	1383	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	91	2211	17
ACTCGTGTTGTC _A_Concatenation GAGATTGTGTCC _B	1384	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	91	2211	64
						ACTCGTGTTGTC _A_Concatenation ACTTGATGGTTT _B	1385	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	91	2211	77
ACTCGTGTTGTC _A_Concatenation ATAACTCCACGC _B	1386	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	91	2211	44
						ACTCGTGTTGTC _A_Concatenation CTACGTGGCCCC _B	1387	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	91	2211	86
ACTCGTGTTGTC _A_Concatenation CCCTATGTTCTA _B	1388	VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	91	2211	15
						ATTGTATCTAAC _A_Concatenation ATGACCCCTTGT _B	1389	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	92	2211	17
ATTGTATCTAAC _A_Concatenation ACTTGATGGTTT _B	1390	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	92	2211	77
						ATTGTATCTAAC _A_Concatenation CTACGTGGCCCC _B	1391	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	92	2211	86
ATTGTATCTAAC _A_Concatenation GAGATTGTGTCC _B	1392	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	92	2211	64
						ATTGTATCTAAC _A_Concatenation ATAACTCCACGC _B	1393	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	92	2211	44
ATTGTATCTAAC _A_Concatenation AGAGTGCGCTCT _B	1394	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	92	2211	14
						ATTGTATCTAAC _A_Concatenation CCCTATGTTCTA _B	1395	VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	92	2211	15
AGGCTTCCCGCT _A_Concatenation ATGACCCCTTGT _B	1396	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	93	2211	17
						AGGCTTCCCGCT _A_Concatenation ATAACTCCACGC _B	1397	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	93	2211	44
AGGCTTCCCGCT _A_Concatenation ACTTGATGGTTT _B	1398	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	93	2211	77
						AGGCTTCCCGCT _A_Concatenation AGAGTGCGCTCT _B	1399	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	93	2211	14
AGGCTTCCCGCT _A_Concatenation CTACGTGGCCCC _B	1400	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	93	2211	86
						AGGCTTCCCGCT _A_Concatenation GAGATTGTGTCC _B	1401	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	93	2211	64
AGGCTTCCCGCT _A_Concatenation CCCTATGTTCTA _B	1402	VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIVGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	93	2211	15
						ATCTCTCAGTTC _A_Concatenation GAGATTGTGTCC _B	1403	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	94	2211	64
ATCTCTCAGTTC _A_Concatenation ATGACCCCTTGT _B	1404	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	94	2211	17
						ATCTCTCAGTTC _A_Concatenation AGAGTGCGCTCT _B	1405	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	94	2211	14
ATCTCTCAGTTC _A_Concatenation ATAACTCCACGC _B	1406	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	94	2211	44
						ATCTCTCAGTTC _A_Concatenation ACTTGATGGTTT _B	1407	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	94	2211	77
ATCTCTCAGTTC _A_Concatenation CTACGTGGCCCC _B	1408	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	94	2211	86
						ATCTCTCAGTTC _A_Concatenation CCCTATGTTCTA _B	1409	VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLKGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	94	2211	15
CACACCCGGCAG _A_Concatenation GAGATTGTGTCC _B	1410	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	95	2211	64
						CACACCCGGCAG _A_Concatenation CTACGTGGCCCC _B	1411	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	95	2211	86
CACACCCGGCAG _A_Concatenation ATGACCCCTTGT _B	1412	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	95	2211	17
						CACACCCGGCAG _A_Concatenation ACTTGATGGTTT _B	1413	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	95	2211	77
CACACCCGGCAG _A_Concatenation ATAACTCCACGC _B	1414	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	95	2211	44
						CACACCCGGCAG _A_Concatenation AGAGTGCGCTCT _B	1415	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	95	2211	14
CACACCCGGCAG _A_Concatenation CCCTATGTTCTA _B	1416	VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	95	2211	15
						AATCGATCCTAC _A_Concatenation ACTTGATGGTTT _B	1417	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	96	2211	77
AATCGATCCTAC _A_Concatenation CTACGTGGCCCC _B	1418	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	96	2211	86
						AATCGATCCTAC _A_Concatenation ATGACCCCTTGT _B	1419	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	96	2211	17
AATCGATCCTAC _A_Concatenation ATAACTCCACGC _B	1420	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	96	2211	44
						AATCGATCCTAC _A_Concatenation GAGATTGTGTCC _B	1421	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	96	2211	64
AATCGATCCTAC _A_Concatenation AGAGTGCGCTCT _B	1422	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	96	2211	14
						AATCGATCCTAC _A_Concatenation CCCTATGTTCTA _B	1423	VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	96	2211	15
GTTCCACGCCTG _A_Concatenation ACTTGATGGTTT _B	1424	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	97	2211	77
						GTTCCACGCCTG _A_Concatenation GAGATTGTGTCC _B	1425	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	97	2211	64
GTTCCACGCCTG _A_Concatenation ATAACTCCACGC _B	1426	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	97	2211	44
						GTTCCACGCCTG _A_Concatenation ATGACCCCTTGT _B	1427	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	97	2211	17
GTTCCACGCCTG _A_Concatenation CTACGTGGCCCC _B	1428	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	97	2211	86
						GTTCCACGCCTG _A_Concatenation AGAGTGCGCTCT _B	1429	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	97	2211	14
GTTCCACGCCTG _A_Concatenation CCCTATGTTCTA _B	1430	VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	97	2211	15
						CCGCCCTTATGT _A_Concatenation ACTTGATGGTTT _B	1431	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	98	2211	77
CCGCCCTTATGT _A_Concatenation AGAGTGCGCTCT _B	1432	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	98	2211	14
						CCGCCCTTATGT _A_Concatenation ATGACCCCTTGT _B	1433	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	98	2211	17
CCGCCCTTATGT _A_Concatenation CTACGTGGCCCC _B	1434	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	98	2211	86
						CCGCCCTTATGT _A_Concatenation GAGATTGTGTCC _B	1435	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	98	2211	64
CCGCCCTTATGT _A_Concatenation ATAACTCCACGC _B	1436	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	98	2211	44
						CCGCCCTTATGT _A_Concatenation CCCTATGTTCTA _B	1437	VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	98	2211	15
GGCACTGTCGAG _A_Concatenation AGAGTGCGCTCT _B	1438	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	99	2211	14
						GGCACTGTCGAG _A_Concatenation CTACGTGGCCCC _B	1439	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	99	2211	86
GGCACTGTCGAG _A_Concatenation ATAACTCCACGC _B	1440	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	99	2211	44
						GGCACTGTCGAG _A_Concatenation GAGATTGTGTCC _B	1441	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	99	2211	64
GGCACTGTCGAG _A_Concatenation ATGACCCCTTGT _B	1442	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	99	2211	17
						GGCACTGTCGAG _A_Concatenation ACTTGATGGTTT _B	1443	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	99	2211	77
GGCACTGTCGAG _A_Concatenation CCCTATGTTCTA _B	1444	YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDAGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	99	2211	15
						CAACGCATGCCT _A_Concatenation ATGACCCCTTGT _B	1445	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV	100	2211	17
CAACGCATGCCT _A_Concatenation CTACGTGGCCCC _B	1446	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL	100	2211	86
						CAACGCATGCCT _A_Concatenation GAGATTGTGTCC _B	1447	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP	100	2211	64
CAACGCATGCCT _A_Concatenation AGAGTGCGCTCT _B	1448	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGCPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP	100	2211	14
						CAACGCATGCCT _A_Concatenation ATAACTCCACGC _B	1449	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML	100	2211	44
CAACGCATGCCT _A_Concatenation ACTTGATGGTTT _B	1450	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGRPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR	100	2211	77
						CAACGCATGCCT _A_Concatenation CCCTATGTTCTA _B	1451	YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLSGSGGSGGSGGSGDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL	100	2211	15

The peptide amino acid sequence comprising the combination of "x" shows a stop codon at that position that prevents translation of the remainder of the listed sequence encoded by the nucleic acid.

Heterologous endonucleases

In some embodiments, the engineered gene effector of the present disclosure comprises a polypeptide coupled to a heterologous endonuclease (e.g., an enzymatically active Cas protein, an enzymatically inactive Cas protein, etc.). In some embodiments, the engineered gene effectors disclosed herein, or proteins comprising engineered gene effectors (e.g., proteins comprising engineered gene effectors coupled to heterologous endonucleases), may be referred to as effector moieties. The engineered gene effector and the heterologous endonuclease may be coupled to each other, e.g., directly or indirectly (e.g., via a linker). For example, the engineered gene effector and the heterologous endonuclease may be fused to each other, e.g., directly or indirectly (e.g., via a linker). In another example, the engineered gene effector and the heterologous endonuclease may be non-covalently coupled to each other, e.g., by ionic bonding, hydrogen bonding, oligomerization or dimerization domain-mediated interactions, and the like. In some cases, the engineered gene effector and the heterologous endonuclease may be part of a single polypeptide molecule (e.g., a chimeric or fusion polypeptide).

In a variety of organisms, including a variety of mammals, animals, plants, microorganisms, and yeasts, the CRISPR/Cas system (e.g., modified and/or unmodified) can be used as a genome engineering tool, or can be modified to direct the specific binding of an engineered protein to a target locus disclosed herein. The CRISPR/Cas system may comprise a guide nucleic acid (e.g., guide RNA (gRNA)) complexed with a Cas protein for targeted regulation of gene expression and/or activity or nucleic acid binding. RNA-guided Cas proteins (e.g., cas nucleases, such as Cas9 nucleases) can specifically bind target polynucleotides (e.g., DNA) in a sequence-dependent manner. Cas proteins, if having nuclease activity, can cleave DNA.

Non-limiting examples of heterologous endonucleases disclosed and used herein include, but are not limited to, CRISPR-associated (Cas) proteins or Cas nucleases, including type I CRISPR-associated (Cas) polypeptides, type II CRISPR-associated (Cas) polypeptides, type III CRISPR-associated (Cas) polypeptides, type IV CRISPR-associated (Cas) polypeptides, type V CRISPR-associated (Cas) polypeptides, and type VI CRISPR-associated (Cas) polypeptides, zinc Finger Nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), meganucleases (meganucleases), RNA Binding Proteins (RBPs), CRISPR-associated RNA binding proteins, recombinases, invertases, argonaute (Ago) proteins (e.g., prokaryotic Argonaute (pAgo), archaebacterium Argonaute (aAgo), or eukaryotic Argonaute (eAgo)), or any derivatives thereof, any variants thereof, and any fragments thereof.

In some embodiments, the heterologous endonucleases disclosed herein can be nuclease deficient. In some embodiments, the heterologous endonuclease may be a nuclease-deleted (nucleic-null) DNA binding protein that does not induce transcriptional activation or repression of the target DNA sequence unless it is present in the complex with one or more engineered gene effectors of the present disclosure. In some embodiments, the heterologous endonuclease may be a nuclease-deleted DNA-binding protein that can induce transcriptional activation or repression of the target DNA sequence (e.g., which can be altered or enhanced by the presence of an engineered gene effector provided herein). In some cases, the Cas protein is mutated and/or modified to produce a nuclease-deficient protein or a protein having reduced nuclease activity relative to a wild-type Cas protein. Nuclease-deficient proteins may retain the ability to bind DNA, but may lack or have reduced nucleic acid cleavage activity.

In some embodiments, the heterologous endonucleases disclosed herein can be RNA nucleases, such as engineered (e.g., programmable or targetable) RNA nucleases. In some embodiments, the heterologous endonuclease disclosed herein can be a nuclease-deleted RNA-binding protein that does not induce transcriptional activation or repression of the target RNA sequence unless it is present in a complex with one or more engineered gene effectors of the present disclosure. In some embodiments, the heterologous endonucleases disclosed herein can be nuclease deleted RNA binding proteins that can induce transcriptional activation or repression of a target RNA sequence (e.g., which can be altered or enhanced by the presence of an engineered gene effector provided herein).

In some embodiments, the heterologous endonuclease may be a nucleic acid-guided targeting system. In some embodiments, the heterologous endonuclease may be a DNA-guided targeting system. In some embodiments, the heterologous endonuclease may be an RNA-guided targeting system. The nucleic acid-guided targeting system can comprise and utilize, for example, a guide nucleic acid sequence that facilitates specific binding of the CRISPR-Cas system (e.g., a nuclease-deficient form thereof, such as dCas9 or dCas 14) to a target gene (e.g., a target endogenous gene) or target gene regulatory sequence. For example, the target gene may be any of the genes listed in table 6, and the target gene regulatory sequence may be operably coupled to any of the genes listed in table 6. Binding specificity may be determined by using a guide nucleic acid (e.g., single guide RNA (sgRNA) or a portion thereof). In some embodiments, the use of different sgrnas allows the compositions, combinations, systems, and methods of the present disclosure to be used with (e.g., targeted to) different target genes (e.g., target endogenous genes) or target gene regulatory sequences.

In some embodiments, prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR related) systems, such as class II CRISPR-Cas systems (e.g., cas9 and Cpfl) can be reused as tools in the compositions, combinations, systems, and methods of the present disclosure to regulate gene expression, epigenomic editing, and chromatin cyclization. In some embodiments, nuclease-inactivated Cas (dCas) protein complexed with a heterologous gene effector can allow for modulation of expression of a target gene (e.g., a target endogenous gene) adjacent to the dCas binding site.

Any suitable CRISPR/Cas system may be used. CRISPR/Cas systems can be referred to using a variety of naming schemes. The CRISPR/Cas system can be a type I, type II, type III, type IV, type V, type VI system, or any other suitable CRISPR/Cas system. As used herein, a CRISPR/Cas system can be a class 1, a class 2, or any other suitable classification of CRISPR/Cas system. The determination of class 1 or class 2 may be based on the gene encoding the effector module. Class 1 systems typically have a multi-subunit crRNA effector complex, while class 2 systems typically have a single protein (e.g., cas9, cpfl, C2C1, C2, C2C 3) or crRNA effector complex. Class 1 CRISPR/Cas systems can use complexes of multiple Cas proteins to achieve regulation. Class 1 CRISPR/Cas systems may comprise, for example, type I (e.g., I, IA, IB, IC, ID, IE, IF or IU), type III (e.g., III, IIIA, IIIB, IIIC or IIID), and type IV (e.g., IV, IVA or IVB) CRISPR/Cas types. Class 2 CRISPR/Cas systems can use a single large Cas protein to achieve regulation. Class 2 CRISPR/Cas systems may comprise, for example, type II (e.g., II, IIA, or IIB) and type V CRISPR/Cas types. CRISPR systems can be complementary to each other and/or can provide trans-functional units to facilitate CRISPR locus targeting.

When the heterologous endonuclease comprises a Cas protein or a derivative thereof, the Cas protein or derivative thereof may be a class 1 or class 2 Cas protein. The Cas protein may be a type I, type II, type III, type IV, type V Cas protein or a type VI Cas protein. The Cas protein may comprise one or more domains. Non-limiting examples of domains include guide recognition and/or binding domains, nuclease domains (e.g., DNase or RNase domains, ruvC or HNH), DNA binding domains, RNA binding domains, helicase domains, protein-protein interaction domains, or dimerization domains. The guide recognition and/or binding domains may interact with the guide. The nuclease domain may comprise catalytic activity for nucleic acid cleavage. The nuclease domain may lack catalytic activity to prevent nucleic acid cleavage. The Cas protein may be a chimeric Cas protein or a fragment thereof fused to other proteins or polypeptides. The Cas protein may be a chimera of multiple Cas proteins, e.g., comprising domains from different Cas proteins.

Non-limiting examples of Cas proteins include c2c1、C2c2、c2c3、Cas1、Cas1B、Cas2、Cas3、Cas4、Cas5、Cas5e（CasD）、Cash、Cas6e、Cas6f、Cas7、Cas8a、Cas8a1、Cas8a2、Cas8b、Cas8c、Cas9（Csn1 or Csx12）、Cas10、Cas10d、CasF、CasG、CasH、Cpfl、Csyl、Csy2、Csy3、Cse1（CasA）、Cse2（CasB）、Cse3（CasE）、Cse4（CasC）、Csc1、Csc2、Csa5、Csn2、Csm2、Csm3、Csm4、Csm5、Csm6、Cmrl、Cmr3、Cmr4、Cmr5、Cmr6、Csb1、Csb2、Csb3、Csx17、Csx14、Csx10、Csx16、CsaX、Csx3、Csx1、Csx15、Csf1、Csf2、Csf3、Csf4、Cul966、Cas13a、Cas13b、Cas13c、Cas13d、Cas13X or Cas13Y, as well as homologs or modified versions thereof.

In some embodiments, the Cas protein disclosed herein may not be and need not be Cas9 or Cas12a. The Cas proteins disclosed herein may have smaller dimensions compared to Cas9 or Cas12a. The Cas proteins disclosed herein may be derived from Un1Cas12f1. In some embodiments, a heterologous endonuclease may comprise an amino acid sequence that has at least or at most about 50%, at least or at most about 55%, at least or at most about 60%, at least or at most about 65%, at least or at most about 70%, at least or at most about 75%, at least or at most about 80%, at least or at most about 85%, at least or at most about 90%, at least or at most about 91%, at least or at most about 92%, at least or at most about 93%, at least or at most about 94%, at least or at most about 95%, at least or at most about 96%, at least or at most about 97%, at least or at most about 98%, at least or at least about 99% or about 100% sequence identity to the polypeptide sequence of SEQ ID NO 2222 (e.g., casMini). In some embodiments, a heterologous endonuclease may comprise an amino acid sequence that has at least or at most about 50%, at least or at most about 55%, at least or at most about 60%, at least or at most about 65%, at least or at most about 70%, at least or at most about 75%, at least or at most about 80%, at least or at most about 85%, at least or at most about 90%, at least or at most about 91%, at least or at most about 92%, at least or at most about 93%, at least or at most about 94%, at least or at most about 95%, at least or at most about 96%, at least or at most about 97%, at least or at most about 98%, at least or at least about 99% or about 100% sequence identity to the polypeptide sequence (e.g., dCasMini) of SEQ ID NO 2231. As disclosed herein, SEQ ID No. 2222 encodes the polypeptide sequence of Un1Cas12f1. As disclosed herein, SEQ ID No. 2231 encodes an engineered variant of Un1Cas12f1 with reduced nuclease activity. As disclosed herein, SEQ ID No. 2232 encodes a non-limiting example of a Cas12f variant suitable for use in the systems, compositions, combinations, and methods of the present disclosure. In some embodiments, cas12f variants disclosed herein may comprise an amino acid sequence that is at least or at least about 50%, at least or at least about 60%, at least or at least about 70%, at least or at least about 75%, at least or at least about 80%, at least or at least about 85%, at least or at least about 90%, at least or at least about 95%, at least or at least about 96%, at least or at least about 97%, at least or at least about 98%, at least or at least about 99%, or substantially about 100% identical to the polypeptide sequence of SEQ ID No. 2232.

SEQ ID NO: 2222(Un1Cas12f1)

1 MAKNTITKTL KLRIVRPYNS AEVEKIVADE KNNREKIALE KNKDKVKEAC

51 SKHLKVAAYC TTQVERNACL FCKARKLDDK FYQKLRGQFP DAVFWQEISE

101 IFRQLQKQAA EIYNQSLIEL YYEIFIKGKG IANASSVEHY LSDVCYTRAA

151 ELFKNAAIAS GLRSKIKSNF RLKELKNMKS GLPTTKSDNF PIPLVKQKGG

201 QYTGFEISNH NSDFIIKIPF GRWQVKKEID KYRPWEKFDF EQVQKSPKPI

251 SLLLSTQRRK RNKGWSKDEG TEAEIKKVMN GDYQTSYIEV KRGSKIGEKS

301 AWMLNLSIDV PKIDKGVDPS IIGGIDVGVK SPLVCAINNA FSRYSISDND

351 LFHFNKKMFA RRRILLKKNR HKRAGHGAKN KLKPITILTE KSERFRKKLI

401 ERWACEIADF FIKNKVGTVQ MENLESMKRK EDSYFNIRLR GFWPYAEMQN

451 KIEFKLKQYG IEIRKVAPNN TSKTCSKCGH LNNYFNFEYR KKNKFPHFKC

501 EKCNFKENAD YNAALNISNP KLKSTKEEP

2231 (Inactivated nuclease variant of Un1Cas12f 1)

1 MAKNTITKTL KLRIVRPYNS AEVEKIVADE KNNREKIALE KNKDKVKEAC

51 SKHLKVAAYC TTQVERNACL FCKARKLDDK FYQKLRGQFP DAVFWQEISE

101 IFRQLQKQAA EIYNQSLIEL YYEIFIKGKG IANASSVEHY LSRVCYRRAA

151 ELFKNAAIAS GLRSKIKSNF RLKELKNMKS GLPTTKSDNF PIPLVKQKGG

201 QYTGFEISNH NSDFIIKIPF GRWQVKKEID KYRPWEKFDF EQVQKSPKPI

251 SLLLSTQRRK RNKGWSKDEG TEAEIKKVMN GDYQTSYIEV KRGSKICEKS

301 AWMLNLSIDV PKIDKGVDPS IIGGIAVGVR SPLVCAINNA FSRYSISDND

351 LFHFNKKMFA RRRILLKKNR HKRAGHGAKN KLKPITILTE KSERFRKKLI

401 ERWACEIADF FIKNKVGTVQ MENLESMKRK EDSYFNIRLR GFWPYAEMQN

451 KIEFKLKQYG IEIRKVAPNN TSKTCSKCGH LNNYFNFEYR KKNKFPHFKC

501 EKCNFKENAA YNAALNISNP KLKSTKERP

SEQ ID NO. 2232 (Cas 12f variant)

MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIAGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP

In some embodiments, the amino acid sequences of the heterologous endonucleases disclosed herein can be mutated and/or modified to produce nuclease-deficient proteins or proteins having reduced nuclease activity relative to wild-type Cas proteins. Nuclease-deficient proteins may retain the ability to bind to a target gene (e.g., DNA), but may lack or have reduced nucleic acid cleavage activity. In some embodiments, the heterologous endonuclease can exhibit reduced nuclease activity (e.g., nuclease-deficient or nuclease-deleted) compared to wild-type Un1Cas12f 1. The reduced nuclease activity can be at most about 95%, at most about 90%, at most about 80%, at most about 70%, at most about 60%, at most about 50%, at most about 40%, at most about 30%, at most about 20%, at most about 10%, at most about 5%, at most about 1%, at most about 0.5%, at most about 0.1% or less of wild-type Un1Cas12f 1.

In some cases, the Cas protein provided herein may not be a Cas14 protein.

The Cas protein or fragment or derivative thereof may be from any suitable organism. Non-limiting examples include Streptococcus pyogenes (Streptococcus pyogenes), streptococcus thermophilus (Streptococcus thermophilus), streptococcus sp, staphylococcus aureus (Staphylococcus aureus), north Amycolatopsis darunae (Nocardiopsis dassonvillei), streptomyces roseoflotates (Streptomyces PRISTINAE SPIRALIS), streptococcus sp, Streptomyces viridochromogenes (Streptomyces viridochromo genes), streptomyces viridochromogenes (Streptomyces viridochromogenes), streptomyces roseoflash (Streptosporangium roseum), streptomyces roseoflash (Streptosporangium roseum), alicyclobacHlus acidocaldarius, bacillus pseudomycoides (Bacillus pseudomycoides), Bacillus selenitireducens, exiguobacterium sibiricum, lactobacillus delbrueckii, lactobacillus salivarius 、Microscilla marina、Burkholderiales bacterium、Polaromonas nap hthalenivorans、Polaromonas sp.、Crocosphaera watsonii、Cyanothece sp.、 Microcystis aeruginosa (Microcystis aeruginosa), pseudomonas aeruginosa （Pseudomonas aeruginosa）、Synechococcus sp.、Acetohalobium arabaticum、Ammonifex degensii、Caldicelulosiruptor becscii、Candidatus Desulforudis、 Clostridium botulinum (Clostridium botulinum), Clostridium difficile （Clostridium difficile）、Finegoldia magna、Natranaerobius thermophilus、Pelotomaculum thermopropionicum、 Acidophilic thiobacillus caldus (Acidithiobacillus caldus), acidothiobacillus ferrooxidans （Acidithiobacillus ferrooxidans）、Allochromatium vinosum、Marinobacter sp.、Nitrosococcus halophilus、Nitrosococcus watsoni、 Acidovorax facilis (Pseudoalteromonas haloplanktis), ktedonobacter racemifer, methanohalobium evestigatum, Anabaena variabilis (Anabaena variabilis), nodularia spumigena, nostoc (Nostoc sp.), arthrospira maxima (Arthrospira maxima), arthrospira platensis (Arthrospira platensis), arthrospira (Arthrospira sp.), lyngbya sp., microcystis prototheca (Microcoleus chthonoplastes), oscillatoria (oscilloria sp.), fusarium sp, Petrotoga mobilis, african Thermomyces (Thermosipho africanus), acaryochloris marina, leptotrichia shahii or FRANCISELLA NOVICIDA. In some aspects, the organism is streptococcus pyogenes (s. pyogenes). In some aspects, the organism is staphylococcus aureus (s. In some aspects, the organism is streptococcus thermophilus (s.

Cas proteins may be derived from a variety of bacterial species including, but not limited to Veillonella atypical, fusobacterium nucleatum (Fusobacterium nucleatum), filifactor alocis, solobacterium moorei, coprococcus catus, treponema pallidum (Treponema denticola), peptoniphilus duerdenii, catenibacterium mitsuokai, Streptococcus mutans (Streptococcus mutans), listeria innocens （Listeria innocua）、Staphylococcus pseudintermedius、Acidaminococcus intestine、Olsenella uli、Oenococcus kitaharae、 bifidobacterium bifidum (Bifidobacterium bifidum), lactobacillus rhamnosus (Lactobacillus rhamnosus), lactobacillus gasseri (Lactobacillus gasseri), finegoldia magna, mycoplasma mobile, Mycoplasma gallisepticum (Mycoplasma gallisepticum), mycoplasma ovipneumoniae (Mycoplasma ovipneumoniae), mycoplasma canis (Mycoplasma canis), mycoplasma synovium (Mycoplasma synoviae), mycobacterium rectum (Eubacterium rectale), streptococcus thermophilus (Streptococcus thermophilus), eubacterium dolichum, lactobacillus curvatus subspecies (Lactobacillus coryniformis subsp. Torquens), Ilyobacter polytropus, ruminococcus albus (Ruminococcus albus), acremonium muciniphilum (AKKERMANSIA MUCINIPHILA), acidothermus cellulolyticus, bifidobacterium longum (Bifidobacterium longum), bifidobacterium dentium, bacteroides fragilis (Bacteroides fragilis) of diphtheria bacillus （Corynebacterium diphtheria）、Elusimicrobium minutum、Nitratifractorsalsuginis、Sphaerochaeta globus、Fibrobacter succinogenes subsp. Succinogenes、, Carbon dioxide philic bacteria (Capnocytophaga ochracea), rhodopseudomonas palustris (Rhodopseudomonas palustris), prevotella micans, prevotella ruminicola, flavobacterium columniformis (Flavobacterium columnare), aminomonas paucivorans, rhodospirillum (Azospiralum) （Rhodospirillum rubrum）、Candidatus Puniceispirillum marinum、Verminephrobacter eiseniae、Ralstonia syzygii、Dinoroseobacter shibae、, azospiralum, Nitrobacter hamburgensis, rhizobium (Bradyrhizobium), wolinella succinogenes, campylobacter jejuni subspecies jejuni (Campylobacter jejuni subsp. Jejuni), helicobacter ferret (Helicobacter mustelae), bacillus cereus (Bacillus cereus), acidovorax ebreus, clostridium aerogenes (Clostridium perfringens), parvibaculum lavamentivorans, roseburia intestinalis, neisseria meningitidis (NEISSERIA MENINGITIDIS), pasteurella spinosad (Pasteurella multocida subsp. Multocida), sutterella wadsworthensis, proteobacterium, legionella pneumophila (Legionella pneumophila), Parasutterella excrementihominis, wolinella succinogenes or FRANCISELLA NOVICIDA.

Cas proteins used herein may be wild-type or modified forms of Cas proteins. The Cas protein may be an active variant, inactive variant or fragment of a wild-type or modified Cas protein. The Cas protein may comprise amino acid changes, such as deletions, insertions, substitutions, variants, mutations, fusions, chimeras, or any combination thereof, relative to the wild-type version of the Cas protein. The Cas protein may be a polypeptide having at least or at least about 5%, at least or at least about 10%, at least or at least about 20%, at least or at least about 30%, at least or at least about 40%, at least or at least about 50%, at least or at least about 60%, at least or at least about 70%, at least or at least about 80%, at least or at least about 90%, at least or at least about 91%, at least or at least about 92%, at least or at least about 93%, at least or at least about 94%, at least or at least about 95%, at least or at least about 96%, at least or at least about 97%, at least or at least about 98%, at least or at least about 99%, or 100% sequence identity or sequence similarity to the wild-type Cas protein. Cas proteins may be polypeptides having at most or at most about 5%, at most or at most about 10%, at most or at most about 20%, at most or at most about 30%, at most or at most about 40%, at most or at most about 50%, at most or at most about 60%, at most or at most about 70%, at most or at most about 80%, at most or at most about 90%, or at most about 100% sequence identity and/or sequence similarity to wild-type exemplary Cas proteins. The variant or fragment may comprise at least or at least about 5%, at least or at least about 10%, at least or at least about 20%, at least or at least about 30%, at least or at least about 40%, at least or at least about 50%, at least or at least about 60%, at least or at least about 70%, at least or at least about 80%, at least or at least about 90%, at least or at least about 91%, at least or at least about 92%, at least or at least about 93%, at least or at least about 94%, at least or at least about 95%, at least or at least about 96%, at least or at least about 97%, at least or at least about 98%, at least or at least about 99%, or 100% sequence identity or sequence similarity to the wild-type or modified Cas protein or a portion thereof. The variant or fragment may target a nucleic acid locus that is complexed with a guide nucleic acid, while lacking nucleic acid cleavage activity.

The Cas protein may comprise one or more nuclease domains, such as DNase domains. For example, the Cas9 protein may comprise a RuvC-like nuclease domain and/or an HNH-like 20 nuclease domain. In the nuclease-active form of Cas9, the RuvC domain and HNH domain can each cleave a different strand of double-stranded DNA, thereby creating a double-strand break in the DNA. Cas proteins may contain only one nuclease domain (e.g., cpfl contains a RuvC domain, but lacks an HNH domain). In some embodiments, the nuclease domain is absent. In some embodiments, the nuclease domain is present but inactive, or has reduced or minimal activity. In some embodiments, the nuclease domain is present and active.

One or more nuclease domains (e.g., ruvC or HNH) of the Cas protein may be deleted or mutated such that they are no longer functional or comprise reduced nuclease activity. For example, in Cas proteins (e.g., cas 9) comprising at least two nuclease domains, if one of the nuclease domains is deleted or mutated, the resulting Cas protein (referred to as a nickase) may produce a single-strand break, but not a double-strand break, at the CRISPR RNA (crRNA) recognition sequence within the double-stranded DNA. Such nicking enzymes may cleave either the complementary strand or the non-complementary strand, but may not cleave both simultaneously. If all nuclease domains of the Cas protein (e.g., both RuvC and HNH nuclease domains in Cas9 protein; ruvC nuclease domain in Cpfl protein) are deleted or mutated, the resulting Cas protein may have reduced or no ability to cleave both strands of double-stranded DNA. Examples of mutations that can convert Cas9 proteins to nickases are D10A (aspartic acid to alanine at position 10 of Cas 9) mutations in the RuvC domain of Cas9 from streptococcus pyogenes. Either H939A (histidine at amino acid 839 to alanine) or H840A (histidine at amino acid 840 to alanine) in the HNH domain of Cas9 from streptococcus pyogenes can convert Cas9 to a nickase. Examples of mutations that can convert Cas9 protein to dead Cas9 are the D10A (aspartic acid to alanine at position 10 of Cas 9) mutation in the RuvC domain of Cas9 from streptococcus pyogenes or the H939A (histidine to alanine at amino acid 839) or the H840A (histidine to alanine at amino acid 840) mutation in the HNH domain.

The nuclease-dead Cas protein (e.g., a protein derived from any Cas protein (e.g., un1Cas12f 1)) may comprise one or more mutations relative to a wild-type version of the protein. Mutations can cause no more than 90%, no more than 80%, no more than 70%, no more than 60%, no more than 50%, no more than 40%, no more than 30%, no more than 20%, no more than 10%, no more than 5%, or no more than 1% of the nucleic acid cleavage activity of one or more of the plurality of nucleic acid cleavage domains of the wild-type Cas protein. Mutations can cause one or more of the plurality of nucleic acid cleavage domains to retain the ability to cleave a complementary strand of a target nucleic acid, but reduce its ability to cleave a non-complementary strand of the target nucleic acid. Mutations can cause one or more of the plurality of nucleic acid cleavage domains to retain the ability to cleave a non-complementary strand of a target nucleic acid, but reduce its ability to cleave a complementary strand of the target nucleic acid. Mutations can cause one or more of the plurality of nucleic acid cleavage domains to lack the ability to cleave both the complementary strand and the non-complementary strand of the target nucleic acid. Residues to be mutated in the nuclease domain may correspond to one or more catalytic residues of the nuclease. For example, residues in wild-type exemplary streptococcus pyogenes Cas9 polypeptides, such as Asp10, his840, asn854, and Asn856, can be mutated to inactivate one or more of the plurality of nucleic acid cleavage domains (e.g., nuclease domains). Residues to be mutated in the Cas protein nuclease domain may correspond to Asp10, his840, asn854, and Asn856 residues in the wild-type streptococcus pyogenes Cas9 polypeptide, e.g., as determined by sequence and/or structural alignment.

As non-limiting examples, residues D10, G12, G17, E762, H840, N854, N863, H982, H983, a984, D986, and/or a987 (or corresponding mutations of any Cas protein) can be mutated. Such as D10A, G12A, G17A, E762A, H840A, N854A, N863A, H982A, H983A, A984A and/or D986A. Mutations other than alanine substitutions may be suitable.

The D10A mutation can be combined with one or more of the H840A, N854A or N856A mutations to produce a Cas9 protein (e.g., a death Cas9 protein) that substantially lacks DNA cleavage activity. The H840A mutation may be combined with one or more of the D10A, N854A or N856A mutations to produce a site-directed polypeptide that substantially lacks DNA cleavage activity. The N854A mutation may be combined with one or more of the H840A, D a or N856A mutations to produce a site-directed polypeptide that substantially lacks DNA cleavage activity. The N856A mutation may be combined with one or more of the H840A, N854A or D10A mutations to produce a site-directed polypeptide that substantially lacks DNA cleavage activity.

In some embodiments, the Cas protein is a class 2 Cas protein. In some embodiments, the Cas protein is a type II Cas protein. In some embodiments, the Cas protein is a Cas9 protein, a modified version of a Cas9 protein, or is derived from a Cas9 protein. For example, cas9 proteins lacking cleavage activity. In some embodiments, the Cas9 protein is a Cas9 protein from streptococcus pyogenes (e.g., swissProt accession Q99ZW 2). In some embodiments, the Cas9 protein is Cas9 from staphylococcus aureus (e.g., swissProt accession number J7RUA 5). In some embodiments, the Cas9 protein is a modified version of a Cas9 protein from streptococcus pyogenes or staphylococcus aureus. In some embodiments, the Cas9 protein is derived from a Cas9 protein from streptococcus pyogenes or staphylococcus aureus. For example, a streptococcus pyogenes or staphylococcus aureus Cas9 protein that lacks cleavage activity.

In some embodiments, cas9 may generally refer to a polypeptide having at least or at least about 5%, at least or at least about 10%, at least or at least about 20%, at least or at least about 30%, at least or at least about 40%, at least or at least about 50%, at least or at least about 60%, at least or at least about 70%, at least or at least about 80%, at least or at least about 90%, or about 100% sequence identity and/or sequence similarity to a wild-type exemplary Cas9 polypeptide (e.g., cas9 from streptococcus pyogenes). In some embodiments, cas9 may refer to a polypeptide having up to about 5%, up to about 10%, up to about 20%, up to about 30%, up to about 40%, up to about 50%, up to about 60%, up to about 70%, up to about 80%, up to about 90%, or about 100% sequence identity and/or sequence similarity with a wild-type Cas9 polypeptide (e.g., from streptococcus pyogenes). Cas9 may refer to a wild-type or modified form of Cas9 protein, which may comprise amino acid changes, such as deletions, insertions, substitutions, variants, mutations, fusions, chimeras, or any combination thereof.

The Cas protein may comprise an amino acid sequence having at least or at least about 5%, at least or at least about 10%, at least or at least about 20%, at least or at least about 30%, at least or at least about 40%, at least or at least about 50%, at least or at least about 60%, at least or at least about 70%, at least or at least about 80%, at least or at least about 90%, at least or at least about 91%, at least or at least about 92%, at least or at least about 93%, at least or at least about 94%, at least or at least about 95%, at least or at least about 96%, at least or at least about 97%, at least or at least about 98%, at least or at least about 99%, or 100% sequence identity or sequence similarity to a nuclease domain (e.g., ruvC domain or HNH domain) of the wild-type Cas protein.

Cas proteins, variants or derivatives thereof, may be modified to enhance the modulation of gene expression by the compositions, combinations, systems and methods of the present disclosure, e.g., as part of the complexes disclosed herein. Cas proteins may be modified to increase or decrease nucleic acid binding affinity, nucleic acid binding specificity, enzymatic activity, and/or binding to other factors (e.g., heterodimerization or oligomerization domains), as well as to induce ligands. Cas proteins may also be modified to alter any other activity or property of the protein, such as stability. For example, one or more nuclease domains of the Cas protein may be modified, deleted, or inactivated, or the Cas protein may be truncated to remove domains that are not necessary for the desired function of the protein or complex. Cas proteins may be modified to modulate (e.g., enhance or reduce) the activity of the Cas protein to regulate gene expression by the presently disclosed complexes comprising heterologous gene effectors.

For example, the Cas protein can be coupled (e.g., fused, covalently coupled, or non-covalently coupled) to a heterologous gene effector (e.g., an epigenetic modification domain, a transcriptional activation domain, and/or a transcriptional repression domain). Cas proteins can be coupled (e.g., fused, covalently coupled, or non-covalently coupled) to an oligomerization or dimerization domain (e.g., a heterodimerization domain) disclosed herein. Cas proteins may be coupled (e.g., fused, covalently coupled, or non-covalently coupled) to heterologous polypeptides that provide increased or decreased stability. Cas proteins may be coupled (e.g., fused, covalently coupled, or non-covalently coupled) to sequences that can promote degradation of the Cas protein or a complex containing the Cas protein, e.g., a down-resolution stator, such as an inducible down-resolution stator (e.g., auxin-inducible).

Cas proteins may be coupled (e.g., fused, covalently coupled, or non-covalently coupled) to any suitable number of partners, such as at least 1, at least 2, at least 3, at least 4, or at least 5, at least 6, at least 7, or at least 8 partners. In some embodiments, cas proteins of the present disclosure are coupled (e.g., fused, covalently coupled, or non-covalently coupled) to at most 2, at most 3, at most 4, at most 5, at most 6, at most 7, at most 8, or at most 10 partners. In some embodiments, the Cas proteins of the present disclosure are coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 1-5, 1-4, 1-3, 1-2, 2-5, 2-4, 2-3, 3-5, 3-4, or 4-5 partners. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 1 partner. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 2 partners. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 3 partners. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 4 partners. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 5 partners. In some embodiments, the Cas protein of the present disclosure is coupled (e.g., fused, covalently coupled, or non-covalently coupled) to 6 partners.

The Cas protein may be a fusion protein. The fused domain or heterologous polypeptide may be located at the N-terminus, C-terminus, or inside the Cas protein.

Cas proteins may be provided in any form. For example, the Cas protein may be provided in the form of a protein, such as Cas protein alone, or Cas protein complexed with a guide nucleic acid to ribonucleoprotein. Cas proteins may be provided in a complex form, e.g., complexed with a guide nucleic acid and/or one or more heterologous gene effectors of the present disclosure. Cas proteins, such as RNAs (e.g., messenger RNAs (mrnas)), or DNAs, may be provided in the form of nucleic acids encoding Cas proteins. The nucleic acid encoding the Cas protein may be codon optimized for efficient translation into the protein in a particular cell or organism.

The nucleic acid encoding the Cas protein, fragment or derivative thereof may be stably integrated into the cell genome. The nucleic acid encoding the Cas protein may be operably linked to a promoter, e.g., a promoter that is constitutively or inducible in the cell. The nucleic acid encoding the Cas protein may be operably linked to a promoter in an expression construct. The expression construct may include any nucleic acid construct capable of directing expression of a gene of interest or other nucleic acid sequence of interest (e.g., cas gene), and such nucleic acid sequence of interest may be transferred to a target cell.

In some embodiments, the Cas protein, variant or derivative thereof is a nuclease-dead Cas (dCas) protein. The death Cas protein may be a protein lacking nucleic acid cleavage activity.

The Cas protein may comprise a modified form of the wild-type Cas protein. The modified form of the wild-type Cas protein may comprise an amino acid change (e.g., a deletion, insertion, or substitution) that reduces the nucleic acid cleavage activity of the Cas protein. For example, a modified form of Cas protein may have no more than 90%, no more than 80%, no more than 70%, no more than 60%, no more than 50%, no more than 40%, no more than 30%, no more than 20%, no more than 10%, no more than 5%, or no more than 1% of the nucleic acid cleavage activity of a wild-type Cas protein (e.g., cas9 from streptococcus pyogenes). The modified form of Cas protein may not have substantial nucleic acid cleavage activity. When the Cas protein is a modified form that does not have substantial nucleic acid cleavage activity, it may be referred to as enzymatically inactive, "inactive" and/or "dead" (abbreviated as "d"). The death Cas protein (e.g., dCas or dCas 9) can bind to the target polynucleotide, but may not cleave or minimally cleave the target polynucleotide. In some aspects, the death Cas protein is a death Cas9 protein.

The dCas9 polypeptide can bind to a single guide RNA (sgRNA) to activate or repress transcription of a target gene (e.g., a target endogenous gene), e.g., to a heterologous gene effector as disclosed herein. The sgrnas can be introduced into cells expressing Cas or guide portion components of the present disclosure. In some cases, such cells can comprise one or more different sgrnas that target the same target gene (e.g., target endogenous gene) or target gene regulatory sequence. In other cases, the sgrnas target different nucleic acids in the cell (e.g., different target genes, different target gene regulatory sequences, or different sequences within the same target genes or target gene regulatory sequences).

In some embodiments, the engineered gene effector comprises a polypeptide coupled to a heterologous endonuclease, wherein the heterologous endonuclease has a length of 450, 460, 470, 480, 490, 500, 520, 540, 560, 580, 600, 620, 640, 660, 680, or 700 amino acids, or optionally, the heterologous endonuclease has a length within a range defined by any two of the foregoing values (e.g., 450-700 amino acids, 480-600 amino acids, 500-530 amino acids, 500-600 amino acids, etc.). In some embodiments, the engineered gene effector comprises a polypeptide coupled to a heterologous endonuclease, wherein the heterologous endonuclease is a Cas protein and is 450, 460, 470, 480, 490, 500, 520, 540, 560, 580, 600, 620, 640, 660, 680, or 700 amino acids in length, or optionally, the Cas protein is within a range of any two of the foregoing values (e.g., 450-700 amino acids, 480-600 amino acids, 500-530 amino acids, 500-600 amino acids, etc.).

In some embodiments, the engineered gene effector comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the heterologous endonuclease comprises any of the amino acid sequences listed in table 7. In some embodiments, the engineered gene effector comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOs 2222-2422. In some embodiments, the engineered gene effector comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the heterologous endonuclease comprises an amino acid sequence that is, at least or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any of SEQ ID NOs 2222-2422, or optionally the heterologous endonuclease comprises a percent identity (e.g., 85% -100%) within a range defined by any two of the foregoing values for any of SEQ ID NOs 2222-2422, 90% -100%, 95% -100%, 98% -100%, etc.). In some embodiments, the engineered gene effector comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOs 2222-2422. In some embodiments, the engineered gene effector comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the polypeptide comprises a first peptide comprising any of the sequences provided in table 3 and a second peptide heterologous to the first peptide and comprising any of the sequences provided in table 3, wherein the heterologous endonuclease comprises a polypeptide that is, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, a polypeptide that is heterologous to any of SEQ ID NOs 2222-2422 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 2222-2422. In some embodiments, the engineered gene effector comprises any one of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the polypeptide comprises a first peptide comprising any one of the sequences provided in table 3 and a second peptide heterologous to the first peptide and comprising any one of the sequences provided in table 3, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of the SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide, wherein the heterologous endonuclease comprises a polypeptide having a sequence of any one of SEQ ID NOs 2222-2422 About, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical amino acid sequence, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOS 2222-2422. In some embodiments, the engineered gene effector comprises a polypeptide having a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide comprises a sequence that is about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any of SEQ ID NOs 75, 4, 40, and 77, or optionally the first peptide comprises a percent identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98-100%, etc.), the second peptide comprising a sequence that is identical to any one of SEQ ID NOs 64, 44, 77, 17, and 96, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the second peptide comprising a percentage of identity (e.g., 85% -100%, 85% to 100%, 90% -100%, 95% -100%, 98% -100%, etc.), wherein the polypeptide is coupled to a heterologous endonuclease, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise permutations of the SEQ ID NOs of the first and second peptides set forth in table a, wherein the heterologous endonuclease comprises a polypeptide having, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, a sequence which is identical to any one of SEQ ID NOs 2222-2422 97%, 98%, 99% or 100% identical, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 2222-2422. In some embodiments, the engineered gene effector comprises a polypeptide having a sequence that is, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, or optionally, the first peptide comprises a percentage of identity (e.g., 85% -100%, 85% >, 100% >, 90% -100%, 95% -100%, 98% -100%, etc.), wherein the polypeptide is coupled to a heterologous endonuclease comprising an amino acid sequence that is, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any of SEQ ID NOs 2222-2422, or optionally, a heterologous endonuclease comprising a percent identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98% -100%, etc.).

The engineered gene effector polypeptide may be coupled to the heterologous endonuclease in any suitable manner. In some embodiments, the heterologous endonuclease is fused to a heterologous endonuclease (e.g., a Cas protein). In some embodiments, the engineered gene effector comprises a polypeptide coupled to a heterologous endonuclease, wherein the polypeptide is fused to the heterologous endonuclease. In some embodiments, the engineered gene effector polypeptide is coupled to the C-terminus of a heterologous endonuclease. In some embodiments, the engineered gene effector comprises a polypeptide coupled to a heterologous endonuclease, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease. In some embodiments, the engineered gene effector comprises a polypeptide coupled to a heterologous endonuclease, wherein the heterologous endonuclease is a Cas protein, and wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease. In some embodiments, the engineered gene effector is coupled to the heterologous endonuclease through a linker. Any suitable linker (such as those described herein) may be used to couple the engineered gene effector to the heterologous endonuclease.

Fusion proteins comprising the engineered gene effector of the present disclosure, and a heterologous endonuclease coupled to or fused to a polypeptide of the engineered gene effector are also provided. In some embodiments, the fusion protein comprises an engineered gene effector, and a heterologous endonuclease coupled to or fused to the polypeptide. In some embodiments, the fusion protein comprises an engineered gene effector, and a heterologous endonuclease coupled to or fused to the polypeptide, wherein the heterologous endonuclease is a Cas protein. The fusion protein may comprise any suitable engineered gene effector, e.g., any of the engineered gene effectors described herein, e.g., comprising a first peptide of 75-95 amino acids in length comprising the sequence of any one of SEQ ID NOs 3-100 or variants at least 85% identical thereto, and a second peptide of 75-95 amino acids in length, which is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOs 3-100 or variants at least 85% identical thereto. The fusion protein can comprise any suitable heterologous endonuclease, e.g., any of the heterologous endonucleases or Cas proteins described herein, e.g., a heterologous endonuclease having the amino acid sequence of any of SEQ ID NOs 2222-2422 or a sequence at least 85% identical thereto. The engineered gene effector may be coupled or fused to the heterologous endonuclease in any suitable manner, for example, by a linker as described herein. The engineered gene effector fusion polypeptide may be located at the N-terminus, C-terminus, or within the heterologous endonuclease.

In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector described herein, e.g., an engineered gene effector comprising a polypeptide comprising a first peptide that is 75-95 amino acids in length and comprises the sequence of any one of SEQ ID NOs 3-100 or a variant at least 85% identical thereto, and a second peptide that is 75-95 amino acids in length and is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOs 3-100 or a variant at least 85% identical thereto. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the N-terminus of the second peptide, wherein the first peptide is 75-95 amino acids in length and comprises the sequence of any one of SEQ ID NOs 3-100 (or variants at least 85% identical thereto), the second peptide is 75-95 amino acids in length, the second peptide is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOs 3-100 (or variants at least 85% identical thereto), wherein the SEQ ID NOs of the first peptide and the second peptide are selected in pairs according to any one of table 4. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide is 75-95 amino acids in length and comprises the sequence of any one of SEQ ID NOs 3-100 (or variants at least 85% identical thereto), the second peptide is 75-95 amino acids in length, the second peptide is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOs 3-100 (or variants at least 85% identical thereto), wherein the SEQ ID NOs of the first peptide and the second peptide are selected according to any one of the pairwise permutations of table 4, wherein the first peptide and the second peptide are linked by any one of the spacers (e.g., peptide linkers) described herein. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the N-terminus of the second peptide, wherein the first peptide is 85 amino acids in length and comprises the sequence of any one of SEQ ID NOs 3-33, 35-100, and the second peptide is 85 amino acids in length, the second peptide being heterologous to the first peptide and comprising the sequence of any one of SEQ ID NOs 3-33, 35-100, wherein the SEQ ID NOs of the first peptide and the second peptide are selected according to any one of the pairwise permutations of table 4, wherein the first peptide and the second peptide are linked by the sequence of SEQ ID NO 2211. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the N-terminus of the second peptide, wherein the first peptide is 85 amino acids in length and comprises the sequence of any one of SEQ ID NOS: 3-33, 35-100, and the second peptide being heterologous to the first peptide and comprising the sequence of SEQ ID NO: 34, wherein the SEQ ID NOS of the first peptide and the second peptide are selected according to any one of the pairwise permutations of Table 4, wherein the first peptide and the second peptide are linked by the sequence of SEQ ID NO: 2211. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the end of the second peptide N, wherein the first peptide comprises the sequence of SEQ ID NO: 34 and the second peptide is 85 amino acids in length, the second peptide being heterologous to the first peptide and comprising the sequence of any one of SEQ ID NOs: 3-33, 35-100, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of table 4 in a pairwise arrangement, wherein the first and second peptides are linked by the sequence of SEQ ID NO: 2211. the engineered gene effector may be fused or fused to the heterologous endonuclease in any suitable manner, for example, by a linker as described herein. In some embodiments, the fusion protein comprises any of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the polypeptide comprises a first peptide comprising any of the sequences provided in table 3 and a second peptide heterologous to the first peptide and comprising any of the sequences provided in table 3, wherein the heterologous endonuclease comprises a polypeptide which is, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% >, a polypeptide which is heterologous to any of SEQ ID NOs 2222-2422 94%, 95%, 96%, 97%, 98%, 99% or 100% identical amino acid sequence, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 2222-2422. In some embodiments, the fusion protein comprises any one of the polypeptides of the disclosure (e.g., having a first peptide and a second peptide as described herein) coupled to a heterologous endonuclease, wherein the polypeptide comprises a first peptide comprising any one of the sequences provided in table 3 and a second peptide heterologous to the first peptide and comprising any one of the sequences provided in table 3, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of the SEQ ID NOs of the first and second peptides listed in table 4, wherein the first peptide is at the N-terminus of the second peptide, wherein the heterologous endonuclease comprises a polypeptide having the sequence of any one of SEQ ID NOs 2222-2422, About, at least, or at most 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical amino acid sequence, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOS 2222-2422. In some embodiments, the fusion protein comprises a polypeptide having a first peptide and a second peptide, the first peptide being N-terminal to the second peptide, wherein the first peptide comprises a sequence that is, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any of SEQ ID NOs 75, 4, 40, and 77, or optionally the first peptide comprises a percentage of identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98% -100%, etc.), the second peptide comprising a sequence that is identical to any one of SEQ ID NOs 64, 44, 77, 17, and 96, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, or optionally, the second peptide comprising a percentage of identity (e.g., 85% -100%, 85% to 100%, 90% -100%, 95% -100%, 98% -100%, etc.), wherein the polypeptide is coupled to a heterologous endonuclease, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise permutations of the SEQ ID NOs of the first and second peptides set forth in table a, wherein the heterologous endonuclease comprises a polypeptide having, about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, a sequence which is identical to any one of SEQ ID NOs 2222-2422 97%, 98%, 99% or 100% identical, or optionally, a heterologous endonuclease comprises a sequence having a percent identity (e.g., 85% -100%, 90% -100%, 95% -100%, 98% -100%, etc.) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 2222-2422. In some embodiments, the fusion protein comprises a polypeptide having a sequence that is about, at least, or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107, or optionally, the first peptide comprises a percentage of identity (e.g., 85% -100%, v/v) within a range defined by any two of the foregoing values to any one of SEQ ID NOs 1085, 122, 1084, 653, 1099, and 1107 90% -100%, 95% -100%, 98% -100%, etc.), wherein the polypeptide is coupled to a heterologous endonuclease comprising an amino acid sequence that is, about, at least or up to 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to any of SEQ ID NOs 2222-2422, or optionally, a heterologous endonuclease comprising a percent identity (e.g., 85% -100% >, 90% -100%, 95% -100%, 98% -100%, etc.).

In some embodiments, the fusion protein comprises a heterologous endonuclease fused to any of the engineered gene effectors described herein by a linker (e.g., but not limited to any of SEQ ID NOS: 2211-2221). In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector described herein by a linker (e.g., but not limited to any one of SEQ ID NOS: 2211-2221), e.g., the engineered gene effector comprises a polypeptide comprising a first peptide having a length of 75-95 amino acids and comprising the sequence of any one of SEQ ID NOS: 3-100 or a variant at least 85% identical thereto and a second peptide having a length of 75-95 amino acids and being heterologous to the first peptide and comprising the sequence of any one of SEQ ID NOS: 3-100 or a variant at least 85% identical thereto. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the N-terminus of the second peptide, wherein the first peptide is 75-95 amino acids in length and comprises the sequence of any one of SEQ ID NOS: 3-100 (or a variant at least 85% identical thereto), the second peptide is 75-95 amino acids in length, the second peptide is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOS: 3-100 (or a variant at least 85% identical thereto), wherein the SEQ ID NOS of the first peptide and the second peptide are selected according to any one of the pairwise permutations of Table 4. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide is 75-95 amino acids in length and comprises the sequence of any one of SEQ ID NOs: 3-100 (or a variant at least 85% identical thereto), the second peptide is 75-95 amino acids in length, the second peptide is heterologous to the first peptide and comprises the sequence of any one of SEQ ID NOs: 3-100 (or a variant at least 85% identical thereto), wherein the SEQ ID NOs of the first peptide and the second peptide are selected according to any one of the pairwise arrangements in Table 4, wherein the first peptide and the second peptide are linked by any one of the linkers (e.g., peptide linkers) described herein. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being N-terminally positioned on the second peptide, wherein the first peptide is 85 amino acids in length and comprises the sequence of any one of SEQ ID NOs: 3-35-100, and the second peptide is 85 amino acids in length and is heterologous to the first peptide and comprises SEQ ID NOs: 3-100, by way of a linker (e.g., any one of SEQ ID NOs: 2211-2221), 35-100, wherein the SEQ ID NOs of the first and second peptides are selected according to any one of the pairwise arrangements of table 4, wherein the first and second peptides are linked by the sequence of SEQ ID NO: 2211. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being at the N-terminus of the second peptide, wherein the first peptide is 85 amino acids in length and comprises the sequence of any one of SEQ ID NOS: 3-33, 35-100, and the second peptide is heterologous to the first peptide and comprises the sequence of SEQ ID NO: 34, wherein the SEQ ID NOS of the first peptide and the second peptide are selected according to any one of the pairwise arrangements of SEQ ID NOS: 2211. In some embodiments, the fusion protein comprises a heterologous endonuclease fused to an engineered gene effector comprising a polypeptide comprising a first peptide and a second peptide, the first peptide being located at the N-terminus of the second peptide, wherein the first peptide comprises the sequence of SEQ ID NO: 34 and the second peptide is 85 amino acids in length, the second peptide being heterologous to the first peptide and comprising the sequence of any one of SEQ ID NO: 3-33, 35-100, wherein the SEQ ID NO of the first peptide and the second peptide are selected according to any one of Table 4 in a pairwise arrangement, wherein the first peptide and the second peptide are linked by the sequence of SEQ ID NO: 2211.

TABLE 7 amino acid sequences of heterologous endonuclease variants

Heterologous endonucleases	SEQ ID NO	Amino acid sequence
			Un1Cas12fl, "CasMini"	2222	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIDVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKLKSTKEEP
Un2Cas12fl	2223	MEVQKTVMKTLSLRILRPLYSQEIEKEIKEEKERRKQAGGTGELDGGFYKKLEKKHSEMFSFDRLNLLLNQLQREIAKVYNHAISELYIATIAQGNKSNKHYISSIVYNRAYGYFYNAYIALGICSKVEANFRSNELLTQQSALPTAKSDNFPIVLHKQKGAEGEDGGFRISTEGSDLIFEIPIPFYEYNGENRKEPYKWVKKGGQKPVLKLILSTFRRQRNKGWAKDEGTDAEIRKVTEGKYQVSQIEINRGKKLGEHQKWFANFSIEQPIYERKPNRSIVGGLDVGIRSPLVCAINNSFSRYSVDSNDVFKFSKQVFAFRRRLLSKNSLKRKGHGAAHKLEPITEMTEKNDKFRKKIIERWAKEVTNFFVKNQVGIVQIEDLSTMKDREDHFFNQYLRGFWPYYQMQTLIENKLKEYGIEVKRVQAKYTSQLCSNPNCRYWNNYFNFEYRKVNKFPKFKCEKCNLEISADYNAARNLSTPDIEKFVAKATKGINLPEK
			AsCas12f	2224	MIKVYRYEIVKPLDLDWKEFGTILRQLQQETRFALNKATQLAWEWMGFSSDYKDNHGEYPKSKDILGYTNVHGYAYHTIKTKAYRLNSGNLSQTIKRATDRFKAYQKEILRGDMSIPSYKRDIPLDLIKENISVNRMNHGDYIASLSLLSNPAKQEMNVKRKISVIIIVRGAGKTIMDRILSGEYQVSASQIIHDDRKNKWYLNISYDFEPQTRVLDLNKIMGIDLGVAVAVYMAFQHTPARYKLEGGEIENFRRQVESRRISMLRQGKYAGGARGGHGRDKRIKPIEQLRDKIANFRDTTNHRYSRYIVDMAIKEGCGTIQMEDLTNIRDIGSRFLQNWTYYDLQQKIIYKAEEAGIKVIKIDPQYTSQRCSECGNIDSGNRIGQAIFKCRACGYEANADYNAARNIAIPNIDKIIAESIK
Un1Cas12fl comprising an N-terminal deletion, e.g. amino acid residues 2-21	2225	MEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			Un1Cas12fl comprising an N-terminal deletion, e.g. amino acid residues 2-31	2226	MNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
Un1Cas12fl comprising a C-terminal deletion, e.g. amino acid residues 510-529	2227	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENA
			Un1Cas12fl comprising a C-terminal deletion, e.g. amino acid residues 500-529	2228	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFK
Un1Cas12fl comprising a partial N-terminal deletion, e.g. amino acid residues 47-66	2229	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			Un1Cas12fl comprising a partial N-terminal deletion, e.g. amino acid residues 47-71	2230	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALECKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
Inactivated nuclease variant of Un1Cas12fl, i.e., "dCasMini"	2231	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			Cas12f variants	2232	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIAGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
cA2	2233	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			Mi1Cas12f2	2234	MNMSKTTISVKLKIIDLSSEKKEFLDNYFNEYAKATTFCQLRIRRLLRNTHWLGKKEKSSKKWIFESGICDLCGENKELVNEDRNSGEPAKICKRCYNGRYGNQMIRKLFVSTKKREVQENMDIRRVAKLNNTHYHRIPEEAFDMIKAADTAEKRRKKNVEYDKKRQMEFIEMFNDEKKRAARPKKPNERETRYVHISKLESPSKGYTLNGIKRKIDGMGKKIERAEKGLSRKKIFGYQGNRIKLDSNWVRFDLAESEITIPSLFKEMKLRITGPTNVHSKSGQIYFAEWFERINKQPNNYCYLIRKTSSNGKYEYYLQYTYEAEVEANKEYAGCLGVDIGCSKLAAAVYYDSKNKKAQKPIEIFTNPIKKIKMRREKLIKLLSRVKVRHRRRKLMQLSKTEPIIDYTCHKTARKIVEMANTAKAFISMENLETGIKQKQQARETKKQKFYRNMFLFRKLSKLIEYKALLKGIKIVYVKPDYTSQTCSSCGADKEKTERPSQAIFRCLNPTCRYYQRDINADFNAAVNIAKKALNNTEVVTTLL
Mi2Cas12f2	2235	MPSETYITKTLSLKLIPSDEEKQALENYFITFQRAVNFAIDRIVDIRSSFRYLNKNEQFPAVCDCCGKKEKIMYVNISNKTFKFKPSRNQKDRYTKDIYTIKPNAHICKTCYSGVAGNMFIRKQMYPNDKEGWKVSRSYNIKVNAPGLTGTEYAMAIRKAISILRSFEKRRRNAERRIIEYEKSKKEYLELIDDVEKGKTNKIVVLEKEGHQRVKRYKHKNWPEKWQGISLNKAKSKVKDIEKRIKKLKEWKHPTLNRPYVELHKNNVRIVGYETVELKLGNKMYTIHFASISNLRKPFRKQKKKSIEYLKHLLTLALKRNLETYPSIIKRGKNFFLQYPVRVTVKVPKLTKNFKAFGIDRGVNRLAVGCIISKDGKLTNKNIFFFHGKEAWAKENRYKKIRDRLYAMAKKLRGDKTKKIRLYHEIRKKFRHKVKYFRRNYLHNISKQIVEIAKENTPTVIVLEDLRYLRERTYRGKGRSKKAKKTNYKLNTFTYRMLIDMIKYKAEEAGVPVMIIDPRNTSRKCSKCGYVDENNRKQASFKCLKCGYSLNADLNAAVNIAKAFYECPTFRWEEKLHAYVCSEPDK
			AuCas12f2	2236	MKSFKLKLLPTDEQNVLLNEVFCKWASLCTRMASKGHDKERLAPPDSSGNYFNKTQLNQVNTDVTDHMGALEESASQKERAVEKVKRRLKLISDMLSEPNLRDVSQQKPTTFRPLEWVKEGLLKTKYHTVHYWQKECDKLTKQKERMEKTIEKIKKGKITFKPTKMSLHQNCFSLSFGKGTFSMRPFSDTKRGINLDMLTAPIQPAIGKNDGKSSLRSKEFIARNIENYIIFSIHSQLFGLSRSEELLLNAKKEELVAKRDAMLKKKSDSLSKKIKELEKIVGRKITDSERSEIMSQGGKLSSEKFSEDNSYLKTLKVLAKDIIGREELFRLKKYPIVIRKPLNERKKLKNLKPDEWEYYLQLSYDELEKKEFTPKTIMGIDRGLKHILAIAIYDPVQNKFVKNMLIPNPILGWKWKLRKIKRSIQHMERRIRAQQNAHVPENQLKKRLKSIENKIDYYYHNVSRQILNLAHDFKSAIVVEDLQNMKQHGRKKSKGLRGLNYALSNFDYGKIMGLVKYKAESENVPLLTVLPAGTSQNCAYCLLYGKEQGNYVRNNVNSKIGKCKLHGEIDADINAARTIAICYHKNINEPKPYGERKTFKRK
PtCas12f1	2237	MKYTKVMRYQIIKPLNAEWDELGMVLRDIQKETRAALNKTIQLCWEYQGFSADYKQIHGQYPKPKDVLGYTSMHGYAYDRLKNEFSKIASSNLSQTIKRAVDKWNSDLKEILRGDRSIPNFRKDCPIDIVKQSTKIQKCNDGYVLSLGLINREYKNELGRKNGVFDVLIKANDKTQQTILERIINGDYTYTASQIINHKNKWFINLTYQFETKETALDPNNVMGVDLGIVYPVYIAFNNSLHRYHIKGGEIERFRRQVEKRKRELLNQGKYCGDGRKGHGYATRTKSIESISDKIARFRDTCNHKYSRFIVDMALKHNCGIIQMEDLTGISKESTFLKNWTYYDLQQKIEYKAREAGIQVIKIEPQYTSQRCSKCGYIDKENRQEQATFKCIECGFKTNADYNAARNIAIPNIDKIIRKTLKMQ
			RuCas12f1	2238	MTLLVKVVKIHLISEQFDKAGNRIDYEEVNKILWELQKQTREAKNKTVQLLWEWNNFSSDYVKASGIYPKAKDIFGYSSVHGQANKELRTKLALNSSNLSTTTMDVCKNFNTYKKEVWKGKRSVPSYKSDQPLDLHKDSIKLIYENNEFYVRLALLKKAEFAKYGFKDGFRFKMQVKDNSTKTILERCFDEVYKINASKLLYDQKKKKWKLNLSYSFDNKNISELDKEKILGVDVGVNCPLVASVFGDRDRFIIKGGEIEKFRKSVEARRRSMLEQTKYCGDGRIGHGRKKRTEPALNIGDKIARFRDTTNHKYSRALIEYAVKKGCGTIQMEKLTGITSKSDRFLKDWTYYDLQTKIENKAKEVGINVVYIAPKYTSQRCSKCGYIHKDNRPNQAKFRCLECDFESNADYNASQNIGIKNIDKIIEKDLQKQESEVQVNENK
SpCas12f1	2239	MGESVKAIKLKILDMFLDPECTKQDDNWRKDLSTMSRFCAEAGNMCLRDLYNYFSMPKEDRISSKDLYNAMYHKTKLLHPELPGKVANQIVNHAKDVWKRNAKLIYRNQISMPTYKITTAPIRLQNNIYKLIKNKNKYIIDVQLYSKEYSKDSGKGTHRYFLVAVRDSSTRMIFDRIMSKDHIDSSKSYTQGQLQIKKDHQGKWYCIIPYTFPTHETVLDPDKVMGVDLGVAKAVYWAFNSSYKRGCIDGGEIEHFRKMIRARRVSIQNQIKHSGDARKGHGRKRALKPIETLSEKEKNFRDTINHRYANRIVEAAIKQGCGTIQIENLEGIADTTGSKFLKNWPYYDLQTKIVNKAKEHGITVVAINPQYTSQRCSMCGYIEKTNRSSQAVFECKQCGYGSRTICINCRHVQVSGDVCEECGGIVKKENVNADYNAAKNISTPYIDQIIMEKCLELGIPYRSITCKECGHIQASGNTCEVCGSTNILKPKKIRKAK
			CnCas12f1	2240	MITVRKIKLTIMGDKDTRNSQYKWIRDEQYNQYRALNMGMTYLAVNDILYMNESGLEIRTIKDLKDCEKDIDKNKKEIEKLTARLEKEQNKKNSSSEKLDEIKYKISLVENKIEDYKLKIVELNKILEETQKERMDIQKEFKEKYVDDLYQVLDKIPFKHLDNKSLVTQRIKADIKSDKSNGLLKGERSIRNYKRNFPLMTRGRDLKFKYDDNDDIEIKWMEGIKFKVILGNRIKNSLELRHTLHKVIEGKYKICDSSLQFDKNNNLILNLTLDIPIDIVNKKVSGRVVGVDLGLKIPAYCALNDVEYIKKSIGRIDDFLKVRTQMQSRRRRLQIAIQSAKGGKGRVNKLQALERFAEKEKNFAKTYNHFLSSNIVKFAVSNQAEQINMELLSLKETQNKSILRNWSYYQLQTMIEYKAQREGIKVKYIDPYHTSQTCSKCGNYEEGQRESQADFICKKCGYKVNADYNAARNIAMSNKYITKKEESKYYKIKESMV
cA1	2241	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDGGFYKKLEKKHSEMFSFDRLNLLLNQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA3	2242	MEVQKTVMKTLSLRILRPLYSQEIEKEIKEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
cA4	2243	MAKNTITKTLKLRIVRPLYSQEIEKEIKEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA5	2244	MIKVYRYEIVKPLDLDWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
cA6	2245	MITVRKIKLTIMGDKDTRNSQYKWIRDEQYNQYRALNMGMTYLAVNDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA7	2246	MGESVKAIKLKILDMFLDPECTKQDDNWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
Cas variant/cA 8	2247	MKYTKVMRYQIIKPLNAEWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA9	2248	MTLLVKVVKIHLISEQFDKAGNRIDYEEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA1	2249	MAKNTITKTLKLRIVRPYYSQEIEKIVAEEKNRREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA2	2250	MAKNTITKTLKLRIVRPYYSAEVEKIVAEEKNNREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRGQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA3	2251	MAKNTITKTLKLRIVRPYYSAEIEKIVADEKNRREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRKQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA4	2252	MAKNTITKTLKLRIVRPYNSQEVEKIVAEEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA5	2253	MAKNTITKTLKLRIVRPYNSQEVEKIVAEEKNNREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA6	2254	MAKNTITKTLKLRIVRPYNSQEVEKIVAEEKNNREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRGQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA7	2255	MAKNTITKTLKLRIVRPYYSAEVEKIVAEEKNNREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA8	2256	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA9	2257	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRGQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA10	2258	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA11	2259	MAKNTITKTLKLRIVRPYNSAEIEKIVAEEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA12	2260	MAKNTITKTLKLRIVRPYNSAEVEKIVAEEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA13	2261	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA14	2262	MAKNTITKTLKLRIVRPYYSAEIEKIVADEKNRREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mA15	2263	MAKNTITKTLKLRIVRPYYSAEIEKIVAEEKNRREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mA16	2264	MAKNTITKTLKLRIVRPYYSAEIEKIVAEEKNNREKIALDKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAREIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mB1	2265	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAARLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFKISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mB2	2266	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFKISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mB3	2267	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAGLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFKISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mB4	2268	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAARLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFRISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mB5	2269	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFRISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mB6	2270	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAGLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFRISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mB7	2271	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAARLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFSISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mB8	2272	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFSISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mB9	2273	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAGLFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFSISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFRQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIRKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC1	2274	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLENFNKKMFARRRILLKKNRHKRGGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC2	2275	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIEGGDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC3	2276	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIEGGDLENFNKKMFARRRILLKKNRHKRGGHGRDKKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC4	2277	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIEGGDLENFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC5	2278	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGRDKKLKPIEQLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC6	2279	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLENFNKKMFARRRILLKKNRHKRAGHGRDKKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC7	2280	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLEHFNKKMFARRRILLKKNRHKRKGHGAKNKLKPIETLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC8	2281	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIDGGDLEHFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC9	2282	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIDGGDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPIETLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC10	2283	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIDGGDLEHFNKKMFARRRILLKKNRHKRKGHGAKNKLKPIETLTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC11	2284	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSIDSNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC12	2285	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSIDSNDLFHFNKKMFARRRILLKKNRHKRAGHGAAHKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC13	2286	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSIDSNDLFKFNKKMFARRRILLKKNRHKRAGHGAAHKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC14	2287	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIDSNDLFKFNKKMFARRRILLKKNRHKRAGHGAAHKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC15	2288	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSIDSNDLFKFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC16	2289	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC17	2290	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIDSNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC18	2291	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAAHKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC19	2292	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIKGGDLERFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC20	2293	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIKGGDLERFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC21	2294	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIKGGDLEKFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC22	2295	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIKGGDLFHFNKKMFARRRILLKKNRHKRAGHGRKKKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mC23	2296	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLEKFNKKMFARRRILLKKNRHKRAGHGRKKKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mC24	2297	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSIKGGDLEKFNKKMFARRRILLKKNRHKRAGHGRKKKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mD1	2298	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWAKEIADFFIKNKVGTVQMEDLSTMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAARNISTPDIKSTKERP
mD2	2299	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			mD3	2300	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWAKEIADFFIKNKVGTVQMEDLSTMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mD4	2301	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			mD5	2302	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISTPDIKSTKERP
mD6	2303	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLSTMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mD7	2304	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
mD8	2305	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAARNISTPDIKSTKERP
			mD9	2306	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWSRYIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIKIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKANAAYNAARNISNPNIKSTKERP
mD10	2307	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACYIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
			mD11	2308	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACYIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAARNISNPKLKSTKERP
mD12	2309	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACYIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
			mD13	2310	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWARYIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIKIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
mD14	2311	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAARNISNPNIKSTKERP
			mD15	2312	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
mD16	2313	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAARNISNPNIKSTKERP
			mD17	2314	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWANRIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIKIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAAKNISNPKLKSTKERP
mD18	2315	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAAKNISNPKLKSTKERP
			mD19	2316	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIKIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAAKNISNPKLKSTKERP
mD20	2317	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWANRIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIKIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			mD21	2318	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWANRIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKRNAAYNAALNISNPKLKSTKERP
mD22	2319	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWSRFIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYYEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
			cB2	2320	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIDVQLYSKEYSKDSGKGTHRYFLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
cB3	2321	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIASLSLLSNPAKQEMNVKRKISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cD1	2322	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPIYERKPNRSIVGGLAVGIRSPLVCAINNSFSRYSVDSNDVFKFSKQVFAFRRRLLSKNSLKRKGHGAAHKLEPITEMTEKNDKFRKKIIERWAKEVTNFFVKNQVGIVQIEDLSTMKDREDHFFNQYLRGFWPYYQMQTLIENKLKEYGIEVKRVQAKYTSQLCSNPNCRYWNNYFNFEYRKVNKFPKFKCEKCNLEISAAYNAARNLSTPDIEKFVAKATKGINLPEK
cD2	2323	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPTHETVLDPDKVMGVALGVAKAVYWAFNSSYKRGCIDGGEIEHFRKMIRARRVSIQNQIKHSGDARKGHGRKRALKPIETLSEKEKNFRDTINHRYANRIVEAAIKQGCGTIQIENLEGIADTTGSKFLKNWPYYDLQTKIVNKAKEHGITVVAINPQYTSQRCSMCGYIEKTNRSSQAVFECKQCGYGSRTICINCRHVQVSGDVCEECGGIVKKENVNAAYNAAKNISTPYIDQIIMEKCLELGIPYRSITCKECGHIQASGNTCEVCGSTNILKPKK
			cD3	2324	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPQTRVLDLNKIMGIALGVAVAVYMAFQHTPARYKLEGGEIENFRRQVESRRISMLRQGKYAGGARGGHGRDKRIKPIEQLRDKIANFRDTTNHRYSRYIVDMAIKEGCGTIQMEDLTNIRDIGSRFLQNWTYYDLQQKIIYKAEEAGIKVIKIDPQYTSQRCSECGNIDSGNRIGQAIFKCRACGYEANAAYNAARNIAIPNIDKIIAESIK
cD4	2325	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPIDIVNKKVSGRVVGVALGLKIPAYCALNDVEYIKKSIGRIDDFLKVRTQMQSRRRRLQIAIQSAKGGKGRVNKLQALERFAEKEKNFAKTYNHFLSSNIVKFAVSNQAEQINMELLSLKETQNKSILRNWSYYQLQTMIEYKAQREGIKVKYIDPYHTSQTCSKCGNYEEGQRESQADFICKKCGYKVNAAYNAARNIAMSNKYITKKEESKYYKIKESMV
			cD5	2326	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVETKETALDPNNVMGVALGIVYPVYIAFNNSLHRYHIKGGEIERFRRQVEKRKRELLNQGKYCGDGRKGHGYATRTKSIESISDKIARFRDTCNHKYSRFIVDMALKHNCGIIQMEDLTGISKESTFLKNWTYYDLQQKIEYKAREAGIQVIKIEPQYTSQRCSKCGYIDKENRQEQATFKCIECGFKTNAAYNAARNIAIPNIDKIIRKTLKMQ
cD6	2327	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVNRSIVGGLAVGIRSPLVCAINNSFSRYSVDSNDVFKFSKQVFAFRRRLLSKNSLKRKGHGAAHKLEPITEMTEKNDKFRKKIIERWAKEVTNFFVKNQVGIVQIEDLSTMKDREDHFFNQYLRGFWPYYQMQTLIENKLKEYGIEVKRVQAKYTSQLCSNPNCRYWNNYFNFEYRKVNKFPKFKCEKCNLEISAAYNAARNLSTPDIEKFVAKATKGINLPEK
			cD7	2328	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPDKVMGVALGVAKAVYWAFNSSYKRGCIDGGEIEHFRKMIRARRVSIQNQIKHSGDARKGHGRKRALKPIETLSEKEKNFRDTINHRYANRIVEAAIKQGCGTIQIENLEGIADTTGSKFLKNWPYYDLQTKIVNKAKEHGITVVAINPQYTSQRCSMCGYIEKTNRSSQAVFECKQCGYGSRTICINCRHVQVSGDVCEECGGIVKKENVNAAYNAAKNISTPYIDQIIMEKCLELGIPYRSITCKECGHIQASGNTCEVCGSTNILKPKK
cD8	2329	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDLNKIMGIALGVAVAVYMAFQHTPARYKLEGGEIENFRRQVESRRISMLRQGKYAGGARGGHGRDKRIKPIEQLRDKIANFRDTTNHRYSRYIVDMAIKEGCGTIQMEDLTNIRDIGSRFLQNWTYYDLQQKIIYKAEEAGIKVIKIDPQYTSQRCSECGNIDSGNRIGQAIFKCRACGYEANAAYNAARNIAIPNIDKIIAESIK
			cD9	2330	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPNNVMGVALGIVYPVYIAFNNSLHRYHIKGGEIERFRRQVEKRKRELLNQGKYCGDGRKGHGYATRTKSIESISDKIARFRDTCNHKYSRFIVDMALKHNCGIIQMEDLTGISKESTFLKNWTYYDLQQKIEYKAREAGIQVIKIEPQYTSQRCSKCGYIDKENRQEQATFKCIECGFKTNAAYNAARNIAIPNIDKIIRKTLKMQ
cD10	2331	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDKEKILGVAVGVNCPLVASVFGDRDRFIIKGGEIEKFRKSVEARRRSMLEQTKYCGDGRIGHGRKKRTEPALNIGDKIARFRDTTNHKYSRALIEYAVKKGCGTIQMEKLTGITSKSDRFLKDWTYYDLQTKIENKAKEVGINVVYIAPKYTSQRCSKCGYIHKDNRPNQAKFRCLECDFESNAAYNASQNIGIKNIDKIIEKDLQKQESEVQVNENK
			t1	2332	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.1	2333	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.2	2334	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.3	2335	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.4	2336	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.5	2337	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.6	2338	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.7	2339	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.8	2340	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.9	2341	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.10	2342	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.11	2343	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.12	2344	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.13	2345	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.14	2346	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.15	2347	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.16	2348	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.17	2349	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.18	2350	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.19	2351	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.20	2352	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.21	2353	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.22	2354	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.23	2355	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.24	2356	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.25	2357	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.26	2358	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.27	2359	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.28	2360	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.29	2361	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.30	2362	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.31	2363	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.32	2364	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.33	2365	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.34	2366	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.35	2367	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.36	2368	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.37	2369	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.38	2370	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.39	2371	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.40	2372	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.41	2373	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.42	2374	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.43	2375	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.44	2376	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.45	2377	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.46	2378	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.47	2379	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.48	2380	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.49	2381	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.50	2382	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.51	2383	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.52	2384	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.53	2385	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.54	2386	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.55	2387	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.56	2388	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.57	2389	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.58	2390	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.59	2391	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.60	2392	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.61	2393	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.62	2394	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.63	2395	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.64	2396	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.65	2397	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.66	2398	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.67	2399	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.68	2400	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.69	2401	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.70	2402	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.71	2403	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.72	2404	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.73	2405	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISTPDIKSTKERP
			cA2.74	2406	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNISNPNIKSTKERP
cA2.75	2407	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.76	2408	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.77	2409	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
			cA2.78	2410	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNI
cA2.79	2411	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQRCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAARNI
			cA2.80	2412	MAKNTITKTLKLRIVRPYNSQEIEKIVAEEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNI
cA2.81	2413	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNSFSRYSISDNDLFKFNKKMFARRRILLKKNRHKRKGHGAKNKLKPITELTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.82	2414	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.83	2415	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKERRKQAGGTGELDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.84	2416	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKERRKQAGGTGELDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAALFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.85	2417	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKERRKQAGGTGELDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.86	2418	MAKNTITKTLKLRIVRPYNSAEIEKIVADEKERRKQAGGTGELDDKFYKKLRKQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPKFKCEKCNFKENAAYNAALNISNPDIKSTKERP
cA2.87	2419	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMEDLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
			cA2.88	2420	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPKLKSTKERP
cA2.89	2421	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP
			cA2.90	2422	MAKNTITKTLKLRIVRPYNSAEVEKIVADEKERRKQAGGTGELDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSRVCYRRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVRSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSQLCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENAAYNAALNISNPDIKSTKERP

Polynucleotides, vectors, and cells

Also provided herein are polynucleotides comprising a nucleotide sequence encoding any one of the engineered gene effector or fusion proteins of the present disclosure. In some embodiments, the polynucleotide comprises a nucleotide sequence encoding an engineered gene effector as described herein. In some embodiments, the polynucleotide comprises a nucleotide sequence encoding a fusion protein described herein.

Also provided are vectors (e.g., expression vectors) comprising polynucleotides of the disclosure, e.g., comprising a nucleotide sequence encoding an engineered gene effector as described herein. In some embodiments, the vector comprises a polynucleotide comprising a nucleotide sequence encoding any one of the engineered gene effectors described herein. In some embodiments, the vector comprises a polynucleotide comprising a nucleotide sequence encoding any one of the fusion proteins described herein. In some embodiments, the vector is a viral vector.

In some embodiments, the methods of delivering a polynucleotide provided herein to a cell can involve viral or non-viral delivery methods. Thus, the polynucleotide may be one or more viral vectors (e.g., one or more AAV vectors). Or the polynucleotide may be a non-viral vector such as a cationic lipid and/or lipid particle (e.g., a Lipid Nanoparticle (LNP)) complexed with or encapsulated by a non-viral delivery moiety.

Non-viral delivery methods of nucleic acids may include lipofection, nuclear transfection, microinjection, gene guns, virosomes, liposomes, immunoliposomes, polycations or lipids: nucleic acid conjugates, naked DNA, artificial viral particles and agent-enhanced DNA uptake. Cationic lipids and neutral lipids suitable for lipid transfection can be identified using high efficiency receptors for polynucleotides. May be delivered to cells (e.g., administered in vitro or ex vivo) or target tissue (e.g., administered in vivo).

In some embodiments, the compositions and systems provided herein are delivered to a subject using a viral vector. In some cases, the viral vector is an adeno-associated virus (AAV) vector. The term "AAV" is an abbreviation for adeno-associated virus and may be used to refer to the virus itself or derivatives thereof. Unless otherwise required, the term encompasses all serotypes, subtypes, and naturally occurring and recombinant forms. The abbreviation "rAAV" refers to recombinant adeno-associated virus, also known as recombinant AAV vector (or "rAAV vector"). The term "AAV" includes AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, rh10 and hybrids thereof, avian AAV, bovine AAV, canine AAV, equine AAV, primate AAV, non-primate AAV, and ovine AAV. The genomic sequences of AAV of different serotypes and the sequences of the natural Terminal Repeat (TR), rep proteins, and capsid subunits are known in the art. These sequences can be found in the literature or in public databases such as GenBank. As used herein, "rAAV vector" refers to an AAV vector comprising a polynucleotide sequence that is not AAV-derived (i.e., a polynucleotide heterologous to AAV), typically a sequence of interest for cellular gene transformation. Typically, the heterologous polynucleotide is flanked by at least one, and typically two, AAV Inverted Terminal Repeats (ITRs). The term rAAV vector encompasses both rAAV vector particles and rAAV vector plasmids. The rAAV vector may be single stranded (ssAAV) or self-complementary (scAAV). "AAV virus" or "AAV viral particle" or "rAAV vector particle" refers to a viral particle comprised of at least one AAV capsid protein and a packaged polynucleotide rAAV vector. If the particle comprises a heterologous polynucleotide (i.e., a polynucleotide other than the wild-type AAV genome, such as a transgene to be delivered to a mammalian cell), it is generally referred to as a "rAAV vector particle" or simply "rAAV vector". Thus, production of a rAAV particle must include production of a rAAV vector because such a vector is contained in the rAAV particle. In some cases, AAV vectors are selected based on the tropism of the viral vectors. In some embodiments, AAV vectors having tropism for a target tissue may be used to deliver polynucleotides encoding the compositions and systems provided herein to the target tissue.

RNA or DNA virus-based systems can be used to target specific cells in the body and deliver viral payloads to the nucleus. Viral vectors may be administered directly (in vivo), or they may be used to treat cells in vitro, and modified cells may optionally be administered (ex vivo). Viral-based systems may include retroviral, lentiviral, adenoviral, adeno-associated viral and herpes simplex viral vectors for gene transfer. Integration in the host genome can occur using retroviral, lentiviral, and adeno-associated viral gene transfer methods, which can lead to long-term expression of the inserted transgene. High transduction efficiencies can be observed in many different cell types and target tissues.

The potential targeting population of target cells can be expanded by altering the tropism of retroviruses by incorporating exogenous envelope proteins. Lentiviral vectors are retroviral vectors that transduce or infect non-dividing cells and produce high viral titers. The choice of retroviral gene transfer system may depend on the target tissue. Retroviral vectors may contain cis-acting long terminal repeats with packaging capability for foreign sequences up to 6-10kb in length. The minimal cis-acting LTR may be sufficient to replicate and package a vector that can be used to integrate the therapeutic gene into the target cell to provide permanent transgene expression. Retroviral vectors may include vectors based on murine leukemia virus (MuLV), gibbon simian leukemia virus (GaLV), simian Immunodeficiency Virus (SIV) or Human Immunodeficiency Virus (HIV), and combinations thereof.

Adenovirus-based systems may be used. Adenovirus-based systems can cause transient expression of transgenes. Adenovirus-based vectors can have high transduction efficiency in cells, and cell division may not be required. High titres and high levels of expression can be obtained with adenovirus-based vectors. Adeno-associated virus ("AAV") vectors are useful for transducing cells with target nucleic acids (e.g., in the in vitro production of nucleic acids and peptides), as well as for in vivo and ex vivo gene therapy procedures.

Also provided are cells comprising the polynucleotides of the disclosure or vectors of the disclosure. In some embodiments, the cell comprises a polynucleotide comprising a nucleotide sequence encoding an engineered gene effector or fusion protein of the present disclosure. In some embodiments, the cell comprises a vector comprising a nucleotide sequence encoding an engineered gene effector of the present disclosure. In some embodiments, the cell comprises a vector comprising a polynucleotide comprising a nucleotide sequence encoding a fusion protein of the present disclosure.

Packaging cells can be used to form viral particles capable of infecting host cells. Such cells may include 293 cells (e.g., for packaging adenovirus), and Psi2 cells or PA317 cells (e.g., for packaging retrovirus). Viral vectors can be generated by generating cell lines that package the nucleic acid vector into viral particles. The vector may contain minimal viral sequences required for packaging and subsequent integration into a host. The vector may comprise other viral sequences substituted with an expression cassette for the polynucleotide to be expressed. The deleted viral function may be provided in trans by the packaging cell line. For example, an AAV vector may comprise ITR sequences from the AAV genome that are necessary for packaging and integration into the host genome. Viral DNA may be packaged in a cell line that may contain helper plasmids encoding other AAV genes (i.e., rep and cap) while lacking ITR sequences. The cell line may also be infected with adenovirus as a helper. Helper viruses can promote replication of AAV vectors and expression of AAV genes from helper plasmids. Adenovirus contamination can be reduced by, for example, heat treatment (adenovirus is more sensitive to heat treatment than AAV).

Host cells may be transiently or non-transiently transfected with one or more of the vectors described herein. The cell may be transfected as it naturally occurs in the subject. Cells may be removed from or derived from a subject and transfected. The cells may be derived from cells (e.g., cell lines) taken from the subject. In some embodiments, cells transfected with one or more vectors described herein are used to establish new cell lines comprising one or more vector-derived sequences. In some embodiments, cells transiently transfected with the compositions of the present disclosure (e.g., transiently transfected with one or more vectors, or transfected with RNA) and modified by the activity of a heterologous polypeptide comprising the engineered gene effectors and heterologous endonucleases disclosed herein are used to establish a new cell line comprising cells containing the modifications but lacking any other exogenous sequences.

Any suitable vector that is compatible with the host cell may be used in the methods of the present disclosure. Non-limiting examples of vectors for eukaryotic host cells include pXT1, pSG5 (Stratagene ^TM), pSVK3, pBPV, pMSG and pSVLSV40 (Pharmacia ^TM).

In some embodiments, the polynucleotide may further comprise one or more promoters (or one or more transcriptional control elements as used interchangeably herein). The different active ingredients encoded by the polynucleotides may be under the control of the same promoter or under the control of different promoters. Promoters disclosed and used herein may be active in eukaryotic cells, mammalian cells, non-human mammalian cells, or human cells. The promoter may be an inducible or a constitutively active promoter. Alternatively or additionally, the promoter may be tissue or cell specific. Non-limiting examples of suitable eukaryotic promoters (i.e., promoters that function in eukaryotic cells) may include the Cytomegalovirus (CMV) immediate early promoter, the Herpes Simplex Virus (HSV) thymidine kinase promoter, the SV40 early and late promoters, the retroviral Long Terminal Repeat (LTR) promoter, the human elongation factor-1 promoter (EF 1), hybrid constructs comprising a Cytomegalovirus (CMV) enhancer fused to a chicken beta-active promoter (CAG), the murine stem cell virus promoter (MSCV), the phosphoglycerate kinase-1 locus Promoter (PGK), or the mouse metallothionein-I promoter. The promoter may be a fungal promoter. The promoter may be a plant promoter. A plant promoter database (e.g., plantProm) can be found. The vector may also contain a ribosome binding site for translation initiation and a transcription terminator. The vector may also contain suitable sequences for amplified expression. In some cases, the promoters disclosed herein may be any of the tissue-specific promoters provided herein, or any of the cell type-specific promoters provided herein.

The polynucleotides (e.g., a single heterologous polynucleotide) in a polynucleotide combination can have a size of at least or up to about 2.5 kilobases, at least or up to about 2.6 kilobases, at least or up to about 2.7 kilobases, at least or up to about 2.8 kilobases, at least or up to about 2.9 kilobases, at least or up to about 3.0 kilobases, at least or up to about 3.1 kilobases, at least or up to about 3.2 kilobases, at least or up to about 3.3 kilobases, at least or up to about 3.4 kilobases, at least or up to about 3.5 kilobases, at least or up to about 3.6 kilobases, at least or up to about 3.7 kilobases, at least or up to about 3.8 kilobases, at least or up to about 3.9 kilobases, at least or up to about 4.0 kilobases, at least or up to about 4.1 kilobases, at least or up to about 4.2 kilobases, at least or up to about 4.3 kilobases, at least or up to about 4.4 kilobases, at least or up to about 4.5 kilobases, at least or up to about 4.6 kilobases, at least or up to about 7.7 kilobases, at least or up to about 4.0, at least or up to about 5 kilobases, at least or up to about 4.0.7 kilobases, at least or up to about 5 kilobases, at least or up to about 4.5 kilobases, or up to about 5 kilobases, at least about 0.5 kilobases, or up to about 5 kilobases. In some cases, a heterologous polynucleotide (e.g., a single heterologous polynucleotide) of one or more heterologous polynucleotides can have a size of between about 3 kilobases and about 5 kilobases, between about 3 kilobases and about 4.8 kilobases, between about 3 kilobases and about 4.6 kilobases, between about 3 kilobases and about 4.4 kilobases, between about 3 kilobases and about 4.2 kilobases, between about 3 kilobases and about 4.0 kilobases, between about 3 kilobases and about 3.5 kilobases, between about 3.5 kilobases and about 5 kilobases, between about 3.5 kilobases and about 4.8 kilobases, between about 3.5 kilobases and about 4.6 kilobases, between about 3.5 kilobases and about 4.4 kilobases, between about 3.5 kilobases and about 4.2 kilobases, between about 3.5 kilobases and about 4 kilobases, between about 4 kilobases and about 4.2 kilobases, between about 3.5 kilobases and about 4.5 kilobases, between about 4.5 kilobases and about 4.8 kilobases, between about 4.5 kilobases and about 4.5 kilobases, between about 4.5 kilobases and about 4.8 kilobases.

System and method for controlling a system

In some aspects, disclosed herein are systems comprising an engineered gene effector, a guide nucleic acid, a heterologous endonuclease (e.g., an endonuclease that lacks or substantially lacks cleavage activity). The systems of the present disclosure can be used, for example, to bring one or more heterologous gene effectors into close proximity with a target gene (e.g., a target endogenous gene) or target gene regulatory sequence, thereby facilitating regulation of the level of expression or activity of the target gene.

In some embodiments, the systems of the present disclosure bind to DNA (e.g., genomic DNA). In some embodiments, the systems of the present disclosure bind to RNA (e.g., mRNA, microRNA, siRNA or non-coding RNA). In some embodiments, the systems of the present disclosure bind to DNA and RNA.

In some embodiments, the system can modulate (e.g., increase) expression and/or activity of a target gene (e.g., a target endogenous gene) by physically blocking a polynucleotide sequence (e.g., a promoter, enhancer, repressor, operator or silencer, insulator, cis-regulatory element, trans-regulatory element, epigenetic modification (e.g., DNA methylation) site or coding sequence).

In some embodiments, the system can modulate (e.g., increase) expression and/or activity of a target gene (e.g., a target endogenous gene) by recruiting additional factors that are effective to repress or enhance expression of the target gene.

In some embodiments, the systems of the present disclosure are used to introduce epigenetic modifications to a target gene (e.g., a target endogenous gene) or a target gene regulatory sequence (e.g., a promoter, enhancer, silencer, insulator, cis regulatory element, trans regulatory element, or epigenetic modification (e.g., DNA methylation) site). In some embodiments, the systems of the present disclosure are used to generate three-dimensional structures, topologically related domains, or genomic boundaries comprising a target gene or target gene regulatory sequence (e.g., a gene from the distal or proximal end of a target gene).

In some embodiments, modulation of a target gene (e.g., a target endogenous gene) by a system disclosed herein (e.g., a system comprising one or more heterologous gene effectors, heterologous endonucleases, and guide nucleic acids) can utilize endogenous target gene regulatory sequences operably coupled to the target gene, e.g., promoters, enhancers, repressors, silencers, insulators, cis-regulatory elements, trans-regulatory elements, epigenetic modification (e.g., DNA methylation) sites, and the like. Thus, such modulation of a target gene by a system may not involve and need not involve exogenous, synthetic, and/or heterologous regulatory sequences, such as promoters, enhancers, repressors, silencers, insulators, cis-regulatory elements, trans-regulatory elements, epigenetic modification (e.g., DNA methylation) sites, and the like, that are heterologous with respect to a subject or host cell. In some embodiments, the modulation of the target gene by the complex does not involve the use of engineered induction systems, repression systems, and/or reporting systems. In some embodiments, the modulation of a target gene by the system does not involve the use of exogenous, engineered, or synthetic regulatory elements, e.g., does not involve responsive elements that are modulated by tetracycline or an analog thereof. In some embodiments, the modulation of the target gene by the system does not involve the use of transactivators or reverse transactivators that function as part of the engineered induction system, repressor system, and/or reporter system. In some embodiments, the regulation of the target gene by the system does not involve a tetoff or tTA dependent system or components thereof. In some embodiments, the modulation of the target gene by the system does not involve a Tet On or rtTA dependent system or components thereof.

In some embodiments, the systems disclosed herein (e.g., complexes comprising one or more engineered gene effectors, heterologous endonucleases, and guide nucleic acids) may be capable of modulating a target gene (e.g., a target endogenous gene) without further control of the modulator (e.g., an agent that directly or indirectly allows the complex to increase or decrease expression of the target gene). In some embodiments, the system is capable of modulating a target gene without involving a transactivator, a reverse transactivator, a small molecule, a drug, a chemical inducer of dimerization or multimerization, an additional inducer, an additional repressor, or any combination thereof. For example, after a single system is introduced into a host cell (e.g., each individual component of a single complex is expressed and/or transfected into a host cell), such introduction may be sufficient to allow the single system to regulate the expression or activity of a target gene.

In some embodiments, the system comprises an engineered gene effector of the present disclosure, a heterologous endonuclease, and a guide nucleic acid. In some embodiments, the system comprises an engineered gene effector, a heterologous endonuclease, and a guide nucleic acid. In some embodiments, the system comprises two engineered gene effectors, a heterologous endonuclease, and a guide nucleic acid. In some embodiments, the system comprises more than three engineered gene effectors, a heterologous endonuclease, and a guide nucleic acid. In some embodiments, the system comprises an engineered gene effector, a heterologous endonuclease, and a guide. In some embodiments, the complex comprises two engineered gene effectors, a heterologous endonuclease, and a guide. In some embodiments, the complex comprises more than three engineered gene effectors, a heterologous endonuclease, and one guide.

In some embodiments, the system comprises an engineered gene effector, a heterologous endonuclease coupled to the engineered gene effector, and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene (e.g., a promoter or regulatory sequence of the target gene) in a cell when the system is expressed in the cell. In some embodiments, the system comprises an engineered gene effector, a heterologous endonuclease coupled to the engineered gene effector (wherein the heterologous endonuclease is a Cas protein), and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell. In some embodiments, the binding specificity is determined by using a guide nucleic acid, such as a single guide RNA (sgRNA) or a portion thereof. In some embodiments, the use of different sgrnas allows the compositions, combinations, systems, and methods of the present disclosure to be used with (e.g., targeted to) different target genes (e.g., target endogenous genes) or target gene regulatory sequences.

In some embodiments, the heterologous endonuclease (e.g., and thus by an engineered gene effector operably coupled to the heterologous endonuclease) forms a complex with a guide nucleic acid (e.g., a guide RNA or a portion thereof). In some embodiments, the heterologous endonuclease forms a complex with a unidirectional guide nucleic acid, such as unidirectional guide RNA (sgRNA). In some embodiments, the heterologous endonuclease is an RNA Binding Protein (RBP), which is optionally complexed with a guide nucleic acid (e.g., a guide RNA (e.g., sgRNA)) capable of forming a complex with a Cas protein. In some embodiments, the heterologous endonuclease is a nuclease deleted DNA binding protein that can induce transcriptional activation or repression of the target DNA sequence. In some embodiments, the heterologous endonuclease is an RNA-derived nuclease-deleted RNA-binding protein.

The guide nucleic acids used in the compositions, combinations, systems and methods of the present disclosure can be, for example, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, at least 23, at least 24, at least 25, at least 26, at least 27, at least 28, at least 29, at least 30, at least 31, at least 32, at least 33, at least 34, at least 35, at least 36, at least 37, at least 38, at least 39 or at least 40 nucleotides.

In some embodiments, the guide nucleic acids used in the compositions, combinations, systems, and methods of the present disclosure are up to 10, up to 11, up to 12, up to 13, up to 14, up to 15, up to 16, up to 17, up to 18, up to 19, up to 20, up to 21, up to 22, up to 23, up to 24, up to 25, up to 26, up to 27, up to 28, up to 29, up to 30, up to 31, up to 32, up to 33, up to 34, up to 35, up to 36, up to 37, up to 38, up to 39, or up to 40 nucleotides.

In some embodiments, the guide nucleic acids used in the compositions, combinations, systems, and methods of the present disclosure are from about 8 to about 40 nucleotides, from about 10 to about 40 nucleotides, from about 11 to about 40 nucleotides, from about 12 to about 40 nucleotides, from about 13 to about 40 nucleotides, from about 14 to about 40 nucleotides, from about 15 to about 40 nucleotides, from about 16 to about 40 nucleotides, from about 17 to about 40 nucleotides, from about 18 to about 40 nucleotides, from about 19 to about 40 nucleotides, from about 20 to about 40 nucleotides, from about 22 to about 40 nucleotides, About 24 to about 40 nucleotides, about 26 to about 40 nucleotides, about 28 to about 40 nucleotides, about 30 to about 40 nucleotides, about 8 to about 30 nucleotides, about 10 to about 30 nucleotides, about 11 to about 30 nucleotides, about 12 to about 30 nucleotides, about 13 to about 30 nucleotides, about 14 to about 30 nucleotides, about 15 to about 30 nucleotides, about 16 to about 30 nucleotides, about 17 to about 30 nucleotides, about 18 to about 30 nucleotides, about 19 to about 30 nucleotides, about 20 to about 30 nucleotides, about 22 to about 30 nucleotides, about 24 to about 30 nucleotides, about 26 to about 30 nucleotides, about 28 to about 30 nucleotides, about 8 to about 25 nucleotides, about 10 to about 25 nucleotides, about 11 to about 25 nucleotides, about 12 to about 25 nucleotides, about 13 to about 25 nucleotides, about 14 to about 25 nucleotides, about 15 to about 25 nucleotides, about 16 to about 25 nucleotides, about 17 to about 25 nucleotides, about 18 to about 25 nucleotides, about 19 to about 25 nucleotides, about 20 to about 25 nucleotides, About 22 to about 25 nucleotides, about 24 to about 25 nucleotides, about 8 to about 20 nucleotides, about 10 to about 20 nucleotides, about 11 to about 20 nucleotides, about 12 to about 20 nucleotides, about 13 to about 20 nucleotides, about 14 to about 20 nucleotides, about 15 to about 20 nucleotides, about 16 to about 20 nucleotides, about 17 to about 20 nucleotides, about 18 to about 20 nucleotides, about 19 to about 20 nucleotides, about 8 to about 18 nucleotides, about 10 to about 18 nucleotides, about 11 to about 18 nucleotides, About 12 to about 18 nucleotides, about 13 to about 18 nucleotides, about 14 to about 18 nucleotides, about 15 to about 18 nucleotides, about 16 to about 18 nucleotides, about 8 to about 16 nucleotides, about 10 to about 16 nucleotides, about 11 to about 16 nucleotides, about 12 to about 16 nucleotides, about 13 to about 16 nucleotides, about 14 to about 16 nucleotides, or about 15 to about 16 nucleotides. in some embodiments, the guide nucleic acid is a guide RNA or a portion thereof.

In some embodiments, the system comprises any of the engineered gene effectors of the present disclosure, a heterologous endonuclease coupled to a polypeptide of the engineered gene effector (wherein the heterologous endonuclease comprises the amino acid sequence of any of SEQ ID NOS: 2222-2422), and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell. In some embodiments, the system comprises any of the engineered gene effectors of the present disclosure, a heterologous endonuclease fused to a polypeptide of the engineered gene effector, and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell. In some embodiments, the system comprises any of the engineered gene effectors of the present disclosure, a heterologous endonuclease fused to a polypeptide of the engineered gene effector (wherein the heterologous endonuclease is a Cas protein described herein), and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell. In some embodiments, the engineered gene effector polypeptide is fused to the C-terminus of the heterologous endonuclease (directly or indirectly through a linker).

In some embodiments, the system comprises an active ingredient (e.g., an engineered gene effector, a heterologous endonuclease, a guide nucleic acid, etc.), and optionally additional ingredients (e.g., excipients). The system may be segmented, shaped and/or packaged as necessary and/or desired as a single or multiple dose unit, or as a single or multiple implant unit.

Also provided are polynucleotide combinations encoding any of the systems of the present disclosure, wherein the polynucleotide combinations are configured to express in a cell a heterologous endonuclease coupled to an engineered gene effector and a guide nucleic acid.

Kit for detecting a substance in a sample

Also provided are kits comprising any one or more of the engineered gene effectors, fusion proteins, combinations, systems, polynucleotides, vectors, and/or cells of the disclosure. In some embodiments, the kit comprises instructions directing the cells to be contacted with any of the compositions (e.g., in vitro, ex vivo, or in vivo). The information and instructions may be in the form of text, pictures, or both, etc. In some embodiments, the kit comprises one or more containers (e.g., vials, ampoules, tubes, flasks, or bottles) for containing one or more components of the kit.

In some aspects, the disclosure provides a kit comprising any of the compositions disclosed herein (e.g., a combination of systems or polynucleotides) and instructions for (i) contacting a cell with any of the compositions (e.g., in vitro, ex vivo, or in vivo), or (ii) administering a cell comprising any of the compositions disclosed herein to a subject. The subject may have or be suspected of having a disorder (e.g., a genetic disease).

Method for regulating gene expression

Also provided herein are methods of controlling a target gene in a cell, the method comprising contacting the cell with a combination of any of the polynucleotides described herein or any of the systems described herein. In some embodiments, a method of controlling a target gene in a cell comprises contacting a cell of interest (e.g., a cell in which it is desired to regulate expression of the target gene) with any of the systems of the present disclosure. In some embodiments, a method of controlling a target gene in a cell comprises contacting the cell with a combination of any of the polynucleotides of the present disclosure. In some embodiments, the target gene is endogenous to the cell.

The present disclosure provides compositions, methods, and systems for modulating the expression of one or more target genes. Any suitable gene may be the target gene. The target gene may be one or more heterologous target genes. The target gene may be one or more endogenous target genes, such as (i) a pathogenic allele, e.g., a mutant allele, and/or (ii) a non-pathogenic allele, e.g., a wild-type allele. For example, disclosed herein are systems comprising a guide nucleic acid and one or more heterologous polypeptides or fusion proteins comprising an engineered gene effector and a heterologous endonuclease that can modulate (e.g., increase) the activity level or expression level of a target gene (e.g., in a cell).

In some embodiments, the target gene or regulatory sequence thereof is endogenous to the cell, e.g., present in the genome of the cell, or endogenous to the subject, e.g., present in the genome of the subject. In some embodiments, the target gene or regulatory sequence thereof is not part of an engineered reporter system.

In some embodiments, the target gene is exogenous to the host subject, e.g., a pathogen target gene, or an exogenous gene expressed as a result of a therapeutic intervention (e.g., gene therapy and/or cell therapy). In some embodiments, the target gene is an exogenous reporter gene. In some embodiments, the target gene is an exogenous synthetic gene.

In some embodiments, the systems, compositions, combinations, and methods disclosed herein are used to modulate (e.g., increase) expression of a target gene (e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide into a cell or cell population). In some embodiments, the expression level is an RNA expression level, which is determined by, for example, RNAseq, qPCR, microarray, gene array, FISH, or the like. In some embodiments, the expression level is a protein expression level, as determined by, for example, western blot, ELISA, multiplex immunoassay, mass spectrometry, NMR, proteomics, flow cytometry, or mass spectrometry flow cytometry, or the like.

In some embodiments, the target gene (e.g., endogenous target gene) is a mutant of a pathogenic allele, such as a wild-type allele. The disease may be a genetic disease, such as a genetic disorder. Non-limiting examples of genetic disorders may include Duchenne Muscular Dystrophy (DMD), hemophilia, cystic fibrosis, huntington's disease, familial hypercholesterolemia (LDL receptor deficiency), hepatoblastoma, wilson's disease, congenital hepatoporphyrin, hereditary liver metabolic disorders, LESCH NYHAN syndrome, sickle cell anemia, thalassemia, xeroderma pigmentosum, fanconi anemia, retinal pigment degeneration, ataxia telangiectasia, bloom syndrome, retinoblastoma, or tay-saxophone. In some cases, the target gene is a gene encoding a protein. In some cases, the target gene is a gene regulatory sequence (e.g., promoter, enhancer, repressor, silencer, insulator, cis-regulatory element, trans-regulatory element, epigenetic modification (e.g., DNA methylation) site, etc.) that affects the expression of a gene encoding a protein of interest provided herein. For example, the target gene regulatory sequence may be physically located outside of the transcriptional unit or open reading frame encoding the target gene product.

In some embodiments, the target gene regulatory sequence does not comprise a nucleotide sequence that is exogenous to the subject or host cell. In some embodiments, the target gene regulatory sequence does not comprise an engineered or artificially generated or introduced nucleotide sequence.

In some embodiments, the target gene (e.g., a target endogenous gene) is a gene that is over-expressed or under-expressed in a disease or disorder. In some embodiments, the target gene is a gene that is over-expressed or under-expressed in a genetic disease.

In some embodiments, the target gene (e.g., a target endogenous gene) is a gene that is overexpressed or underexpressed in the cancer, e.g., acute leukemia, astrocytoma, biliary tract cancer (cholangiocarcinoma), bone cancer, breast cancer, brain stem glioma, bronchioloalveolar lung cancer, adrenal gland cancer, anal region cancer, bladder cancer, endocrine system cancer, esophageal cancer, head and neck cancer, kidney cancer, parathyroid cancer, penile cancer, pleural/peritoneal cancer, salivary gland cancer, small intestine cancer, thyroid cancer, ureter cancer, urinary tract cancer, cervical cancer, endometrial cancer, fallopian tube cancer, renal pelvis cancer, vaginal cancer, vulval cancer, cervical cancer, chronic leukemia, colon cancer, colorectal cancer, skin melanoma, ependymoma, epidermoid tumor, ewing's sarcoma, gastric cancer, glioblastoma multiforme, glioma hematological malignancy, hepatocellular (liver) carcinoma, hepatocellular carcinoma, hodgkin's disease, intraocular melanoma, kaposi's sarcoma, lung cancer, lymphoma, medulloblastoma, melanoma, meningioma, mesothelioma, multiple myeloma, muscle carcinoma, central Nervous System (CNS) neoplasm, neuronal carcinoma, small cell lung carcinoma, non-small cell lung carcinoma, osteosarcoma, ovarian carcinoma, pancreatic carcinoma, pediatric malignancy, pituitary adenoma, prostate carcinoma, rectal carcinoma, renal cell carcinoma, soft tissue sarcoma, schwannoma, skin carcinoma, spinal axis tumor, squamous cell carcinoma, gastric carcinoma, synovial sarcoma, testicular carcinoma, uterine carcinoma, or tumor, or metastasis thereof, including refractory types of any of the cancers described above, or combinations thereof.

Non-limiting examples of target genes or genes encoding proteins of interest for use in some embodiments herein are disclosed in table 6.

In some embodiments, the methods disclosed herein activate the expression level of a target gene in a cell as compared to a control. In some embodiments, the method of contacting a cell with an engineered gene effector (e.g., an engineered gene activator) disclosed herein activates (e.g., alone or together with a heterologous endonuclease, such as Cas or dCas protein, e.g., an inactivated variant of Un1Cas12f1 comprising the polypeptide sequence of SEQ ID NO: 2231) the expression level of a target gene in the cell as compared to a control. The control can be the expression level (e.g., basal expression level) of the target gene in the control cell without any external manipulation of the target gene (e.g., the absence of engineered gene effectors and/or heterologous endonucleases). The control may be the expression level of the target gene in a control cell that is treated with a separate heterologous endonuclease (e.g., dCas) without any gene effector operatively coupled to the gene effector. The control can be the expression level of the target gene in a control cell that is treated with a control gene effector (e.g., alone or with a heterologous endonuclease). Non-limiting examples of control gene effectors may include VP16, VP64, p65, rta, and VPR. In some embodiments, the target gene is a silenced gene, e.g., a target gene at a methylation site. In some embodiments, the target gene is a methylated gene.

In some embodiments, the methods disclosed herein increase, about or increase the expression level of a target gene by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 250%, 300%, 400% or 500%, or more, or optionally, an engineered gene effector (e.g., with a heterologous endonuclease) is capable of increasing the expression level of a target gene by a percentage (e.g., 10% -100%, 100% -200%, 200% -400%, 250% -500%, 10% -50%, 50% -100%, etc.) within a range defined by any two of the foregoing values. In some embodiments, the methods comprise contacting a cell with an engineered gene effector of the present disclosure (e.g., with a heterologous endonuclease) to increase, at least or increase, by about 10%, at least or about 20%, at least or about 30%, at least or about 40%, at least or about 50%, at least or about 60%, at least or about 70%, at least or about 80%, at least or about 90%, at least or about 100%, at least or about 200%, at least or about 250%, at least or about 300%, at least or about 400%, or at least or about 500%, or more, the expression level of the target gene by a percentage (e.g., 10% -100%, 100% -200%, 200% -400%, 250% -500%, 10% -50%, 50% -100%, etc.) within a range defined by any two of the foregoing values.

In some embodiments, the engineered gene effector is capable of increasing the expression level of the target gene by at least about 0.1-fold, at least about 0.2-fold, at least about 0.3-fold, at least about 0.4-fold, at least about 0.5-fold, at least about 0.6-fold, at least about 0.7-fold, at least about 0.8-fold, at least about 0.9-fold, at least about 1-fold, at least about 1.1-fold, at least about 1.2-fold, at least about 1.3-fold, at least about 1.4-fold, at least about 1.5-fold, at least about 1.6-fold, at least about 1.7-fold, at least about 1.8-fold, at least about 1.9-fold, at least about 2-fold, at least about 2.5-fold, at least about 3-fold, at least about 3.5-fold, at least about 4-fold, at least about 4.5-fold, at least about 6-fold, at least about 7-fold, at least about 8-fold, at least about 9-fold, at least about 10-fold, at least about 15-fold, at least about 20-fold, at least about 30-fold, or at least about 50-fold.

In some embodiments, the engineered gene effector is capable of increasing the expression level of the target gene by at least about 0.1-fold, at least about 0.2-fold, at least about 0.3-fold, at least about 0.4-fold, at least about 0.5-fold, at least about 0.6-fold, at least about 0.7-fold, at least about 0.8-fold, at least about 0.9-fold, at least about 1-fold, at least about 1.1-fold, at least about 1.2-fold, at least about 1.3-fold, at least about 1.4-fold, at least about 1.5-fold, at least about 1.6-fold, at least about 1.7-fold, at least about 1.8-fold, at least about 1.9-fold, at least about 2-fold, at least about 2.5-fold, at least about 3-fold, at least about 3.5-fold, at least about 4-fold, at least about 4.5-fold, at least about 5-fold, at least about 6-fold, at least about 7-fold, at least about 8-fold, at least about 9-fold, at least about 10-fold, at least about 15-fold, at least about 20-fold, at least about 30-fold, at least about 40-fold, or at least about 50-fold, wherein the engineered gene effector is capable of increasing the expression level of the target gene by a factor value (e.g., 0.1-1.1-fold, 1-3-fold, 2.5-5-fold, 5-10-fold, 10-50-fold, 0.1-3-fold, 1-10-fold, or 0.1-20-fold) within a range defined by any two of the foregoing values.

In some embodiments, the target gene expression level increased by the engineered gene effector disclosed herein can be substantially sustained (e.g., at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 99%, or about 100%) for at least or up to about 1 hour, at least or up to about 2 hours, at least or up to about 6 hours, at least or up to about 12 hours, at least or up to about 18 hours, at least or up to about 24 hours, at least or up to about 2 days, at least or up to about 3 days, at least or up to about 4 days, at least or up to about, At least or up to about 5 days, at least or up to about 6 days, at least or up to about 7 days, at least or up to about 8 days, at least or up to about 9 days, at least or up to about 10 days, at least or up to about 11 days, at least or up to about 12 days, at least or up to about 13 days, at least or up to about 14 days, at least or up to about 3 weeks, at least or up to about 4 weeks, at least or up to about 2 months, at least or up to about 4 months, or at least or up to about 6 months. In some embodiments, the engineered gene effector is capable of activating a target gene in a cell (e.g., when the engineered gene effector is expressed in a cell and is effective to target a site of the target gene, e.g., as provided herein, when coupled or fused to a heterologous endonuclease complexed with a guide nucleic acid), wherein the expression level of the target gene activated by the engineered gene effector is for a period of time that is, about or at least 9 days, 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, or more, or optionally, the expression level is for a period of time that is within a range defined by any two of the foregoing values (e.g., 9-18 days, 18 days, 9-14 days, 12-18 days, 14-16 days, etc.). In some embodiments, the engineered gene effector is capable of activating a target gene in a cell (e.g., when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, e.g., when coupled or fused to a heterologous endonuclease complexed with a guide nucleic acid, as provided herein), wherein the level of expression of the target gene activated by the engineered gene effector lasts for a period of 9-14 days. In some embodiments, the engineered gene effector is capable of activating a target gene in a cell (e.g., when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, e.g., when coupled or fused to a heterologous endonuclease complexed with a guide nucleic acid, as provided herein), wherein the level of expression of the target gene activated by the engineered gene effector lasts for a period of 9-18 days. In some embodiments, the engineered gene effector is capable of activating a target gene in a cell (e.g., when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, e.g., when coupled or fused to a heterologous endonuclease complexed with a guide nucleic acid, as provided herein), wherein the level of expression of the target gene activated by the engineered gene effector lasts for about 14 days. In some embodiments, sustained activation comprises sustaining or maintaining at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 99% or about 100% of the peak or regulated level, or optionally, the percentage of sustained activation comprising the peak or regulated level is within a range defined by any two of the foregoing values (e.g., 50% -100%, 70% -95%, 80% -90% or 60% -95%, etc.). In some embodiments, sustained activation comprises sustaining or maintaining at least 50% of peak or regulated levels. In some embodiments, sustained activation comprises sustaining or maintaining at least 75% of peak or regulated levels. In some embodiments, sustained activation comprises sustaining or maintaining at least 90% of peak or regulated levels. In some embodiments, sustained activation comprises sustaining or maintaining at least 95% of peak or regulated levels.

In some embodiments, the engineered gene effectors disclosed herein (e.g., engineered gene activators) repress (e.g., alone or together with a heterologous endonuclease, such as a Cas or dCas protein, e.g., an inactivated variant of Un1Cas12f1 comprising the polypeptide sequence of SEQ ID NO: 2231) the expression level of the target gene in the cell as compared to the control.

In some embodiments, the cells provided herein can be referred to as target cells. In some embodiments, the systems and methods provided herein are applied to modify a target cell (e.g., to modify the expression profile of a target gene of a target cell, such as one or more genes in table 6). The target cells may include a variety of cell types. The target cells may be in vitro. The target cell may be in vivo. The target cells may be ex vivo. The target cell may be an isolated cell. The target cell may be a cell in an organism. The target cell may be an organism. The target cell may be a cell in a cell culture. The target cell may be one of a collection of cells. The target cell may be a mammalian cell or derived from a mammalian cell. The target cell may be a rodent cell or derived from a rodent cell. The target cell may be a human cell or derived from a human cell. The target cells may be prokaryotic cells or derived from prokaryotic cells. The target cell may be a bacterial cell or may be derived from a bacterial cell. The target cell may be an archaebacterium cell or derived from an archaebacterium cell. The target cell may be a eukaryotic cell or derived from a eukaryotic cell. The target cells may be pluripotent stem cells. The target cell may be a plant cell or derived from a plant cell. The target cell may be an animal cell or derived from an animal cell. The target cell may be an invertebrate cell or derived from an invertebrate cell. The target cell may be a vertebrate cell or derived from a vertebrate cell. The target cell may be a microbial cell or derived from a microbial cell. The target cell may be a fungal cell or derived from a fungal cell. The target cells may be from a particular organ or tissue.

The target cells may be stem cells or progenitor cells. The target cells may include stem cells (e.g., adult stem cells, embryonic stem cells, induced Pluripotent Stem (iPS) cells) and progenitor cells (e.g., cardiac progenitor cells, neural progenitor cells, etc.). The target cells may comprise mammalian stem cells and progenitor cells, including rodent stem cells, rodent progenitor cells, human stem cells, human progenitor cells, and the like. The cloned cells may comprise the progeny of the cells. The target cell may comprise a target nucleic acid. The target cell may be in a living organism. The target cell may be a genetically modified cell. The target cell may be a host cell.

The target cell may be a primary cell. For example, the primary cell culture may be passaged 0, 1, 2, 4, 5, 10, 15, or more times. The cell may be a unicellular organism. Cells may be grown in culture.

The target cell may be a diseased cell. The diseased cells may have altered metabolic, gene expression, and/or morphological characteristics. The diseased cells may be cancer cells, diabetic cells, and apoptotic cells. The diseased cell may be a cell from a diseased subject. Exemplary diseases may include blood disorders, cancers, metabolic disorders, ocular disorders, organ disorders, musculoskeletal disorders, heart diseases, and the like.

If the target cells are primary cells, they may be obtained from the individual by any method. For example, the white blood cells may be obtained by apheresis, white blood cell separation, density gradient separation, or the like. Cells from tissue (e.g., skin, muscle, bone marrow, spleen, liver, pancreas, lung, intestine, stomach, etc.) can be obtained by biopsy.

Non-limiting examples of cells that can be used as target cells include, but are not limited to, lymphocytes such as B cells, T cells (cytotoxic T cells, natural killer T cells, regulatory T cells, helper T cells), natural killer cells, cytokine-induced killer (CIK) cells, myeloid cells such as granulocytes (basophils, eosinophils, neutrophils/multi-lobular neutrophils), monocytes/macrophages, erythrocytes (reticulocytes), mast cells, platelets/megakaryocytes, dendritic cells, cells from the endocrine system including thyroid cells (thyroid epithelium, follicular paracellular), cells, Parathyroid cells (parathyroid main cells, eosinophils), adrenal cells (pheochromocytes), pineal cells (pineal gland cells), cells of the nervous system including glial cells (astrocytes, microglia), large-cell neurosecretory cells (Magnocellular neurosecretory cell), astrocytes, boettcher cells and pituitary (gonadotrophin cells, corticotropin cells, thyroid stimulating hormone cells, somatic cells, lactogen cells), cells of the respiratory system including lung cells (type I lung cells, Type II lung cells), clara cells, goblet cells, dust cells, cells of the circulatory system including cardiomyocytes, pericytes, cells of the digestive system including gastric cells (gastric host cells, parietal cells), goblet cells, pan' S cells, G cells, D cells, ECL cells, I cells, K cells, S cells, enteroendocrine cells including enterochromaffin cells, APUD cells, liver (hepatocytes, kupffer cells), cartilage/bone/muscle cells, bone cells including osteoblasts, osteocytes, osteoclasts, teeth (cementoblasts, ameloblasts), cartilage cells including chondroblasts, Chondrocytes, skin cells including hair cells, keratinocytes, melanocytes (nevi cells), muscle cells including muscle cells, urinary system cells including podocytes, periglomerular cells, mesangial/mesangial cells, perirenal tubular brush border cells, compact plaque cells, germ system cells including sperm, supporting cells, interstitial cells, ovum, and other cells including adipocytes, fibroblasts, tendon cells, epidermal keratinocytes (differentiated epidermal cells), epidermal basal cells (stem cells), nail and toenail keratinocytes, nail bed basal cells (stem cells), nail, Medullary hair stem cells, cortical hair stem cells, epidermal root sheath cells, huxley's layered root sheath cells, henle's layered root sheath cells, outer root sheath cells, hair matrix cells (stem cells), wet-layered barrier epithelial cells (WET STRATIFIED Barrier EPITHELIAL CELLS), surface epithelial cells of the multilayer squamous epithelium of the cornea, tongue, mouth, esophagus, anal canal, distal urethra and vagina, surface epithelial cells of the cornea, tongue, mouth, esophagus, anal canal, distal urethra and vagina, urothelial basal cells (stem cells), urothelial cells (lining bladder and urethra), and combinations thereof, Exocrine epithelial cells, salivary gland mucus cells (polysaccharide-rich secretions), salivary gland serous cells (glycoprotein-rich secretions), von Ebner's gland cells of the tongue (flushing taste buds), breast cells (milk secretion), lacrimal gland cells (lacrimal secretion), earwax gland cells of the ear (cerumen secretion), exocrine sweat gland dark cells (glycoprotein secretion), exocrine sweat gland clear cells (small molecule secretion), apocrine sweat gland cells (odor secretion, sex hormone sensitivity), moll gland cells of the eyelid (specialised sweat glands), sebaceous gland cells (lipid-rich sebum secretion), bowman's gland cells of the nose (irrigation of olfactory epithelium), and, Brunner's gland cells of the duodenum (enzyme and alkaline mucus), seminal vesicle cells (secretion of semen components including fructose for sperm motility), prostate cells (secretion of semen components), urinary tract bulbar gland cells (mucus secretion), bartholin's gland cells (vaginal lubrication secretion), littre gland cells (mucus secretion), endometrial cells (carbohydrate secretion), isolated goblet cells of the respiratory and digestive tracts (mucus secretion), gastric mucosa mucus cells (mucus secretion), gastric gland zymogen cells (pepsinogen secretion), gastric gland acid secretion cells (hydrochloric acid secretion), pancreatic gland acinar cells (bicarbonate and digestive enzyme secretion), and, Small intestine panus cells (lysozyme secretion), lung type II lung cells (surface active substance secretion), lung Clara cells, hormone secreting cells, pituitary anterior lobe cells, parent somatic cells, prolactin cells, thyroid stimulating hormone cells, gonadotrophin cells, corticotropin cells, pituitary intermediate cells, large cell nerve secreting cells, intestinal and respiratory tract cells, thyroid epithelial cells, follicular paracellular cells, parathyroid main cells, eosinophils, adrenal cells, pheochromocytes, testicular mesenchyme cells, follicular intimal cells, ruptured follicular corpus luteum cells, granulosa corpus luteum cells, follicular pericytes, Membranous corpus luteum cells, glomerular cells (renin secretion), renal compact plaque cells, metabolic and storage cells, cells of barrier function (lung, intestinal tract, exocrine glands and genitourinary tract), kidneys, type I lung cells (lining air cavities of the lung), pancreatic duct cells (acinar cells), (sweat glands, salivary glands, mammary glands, etc.) non-striated duct cells, (seminal vesicles, prostate, etc.) duct cells, epithelial cells lining closed internal body cavities, ciliated cells with propulsion function, extracellular matrix secreting cells, contractile cells, skeletal muscle cells, stem cells, myocardial cells, blood and immune system cells, erythrocytes (red blood cells), megakaryocytes (platelet precursors), Monocytes, connective tissue macrophages (types), epidermal langerhans cells, osteoclasts (in bone), dendritic cells (in lymphoid tissue), microglia (in central nervous system), neutrophils, eosinophils, basophils, mast cells, helper T cells, suppressor T cells, cytotoxic T cells, natural killer T cells, B cells, natural killer cells, reticulocytes, stem cells and committed progenitors of the blood and immune system (types), pluripotent stem cells, totipotent stem cells, induced pluripotent stem cells, adult stem cells, sensory conducting cells, autonomic neurons cells, Sensory and peripheral neuron support cells, central nervous system neurons and glial cells, lens cells, pigment cells, melanocytes, retinal pigment epithelial cells, germ cells, oogonial/oocyte, sperm cells, spermatocyte, spermatogonial cells (stem cells of spermatocyte), sperm, trophoblast or follicular cells.

In some embodiments, a method of controlling a target gene in a cell comprises contacting a cell (e.g., a cell of interest for regulating expression of the target gene) with any of the systems of the present disclosure, wherein contacting is performed in vitro. In some embodiments, a method of controlling a target gene in a cell comprises contacting the cell with a combination of polynucleotides of the present disclosure, wherein contacting is performed in vitro. In some embodiments, a method of controlling a target gene in a cell comprises contacting a cell (e.g., a cell of interest for regulating expression of the target gene) with any of the systems of the present disclosure, wherein the contacting is performed ex vivo. In some embodiments, a method of controlling a target gene in a cell comprises contacting the cell with a combination of polynucleotides of the present disclosure, wherein the contacting is performed ex vivo.

In some embodiments, the cells (or target cells) may be engineered to comprise (or exhibit) any of the systems or compositions disclosed herein, or may be treated in vitro or ex vivo by any of the methods disclosed herein, and then administered to a subject, e.g., for treating or inhibiting a disorder in a subject. For example, any subject's modified cell product can be administered to a subject to treat or inhibit a disorder of the subject's body tissue. In some embodiments, the cells may reside in a subject, and either system or a composition thereof may be administered to the subject, thereby contacting the system/composition with the cells (e.g., to engineer the cells with the system/composition).

In some embodiments, any of the compositions disclosed herein can be administered to a subject orally, intraperitoneally, intravenously, intraarterially, transdermally, intramuscularly, liposomally, locally by catheter or stent delivery, subcutaneously, intrafat, or intrathecally. In some embodiments, the compositions and systems provided herein (including polynucleotides encoding the compositions and systems, e.g., contained in AAV vectors) can be administered to a subject by intravenous administration.

The engineered gene effectors, fusion proteins, polynucleotides, systems, and/or combinations disclosed herein may be provided in compositions (e.g., pharmaceutical compositions) suitable for administration to humans. Furthermore, such compositions may be suitable for administration to any other animal, such as a non-human animal (e.g., a non-human mammal). It is well known to modify pharmaceutical compositions suitable for administration to humans to render the compositions suitable for administration to a variety of animals, and a ordinarily skilled veterinary pharmacologist may design and/or make such modifications using only routine experimentation, if any. Subjects contemplated for administration of the pharmaceutical compositions include, but are not limited to, humans and/or other primates, mammals, including commercially relevant mammals, such as cows, pigs, horses, sheep, cats, dogs, mice and/or rats, and/or birds, including commercially relevant birds, such as poultry, chickens, ducks, geese and/or turkeys.

The heterologous endonuclease in the system may be provided in any suitable form. For example, the heterologous endonuclease may be provided in the form of a protein, such as a heterologous endonuclease alone, or in complex with a guide nucleic acid as a ribonucleoprotein. The heterologous endonuclease may be provided in the form of a complex, for example, complexed with a guide nucleic acid and/or one or more heterologous gene effectors of the present disclosure. The heterologous endonuclease may be provided in the form of a nucleic acid encoding at least the heterologous endonuclease, such as RNA (e.g., messenger RNA (mRNA)) or DNA. Nucleic acids encoding at least heterologous endonucleases can be codon optimized for efficient translation into a protein (e.g., optimized human codons) in a particular cell or organism.

The nucleic acids, fragments or derivatives thereof disclosed herein encoding at least heterologous endonucleases can be stably integrated into the cell genome. The nucleic acid encoding at least the heterologous endonuclease may be operably linked to a promoter, e.g., a promoter that is constitutively or inductively activated in the cell. The nucleic acid encoding at least the heterologous endonuclease may be operably linked to a promoter in an expression construct. The expression construct may comprise any nucleic acid construct capable of directing expression of a gene or other nucleic acid sequence of interest (e.g., at least a heterologous endonuclease), and such nucleic acid sequence of interest may be transferred to a target cell.

In some embodiments, a heterologous endonuclease disclosed herein can bind to a single guide RNA (sgRNA) to activate or repress transcription of a target gene (e.g., a target endogenous gene), e.g., to a heterologous gene effector disclosed herein. The sgrnas can be introduced into cells expressing the heterologous endonucleases or variants thereof provided herein. In some cases, such cells can comprise one or more different sgrnas that target the same target gene (e.g., target endogenous gene) or target gene regulatory sequence. In other cases, the sgrnas target different nucleic acids in the cell (e.g., different target genes, different target gene regulatory sequences, or different sequences within the same target genes or target gene regulatory sequences).

In some embodiments, the target nucleic acid of a heterologous endonuclease disclosed herein can be dsDNA. In these embodiments, dsDNA targeting specificity is determined, at least in part, by two parameters, targeting the gRNA spacer of the protospacer in the target dsDNA (the sequence in the target dsDNA corresponding to the gRNA spacer on the non-complementary DNA strand), and the short sequence immediately 5' (upstream) of the protospacer on the non-complementary DNA strand, i.e., the Protospacer Adjacent Motif (PAM). In some embodiments, PAM is 5'-TTTG-3' or 5'-TTTA-3'. In some embodiments, PAM is 5'-TTTG-3'. In some embodiments, PAM is 5'-TTTA-3'.

In some embodiments, the target nucleic acid of a heterologous endonuclease disclosed herein can be RNA. In these embodiments, RNA targeting specificity is determined, at least in part, by the gRNA spacer targeting the protospacer-like sequence in the target RNA (the sequence in the target RNA that is complementary to the gRNA spacer), and is independent of the sequence immediately 5' (upstream) of the protospacer-like sequence. In some embodiments, the heterologous endonuclease may be further capable of targeting a dsDNA molecule, wherein the gRNA spacer is selected such that it targets a protospacer in the target dsDNA molecule, said protospacer having a PAM selected from the group consisting of 5'-TTTG-3' and 5 '-TTTA-3'. In other embodiments, the heterologous endonuclease is not capable of targeting a dsDNA molecule, wherein the gRNA spacer is selected such that none of the protospacer sequences in the dsDNA molecule targeted by the gRNA spacer have PAM selected from the group consisting of 5'-TTTG-3' and 5 '-TTTA-3'.

In some embodiments, a heterologous polypeptide (e.g., and/or a complex comprising a heterologous polypeptide) comprising an engineered gene effector and a heterologous endonuclease can regulate expression and/or activity of a target gene (e.g., a target endogenous gene). In some embodiments, the heterologous polypeptide and/or complex thereof can edit the sequence of a nucleic acid (e.g., a gene and/or gene product). Variants of the nuclease activity of the heterologous endonuclease can edit the nucleic acid sequence by creating a double-strand break or single-strand break in the target polynucleotide.

In some embodiments, a heterologous polypeptide (e.g., and/or a complex comprising a heterologous polypeptide) comprising an engineered gene effector and a heterologous endonuclease can create a double strand break in a target polynucleotide (e.g., DNA). Double strand breaks in DNA can cause DNA break repair, which allows for the introduction of genetic modifications (e.g., nucleic acid editing). In some embodiments, the nuclease induces site-specific single-stranded DNA breaks or nicks, thereby causing HDR.

Double strand breaks in DNA can cause DNA break repair, which allows for the introduction of genetic modifications (e.g., nucleic acid editing). DNA break repair may occur through non-homologous end joining (NHEJ) or Homology Directed Repair (HDR). In HDR, a donor DNA repair template or template polynucleotide comprising sites flanking homology arms of the target DNA may be provided.

In some embodiments, a heterologous polypeptide (e.g., and/or a complex comprising a heterologous polypeptide) comprising an engineered gene effector and a heterologous endonuclease does not create a double strand break in a target polynucleotide (e.g., DNA). The binding of the heterologous polypeptide or a complex comprising the heterologous polypeptide (e.g., a complex comprising a nuclease-deficient variant of a heterologous endonuclease and a guide RNA) without nucleic acid cleavage can be sufficient to regulate expression (e.g., enhance or repress) of a target gene (e.g., an endogenous target gene).

In some embodiments, the methods disclosed herein (e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide into a cell or population of cells) modulate (e.g., increase) expression of a target gene by at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 2-fold, at least about 3-fold, at least about 4-fold, at least about 5-fold, at least about 6-fold, at least about 7-fold, at least about 8-fold, at least about 9-fold, at least about 10-fold, at least about 11-fold, at least about 12-fold, at least about 13-fold, at least about 14-fold, at least about 15-fold, at least about 20-fold, at least about 30-fold, at least about 40-fold, at least about 50-fold, at least about 60-fold, at least about 70-fold, at least about 80-fold, at least about 90-fold, at least about 100-fold, at least about 150-fold, at least about 200-fold, at least about 250-fold, at least about 300-fold, at least about 350-fold, at least about 400-fold, at least about 500-fold, at least about 600-fold, at least about 700-fold, at least about 800-fold, or at least about 1000-fold.

In some embodiments, the methods disclosed herein (e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide into a cell or population of cells) modulate (e.g., increase) expression of a target gene by at most about 50%, at most about 60%, at most about 70%, at most about 80%, at most about 90%, at most about 2-fold, at most about 3-fold, at most about 4-fold, at most about 5-fold, at most about 6-fold, at most about 7-fold, at most about 8-fold, at most about 9-fold, at most about 10-fold, at most about 11-fold, at most about 12-fold, at most about 13-fold, at most about 14-fold, at most about 15-fold, at most about 20-fold, at most about 30-fold, at most about 40-fold, at most about 50-fold, at most about 60-fold, at most about 70-fold, at most about 80-fold, at most about 90-fold, at most about 100-fold, at most about 150-fold, at most about 200-fold, at most about 250-fold, at most about 300-fold, at most about 350-fold, at most about 400-fold, at most about 500-fold, at most about 600-fold, at most about 700-fold, at most about 800-fold, at most about 1000-fold, at most about 2000-fold, at most about 2000-fold or at most about 2000-fold).

In some embodiments, the methods disclosed herein (e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide into a cell or population of cells) modulate (e.g., increase) the expression of a target gene by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 2-fold, about 3-fold, about 4-fold, about 5-fold, about 6-fold, about 7-fold, about 8-fold, about 9-fold, about 10-fold, about 11-fold, about 12-fold, about 13-fold, about 14-fold, about 15-fold, about 20-fold, about 30-fold, about 40-fold, about 50-fold, about 60-fold, about 70-fold, about 80-fold, about 90-fold, about 100-fold, about 150-fold, about 200-fold, about 250-fold, about 300-fold, about 350-fold, about 400-fold, about 500-fold, about 600-fold, about 700-fold, about 800-fold, about 900-fold, about 1000-fold, about 1500-fold, about 2000-fold, about 3000-fold, about 5000-fold, or about 5000-fold) in a cell population.

In some embodiments, the methods disclosed herein (e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide into a cell or cell population) modulate (e.g., increase) expression of a target gene from below a detection limit to a detectable level.

In some embodiments, the degree of change in expression is relative to prior to introducing the system of the present disclosure (e.g., a complex comprising an engineered gene effector and a heterologous polypeptide) into a cell or cell population. In some embodiments, the degree of change in expression is relative to a corresponding control cell or cell population not treated with the system of the present disclosure. In some embodiments, the degree of change in expression is relative to a corresponding control cell or cell population treated with an alternative to the system of the present disclosure.

In some embodiments, the methods disclosed herein modulate (e.g., increase) the activity level of a target gene, e.g., after introducing a complex comprising an engineered gene effector and a heterologous polypeptide (comprising a heterologous endonuclease disclosed herein) into a cell or cell population. Depending on the functional characteristics of the target gene, the level of activity may be determined by suitable functional assays for the target gene in question. For example, the level of activity of a target gene that is a mitogen may be determined by measuring cell proliferation, the level of activity of a target gene that induces apoptosis may be determined by an annexin V assay or other suitable cell death assay, and the level of activity of an anti-inflammatory cytokine may be determined by an LPS-induced cytokine release assay.

In some cases, the methods of the present disclosure result in a change in the expression level and/or activity level of a target gene (e.g., a target endogenous gene) that is longer lasting than can be achieved with alternative compositions and methods (e.g., via RNAi repression, such as using siRNA). In some embodiments, sustained modulation of gene expression (e.g., sustained gene activation or sustained gene repression) is beneficial as compared to transient modulation.

In some embodiments, the methods disclosed herein modulate (e.g., increase) the expression level and/or activity level of a target gene for at least about 1 hour, at least about 2 hours, at least about 3 hours, at least about 4 hours, at least about 5 hours, at least about 6 hours, at least about 7 hours, at least about 8 hours, at least about 9 hours, at least about 10 hours, at least about 12 hours, at least about 14 hours, at least about 18 hours, at least about 20 hours, at least about 1 day, at least about 2 days, at least about 3 days, at least about 4 days, at least about 5 days, at least about 6 days, at least about 7 days, at least about 8 days, at least about 9 days, at least about 10 days, at least about 14 days, at least about 28 days, at least about 5 weeks, at least about 6 weeks, at least about 7 weeks, at least about 8 weeks, at least about 9 weeks, at least about 10 weeks, at least about 12 weeks, at least about 14 weeks, at least about 18 weeks, at least about 20 weeks, at least about 26 weeks, or at least about 5 months, at least about 6 months, at least about 12 months, or more.

In some embodiments, the methods disclosed herein modulate (e.g., increase) the expression level and/or activity level of a target gene (e.g., a target endogenous gene) above a certain threshold for up to about 1 hour, up to about 2 hours, up to about 3 hours, up to about 4 hours, up to about 5 hours, up to about 6 hours, up to about 7 hours, up to about 8 hours, up to about 9 hours, up to about 10 hours, up to about 12 hours, up to about 14 hours, up to about 18 hours, up to about 20 hours, up to about 1 day, up to about 2 days, up to about 3 days, up to about 4 days, up to about 5 days, up to about 6 days, up to about 7 days, up to about 8 days, up to about 9 days, up to about 10 days, up to about 28 days, up to about 5 weeks, up to about 6 weeks, up to about 7 weeks, up to about 8 weeks, up to about 9 weeks, up to about 10 weeks, up to about 12 weeks, up to about 14 weeks, up to about 18 weeks, up to about 26 months, up to about 12 months, up to about 5 months, up to about 12 months, or more.

In some embodiments, the methods disclosed herein modulate (e.g., increase) the expression level and/or activity level of a target gene (e.g., a target endogenous gene) above a certain threshold for about 1 hour, about 2 hours, about 3 hours, about 4 hours, about 5 hours, about 6 hours, about 7 hours, about 8 hours, about 9 hours, about 10 hours, about 12 hours, about 14 hours, about 18 hours, about 20 hours, about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 6 days, about 7 days, about 8 days, about 9 days, about 10 days, about 14 days, about 21 days, about 28 days, about 5 weeks, about 6 weeks, about 7 weeks, about 8 weeks, about 9 weeks, about 10 weeks, about 12 weeks, about 14 weeks, about 18 weeks, about 20 weeks, about 26 weeks, about 5 months, about 6 months, about 9 months, or about 12 months.

Computer-implemented method for generating functional biological sequences

Also provided herein are computer-implemented methods for generating functional biological sequences. Referring to fig. 21A, a non-limiting embodiment of a computer-implemented method for generating a functional biological sequence is provided. The method may include, at block 2110a, providing an fitness function trained on a biological data set comprising functionally determined biological sequences having a fixed length. The method may further include providing, at block 2120a, a plurality of different sequences comprising a fixed length in a computer, each sequence associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of the temperature gradient. with respect to computer-implemented methods, as used herein, "sequence" refers to the order of monomer units in a polymer molecule, wherein the monomer units are of the same type (e.g., amino acids, nucleotides, etc.) as are present in the functionally determined biological sequence of the biological dataset. As used herein, "temperature gradient" means a series of monotonically increasing or decreasing temperature values. Any suitable temperature gradient may be used. In some embodiments, the temperatures are geometrically spaced apart in a temperature gradient. In some embodiments, each of the plurality of different sequences is associated (e.g., randomly associated) with a different temperature of the temperature gradient. At block 2130a, the method may include, in parallel, by the computer, in a plurality of different sequences (1) selecting one or more random locations for introducing substitutions in one or more of the plurality of different sequences, and for each of the one or more sequences, evaluating a first fitness change resulting from introducing substitutions at the one or more randomly selected locations, and based on the evaluated first fitness change, And optionally further accepting or rejecting substitutions based on a temperature associated with the sequences, and/or (2) selecting one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a successive temperature of a temperature gradient, and for each selected pair, selecting one or more domains for exchange between the sequences of the selected pair, and evaluating a difference in fitness of the sequences of the selected pair due to the exchange of one or more domains, and accepting or rejecting one or more domain exchanges between the selected pair based on the difference in fitness and the temperature associated with each sequence of the selected pair. The method may include, at block 2140a, iteratively performing block 2130a, wherein, in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domains of a previous iteration are swapped into a plurality of different sequences, thereby generating one or more functional sequences having fitness that reaches or is above a desired fitness threshold. As used herein, "functionally determined" refers to a biological sequence associated with one or more functional features of interest, e.g., experimentally determined functional features. Without limitation, a biological sequence may be functionally defined when the effect (or lack of effect) of placing the biological sequence in a biological context (e.g., expressed in a cell, expressed in vitro, expressed in vivo, etc.) is determined or known. Any suitable functional feature may be used. The functional characteristics of a biological sequence are any suitable cellular process that can be determined experimentally. In some embodiments, the functional features used to functionally define a biological sequence are transcription, translation, DNA methylation, DNA demethylation, cell death, cell signaling, mitosis, meiosis, energy metabolism, differentiation or dedifferentiation, and the like.

In some embodiments, after performing the predetermined maximum number of iterations of block 2130a, the method terminates. In some embodiments, the predetermined maximum number of iterations is, is about, is at least, or is on the order of 10³、10⁴、10⁵、10⁶、10⁷、10⁸、10⁹、10¹⁰、10¹¹ or more, or optionally, the predetermined maximum number of iterations is within a range defined by any two of the foregoing values (e.g., 10 ³-10¹¹、10⁴-10¹⁰、10⁵-10⁹、10⁶-10⁸, etc.). In some embodiments, the predetermined maximum number of iterations is on the order of 10 ⁶. In some embodiments, the predetermined maximum number of iterations is on the order of 10 ⁷. In some embodiments, the predetermined maximum number of iterations is on the order of 10 ⁸. In some embodiments, the predetermined maximum number of iterations is on the order of 10 ⁹. In some embodiments, the predetermined maximum number of iterations is on the order of 10 ¹⁰. In some embodiments, the method terminates after generating one or more sequences having a fitness above a predetermined threshold fitness based on a fitness function. In some embodiments, after performing the minimum number of iterations of block 2130a, the method terminates after generating one or more sequences having a fitness based fitness function above a predetermined threshold fitness.

Any suitable number of random positions may be selected for introduction at block 2130a (1) (e.g., each iteration). In some embodiments, the number of random positions selected per iteration is or is at least 0, 1, 2,3, 4, 5, 6, 7, 8, 9, 10, or more, or optionally is a number within a range defined by any two of the foregoing values (e.g., 0-10, 0-5, 0-6, 1-3, 1-5, 5-10, or 2-8, etc.). In some embodiments, the number of random positions selected per iteration is in the range of 1-5. In some embodiments, the number of random positions selected per iteration is 1. In some embodiments, the number of random positions selected per iteration is, is about, or at least is, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or more of a fixed length, or is optionally a percentage (e.g., 0.01% -10%, 0.05% -5%, 0.1% -3%, 1% -5% or 1% -10%, etc.) within a range defined by any two of the foregoing values of fixed length. In some embodiments, the number of random positions selected per iteration is in the range of about 1% to about 5% of the fixed length. in some embodiments, the number of random positions selected per iteration is about 1% of the fixed length. In some embodiments, at least 1 random position is selected at block 2130a (1) using a uniform probability distribution. In some implementations, at least 1 random position is selected at block 2130a (1) with a predetermined probability for each iteration. Any suitable predetermined probability may be used. In some embodiments, the predetermined probability is, is about or at most 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or higher, or optionally, the predetermined probability is within a range defined by any two of the foregoing values (e.g., 1% -10%, 10% -20%, 20% -30%, 30% -40%, 40% -50%, 50% -60%, 60% -70%, 70% -80%, 80% -90% or 90% -95%, etc.). In some embodiments, no position is selected for replacement in a given iteration. Each selected substitution at a random position, if any, may be a substitution of a residue (e.g., an amino acid residue) in the starting sequence (e.g., a residue at a selected position in each iteration prior to introduction of any substitution) with any other residue. In some embodiments, the substitution is random. For example, for an amino acid sequence, an alanine at a randomly selected position can be selected with equal probability to be replaced with any of the other 19 naturally occurring amino acid residues. In some embodiments, the substitution is a conservative amino acid substitution. In some embodiments, the substitution is a non-conservative amino acid substitution. In some embodiments, the one or more randomly selected locations are selected uniformly over a fixed length, e.g., over multiple iterations. The selected locations and/or properties of the substitutions may be the same or different in a plurality of different sequences evaluated in parallel (e.g., in the same iteration). In some embodiments, the selection of the number, location, and/or nature of substitutions in one sequence does not affect the selection of the number, location, and/or nature of substitutions for any other sequence in the plurality of different sequences evaluated in parallel (e.g., in the same iteration).

At block 2130a, the method may include any suitable criteria for accepting substitutions or accepting domain exchanges at one or more randomly selected locations. In some embodiments, accepting or rejecting a substitution at block 2130a option (1) includes accepting a substitution when the fitness of the sequence after the substitution is introduced (e.g., all substitutions for the iteration) is greater than the fitness of the sequence before the substitution is introduced (e.g., before any substitution is introduced in the iteration). For example, in fig. 9A, random positions in the starting sequence may be selected for introducing mutations (as an alternative). The fitness of the starting sequence and the mutant sequence may be determined (e.g., based on a fitness function), and if the fitness of the mutant sequence is higher than the starting sequence, the mutation at the selected position may be accepted and the mutant sequence may be used as a starting sequence for the next iteration, exchange domain, and/or crossover of the selection and evaluation of mutations (as described herein), or the method may terminate as one of the outputs if the desired fitness is reached by the mutant sequence and/or a predetermined number of iterations have been performed.

In some embodiments, accepting or rejecting a substitution at block 2130a option (1) includes accepting or rejecting a substitution at one or more randomly selected locations based on a probability weighted by a ratio of the fitness of the sequence after the substitution was introduced (e.g., all substitutions for the iteration) to the fitness of the sequence before the substitution was introduced (e.g., before any substitution was introduced in the iteration). In some embodiments, the method includes accepting or rejecting substitutions at one or more randomly selected locations based on Boltzmann Metropolis-hastins acceptance criterion r _mh. In some embodiments, the substitution is accepted with a probability of min (1, r _mh), wherein,Where f (i) is the fitness of sequence i, f (j) is the fitness of sequence j that contains substitutions at randomly selected locations of sequence i, and T is the temperature associated with sequence i. For example, in fig. 9B, random positions in the starting sequence may be selected for introducing mutations (as an alternative). The fitness of the starting sequence and the mutant sequence may be determined (e.g., based on a fitness function), and if the fitness of the mutant sequence is lower than the starting sequence, the mutation at the selected position may in some cases be rejected and the same starting sequence used in the next iteration, domain of exchange, and/or crossover of the mutation (as described herein) is selected and evaluated, or if a predetermined number of iterations has been performed, the method may terminate the mutant sequence as one of the outputs. Or if the fitness of the mutated sequence is lower than the starting sequence, the mutation at the selected position may be accepted with a probability proportional to the decrease in fitness, e.g., using Boltzmann Metropolis-hasts acceptance criterion r _mh. As another example, in fig. 9C, random positions in the starting sequence are selected for introducing mutations (as alternatives). The fitness of the starting sequence and the mutant sequence may be determined (e.g., based on a fitness function), and the fitness of the mutant sequence may be found to be lower (0.007) than the starting sequence (0.01). The mutation at the selected position is accepted and the mutated sequence can be used as the starting sequence in the next iteration, wherein a random position can be selected for introducing the mutation. The fitness (e.g., based on a fitness function) of the starting sequence (i.e., the mutant sequence from the previous iteration) and the mutant sequence of the current iteration may be determined, and the fitness (e.g., 0.4) of the mutant sequence may be found to be higher than the starting sequence (e.g., 0.007).

At block 2130a (2) (e.g., each iteration), any domain between any two sequences (or pairs of sequences) associated with consecutive temperatures of a temperature gradient may be selected for exchange. As used herein, domain exchange means exchanging (a) one or more consecutive residues (e.g., amino acid residues) along a fixed length in one sequence associated with a temperature, (b) corresponding one or more consecutive residues at the same position along a fixed length in another sequence associated with a temperature in a temperature gradient immediately preceding or following the temperature associated with the first sequence. In some embodiments, block 2130a (2) involves selecting one or more pairs of the plurality of different sequences for exchange of complete sequences (e.g., the selected domain comprises the complete sequence of the selected pair) such that temperatures of consecutive temperatures associated with the sequence of the selected pair are exchanged. In some embodiments, when block 2130a (2) involves selecting one or more pairs of the plurality of different sequences for exchange of a complete sequence, the selecting the one or more pairs is the same step as selecting for exchange of one or more domains.

Any suitable pair of sequences associated with successive temperatures of the temperature gradient may be used or selected for exchange (e.g., each iteration). For example, for N sequence chains [0, 1, ], i, ], N ] with corresponding temperature gradients [ T ₀, T₁, . . . , T_i, . . . , T_N ], such that for i > j T _i ≥ T_j, the selected pair may include sequences i and j corresponding to T _i and T _j, respectively, such that j=i±1. Any suitable number of sequence pairs (e.g., each iteration) may be selected from a plurality of different sequences. In some embodiments, the number of pairs selected per iteration is, about or at most, 1, 5, 10, 20, 50, 100, 150, 200, 500, 1000, 2000, 5000, 10000 or more, or optionally, the number of pairs per iteration is within a range defined by any two of the foregoing values (e.g., 1-10000, 50-5000, 100, 10000, or 1000-5000). In some embodiments, the number of pairs selected per iteration is at most 3 pairs. In some embodiments, the number of pairs selected per iteration is 1 pair. The domains selected for exchange may be located at any suitable position along a fixed length. The domain selected for exchange may comprise any suitable number of consecutive residues. In some embodiments, the domain selected for exchange comprises, comprises about or comprises up to 1,2, 3, 4, 5,6, 7,8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, or more consecutive residues, or optionally, is comprised within a range defined by any two of the foregoing values (e.g., 1-75, 1-10, 10-20, 20-30, 1-75, 30-40, 40-50, 50-60, 60-70, 1-50, etc.). in some embodiments, the complete sequence of each selected pair is exchanged (e.g., the temperatures associated with each sequence of the selected pair are exchanged). In some embodiments, the domain selected for exchange comprises, about, or comprises 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 60%, 70%, 80%, 90%, 95%, 98%, or 100% contiguous residues of length, about, or at most about, or of a fixed length, or optionally comprises a percentage of length to fixed length within a range defined by any two of the foregoing values (e.g., 1% -100%, 5% -40%, 10% -30%, 5% -30%, 50% -100% or 1% -25%, etc.).

In some embodiments, accepting or rejecting the exchange of one or more domains at block 2130a option (2) includes accepting the exchange of the selected domain between the selected pair when the fitness of the sequence after the exchange associated with a lower temperature of the consecutive temperature is greater than the fitness of the sequence after the exchange associated with a higher temperature of the consecutive temperature. In some embodiments, accepting or rejecting the exchange of one or more domains at block 2130a option (2) includes accepting the exchange of a selected domain between the selected pair when the fitness of the sequence associated with a lower temperature of the consecutive temperature after the exchange is greater than the fitness of the sequence associated with a higher temperature of the consecutive temperature after the exchange, wherein the selected domain comprises the complete sequence of the selected pair. In some embodiments, the method includes accepting an exchange of the selected domains between the selected pairs based on a probability inversely proportional to a difference between temperatures associated with each sequence of the pairs and a ratio of fitness of the exchanged sequence pairs. In some embodiments, the method comprises accepting an exchange of selected domains between the selected pairs based on a probability inversely proportional to a difference between temperatures associated with each sequence of the pairs, and a ratio of fitness of exchanged sequence pairs, wherein the selected domains comprise the complete sequence of the selected pair. In some embodiments, the exchange of selected domains between the pair is accepted or rejected based on the parallel tempering criterion r _re. In some embodiments, the exchange of selected domains between the pairs is accepted or rejected based on the parallel tempering criterion r _re, wherein the selected domains comprise the complete sequence of the selected pairs. In some embodiments, the domain comprises the complete sequence, then the selected sequence is accepted for exchange with probability min (1, r _re), wherein Where f (i) is the fitness of the swapped sequence i and f (j) is the fitness of the swapped sequence j. In some embodiments, if the domain contains a portion of a sequence, then the selected domain is accepted for exchange with probability min (1, r _c), where. Here, i ₁ and j ₁ are sequences before domain exchange, respectively, and i ₂、_.j₂ is a sequence after domain exchange, respectively. For both temperatures T _i and T _j, i ₂、j₂ and i ₁、j₁ are ordered such that f (i ₂)>f(i₁) and f (j ₂)>f(j₁).

In some embodiments, at block 2130a, the method includes (3) selecting a crossover site between one or more pairs of the plurality of different sequences, and for each of the one or more pairs in which a crossover site was selected, evaluating a second fitness change for each sequence of the selected pair due to crossover at the crossover site, and accepting or rejecting crossover at the selected crossover site based on the second fitness change and a temperature associated with each sequence of the selected pair. Any suitable pair of a plurality of different sequences may be selected for interleaving. In some embodiments, the sequence pairs are randomly selected from a plurality of different sequences. The crossover point may be any suitable location along the fixed length. In some embodiments, the crossover sites are randomly selected along a fixed length (e.g., regardless of the position of the crossover site selected for any other sequence pair). In some embodiments, the method includes accepting or rejecting the crossover at the selected crossover site based on a probability weighted by a ratio of the second fitness change for each sequence of the selected pair. In some embodiments, the method includes accepting or rejecting the intersection at the selected intersection site based on an intersection criterion r _c. In some embodiments, the crossover is accepted with a probability of min (1, r _c), whereWherein for the sequence pair i ₁ and j ₁,i₂ is the sequence of i ₁ up to the crossover site and the sequence of j ₁ after the crossover site, j ₂ is the sequence of j ₁ up to the crossover site and the sequence of i ₁ after the crossover site, and for the two temperatures T _i and T _j, i ₂、j₂ and i ₁、j₁ are ordered such that f (i ₂)>f(i₁) and f (j ₂)>f(j₁). For example, in fig. 9D, pairs of sequences are selected, and crossover sites may be selected for crossover between the selected pairs of sequences. To determine whether to accept or reject a crossover at a selected crossover site, the fitness change between the two sequences after the selected domain crossover is based on a second fitness change for each sequence of the selected pair due to the crossover at the crossover site and a temperature associated with each sequence of the selected pair, e.g., a weighted probability based on a ratio of the fitness changes for each sequence of the selected pair.

In some embodiments, at least one of the one or more functional sequences produced has a fitness based on a fitness function that is greater than the fitness of each of the plurality of different sequences prior to any iteration of (c). In some embodiments, at least one of the one or more functional sequences produced has a fitness based on a fitness function that is greater than a fitness of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or about 100% of the plurality of different sequences prior to any iteration of (c), or optionally, a fitness of a percentage of the plurality of different sequences prior to any iteration of (c) within a range (e.g., 10% -100%, 20% -95%, 30% -80%, 40% -100%, etc.) defined by any two of the foregoing values. In some embodiments, the desired fitness threshold is based on fitness associated with a corresponding sequence of the plurality of different sequences in (b). In some embodiments, the desired fitness threshold is based on a maximum fitness among a plurality of different sequences. In some embodiments, the desired fitness threshold is (e.g., prior to any iteration of (c)) a factor of 1.1, 1.2, 1.5, 2, 2.5, 3, 4,5, 6, 7, 8, 9, 10, 20, 50,100, or more of the greatest fitness among the plurality of different sequences, or, optionally, is (e.g., prior to any iteration of (c)) a factor of the greatest fitness among the plurality of different sequences within a range defined by any two of the foregoing values (e.g., 1.1-100, 1.2-50, 1.5-50, 5-100, etc.).

Any suitable sequence may be used as the plurality of different sequences. In some embodiments, the plurality of different sequences comprises a plurality of different, fixed length naturally occurring sequences. In some embodiments, the plurality of different sequences comprises a plurality of fixed length random sequences.

Also provided herein are computer-implemented methods for generating or generating a functional biological sequence. In one aspect, a computer-implemented method includes evaluating, by a computer, sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functional (or functionally determined) biological sequences having a fixed length. The computer-implemented method may further comprise replacing, by a computer, one or more random residues in the sequence to generate the mutated sequence. The computer-implemented method may further comprise evaluating, by the computer, the mutant sequence based on the fitness function. The computer-implemented method may further include collecting, by the computer, the functional sequences accepted by the fitness function.

In some cases, the computer-implemented method further comprises randomly exchanging, by the computer, one or more subsequences from the mutated sequence with different sequences of the plurality of sequences.

In some cases, the fitness function comprises a threshold selected from the group consisting of a binary threshold, a numeric threshold, a multi-class threshold, a confidence threshold, a decision threshold, and any combination thereof. In some cases, the functional sequence is accepted by the fitness function when the fitness score assigned to the functional sequence by the fitness function exceeds a threshold.

In any of the computer-implemented methods herein, in some cases, the functional (or functionally defined) biological sequence may comprise an amino acid sequence or a nucleotide sequence of a protein or peptide. The protein or peptide may be any protein or peptide of interest, including any protein or peptide having a biological function. Non-limiting examples of protein or peptide sequences that can be generated using the computer-implemented methods provided herein include epigenetic modulators, transcription factors, enzymes, nucleases, agonists, antagonists, regulatory factors, and inhibitors. In some embodiments, the functionally or functionally defined biological sequence comprises a transcriptional activator. In some embodiments, the functionally or functionally determined biological sequence comprises an engineered gene effector.

In any of the computer-implemented methods herein, in some cases, the functional biological sequence can comprise an amino acid sequence, a nucleotide sequence, or both. The functional biological sequence or functionally defined sequence may be of any suitable length. In some embodiments, the functionally or functionally defined biological sequence comprises an amino acid sequence. In some cases, the functionally or functionally determined biological sequence may comprise an amino acid sequence, and the fixed length may be at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60, at least 65, at least 70, at least 75, at least 80, at least 85, at least 90, at least 95, at least 100, at least 105, at least 110, at least 115, at least 120, at least 125, at least 130, at least 140, at least 150, or at least 200 amino acids, or at most 500, at most 300, at most 200, at most 150, at most 120, at most 100, at most 95, at most 90, at most 85, at most 75, or at most 70 amino acids, optionally, the fixed length is within a range defined by any two of the foregoing values (e.g., 30-500 amino acids, 50-300 amino acids, 50-200 amino acids, 75-95 amino acids, 80-90 amino acids, or 60-150 amino acids, etc.).

In any of the computer-implemented methods herein, in some cases, the fitness function is based on one or more machine learning models. The machine learning model may be, but is not limited to, a supervised machine learning model, an unsupervised machine learning model, a reinforcement learning model, a deep learning model, a transfer learning model, or any combination thereof. In some cases, the one or more machine learning models may be, but are not limited to, classification models, regression models, convolutional Neural Networks (CNNs), recurrent Neural Networks (RNNs), limit gradient boosting (XGBoost), long-term memory networks, generation countermeasure networks (GANs), automatic encoders, transformer networks, evolutionary Monte Carlo, or any combination thereof. In some embodiments, the fitness function is based on an integrated model comprising CNNs and XGBoost.

In any of the computer-implemented methods herein, in some embodiments, the method includes evaluating, by a computer, the biological data set to generate the fitness function, the evaluating including generating a sequence embedding from a Large Protein Language Model (LPLM) based on the biological data set, and training a machine learning model with the generated sequence embedding as input. In some embodiments LPLM comprises an Evolutionary Scale Modeling (ESM) language model, optionally wherein LPLM comprises ESM-2. In some implementations, the machine learning model includes an integrated model of more than two different models. In some embodiments, the integrated model includes a decision tree model and a convolutional neural network. Any suitable decision tree model and convolutional neural network may be used for the integrated model. In some embodiments, the integrated model comprises CNNs and XGBoost.

In any of the computer-implemented methods herein, in some embodiments, the biological dataset comprises up to about 10 ⁵ or on the order of about 10 ⁵ functionally defined biological sequences. In some embodiments, the biological data set comprises, comprises about, comprises at least, or comprises on the order of 10 ³, 10 ⁴, 10 ⁵, 10 ⁶, 10 ⁷ or more functionally defined biological sequences, or optionally, comprising a functionally defined number of biological sequences within a range defined by any two of the foregoing values (e.g., 10 ³-10⁷, 10 ⁴-10⁷, 10 ⁴-10⁶, 10 ⁵-10⁶, etc.). In some embodiments, up to 5% of the functionally determined biological sequences comprise functional sequences (e.g., sequences associated with, or determined or known to have, at least some of the desired functions in a relevant context). In some embodiments, the proportion of functional sequences among functionally defined biological sequences of a biological dataset is, is about or at most 0.01%, 0.02%, 0.05%, 0.1%, 0.2%, 0.5%, 0.75%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or more, or optionally, the proportion is within a range defined by any two of the foregoing values (e.g., 0.01% -5%, 0.1% -3% or 0.5% -2%, etc.). In some embodiments, up to 1% of the functionally defined biological sequences comprise functional sequences (e.g., sequences associated with, or determined or known to have, at least some of the desired functions in a relevant context). In some embodiments, 0.1% -1% of the functionally defined biological sequences comprise functional sequences (e.g., sequences associated with, or determined or known to have, at least some desired functions in a relevant context). In some embodiments, 0.5% -1.5% of the functionally defined biological sequences comprise functional sequences (e.g., sequences associated with, or determined or known to have, at least some of the desired functions in a relevant context).

In some embodiments, the biological dataset comprises one or more amino acid sequences of fixed length or a portion thereof of a heterologous gene effector disclosed in International publication No. WO 2023/004338, which is expressly incorporated herein by reference in its entirety, including but not limited to SEQ ID NOS: 16155-47350 of the above-mentioned publication.

Further provided herein are computer-implemented systems for performing the computer-implemented methods of the present disclosure. In some embodiments, a computer-implemented system is provided that includes a computing device including at least one processor and instructions executed by the at least one processor to provide an application including one or more software modules for performing any of the computer-implemented methods described herein. In one aspect, a computer-implemented system is provided, the system comprising a computing device comprising at least one processor and instructions for execution by the at least one processor to provide an application, the application comprising a software module configured to evaluate, by a computer, sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising a functional (or functionally determined) biological sequence having the fixed length. In some cases, the application further comprises a software module configured to replace, by a computer, one or more random residues in the sequence to generate the mutant sequence. In some cases, the application further comprises a software module configured to evaluate, by the computer, the mutation sequence based on the fitness function. In some cases, the application further includes a software module configured to collect, by the computer, the sequence of functionalities accepted by the fitness function.

Further provided herein are non-transitory computer-readable media having computer-readable instructions stored thereon, which, when executed by a processor, cause the processor to perform the computer-implemented methods described herein. In some cases, the computer readable instructions, when executed by the processor, cause the processor to evaluate a sequence of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising a functional (or functionally determined) biological sequence having the fixed length. In some cases, the computer readable instructions, when executed by the processor, cause the processor to replace one or more random residues in the sequence to generate the mutated sequence. In some cases, the computer readable instructions, when executed by the processor, cause the processor to evaluate the mutation sequence based on the fitness function. In some cases, computer readable instructions, when executed by a processor, cause the processor to collect a sequence of functionalities accepted by the fitness function.

Also provided are engineered gene effectors comprising one or more polypeptides produced by any computer-implemented method of the disclosure. In some embodiments, the engineered gene effector has an amino acid sequence that has, or has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to any one of the polypeptides produced by the computer-implemented methods of the present disclosure, or optionally, has a percent sequence identity within a range of any two of the foregoing values (e.g., 80% -100%, 85% -95%, 90% -98%, etc.). In some embodiments, an engineered gene effector (e.g., generated or produced by a computer-implemented method of the present disclosure) comprises a polypeptide having any one of the sequences listed in table 8. Also provided are engineered gene effectors comprising a polypeptide of 85 amino acids in length comprising any one of SEQ ID NOs 1452-2199, or a sequence at least 85% identical thereto. In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to any of SEQ ID NOS: 1452-2199, or optionally, having a percent sequence identity to any of any two of the foregoing values (e.g., 80% -100%, 85% -95%, 90% -98%, etc.). In some embodiments, the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and effectively targets a site of the target gene, optionally, wherein the target gene is endogenous to the cell. The target gene may be any suitable target gene described herein.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1495, or optionally, having a percentage of sequence identity to SEQ ID NO 1495 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1495.

In some embodiments, the polypeptide comprises an amino acid sequence that has, or has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1592, or optionally, has a percentage of sequence identity to SEQ ID NO 1592 that is within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1592.

In some embodiments, the polypeptide comprises an amino acid sequence that has, or has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1595, or optionally, has a percentage of sequence identity to SEQ ID NO 1595 that is within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1595.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1634, or optionally, having a percentage of sequence identity to SEQ ID NO 1634 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1634.

In some embodiments, the polypeptide comprises an amino acid sequence that has, or has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID No. 1654, or optionally, has a percentage of sequence identity to SEQ ID No. 1654 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1654.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1665, or optionally, having a percentage of sequence identity to SEQ ID NO 1665 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO 1665.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1677, or optionally, having a percentage of sequence identity to SEQ ID NO 1677 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO. 1677.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID No. 1686, or, optionally, a percentage of sequence identity of the amino acid sequence to SEQ ID No. 1686 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO 1686.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID No. 1689, or, optionally, having a percentage of sequence identity to SEQ ID No. 1689 within a range of any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO 1689.

In some embodiments, the polypeptide comprises an amino acid sequence having, or having at least about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to SEQ ID NO 1716, or optionally, having a percentage of sequence identity to SEQ ID NO 1716 within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95% or 90% -98%, etc.). In some embodiments, the polypeptide comprises the amino acid sequence of SEQ ID NO 1716.

TABLE 8 amino acid sequences of engineered gene effectors encoded by functional biological sequences generated using computer-implemented methods

SEQ ID NO	Amino acid sequence
		1452	ICPSTATPGNSGSDALDEFELDMEWGMLLDDFDLDMLDLPAEEKHCMDTCTDFAALDGDCLFDDMPDHSPSPDDDCLFENFPPLQ
1453	PPFPATQVSGDTPEINNDIDQGDGVNFDCDMLESDAHDDFWLDMLGAMQQPEFDLADLDLVHGGWVEGFNWMNGDDMPEPGPGAG
		1454	AIPDVDQFNSFEDFFQDMWDTSLPIDFDTDEFNTATTDFDDFLKLLGDNQAGIPSTPEGAEMQFHVHTGCPPVASQVSSHDTIKL
1455	PDDPDEPVSPNNLATTLMYHQLGTDGNVSGGGPCGDSPLDLTLFSLHDDLSAEWPEFDPATLDMADFEFDQWKWDDLGVSDLDDV
		1456	DQPPSEEGFPPHWKEPTEPSDQGYDIPSLDEFLDDMGLVSPMTNMMSGLMGYNDLGTIDQSELAELCMLDIEQYTSDAGEGGLWF
1457	SPDSDWPHFSGRSDPIPDDVPVGWELPDLNFYIPDFALDDFDLDMLGASFACDEQNDMLHNPEQEETPLQTPRPTEWFYGAYNID
		1458	GWHNEDMPDYTHMLLNSMPAHETQLAWFPPSPDTWINTNPWTDMDLPDLDINDASIQELLNLEVPVQDPDGWDSISPGFSSMEPE
1459	TPGETEYGPRLTPSPMPTDLGPDTFNFGFDMFAGLDTSPEEPIPSLASDLDDYLHTVDHQEGCCPDALDDVSYILEDLFDFMDRN
		1460	GQSEPSMSCDFFNPFTMGAEPEYSSNDPPRFSFAPAKFTTPECFQELLYDDLDLNPSTDGEDVIMAMADALDDFDLDAWPEWPSP
1461	HAQRNASMYTGFDCDSDIGPIPDCFDTSPFMDTCSDGWCHTLPHDTEDDIWMQLDFPVFLGDAPIEGPELTPDFISLLDDAIDQW
		1462	AHPSQPPEEYWDDFLLDMLMSDDHWIGTQYPELMHALDDFDLDMLGSDTYDMSCLTTEDFQAGGSFGGLSALCGSEGPDSPGHGD
1463	SSPASFEIPILETPDYALPSDGPGVNDDEDIIEMLLASAPPTGLVLSDQLEGQPPSGSCDEAGSLSMPHTYWGNMFEDMFGDSMT
		1464	VGTLPSDSENFPRSDTPPQFGMSDDNLCEMTPSDTGDSFDLHLNLPDDQAALHALLQEAGPLDWDELVPLDDFDMNFTLNGMYDQ
1465	GQMDDSNTDITDDLLAPHLVSMMDEWLGDCDHIEGSVLDLFNDHEQTLPDLGILEELLIGDATAPEYQAGQCGNIMTVDDPPHLQ
		1466	PPVGSMPDYPHELNHRAWELLFGEEAHNGDNFPSHPSPELVHPSMLESASWDDFDQDMLKFMGYDDLWSGPVQSQILDDLHLFED
1467	IGECQLPSFDGFPALQPPVEAEFVFDFPEPSEGGEEMCYHDLPDYDVFGFEASTPTNTPRLAPGDNPEWEDYDSLFPDHFGFGWD
		1468	SSENPSNLMSPGLDETGGSSEPYRDHPFPEWDTFIDDLMLDDDLPDPFTWTPGVEDTGDCTDQPLSPLWVDTYFTWDWPGENYAC
1469	CEAPMEQFDPGCNIALVAGPLDGLGEYDFNDLDLNWFEGYHLTDHSCEQLIDFMDPDPTDFDWDDLADPSFGTSPLTPDPPIYPA
		1470	SGGSSPSPQYGSPEDSLLDLVDHEEHVCPSDDWLDDFNDLFSDTAELWIPTELNNWEPYGRASPSHGSSPKEASQDDPIGWIPDM
1471	GHGDELMQSPDPRAQMPFLFADPLGTPALGDCAVPDALSDFNLDTLGSGNEHMFIWDMNDVDAFDHMLDDMAKDMYDCEQLGLDI
		1472	AAFSDLLSPEELWSDTHFDAEFTEDWWDEINCLENPAAPGGAAMDSGSGLDDCLPPVDHLEINWPSPLQDEIQEFLDLGDDCDLS
1473	PDAAQSVEDDNMTLGGEWFTGWGYDFFAGFDHIEGALLDDPPTVEYDLDINELDSILLALSAMDMPRPKEDAAECGSTQSGATTK
		1474	LCGSELSLDSLDALEPSGVSMPSNSDECALWDPLYDLPDNFDWLEEIDRSLGIPPLPPTSMGPDLCGFIWSLEHENTTQDWGHHE
1475	QCTGIDEMSTWDDVMTHEYDTQTQFDFPEPLEGSVSPFRPNLGPLQYQELMAEPAEDPSWSWPYDQFDLDALGLDALDVCWYPPN
		1476	DLTQYEVPSCSDQFIGEHFAWPVPPDLEFDQPFEFDQMEYFPAGDTDATNAGDDWPPDLSGIEEIFTIVPEDHVDMFAGLDMLFS
1477	GGGGSHPDEDLNIATDGSIVHPLCVHDELDDLTYPGALDTYDGDQLGIFDLFDFDLDMLGGTIPNTADPVISYLLQQVTHDTNDI
		1478	IDATRDLIGPLDEIASDGWDTSYPIDFDFDQFNTETTDFDTLHELYDLDYTAPEWPNEEAVSGSDPIACLPDPSVGIIVDTQEWQ
1479	ANDNAASAEIIYWDTLSPCHKWLPDDFDLNMLPEDMLDEFDCDLLVSDAIHQFDLEMLGYGQGGPEMRHGLNIYSDDYVIIPSGE
		1480	TTTASGGSSAGPPMDLDNLGSLDLDFFDLDYQHEPAHPFFDLDMHGLDDLYDCLAMYEDLCKADEGDCNDAGFMDPMGGSLGSNS
1481	DNPPHSHVDPHQGCFLDTALPTIVGCQTIEPTVCSDILDLFDPYALGSEALDTDNLDTLGIDDLLRECCAGVASWQQEPEPPQCD
		1482	LSEPEGSPGTSLDTWPVNYVTWDQVFALQGTPAEALPHDVNMTDDLDVDQGLMEMLMTDESELETLLDCLLPVETQLPPAYGPQD
1483	STGAPEGSLDENFNMIPGPLLPLPMQEDPWQLLPDMGTYPSGDLLGDLPDLGELSELLCPEVSMAIESQHDFFGEGSELELFASG
		1484	PDVDNLTGCDFDTLLNHLPGIMDQNIHDLMEPSTQPNQGGASASLLSDGSQLDFDSLYEWDADASAGEWQHLEAEAWEFVCHTFS
1485	ECPGGDDNIPAPEGYPLNNENDDCLDNHLMMDYSNIDDLLTLCGVDLSDIPSPGPPVGMSFGPFDEWFDDIDGGQNSRTAGSLLG
		1486	DTPMHSEMQAQHEGEMDLFHDVGWEWPDLGFAWYEDALDPFDWKILGADALYDADILASPTPASDYNLLDEHGGFMDDDFYFDFN
1487	CDSMDNDKNSETMDGLGTLPVVCDFDLDYNFDSSQLQEFLGNAGPDFDALWDMLDTYMSEDDRALFTEGAGPVCEEYGQPASWHC
		1488	HLCLDCTIVETLGSGDLMLEQHPSLECPQHSGESHNLTFPATDLLAQDALDHFDLDMTMWLEEWSFNIDSADWDLAGMESGGSGI
1489	VGALLGLDSYPKTTPSLMDLSVCEYDDPDGSLGTKQVNDLDGLDMLGSRLCDWMDLDNTAFDNLMPAEGAMPDEGGDIDWFMMDL
		1490	TENNLSPMANWWDEQGLMDNDQYSDWPDLQELPPDLDLMTEALDLGSPLTPELHEILDMFGIDECGNHDSAAGDGGVVYMTKGCQ
1491	ATAQDDEAPLQVHLDEVIIPNHEPCADDSPAQEWDNWFDMLEWTDAYNHAFSSMPSFPWFEDVALWSDCNIDTVEQPDEPPCFDI
		1492	QIYRFTADCTPIQCDEGQYELDFDWDFDLLEWCDPTHMTPNDEWTPEPPQGCSSSVHGFTSEFEEEYLMDQWEEFMPTPPPHHDL
1493	GWEISGGAGDADGDPHPGQAFSGPMDFDAALPNIPTFDFDDFPLFADLESFMEPLGQEGLDCLGYDASLMKAVQENLGDLTQSSW
		1494	AILENWVIPDSSSAVVCGDFSTDELQPTHVMHAWEEPPHQMDISLEEFDNFWQEQAQHDFDAEMDEWLSSEILSIFNDAPPLGTF
1495	PLCPLGAEPQHGVGWEPCPLSCEPQHAAPPIHCYLWPDNADFLDNGAALDEVPFCEIDIFDGDEFPEIMDLGVNWLEEWDPFSES
		1496	GHADNPAGSSLLPSPVEPDPTQQDLLAPWSLPDLDGFNPSLWFDMESISDSETQLGDHLDVDVYALLETMWNLPDPDEIPELPKD
1497	ECEICMALDSLDEMFEQWHYVDRELIQGPSNEVIAPLITLDLMSEATYPAPGVWGTTLGMTGETVDDIFDWNIEDYLEIDFSELM
		1498	TYAIWPEPPPLDLHLEDLCACLEQEANGEDTPFESDAAATFDAMLDFDAALEDCDTGMADSPASLNFSLDMGDSDYFSNWMTMML
1499	APPVFDDICETLDEAEPQHGYPDHTDGLVHQVLEPELEAFDLGMLGDDSLDNFDLTHMWAMLEEEAWGESPAAECNQSVQEGQGV
		1500	TEAEEEASTPTEPPGSEFTDIMCDWLPCEGDTPPSDALDGTLLDILGQALDPDPWPHMNGSIAHLEFDLDMGYWCSPVQHQPEMP
1501	CSHDRNHSTFEMFPLSESTWDVICPDAHDACLPTTTEMLPEDLYLDSPLEPELMEILDDFLGAECQLNDGFIADFLLGAGDENEP
		1502	CDVTSEYAYNQLAEEHLIPMEPHRPLCTSGPLSDTFAMDDFDSPDLNDQALDDVPALWDFFDALNNAPNAMPLLDMLTDFDLHNA
1503	FDQMWLYSFNSIMMANHEWDNQPSHDGGPNTPPPDHETMIPDLNLDWLDTPEEPDDVDMFLNDWGLVSQMLDLQDCVDWPMPYDG
		1504	EHTEFMATGMDQGESNDYCWMYDLACECMADSGSPNISPSLTLSEYEEFCRLLPDMDTVDVGGPWAAQEPLFMHEIYESDEPQDL
1505	LGDFDLDSMLLPAVEPPCVAEPAEPPESELSSIYRPADWLAQADWHMNTTEDALSSDVNQFLSELFEPDNWENWVGENINYGLDE
		1506	QDMDDAEAASTGEFPVTDWLEGPLPRQHGIASGIEGFGSTGPSNLDEDSWLDYLPMVDQILSDEYLPIADVFNELDDLLDFSCTM
1507	VDWPDEGTEFEHTDYFQNYVLPDVDIDDLLALLGDASPSKEQMGESTVPRTDMTLWGYLSDGAMPEENWKDGFCDWEMGGGEGTR
		1508	AREAIGIKTPDGAGAMACAEVFGSELFPTGDLGDNDALDDFDLDDLLNDEFVMPDMLPDILDTQFLTTLQPHSFDFMDGHGHGHL
1509	NEAFCSTICETTGEAWIDPDPRGPQPWEYAFEELCASPMFDTSFDDLIATPWYLEGLQPDHLLSIDPVCSEILGDTEENKTMQHE
		1510	FDDQSMLGLLDNFTPECLSSPSEQQDLCPEEDPYAFNPAGSISGDIIDELMLCEIRMDPWSYHTPADEPWWHPHCDLPQPSYEMP
1511	QPYVYPSVNTNISPSEPAHEPNENEWLGWDNSLAWNVGSLNDEFWLDLLTAGQPCFELPDVGGEPMNTGLADLMEFWAASEESMS
		1512	AQAAPAAVEQLDDTISLLLQFGDDFDLYKGGLPAGGPWHGGPYYSTDSGGDDFDLDCIEPWVMEDSELSDVGLLDTDIADLILQG
1513	KTPVTVDTVSTCYPLERCNTVAELFDAPMAQDYTQWDNALELCQELFLDWDTEFNLHHAFEDDIMAGFDMLDQFEGTAEFLPTSP
		1514	PWVCPRPMGDSDAVAPEIDTVGEWHFEIPDVDIINSPPVLHDLLGESSTLPDWALPWMDDQFCELDLMGQLGGPPAEFDEHSVPY
1515	HTPRGSMQFSTFCELEAVDFVCPASGETPCLHDEEELLDWKDFDDLPQLAPMMDVGDLDSIGPGWSWLDSYTSPIEEFLGCFDAE
		1516	EGGPAWFTQPPSQDQGLPCCTCSAPECMIMPVAEWECLSQPIADFEQFTQAYLDNLNRDMSGEDNMSEQWCWDFMNSFDDTAWDT
1517	VMQMDVEATGCCDTTDTNENWLAGCEWPLPEPYAHQDMSSLDNLLHSDLESIDTIEMWAGGDTLALLETFMETMEMPHDYHDGPY
		1518	LDEKCSMGFSDFIPTCPLNPMCGFMEWSSEPTDVEFDIPPTWLDDLTSLDVSDVVGIFDDLAFPPPAQTPEDQAHYSAGGGGTQG
1519	SPLRAPDIEFALPAWEDGLDLDWCFDATFDDFNFDTTVEDAFLDIFNWMEGPCNILSELGQGEPPPTRCQPEQGEDQYETPVSYP
		1520	WSYPCGIEWPGPYSSSGRNSSQTQPRSDMTDLDLDNFLDLLKTDVESIDLGDFNDDLLGDSDTLDLNQYLFPVDEEDDTCMQPDV
1521	PGLPDHVTPCPDDEFNLYDNTQHPFDMPEPELCFEEMPPLDLFEILEISLTADINCPAVDTNSLEAFDLEDIQQTDNNPFTYFNE
		1522	MATNSPVDSIRDETSPNKLEGSHIDPGDLDEFLDHMDLDDLWKTLWKDDQIMSHNGSINSCLENDMDVLFMHCGDFEIPLEHEEW
1523	GTRVNSQPITTEAMDSVAQSQAHELYCTPSEPFDTPCLPMYSLDSDDSLMGPTSDEAIGALLDIESFFDSILGGPSLGTTDDDPM
		1524	KQYPQGVHGAIPQDPDAPAWPEFEDAEMFFACEACDLSPPETNTEDPELQPHSWEPLLAYEPSFISETIDTMWGCWDNWPWPDLA
1525	DWWEHFCPTTDWGDPLQGELYTPWSDVPLDQIQPIEPTAGFSDADLFNMLFHSDPSSQFDISHEDWLVNEGGSMLPTTPQESENV
		1526	AEPSGSGMPTSQGWITGPQTPHLIDWITHDDIPGWPTDPSKDMSTLELDSSKFSLLDMISDEWLTQGSFEWPTDGEGMTGQGGGE
1527	TAEVIPYVDCPEASANAPTGANALEQPDLYDLASGSTWPLYASDMEMSDFLGDFCLDMLGMHDDIMWHNTLLDMDVLDDWDLSEP
		1528	QEQVDLEGFALEQPIDDSNLEMNSPDGPVPQSAPRISEIGSNWFDIIDELGSPDMFDWLWCPPTPWDDICFTLDDLITDPQFEDH
1529	PPSDTDQWEFASLDFFDYDPEGPGGDGGGEPTHSTLLGMWSDLHLGDSNLTESMPSPELPGPVGALLETWDISTMAEWLDIPIDG
		1530	AQTEEIQTDCAVGSIPQLTISPLDWHLDMDPHQPMFSGSLSQSHPTEIDDLGFLPEDLDNLAADVDAFTEIQNGMSLAEYYLWME
1531	DPSLGCLQPASLPIDPASELINPSPSRDSNYEPENHGSDLSPMVIQEMPDLGGLWMNASELAMDWREFTACDSDLWDLLGDGSDL
		1532	GAAYQDDTLSYLSELVEQQLQQYHMEQWGSLWDSPATGHSTMSSDLELPDLGDLTELLCPPADPQLSSHFTGLSNWIQQVDGCNE
1533	GGAMTTRDDTSAISMPCFGGSQHAGDHPPSETPNEALADFDLHLLGDSDFAGVNFDWMNKGCDVADFFEICDAAFGDIRGFPEQS
		1534	ALNVNAIEGSEHGDMPLMSELEHHVTHCPEWWYNDEAADFLQWFEETTNEYDNILGDHEFDPFQEDYNMPVCWPNPDFQGDINSP
1535	ALQQHTTPVPSHSEIADIMQDWPTGLIQEDLTISPPPPETQAFWQTLINEFFNNTAMWGEYGDHNPDEWAPCGSGGDTDQNPITQ
		1536	VNPYFSYEDITPMTGFAPTQTCNDELPELFLEPQVAESFDEAELEMPSPHMNDFDLDMLLPDEWPPFDDWLTELMHFMDVQHAHL
1537	MDPDNMLFGVEAWDHCFMGVEHMDNVQEFAETLGFNDMDFDDMPNDIELLNCLGSPDSPAHTSLWCPGYMEQTHDPEPTSTDHSG
		1538	YNGCHPGSSNWFGDQMYTQWEEGMDLDDILGSIGEITPPTSHSLDFFTDFFALSPMNSETDLEWADFFEGQEWHGQDGCTHTEWE
1539	ELGLYGELPHRAIGSELEEYPCVWSGQTPNTQHKDANSLMSCQDFQDILDAGFEDFTQGVDFDDFTYSVLDDAWLDQGGATNQWM
		1540	PPDSMDCIGSPGVGVAGPSSPHSESQDYQGWETSTHEYNLEDDLQLLDLETYSPGSPLTEIEPDMLARNWFGECLFGDWVEWPPE
1541	YNANHMEPPTPPTTFFTDNLLSNEDWGCWNGPNDSAVNELFSVWGPQAAPPEQSPSFIGPSFDELMDWSYGWPCGGEWSLNWEDW
		1542	EMPEADQQSGSPWSNLLFEEVGHEPDRSPADLDQDMFSGGVTLGLNWYDLNDLMDFDCMDFNDLMNGEGETFPTLEGFLTGICSP
1543	ATGRDCAEFQCDSPGSVSTSNWLQLVEDMLDPDPEGLGDFDWREILEPDCVMELDDPAFASLDMASQEMPMPGSVGFHDDLGQQE
		1544	PSSNYDGTGHSIITINPDLDDCQSQDEPGWLWDTMTHAESQEPIPFSSVEDVFRPFPCDDLGQFQEDFYTFPGDFFDYIAWGEMQ
1545	LPEADDDFCPSESELFSQIMSLWDDLQYDDPGADLCQCILDDCIIDNDIFVNAFITSGGDSPSHQSGGRFNHNDSPQAFNPCESH
		1546	PGPEPEDVGMGALWGETSGLGDSEQGDVFSDLDLDFWIGSLACDMDESLAMLDSVGHKLCSIYPNLPPSPLSLPDAWGQGMDQEM
1547	NWFDELWAEIMDDELPNLHDVRWPQGDYQSIEAQEPLSDDCFQEMLCDNALMGNDGLPDDANLLTWLESEWSASGSTDEWPAQPR
		1548	NPNDDDYNPGDDNISWDPSDDDTMHTSPTSPVNPFDAPLGYDFNLDDFMFAQDFTDWPVFEEWMGHFEMPEWCFDPMYEDISFQM
1549	ADMADFSGMECVDMFTEVELSPDVFDFELPEYTTQEMSVSEDLFLDADTFGTPQPAPAQIPGDPYIQASVRNLAAWMLEDPWDFV
		1550	AVPVTQEFPCQAYDMLPEQHVEAMDSHDSTLPPGQTGSMTCPMLALDDLMIDDILPGLRLSPNLCDPFECEFGTSFGFPVTPLDQ
1551	TNIPGKHINNWADDPLWDELLDMVPTHPCWFPMADHLEGANLFDVTMDDLEHPDLGDLGFNIFWNDALDSNHGEGQGQNESRVND
		1552	SFAATNMASPCSLDSTSCSHPERGHEPMPAWLNLDMFSMTEDLTTRSPLTWDLDNLLDTFDKDPWGNDAMNDVLGGDGCYTEAPQ
1553	YPPVPSTTESATCTPHDGWPTETPEDFNFDEFNTDYTGFDDFLMLLCDNSNGIQSPWEGAQMPEFVDSDPVCDAPEVEGNGWIWL
		1554	CEAHHCSHEGDHSVGMPHMGELHDAYAEEGVNLPNSPVIDSVDCDSASSYLDLGSSQWLKEDYLDDNLLAPFAWDTIWDFEVPDW
1555	EPTDLYDVPGGLPCDIDAEWNISGCLGDSDLESSGLFSGSTGSPMDWNVDMKDFDMDMLIPPCFPPADSDDGQEPPDLGYPLFLL
		1556	GWGNLDATTSVWYDLPSEYWSCPDFEDVSWYCDIPLESPDLVDASLFDLFNSLDDPYAIANPQIDPESSEPFNTDIPGAEYHMLG
1557	QLPEWQLTADQDPLLELPDAAQYDLDALCTRPLKSDDDTLGSAWYNFSDFQSIWGEVSGMWDAIPSSDYYEILDDSLMTLLGDDD
		1558	LDPGLVPMGDIQALQQDRALEHARGAGQVGQPFQSLYNTPDSLHDLWYGDPATVEPWDTYDPCDFFYSLLENEPEIPHSQNTPHN
1559	LAWTEHPLHDFCSIHNDGFDTSEPIDWDFDEFNDCFTDFDDFLKLLGDNSPSKGGGGGGGGEPLEAFDLFIPESNGDDVTVLDAY
		1560	TETDGVPGPAIMTLELHPADASYATDALPPPFDLDMLGSDADDNFILDMLSGANLPCLPCLDQQPWMDQCIDFDDFDKFDDFISK
1561	ASDPPIPYLPGAENRCPAFLPNTFPDSGFTEFNPLDLNNLQIEDIHPWEEGLGNILSELEEWPKHFDTFECDESMDPMWCPGGGI
		1562	LDNHEGADEPSDEFPLEGFAHHINDYLNYVYEKECPTGPSSASLPDLYDLEFDMPPLDGMPFWPEVNFTSVLGPTAESANPPSSD
1563	CCNMSQEPIWEDCIWQEARATVHFVAPQQDALSNANLWPDTPYDTEQISFPSLGDTPWDWFEPFPEFLDTTATPPLDIPQFTEPL
		1564	GGGGSCIDTEGFPDWLDDAMGQISELPPPSNLESSAPTALVEQMGMELPCLSDLSELLCEHDEFMAGSAQLDDLDLLGQGEFKYP
1565	DPFPDMSDPLLDMWICNPDAICHESLSTNQQQGQNFPDPEDNPHDMPFLEFVLNELDFYPICEDVKMQEALYLDDPVANEKNFDH
		1566	RPGSSNGAVAWPPAAEAPMENVPPHLCTPDELDLDFFSGNLGLALDSQLLSEDVLNLNTFLNMEPEDLGFVLDDAAGVCDLSYIL
1567	GSLPDVADLEDHEWGGFLSDWEYTGDCPKGLEAWDEKSLGDLFDQYVDGCENDFIEDDGSGMGLVDLLLQMDASSGEDGSMLGGS
		1568	ADALDTSGPVENWLNWLPDDACYYPDEPWPPPLESFAVEPTIKEILEESLPADGFEPLCLTPDAEAFDADLTMEFGWLPNMVEGE
1569	EEEATALLWGMSPMLLNPDGADTGPGGPPPIQDLDDFNLSLGWLDEQKAVPILEVLCSEDPCWEESAAPGWTLDDFLLNAHGPLD
		1570	IENATWDACECYDCDFLDNLWPYEDSFQWTPTPDVSHNFDNPRDSPIFEELFAGPTFFGDMLCRDLEDLDEYNQEYELPPPHIDL
1571	AVGSSDSWGLLDMPYQLDVMDHARLVESGALLDLDGFDDFDLTLPTDRDAADDMLSDLIDFKGQQALPPPPMDTYALGEDGDPCF
		1572	CDIDSSLWAFEHFLEDDQFATCSNMPVDPLLDMTGDEFSGGDLFDWFDWDIAPCIHPMTYDQPDGPHHPYEWVFPEELTPPWSGP
1573	VGIVPTWPLENEAQPCEPMAIHESQACPADSTAYNPTPSEWDFDTAINWDVWNYSSLLDFSDENMWGSLYDWDPAPCATCMGDFS
		1574	PDQTAQDFWLANDFDFDFFNIEYTDLDWWQWLSPPAGPTDEQQSNEYMASDYFMDLPFSPLSADDYTWATAHYPFNLGDANEQEG
1575	CHDNVCPGPMVEEPPKENLPEHDGLDNLLGMDYYNIDTLLTQPLTDLDPPLCPGAFGDTWQVEEQASEGGLGDWGDFSDIQWTLG
		1576	DGHVDTDAEPPMENWIPMLFDTWWEQCHQLPPNHEDLTTYDPGFNLLDQVLEDDICAQMFDMPWGPEARPSDQFMLMGWPMQETD
1577	EFRHTEPDPESEAQSWDEATNANEDWPLWELTPWTPSPEFTFLMGEDYDLEDLEVHLFSGPFQDIDFMHSEDLLAGEDASSPLNE
		1578	FEHVPHYLHSGAPRVDMDVLPTLCYDASPGEVHTYALDDFDLNALDFSALWDYDDPAPMDPMDTYILAPFCGDGGSPSWPIPFEG
1579	DATWHSLTTIGNDNEGPCNEWDDGLDNLLGMDESDFFDTITQEPRDLDIWLPYIHGVMMPQPTEGEGPGEDPCPGYLDIPLSESQ
		1580	GGGTDALVDLLSDYIPPLAPSLGNAEPLSEPPTWVTEMLLENMLWLSAATPDQDDPGNIGGYTEEMHGDSICMWSELGFDGGQGT
1581	AQMDHACFWETNGFDTWTDTGADDLPQVSWGSIPATPGATPDGPSHAGILDDILPMYDHLDGCLQDWPSPMEPMDVWAHLWYQLE
		1582	DDPFNSYAPYEWTVDELPDHPGGQSFATQPHPVLSGETDAMDDDPWSPLMGDVDLFGLLTCSPTPADTPQEALDFLEYPCDLGDG
1583	ANKGHTTHLGESHSNDKDAPAVPGLTYPWCTMHSQAGSPSPDIWDELMSPVSLGDGLLSNPIGDDTNHMCWDMLFDFDSYITWDS
		1584	AGVCHSDTQISGDGPGIMDVGPDASMQHCEQSPQGPVAGDWEQPTAEFNRMEQEWTGEMHAELMDFLLAWIQCDDLGATDMPWVG
1585	WHNYDEAMPQSWTDPDLKTVLTTLDFWDLSVESFFAPSMDEQTQAPPTDESLGTTGNTPGEDVGMFPRTELWDFLLDDMGEPTSP
		1586	THGPEHFDTVASGFAIDDFDMGMLFDSAPCWWDCHALGSDQYDLFDLNLGDPSPDAAMYDFAWDTFCLDHEAGMAYQDPAGTDQT
1587	SADTEPVPAEPGSQCPKWPGEWLMDDWLDVSAFPDFDLDMLGDGLLMETVSEPDPYAPSKELDDMLDNFGNHFMNALRADDWMYG
		1588	TQIPPVEMPGMGFDCSLDDDLPPLGSLSPDESDWLFGGPHSTHPWWDCGDLCPDYMDPTTGGWGSTDGCADLEQLLQGSMWLENE
1589	PPELLEGMHRTNDNTQTQHDYCGFGYDTSAFDDLFAPDGDWAGTLFEWLDSSHASIQELEDCVPWPYPPFTGNSETDLEMEPIWP
		1590	GGSDSQAEDHGELPQLGYAGSIYDVDDRDLAIIGLNPASFHLCDEFSESNSPAPADCLDPGHEWAEQFLDVWDFVDDMFDFSSGM
1591	AIHVAPTGMGDMQEWLYAECQAEEAPWRPVNCLEMALDDFDLDQLGMDFLWDVDLDPAAHSMLPSIANICVSDPFQGGAQGMDGY
		1592	PGPMSFVEEHDNLPMLHLGIPMDNVVTPPQMGEDHEWPAPNLTEYSEQILEQIASNNTLFDEQFSELLETWDLYDNSEPLGDPFV
1593	DDIVPPHTPMTFCPYWMPWEDSSGPGCVSDQCIIGDPLPVAAMQDGIDEDLSFLGMMYDEDWECPPFCVNLLSSMDQDSLPPWDM
		1594	PAPQPAYFAKMIDGQLNEDPLWDFMDFDLDIPWDSFFHGAASPIDLEDYSPPPHDQDWQSLDASLSMEGVSQLDDFDLQDMYTVV
1595	GLIDTTVDIPGSPQIDEMFYEHNFEPEHVSNWGWQPGQVLQQLLGESSNLPSLEVHDAGQDLPTLMEDLGYLGLLPPLEYDEDFC
		1596	GQGGTGIPMTFGNMSQTDLSIGGANDHDHTEPPSTANPGCWMSTWFPDVDSILQSDWPLVDMFQPVPDDEVHDPSLQTHEFDEWW
1597	GPTSDPGPKSEYLDVFDLFDLDMLGSDDEEGADWDMQAPKVNEDLSLDMLATSEDDCLPPVQDPSDDLCQYNNWMGLGSPMGSLS
		1598	GGGAERFTQPETPDGPYMDLASWLQGLGQEFPLAPPMPLLPGLLEEWIDIEIPDTSGSGDNMWEEVHFCSPPLDNSFDLWGPPLD
1599	GGGDLGPPISFTPTLEEIEDYTTNFNVPIDDHPDAFLPTVWDLAAVWEDIDLITGPEEELSWEPYPWQIWGDGGGESSSSPPGFK
		1600	TDPVVPCASGPQNQCSTPTHQCESGHIEDDSQCMDMFDGWLEMDIINELESALRDADWLDDEWTLPVIPAGLDDLCGLGDPGDFQ
1601	EPDFDGFIEHALNFLNSMDTNLAADYEHPQIEPDTNAQLTAATQPAFHAILPDFYWDAPGECFSDFDWLMSITEHNNFESDGMVN
		1602	AESSNTTPGPLAGSTFIFDSYCIGWPQYMPNVPPEDLRESQFPQYSEEFQDLDELICDQDLGAEPWTWPWSPTYDALLSDIREDW
1603	YGGQTNTTTQAQIQELGFPMEPQRPPVAENISLDSGNQLVHYTLNSLGLDDPWGYNEGARDEPIHYYLDWGAYEMDLDDFLDWSG
		1604	HYDMSAEEPMEIIPNFDKEFDELFPCFPFHEGDFAIDVALDACQDLFWLDPPDGPWQPPLASQEWLQEDFAWPHGARSPGQVTQE
1605	LDTGEQQPPTQESLQGWFNPPPWTNQIPFFDALDDFDLDMLSNADSPGPSFIDVHPLWDALPWPMCKPPVGVGQDVPWGDFPDFL
		1606	QPAQTYQETDKQFDNVGPGIRPRAGALQPGPEAITTEMLCMEDMTQLSLGDYAELCLPEGDSSDMAELSMLMDWWLSGDADNTFG
1607	PQLSEYDGPLAASQDSAVSIPDMVLLPATYDEQWNTDLSFDYNDLQELDDLGDLCDLHFQLLPPMDDTEGELWRCFETEFGMSMG
		1608	PDDCCWGDDIPFDVSQVPSLEATTECLGLSQGDFEGLLDLPDPIALPDESGPVADWMSFLNGCADLEPLHTGGMGQSSNLEDPYA
1609	ELGASTPEMDPVSANHAADVMQERSIPDNTCNMCPQADSFLRQWLGDLADPFLEEFAQSFNPDDWLPQEAWDWHLCPGQYGENNG
		1610	GGSEPLNEINENWLNFPLCAEFSTSDEHMLLDPLYALDDFDLTLMGIDDLAPTYPAISDTHRIENTNHLYHQPQTPCHICGLGWC
1611	SVFYDLTPCMIMMMAMSLRMEFGMDFETETWWCPEQIKPPPWTLRPLNSSICGYHCHADANWYKPHIGHFDYETSSQIWMDTEKF
		1612	EDPWACDLEWLMEFINADAWGHYVDLATLDEMLDPGMLDDLWLDKWAVAASTDVVGHIDRPADPGSSQMGMHDGCMHNSANDWEQ
1613	DDWASSVLECVLSDAEDCTHGAPYSQCETQSHWAVGNHLAPPDMLECIIEEAPPLWAPMCSGGDEDLWGKALFGEWDFNNDNSST
		1614	AFSGADWDNLDEFLCTCHFNEGRDVADHAQADPLPEISEPTSTLVPLQFNMQEDNANPPPIYTFNAPDLMAFDFDLDDWICEQPL
1615	DLMVYELGFPPEDDTPAPPMSGPETGPTPSNMDMEFEIPPISLYSDWDELMSAEVNDLLRLSPPSEQPTVDLYQESAPQYSPVSH
		1616	PPRDGSDGEDINLLMENMEECMDWSTPLRFPNSWDVDEMDLPLQLDSYDPEGFDITPYPEAFASWEEEPPDSNGWDPQFHVWYPS
1617	IHPDAIDDWNQEETWNNVQPCSLEYDFDFDEFNTETTDFDDFLSLLLDNSPSKCHKPPELCGVFEIPENWRHGGYKAEGVDIPFD
		1618	SQARDGGAESDMMDAFDIIDLDWLGLLDDCTAPESHNMMFPDDDALMAEAGKVAANGATPHGEPYEMGPMMTLDVVLGSLDGLFA
1619	LEFLDPTMHMCEYGDQPLLEIVLDDLPPHDIGTFSSWEDFVQDFFDSLGPLDDLGMSIDEPSNWISQSNSEETQNEDTEDPLMSF
		1620	PIVGPMCSAFDCFCDAIYEMTFDDPATNHNSPARLPPMDESLLNPYECDWAEFLLEDTPCGCETMGWTCDNMLAHQENQPNQHDP
1621	AYAGLPIVSDEPGMDCIVPLSLAVRDTPEMMWSPPPPAYTAAANDSEIALMDQLPAMDEGLADEPLMDLDVVMWLDDLGFGPWEL
		1622	ETTCLPINPHDGDSVEETVTEILEPILSVGECVTLPPAPTTLSKDGTHEFLEDWGWPGIESIPPEWDDYNFVWSDVDQTLDFGYP
1623	MEYTSPWNPAQWLETNVTLDDMWVRFPAHDEILEDFHLHMFADDNFEGDLFQDLLDVPSELWTWLDMEEETTIPLPWSPPESGSS
		1624	DCELYEGFPPYPAGFNVVPPEELTIDNDFDEFFASATEFDDFSFDHALMTAGATQDSSEKMCRDFQDIMEELDILDPEWTCIPFM
1625	PVPGFDMSPEQHGMEFPTTDFDFEWSEDTLWGWVTTPTGSETSFWSQPDCLFDFWSLCGQPNPETMPELPDHAVSDPQQESNDMD
		1626	AQEPADTPNHAFLPETSDLLPLMPDPWFPAWAPGSSPLMSLEQLMESWDDLELMDADFATSTGMHMSPSESGPSEAKNGEHGATT
1627	MNEGDREDPDEFAQIVGGSLDNTLDVDLFQHYIQSLLWPGNGDPLDPTPPTESPLFPPMYEPWVQYDFQPFSEYDAPELEGNFDP
		1628	QAAPLPQIPFLENLDQPEAPQGLPLGAFPSMAPSTMEDACDYTSEGSGPNLCDLSELLGGPFWEADDEKEGMFEDFLPLHLGSTG
1629	IYKPQETDPTQESYIFYNQDTSSWTEPFIDGFIPQDSNAHDLGGFMLDMMPALTSDMSRDEWEFPIWLDPLAPQNMHHEWEFFDW
		1630	CQNDIASQFNLMDNVTLWNEDPPHSAQALWGSPMNESLMTPEMFWELLCDDFAYAATPEDQTMENSYASPGDPLDWFAHLETWDG
1631	RPNDPPQQMQMPIDEQNEDPNVEDCACNPMHDDGLTVDFRFDLYGANLPNEDLVPPPLGLPLTDLEWNEEFLVDLVDFLGEGNLS
		1632	GIGGSGGGGSGGVDALDDFDLEYVFDMDLYCEASEMISMHDLFGSDVDGFETEANLEAFYGNFCYEPTNHAGDPIDPMCHGWTSQ
1633	TQWCMYPPDENQIQPMLANEEHGQPHDDSSADVARQPCVLKTAWEGAMCLDETLEDLDLADFDLAIDTWACDAPITYDFSVNSPW
		1634	DGPYMPTPQSSGTLSKLWADEDYDADQPMPPPHDDYIVWESVPPGLELPGLNDLWMDELFFDASDFDWPSAALDVDDFDKLWFEH
1635	MAENSAYWPQIEGLDEQCFFNDTALEGDGDLPALSFLSMPEGLPSDFPPTFNTPEILDTFLNAWPSFTWSDCLDDQPWPDTGDGE
		1636	DWSGFSPFDEYSDWFIGIAEDDHGSPQVDWDTPTAMPTYVAPHSPDTQFDMDTQQADNWPPHWNVDFDYMLHAYGMGTTFPQLED
1637	SNVMPLHDDFDITDISVECPGIHDTFLTTESGDTFWSAPEFSEFSTNILSLEDPYLDSLDLASPDLEPYWPGALIQQDEGMIDIV
		1638	YPQDVGEAEADSVIDFQLGDCSEHWGFALPGPPPAPQHALLSYNGQNQIELDELLRQMFDYPDVNLLEEPIPPNLCCNSLLDTDL
1639	QAAQEAAGPGTDAVEQWHEEPCDLGPFASLDDPNMGPGGVQMEPLWQTPGLDDDMEQWLGPIGTYCPEQADLMLGGLDEISISDW
		1640	ASMPPTPEAQGPQLFEDLAVYGQSDERALLDQLHTLLSNTDGEGPKTCTHALEFGRELTGMQSCQSDDGWWDPDIMLGLDFGQED
1641	ERTPGFPHTPLPEELDVDCWHEYVPEGFPQGHHAANQPFFHPLAEENYTDMDNCNMGLDFWGESLQHIEPEFWSISPWDFNDDEI
		1642	SQPQVTAPHDFSPQIMPLPWWAPSFEQIMGPEPHLDMTPPSEATFFTTTMGDPHDQENWYRELTLEVSNWASMNLDDLDAAFLDD
1643	GPDEDISDGQLIPGDPVAMIQPMDGTLEHWGLDLDTSMGSLSFDLHSPAEEDIFGAWGLGGGLDNPISTQDCDGTGPWGGPWQQQ
		1644	FSNSNLQIPDWAFETCNDNYVWEQSYFPDPLGLPSTLSALPGETLLEWEELVLTPEPAHSSFYWEGHTSGTGAGIGGGEGPVDQA
1645	YTPPHGQWMDLDYFFAGLPETETFFDFLEPQEASEEISISSQSIDELMGNDVFFAQPGCDPDVDPYPFNLDMGPVVSDHGGSSAQ
		1646	FDWHSQNAMSWEPGQNDNALFAPWPSNDNLPPPEYGLIYPSPIAQLDELLSHDVPMPADKLAELADVYNFGQDDLVGVEDLFMFM
1647	DVYNTWPAASCQESIKPIPPESSPGLVYDFDSVFNSFEDNFQDFFNSLECLTEFMHDAGPSATGCRIGPTDGGGGVFSTTGDWHD
		1648	PPNVNHAVVVHANTFNDVYDVCETAPEPFHPIPPMFDAFQDLLGMNLDDCMSLVPEFDQLPLTPSAVMDSFHDETHGDVLWESIG
1649	KTAPEGTEFTIPHPQEVEAEQCFVQPHVRDPWTPSLETKNADKDTEFMTCISTEPSMDQITNPLEDVQDDDMFYHWMDAWCDNVF
		1650	HQPCWVGDGNCPETPPAPLMMGGDVDMEPLWDGDFEPFSFDEPCTWEPSNIIMELDELPFTHWDNDNNCFKPCVNWEFFAEFNNE
1651	MDAAEFPLAGTSSCNPDNCDGLCHQEYHQSDETPPFVERPSDDMESIILTDLMDVDDMDFTAFPDGLDYIADGDWGLWVVPGFFE
		1652	HETITVSSISMEGPSGDSLTAEDDSDYAPMPSFLIGGHTEYPTLFGDDDHAPWAEMRVCASLDAMDFADPQLFMDWLAIPDFGSE
1653	GCITPWLSPRPAEVEWPEIPFSEEFILDILGQPHPPTPFGTPSLHDLYMVEFDTPVNDPNTSSIDDDHLELLGMKMNGGAGGQSG
		1654	WDFDWVGDSIMDIIPIEDMFDEVAPRNSCATWLAETCALSNIDTETLLDMTAGEDLCPSNDAGILSNLDEMEANTVWQWPPYQDE
1655	DWCTLINMSPTPFYDGPNLVEDYGSLQDPEETYQTPFWPEVLSGDFTEESLEDLALMGMPAMPNLDCLQDVDCEQPDWGDLGELP
		1656	GRGVSTCCSIIPGLYDETTNHWADVLMAPLNALDDFDLDFLSALPSVDSMEPQSWSDLLDLDLMAWIGSMDPPECGRPADEKTSQ
1657	DWEAHCFERFPPPPFNAMWDHGDVQPNPEPTDPSADLDGFDLTSLDCMLHDSIWDTPMIEFMNELEPGNRENPTCALGYEHTHKM
		1658	DHFLAAFVQPEPNEYIPIDDGGQFVDDPPPPEPLSFATGGPWNIDEFISSDVFNLEHFLAEGGSPWMMPDCALMDDDLTDLSDHR
1659	LSHAPTMDEMPSIGTVMFDDAVEEPGSHCTDMEYDLMGLLSILLEESSEPMSQLGLFTGGTTINPLAQLDEYLMSTLENDASPGN
		1660	PEEFPWWSSFEPLELEVPEIDDVTLPWPMTNLGVSTIFPQDVYLTDLHFMLDLMGNTDHGPEMDTAMDAMCDQDVQEPDGWPATP
1661	PTNPSSNPGAHIIATGSEWLDWSWGDNMGDPLEHGPTPCGTPSLIDLWGMEYDVPTHDNSEGFCNDLFGVPDDFWQQQFQWCQEY
		1662	GQMIIDTWDVPSLDSPNIPLLQFEDLGTLDEFLAWGPCMLNDEFWTDLFMNDSYPALLGGGELDRDGNHMSGDICMHGGRHPGSD
1663	GMTDSELSDEPALWGPGSQVSPPPPHFDAHDLMLDYQDLFDLDCLGRLGLDELDSNMLFSESGGGINWPGQHQVIDGCGEIGPSQ
		1664	EMWPFPEANDEESLVEFWPWRDPSPNEPFNPCNTDSFGDMCEALDLDPLPAYVCNMWNNDVDTDWNPDISLAPWVDAELEIDETF
1665	VEWGSSSGGTWDPPHDWVDPIQHMWDCPPADLDGMFIERLFHDELWSDSLMPAPSNMMGYDFDAYEAEHGITDPWDPTDIGNDME
		1666	DDISMPGSHVDECNGDSVDSPTNPIPFDPDMANWETAIDDTSDEKLLDNLPSMSGTGPMWGLTLSNLQGEDICTWEEGLGHWCFE
1667	DTFCPTPSAMGPGLSEDLTPGCYQDALPMLDHILGCPAVSDLLGENPKDEGMGIFELLPESWNPSLEQVDLDGYLDTWELGGGEG
		1668	TDDGLELDDFLQPIVYDFLAETNDFDAPPQDYGAGHMLDGSDLEMLTSLLDDCHFMGPWIDDAFCFMPSPEPQDMTQDDFALDRQ
1669	ENNAAPGHAQSPIAAVNPLDLPDPLGDHWFVWNNDSDAFWDILGEILSDIPSLGHNDMDNWFDSLAEQPSTPGHWTWHPEPPGFI
		1670	EDDCYPPSHSQPPVDAVWVYGPQSAPIDENDEAVSDRADCNVWSPSPGPEGLGNILSELQSLDESGNFFTDMFQSDTWLDLPHML
1671	QESMDHVIGTPFGTPSPHEPYDPEIDVPEGDPWELAHCDLFHDIDLLADYMVSMIGDEQLASKGVNNHGWGMQGEACSWNNHEQQ
		1672	SSAFPEPWTNLGLLEDLLPSEYWGFCKAESTAIQGSLLDTSEDFLAMLPELGDLGSLLYETAHQQVDAVPDEGADSTQGGGQDVH
1673	WEWFPLDPQAACPSDPNEHMEAQEHLTFQCDHTVPFCPFGTHSLHDLFDLDVDVPEMDNMLQEFWQDELAMDANDHDEQAAPAWE
		1674	LPGEKRQKTDAPPPYIFFEEGPCHYNEPCWDMDLMSPDTVEWMMDIPDLSPAMAPMNHDMQEYWDELFPLFDIGDTECVGDLWDA
1675	PSDVLQPAEEMFDDMLWCLPNEINEWWPHEPGWPMGGISPWHALHGENEDVNVEYLQIYEEDCATANMMDSTDVNQDMDIPQPQW
		1676	DWRTDFYCVTDDIDIESVMSGLGLELAEFQACAWAASPPFQPVQECYPGRDMGEEFNLDAPLSDGNNWELDDLLNIDEFASLPDD
1677	PDMNDSMGEACPPDTGPSILVPRPDTPDILGSPHPFFDPAIYGWSTMELFDPLFPELHEIGGLFEHGGSRDCTTYTEGGGRPGGD
		1678	PDAGYSQVPMPPEGGEDHEYLEESPYMIPDYHYEGIYLDNFDNFAEDWFWPGIFDELLCVHGPPVGPMLPTTGNSFPPDIDGSQE
1679	HVQGADRMWDIPEWLQGMTSEHWYVVDATEPMESSQPGPTWGGSELEDWDLGGLTSLLEMGEYEPAHSPIPDTWSLDSGYNFIGQ
		1680	TEDDSPSQSTIEPALQDILLHPIITLDDDCLQNMDHAPGDFLDPFDRVDALPPPDPDLLEFGKAWGQLDDLGILLPTTSMHWNYF
1681	SPIGAPTLMFPDDDNCIEIANWCYSDLGGLPWFEPRTPFGTPSLQELIDMENDVEPPSQIAQACPDSCEGMDSNIMLEPSAWNSG
		1682	DDLEHLEGPCPPGTPEAPLPATYGRVADLWNNHSSTPSPWLLDFELNDFFLGSSPSAKETSEPVDFLPADYLPDFDLSPTMDETQ
1683	SMMDVMDPIMDIVMGSSQGTGYSCDVYQHPQPPNPEVAPVTEPMELGNNPFSEAWVTATWDEEVHHWVNGLNDPCDFDMCHWWVD
		1684	DDDVNRGPWYIPDMFQGGLEDLYHLGPPEPSWTSTESWLGDLFDVEVDGNAWGASQFAGDNWLPEEALLEAYCEDIESQFCRKIQ
1685	DETTGGFDDMLIEPPISPVLLPTDSSCQLGDLLRPPTPITEDLLHNLFGLDVFPPESHYMLWDDFWVNDEFINRADPGGAKPFTG
		1686	GDQSPEALLPEGGDDPMWPVVSELCQPQTYHYETADVDLQPDMWISTTNIAKTVEGNEDATPMNFYQQEEDIIWAWLYDAMMCAC
1687	EEDHVKYDIWSIQNAFHEIHNMSNTTGQGLVWWFHRHETGLWHLKLMACYIQAAYVKTSPDVWPFNQYGRPRADDINNFMCFIKG
		1688	TMDDFMPDHINDPPKDYDAADPVLDNETLPWALDHCDLDDLWATIWTDVYTSQPNLSLSHLPADEETPNDTPGTWEMPLFAQSPM
1689	YTPDTNMGPLMSAPGDDSSTSEHTGGRTCGGLVSGAKGMSRLHTAPPTLDLGDLFELLCETANPQGPMQSLDDFDLQGLLDGDVM
		1690	ALLDDTQPPPLHSYALDGDYQGGHFPSAIDTFNSSVSSVGSEIDDWLLSDLGDLSELLFETACSEDWLESMYGGWGDVLPDQALL
1691	AFDSQQGPHDQAGLSMHTGIPNDVLPDVWLEMIAETIGQGIQYPCHDSTEMYNLPSPEDISSNDGMCLEDWWDEIMGFTPDFFPY
		1692	FPNDPWDTSLPIDYDFDYFNAIEVPDPDFLKLDSPEMSSLDLFAVECDQWELDHNMNAVPRMFPEHPSLEAEEGSMAAPTTGCGT
1693	PLLPQVPPPTPTDEGDELPLPGWDVIGDSADAHCVFELPMPGDIDQVFEDMLPCMSNPYGWLDEADFEFDIQEQMPPGVHFEGTL
		1694	ADMIENLYAQECPAMGDIAEMYHWPTDQTPHPPGWEQYTDIYGLCYDVDLVPPSTSLGGMEPLPPDWECNLFELSSDWFEGTLSF
1695	QMRGDDITDPFMFWGFADSNTLSPNPRRCLEQLTNPEPAPTWSYVSDGVEDEIAQFMDNLENCWHDWDDDANQPSVDPWSWLELP
		1696	DLSGHRTSDDLGEAQPHTWDSGWSSHACPCKLPFYDEEDGPEIPAISALDTSLENVSNHEEDWSTLMEFFFPDMTCVMEDNRPFF
1697	EMAGQSPETSVALEEEVGGLWPEQSNVPPPIGNNLTLSDLDSYVDQDLKEGLENELEFPVAPFFMEDIFTWASEGQIQPLPSMDM
		1698	NEAHGNCLDNAMQRFNDAFECFDVTDHAEPWRSENEMTHPFFSEDYFLGLDFNDLPFTCDYEDWEPIEECVCQGWMDPCAFTPDI
1699	NHDFDFNLNAWADIPDLNTVLPIWELDDAAVESFFFSSEDSTPMTEGYSKQTKHTFPPIQGTDDPYWGENMQTVTFIGGTWPPCC
		1700	VVENSIQSVHWSSDEFITWLFDTDLTEVTPAVATWELPVEEPGMDLPDWTPWPMLFPNPSEEGTWNMADLPHDQLFDMCDQDLWT
1701	WGDGCDSSNPMDLSPPLMDEHFSEDEIFPRDWDLDSFGLLDLPDLDIPEEAELMDARLSFLMSGGLGKNYEGPGVDLSLGSELAQ
		1702	TQDLCPTGADPIDIFEDIFATQTLDFDDALQLGIEGLLDLPMDDMWPSETGLVYLDELLRQYNLMEAKESPIAPHDNVSLYPGEQ
1703	QFDDPAFDELWNAPPSLPPEYVNETMPDFLHQESGSIFAPCELTMPSLGEMLLILDIDSQENMEGFEFFMQPNIEESNIHTLGGE
		1704	WQGLLPPSHLEPPTLLEDGLTYEVEALDQMLHDCNTLSPSQLMPPAAPAQPVYGVIPLGQLSVLPIGPTIDIDSWEEFLQNILST
1705	NQPDNAGNYVMDDLDLFMGLNLFPQKIIPDIGDVEFLWAPAQCLPDPSALDDSDLDLLDGQAIPSSSQSWGLSFDVTEHTETDRF
		1706	DLDGNYFHSSPTGMWWDDFFNEMPVMELPVNCTSNELAIDPDGLEDLDMLGMIPELYSFIASLDNFDPAQQASDVVYEEGGHSGM
1707	PWAHAQHDDLMDWLMEYFDHDATNFEPVPRTQDQWQPQCFSTADTDLSIYLYDDIMPNVDWELVPCTSADQDWCWNQVTPQPGDK
		1708	DNTDSPLNLTYTDMEPWQPDEEAFAWGSNHALPHELVDFDLDITNLDFEEGGLAYYLAATNMSFWDFEFEDWYFNAHGMDMDFLE
1709	FLKAETPTESQISMCVGTDPTVHASIMQPILGDEPHPTPTMGEEGPPLMSPWTEDDPFNFWEVADTRIWDVLTFPDMSSAEEWWQ
		1710	LEQADRAPNALIEGLEDFESDHCIQDTPDFCFTSTPDITQDTMYPWIYDPYLGPGFMEEFVYDMNPPEMLSIIADTCQEGPSTNH
1711	SWYEIHVHPDMAISAPPQTSPREVNEQRSDNYEPDPLEPFYLPWPEESNDLAEDMLGALNFPEIECFDWDEQLRSNDIDSCGGHY
		1712	SEGPTSPYVMGTPSAAEGAHPEIGNAMTQPAQWDCQCQLFEYIDANNMCHEAPEGLLCAFGFEDLNDWINETGEGLEWLLGDFTY
1713	VDTDLLAQAMTELSQTVSQIPPPPDLPCDGCMSEALDDFDLTLLGDDEHWDGLDMFAALFSAVNEHGKCAHMETPVWDFPSMISW
		1714	DGPTTYYVLPQVPIPFEVSQEEFRCYFEMMPDPSPAQDNAFGSWMYQSDDWYEDFMQQPTSNDLDTEVSDWVDFDPNTTNSEALG
1715	SPTHPIFGPTPAFEEWSPECLGAAHHDVWWQCFDYTPDHDITQSLPQNNWDVNLEMFIQHGDPEMYGGIEMYEELVHGDTPESQP
		1716	ETENDVEVYVANHHGGIFEPEQEFNCADMPSDFPPETPRTMSIVGQELLDLGSLAEWSWDMLDGSPDYDQEWEILLGWGDKFMLH
1717	TDDTPANEPDMWWISIIDGPLPMEPQQTVQNDMSSAGPVAEDLFETLHSRDVWNVGPDTYLNDECLLQMGGDPEYGGIGDGFLFN
		1718	HRFTTPSPSPSILHNTPEQTVGEGLGFKPTTENSEALDAGSISEDISDELMSSHDAAAYEWFDWEENHEIGMFLDMLVNPHYGIN
1719	NAMPLDCNTDMGDGETLNINLPSHWCPHHGVDRNAGWATSESAHLDMEDFFPDMWFENVYAFAPIQPVSDQDSINTGLDDFMADM
		1720	KELDDFEMDMEDFLPGELHDLMFTHFWAEDTVWLDMLESSAFPDFDLDMLGAQLPMPEDAGNLHAPDSKTNMIDSWSELWALSDD
1721	DPMCLTTNCYTDLSAIQQELPPQWQECDDLDDLMTWLSNSDAELGLEDAMRFSPLELWGQVALSDFGGDLFDGWGGFGDMYTPTV
		1722	PDEPTQDPGDSWFQPLDWDLVDLEYETGPYEPPLNLEDQGYHIFDSVMDEPMSQWWMDWDSWLLSGDQHPQLPWFVNENAAGIDF
1723	GGRTEPAPDLASSLEDILFADQSPSDEGALLDQLTCALKDDPAESLTDMALNGEDGEPEITLWDCEPFDEWGELAMLEQGCPNSP
		1724	SPQEGAGPQCSHGPPLDSQQVADEFAPEALVSPCTWSNNDQIWLEEICNDQFPIDDEWILNLINPIWAFDLHAGVTEAEATDFHI
1725	GTRSSDEQGQIPEDASWALGLADEMGSEFNIFVPPELPDFGAQWDDLDFGEIFNDPWEMYSYIRDFQLSPSALPHHPNYAPTHDA
		1726	DQDKDMYSTLMDDPWIFTSHDVELDSYDDFLSEWIWEGGTYWSFAEYSNWQDPANLTAPEQHPDNVQSGIGSQPEQPASHPFYES
1727	DLYDFDGIFDNIQMIIDDGDMWRPDVDPSWTPPEPLSDFDWTLLNDPAVQLPLMDPLNGLEWHQSIPSEEVFMSKIEDSNFAHDC
		1728	DDDKNEFLHWLPLTDPWDLELECMCEYGAPFPPCQPTLHATQDIEDSQNMSTELCWELEQWAESSIDSFDFPAEALPDIHDAWPQ
1729	SMPPHANGDLICPPEQQWEELQEWFNRDWCLPPLEDPVEHQLSEFSMSEQTLPGLPDDLLLYELVHQFEAIFDDMSYDPVGPMGI
		1730	RTPPHPQGPTCELPGEPMDLEPQSDGNMHVSSACDIRDLMDGLGIIDELMSTDGQCSSYLALDCPWWEDDPMFTDPLGQMHLGGW
1731	CAQQNNPIPAIYHQLLDEVSDVANFNFDSLGWWTTPFSPHSTDWAQQMEPLEDFDMATLNTCDLDLFDADYGEIWTDDPMWTEAP
		1732	PYAVDAMIQPGFPGPIPYDLEPPADWDNVAWMEEHINPSYCADLFLPTDDLLPYLQREDVEAAIWEPFFHNLAPNQDMDQDAPYN
1733	AQDDDSEDDHAEWDICHVELNAQAAAADLVSPVMQGDHPELNAEDLYWCFPELNEAWMNFLNDEFLTADPTNVINPEGTYSQVQH
		1734	DITSTEQDSSTPEATGPILFEDLAVYANQSSEDNNCNPFYDLSPDGPWESMSLDKFMMARDSPTPAIDLSLESRMLWDIMDVFDP
1735	YEGFSTIHMDLWQTNVDHPCTLPDVPAAPMHCEDPDTWMCGLEPLFEDMFMDMDIDFANWDDWALEPINNLGATRDEHPGASTKV
		1736	TSMRQSQIMTDVHNGQTLLNECDFSAPWHIDLDLMGPSIADWSFDDPDLDILWSFGMMEDVPQVSTACNNDEECIPDWGTTQSAQ
1737	LEACAGCQAETQGENWADMFSSYADTPWEPDLLPTWDGADLNNELLWTEPWTMPVDGLNAVPMFRQAEYPHHWDPMAESPEWQTP
		1738	DMLRPGTHTSMQDGDPAGQPPALPHCVDPPSNASEWMSLHDFAFGENMAGEDINPMTMPLGDVLELLETWMPLSSWNWHLDEPNL
1739	FDDWDEAMTPRSGAFDLFNQLSPEDWSLQISCPLEDSLTVMGELGDLFGVLEQDFPLEHPYCGLLGGEASSEPPGGDGGSGLQLQ
		1740	PGVNMRPMQGEAFELSDDFKMLEAGAFAPPLSPDICTPWGTGSWTEPSDDTVSGWAGLTSEDLYMADPDWLDNLDWGEPLGWVCK
1741	FDHFWDITLPPAANDPPSHCSETTGPQDFPDLLTDPTMSHQGMFIQELPDWRDLAELLGETTSPLMPGTPLGMLNGDGENDFSCY
		1742	HSILDQNAPDGSCPNTMLEFDSPPGEGSGPELDMDIFMHDNWDSVEDIWHPWWEVALNEDFAGTLALPPIPDGLAATPWGTSPNW
1743	TSQEYLGSMEDVCENPGLPDTYFDLARFDLDFPRTPTPGILDSWIEDIWGGSDPMMTPPLLPNRDFTNSTVEYLAFCFNTLGSSE
		1744	TETGSRGSSSPDDSLDLLPEAEWLSEWCPFDDQLNFWEALDMDMESLIYNDLSPGLVLDFIDDNWGGPALGGIDSGYEDDAGTSS
1745	SDGPVIHQPGTTMLNEMDEHLNLWPQLQLEQCDLFWDNPFYEHPDLNAEDPWEPLTFDMADNSEMESLLAHACNEWDMPFQWNTP
		1746	QPSWGELPLGMPINEWFQTENDQLFDPLLDWSPMSETGSGLCGLSKQGTFDEGLADLLRDALDGYCVGDGSKQQGSCIDLGGGGV
1747	WPDPPDDANINYGLTFQHPNCLEANFGLDIIEDTDPQVPILDEGISQRWLNDLNSIDELDIMQCMYDCYAPAEPEMQPMSQDDCP
		1748	ADPGTSDHGGPDALDTASMWESCLHPWDVMDTPSMWPFPCDVLSDPEVQSAWEDPLWEEQQETFPYFSGAEAWETSYACGSHGGI
1749	SPIEDTGDGTREGSISQAADCGGINLGTLDLGGSPGLSSDLYDVLDSDLYHDPDFCGGNGRPGWDEGSDLSYQMFELLGMPPSPF
		1750	QAFVDTMDGPMEWPMICVEPMPDVDPWIECSAPATDLSWETFMVDLPQMSHNLMNDLENMELTFHPTPLGTSAWSSSKRSEENEP
1751	LLGGDSMLEGLPDFCVFPEFEESELFAPDLMNYQFATPHSEPWTWEITDTVVNPPGSNAGQPTDDEVFSPYDYWSYGPCDILHSD
		1752	GTPSPTTAQTCSDHIATPEWPGLYDVPTLDEPDEALPDLYSGMPLGSCLYSDAGPMLEAMMGGEGCWAPLMTTQDALDWAIWAGQ
1753	FEDFGPAMSWLWEFDFDEFHLVPEDPDTFLGPLGDNMFTPGAVDQNLFECPELNFNEQAVNLEFPWGAMPKDDEAEQGPPIDLHI
		1754	DQDPLDSFPHTMENSDAEQCDETINYAADQPDHNNPHGCEFDMALNTVDCFGILYDTWDPLDFAYILGLGSDPPSSPVEPDGQYQ
1755	LCNMTTFNPVLHRVTQECTEFPTEGSWDTASDAPHTVPASELENDPDICFETGWLDDMNSACFWPEVLTNTWDDVQNHLPNEWDT
		1756	IPDHMQMLVEQITDSQSCEWSWGSPPPDDPSICHESITPILGEFGWQTPPPEESTSTDPLFNNLVDNMFACWPESELDLMAREAD
1757	WFSWEWYPSYKSMFCAPPDEGMYLMFVAEDDWAMIWNALHSEAEAPPAEFSAMVFHGTCEGCQWDGCMDWEWYHYITFCGEPDWF
		1758	FDWFEQKPCLQEQTPYTPYPLQGPEACVDDVLDLVCSDMLEQMSNTDMDSSLPALLDMLRDDTWNLNQILVPNELENNPETGWGQ
1759	YDNTNPPSGFENPFVVELCDWRDTIDTDALIGPVPHGAPDLSMLAFQEFIDMLTMQLAEGSGSQDMQEWGSDWLEQPATGPWIIP
		1760	TPDTWCPQAPEGNIDEGPSTHPSDDFPPLPEEPTTYWSDALRDLSLDPLTPELCTTSFQAADDMIDFEQWFMNTYCANMYAMNSS
1761	SPDDNQPHPPSRDVDAQDIVPYVYDPFMDVQFLDQLGHDWRDAASDAVYDFNPVDDQYFTQMTQTTCWLPTMEMIQHPWEGTDTP
		1762	CHQDQCNADMPGSGDLWMSGHCYSRARTPAWEMSAIEGLSMWPPDDAQSVYSQVEFESLLFPIPEDMRECLDMDLFDLSLDELPW
1763	DGPPKDTFGQDWALRPPLCDENECFADDILGSPSALFDMFDLSFSDLILPGYESFFGLGNTPADDAPFNMDDNEVWNEGPGGGAW
		1764	EAGIIIPDSQPLIPETPVKILPCAQDAHDLSCDCINCSPEGGAQDSTIPQLDMWGGSGILSELDMLDLPGWPEYIDPAELDVFWA
1765	ATMLTFPAAFPQEPFPLLDEMSDNEFGEVPSMADWAPGSTAETDSWFSSPQPAPEYAAQAVAPPQLDDVSDMFVTEYNPCLWWLS
		1766	HWPPMLGPEVEEPPFLEMPPEEWYSDEIHTCSYDEFHSGAWVEIDMLEAEDGWNDSWLDGQFNDNNDTPLEELVGSLLHDFIPMD
1767	SMLDPSACAQLFDISMWDPLCEAEADWAEWWGIAQPGAVMYGNTQLDPLDWLMPSAMQESEDSMECPQFWESGEGTSQWPGWEAL
		1768	FCDQNHENSHLANDLLELLEPGWGDPYPTPSEAPEEMSLHDIFDVMVDGFESLMPPPLGEPTTQCELQGMTICTWEEGLGYATPS
1769	PEWSTNDLYFMDDPNQWWDLDWQRPEPHEDDDHMMEDHPFHEMLGSFINPPPAPDSCCDHFFPISDSYIFAHDNWETCTLPDMFP
		1770	WDDSIEMWPPYDLMEDMIMQNIEAVHASQGWCWDDSAHSQAFTHPFCGAPTDLMVRDTQNNEAPASEWFEDIFSDMCSNLLTTNF
1771	DWQLMDQMSHPDDWLCPELIGGGFSDEGALLDQLYEALVEFDCTEEPDLDLSLPELEDQWKFPAPPCPPDGDSNWYTGGPTEEPA
		1772	FTDVHTTSYPIVPWIPCLQDLRTYDVPWIPSPIEFSPEPLWLPNMLDDLAWNEANLDFKDLYDVFYEVDGSFHAQQFPSSGNGST
1773	MNESCNQCYPNDDMLYFYEAPGYDIWAHWWPPGSSNATGIFDWLDLEPSSSSGSVPASIPPQTPQPSTASEALSDFELTFLGLEG
		1774	RDVEALEGLLDGIEDMLDYAMSWEPCQDCTPPDWNPGPLLEPLLAPSSNLPNLHDGGGLELDHGFSGWLDDGGLPESGDEQWLIG
1775	PYGMIAQTVTDISLPELPDWAQDPFANTIPLDDDMCHPSMYTELWGSTEFWDESGAGMWHGLIPNPQELQDWMDDFPLASEASVI
		1776	PDIDNALWQLVWDFNDLEPWPDPMYDFLEDQLGSVGYPVESTGTNHPQQSPVENSYTDLDAVCWTLGPVMYSDEFANLPVHGPAW
1777	MDEENSCDPTISENMPNKDAHMAGPDGSFWSLLFTELDAFDEFIPESWTTPELNEILDTFLNSECLSEEFNALPYGLGLCSHRGL
		1778	IFDDGMWGSSMQFLNLPPQHVSPNSQGHCEPPRESTSPANSEYPPQDELWSAFDMPDLWGPEVWASDCPLSPEDDALIMHALWDL
1779	DLCPFFRTADATELGEIQCGCWNREEPSETYVQADAMFQNLPPSFPPAFDQPDWHNMPATPFELDNDDWEPPMCIFADTIDYMMP
		1780	FECMTPLNISCSDDEFDWFNMYNTEANCVPVMEPTDQWRLCELIDLDGCMAEDFDAFAGMNEVVGMIPSPAEPIPEPHPINDEYP
1781	GGGVARPMPPTPENAPNMEAVCMAQGCSPTLDLTLEAWEVSQENLGSGPEQSAAALFGELSAPEHCLQGWDDSMFLDWLGNIIEE
		1782	ASDDVFMDPLFANLLNFDQNTTSDVLAPHECQAHAPFNPVMPVYEPHSGLRDTNNMHDLLEDLLKDCEGNLIAWLPEDIGYSPMG
1783	AIAAADPTDTNEYVAEWTENLSSPHFYIPDVDQFNSFEDFFAADPEAQAMEPSDPFPLLPCDFLALFESEVQQGVIYSIFQDPLD
		1784	LVEMSCECPQMHTSMEDVPLPSEPMFDEPITWEEPAGSSDLNTWPSSAADLMGELMGLLEDDALSLTCMELDELAAHGATRTGGP
1785	TDGPMIDLEGLGAIPLNDPKPITIEAYYAATHETNSAAGLALGSPLMHAPSDVVSSMMENLFDDISWNDEFWFATIMPDPEDPWQ
		1786	GCEDPLMALIQDDLLCPAQPASEPFDEYELLRELQMFSSQDLEDVFSQFDNDLYVMYDVGPNFDGDLDPPPSWLVGQLSAEVEGP
1787	PSMWEPGPPGDVFSTIDESPNIDPDAWAEWTDNILDFLDPLSPQWLYALFDNSGDPYPARDHPTVDVNNEFISPNSPGEMSSQAG
		1788	PPMETNTVHEWAPDLPDDPHVSSPYQALEQTEQTHSSWSGSTPRLSPDELMNLDITPLDGSSPTAWLEGNAGPPEYFCLDWHDGL
1789	GCHCSAPTNMHDLLQGTLFGVDESDVSDQVFNISPMPAIWSESPPLPVDEMLFDLPLLAAEFTLDEWDVFNPSMDALANAQSPEQ
		1790	LANNEHSNWDDDPNLCNLNYAYTEEDNIWPNLTTEHACVDCWLQGWEEIDNMDLAWGIANAWSLMDWKQDTNPVEEGPSTFELPN
1791	GWDLFDDIIQESNNEQLLYAGLLWQPALPSDLDGMPIPGSASLFDLEIDEFNKGQDLPCFDDAARLGDGSQASEASEDWFFDTLE
		1792	DAATDFTSNPNELIELDDDTLDNEQSYDMDDFWLDAERLLALEDFWWGNLPSLGDTELSMPVHTETMQQLNAMVCSGAWDIPQDM
1793	SGGGSVFGSIPTNDLLNMTDPDMLGSGETDLWQPDVLGHDDLSWFDIDYKFGSLLDSLIAVDASEGCKLALDDDMPLVGSEPGDP
		1794	PNGTDLDSFMGGLGAQLQHPMGANPPEFPADLDLDYAEADMEMDTMSLILNDFQDSSLCSFAFDDELGGEGGGLDQPWSNGGPWS
1795	DGCTETGSQPMEHNMDQLDMVHNLFGDDLSQLLEDLSNPDHGGGHCGNGCWDKWMSDMLNLFDDIEWNDDFIRHGQPVVPGGSGE
		1796	YLGVPNPSTYADMQELGNPATMFVPVLSFDDLLFPELEAFDTFIPDSNNSPLGNWLSEAQSDECSNTGQTLDRWLWGYDWPWAWQ
1797	QEPSWLAVSSPFLPGLDDDPLSMQHPMIPDFTYDDFHEIDFNDIFDGLRSHLADEAFGRNSGGPAPGVGSGPQEPYGLGPVGGME
		1798	GGQDGVENGKAPRPQVVQPEPFVAIADYFASDMTQLSPHRDLFMGDFLLDNLDAPDWSFDAMWGWQVPQPAPFQPYQHPDDDGNA
1799	NRDSFGPPVTGVFDQLLGNDYLYELQAPAPWDASSAGPTSPYPRSSTNLFEDVSLGDLWNDDASDPPFNLDDLWHVIDHNMPLEP
		1800	AGGGSPFAMSEGWADPPHELELQQWTFNIFGSTIEGMLDLPDFDDAPAEIGASILGLDNAGGTGAGGFDPGAGQEGEVDMYHDKR
1801	TCAELNMEHLPAIWEDAWPPPTDSEFAPYDSQLNPFTPRLPDMCMPSNDTPPATLRPSWDMPGVESADLCALFQALGAFEPDFGL
		1802	WENTPNHTGEFDEGPDNAFYDPTWNGFQEEFVWPTTDHTPDNMDVVHPMFMIDMDEADSSDVWAHFCECSGDTLHDIWQLPFDAL
1803	MPLQLNEGEYTWHADMEDHHMDDLPHTFADHPSGYDTYYINPPPFNQLPQMEGPILNANMFRPFLHEWEAANDDPWVDWCWSSDF
		1804	GGGPSGGSPPPDDPTEPKWMCLNHNKLSDDMDGSFALDRLFTDMLGWDPSDALDVDEFGFELGAPPQQGGDTEDEPMMFNMFEYH
1805	HESPDLWCDPLPDQYELFEPGLDGLDHLLGMDQYNIDDLLTQELRDMDIPLVPGASVIDEPLGAHEGGSGSEGDEECHGEKISRP
		1806	THSQDTMYPNPFCVPYMGLWGTDQDADMSPINDQDEGFPSEVDFWITNYVSDNNIFTFNLGQIANEWDQELNSCFETPPGEDMDD
1807	EPAKPSGNGMWDHLEDQLFEFDTVFDFPEPWEISEELFAYPSLQTQNALPELTYMDWNFVESFAEPMQELCRWGLNQDENPHDVG
		1808	PIPAQPEDTYTALIDDDFMPEIFPGIFMDVEINSDEAPWDGCDQLCMDLEDWCHVLDNQIPMPWPGWDVEEFCNFMNLEWFGDPV
1809	IALGDFPQVLQPIQVDLSPPNNMDTPEWMYETVFAASVHPSNSGTMDHSLCPDYIEDLLNWFDDIENPTGASDPVMPSPMWWWYE
		1810	GCMFPDTPWPQNNGIMLEPEPLSEDCGAWWVTTPAPLDAVMCDEPSELPWSPGSLELLVPHLSPAYFMHDEQGWEDCTEINMWLD
1811	ALDVLPHDPWGQWFAEDFTAISEELALNELLDNHNFDALWDLLGDNLSDTPSLGDGQPGGGSSCSWQFGFGYEAGLPAGGYEGPH
		1812	CDNAMTDDDYICFDYLMDPVDYNLFGWYDGPDYANIPDLIEQELRDVDILALLDPRLDPGVHEFGEMSGAEGSPQGGGGGEHYAM
1813	WFSVPEQEAWDTLANLYWGDDGINDHFPVPVDIQPDVLEFEWAMPCFDPIIGPENEHGPCIPDGELPLELAWTLDPGNDDAMHPP
		1814	FPVPEMIDLGTIWPDLTTIPEREEEGEPFVREWFPLDCPEFDLNLDFSCEQHLHEILDTILPDEEPYLPMHMSTGASIFETDFWG
1815	DIDWEHLPGDDDSSMAFDSEWVEHWCSRSRPTCINIPMPAYAGQCSHDDKPLEPGVEAMQFPNDFLESQLPEALMDFEETFMFPW
		1816	ITPPDVDMIDIDPMEDPFMGCYWPETDECSAIHVSAPQPYTPEADLGNFWRNDFSNTDPYHGNSLEEDLCQDLLDMVALDPDGWW
1817	RGAVAPQIEIPCSAPQDEQAPGPVLEYRPMSCTLEHFSLPDLADLQDEDFDGLSNEMQVIGNWLSILENGGMPEFEHFWDLMDKE
		1818	VEECMWEDVIDKIMPPMDHVWGIGPDALCTDYNPGPGPVLQGWLGEVSPLPSVSLWDHGDDFHLSSMDPSSKLDDFDYTNLCDMG
1819	LLDIPTDFDFAENLPVLDDDGQSFEDAVSAWYDLPFPPPRSWWDLLEQEPYDYSCFDELCLDASPMVTPELALADPDLGWMGDDD
		1820	NEAQPTLEDQAWIQFQGLLMDEWLFDNPDPLEHIQCMSTCDLADGCAPPFTPLNMPELWNPLTPEWFMGYDPCEGALTDPQWFDF
1821	ARIHHVMQPTPHEMSCLEQLPWMGPGSMDDVDWSSLGPGADMPDIFDELMSSDVFRVLDLSPLPASGVGTVLEADIDVCQTYDSQ
		1822	PDPQIGPWDALDDMDLLEAPNIDFDAHLLDWLQDAYLDDLSNPSVESNVLDDGLLTTTLGFMGQYIPSHSGSHRGMGGAPYFKPM
1823	CSDSPHSANDFQGWFDNNDYADDTPFACPWPDFASFAMGMPAMPESLSPRNDVPAGDELLLSALPDMTGSEAFDEFMYELLTIIE
		1824	PSGGPSGEEDVVSRNLEDILGAVTSDEQAIQQIFEDSLMCDTSFDDLALPLSQLGIHLGGGTICPFAQDTENLDDNEWTCMLFDK
1825	FPGTFGNWDQAMTKDLPPVLWGPSLSDEWPMWDQLDMPMWADLSDAMNSTEDVLSTDFLNTLWGILDNDNTHCGVGGVCGTQPSD
		1826	ELAQLMPYMTTSQAGVQPEDHLFVDPHVHNVCYEPELPSQNTPVDHENSPLDLLSGGFIEELWDEILAFPVDWIFSDWEEVGTEA
1827	PWLEELQYWDWYLDQNEGDTEALPEVLHDEPQPRHEPPNPPAMEDWNPLSEYISWDFGYCDAGDMWGIMSDLINQDDGAFSPQST
		1828	SSDPEPSNIECGASYMDYFEFPAFWDQSVFEVPLDCRPAEFSMERRPHDDSLAFGEVIHDAIQALMMGPQPYWDPHDDDPPPCCF
1829	VDNPPTDSTVNMPLHPEHSHQAQCFHEPNSCNMILDYINAVGITEPMEQWLHNDFFCPDAASLCEQGDCIPNWFEYVDDPLGWPV
		1830	GTADPMQESKPKGHCQQVATQPDQPDWTMSAGSPKSFNIDESWFEHLFPIDLDPFAFLDIQNGLADLYFEDDQVELSDNPVGYPH
1831	CDDFEIQFRTPPWVGPPMFDQLLEEVLADNTPPPSHAEPQTLDNCYDLDMTLPTWTQLAAFMNIEHAFGGLSDNLNFDDIDIGMG
		1832	FDADASPLADSLFTDIAGNGLPFFNAHDLDASWDPVPMSGWSSWELNDLALSGLWELGDILADYPKSMEGSPDAGGPADFADLMF
1833	NGGTPETQCGSWSGKQGITCEPSFYDWYDWYEFPTAMLQHELPELWGFDTPDVTPNDSIGDLRISPDPMEELEMLLGLPEPWSPT
		1834	GDDNHLGNNGVLNDSNNLIEELLGWDYWGIPQPESPLLYGHEIQIDCWMPCPRYSPEDIGEPMDMPEMDPPHDVPAIDLMSDLQQ
1835	SDTPNNAGSIMEDSNCNIPTLEGYDTLTLDEFLAGSDFGDLWKPIWSDPYDLDLNPFVFVPAITSATDQQIESEPTAVMMDTFAT
		1836	RESVGPQTSLWGWPNDPHQWALHDVTDHPQNDATTALSANKPSGWTIDELMSSDLGSWMCLTALPDMDYNFVLDPNDIDLLGFDD
1837	SVPGMEPPLPPTYWASLGCNADCMVECMPHEAPTTDYDDRVLYEEFDIYNFVDDMMQFTLWPPEMQDDEDMMHAGLDASIPDPGD
		1838	PWDDVNWFVQEEGTQIEDDQPEQPFHPADYITAPTHVRTAAPTFDTYNDLDDLNNPMLDWWNTENLHTWCEFFPLIMEPANQSPE
1839	GNMTCDLAVDAPGGPVWETHLTAPDELPSDPMLDDFWLDLLDHVGQELPPLGVLSKDMLNLEDWAECTDWFSQSGTDGGDARNDK
		1840	DNMTPLLEDLANIDWGAVPLQPEESHCQWVMPPQFSLMYPSIDEMRNPSPMHLDCWGLFSPLQEELEDWELLEFDLNVIPGDPPY
1841	EDEEMWETRSDYMSAAVFREHAIEEVVYDNLWPPEGLEPPNLHELYDLDVNAMDDLHWEEVGQILIPDDFLPLSLNCYEEFFPDP
		1842	FDFCLEPLDIPLCWDWDAWEQDVNAEQNWMPPGESGLQQPLDPYDLDDFALALDEAARTNDWQIYMDDGTQMFLDALEIDDMSGH
1843	DTGKVLQAPNQEQIPKLPLFEDLAAYFDQEYCPMWPGPLLSGELEGWKESGEDAATMLENGDMLDNVMFSLESWPLGPEDFHGGP
		1844	TFFDTDNIGLSNDIPDLFYEIAYMGWPPLADETTQHNDTCELHTTHPETDILLGGVGDMLGDGSWFPFGDGSDDLFDLLGECWAQ
1845	GHAIEELDMLLSLTEIDMTQDVAADHVRHSPPYSTTGGAMNLVLGNQYSNTQAAPAEWDGMASPQQEIHPLLELMPTIYDFEPYT
		1846	FPQEAEDTFASVHTCCRIQDASDAPPFMPSEWGAVHDEIPDASQVLWPNCTDWQDFMDRFLGDPTYDCFEMPFGADEQYDYWPMM
1847	GQGGRSQPGAGPPGPSAPESQAMEFDALPSMMPDDALDDFDLTDSDPSLAQPTWDHFTYALADPHSSQDWQMFTDALACMFFDMG
		1848	DGMDGWLTEWVDTLLLDQPIDDDALCNTLPWFNSCNSWDFPVDCDCICPWNNYDVHDELFAGGMINGPLDNFDVYPISGPSNTSS
1849	RDMPGPQYYGTMDMDDVIPITEHLSTDFLMGFLDDMDLDMGFLEALWTDTAPANPGSQLPGDLLMPLAYGGSGMALGVASDGSTE
		1850	GWGSSYSSPPVVTGPSHPFLSGVEQMHTVFRNDYEFEIPPDLYDIDAPEEALLAAPDVLDWMFQIGISTDTTPESQDSDQDLNDY
1851	FAELADIPCLNACIPCDEDEPMVQEAEWFWNICSMPLPMAEGALPERQAMEPSQLSPLDPGDLMALLETWDPYSSDWGGPEHPAM
		1852	ETCDLLDIDWDALLDPSDTLTGGVGLDDAGPESFFWSSIDSTPAFEYENLEDNGGGEGGCDHFQGMHGGDDGLQGEGGPGNGPWV
1853	DPYSAFEPPADAHETSEHDIMDLLGTLHMNLWPPIDSQGTIGQSGCLADAPDGASEQAGIDELLQYDWDLYCEDCFGIYGDTEQW
		1854	KQSTVGPSLMPQNPQQAWPVVSCDSDDFPQSPYVNHYEDYCPLASGLQTDDSPYTADWFEDLVSKAWQENEEAYQYEFGLPIFES
1855	TQPPVTTPNMMAGTILTLNDELVFDCIDLDNWRNPNIELLSLESPMDVDEWLFALLDEAENMDVPVGSYGGCGMDAEGGSECGDR
		1856	NFAASPPSMEAALMDIENEAYEFPADEDQQVFLLPPTPFQTPPLDMTHDLLMDSPEDTGHPHDLPMLFSFVLGEDGFNVAYNEFY
1857	HDDSVIDGSIMDDSNPNIPLLQGYDLGTLPEFPDINDLDDLWKQAWHECIGDPSTTNTNFDSMLDALDPDAGTNLDAQTECYYAM
		1858	WQWPPDELWSINMQPHQPFLGSGWCFNPFGGVDFADNPNDMIMHDLFNTQESLDSQDMLNLFDDILSLIPAEPEGAIDPEPINPI
1859	TFDEPFMSNEFTALLNNLLTQGPSLQCEWVDWLGASEDTTLEFWEPWTEDIEQGLVGLGFGGGGGGGPSGDHGDTCYVKDPTLQR
		1860	VFDAWLDVVDEENEIFADIMPSCPDIPEPQWREIHHTFTMPMQEEDLEVGQFTFPNVEEANMHSGAPLSTGYIWPQGQDEWNFLD
1861	NAYFTNSTYTDDARALPEQHTNLDDYILQQTWAISDLELGSLSAEIIDELMCSDVFPEMYLWPTPAMDPNGPLERTEWTPEKPPV
		1862	YHRTGRDLGMDGNSSEPLWPSDIEEVLASQLPPPNPGDLLQGHELYMPDHAAPELPNETMIHQMFWDYVALPEYEFDDPTQWPLP
1863	QPAHTDDGEICLPFLAGGLLGPFVDGDNDMTPYEIMDMMDLPDLLSTDHDQLDFDALTDNDDVTMSAFLAWLESVVTFNDNAYNF
		1864	AMNPPSEFMWDMFSDLCALDSTSDQHLMHGQTEFSTPSTVLMSGYKEQIMGVGPTDFDQVDDPSWDSLARWFIEYTDNDPSEHWE
1865	HRDNRDTDPNSIKHPHWDGAPDECFNELEIESLSYHSAGTTILCPGLSQRDQGILPGDLFEFDDPIEFDFNFWNDLATELYMCPE
		1866	LDYPSSPSDYVGSIDLDDFDIDGPGATVAPGGPLRQDEPPFDSDKSDWLQMLFDLGDWTEDATSSWNQTEFPVCAEYDQPQSVWF
1867	DTPFWPDFPQDLSNTNAVARTPVDVQVVDMCDPDYIALNFPYTNVPCDEEWLSEFDNQDLPDYEWFAQWYMSEVPLDYQDAMSTE
		1868	DLGDYPSDGSDGCTMTFFEPLEGLWDGICGCDNWSDVETPEDHIFDFEYLQRMDEFSYQEFDVSQFLGIGVPFGPQYDTQDIIEE
1869	FDDHINDWDELVGQPLMDPLMEFAWLDYECVYEQAPLTLPQSQIPSDPPNMWHEGTCMDSLLPEPYMTEPIMFADVGGDAHESPN
		1870	RPAFEGMWTWMSNDWSPGMSKELAMVEDSFQYFPVNDDFDMTLLGDTELLDDEDLATAYAWPNMDPDAYLNQWTDETWFDFDAHQ
1871	GDGGEAYMPPIPKCNVSYLGDECCLGDECQGPLWCGLDDFSGFLGENSDSWAFADASWIDAMLEEQFGSSLDMIEEDLLACMITP
		1872	ELSACECPSQQNPDEGPPSKVPHLLDQTQDTDISNAGSLSNDITDALMYLDVEPVPFSDIGLDVEMDDWPLEPPCELLDVLAELG
1873	APPCHPGPSSEEHDPLIIFDMYPGDLPMYTPHWQSLYDDLFWEEHCGDLHNMAEVMNNHVNDQFHTDELGQALDDGLLLNEFLPP
		1874	TMFDANTTNTMSTCIDPNPVALDCAGTCCCPGERPANAHPVVFDNKLCFEQFELGHLNELCEVDPTCACEVSPEALGWDWWDVLG
1875	GDGTSEQPGARIPGDPQAMSQHLLHYLTDINSLAEDVNGLNDEFWTDLFTNDIEIGSWEIKEFIEGMNFEQYGQGGCGPQEGSLG
		1876	TCEGPSSNDKFAPWLQDLHFWPPPQVLDFPNEDEGISPILAQPQNHMNTDTESPPWHHLNYSLYPELEEWDHNDFLSGPPSPPPE
1877	ATVAYPQSASSDSSWLPEDVDWMHVLDDAFDPSWATLLAMSMSGDIIDEEPDAHDVPLAPISPGNADGLQKCWDFFDCWWDEYMQ
		1878	LNDNTMGGVAPMDYNFGDLPDSHKDDFLLDSDVYSDLSDFDLGMLDSELAQDSVDAAMHISELMEDLGMFGEWFMPVFDSSCWRQ
1879	DAYVDSMVTILNDLECPLFDFPEPETPDILGLPTVFFDTAISGWSNHSLGDPHFPDLMEESGAPPDGMTCDGGGGGGNGGGQGGI
		1880	VPDGPDLDAITDIYDDSLLGMSVVDDDDLWGLGSDALDGFDKDMFQSDWWLEEIWGDVGNPALEPSPGQSAGPAQCNGLWGHMFP
1881	SPGMTPADSSASIFELLCPIEPCPPPLYECHEPDLYCPSFWELFDPVNANYQGIMDALDENWDNVLPNQDMNASDRGDGTFEMVQ
		1882	MDNPYMSLLQACLESDHDETAYTDSQATYLPACPPWPFDFLIPDSPQWLGDTPDIVGDACPPGSEWCRADFDFNSEFPIMSPWFE
1883	LIECHPHMMGVQPSPPWLGDDIPCVLDWPPLSYTEPRANQRHYATMQSMEEAIDLDQFFENIDQPCFDLQDPGCDCEGEAGCGFT
		1884	YDEKPEQIGVWSPRAEANDDICHDHTYMECPHAETTSLYPLSLFDSETPELGPGDDWGHFYNGVIPSPLNSMIEQPRWETWDTMS
1885	RFSEAFGGWQWYDMFAGMLDTSFYGLFPELLETAEPTSMQPEVQSTELSDLGDLSELLCETPSTETLANFAQHEWSHGPCDSGSD
		1886	NLDRWFADHLMDFWDEFDCAGFSFMMSENMNMHGYANVDWDMDNHAFEDILADWVDGPVISELCEELMGPDDPQPLLSSQDGPDD
1887	PEPGPTNASMPSQHLQMILYPEMPCVFPSDCDMSSRGSLHDLFDFEVDNWESTVNMELSPAPRWDLFGPMDNPAAEVEMSGDAAD
		1888	FSSQPSWHSSIMNLDDLPELPGSACDESLVNMVPPTDLSDLDNKLWWDLWIPSVVSPLLPGDVDALLEPWMPGDPLEQLAGMGLQ
1889	GGQGSLLQSETDLPAPSLDTREPSDGIVPDAPQEDPFWADIECILGFDGDGLRDLTFPFASLLMGDDFFEQMIENTDLCQMWGGQ
		1890	WHRYSQQKTVVDVYPEGSGSKWESEQEPPCDSMNFPVVEHSIAEILENALKSDGSLEALLQDMDWLMRLDCDPPTDGPLGDDLGL
1891	EPDPSSWAPPCYDWEPVLHMPPIFPECMIMNPSETLDMELEDMDLGHPAQGDDFNALIDASLDKPDATFEQMFTICISGPDDPED
		1892	LSVSDPFFVAQMDLFPEILGAIPEEWLADLLPPLAYHPDFPLDMLAEPRDPGADLQDLGSTGMWWESMDDLGGPSGPDLVCFPNK
1893	VPSDSTPSGFTDNEGDDDKPNEAWSHAPRYSYMPEWIALHSHEPLISDGAQLDFDCLRDLDLTGDAIFLDLLFDFDNEMLGPVES
		1894	GHDASSDGSLLPDLFDELHQEHETIDVPYMPQLEGFTLDMLGSHDSQSEWSLPWDHAPYYGHILPPALGDEQWLTTTQSDEDFDI
1895	DPADADSMSAWDPFFHELLGDDMAIADQEPEDIIHFHPCPHDTCMEPPLHEPCCPICDIFRDLTEHCNCFAELEQFFQDYVTAFN
		1896	GSSAMDLDDDVSEFLSAMDVAPDPVEDPQGLHLDINPLGIMTWEDAIWLCADDSSFHNIPGLDPGLCEALADDDTDFVWWDNWDA
1897	ADSSDFNPNPSMMAIEDLWCSEMSEFAPDLRAFPWATPRTEPTETYNLDWPSGVEGTYEPNDQLSFEKDILDELYCSPKIPPDTI
		1898	ASQPSGPEAGTGPEFHELYDSANVGHQASLWEALSQMDQDGLNLINIEDIDLEMFMHDPFSLHIGEAWTVPLEDGLGVGMGTLPL
1899	TEDFPHEPMEYPSCLPDTLWSDYFSGEHLSDCDFDNLCDDTPHDGLDVPASMNLLPTPVDTPLGESWEHLFAQIIGMNPWMDDIV
		1900	DWPDEFSKLLSQWMDDMMDNCEFPHDLPDPPDNYIRFCDPFDGLEVYESHHSILGTDHVMPDPFQIDLPGDGYGADNMGVMHAWY
1901	DFEVDASQPQYEILQTYKDSDMDEQCYCPSLCPQGPSNPPPASTAPELDEMVRDELHLTELDNIQLWMYLLDDMFEQMSGDGSES
		1902	ERQPDIQAYMDQCNPMQPEMHDDAPQPLNPETPEPSPSCWSQYDQDEVFNFIGSLHSMYMEMFTPNPNLDDDAILSLHWGEHFDQ
1903	GRADPTQSGDAWIWEMMGMLPPLDSLKCFSDMYSTDIPCAPPIPTWHDTPSTEGVTDGLDPLPPSIESLQELEHLLGIASDGWKQ
		1904	IDYEATNLDHLDWMCDEPFGFCIHEALATANPWPPCDDEIDDNAMLDYMCEETPNHTFVPWEGSDWLGAEQEMVEPEHMPWQDEI
1905	TNVGFSDHTSIPIICNLPSIPGPYHGGTLDAPVCYTDFEDLMNELPSDMCFDEGGQGDGQPFWEEVWGDSFPISPETTWPSWVSG
		1906	AAPAELPCDIEPCFCITDNLLEPCVVQHQPLTPYSGLGLLDLDMESLVQPDFLLGDTADDGWDDMWQASPSWPPWEFLTNMCDLF
1907	QMEPASKEAQPLCDDPAGFSTFFVDDFPAPSEASFEAQLELNTPELFDNWIEWMRGTFNGQGGSGRALSEESNMAEHGLDWWMVG
		1908	EPSNSPQDDEPYNTDMGPLGFTPIEFCHFWWDDMYQGIPPMDIGQEGTTEGQTASEILPMNYDSVGDDTFDQMLQLVDIPAWMFY
1909	GGGGSAAPGECFDTVLMGELEAMLGHHSDKNPDVDSLEDNRLDLLSDDGAPLPDLGDLGFGFFAAGMDGSVWPMGAVCDQDTTGM
		1910	GNDDVWPDDTPMDFCQDWWPDNLFDHTAGAKGFGKGDCWLELGLNTDLDLRAEPLDLDGLGMLMDWHALLPDLGPVGGASPNWEN
1911	DTQSPFQFYNDDDLFGPVELESMTFPHVGLNYPPFELPDVELPPPAASDPPLPGVINSNGGFGHLGYELDWHRMFDCPEPLPSSQ
		1912	DWNGIDILFDDPCGNIEHSLLEPSETAPTKASYFCATMFPLEELDQLFDCPEQTSPFDMNMLDPDMDGWSGQQLMDFAQDYDNGA
1913	CPGGSSGANNALEFNIDLVDTHIWEDFCTLETTSLPGSPWAWQDTWEDELRMEPDHLMGLLDLEYPADLMPDSNAFELAPDAQPA
		1914	PTDGADNAGFSTSWSPSDVGQGPWDGSALYDCLSGLMGDVLWEVVPELSDLDQMGLLMAETDPMLPAQTDEGMEPGNIEQDSNGE
1915	IFIDPPETHSCPEEPPIPPSHWLPIPDDLLDQDVLDWMGEDSTHDNAFDPWSPTFPNLADMSYNLPYFVDVEMCQFMEDSGPGWP
		1916	AEMDFFHLTMPQSGYPLMGGRGPQPRGALDELMWSAPPYGLDLNLDSPDTSASCNMLDQFLNDPEMDRAMCDEDLFMLLGTLEWD
1917	DTEDFGWEGMPSNDINGLVYDEDGFIGIPDVADYPTPWLTPMPDMDSILPLMYENIFALPNIGGSQEGHQTGATQQMHEQGPFYE
		1918	NTDFFNFDGECSDWEAWANTIAEPDFNTIYYPIESPEPEWLGQMDLPDVETAYAPFCSNNLMDSDPTPTGRGSEVEELRWWIHDC
1919	VWRAHIGSPSPFMLGEHQPLFFPMPDVDNDELTTYEESMMPTLNLLSPGSEGVGYAMDDLLEELESMDGFWYGSTLIDEETPWLG
		1920	ISEIQHFLQQHFNTCDDYALEPELDVGDSSPGWEAPVQSASGDLSIQAMEYTLADFFQDLNMWEWPNPDAGSWTLVDAMDGDCHT
1921	ATILPIWADEPNLFTWAYTPRMEALQQTCATDISSAEMGLPGTYANEPSSEDFWGLQGPNPYTDSETEGWDTNAFWDILGNMLSH
		1922	QTWDFWDFWQGIGNISQEQEIDEIETWVPETSWTNPLHSPVAIPSHMPAPLVMDDLYLQNDLPPPVDDDFLINYPGWALEDINLT
1923	PDCEDLLQKPEPDQPPSDYPFPEDWGPCDSSKLETDSLMCDTSVDDLILQGLEHDPLLEMVTGGLGDTGYADFPDGEDLCLMIGE
		1924	VMTDCEFLAFSSADEGPSSFVPRCDVLAYDLWPPPHTMFPNLHELCESLTDPPTQWEPPEVGEDLFDESMVAHNVFDLMRGDFAY
1925	QDQGSTLPDYPTFEDTISSWEPVWQECDQGWRGGSTAPDDFQGTSEHHPMTGITQPDMLGSDALDDFDLHMCGEWFAWINSHWMA
		1926	DTPDEECPIAAHVVNSWHAEEHWGWDAWPPENETSWNTLFLGNGINPDDPIAGLDLDLMTFDWMLEMPDLWRMSQLSMSPTMDWD
1927	FDTWKSDLFTALCDDMAGFCEALEKSFDLDNWWAPEATSGAGQTSLEDIFLDSPGDHWGLEQAPVVEGGGSSLDQVMEAHAPSGL
		1928	AHDCCYTALCPHPCCEASGGASDFGDILTSMPYEPPLESDIEWQVYEHCFTPDGIYTLFDSEQYIDMGSVQEWLMPWGMDGNAEQ
1929	CCPNCLLEYAWIIDICQNNWDDWDPFPDPYEIIWMMLITSQCHDEGDRDIGRTCVVHWDDMLCADCENNDEMNMTNMIVYQNNWW
		1930	SVSDYSVATSNGMSVMEEDGVDWFDDFDLDWLGSDALDLLDLFDEMPALGASRAATMSFLSWQDYMGSPVGNMVGGGVSPGDDLA
1931	IWDIPPLDCNWVGITDDSSAACGQELPGMELPEPMHPYPPTLHPLFDLQNVAPPDLLWLFPDENCQMWLDFLVDEGSAPCNGPMC
		1932	YPNNLLEDYWPLENIMVDDCRNDEDVGLSQQEPWTELIELTLHELYDFDVTAPEFPFEEAVSQAFWDLDEPNSYYQACGGSGVGD
1933	DGGPHCVCLPGACQMPCPEPCRTNFASQWALYDIPMMIYEHPPDWASLPSPQPQDSNSWIEDAATMLASDWSTSDFVDIWSILDA
		1934	IGEDTPPCDMIMTQMIEAPPSDGPGEFTPCNWRGSATDTDVPHSQEDFNLATEIMLDALMSNPQWGPNTNCFPDDMLVNLDISHL
1935	VTDPPSQDTSSYNGPVLPEIPCGTNNCDLPEFVWNFAETCQLDLSSECAILMGEEGAFPGLHGQKYGDNDIWFPSLEGGMPGGTD
		1936	LDTQPSPEAAEHVSLVPEDNYYTTDFDDVLKLLGEGLLDLPDLLQAPDWTLGIPEMVAQHQKRQDSNVSSQLDLLMDGGGDGPGP
1937	HPDMEVIDLPILIPEVTDFFDQDVAFTFGDDGPEPPTPWQTPSHCDLYDNNVDVGALDYLEEMTTIGMTFAPPVESGLMNMTPFE
		1938	TTPGTYDHDMYKLLDNIIFQNPPAFEDLSDLDALWMHGPVIGTDHDTWHDISEMTLEPAKFPAAFEGSSLHANFLDDLSNAWDGE
1939	APPVDPQKSDQAHQNLPEMHDMLWVDLTDTSSDAWGPNQLNDEFWADLFMMYDDLWPGGWSGGFGQDEYEMPCVMGTEGYPSDPP
		1940	ETCQGGWQHMTELWPYDIFLGEATEHNVTDVWTFNPWNDLSPDAAGLAAEPLSHFWDDSLNWLDQLELMEDFCGDGEDSNWLTDI
1941	STESNGEQTNEDLGETHLDYLCDTDTHDQFWTDHEFYFPPDSLDDLDLYSAPDVWGHFSALYAPGCPDGGAQFHEGSNPDQYWAM
		1942	PDDQPGHPEPHASPPTTPGSPEPEPSHFPWDPFVYARSESWEPPLSSNGIFDIFQALEAIDMVDFMLPTEPQNWAPAEPQSRNFS
1943	NDSNFEDPDWAIGMPDEYNCLGSPFMSEEYTGSDREAYLADLDDLLGLWDFMDEDLYVEEMAGLPEFEPGTNNHIWFTDMCAENP
		1944	EPCPETRDLDEWIDDYFHEFMAITMDVPMLPPTAGQTPSLDGLFETSENVSTEELWFLGGGTPYMSMPSSILDPWDHIGLGWSMD
1945	FNCDGPDTPPIIDQITEILEMCLQGDVSFESLDDLVLESLDCFSPEPSLDSMWCDVNDSSIVPEGPSEGFMNSEIVAAPQMDRHD
		1946	EAESWQPSIIGEPMAEIMDWPCPQEACCNCSEQVNMGSCCTSFNLDPVEGHSGPDIFLGLDNDEVEELFDWHVESPNIMPPSDGP
1947	GGGGSGSMPPTPEDQGPIWWNPFADYTDSDLPSGPMRVTSDDAILDFDALDYKPDPPCVDFQWYDMTPADASDWFDLLMLFDEEP
		1948	DAQWPPPTEDMDIHMESWVPENSFDEWHPVDWEYAAETSGMMAKDMLYSSPEDNGFGFLHGIMPSPITDWNMEFGIPEFVQTDQV
1949	DEIFNETLAMGLLDYLDDFDGDWPLSLPDSTPEVDQIFGCRMPLSLNDASELKDLCWTGPPNDEGDGPGSWGTIPINVDPYPMGS
		1950	CPGPLPHVADLDILGLMFALEEYAPCAECDNFSAAVTLVDSSGLWDSDQDPARDVPFDGSFLDWIMEDFDVWPPSIGHEEDSALL
1951	NWFASSIDLTAHWDLDLPSDDEEEEGAFNSGSTTEYLLDLPDDDDLLAITWGDPIGDELNLDASPPMTPSEPLDYFLSTFHGPLP
		1952	DMTSGQPLRLQNINHGTNEIADEWFPNIEPDCVWNLPCDDSPSPAWGMPTQLWSIWTCSEMHDSVDSFDMDINLFDPNAAVSPPD
1953	DGTPNDDLFANITQNLPWHHEEPPLNALFDTSATQDSSMAWDLWLDSPESQGCVVPLGGQPTGGLLPYMNIGIDCGDIFDLGGDG
		1954	HVMPNDPDMDNETICEHIQVYNDYQGYDHQYHNDPLMDTPGSSLQGFRDPGAQIEWVPMDYESFINWLDVPAWDPFDLCSPLWYD
1955	NMDEDPNTDNEWDNPWIGPPNNWHIWEDLQCSTPFQLSDYDKECEFNGMADNHLAAQICDDLDWAPFMQEQEMWTEPLQDEQGGS
		1956	DDILFNMYEPANPGSVIHNELGGHNPDLESNTEPDTPIEWTVNTGPLLNDCCEGYNLGNDMQHEMLNTVPIPWFEGCNVDDLPWV
1957	TSSGAAQSTPESLYDEVRVEVPEPHQDLPTNLTFTTFDGVLVCDLESIINSMLMPPMQLDANFQDDFVTDLWGWGDPDGPDEGAP
		1958	DFDDFQELLCADTLWPDLLEGGGDVGGQPHVCPMGPFADVPMTDWTSGLCGHSQLTCCDLSELLSQLGDSSDMGPFAPGDSCYWA
1959	GNAMENDATTCVTMCTDEGPIDNGPAMPADALDNPSDWSDFGTSSAITPDNYWSDLSFEETIFNRMAIEPLDWYDILVGLMNGPQ
		1960	DAIPPTEEEMRDTHNLPAPEEFSMDEQAAIWGSGTNVTMPACALNFPDWEDMMTHGSLFVADTMEVNEEELDCLLQVAEPLCYRH
1961	FPPEDPPGNACLDMAPHILGPNGCMPEGTPWPVPFPMSDETNQLGLEFCDLDIPIEMLFDWPHDIEFWWTEFPNELDIAWDPNMI
		1962	NDDYFCADWDMGNTAEEFFNIYEMFDLSHLPPIDSTAYPVPTSLPSGPSSSDGSAPSFGWIYGGTDMQVQEWTAGQPIGALNPTR
1963	LSDGGTMDLDHSSLLWLQDLPQATIDLPPTDFYDGLMGHSDWSTGDFSEGYTPHMHDELCLDDLLSMTTSESWGAVCPPPPAKRP
		1964	SCNWSREGRMTPSDYRHTYFDDQHALTPLAHLVSSAPAQFDCLDLIDWPDFGDLSDKPYGMGDSLDFEAIFGITGHEMDWNQLWA
1965	DDPPVGQWDPTFYDDTDAFLPPLDHLENWGFDIQENMYLFFQSMFASHDDLQTPSPNVYDQTPAAEWICQAASPQEEEGNNPYGK
		1966	HGKNTLMWPGHCGSTGIEPASLELPFDGTYNALPHIEPPHIDGWLPHSLPEDSAALDWMDILEGMDFTPTDWFNLNDGPTGTIWN
1967	PMADGGCSRHGCLWHWEDALLPGYDLGTLDEFLDPIDLGDLWKTIESGAGDFGQGDMMDPSDTWMQAHDSSQCTEHTCALDDPVG
		1968	PEGPTQPTHDDEYATSSAHGLEAHQDGAEMDPCMLDWMDYVYPSIDDWMCDWMHWFEAPDPAPNSPQMCMGTNCNLQWYPDHCDI
1969	ADDLCDIDDTNTKEDDDWSAFDLGVYPDWGWPDPEHIQMHFQPFHTNFIEDQHILDHVNNPWPLDNGAQGSAPQLPEMLWEAWYA
		1970	ADDATTWFDMLPGDLLDDFDLTEGWAAMPWAGPANLLGQLNLDDFDASDISMGAFFSESEDAATVESTGETSHPHTWLYLTTQQW
1971	QNPIDMALYNADFMDIFDTIPWQEGELFNLATDPGFESYQPEIIEQWTNVPTAEPLFDMCDLNHLAQQAQNTDNISQSSFPSPCQ
		1972	GADTLMVSHISLGQEGSHPGSEGCLCAAPSMDPEEALDFFPPEPLTSDGAFWDFDCLRCNDDTMMDFPVETMFTDALGCDIGDGT
1973	LDLSGLIPPDDNYQHCNCYCEPCKPMFCFTPQDPWGTDEDALIDSPWFASVAEDTDYYNGDNMFWDGFNPMEGVLDHILDFHQNE
		1974	DSIVGDSSHEQEGMAFRCPSLSHPWPEDMFDPSQYNDLDLPVIDFPDIELKSMERPPTMLWMHSEGYGPEAMYTHNSVEDWLMQV
1975	DYGGDALFPADVSLMDLYAAEPVDIDLTDTDCFDDFDLDLQLKTEDRHELLGMLDNAAYGWDGIPDRGFPDMSSDMTDWFATNTS
		1976	VAPATPQGPYNQHWDEVPDWPVFDHQVPCDFPVPTWPNCLTTLGELNNGLTDLDDLMNGSPNCMQDDTASPEEQEPDLYFYFALS
1977	PGHNPSNRDDFANFFNDLNACEAEISQHNWIVDWDADAWTEVLRTGPEEFDIPSAVWNMEWDDVLWWDCEDNLDSPWWNQPCDGS
		1978	ELNMLEMPQDQPGAPNHTDQCEFADPLAHSQIAIPLDWMGWFHPPPSPPYMDHLNPNDYTEPWDLAWDYFLPLNHMSVPEDGADD
1979	MRPSPGTLFDMDTLFNMAPEDDEHLYLDLGDLTASDTVNIFDGYLAGSTCLDEFMMDMLGFAALGDMDTDALGSPDGNFPEPVGH
		1980	LNLDDFCDWPPLGDQNENEDVCMCPEPPDAGCYLDMSSSDFLKGFDLDSLGGSMDDLIDIAAHWNTIQEGWSEAHSPELPSVPEP
1981	SCQLQEGAEQWRYHTENQMDCEHPVVTHEFDPIFVNPEFPSQDTRLSHEEDLGDPMYMPPNLDMFFYAWDFDYAPPTEWMTDGWW
		1982	YDVNESWTELTTFWDEVSEILLAPSGQSHADAHEEFHPLFQADGPAETPQPVPCVDEEWVWLHCNYPMAWFEVGPPQPEAGNAMD
1983	DTDYFDAMSWFDNILAQLPQHGPHLPEHAYVAPPAFDPVMAPRRGWFCEDLLASPGLSGEDLATIMEANESVFPWEGLWCNTTDM
		1984	TIPQYGPNIDLTCDTSCGELLPPSDALAPVQGFEVVSMIEGDIIDELLWETDKLSSLEGPTPLADPWVWTDNDELRELMGARNQW
1985	DAQACGVTEETLETVTDLDFPEEGSVISPPFEFTPAEHTTAPLGLWFSAPMPAPELAYLYSDVALGMVNMDIDFEPWHYAGQELP
		1986	YDPGLYHGFPPPADETQWMDHIFDNSIPPDWWLTAEAAPSAPSSHDLLASGSLVPSNDRPQGDPAVWASFQCWLGPDFGGNPQMD
1987	YEERLEVKQETMPVDSDGPACELWIDFDFDEFDTGLALLNGDAIDGLFSSDVTPLLRDYNTDAEQTKHDWCLNEEINVEPWGPAP
		1988	WDDMMTSTPEERLLWSCMDPLAIPLLGAPDQDTTQEMLAPYPMTNSQPMSTGDAVTAPDELETLIRHWCALEDFDLGLPDPLSSG
1989	TMNQARDNIAWSCASPESEVLVPGDLVQHPCPWITPDLSDIALYDPITFDESFDPYFIDAWYFSQDDGDVGTMFIMGDDIEHMNE
		1990	NACTWHPEMDQLCSQLWTYDDVYFPSFDNTSDQGMELQDAMLDPAHIQWIKEMDQLLVESDYEVAMDLQDDFPSFGECNDFGDSE
1991	QQDLVIPTDWLMPDYILCNEPDDGLDELLGMDYTNIDHLLTPELRDLDIPLVPWGNGDPQVHEFLERSYAHFGFDGMFGDADFDG
		1992	VDTASDMFNLCKQPADNDLWTPYCWDHMDTAPPASNAHPAPTEFSQFNEDDDMLCDLFIAGTSQAGFDLDDWMSMYSGITCREPV
1993	PFDIFQEVNPHPCPPSILMQPDPAWEEENQNDIIWFSGDQIDFPDMMNWSDPDVPEGEFHDFPPLTSNMYPEPLSWAAPPPELSE
		1994	DDIWWPMTHNWDDTFQGLLEYEASIDFDTSFPPMPSDSEWPLPDVMVDPIAWEPLGKLWNGMFTDTPEDGAESAAEEPKDEAECG
1995	STCHPCHNGWTIMEPGNMDTQESEADEWGFACGPLWGSSGISLDSDWLAANNMDQNDLGSDFAYYMEAESMNLADGSGATGPIWE
		1996	EPSKPMDTDGDAEHHCTVVEVPAFWGADPAGAQLTFDLWPESLMNMCSEDFDVLQPQGAGMIPLDGWGFNEMFQDYIGRSHQGSY
1997	CEDYLSTLVPPGRPDEHGPSSRGFLPQFDMNLDPGFDFDLGLDMALDDIDRLLCFIGREMPFQTVTQSGSAECNQGIPQQATHDV
		1998	EAAQMSEAAQWWEDLEPLPLPLDYLTYETFDMCQGTYQWIATPQEPQYNEQIPFEVHIDRHQPFKEFYWPEPMASDDTCDQGDGP
1999	FVMDDGDAFDFDSIPGDDAQLPPLSSDELVICKLDMLGSDTLTAEMLDKLHPGGVDTESNDSDVWFSLGDLPDLGGWCSPCPMTF
		2000	PDDIYILVPSVSNSPEMIECPLFPDDHQNLLQSHIDPLLATGSMLDMSQEEGLRNDAMAMFMNYLDHADWGLMFEHAPDSQESQA
2001	PTPGDHFEGIYDDLFQGLAENEYVFDFPEPVERPERMNSNDDIIDHLSSADDFPLLWLSPHPGGGDDGGKYPGQGYAPAGHDWTP
		2002	FDNAIPQEPHWWEGMEEGSLESFEWEGPNTFGGHGSFGATSTDPLLWLPQLNDVSSVLCETAEPHESFMNYLGEEWSAGRAAFEG
2003	TDLFGILADVEGGLDILPSQLWPTTPINDCPPLFMHDMTPNMTPINETLEQPLETWDVENCMQRWHHMPEREWLDYEFRMCGDMQ
		2004	SIGDPPPGAHAPVWLHEPYDHDCNAPEDPWEEDVSQTTFDDFLELLLDSSPHMYFPPIYFMNEELVAEPGNGQPGDGACPPYGGL
2005	DPLEFSELAMGPKDADCYELYNDWIEAHCATDPPPSMQPEGQLWDVWGLDPPFTVDPLFAEQVQLEPWTLMHPGNVDPLCEEDWG
		2006	SPHGTAMDESIEGLTELPEGCNPCFCCQPLPPPSAFGPTFSTKLWQFASDPNLDAHMSGLPAQEEWYNDWILQPDFDLTLQGWDA
2007	DPTDLDMLFYDIFGPPPSNMFVGSCERSDSEALLSIPDMMDITPLGASDDALGFGWGLDEYADPQPSGAGLYKLEGETSPTSVPP
		2008	EECELGTADALLDFDITMWDTEEVFDRVLDMIDQDDQSLWDLFDVEPDDFEPFDLDKHIGGGMTGLDLSMNEAHSELSMLDMLYS
2009	VPAVHPWVPPMLLHDGVIPNDAGPDFGSDILYPSTPEQDETMWLEDWNFWECLPLISELFAMPLEIEQAQSMPADAGTNVYGDLN
		2010	TWGAAPKPGMQELWCGLCEGEEGLGQLPDGFTTSEWPPATMEQQTCLDPSMTWGGDIFFDNNMLGPASEWQALLEEYVFNFECDQ
2011	GFPLNDIWASSYNPGEEFFPIVDEEALAHLLEANNFDADWDKLGEHLSDMPNDPFHDPGEMPEIGAFDLFNPESSGGDGEGLSGS
		2012	LSDDIPWSWINFDNFDVVPPWMMSSWDTDAMLDLAATALQGPGMSAGTDTPPPTPRPQWHNDLWGADPEAELVFLPDATEFGNQS
2013	TPEPFGQPRWTDQMQDIQAIESITDYSVDNLYPPSFLLPTLAEEIYDLDDNAPPDNLVNPGMYLEPLNDAFCPYNDFDLSTFWLA
		2014	DAPDPPLCVSYNINAHGSTGQILSKRNEELMDDPVQDPEFDATLLLADEPDNQPFLTMLFMNDPIDFWFEEMCMDAWGCDGGLNH
2015	IATHDLWTRAPEQFDLWDYNQSDYDTEQAFLGYENPTLSYDILTPWMATQPAIHDGQCEGASPTMIDEEWTLAPPDHSHNDCRWR
		2016	TDLDDLMYSPSLSDENTDWFGANNMGKDWTQSEIEGLLDLPDDWLAPAMLPDLKVHMSPGPDWGTPDDGQKGPPSTDHSLMDTCG
2017	GDGQPAPAMAKPMPLDLGDTISAAEAGASHGDAPACPGFQATAELDFDVLGHLDDTLIYAKMFQGELLGEIGDIDVLALLDQGLQ
		2018	LMDDPWDLFNNLDELFTDKEHPAVCELGLPPPDIGQTAWPMGTPRNPHDGVSTYYSMVGPGLEIEAFFDEIPNTSDAFLNDCWCF
2019	AGDIAWQDATADESDYGGNCFDMLNVNPEFFQPDPWCVSDSEFWQFWDLPPWVNDDDIQDLMRNNMMILGEGLHDADGRSEMDVQ
		2020	TQTGQASCTGTWNSVEDIWPEEEIEGPSTPHSSHYADNRFAEGLAGSNAMADTCIVSVGSGYGFDTIEELYWGLDLFSDQDYDAA
2021	EGANDCTCAPGCGQPSRYSPFAPEHAYQECELPSFPTLDDYDWMSIMSPPTHLDLQGCLMAMLEWDNFSDLPTQYQQWEWHDMIE
		2022	EVQDPHTPPDCFFGWPTVPNIDEYSWEWESNGENASLWHELMEHSDSPRPTLGMGTPHTFHIFPLDEFMYDTGIQDMQTLPPFDF
2023	VVDDIISTTNRPWWMDHEETEHNGEWNLPEGPNPPTPSPWLHSEENSSRPMEQPRVTWALDDLVMTNDMWAPCIGLTTHWDWGGI
		2024	EGPVEPTWSLTCSEHECSDDTTEQCDAQVWFEDPREFSASFNEMPLPQFAYESWWEEMNHNDDPIADIHLIWPWGDMWWEGLSDQ
2025	WCNYSATGASGSGQNVECEYNEHLYEITAEQHAQPNPWPTGPTGQELPCTLWDDSGWFQDVMFDTFWDMTLDDLLQPVMPSWFSG
		2026	KVAPIHQMFTYGSVTSSPVNDPYIETEFDSDWMEPMRTFILHNTDMNCLPNPEDTAAAMEQPEDWIMDTWFQNWLNGPGNGLPTN
2027	ATLHSPAPPSMWVQGESEGHDPEHEFTLHADDLSRFDGGSILGSIIDELMDMDVFDGPAKSTPPNDWEWMAWGPSFTEWQSHLNF
		2028	GDLDDLPDENRWSEFQGLLETLDDFQFPQPSEPWHSTPAESPFVEDPYDLEGDTPYHDVGECHWNDLRIMWDICLFEELGHMTSD
2029	WGESSHTTLIDLGYQDLPPEDEYQPWHEFPIVDFGEQDTPWDWQKWDCDIDTSNACSMGALGTSCWSDAWEFWEELDLTTPWPED
		2030	APPIDGSSTMPAGLEDFISMPCSPGVLDPFFSYTANRTSGEVTGDESLEFELLPIAIEQIYCQEDWPDPFSQYAESDTPSQFWAF
2031	VGLMDTTTAPDLGAVFYDFNADDYPVQPMCHMVDNLAQADMAELKWWTFSTGAALDSIMDQPDWSQASLDPPETWAEFDFSFDLD
		2032	GVPGGDSTQGQITMDADPQEYQHTNSHNYGGRLAPAQIDPSATTHDWPVIDDIWYEPALRLLPLDWFGEDPWVVGHDMQMDTLPL
2033	PYDDLSPCDGILPFDPMGMENDNTLGEPWPWSLSERPSEICLWVNDHVPGTLQDLVYAENIDNMSFQDLDWMDLHSPWTAILGDE
		2034	PYPIVGPGSPPGLEGVHTSAQPDHWLSPLQDMPAVPTHSAVDTTIWEPEWSLPAFNHYAFYPEDSWEDWVDDWNIINFTMLETNF
2035	MAYDSPTVPLNFDEQLMEEWFYDPQLDLGPDTAEPPTPNGEPSILDIEDLDVYMPKDCPMEIALLDDFYLWDARLLEEGGGTPPP
		2036	SDSWLMEDPLSDMFDAFHDLLELDVPVSQLYGLGDLSPTLEHLESALSEAFTWDPSSLSDSGGGLGLWEGGMPEAPGELDCAGFH
2037	NDTDGGASHYAGGDIFTPTDVLLHDSNMHPMQPDDYAFMEIPTWMEDLGIDLYAELDAPGSPEPPHPPAPPAPCTIREYFEDVGC
		2038	ADTCVAVMNNMHLCNPPQPELQMSDTHLYPMDEPMPNIFSMNDIHEPLYEQFELPDIDDIVEIVCNALEAGGLHSEMPWPDTWWP
2039	ASGGTIFETSPMDIEFPMPAAHPWEHLGLYSAFEFWDGALPNPLDLDSLALGDHEATLSHGEDVGFCHLMKDDDIMTDPPNTVND
		2040	ENEESNEAVTYYESLSDIGDCLHPGRRLDNHEVYDAFPPHDPNYCYGVPCYEPSIQDLFENEMTLDCLMQFWTINPCDGDNIGDS
2041	PPVQHQAPEDFFIFESQCDPQEVTEYFDFWFPCEVAETVPHIGPHLESMMSQSPYTEHIDDQGGQDNFDANWAECMLCMLDGFAL
		2042	DMPIWCELDKFFDIDDCTPPVSQSAALNQMSQLSAPSPALESQGLAMTDMPLGCGELLDGEDFEAGHLDDFLDWVDLEMGAGNQF
2043	QEWASQSMPDTPEAQTPFLMEDLQYYFSADEIAADTVLYPSPMKDLDGTSLEPLPPADDGLESLIRLFTAGESMHLDEVTVQMWG
		2044	DMPGSSEFLEMIIDLPEEPWVGNACGWHDMDGPHQSDELPDWVESYLIDHQELATTGGCINPLPPWNMTTLDSAMWDLFTDDDFW
2045	EPATEGPSVPCLGPPPLFMDGLSSLGPMHLPPGSSTSGAESGPEILWESLKSDVSFESLLFQGPSMGGIFDLMSSITWSTWGEGE
		2046	VGPWMYGMGEIINNMPLDALQVDELFEGFTCDFDCQFPAAHTMLSSVLQAPETTAREEPTSWEENWPYGQASDPDPYVQATGQDS
2047	ETEPGPSFMTTIDTELEHTIPLGHSNGHTSAYGSTIAGLLDLPADNAIDELFMGMDLPGPEPPHHYHQWAELDGTDPPLMPWPHL
		2048	PAGAPSRCVCYSDWEPIILCDDILGLDALNKPPTWEGGSDLLDPFDLDMFGHELAQHDFLGGQDYFTGYDGGSCSVNDPPDPAIV
2049	PGMDMEPPPDIMPLTPMPPPFEHGDWCVPTDMTQCKTMALNRDSLDLPLTPCMTGELDGFFNDMEHGELECDQFLMDVDFYILGP
		2050	SHDDMQCEATPLEHLHTNIQFHYAFNQDFIEPNMTDITNYWEDGLYLADLGAHLFGEPEPAAEPCSDEGLGPAINNMYIFGLDEP
2051	HDSQWCSTCAQRNDDPPTLPPPVPPWELSEEQSWCNENLTPPELWGLNDIEDAFVTYDLGGLGAMDIEEQTFLNPTWEHFLLGGQ
		2052	DKGGEVQESTPSGAPLLHDPGDFSTDVPLDDEWMFPMMQLVPDMTLPLDDYSDAEIMDLLSCCGVGWPIEADNWTPDGTEFGEPW
2053	CIPQSIGSSVMDMLPPLSRLHDGGPVYDVGTADHMPDNVPGPEELGFTDWSWESMDNDQDGIWNVNHFPEPTTWSSPCWDLCYLD
		2054	APLRADCSADGMPPSFGLDDWDRSENNTLVTDCSSDGIIFGGTTLEEIDLDELTFWPAIGSMADDEAFNSMLYEWWANMMDSDDT
2055	RDDALFQNENWLHEYPMDVILGDLDCPFEPPTQEECFWQLITHALWQCQEDEPAPPPEFFAWDLPMHDNELAWDPLSQDIEDHNM
		2056	QPIEDIMLGMWDEPFQGWDLPPIYPTCVEPPPSWTPAPWHGPIYDELDLESQALSAAQGPPMLHELVNTEDFYIEGGTAFDMGTG
2057	YYNYWERGGASGLEDAMDHTLQGECMPCPDHDIPFDDPGPFWDLEWTACSDIEQIFWPEPMPLQEDDNLWPSLGNSHDCAQWGTD
		2058	GGTDDFELWALMEPILGSLFEDPYQFVPDTDMTMGLDLAALGIGDSLSPGETTHDEALGENLDMPPEISTQMFLWTVESPHNDFC
2059	DDFDHDFEMLNAEDMATDIEIVDNFFDTVDTTDFLYLGSPAWFDFLLDIYDPNVANRLPPCDFVTEEDTQPSAGGQGGPPDLGVF
		2060	GGTDDIPDAIPLTHIFSNLCFGVDDFDYSPPCPDNADIAEDVYNFEDLMSVIIADGWDDEDQQGEDSSPGFLGLGSTPYVDHFGG
2061	GTYADPSAEPSAPIRNNSPGISDANDHDLWEPSHECNPMGLPDQESIIMNCLFDYDQGGEDDIDSLPFEWFPPSVWATTDWWYVE
		2062	VHYPAPDEFESAMIDLDPLDAVLTWNPYGCETHSIEEIHPPGDEFDEFMEALGWSNHQWLPYNLLQEPVQPNDLDILGHPQDHVC
2063	GMLPYHDGELWWDLPLPEPQEPTPWDNAEWMEYMDIFPNLTQELEWPSDHFDWCMHGLSALDMFGLQLPESQWFSELCGDGSPNP
		2064	AMDAPDMSPVPQEWRPSHSTAASVNIDMIAPVDYNEQTTMSDRPWCDTLEDTFTFGLMDHWFTVGQVEPNLADWTQWTHWPDQLF
2065	RIYEHGHFSADYNTGTGISTDEHAFWCPDDSTFPLPEPTFDLTLLGADPTFSGLLGNSWPIQNASQDEVEWMEFLLNGMFDLDEG
		2066	CECPYENHETYLYESLWEASAIEATIPTREPTPDMAPPYDVLWGMMESQISLNLSGMCPIIDDAMFNIPHDEPVQFSLFGPQDPQ
2067	GPSTGLDYLLMITPSEVNPQICPDFFSPEIEGESSSNLPSMHMFNIASSMDESWAEFWINNLGEYPDDPCRQADDAYDENGAANE
		2068	WALDEGPLDHLGMYAMDAPHSWDLGTDALDDHVLDASNPPSWDDFVADIIGGSEGKCAPSSTPDSQNFLDWLIDYDSIFPRLGGH
2069	IPADDSTSKESYPDPYGQNNDDGDLLFGLLEPIDTCIFCEDNMLGLPPQMPVDPDLMGLIGASGNVPHDQYCDFGPIGPYFWECW
		2070	AGGGGPTLSPASIWELLSFDEPGDFPKDHPMTELPAGALLDTDNESIIAEDLMDEGLLSPDMPVEFDMNFFPTEWLTCLQALDFP
2071	TITDTVDDTPPTDNCWSEFMPCNYPCWDATRQNNSTNAVFWHEPLASDLASEDPFYLGPNDHPGMAQLQNEHEWEMGLWDYGNIY
		2072	EPDWNVCFVNDEPASESDLFRELMQAPWALSDLWHGMYTIQPSDDCVLFTTTEQPAGNPMEGVPSLYTTDPMQSFTDCQPVENPM
2073	KDNGLSAMGPLQCAPDIPPTLPNLELDIWEHWGEGVTGGLTLPDMGFPDPAIGPTGLEGTLPDFDDCIQMWSYLYECAEWMETMY
		2074	DGLDNHHWWNCLMNNPCTEHPTEFGDAHRPQYPYEPNIMVGSLDPVLDWDLEYQPGGQDLDNWMEEMYNDNSIARTEEGCMDATM
2075	AQVPYDFAWMADMYNTHPPGQLLQISFDTQESADHDSQPSTSHTSCEQFANMFFDLDWTAIPLPQCDVFTDTQMHEYTPQHNIDE
		2076	GEAMAWLCTILNDLVGPLEDFSEPFMLDDLGSPSANPDTAFSGWAMLNDSVAIAGGETGDVWAEYWSLPEDDGGPSQSESSKGCK
2077	LSPLDGCIPLYNDPRQCGPLFQPWNVWTDTTTVPRPIFEYDEQEEHEVWSLINPLAGDLNTCADNPFLNHDNFMSDFEETMRDLN
		2078	QWTDPPAQVEYAMQEIDLEACRFHPADMGHQFPNPYNAQFDSVLFRSEFANLPDWDLMGDNEPQPCNEYQYWVTHSDFHELQEEI
2079	DGEPDTTPTAYPESITCDQDWLQGLNWMEGGVDSGQPPTLSQSPPLDHDDWLFAALDVPLSVYAGFFGHIEPGEGFFYGTYGGED
		2080	CPGCYHPMPDWINKAMEVPTTPHTQHRDIQDGFTAVASEWPEVSNDYMSQFLEPLMCQDDYSQEDEFMTEFLHFNEWHQEATDST
2081	YNDDEGVLPPFTESVIDDIMGGQMGCLYMLTTPTPLYSPSPAPNDAPAEAGRCADTSLFLTQLQGDYWQEWMYPDEGPSGYALQP
		2082	AMCGTSMGIIPLMPTELAFMSEIEPWMQPVGLPGWEESPSPACSLPESPLVQPSPLLEFITQPIPGWESRQNPWDEFMDETGVDQ
2083	HFLNMSITGVPLPDPMSEYLPAFEPSRDHVWDLEGCTLDFLSDVTQDLKDLPDIGELMCGWFQDMPPMYFFGESTPEAWSPPHSG
		2084	NPAVRQRTHVIDWGANDFMHSAPSPCYDSDYFDCDDLSSPSLCDGHLPGDFPGLDDILENVLCQPIGEAPFEWDFMGVERPPFGW
2085	IDASPADFPIFVNDASPEPVDNCDPSQMEEWLWPIRQPCPERGEYMCFDVEDILHLPSDHDRMDIENLYYQFQDEHFDIMTYENL
		2086	KAQEHPPFDIPLDEFFTLYESWDPQSYDEAQICLAIHNPPWHEPTLSDSPQLDNDILSWSDDRGGVLDFGMPLDELGCGKPGDFM
2087	ASPTLTMDCDFWDIPTHPTISGFQNFPYPFLGDEEFEIPPIPLDSDESLQVSQLYLCDDGGTIQPPAQHLEDFLSTLEEHQDMFG
		2088	LILELYEDAMATQDQFIPGEASIGSPQEVADIAETDTVGIFDSDWLQPCGPMNGLNYFLGVLSSFETQYQNSNVPEENWWWSPMQ
2089	SIMSELSSFIWEDNWQGLPDLEGVFDCEANAFEPLVWGTLDMPEDVGMPLDDDFLTMDRMALLPDTRPGHGPGESGGGKDGGKNT
		2090	FVPTIMEMPSLGPSPSDQEWTHFEYQNMECIDTEPASWPGAGPSMSDEVPEFLLPPYHCDFFEWLEPAMRNWGFPVQMPSEHETE
2091	AMSTPDPTETPHEMPFDWIEETVVCLGKSSTDSESLDDFDLTPLGDMDHAGQLDDFACSLCSMDIAGWGGGSPVSFPTFNSLDSK
		2092	PDTECYTNSLDDLVPQPSTLEEYESLTPYIFIPENDEKNTDASGWEEPWQTPPGVELHIQGQGLEPTDDAIFGILDEPQFWDGPG
2093	LEDTPLPAYDLEQCMSIMDLWANEGGESCWTEPWNTGPLLSGNLLNEEPPPTLLVPYNTGHFHEEIMSRSCVEYVGPMEEGPSWM
		2094	DSPMPEMDVPTGMGNMPAPLLEEGPTHPMDTQLPGLFPHNPQGWSMTEDWFQGFIDKIGWESSCDSHADFWDEAHSLEMWMELFE
2095	HDDLPPYNHFEPALLGNPLFQGPSLADERTDWNNTGIPFWDCLFEQLETLGLLPYGPQPYSPELPYLSVQPEGHDQGGSLDAQLN
		2096	EVEGNTMPETPDQSPSGHITAGNVEDIPWPQEASDAVWDTPSDQVDDLGENMSTPEWAVDLIFPDLEVCPGEWWPASYTHQLWFG
2097	ALDFENALLMAAWAPGPNELGLDCSELPEPGCLPCDFIWGTEGDYQAMCSTRDAAYMGEEFFPWINQQLSMEDTMLPEDGGQGGA
		2098	GMEPLPLPMSMVDLSDAFHLPPLPMTDMPDQWDDLPPALHTDHQLSNVDATMPPTLDHILQNMPGEYYWEDIAYAAGENEFDLMN
2099	PEFLADFHIDSWTNEESHNWIEDWISDPFDRDWPIDPFVTSHLPTGGNSVQAANEANDNMAMLPLFLQDEDITTFEPELLMIYQI
		2100	PEQTQDTMSGCVSDHDIDEAIEGAGGAAPELSFLMGHHWGVPAEEWHPFSTNDPAPQHWAFNIMEAPMDMNYLDLYNLLDEWWFG
2101	EGMEPTPKRTIAEHCNSMLHCEQTTYQEADPTNETFHTDVMTSWDIPNNGFNPVESWISWDTDATWALPEAFLREEWELCLFGGS
		2102	VEDLLDDMWSSYLNMNPDILMGLEPPCVPPDPSADMESMTCALNADGGSLNDFMEILDTFCMDDTWVEAFTPAWGNCEFMAALGS
2103	DNNNDMPDPYAGHPRCPSPILGDLAPCNDDGCTHTQYPGPAGFNPLAPPPEDVLSSDMLNLFDDIPWCDYHFNMMIDHMLFFPPN
		2104	DDFFMIDDSSLGNVLNLFADFECDAFYDDILPPPSMYHPGTDTNLFDKLFNLCEDPNWEAVFEVFEEGGGNAGEWTGDNIGAPVQ
2105	TPDDDGDDPLFSNPFRMQDWPPDISVSTSIDQDLVDSLMCFQDMALPDLGDLESHELWTPESQEPPAPNEDFLRLGGELVLPALG
		2106	FDGLPFANEHTWPPAQQWEDLQSDDWNVPNEFYVSPIFPDMLGPSVQHCHDPSDPPGYPGMAEFPEESFAHFLLNDLDTVLEVLT
2107	PNYIELEEFFERMIDPMLPEWIYDGQIPQAMDIPDPMMGAQPTYDGHGFMDLDPCMVFQPWDGFQDVLDKLFCDNPEGETGVQSG
		2108	AEYEMPPHGVVEMLTDDIFEELSKYDSFDKEPLPEFMLPSMLSLKDLMDFDLDKDLPDSNNDEIWTAANDAILLPEVQPSGQQAT
2109	PCEGVWQSDGDTKDLSNSDVCWLTPEAWDVTFTMQESLPWHFLQEIGMDNPWVDIPMDDWAAIFPPMDQEFPDLSAPWPDQSPSD
		2110	QEITTDWINQWPQLNQIPFDDEMESHEFPPNDDMLCHLHGPAIPVGWPLQDSVFGSPNAQSNTPTMEEWWECWLNMLIDPEVHCN
2111	SEAMDVPDSVAHFDAAFPEVLQPLEDEEPDPFSTALDMFGCFSTLYDDQPKSLDDILAYQLLDMMDTEFYGLNGLGGAEIGAGGR
		2112	PEGGSSDVDYDGEAQGSHGSNVSPQGYPWSWEFAPETPNTLLPEAIFDDTPPATPMIHTSQEFSSFISWLFDNLQDGSGQAYMDP
2113	ASMEADPEQPLGGYEEDNAEFAPEPTHDTLSPAQYDGSKPCIMTADQPGSTSPLPFADDELEAILWYQPVEDELAVLLNWSDNGF
		2114	RQADMLDSFTASLAPDAMYVEPIDEEDASELLDFFSDDMYMLPMFEVELLDPGSEDLGQLFPQEWPGGYWGGGGGETDGRAPQFL
2115	QDLPDPTQLPMDDMNPVIPLLHGLDLGTQDEFLDHGDLDDLWKTLDCSLPVLDRVDHFFELEGQGQGGDMGGWGPQGGGREGGTG
		2116	AGGSEGADALASYGTLLSQLDPGDPPKLALWLDGLEIHDFDFELLSVDEPAQDDGCATTPMPQLWDSLFEPSNFVPCGTMEMDPS
2117	HGFTTQQMGDGSTTYTHNFHEDIAGFWDDFLPSEPFEIPPLLGVLSPEEQEPPWLGVDLFNIWSDECFLTPDVCADGSWGGFPGY
		2118	EPSHPQYLDEEAIDPLQDLGQDYPGPSCPLLYPGACPPMPPQPCINIEFNLPDINHEFSSAICEYFLDWMDNQYGWPGPDEHTPQ
2119	AEYEVDDMGVQLVPTGDNLLQSILQYWDQDDLTEQCADPDLGPTWDLNWLEFEWLIPDQILDPVNDVMAPSEPKQWPLSMPPDGI
		2120	GPWWHFYPNNDEEPWWPCCQECFLGQQNARADDPPPESVEHLIGHPFPLVDQLPPEDMPDMPIPEMGNIAYEDDIFADCAWYDPD
2121	TDDPGTDLNLGNLGDAQPGVGHELNEEHFVTYFECWTPVFSMGDQLEESLKADSAFESLWHPEEDHCYPPMMPDIEEIISPEAYL
		2122	DPAMTDSMDAMMAGFPDDRPLIDFDSIMDEAKFDSLFSFAALETIFQSEVQLGDWLMLGGGQESMAHPPSFNPFDWDWGSDTDPV
2123	SDAVDLDTQEAEIQYLLSPFLPPRVPEASWTAPDFPRINTSEDFIDTSELDPGSASTTMNDLYMLWEQPMPLYWEYLFNELEDPM
		2124	DVLHSMIELPPTLNWTPFPLAGVPVVEPMALDQLYSALDNLDGLGMELPDAMIPELESNSEAQEGYDPVDTGFEEGWEGFMYQWP
2125	PCWVCYQDPVWCPNAYESPSNHEDDGAELGIHEFMEPFTLMHSEPTEMEHNFYVLPEFDEPWEIASPEFNWMCEDIPGIADDVEH
		2126	PSTQPQLSVMTASHGSLADLYDLMVDYPVDSPTCKASMDHRKDAKPNTTEEATLDAAAYASLDMFDFELDGMFEQGSMWIMEDYA
2127	PVRDEDEPPGNCFAESMYVPQGFEFVSEEMWGSLISGLCREWDAPVAEHSPETTDNAFPGDAEFDLNNPNSLMYSILYDCDTNDP
		2128	IAGLMEHAEAPSQHRAVEQYDQSQDSLVGFDVDHQSAATCNMYLDYWMATLRGSPMQLDDIYPLFPGWEDWNPESFCIDFATLDP
2129	GWSNDESGFTGMDLIGKLLEESLTCDVQVESLIFPELAAMALGSLDENELAMEPLGPEGLNPLLATYTMEASPAGSESFYMETMP
		2130	PTSTTLDSTNIGGIITLPEAPGHYNPEPPMVDIYSTALSDLWNCLWSDLYSDMDTQPDLNLSYTPADTWNPPLDGGNQGGAGDDD
2131	KAAYQDNGPSPCTDFVNDWCISPELLADIHDFGWQWDHLPKFDPMTTDDLLNFNDPISTEHFKHPHMPSLEDPLPEETQAAPGSP
		2132	ICEETPSMISPLSEAWDDFLGGGSMSLPGGGFGGGHNEWCLLDHLSDQGILLYDLGPCGSGDNTPLDNDGTDIIQLLSSIMGQEP
2133	PGENNTLDACDNDINLAPTGACEFSPPLPCWGLPYTLSNEQHEDIICWEEGLGNYGNELEEELDLLGNAWQGMLMEQPAEPGISG
		2134	DACCDSWLMFDCGDMSPGCPPEHAAIMADTPLQMQSATDLELGLGLSTEDWMGSLNLDLLNMLLDSDGGEFTYFPDFLGGLGWAG
2135	ALTGEPMIDDMCGMITADELYYTPNPAPPVNLLDTMLSGGLEDDVESLILNLFFDSAMHDAWTDSMLGPLESGLAGAPSQSHEEQ
		2136	HHMGSSTETLVRPIASSPAGTEYVHDEPEPVYMTPYGPPDSWTPMDSQNFFDHGMQELLYEDLQAMVESWWKPPIMDIFGDEGGW
2137	SDTDWTADNLECFPSLDLDSDQMAELLSLGHAGNNQQLCWFELDMLVSDSPDPGGAFPGDSDGSNDSPLDMLGYAGPLGNTLHLE
		2138	EPDHENGNCFKAWEAAHKWMYPFTGAWDGNYFWCQALPAQMEDLIMPNDPNVEDHGEVASEESYPSFDITQDCWDLFDNPLMTDD
2139	PGLSESSPSAWKGVPGYFTDGIGDPFRGPSMEQHANPHTQPGPTEGGDTPYDPPAGDHDFWMLLSGIDGPEIWPNVLSQIIEHDQ
		2140	EFAWQLLQPVGVEPSWCTLSQLDLPDVDAHLEQATSNLFSQPYMHDFDPTQDDFSTINELPADAASQSDDPEPAWMMFDLDTTWP
2141	LCGSPALQINDSFSTSGMFQEATWLDNDLAMCPYTPGPHLQDLLGESSDLPDCEVDLLISNELHEECLWEGLMPDNSMIMPGIGL
		2142	TAANVAQPDHTPHDTAECSPRFALTPAFDANFDMFDWINMNDSQFDSAIPEAFDYLTTLLDYIPMINMEVAPPDMEHIPFTWDAM
2143	CPDEMVPMAEDFFQPPDWLHELDYDWVCEPMEEFNEHLWMDWHIIPDDLLAPFSALPDSFMQGASGCSDDIQDESTQEDPSDEDP
		2144	WETMPGPGAAYEEMIVPKWCVTPWDDDDIQELLCDDDPFGMPSLDDLYDLEVTFPEDIPHGKYVTDVFSDDEFHQHLAFPDPMVL
2145	GSSGGHLDICPELWEWHNTLGEAAPCFYPDEDDPVNGIPPQLDLDYDLWLKFEHLFEGMAPQDSVSHPDISFSWDSCPEGLPPIF
		2146	DPGGQAVQTADTFDPYLIDYMHGCDTPWQADEFTGREWDPMDMLIFLDDLQLDLGLLYDLDDTAMAAFMNQEAGEWLGTGGAGDP
2147	SSDTCLQFWEGLLSMNDFTQPLPFPSYDMLLPPAEEMSLPMTDTCLTPEVVPGVPEMDHKDALAMLHCVNLDDFLFGLAPPPGSK
		2148	IVHGVGEDLMDFLEDPFVDELCDNDWPPQPWSWAISDAHYMTMPRDVACPWMEEENLDMCADYIYMMDSPHNYDLEFPLPDENQQ
2149	EDLGVQGTDMILPNIWTVAPNHPQPARDSDLPPTTLESYAGDSHSLSQGLQGSNYILDDLLKELAQQFDEYMGFDLLPCNAWDLP
		2150	TGYPPVAGPNFSAYLGFDLGCCPHHPVNFEDVHTADAESSEIILGDSLLDHPMFEPVDWNSACYEDFFDICLQNEDLDTMIMTEQ
2151	DDGNSLFWCNVRTDLGPCVANDEIIPCEAATCVYNPEFSFDLDQAAEQIWRSEQLDLSPPTQTEPNDMNWEDMGMDFEHVEKCFC
		2152	SASGSMLEGLGGTCQPYDYTVVPEYTLDADDAFFPPGPALESSLMEMNWPPDTWLWDMHGDFFDIGLNDDQLQGVLQDWIAFFHE
2153	TNPMYQELWDFEWFHVHNSDNITPEPHGVNDQPTISTGIFTPIEELAFEWLDHEPMAQDPCACPCDFTQPDHDQSLVPMWTALND
		2154	PGGFRQILFENDHDECDPIVHEVSPVSHWEVYNPYPWPPLESYSDWAMQQYDVGGQPSNNPESNFDQIWAHLEEEYFSGMFTMQM
2155	LDSTEPKDTGAPHPGTAGCEFHPLELLNENNPEEDQPLIETWLAGSPLRLEPPQWDAGAWEFKEWVPADADMDTMGMDQIYTMNC
		2156	AVAPLSDHTNLCAAMSPINIPFGYALGTLDEFVSPPTSVSHMGAIDDVFQSLFELLDGAGTESWDVFSPISPTDDGLWMFSTVGE
2157	NDPTITGPEPPNQEHGHGDMTNGGCEDADTCYKDPLQEDSMVPPIYTWSAEQAELHWEDFDGPFGIWGMNWDTILVDEIWGDDFR
		2158	GFPAVLAPPTDLGNLDELTLLNTLASIGYSGELDDPPLDALGDGDSPDVDSLQASIQELFHPQEQPVETQEMSWFDDQYAPTTLK
2159	LSDFDFALSMDPWNPDTTSLEPEEGTQDTAEGISDAGSPPVEDILELISRDTSPHCTGSNDAIDMFFSTLTEWEMWDGILPVIPG
		2160	APPFTRNMSDTVHDYSGGAPIYEWDHTQEQEAQEPIDLGEPHEWHDYEPSMLWYQYWPGMDFHDIVGPQEDDEWLGLDIFESTLL
2161	TGGLATTTPDFTINLDGDWFPVEAFVSADRLDSPSLFSGALSPEAMPICPDLLDELMLEGADVWMQDCGQIDSFTLFDDKVSCFM
		2162	YGEMVNGFGDFADACPCDDLMGPTYVTDHPLPPGWEQRVDLLPEDWGTDTPPATPSSEMPMPFSDNDPDMTLEQLWGIFSDIIMG
2163	VTPLGSSPWYGDGNHLEEDFLKTNVTQPVEDEWYVVDCDVGPDLLGLETQALEPAMDLWDMGTLLDNFMLGGPEPTADICIIDQV
		2164	EMSMEPMDASDRPLFSGLEITNMCTMSNEHLYWSDALESAHDANLINICDDLTITPNAAQDGEWDPWYDQVWQDGNIRMFDWMNV
2165	DSSHSGHGGWGGVDALGDFDEPPITSVDSILWWVNDTMQTIFPEAAICDTDIPDPGLLWPMPMPSPPPPDWEFEMDHLESMNISQ
		2166	NLGYGGPPEDCMYEEIAGLEDDLWTNFTNWEPVTPVDLSDLNNLLWAPPYTEDALLMDFMSLTPGGMDGLANWLLGLDPPNSAVP
2167	DTETRDTSREWPSGIITQEFTAAQPEVPSVHSNCDNSPYEDMGMGDSEHTPFEFDNEWALDHHDWGDLDVNPYNFCDFFAPCTDP
		2168	SEMVSDDSSATEEHGQEIPLEIDDLYEALGQPVIAPLDPWTMCGEELLWDLGDLAELLDPGECYQHKGGDGGGQDMGPVPWFMIA
2169	VTVTNPPGAEMMDSNPDIWDLEVPQIDDLSEILDEMLTDDLWDTIWSDIDTEDVCNGGWTLCQPLEYPNYAGYGLSQDTGDGWPG
		2170	PQDILSVLPGIDDLFQLLLETEYVFDSTHFEDANNEMDLAAASAPEGQAVMPSPEQEPVLSPSDLFAEHELPTYFQGTINWYGKG
2171	APPKGVIDGEQSAEDAAWIDWFPLPFSLHPVTDHCFGEWDIDDWEEPLPMVQPEQDQLWKHAAAESWWENTNVDWALFQPGYTGN
		2172	GEDGEAGITMEGCDLLSGPTLGDDNPYSERDFDLFWMTADWDMQDDSMLTPEIISMCLPIGPHLEMGQLEGTSDEPHIFDVPTGL
2173	VHFMEELVPDWPTWQDNGPFFLIPHVLDTNLFPPSHNEPSAEDELLDLDNPAKLFPDVDFPQFVPQPFTYTWPQELEDLLTYDHI
		2174	DSPCNLVGSPNMDDNPLIDLLQGYDLMQDDEFLDHGALDDLWATILSDVYPWDEPDRGLPGENMGGTGGLQTFATSLPTGASGAF
2175	CESPQIQPGDAQMGSPSVWHDCTVTEEWSTIPYVDAMIMQDITQSHMDVIAPPPPLAAHPSIWGEIADGAPDWMVAAWDEFTNYL
		2176	MPEAKPHTSAILPSWPMCPCEVHSLVEDQRQEGPPMTPGVLQQIENLDSAPGLFNLDNWFTEFDLFRLDNEVYEFLGILPQEEMY
2177	PMPLEPGMPGDFEGPPHPVDFEPSPQRCSPNPPQYLYLDLPDDDTYLLPDLGNLFETDDIQLMDMTPTPMWLDYLDIDGMSSVWR
		2178	PGYEHNDNQGGGPDPCASAYGEGEHVECQVVREALKPCAWSMAETTNIYQPPSNFDDLPMNWLAPLDYGTLHMWDDDQMDHWWDF
2179	PATVDTSYPFGPTEDMAPALYEAITLSDEPGDSPTPTNDGSECAPPAWDQDNLPWTLDFFLNHKMYWDHMIFNQDDQEVWDCDLQ
		2180	DDCGANSDIDSQYTAEEFFNYSEWEALNMLLERCNFDAFWDLGTENLSDMFSLLGTEALGPHGGLMDGGGEGMGLGGGGSGGGAL
2181	GCETDVAELNANDGPKPYPPEDEYNCDTPIMYGLTTSFHDHTTLTQAQPPAQHDDPAAMEFMFDNFNDFMNSYIDTWTSSDIAIC
		2182	GGPVQSQSADMWWDTLFPDVPMEDFEPEATEYTHGQVATMMHEPCTLDPYKDIMSPDPDAAFPIMLASFDETVGLNLQCMFPELP
2183	GGGGMPAMGDHLSDVGMDFDLDMLLSNGAELPRTSDCEFGLHDLLLPLLRESSSVYPLDLGTVQDLMPTRGSVDGGGFDYGGSDA
		2184	RAALDIEVPLGTWSGTTQLDMEECWDMIPDVDEFYTFEDFFQDFLDSLSPSPDANLCDSLAMFAGSENDEAMMDGESMQNEDRGL
2185	PPGEDCEVPASWTREQPVRASRGVGEHSSDVPSEVTNSISWDDIDELLNSWVSPWLSLSPTPYDFTNFNLEPEELDIDHFDWVYA
		2186	AMAFTEELMDNTLDDITNHVFPYPLTEDWLDMYVLGDMLNMIEMPDILAGDLQFIPHEFANPCGPQHDFQAPPMTHESARWQWDD
2187	DESDLSLAAPIPNILDPPSDVHPYDEAVMEGDVDAGDLSLHNPPDLDDLYSDEIQEAMWSNETWDTGSPLYPFDAALLDAIFQGS
		2188	CAAPEGVEFDIDYPWDNVLPNVHAMEVHQSFPLPPMDPFDLQDPNEEQVPPSMSWEPYELIEFWDSIANWQHESPGIMLTFENSG
2189	DGVQAQAFPDAKWLDCLWPLLDDWDWCHDPTISYGSPFAPSDMTELDLCQDDWTLMEFLAGVPDMSPPEASNIDSSGDKENMDWC
		2190	ADPDYSVDLLADQELFNEFNTMWGDFDDFWGWPCTPPGALAIPNSLPSALPDNDTHTMADFEADPYAISGLLSWCMGPGLQQAEY
2191	PPTQQNLEADEDIHNNFILDPEPPSPGVSDNWPYMPLPHSVLPPQDSPLTPYLNYITDGQLNMEMYAEFGPFSWTDLDECCGGQC
		2192	PMPLSGAADRDNDDAEEYFPISEEEALTQLLELNNWDAFLDLMTEMLSDMPMGGEEATTVQLHGGPMGPVPLLGADLFDHFGDDA
2193	LPGEQSAEDSHIWPRYMGPSPSLDSQPHPFDEDKSYTALFSHEPRIFDLPSLDTEWLADLGEMDCAAFMDELEDMGFTLGSGTLP
		2194	ETPDLFDVDMPLTPTDDVLVRWILDNDGEHDAPMPLWTPSSFSELDTSDWGIPSPFVGEYDEWQNYMASMTNNITGGGGDEKGEY
2195	MFDFEDWTPFDLDPGLPWSGATPTEVLPMVLHSEGQTPDLLSDWEQTLPDLGDPLALCNNTFDDFSDSTWLSIATGGWHMDPVLF
		2196	QYPLEPHSDDPTVDMSSGDTVPLDVEPLYEGTFWTPGPVLQDFLSWFETPNPAPNNAYQEQWGNWLEGFCENPPYSESFNHPQDG
2197	EPDQGNAPDIFMPSDHEENPEVHEYDIMALMQDFPTGVAAGPTISLPCGLHGACPCYLGWDDSAFNEEPLCMDLNLDDVMREAQY
		2198	TNHALYCDCVKEGTPYVQPQEHPRPPEAEDSWTDVFLLDDKGYADIYDLLDPGSEQFNSMDLPPSFELGEGTWDDEGGIGTTSHV
2199	ADDHFDHIIAEMAHTFVCNCNPNCPPENPNIFLPPTQEHHDLLDMWHNDSFECLSGLEMNPFVFGPLETPDYEWASFMPMDDNPD

In some embodiments, the polypeptide is conjugated to a heterologous endonuclease. In some embodiments, the heterologous endonuclease is or comprises a Cas protein. Any suitable Cas protein may be coupled to the polypeptide as described herein. In some embodiments, the Cas protein is a catalytically inactive Cas protein (e.g., lacks endonuclease activity). In some embodiments, the heterologous endonuclease comprises any of SEQ ID NOS 2222-2422, or a sequence at least 85% identical thereto. In some embodiments, the heterologous endonuclease comprises an amino acid sequence that has, or has at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or about 100% sequence identity to any of SEQ ID NOS: 2222-2422, or, optionally, has a percent sequence identity to any of SEQ ID NOS: 2222-2422 that is within a range defined by any two of the foregoing values (e.g., 80% -100%, 85% -95%, 90% -98%, etc.).

In some embodiments, the polypeptide is fused to a heterologous endonuclease (e.g., covalently linked directly or indirectly through a linker). The engineered gene effector polypeptide may be fused to the heterologous endonuclease in any suitable manner. In some embodiments, the polypeptide is fused to the C-terminus of the heterologous endonuclease. In some embodiments, the polypeptide is fused to the N-terminus of the heterologous endonuclease. In some embodiments, the polypeptide is fused to a position within the heterologous endonuclease. Accordingly, provided herein are fusion proteins comprising any one or more of the engineered gene effectors of the present disclosure (e.g., engineered gene effectors produced by computer-implemented methods of the present disclosure), and a heterologous endonuclease coupled to a polypeptide.

Also provided are polynucleotides comprising nucleotide sequences encoding any of the engineered gene effectors of the present disclosure or any fusion proteins (e.g., engineered gene effectors produced by computer-implemented methods of the present disclosure, or fusion proteins comprising the gene effectors). Vectors comprising the polynucleotides are also provided. Also provided are cells comprising the polynucleotides or vectors.

Provided herein are systems comprising any engineered gene effector of the present disclosure (e.g., an engineered gene effector produced by a computer-implemented method of the present disclosure), a heterologous endonuclease coupled to the engineered gene effector, and a guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell. In some embodiments, the heterologous endonuclease is or comprises a Cas protein, as described herein. Also provided are combinations of polynucleotides encoding the system, wherein the combinations of polynucleotides are configured to express in a cell a heterologous endonuclease coupled to an engineered gene effector, and a guide nucleic acid.

Also provided are methods of controlling a target gene in a cell, the methods comprising contacting the cell with a system of the present disclosure or a combination of the present disclosure. As disclosed herein, the cells may be contacted with the systems of the present disclosure or the combinations of the present disclosure using any suitable option. In some embodiments, the target gene is endogenous to the cell. In some embodiments, the contacting is performed in vitro or ex vivo.

Computer system

The present disclosure provides computer systems programmed to implement one or more methods of the present disclosure (e.g., computer-implemented methods). Fig. 20 illustrates a computer system 2001 that is programmed or otherwise configured.

Computer system 2001 may regulate various aspects of analysis, computation, and generation, and may be a user's electronic device or a computer system remotely located relative to the electronic device. The electronic device may be a mobile electronic device.

Computer system 2001 includes a central processing unit (CPU, also referred to herein as a "processor" and a "computer processor") 2005, which may be a single-core or multi-core processor, or multiple processors for parallel processing. Computer system 2001 also includes memory or storage unit 2010 (e.g., random access memory, read only memory, flash memory), electronic storage unit 2015 (e.g., hard disk), communication interface 2020 (e.g., network adapter) for communicating with one or more other systems, and peripheral devices 2025 (e.g., cache, other memory, data storage, and/or electronic display adapter). The memory 2010, the storage unit 2015, the interface 2020, and the peripheral device 2025 communicate with the CPU 2005 through a communication bus (solid line) (e.g., motherboard). The storage unit 2015 may be a data storage unit (or data repository) for storing data. Computer system 2001 may be operatively coupled to a computer network ("network") 2030 by way of communication interface 2020. The network 2030 may be the internet, the internet and/or an extranet, or an intranet and/or an extranet in communication with the internet.

In some embodiments, network 2030 is a telecommunications network and/or a data network. Network 2030 may contain one or more computer servers that may implement distributed computing, such as cloud computing. For example, one or more computer servers may implement cloud computing over a network 2030 ("cloud") to perform various aspects of the analysis, computation, and generation of the present disclosure, such as evaluating sequences of fixed length based on fitness functions, replacing random residues to generate mutant sequences, and collecting functional sequences accepted by fitness functions. Such cloud computing may be provided by cloud computing platforms, such as Amazon Web Services (AWS), microsoft Azure, google cloud platform, and IBM cloud. In some embodiments, network 2030 may implement a peer-to-peer network with computer system 2001, which may enable devices coupled to computer system 2001 to act as clients or servers.

The CPU 2005 may include one or more computer processors and/or one or more Graphics Processing Units (GPUs). The CPU 2005 may execute a sequence of machine-readable instructions, which may be embodied in a program or software. The instructions may be stored in a storage unit, such as memory 2010. Instructions may be sent to the CPU 2005, which may then program or otherwise configure the CPU 2005 to implement the methods of the present disclosure. Examples of operations performed by the CPU 2005 may include fetch, decode, execute, and write back.

The CPU 2005 may be part of a circuit, such as an integrated circuit. One or more other components of system 2001 may be included in the circuit. In some embodiments, the circuit is an Application Specific Integrated Circuit (ASIC).

The storage unit 2015 may store files such as drivers, libraries, and saved programs. The storage unit 2015 may store user data, such as user preferences and user programs. In some embodiments, computer system 2001 may include one or more additional data storage units external to computer system 2001, such as on a remote server in communication with computer system 2001 via an intranet or the internet.

Computer system 2001 can communicate with one or more remote computer systems over network 2030. For example, computer system 2001 may communicate with a user's remote computer system. Examples of remote computer systems include personal computers (e.g., portable PCs), tablet or tablet computers (e.g., apple iPad, samsung, or Galaxy Tab), telephones, smartphones (e.g., apple iPhone, android-enabled devices, or Blackberry), or personal digital assistants. A user may access computer system 2001 via network 2030.

The methods described herein may be implemented by machine (e.g., a computer processor) executable code stored on an electronic storage location (e.g., memory 2010 or electronic storage 2015) of computer system 2001. The machine executable code or machine readable code may be provided in software. During use, code may be executed by processor 2005. In some embodiments, code may be retrieved from storage unit 2015 and stored in memory 2010 for ready access by processor 2005. In some cases, the electronic storage unit 2015 may be eliminated and the machine-executable instructions stored in memory 2010.

The code may be pre-compiled and configured for use with a machine having a processor adapted to execute the code, or may be compiled at runtime. The code may be provided in a programming language that is selectable to enable execution of the code in a pre-compiled or compiled manner.

Embodiments of the systems and methods provided herein (e.g., computer system 2001) may be implemented in programming. Aspects of the technology may be considered "articles of manufacture" or "articles of manufacture," typically in the form of machine (or processor) executable code and/or associated data, which are carried or embodied on a type of machine readable medium. The machine executable code may be stored on an electronic storage unit such as a memory (e.g., read only memory, random access memory, flash memory) or hard disk. A "storage" medium may include any or all of the tangible memory of a computer, processor, etc., or their associated modules (e.g., various semiconductor memory, tape drive, or disk drive), which may provide non-transitory storage for software programming at any time. All or part of the software may sometimes communicate over the internet or various other telecommunications networks. For example, such communication may enable loading of software from one computer or processor to another computer or processor, such as from a management server or host computer to a computer platform of an application server. Thus, another type of medium that can carry software includes optical, electrical, and electromagnetic waves, such as those used across physical interfaces between local devices through wired and fiber-optic landline networks, and various air links. Physical elements carrying such waves (e.g., wired or wireless links, optical links, etc.) may also be considered to be media carrying software. As used herein, unless limited to a non-transitory, tangible "storage" medium, terms such as computer or machine "readable medium" refer to any medium that participates in providing instructions to a processor for execution.

Accordingly, a machine-readable medium (e.g., computer-executable code) may take many forms, including tangible storage media, carrier wave media, or physical transmission media. Non-volatile storage media includes, for example, optical or magnetic disks (e.g., any storage device in any computer, etc.), such as may be used to implement the databases shown in the figures. Volatile storage media include dynamic memory, such as the main memory of such a computer platform. Tangible transmission media include coaxial cables, copper wire and fiber optics, including the wires that comprise a bus within a computer system. Carrier wave transmission media can take the form of electrical or electromagnetic signals, or acoustic or light waves (such as those generated during Radio Frequency (RF) and Infrared (IR) data communications). Thus, common forms of computer-readable media include, for example, a floppy disk, a flexible disk, hard disk, magnetic tape, any other magnetic medium, a CD-ROM, DVD, or DVD-ROM, any other optical medium, punch cards and paper tape, any other physical storage medium with patterns of holes, RAM, ROM, PROM and EPROMs, FLASH-EPROMs, any other memory chip or cartridge, a carrier wave transporting data or instructions, a cable or link transporting such a carrier wave, or any other medium from which a computer can read programming code and/or data. Many of these forms of computer readable media may be involved in carrying one or more sequences of one or more instructions to a processor for execution.

The computer system 2001 may include an electronic display 2035 or be in communication with the electronic display 2035, the electronic display 2035 including a User Interface (UI) 2040. Examples of UIs include, but are not limited to, graphical User Interfaces (GUIs) and web-based user interfaces.

The methods and systems of the present disclosure may be implemented by one or more algorithms. The algorithm may be implemented by software when executed by the central processing unit 2005. For example, an algorithm may evaluate sequences with a fixed length based on fitness functions, replace random residues to generate mutated sequences, and collect functional sequences accepted by fitness functions.

Non-transitory computer readable storage medium

In some embodiments, the platforms, systems, media, and methods disclosed herein include one or more non-transitory computer-readable storage media encoded with a program comprising instructions executable by an operating system of an optionally networked computing device. In a further embodiment, the computer-readable storage medium is a tangible component of a computing device. In still further embodiments, the computer-readable storage medium is optionally removable from the computing device. In some embodiments, computer readable storage media include, by way of non-limiting example, CD-ROMs, DVDs, flash memory devices, solid state memory, magnetic disk drives, magnetic tape drives, optical disk drives, a distributed computing system comprising a cloud computing system and a server, and the like. In some cases, the programs and instructions are encoded on the medium permanently, substantially permanently, semi-permanently, or non-temporarily.

Computer program

In some embodiments, the platforms, systems, media, and methods disclosed herein include at least one computer program or use thereof. The computer program contains sequences of instructions that are executable by one or more processors of the CPU of the computing device, written to perform specific tasks. Computer readable instructions may be implemented as program modules, such as functions, objects, application Programming Interfaces (APIs), computing data structures, etc., that perform particular tasks or implement particular abstract data types. Based on the disclosure provided herein, one of ordinary skill in the art will recognize that computer programs may be written in various versions of various languages.

The functionality of the computer readable instructions may be combined or distributed as desired in various environments. In some implementations, the computer program includes a set of sequences of instructions. In some implementations, the computer program includes multiple sets of instruction sequences. In some embodiments, the computer program is provided from one location. In other embodiments, the computer program is provided from a plurality of locations. In various embodiments, the computer program includes one or more software modules. In various embodiments, the computer program comprises, in part or in whole, one or more web applications, one or more mobile applications, one or more stand-alone applications, one or more web browser plug-ins, extensions, add-in programs, or add-ons, or a combination thereof.

Web application program

In some implementations, the computer program includes a web application. Based on the disclosure provided herein, one of ordinary skill in the art will recognize that in various embodiments, web applications utilize one or more software frameworks and one or more database systems. In some embodiments, the web application is created on a software framework, such as Microsoft. In some embodiments, the web application utilizes one or more database systems including relational, non-relational, object-oriented, associative, XML, and document-oriented database systems, as non-limiting examples. In further embodiments, suitable relational database systems include Microsoft SQL SERVER, mySQL ^TM, and/or Oracle as non-limiting examples. Those skilled in the art will also recognize that in various embodiments, web applications are written in one or more versions of one or more languages. The web application may be written in one or more markup languages, presentation definition languages, client-side scripting languages, server-side coding languages, database query languages, or a combination thereof. In some embodiments, web applications are written in a markup language such as hypertext markup language (HTML), extensible hypertext markup language (XHTML), or extensible markup language (XML) to some extent. In some embodiments, the web application is written in a representation definition language (e.g., cascading Style Sheets (CSS)) to some extent. In some embodiments, the web application is written in a client-side scripting language, such as asynchronous JavaScript and XML (AJAX), flash ActionScript, javaScript, or Silverlight. In some embodiments, the web application is written in a server-side coded language such as ACTIVE SERVER PAGES (ASP), cold fusion, perl, java, javaServer Pages (JSP), hypertext preprocessor (PHP), pythonTM, ruby, tcl, smalltalk, webDNA, or Groovy to some extent. In some embodiments, web applications are written in a database query language (e.g., structured Query Language (SQL)) to some extent. In some embodiments, the web application integrates an enterprise server product, such as an IBM body Lotus Domino. In some implementations, the web application includes a media player element. In various further embodiments, the media player element utilizes one or more of a variety of suitable multimedia technologies, including, as non-limiting examples, adobe cube, HTML 5, apple cube, quickTime cube, microsoft, silverlight, java, and Unity cube.

Standalone applications

In some embodiments, the computer program comprises a stand-alone application that is a program that runs as a stand-alone computer process, rather than an add-on (e.g., not a plug-in) to an existing process. Those skilled in the art will recognize that stand-alone applications are typically compiled. A compiler is a computer program that converts source code written in a programming language into binary object code, such as assembly language or machine code. Suitable compiled programming languages include C, C ++, objective-C, COBOL, delphi, eiffel, javaTM, lisp, pythonTM, visual Basic, and VB. NET, or combinations thereof, as non-limiting examples. The execution of compilation is typically at least partially to create an executable program. In some implementations, the computer program includes one or more executable compiled applications.

Software module

In some embodiments, the platforms, systems, media, and methods disclosed herein include software modules, server modules, and/or database modules, or uses thereof. Based on the disclosure provided herein, software modules are created by techniques known to those of skill in the art using machines, software, and languages known in the art. The software modules disclosed herein are implemented in a variety of ways. In various embodiments, the software modules include files, code segments, programming objects, programming structures, distributed computing resources, cloud computing resources, or a combination thereof. In further various embodiments, the software module comprises a plurality of files, a plurality of code segments, a plurality of programming objects, a plurality of programming structures, a plurality of distributed computing resources, a plurality of cloud computing resources, or a combination thereof. In various embodiments, one or more software modules include, as non-limiting examples, a web application, a mobile application, a standalone application, and a distributed or cloud computing application. In some embodiments, the software module is in a computer program or application. In other embodiments, the software modules are in more than one computer program or application. In some embodiments, the software modules are hosted on one machine. In other embodiments, the software modules are hosted on more than one machine. In further embodiments, the software modules are hosted on a distributed computing platform, such as a cloud computing platform. In some embodiments, the software modules are hosted on one or more machines in one location. In other embodiments, the software modules are hosted on one or more machines in more than one location.

Database for storing data

In some embodiments, the systems, media, and methods disclosed herein include one or more databases or their uses. Based on the disclosure provided herein, one of ordinary skill in the art will recognize that many databases are suitable for storing and retrieving user information, genomic information, expression information, transcriptome information, and proteome information. In various embodiments, suitable databases include, as non-limiting examples, relational databases, non-relational databases, object-oriented databases, object databases, entity-relational model databases, associative databases, XML databases, document-oriented databases, and picture databases. Further non-limiting examples include SQL, postgreSQL, mySQL, oracle, DB, sybase, and/or MongoDB. In some embodiments, the database is internet-based. In a further embodiment, the database is web-based. In a further embodiment, the database is cloud computing based. In particular embodiments, the database is a distributed database. In other embodiments, the database is based on one or more local computer storage devices.

Additional embodiments

Systems and methods for gene regulation

Transcriptional and epigenetic regulatory factors can play a key role in modeling the chromatin microenvironment and corresponding gene expression during cell differentiation and homeostasis. Thus, natural or engineered transcriptional regulators constitute a powerful tool kit for controlling gene doses in future therapeutic applications. Robust and durable gene silencing by epigenetic memory, and robust but transient gene activation, respectively, can be achieved using polyprotein domain fusion, but long coding lengths can prevent their packaging into AAV and other vectors, and limit clinical applications. High throughput dCas modulator recruitment screening was performed to systematically query the relative transcriptional regulatory efficacy of tens of thousands of human, viral and archaeal peptide fragments in the opposite promoter environment, finding known and novel domains that have a strong propensity for activation of viral domains, repression of human domains, and background dependent dual activity features of archaeal domains. Sequence-based biochemical component analysis, combined with extensive validated testing of multiple target promoters in different chromatin contexts, reveals predictive biochemical scoring criteria for engineering functional improvement into minimal core activation domains. This procedure for modulator discovery and engineering resulted in ultra-compact transcriptional activators of human gene expression whose targeted upregulation levels exceeded the previous baseline activators in terms of magnitude, background-independent robustness and duration of action, albeit accounting for about 12% -20% of their protein-encoding payload size. When fused to the RNA-guided mini-dCas system for programmable recruitment, these ultra-compact transcriptional regulators are capable of achieving efficient and mitotically durable gene activation in different target environments with reduced payload sizes suitable for delivery and other therapeutic modalities by a single AAV.

Systems and methods for epigenomic editing

Epigenomic editing is an emerging therapeutic application new strategy by activating or silencing target gene expression. To increase the efficiency of epigenomic editing and achieve reduced payload sizes suitable for delivery by a single AAV, the CRISPR-Cas system is engineered to reduce its overall size while enhancing the function of the Ribonucleoprotein (RNP) complex. By semi-rational guided gRNA scaffold and Cas effector modification, a more compact RNP complex is obtained that exhibits improved epigenetic editing activity. The improved accuracy and efficiency of the epigenomic editing system was demonstrated when fused with an internally developed ultra-compact transcriptional regulator. To comprehensively characterize the PAM requirement of dCas protein, a novel mixed cell assay using synthetic target activation was developed to sensitively query the relaxed PAM spectrum of these effectors. In summary, a more compact RNP construct (with a Cas effect factor of 500 amino acids size complexed with a gRNA scaffold of about 100 nucleotides in length), and enhanced CRISPRa/CRISPRi efficiency is achieved when compared to the parental RNP.

Non-limiting embodiments of the present disclosure are further provided in the following numbered embodiments.

1. An engineered gene effector, the effector comprising a polypeptide comprising:

a first peptide of 75-110 (or 75-95) amino acids in length, wherein the first peptide comprises any one of SEQ ID NOS 3-100, or a sequence at least 85% identical thereto, and

A second peptide of 75-110 (or 75-95) amino acids in length and heterologous to the first peptide, wherein the second peptide comprises any one of SEQ ID NOs 3-100, or a sequence at least 85% identical thereto, optionally wherein the first peptide is different from the second peptide.

2. The engineered gene effector of embodiment 1, wherein the first peptide and/or the second peptide is 85 or 108 amino acids in length, optionally wherein the first peptide and the second peptide are each 85 or 108 amino acids in length.

3. The engineered gene effector of embodiments 1 or 2, wherein the first peptide comprises any one of SEQ ID NOs 3-100 with a mutation of 0-3 amino acid residues and/or the second peptide comprises any one of SEQ ID NOs 3-100 with a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

4. The engineered gene effector of embodiments 1 or 2, wherein the first peptide comprises any one of SEQ ID NOs 3-100 and/or the second peptide comprises any one of SEQ ID NOs 3-100.

5. The engineered gene effector of any one of the preceding embodiments, wherein the first peptide is located N-terminal to the second peptide, wherein any one of SEQ ID NOs 3-100 of the first peptide comprises SEQ ID NOs 3-100, and wherein any one of SEQ ID NOs 3-100 of the second peptide comprises SEQ ID NOs 3-100.

6. The engineered gene effector of embodiment 5, wherein the first peptide and the second peptide are arranged in pairs according to any one of the SEQ ID NOs of the first peptide and the second peptide listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

7. The engineered gene effector of any one of the preceding embodiments, wherein the first peptide and the second peptide are linked by a linker, optionally wherein the linker comprises any one or more of SEQ ID NOs 2211-2221, optionally wherein the linker comprises SEQ ID NO 2211.

8. The engineered gene effector of any one of the preceding embodiments, wherein the polypeptide comprises any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence at least 85% identical thereto.

9. The engineered gene effector of embodiment 7, wherein the polypeptide comprises any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451 having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

10. The engineered gene effector of any one of the preceding embodiments, wherein the polypeptide comprises any one of SEQ ID NOs 1085, 122, 1084, 653, 1099 and 1107, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

11. The engineered gene effector of any one of the preceding embodiments, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, optionally wherein the target gene is endogenous to the cell.

12. The engineered gene effector of embodiment 10, wherein the target gene is a silenced gene, optionally wherein the silenced gene is a methylated gene.

13. The engineered gene effector of embodiments 10 or 11, wherein the engineered gene effector is capable of increasing, or increasing by at least or about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 250%, 300%, 400%, 500% the expression level of the target gene, optionally wherein the engineered gene effector is capable of increasing the expression level of the target gene by a percentage within a range defined by any two of the foregoing values, e.g., 10% -100%, 100% -200%, 200% -400%, 250% -500%, 10% -50%, 50% -100%, etc.

14. The engineered gene effector of any one of the preceding embodiments, wherein the polypeptide is coupled to a heterologous endonuclease, optionally wherein the heterologous endonuclease is a Cas protein.

15. The engineered gene effector of embodiment 13, wherein the heterologous endonuclease has a length of, at most, or about 450, 460, 470, 480, 490, 500, 520, 540, 560, 580, 600, 620, 640, 660, 680, 700 amino acids, optionally wherein the length of the heterologous endonuclease is within a range defined by any two of the foregoing values, e.g., 450-700 amino acids, 480-600 amino acids, 500-530 amino acids, 500-600 amino acids, etc.

16. The engineered gene effector of embodiments 13 or 14, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

17. The engineered gene effector of any one of embodiments 13-15, wherein the polypeptide is fused to the heterologous endonuclease.

18. The engineered gene effector of embodiment 16, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

19. An engineered gene effector, the effector comprising a polypeptide comprising:

A first peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator, and

A second peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator, wherein the second peptide is heterologous to the first peptide, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene.

20. The engineered gene effector of any one of the preceding embodiments, wherein the first peptide and/or the second peptide has a beta factor of about 30 to about 65.

21. The engineered gene effector of any one of the preceding embodiments, wherein the first peptide and/or the second peptide is enriched in a negative electrostatic potential.

22. The engineered gene effector of any one of the preceding embodiments, wherein the first peptide and/or the second peptide has a negative net charge.

23. The engineered gene effector of any one of the preceding embodiments, wherein the engineered gene effector is capable of activating a target gene in a cell, wherein the level of target gene expression activated by the engineered gene effector lasts for a period of time that is, about or at least 9 days, 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, or longer, or optionally, the level of expression lasts for a period of time that is within a range defined by any two of the preceding values, e.g., 9-18 days, 9-14 days, 12-18 days, 14-16 days, etc.

24. The engineered gene effector of any one of the preceding embodiments, wherein the engineered gene effector is capable of activating a target gene in a cell, wherein the expression level of the target gene is increased by at least 0.1-fold, 0.2-fold, 0.3-fold, 0.4-fold, 0.5-fold, 0.6-fold, 0.7-fold, 0.8-fold, 0.9-fold, 1-fold, 1.5-fold, 2-fold, 2.5-fold, 3-fold, 5-fold, 10-fold, 20-fold, 30-fold, 40-fold, 50-fold or more, or optionally the expression level of the target gene is increased by a factor within a range defined by any two of the foregoing values, e.g., 0.1-50-fold, 0.5-10-fold, 1-40-fold, 2-30-fold, etc., as compared to a control.

25. A fusion protein, the protein comprising:

An engineered gene effector according to any one of the preceding embodiments, and

A heterologous endonuclease coupled to a polypeptide, optionally, wherein the heterologous endonuclease is a Cas protein.

26. The fusion protein of embodiment 24, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOS: 2222-2422, or a sequence at least 85% identical thereto.

27. The fusion protein of embodiment 24 or 25, wherein the polypeptide is fused to the heterologous endonuclease.

28. The fusion protein of embodiment 24, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

29. A polynucleotide comprising a nucleotide sequence encoding the engineered gene effector or fusion protein of any of the preceding embodiments.

30. A vector comprising the polynucleotide of embodiment 28.

31. A cell comprising the polynucleotide of embodiment 28 or the vector of embodiment 29.

32. A system, the system comprising:

the engineered gene effector of any one of embodiments 1-23;

Optionally, a heterologous endonuclease coupled to the polypeptide of the engineered gene effector, wherein the heterologous endonuclease is a Cas protein, and

A guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell.

33. The system of embodiment 31, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOS: 2222-2422, or a sequence at least 85% identical thereto.

34. The system of embodiment 31 or 32, wherein the polypeptide is fused to the heterologous endonuclease.

35. The system of embodiment 33, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

36. A combination of polynucleotides encoding the system of any one of embodiments 29-34, wherein the combination of polynucleotides is configured to express a heterologous endonuclease coupled to an engineered gene effector and a guide nucleic acid in a cell.

37. A kit comprising an engineered gene effector, fusion protein, combination, system, polynucleotide, vector, and/or cell of any of the preceding embodiments.

38. A method of controlling a target gene in a cell, the method comprising contacting the cell with the engineered gene effector of any one of embodiments 1-23, the fusion protein of any one of embodiments 24-27, the polynucleotide of embodiment 28, the vector of embodiment 29, the system of any one of embodiments 29-34, or the combination of polynucleotides of embodiment 33.

39. The method of embodiment 37, wherein the target gene is endogenous to the cell.

40. The method of embodiment 37 or 38, wherein the contacting is performed in vitro or ex vivo.

41. A computer-implemented method of generating a functional biological sequence, the method comprising:

(a) Providing an fitness function trained on a biological data set, the biological data set comprising functionally determined biological sequences having a fixed length;

(b) Providing in a computer a plurality of different sequences comprising a fixed length, each sequence being associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of the temperature gradient;

(c) By means of the computer, parallel in a plurality of different sequences:

(1) Selecting one or more random positions for introducing substitutions in one or more of said plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and

For each of the one or more sequences, evaluating a first fitness change resulting from introducing a replacement at one or more randomly selected locations, and accepting or rejecting the replacement based on the evaluated first fitness change, and optionally further based on a temperature associated with the sequence, and/or

(2) Selecting one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a successive temperature of the temperature gradient, optionally selecting up to 3 pairs of the plurality of different sequences, optionally selecting 1 pair of the plurality of different sequences, and

For each selected pair:

Selecting one or more domains for exchange between sequences of selected pairs, and

Evaluating the difference in fitness of the sequences of the selected pair due to the exchange of one or more domains, and

Accepting or rejecting one or more domain exchanges between the selected pairs based on the fitness differences and the temperatures associated with each sequence of the selected pairs, and

(D) Iteratively performing (c), wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domains of a previous iteration are swapped into the plurality of different sequences,

Thereby producing one or more functional sequences having fitness at or above a desired fitness threshold.

42. The method of embodiment 40, comprising accepting, at (c) (1), a substitution at one or more randomly selected positions when the fitness of the sequence after the substitution is introduced is greater than the fitness of the sequence before the substitution is introduced.

43. The method of embodiment 40 or 41, comprising accepting or rejecting, at (c) (1), a substitution at one or more randomly selected locations based on a probability weighted by a ratio of fitness of the sequence after introducing the substitution to fitness of the sequence before introducing the substitution.

44. The method of any one of embodiments 40-42, comprising, at (c) (1), accepting or rejecting a replacement at one or more randomly selected locations based on Boltzmann Metropolis-hastins acceptance criterion r _mh.

45. The method of any of embodiments 40-43, wherein the one or more randomly selected locations are selected uniformly across the fixed length.

46. The method of any one of embodiments 40-44, comprising at (c) (2), accepting an exchange of the selected domain between the selected pair when the fitness of the sequence associated with a lower of the consecutive temperatures after the exchange is greater than the fitness of the sequence associated with a higher of the consecutive temperatures after the exchange, optionally wherein the selected domain comprises the complete sequence of the selected pair.

47. The method of any one of embodiments 40-45, comprising, at (c) (2), accepting an exchange of the selected domain between the selected pairs based on a probability inversely proportional to a difference between temperatures associated with each sequence of the pairs, and a ratio of fitness of exchanged sequence pairs, optionally wherein the selected domain comprises the complete sequence of the selected pair.

48. The method of any one of embodiments 40-46, comprising at (c) (2), accepting or rejecting an exchange of selected domains between the pairs based on parallel tempering criteria r _re, optionally wherein the selected domains comprise the complete sequence of the selected pair.

49. The method of any one of embodiments 40-47, wherein (c) comprises:

(3) Selecting a crossover site between one or more pairs of said plurality of different sequences, and

For each of the one or more pairs in which a crossover site is selected, a second fitness change for each sequence of the selected pair resulting from crossover at the crossover site is evaluated, and crossover at the selected crossover site is accepted or rejected based on the second fitness change and a temperature associated with each sequence of the selected pair.

50. The method of embodiment 48 comprising accepting or rejecting crossover at the selected crossover site based on a probability weighted by a ratio of second fitness changes for each sequence of the selected pair.

51. The method of any of embodiments 40-49, wherein at least one of the one or more functional sequences produced has a fitness based on a fitness function that is greater than a fitness of each of the plurality of different sequences prior to any iteration of (c).

52. The method of any of embodiments 40-50, wherein the desired fitness threshold is based on fitness associated with a corresponding sequence of the plurality of different sequences in (b), optionally wherein the desired fitness threshold is based on a maximum fitness among the plurality of different sequences.

53. The method of any one of embodiments 40-51, wherein the plurality of different sequences in (b) comprises a plurality of different, naturally occurring sequences.

54. A computer-implemented method of generating a functional biological sequence, the method comprising:

(a) Evaluating, by a computer, sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functionally determined biological sequences having the fixed length;

(b) Replacing, by the computer, one or more random residues in the sequence to generate a mutated sequence;

(c) Evaluating, by the computer, the mutant sequence based on the fitness function, and

(D) The functional sequences accepted by the fitness function are collected by the computer.

55. The computer-implemented method of embodiment 53, further comprising randomly exchanging, by a computer, one or more subsequences from the mutated sequence with different sequences of the plurality of sequences.

56. The computer-implemented method of embodiment 53 or 54, wherein the fitness function comprises a threshold selected from the group consisting of a binary threshold, a numerical threshold, a multi-class threshold, a confidence threshold, a decision threshold, and any combination thereof.

57. The computer-implemented method of embodiment 55, wherein a functional sequence is accepted by the fitness function when a fitness score assigned to the functional sequence by the fitness function exceeds the threshold.

58. The computer-implemented method of any of embodiments 53-56, wherein the plurality of different sequences in (a) comprises a plurality of different naturally occurring sequences or different random sequences.

59. The computer-implemented method of any one of embodiments 40-57, wherein the functionally defined biological sequence comprises an amino acid sequence or nucleotide sequence of a protein or peptide, or an amino acid sequence or nucleotide sequence encoding a protein or peptide, optionally wherein the functionally defined biological sequence comprises a transcriptional activator, further optionally wherein the functionally defined biological sequence comprises an engineered gene effector.

60. The computer-implemented method of embodiment 58, wherein the protein or the peptide is an epigenetic regulator, a transcription factor, an enzyme, a nuclease, an agonist, an antagonist, a regulatory factor, or an inhibitor.

61. The computer-implemented method of any one of embodiments 40-59, wherein the functionally defined biological sequence comprises an amino acid sequence or a nucleotide sequence.

62. The computer-implemented method of any one of embodiments 40-60, wherein the functionally defined biological sequence comprises an amino acid sequence, and further wherein the fixed length is at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60, at least 65, at least 70, at least 75, at least 80, at least 85, at least 90, at least 95, at least 100, at least 105, at least 110, at least 115, at least 120, at least 125, at least 130, at least 140, at least 150, or at least 200 amino acids, or at most 500, at most 300, at most 200, at most 150, at most 100, at most 95, at most 90, at most 85, at most 75, or at most 70 amino acids, or optionally wherein the fixed length is within a range defined by any two of the foregoing values, e.g., 30-500 amino acids, 50-300 amino acids, at least 150-200 amino acids, 75-150 amino acids, or the like.

63. The computer-implemented method of any of embodiments 40-61, wherein the fitness function is based on one or more machine learning models, wherein the machine learning model is selected from the group consisting of a supervised machine learning model, an unsupervised machine learning model, a reinforcement learning model, a deep learning model, a transfer learning model, and any combination thereof.

64. The computer-implemented method of embodiment 62, wherein the one or more machine learning models are selected from the group consisting of classification models, regression models, decision tree models, convolutional Neural Networks (CNNs), recurrent Neural Networks (RNNs), limit gradient boosting (XGBoost), long and short term memory networks, generation of countermeasure networks (GAN), auto encoders, transformer networks, evolved monte carlo, and any combination thereof.

65. The computer-implemented method of embodiment 63, wherein the fitness function is based on an integrated model comprising a decision tree model and a convolutional neural network, optionally wherein the integrated model comprises CNNs and XGBoost.

66. A computer-implemented method as in any of the preceding embodiments, the method comprising evaluating, by a computer, a biological data set to generate an fitness function, the evaluating comprising:

Generating sequence embeddings from Large Protein Language Models (LPLM) based on biological datasets, and

Training a machine learning model with the generated sequence embedding as input, optionally wherein LPLM comprises an Evolutionary Scale Modeling (ESM) language model, optionally wherein LPLM comprises ESM-2.

67. The computer-implemented method of embodiment 65, wherein the machine learning model comprises an integrated model of two or more different models.

68. The computer-implemented method of embodiment 66, wherein the integrated model comprises CNNs and XGBoost.

69. The computer-implemented method of any of the preceding embodiments, wherein the plurality of different sequences comprises a plurality of different random sequences.

70. The computer-implemented method of any of the preceding embodiments, wherein the biological dataset comprises up to about 10 ⁵ biological sequences or biological sequences on the order of about 10 ⁵ biological sequences.

71. The computer-implemented method of any of the preceding embodiments, wherein up to 5% of the functionally defined biological sequences comprise functional sequences.

72. A computer-implemented system comprising a computing device including at least one processor and instructions executed by the at least one processor to provide an application, the application comprising:

(a) A software module configured to evaluate, by a computer, a sequence of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological data set, the biological data set comprising a functionally determined biological sequence having the fixed length;

(b) A software module configured to replace, by the computer, one or more random residues in the sequence to generate a mutated sequence;

(c) A software module configured to evaluate, by the computer, the mutant sequence based on the fitness function, and

(D) A software module configured to collect, by the computer, a sequence of functionalities accepted by the fitness function.

73. A non-transitory computer readable medium having stored thereon computer readable instructions that, when executed by a processor, cause the processor to perform a method comprising:

(a) Evaluating sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functionally determined biological sequences having the fixed length;

(b) Replacing one or more random residues in the sequence to generate a mutated sequence;

(c) Evaluating the mutant sequence based on the fitness function, and

(D) Functional sequences accepted by the fitness function are collected.

74. A computer-implemented system comprising a computing device comprising at least one processor and instructions executed by the at least one processor to provide an application comprising one or more software modules for performing the method of any of embodiments 40-67.

75. A non-transitory computer readable medium having stored thereon computer readable instructions which, when executed by a processor, cause the processor to perform the method of any of embodiments 37-67.

76. An engineered gene effector comprising one or more polypeptides produced by the method of any one of embodiments 37-67, or a sequence at least 85% identical thereto.

77. An engineered gene effector comprising a polypeptide of 85 amino acids in length comprising any one of SEQ ID NOs 1495, 1592, 1595, 1634, 1654, 1665, 1677, 1686, 1689, 1716, or a sequence at least 85% identical thereto.

78. The engineered gene effector of embodiments 72 or 73, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, optionally wherein the target gene is endogenous to the cell.

79. The engineered gene effector of any one of embodiments 72-74, wherein the polypeptide is coupled to a heterologous endonuclease, optionally wherein the heterologous endonuclease is a Cas protein.

80. The engineered gene effector of embodiment 75, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

81. The engineered gene effector of embodiments 75 or 76, wherein the polypeptide is fused to the heterologous endonuclease, optionally wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

82. A fusion protein, the fusion protein comprising:

the engineered gene effector of any one of embodiments 72-77, and

A heterologous endonuclease coupled to a polypeptide, optionally, wherein the heterologous endonuclease is a Cas protein.

83. A polynucleotide comprising a nucleotide sequence encoding the engineered gene effector or fusion protein of any one of embodiments 72-77.

84. A vector comprising the polynucleotide of embodiment 79.

85. A cell comprising the polynucleotide of embodiment 79 or the vector of embodiment 80.

86. A system, the system comprising:

The engineered gene effector of any one of embodiments 72-77;

Optionally, a heterologous endonuclease coupled to the engineered gene effector, wherein the heterologous endonuclease is a Cas protein, and

A guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell.

87. A combination of polynucleotides encoding the system of embodiment 82, wherein the combination of polynucleotides is configured to express in a cell a heterologous endonuclease coupled to an engineered gene effector and a guide nucleic acid.

88. A method of controlling a target gene in a cell, the method comprising contacting the cell with a system of embodiment 82 or a combination of polynucleotides of embodiment 83.

89. The method of embodiment 84, wherein the target gene is endogenous to the cell.

90. The method of embodiment 84 or 85, wherein the contacting is performed in vitro or ex vivo.

91. A computer-implemented system comprising a computing device comprising at least one processor and instructions executed by the at least one processor to provide an application, the application comprising:

(a) A software module configured to provide, by a computer, an fitness function trained on a biological data set, the biological data set comprising a functionally determined biological sequence having a fixed length;

(b) A software module configured to provide, by the computer, a plurality of different sequences comprising a fixed length, each sequence associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of a temperature gradient;

(c) Parallel in a plurality of different sequences:

(1) A software module configured to select, by the computer, one or more random positions for introducing substitutions in one or more of a plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and

For each of the one or more sequences, evaluating a first fitness change resulting from introducing a substitution at one or more randomly selected locations, and accepting or rejecting the substitution based on the evaluated first fitness change, and optionally further based on a temperature associated with the sequence, and/or

(2) A software module configured to select, by the computer, one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a successive temperature of a temperature gradient, optionally, up to 3 pairs of the plurality of different sequences, optionally, 1 pair of the plurality of different sequences, and

For each selected pair:

Selecting one or more domains for exchange between sequences of selected pairs, and

Evaluating the difference in fitness of the sequences of the selected pair due to the exchange of one or more domains, and

Accepting or rejecting one or more domain exchanges between the selected pairs based on the fitness differences and the temperatures associated with each sequence of the selected pairs, and

(D) A software module configured to be executed iteratively by the computer (c), wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domains of a previous iteration are swapped into a plurality of different sequences, resulting in one or more functional sequences having fitness that reaches or is above a desired fitness threshold.

92. An engineered gene effector comprising a polypeptide comprising any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

93. An engineered gene effector comprising a polypeptide comprising any one of SEQ ID NOs 1085, 122, 1084, 653, 1099 and 1107, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally, wherein any mutation thereof is a conservative substitution.

TABLE 6 list of examples of target genes (e.g., encoding proteins of interest)

List of proteins/target genes of interest
	A1BG、CCND3、FAM163A、KCNK10、NRG4、REM1、TECTB、A1CF、CCNDBP1、FAM163B、KCNK12、NRGN、REM2、TEDDM1、A2M、CCNE1、FAM166A、KCNK13、NRIP1、REN、TEF、A2ML1、CCNE2、FAM166B、KCNK15、NRIP2、RENBP、TEFM、A3GALT2、CCNF、FAM167A、KCNK16、NRIP3、REP15、TEK、A4GALT、CCNG1、FAM167B、KCNK17、NRK、REPIN1、TEKT1、A4GNT、CCNG2、FAM168A、KCNK18、NRL、REPS1、TEKT2、AAAS、CCNH、FAM168B、KCNK2、NRM、REPS2、TEKT3、AACS、CCNI、FAM169A、KCNK3、NRN1、RER1、TEKT4、AADAC、CCNI2、FAM169B、KCNK4、NRN1L、RERE、TEKT5、AADACL2、CCNJ、FAM170A、KCNK5、NRP1、RERG、TELO2、AADACL3、CCNJL、FAM170B、KCNK6、NRP2、RERGL、TEN1、AADACL4、CCNK、FAM171A1、KCNK7、NRROS、RESP18、TENC1、AADAT、CCNL1、FAM171A2、KCNK9、NRSN1、REST、TENM1、AAED1、CCNL2、FAM171B、KCNMA1、NRSN2、RET、TENM2、AAGAB、CCNO、FAM172A、KCNMB1、NRTN、RETN、TENM3、AAK1、CCNT1、FAM173A、KCNMB2、NRXN1、RETNLB、TENM4、AAMDC、CCNT2、FAM173B、KCNMB3、NRXN2、RETSAT、TEP1、AAMP、CCNY、FAM174A、KCNMB4、NRXN3、REV1、TEPP、AANAT、CCNYL1、FAM174B、KCNN1、NSA2、REV3L、TERF1、AAR2、CCP110、FAM175A、KCNN2、NSD1、REXO1、TERF2、AARD、CCPG1、FAM175B、KCNN3、NSDHL、REXO2、TERF2IP、AARS、CCR1、FAM177A1、KCNN4、NSF、REXO4、TERT、AARS2、CCR10、FAM177B、KCNQ1、NSFL1C、RFC1、TES、AARSD1、CCR2、FAM178A、KCNQ2、NSG1、RFC2、TESC、AASDH、CCR3、FAM178B、KCNQ3、NSL1、RFC3、TESK1、AASDHPPT、CCR4、FAM179A、KCNQ4、NSMAF、RFC4、TESK2、AASS、CCR5、FAM179B、KCNQ5、NSMCE1、RFC5、TESPA1、AATF、CCR6、FAM180A、KCNRG、NSMCE2、RFESD、TET1、AATK、CCR7、FAM180B、KCNS1、NSMCE4A、RFFL、TET2、ABAT、CCR8、FAM181A、KCNS2、NSMF、RFK、TET3、ABCA1、CCR9、FAM181B、KCNS3、NSRP1、RFNG、TEX10、ABCA10、CCRL2、FAM183A、KCNT1、NSUN2、RFPL1、TEX101、ABCA12、CCRN4L、FAM184A、KCNT2、NSUN3、RFPL2、TEX11、ABCA13、CCS、FAM184B、KCNU1、NSUN4、RFPL3、TEX12、ABCA2、CCSAP、FAM185A、KCNV1、NSUN5、RFPL4A、TEX13A、ABCA3、CCSER1、FAM186A、KCNV2、NSUN6、RFPL4AL1、TEX13B、ABCA4、CCSER2、FAM186B、KCP、NSUN7、RFPL4B、TEX14、ABCA5、CCT2、FAM187B、KCTD1、NT5C、RFT1、TEX15、ABCA6、CCT3、FAM188A、KCTD10、NT5C1A、RFTN1、TEX19、ABCA7、CCT4、FAM188B、KCTD11、NT5C1B、RFTN2、TEX2、ABCA8、CCT5、FAM189A1、KCTD12、NT5C1B-RDH14、RFWD2、TEX22、ABCA9、CCT6A、FAM189A2、KCTD13、NT5C2、RFWD3、TEX26、ABCB1、CCT6B、FAM189B、KCTD14、NT5C3A、RFX1、TEX261、ABCB10、CCT7、FAM192A、KCTD15、NT5C3B、RFX2、TEX264、ABCB11、CCT8、FAM193A、KCTD16、NT5DC1、RFX3、TEX28、ABCB4、CCT8L2、FAM193B、KCTD17、NT5DC2、RFX4、TEX29、ABCB5、CCZ1、FAM194A、KCTD18、NT5DC3、RFX5、TEX30、ABCB6、CCZ1B、FAM194B、KCTD19、NT5E、RFX6、TEX33、ABCB7、CD101、FAM195A、KCTD2、NT5M、RFX7、TEX35、ABCB8、CD109、FAM195B、KCTD20、NTAN1、RFX8、TEX36、ABCB9、CD14、FAM196A、KCTD21、NTF3、RFXANK、TEX37、ABCC1、CD151、FAM196B、KCTD3、NTF4、RFXAP、TEX38、ABCC10、CD160、FAM198A、KCTD4、NTHL1、RGAG1、TEX40、ABCC11、CD163、FAM198B、KCTD5、NTM、RGAG4、TEX9、ABCC12、CD163L1、FAM199X、KCTD6、NTMT1、RGCC、TF、ABCC2、CD164、FAM19A1、KCTD7、NTN1、RGL1、TFAM、ABCC3、CD164L2、FAM19A2、KCTD8、NTN3、RGL2、TFAP2A、ABCC4、CD177、
FAM19A3、KCTD9、NTN4、RGL3、TFAP2B、ABCC5、CD180、FAM19A4、KDELC1、NTN5、RGL4、TFAP2C、ABCC6、CD19、FAM19A5、KDELC2、NTNG1、RGMA、TFAP2D、ABCC8、CD1A、FAM200A、KDELR1、NTNG2、RGMB、TFAP2E、ABCC9、CD1B、FAM203A、KDELR2、NTPCR、RGN、TFAP4、ABCD1、CD1C、FAM203B、KDELR3、NTRK1、RGP1、TFB1M、ABCD2、CD1D、FAM204A、KDM1A、NTRK2、RGPD1、TFB2M、ABCD3、CD1E、FAM205A、KDM1B、NTRK3、RGPD2、TFCP2、ABCD4、CD2、FAM206A、KDM2A、NTS、RGPD3、TFCP2L1、ABCE1、CD200、FAM207A、KDM2B、NTSR1、RGPD4、TFDP1、ABCF1、CD200R1、FAM208A、KDM3A、NTSR2、RGPD5、TFDP2、ABCF2、CD200R1L、FAM208B、KDM3B、NUAK1、RGPD6、TFDP3、ABCF3、CD207、FAM209A、KDM4A、NUAK2、RGPD8、TFE3、ABCG1、CD209、FAM209B、KDM4B、NUB1、RGR、TFEB、ABCG2、CD22、FAM20A、KDM4C、NUBP1、RGS1、TFEC、ABCG4、CD226、FAM20B、KDM4D、NUBP2、RGS10、TFF1、ABCG5、CD24、FAM20C、KDM4E、NUBPL、RGS11、TFF2、ABCG8、CD244、FAM210A、KDM5A、NUCB1、RGS12、TFF3、ABHD1、CD247、FAM210B、KDM5B、NUCB2、RGS13、TFG、ABHD10、CD248、FAM211A、KDM5C、NUCKS1、RGS14、TFIP11、ABHD11、CD27、FAM211B、KDM5D、NUDC、RGS16、TFPI、ABHD12、CD274、FAM212A、KDM6A、NUDCD1、RGS17、TFPI2、ABHD12B、CD276、FAM212B、KDM6B、NUDCD2、RGS18、TFPT、ABHD13、CD28、FAM213A、KDM8、NUDCD3、RGS19、TFR2、ABHD14A、CD2AP、FAM213B、KDR、NUDT1、RGS2、TFRC、ABHD14B、CD2BP2、FAM214A、KDSR、NUDT10、RGS20、TG、ABHD15、CD300A、FAM214B、KEAP1、NUDT11、RGS21、TGDS、ABHD16A、CD300C、FAM216A、KEL、NUDT12、RGS22、TGFA、ABHD16B、CD300E、FAM216B、KERA、NUDT13、RGS3、TGFB1、ABHD17A、CD300LB、FAM217A、KHDC1、NUDT14、RGS4、TGFB1I1、ABHD17B、CD300LD、FAM217B、KHDC1L、NUDT15、RGS5、TGFB2、ABHD17C、CD300LF、FAM218A、KHDC3L、NUDT16、RGS6、TGFB3、ABHD2、CD300LG、FAM219A、KHDRBS1、NUDT16L1、RGS7、TGFBI、ABHD3、CD302、FAM219B、KHDRBS2、NUDT17、RGS7BP、TGFBR1、ABHD4、CD320、FAM21A、KHDRBS3、NUDT18、RGS8、TGFBR2、ABHD5、CD33、FAM21B、KHK、NUDT19、RGS9、TGFBR3、ABHD6、CD34、FAM21C、KHNYN、NUDT2、RGS9BP、TGFBR3L、ABHD8、CD36、FAM220A、KHSRP、NUDT21、RGSL1、TGFBRAP1、ABI1、CD37、FAM221A、KIAA0020、NUDT22、RHAG、TGIF1、ABI2、CD38、FAM221B、KIAA0040、NUDT3、RHBDD1、TGIF2、ABI3、CD3D、FAM222A、KIAA0100、NUDT4、RHBDD2、TGIF2-C20orf24、ABI3BP、CD3E、FAM222B、KIAA0101、NUDT5、RHBDD3、TGIF2LX、ABL1、CD3EAP、FAM227A、KIAA0141、NUDT6、RHBDF1、TGIF2LY、ABL2、CD3G、FAM227B、KIAA0195、NUDT7、RHBDF2、TGM1、ABLIM1、CD4、FAM228A、KIAA0196、NUDT8、RHBDL1、TGM2、ABLIM2、CD40、FAM228B、KIAA0226、NUDT9、RHBDL2、TGM3、ABLIM3、CD40LG、FAM229A、KIAA0226L、NUF2、RHBDL3、TGM4、ABO、CD44、FAM229B、KIAA0232、NUFIP1、RHBG、TGM5、ABR、CD46、FAM230A、KIAA0247、NUFIP2、RHCE、TGM6、ABRA、CD47、FAM24A、KIAA0319、NUGGC、RHCG、TGM7、ABRACL、CD48、FAM24B、KIAA0319L、NUMA1、RHD、TGOLN2、ABT1、CD5、FAM25A、KIAA0355、NUMB、RHEB、TGS1、ABTB1、CD52、FAM25C、KIAA0368、NUMBL、RHEBL1、TH、ABTB2、CD53、FAM25G、KIAA0391、NUP107、RHNO1、THADA、ACAA1、CD55、FAM26D、KIAA0408、NUP133、RHO、THAP1、ACAA2、CD58、FAM26E、KIAA0430、NUP153、RHOA、THAP10、ACACA、CD59、FAM26F、KIAA0513、
	NUP155、RHOB、THAP11、ACACB、CD5L、FAM32A、KIAA0556、NUP160、RHOBTB1、THAP2、ACAD10、CD6、FAM35A、KIAA0586、NUP188、RHOBTB2、THAP3、ACAD11、CD63、FAM3A、KIAA0753、NUP205、RHOBTB3、THAP4、ACAD8、CD68、FAM3B、KIAA0754、NUP210、RHOC、THAP5、ACAD9、CD69、FAM3C、KIAA0825、NUP210L、RHOD、THAP6、ACADL、CD7、FAM3D、KIAA0895、NUP214、RHOF、THAP7、ACADM、CD70、FAM43A、KIAA0895L、NUP35、RHOG、THAP8、ACADS、CD72、FAM43B、KIAA0907、NUP37、RHOH、THAP9、ACADSB、CD74、FAM45A、KIAA0922、NUP43、RHOJ、THBD、ACADVL、CD79A、FAM46A、KIAA0930、NUP50、RHOQ、THBS1、ACAN、CD79B、FAM46B、KIAA0947、NUP54、RHOT1、THBS2、ACAP1、CD80、FAM46C、KIAA1009、NUP62、RHOT2、THBS3、ACAP2、CD81、FAM46D、KIAA1024、NUP62CL、RHOU、THBS4、ACAP3、CD82、FAM47A、KIAA1024L、NUP85、RHOV、THEG、ACAT1、CD83、FAM47B、KIAA1033、NUP88、RHOXF1、THEG5、ACAT2、CD84、FAM47C、KIAA1045、NUP93、RHOXF2、THEGL、ACBD3、CD86、FAM47E、KIAA1107、NUP98、RHOXF2B、THEM4、ACBD4、CD8A、FAM47E-STBD1、KIAA1109、NUPL1、RHPN1、THEM5、ACBD5、CD8B、FAM49A、KIAA1143、NUPL2、RHPN2、THEM6、ACBD6、CD9、FAM49B、KIAA1147、NUPR1、RIBC1、THEMIS、ACBD7、CD93、FAM50A、KIAA1161、NUPR1L、RIBC2、THEMIS2、ACCS、CD96、FAM50B、KIAA1191、NUS1、RIC3、THG1L、ACCSL、CD97、FAM53A、KIAA1199、NUSAP1、RIC8A、THNSL1、ACD、CD99、FAM53B、KIAA1210、NUTF2、RIC8B、THNSL2、ACE、CD99L2、FAM53C、KIAA1211、NUTM1、RICTOR、THOC1、ACE2、CDA、FAM57A、KIAA1211L、NUTM2A、RIF1、THOC2、ACER1、CDADC1、FAM57B、KIAA1217、NUTM2B、RIIAD1、THOC3、ACER2、CDAN1、FAM58A、KIAA1239、NUTM2F、RILP、THOC5、ACER3、CDC123、FAM60A、KIAA1244、NUTM2G、RILPL1、THOC6、ACHE、CDC14A、FAM63A、KIAA1257、NVL、RILPL2、THOC7、ACIN1、CDC14B、FAM63B、KIAA1279、NWD1、RIMBP2、THOP1、ACKR1、CDC16、FAM64A、KIAA1324、NXF1、RIMBP3、THPO、ACKR2、CDC20、FAM65A、KIAA1324L、NXF2、RIMBP3B、THRA、ACKR3、CDC20B、FAM65B、KIAA1328、NXF2B、RIMBP3C、THRAP3、ACKR4、CDC23、FAM65C、KIAA1377、NXF3、RIMKLA、THRB、ACLY、CDC25A、FAM69A、KIAA1407、NXF5、RIMKLB、THRSP、ACMSD、CDC25B、FAM69B、KIAA1429、NXN、RIMS1、THSD1、ACN9、CDC25C、FAM69C、KIAA1430、NXNL1、RIMS2、THSD4、ACO1、CDC26、FAM71A、KIAA1432、NXNL2、RIMS3、THSD7A、ACO2、CDC27、FAM71B、KIAA1456、NXPE1、RIMS4、THSD7B、ACOT1、CDC34、FAM71C、KIAA1462、NXPE2、RIN1、THTPA、ACOT11、CDC37、FAM71D、KIAA1467、NXPE3、RIN2、THUMPD1、ACOT12、CDC37L1、FAM71E1、KIAA1468、NXPE4、RIN3、THUMPD2、ACOT13、CDC40、FAM71E2、KIAA1522、NXPH1、RING1、THUMPD3、ACOT2、CDC42、FAM71F1、KIAA1524、NXPH2、RINL、THY1、ACOT4、CDC42BPA、FAM71F2、KIAA1549、NXPH3、RINT1、THYN1、ACOT6、CDC42BPB、FAM72A、KIAA1549L、NXPH4、RIOK1、TIA1、ACOT7、CDC42BPG、FAM72B、KIAA1551、NXT1、RIOK2、TIAF1、ACOT8、CDC42EP1、FAM72D、KIAA1586、NXT2、RIOK3、TIAL1、ACOT9、CDC42EP2、FAM73A、KIAA1598、NYAP1、RIPK1、TIAM1、ACOX1、CDC42EP3、FAM73B、KIAA1614、NYAP2、RIPK2、TIAM2、ACOX2、CDC42EP4、FAM76A、KIAA1644、NYNRIN、RIPK3、TICAM1、ACOX3、CDC42EP5、FAM76B、KIAA1671、NYX、RIPK4、TICAM2、ACOXL、CDC42SE1、FAM78A、KIAA1683、OAF、RIPPLY1、TICRR、
ACP1、CDC42SE2、FAM78B、KIAA1715、OARD1、RIPPLY2、TIE1、ACP2、CDC45、FAM81A、KIAA1731、OAS1、RIPPLY3、TIFA、ACP5、CDC5L、FAM81B、KIAA1737、OAS2、RIT1、TIFAB、ACP6、CDC6、FAM83A、KIAA1751、OAS3、RIT2、TIGD2、ACPL2、CDC7、FAM83B、KIAA1755、OASL、RLBP1、TIGD3、ACPP、CDC73、FAM83C、KIAA1804、OAT、RLF、TIGD4、ACPT、CDCA2、FAM83D、KIAA1841、OAZ1、RLIM、TIGD5、ACR、CDCA3、FAM83E、KIAA1919、OAZ2、RLN1、TIGD6、ACRBP、CDCA4、FAM83F、KIAA1958、OAZ3、RLN2、TIGD7、ACRC、CDCA5、FAM83G、KIAA1984、OBFC1、RLN3、TIGIT、ACRV1、CDCA7、FAM83H、KIAA2013、OBP2A、RLTPR、TIMD4、ACSBG1、CDCA7L、FAM84A、KIAA2018、OBP2B、RMDN1、TIMELESS、ACSBG2、CDCA8、FAM84B、KIAA2022、OBSCN、RMDN2、TIMM10、ACSF2、CDCP1、FAM86A、KIAA2026、OBSL1、RMDN3、TIMM10B、ACSF3、CDCP2、FAM86B1、KIDINS220、OC90、RMI1、TIMM13、ACSL1、CDH1、FAM86B2、KIF11、OCA2、RMI2、TIMM17A、ACSL3、CDH10、FAM86C1、KIF12、OCEL1、RMND1、TIMM17B、ACSL4、CDH11、FAM86KP、KIF13A、OCIAD1、RMND5A、TIMM21、ACSL5、CDH12、FAM89A、KIF13B、OCIAD2、RMND5B、TIMM22、ACSL6、CDH13、FAM89B、KIF14、OCLM、RNASE1、TIMM23、ACSM1、CDH15、FAM8A1、KIF15、OCLN、RNASE10、TIMM23B、ACSM2A、CDH16、FAM90A1、KIF16B、OCM、RNASE11、TIMM44、ACSM2B、CDH17、FAM91A1、KIF17、OCM2、RNASE12、TIMM50、ACSM3、CDH18、FAM92A1、KIF18A、OCRL、RNASE13、TIMM8A、ACSM4、CDH19、FAM92B、KIF18B、OCSTAMP、RNASE2、TIMM8B、ACSM5、CDH2、FAM96A、KIF19、ODAM、RNASE3、TIMM9、ACSS1、CDH20、FAM96B、KIF1A、ODC1、RNASE4、TIMMDC1、ACSS2、CDH22、FAM98A、KIF1B、ODF1、RNASE6、TIMP1、ACSS3、CDH23、FAM98B、KIF1C、ODF2、RNASE7、TIMP2、ACTA1、CDH24、FAM98C、KIF20A、ODF2L、RNASE8、TIMP3、ACTA2、CDH26、FAM9A、KIF20B、ODF3、RNASE9、TIMP4、ACTB、CDH3、FAM9B、KIF21A、ODF3B、RNASEH1、TINAG、ACTBL2、CDH4、FAM9C、KIF21B、ODF3L1、RNASEH2A、TINAGL1、ACTC1、CDH5、FAN1、KIF22、ODF3L2、RNASEH2B、TINF2、ACTG1、CDH6、FANCA、KIF23、ODF4、RNASEH2C、TIPARP、ACTG2、CDH7、FANCB、KIF24、OFCC1、RNASEK、TIPIN、ACTL10、CDH8、FANCC、KIF25、OFD1、RNASEL、TIPRL、ACTL6A、CDH9、FANCD2、KIF26A、OGDH、RNASET2、TIRAP、ACTL6B、CDHR1、FANCD2OS、KIF26B、OGDHL、RND1、TJAP1、ACTL7A、CDHR2、FANCE、KIF27、OGFOD1、RND2、TJP1、ACTL7B、CDHR3、FANCF、KIF28P、OGFOD2、RND3、TJP2、ACTL8、CDHR4、FANCG、KIF2A、OGFOD3、RNF10、TJP3、ACTL9、CDHR5、FANCI、KIF2B、OGFR、RNF103、TK1、ACTN1、CDIP1、FANCL、KIF2C、OGFRL1、RNF103-CHMP3、TK2、ACTN2、CDIPT、FANCM、KIF3A、OGG1、RNF11、TKT、ACTN3、CDK1、FANK1、KIF3B、OGN、RNF111、TKTL1、ACTN4、CDK10、FAP、KIF3C、OGT、RNF112、TKTL2、ACTR10、CDK11A、FAR1、KIF4A、OIP5、RNF113A、TLCD1、ACTR1A、CDK11B、FAR2、KIF4B、OIT3、RNF113B、TLCD2、ACTR1B、CDK12、FARP1、KIF5A、OLA1、RNF114、TLDC1、ACTR2、CDK13、FARP2、KIF5B、OLAH、RNF115、TLDC2、ACTR3、CDK14、FARS2、KIF5C、OLFM1、RNF121、TLE1、ACTR3B、CDK15、FARSA、KIF6、OLFM2、RNF122、TLE2、ACTR3C、CDK16、FARSB、KIF7、OLFM3、RNF123、TLE3、ACTR5、CDK17、FAS、KIF9、OLFM4、RNF125、TLE4、ACTR6、CDK18、FASLG、KIFAP3、OLFML1、RNF126、TLE6、ACTR8、CDK19、FASN、KIFC1、OLFML2A、RNF128、TLK1、ACTRT1、CDK2、FASTK、KIFC2、OLFML2B、
	RNF13、TLK2、ACTRT2、CDK20、FASTKD1、KIFC3、OLFML3、RNF130、TLL1、ACTRT3、CDK2AP1、FASTKD2、KIN、OLIG1、RNF133、TLL2、ACVR1、CDK2AP2、FASTKD3、KIR2DL1、OLIG2、RNF135、TLN1、ACVR1B、CDK3、FASTKD5、KIR2DL3、OLIG3、RNF138、TLN2、ACVR1C、CDK4、FAT1、KIR2DL4、OLR1、RNF139、TLR1、ACVR2A、CDK5、FAT2、KIR2DS4、OMA1、RNF14、TLR10、ACVR2B、CDK5R1、FAT3、KIR3DL1、OMD、RNF141、TLR2、ACVRL1、CDK5R2、FAT4、KIR3DL2、OMG、RNF144A、TLR3、ACY1、CDK5RAP1、FATE1、KIR3DL3、OMP、RNF144B、TLR4、ACY3、CDK5RAP2、FAU、KIRREL、ONECUT1、RNF145、TLR5、ACYP1、CDK5RAP3、FAXC、KIRREL2、ONECUT2、RNF146、TLR6、ACYP2、CDK6、FAXDC2、KIRREL3、ONECUT3、RNF148、TLR7、ADA、CDK7、FBF1、KISS1、OOEP、RNF149、TLR8、ADAD1、CDK8、FBL、KISS1R、OOSP2、RNF150、TLR9、ADAD2、CDK9、FBLIM1、KIT、OPA1、RNF151、TLX1、ADAL、CDKAL1、FBLN1、KITLG、OPA3、RNF152、TLX1NB、ADAM10、CDKL1、FBLN2、KL、OPALIN、RNF157、TLX2、ADAM11、CDKL2、FBLN5、KLB、OPCML、RNF165、TLX3、ADAM12、CDKL3、FBLN7、KLC1、OPHN1、RNF166、TM2D1、ADAM15、CDKL4、FBN1、KLC2、OPLAH、RNF167、TM2D2、ADAM17、CDKL5、FBN2、KLC3、OPN1LW、RNF168、TM2D3、ADAM18、CDKN1A、FBN3、KLC4、OPN1MW、RNF169、TM4SF1、ADAM19、CDKN1B、FBP1、KLF1、OPN1MW2、RNF17、TM4SF18、ADAM2、CDKN1C、FBP2、KLF10、OPN1SW、RNF170、TM4SF19、ADAM20、CDKN2A、FBRS、KLF11、OPN3、RNF175、TM4SF20、ADAM21、CDKN2AIP、FBRSL1、KLF12、OPN4、RNF180、TM4SF4、ADAM22、CDKN2AIPNL、FBXL12、KLF13、OPN5、RNF181、TM4SF5、ADAM23、CDKN2B、FBXL13、KLF14、OPRD1、RNF182、TM6SF1、ADAM28、CDKN2C、FBXL14、KLF15、OPRK1、RNF183、TM6SF2、ADAM29、CDKN2D、FBXL15、KLF16、OPRL1、RNF185、TM7SF2、ADAM30、CDKN3、FBXL16、KLF17、OPRM1、RNF186、TM7SF3、ADAM32、CDNF、FBXL17、KLF2、OPTC、RNF187、TM9SF1、ADAM33、CDO1、FBXL18、KLF3、OPTN、RNF19A、TM9SF2、ADAM7、CDON、FBXL19、KLF4、OR10A2、RNF19B、TM9SF3、ADAM8、CDPF1、FBXL2、KLF5、OR10A3、RNF2、TM9SF4、ADAM9、CDR1、FBXL20、KLF6、OR10A4、RNF20、TMA16、ADAMDEC1、CDR2、FBXL21、KLF7、OR10A5、RNF207、TMA7、ADAMTS1、CDR2L、FBXL22、KLF8、OR10A6、RNF208、TMBIM1、ADAMTS10、CDRT1、FBXL3、KLF9、OR10A7、RNF212、TMBIM4、ADAMTS12、CDRT15、FBXL4、KLHDC1、OR10AG1、RNF213、TMBIM6、ADAMTS13、CDRT15L2、FBXL5、KLHDC10、OR10C1、RNF214、TMC1、ADAMTS14、CDRT4、FBXL6、KLHDC2、OR10G2、RNF215、TMC2、ADAMTS15、CDS1、FBXL7、KLHDC3、OR10G3、RNF216、TMC3、ADAMTS16、CDS2、FBXL8、KLHDC4、OR10G4、RNF217、TMC4、ADAMTS17、CDSN、FBXO10、KLHDC7A、OR10G7、RNF219、TMC5、ADAMTS18、CDT1、FBXO11、KLHDC7B、OR10G8、RNF220、TMC6、ADAMTS19、CDV3、FBXO15、KLHDC8A、OR10G9、RNF222、TMC7、ADAMTS2、CDX1、FBXO16、KLHDC8B、OR10H1、RNF223、TMC8、ADAMTS20、CDX2、FBXO17、KLHDC9、OR10H2、RNF224、TMCC1、ADAMTS3、CDX4、FBXO18、KLHL1、OR10H3、RNF24、TMCC2、ADAMTS4、CDY1、FBXO2、KLHL10、OR10H4、RNF25、TMCC3、ADAMTS5、CDY1B、FBXO21、KLHL11、OR10H5、RNF26、TMCO1、ADAMTS6、CDY2A、FBXO22、KLHL12、OR10J1、RNF31、TMCO2、ADAMTS7、CDY2B、FBXO24、KLHL13、OR10J3、RNF32、TMCO3、ADAMTS8、CDYL、FBXO25、KLHL14、OR10J5、RNF34、TMCO4、ADAMTS9、CDYL2、FBXO27、KLHL15、OR10K1、RNF38、TMCO5A、ADAMTSL1、CEACAM1、FBXO28、
KLHL17、OR10K2、RNF39、TMCO6、ADAMTSL2、CEACAM16、FBXO3、KLHL18、OR10P1、RNF4、TMED1、ADAMTSL3、CEACAM18、FBXO30、KLHL2、OR10Q1、RNF40、TMED10、ADAMTSL4、CEACAM19、FBXO31、KLHL20、OR10R2、RNF41、TMED2、ADAMTSL5、CEACAM20、FBXO32、KLHL21、OR10S1、RNF43、TMED3、ADAP1、CEACAM21、FBXO33、KLHL22、OR10T2、RNF44、TMED4、ADAP2、CEACAM3、FBXO34、KLHL23、OR10V1、RNF5、TMED5、ADAR、CEACAM4、FBXO36、KLHL24、OR10W1、RNF6、TMED6、ADARB1、CEACAM5、FBXO38、KLHL25、OR10X1、RNF7、TMED7、ADARB2、CEACAM6、FBXO39、KLHL26、OR10Z1、RNF8、TMED7-TICAM2、ADAT1、CEACAM7、FBXO4、KLHL28、OR11A1、RNFT1、TMED8、ADAT2、CEACAM8、FBXO40、KLHL29、OR11G2、RNFT2、TMED9、ADAT3、CEBPA、FBXO41、KLHL3、OR11H1、RNGTT、TMEFF1、ADC、CEBPB、FBXO42、KLHL30、OR11H12、RNH1、TMEFF2、ADCK1、CEBPD、FBXO43、KLHL31、OR11H2、RNLS、TMEM100、ADCK2、CEBPE、FBXO44、KLHL32、OR11H4、RNMT、TMEM101、ADCK3、CEBPG、FBXO45、KLHL33、OR11H6、RNMTL1、TMEM102、ADCK4、CEBPZ、FBXO46、KLHL34、OR11L1、RNPC3、TMEM104、ADCK5、CECR1、FBXO47、KLHL35、OR12D2、RNPEP、TMEM105、ADCY1、CECR2、FBXO48、KLHL36、OR12D3、RNPEPL1、TMEM106A、ADCY10、CECR5、FBXO5、KLHL38、OR13A1、RNPS1、TMEM106B、ADCY2、CECR6、FBXO6、KLHL4、OR13C2、ROBO1、TMEM106C、ADCY3、CEL、FBXO7、KLHL40、OR13C3、ROBO2、TMEM107、ADCY4、CELA1、FBXO8、KLHL41、OR13C4、ROBO3、TMEM108、ADCY5、CELA2A、FBXO9、KLHL42、OR13C5、ROBO4、TMEM109、ADCY6、CELA2B、FBXW10、KLHL5、OR13C8、ROCK1、TMEM11、ADCY7、CELA3A、FBXW11、KLHL6、OR13C9、ROCK2、TMEM110、ADCY8、CELA3B、FBXW12、KLHL7、OR13D1、ROGDI、TMEM110-MUSTN1、ADCY9、CELF1、FBXW2、KLHL8、OR13F1、ROM1、TMEM114、ADCYAP1、CELF2、FBXW4、KLHL9、OR13G1、ROMO1、TMEM115、ADCYAP1R1、CELF3、FBXW5、KLK1、OR13H1、ROPN1、TMEM116、ADD1、CELF4、FBXW7、KLK10、OR13J1、ROPN1B、TMEM117、ADD2、CELF5、FBXW8、KLK11、OR14A16、ROPN1L、TMEM119、ADD3、CELF6、FBXW9、KLK12、OR14C36、ROR1、TMEM120A、ADGB、CELSR1、FCAMR、KLK13、OR14J1、ROR2、TMEM120B、ADH1A、CELSR2、FCAR、KLK14、OR1A1、RORA、TMEM121、ADH1B、CELSR3、FCER1A、KLK15、OR1A2、RORB、TMEM123、ADH1C、CEMP1、FCER1G、KLK2、OR1B1、RORC、TMEM125、ADH4、CEND1、FCER2、KLK3、OR1C1、ROS1、TMEM126A、ADH5、CENPA、FCF1、KLK4、OR1D2、RP1、TMEM126B、ADH6、CENPB、FCGBP、KLK5、OR1D5、RP1L1、TMEM127、ADH7、CENPBD1、FCGR1A、KLK6、OR1E1、RP2、TMEM128、ADHFE1、CENPC、FCGR1B、KLK7、OR1E2、RP9、TMEM129、ADI1、CENPE、FCGR2A、KLK8、OR1F1、RPA1、TMEM130、ADIG、CENPF、FCGR2B、KLK9、OR1G1、RPA2、TMEM131、ADIPOQ、CENPH、FCGR2C、KLKB1、OR1I1、RPA3、TMEM132A、ADIPOR1、CENPI、FCGR3A、KLLN、OR1J1、RPA4、TMEM132B、ADIPOR2、CENPJ、FCGR3B、KLRB1、OR1J4、RPAIN、TMEM132C、ADIRF、CENPK、FCGRT、KLRC1、OR1K1、RPAP1、TMEM132D、ADK、CENPL、FCHO1、KLRC2、OR1L1、RPAP2、TMEM132E、ADM、CENPM、FCHO2、KLRC3、OR1L3、RPAP3、TMEM133、ADM2、CENPN、FCHSD1、KLRC4、OR1L4、RPE、TMEM134、ADM5、CENPO、FCHSD2、KLRC4-KLRK1、OR1L6、RPE65、TMEM135、ADNP、CENPP、FCN1、KLRD1、OR1L8、RPF1、TMEM136、ADNP2、CENPQ、FCN2、KLRF1、OR1M1、RPF2、TMEM138、ADO、CENPT、FCN3、KLRF2、OR1N1、RPGR、
	TMEM139、ADORA1、CENPU、FCRL1、KLRG1、OR1N2、RPGRIP1、TMEM140、ADORA2A、CENPV、FCRL2、KLRG2、OR1Q1、RPGRIP1L、TMEM141、ADORA2B、CENPW、FCRL3、KLRK1、OR1S1、RPH3A、TMEM143、ADORA3、CEP104、FCRL4、KMO、OR1S2、RPH3AL、TMEM144、ADPGK、CEP112、FCRL5、KMT2A、OR2A12、RPIA、TMEM145、ADPRH、CEP120、FCRL6、KMT2B、OR2A14、RPL10、TMEM147、ADPRHL1、CEP128、FCRLA、KMT2C、OR2A2、RPL10A、TMEM14A、ADPRHL2、CEP135、FCRLB、KMT2D、OR2A25、RPL10L、TMEM14B、ADPRM、CEP152、FDCSP、KMT2E、OR2A4、RPL11、TMEM14C、ADRA1A、CEP164、FDFT1、KNCN、OR2A5、RPL12、TMEM14E、ADRA1B、CEP170、FDPS、KNDC1、OR2A7、RPL13、TMEM150A、ADRA1D、CEP170B、FDX1、KNG1、OR2AE1、RPL13A、TMEM150B、ADRA2A、CEP19、FDX1L、KNOP1、OR2AG1、RPL14、TMEM150C、ADRA2B、CEP192、FDXACB1、KNSTRN、OR2AG2、RPL15、TMEM151A、ADRA2C、CEP250、FDXR、KNTC1、OR2AK2、RPL17、TMEM151B、ADRB1、CEP290、FECH、KPNA1、OR2AP1、RPL17-C18orf32、TMEM154、ADRB2、CEP350、FEM1A、KPNA2、OR2AT4、RPL18、TMEM155、ADRB3、CEP41、FEM1B、KPNA3、OR2B11、RPL18A、TMEM156、ADRBK1、CEP44、FEM1C、KPNA4、OR2B2、RPL19、TMEM158、ADRBK2、CEP55、FEN1、KPNA5、OR2B3、RPL21、TMEM159、ADRM1、CEP57、FER、KPNA6、OR2B6、RPL22、TMEM160、ADSL、CEP57L1、FER1L5、KPNA7、OR2C1、RPL22L1、TMEM161A、ADSS、CEP63、FER1L6、KPNB1、OR2C3、RPL23、TMEM161B、ADSSL1、CEP68、FERD3L、KPRP、OR2D2、RPL23A、TMEM163、ADTRP、CEP70、FERMT1、KPTN、OR2D3、RPL24、TMEM164、AEBP1、CEP72、FERMT2、KRAS、OR2F1、RPL26、TMEM165、AEBP2、CEP76、FERMT3、KRBA1、OR2F2、RPL26L1、TMEM167A、AEN、CEP78、FES、KRBA2、OR2G2、RPL27、TMEM167B、AES、CEP85、FETUB、KRBOX1、OR2G3、RPL27A、TMEM168、AFAP1、CEP85L、FEV、KRBOX4、OR2G6、RPL28、TMEM169、AFAP1L1、CEP89、FEZ1、KRCC1、OR2H1、RPL29、TMEM17、AFAP1L2、CEP95、FEZ2、KREMEN1、OR2J2、RPL3、TMEM170A、AFF1、CEP97、FEZF1、KREMEN2、OR2J3、RPL30、TMEM170B、AFF2、CEPT1、FEZF2、KRI1、OR2K2、RPL31、TMEM171、AFF3、CER1、FFAR1、KRIT1、OR2L13、RPL32、TMEM173、AFF4、CERCAM、FFAR2、KRR1、OR2L2、RPL34、TMEM174、AFG3L2、CERK、FFAR3、KRT1、OR2L3、RPL35、TMEM175、AFM、CERKL、FFAR4、KRT10、OR2L5、RPL35A、TMEM176A、AFMID、CERS1、FGA、KRT12、OR2L8、RPL36、TMEM176B、AFP、CERS2、FGB、KRT13、OR2M2、RPL36A、TMEM177、AFTPH、CERS3、FGD1、KRT14、OR2M3、RPL36A-HNRNPH2、TMEM178A、AGA、CERS4、FGD2、KRT15、OR2M4、RPL36AL、TMEM178B、AGAP1、CERS5、FGD3、KRT16、OR2M5、RPL37、TMEM179、AGAP10、CERS6、FGD4、KRT17、OR2M7、RPL37A、TMEM179B、AGAP11、CES1、FGD5、KRT18、OR2S2、RPL38、TMEM18、AGAP2、CES2、FGD6、KRT19、OR2T1、RPL39、TMEM180、AGAP3、CES3、FGF1、KRT2、OR2T10、RPL39L、TMEM181、AGAP4、CES4A、FGF10、KRT20、OR2T11、RPL3L、TMEM182、AGAP5、CES5A、FGF11、KRT222、OR2T12、RPL4、TMEM183A、AGAP6、CETN1、FGF12、KRT23、OR2T2、RPL41、TMEM183B、AGAP7、CETN2、FGF13、KRT24、OR2T27、RPL5、TMEM184A、AGAP8、CETN3、FGF14、KRT25、OR2T29、RPL6、TMEM184B、AGAP9、CETP、FGF16、KRT26、OR2T3、RPL7、TMEM184C、AGBL1、CFB、FGF17、KRT27、OR2T33、RPL7A、TMEM185A、AGBL2、CFC1、FGF18、KRT28、OR2T34、RPL7L1、TMEM185B、AGBL3、CFC1B、FGF19、KRT3、OR2T35、RPL8、TMEM186、
AGBL4、CFD、FGF2、KRT31、OR2T4、RPL9、TMEM187、AGBL5、CFDP1、FGF20、KRT32、OR2T5、RPLP0、TMEM189、AGER、CFH、FGF21、KRT33A、OR2T6、RPLP1、TMEM189-UBE2V1、AGFG1、CFHR1、FGF22、KRT33B、OR2T8、RPLP2、TMEM19、AGFG2、CFHR2、FGF23、KRT34、OR2V1、RPN1、TMEM190、AGGF1、CFHR3、FGF3、KRT35、OR2V2、RPN2、TMEM191B、AGK、CFHR4、FGF4、KRT36、OR2W1、RPP14、TMEM191C、AGL、CFHR5、FGF5、KRT37、OR2W3、RPP21、TMEM192、AGMAT、CFI、FGF6、KRT38、OR2W5、RPP25、TMEM194A、AGMO、CFL1、FGF7、KRT39、OR2Y1、RPP25L、TMEM194B、AGO1、CFL2、FGF8、KRT4、OR2Z1、RPP30、TMEM196、AGO2、CFLAR、FGF9、KRT40、OR3A1、RPP38、TMEM198、AGO3、CFP、FGFBP1、KRT5、OR3A2、RPP40、TMEM199、AGO4、CFTR、FGFBP2、KRT6A、OR3A3、RPRD1A、TMEM2、AGPAT1、CGA、FGFBP3、KRT6B、OR4A15、RPRD1B、TMEM200A、AGPAT2、CGB、FGFR1、KRT6C、OR4A16、RPRD2、TMEM200B、AGPAT3、CGB1、FGFR1OP、KRT7、OR4A47、RPRM、TMEM201、AGPAT4、CGB2、FGFR1OP2、KRT71、OR4A5、RPRML、TMEM202、AGPAT5、CGB5、FGFR2、KRT72、OR4B1、RPS10、TMEM203、AGPAT6、CGB7、FGFR3、KRT73、OR4C11、RPS10-NUDT3、TMEM204、AGPAT9、CGB8、FGFR4、KRT74、OR4C12、RPS11、TMEM205、AGPS、CGGBP1、FGFRL1、KRT75、OR4C13、RPS12、TMEM206、AGR2、CGN、FGG、KRT76、OR4C15、RPS13、TMEM207、AGR3、CGNL1、FGGY、KRT77、OR4C16、RPS14、TMEM208、AGRN、CGREF1、FGL1、KRT78、OR4C3、RPS15、TMEM209、AGRP、CGRRF1、FGL2、KRT79、OR4C45、RPS15A、TMEM210、AGT、CH25H、FGR、KRT8、OR4C46、RPS16、TMEM211、AGTPBP1、CHAC1、FH、KRT80、OR4C6、RPS17、TMEM212、AGTR1、CHAC2、FHAD1、KRT81、OR4D1、RPS17L、TMEM213、AGTR2、CHAD、FHDC1、KRT82、OR4D10、RPS18、TMEM214、AGTRAP、CHADL、FHIT、KRT83、OR4D11、RPS19、TMEM215、AGXT、CHAF1A、FHL1、KRT84、OR4D2、RPS19BP1、TMEM216、AGXT2、CHAF1B、FHL2、KRT85、OR4D5、RPS2、TMEM217、AHCTF1、CHAMP1、FHL3、KRT86、OR4D6、RPS20、TMEM218、AHCY、CHAT、FHL5、KRT9、OR4D9、RPS21、TMEM219、AHCYL1、CHCHD1、FHOD1、KRTAP10-1、OR4E2、RPS23、TMEM220、AHCYL2、CHCHD10、FHOD3、KRTAP10-10、OR4F15、RPS24、TMEM221、AHDC1、CHCHD2、FIBCD1、KRTAP10-11、OR4F16、RPS25、TMEM222、AHI1、CHCHD3、FIBIN、KRTAP10-12、OR4F21、RPS26、TMEM223、AHNAK、CHCHD4、FIBP、KRTAP10-2、OR4F29、RPS27、TMEM225、AHNAK2、CHCHD5、FICD、KRTAP10-3、OR4F3、RPS27A、TMEM229A、AHR、CHCHD6、FIG4、KRTAP10-4、OR4F4、RPS27L、TMEM229B、AHRR、CHCHD7、FIGF、KRTAP10-5、OR4F5、RPS28、TMEM230、AHSA1、CHD1、FIGLA、KRTAP10-6、OR4F6、RPS29、TMEM231、AHSA2、CHD1L、FIGN、KRTAP10-7、OR4K1、RPS3、TMEM232、AHSG、CHD2、FIGNL1、KRTAP10-8、OR4K13、RPS3A、TMEM233、AHSP、CHD3、FIGNL2、KRTAP10-9、OR4K14、RPS4X、TMEM234、AICDA、CHD4、FILIP1、KRTAP1-1、OR4K15、RPS4Y1、TMEM235、AIDA、CHD5、FILIP1L、KRTAP11-1、OR4K17、RPS4Y2、TMEM236、AIF1、CHD6、FIP1L1、KRTAP12-1、OR4K2、RPS5、TMEM237、AIF1L、CHD7、FIS1、KRTAP12-2、OR4K5、RPS6、TMEM238、AIFM1、CHD8、FITM1、KRTAP12-3、OR4L1、RPS6KA1、TMEM239、AIFM2、CHD9、FITM2、KRTAP12-4、OR4M1、RPS6KA2、TMEM240、AIFM3、CHDC2、FIZ1、KRTAP1-3、OR4M2、RPS6KA3、TMEM241、AIG1、CHDH、FJX1、KRTAP13-1、OR4N2、RPS6KA4、TMEM242、AIM1、CHEK1、FKBP10、KRTAP13-2、OR4N4、RPS6KA5、TMEM243、AIM1L、
	CHEK2、FKBP11、KRTAP13-3、OR4N5、RPS6KA6、TMEM244、AIM2、CHERP、FKBP14、KRTAP13-4、OR4P4、RPS6KB1、TMEM245、AIMP1、CHFR、FKBP15、KRTAP1-4、OR4Q3、RPS6KB2、TMEM246、AIMP2、CHGA、FKBP1A、KRTAP1-5、OR4S1、RPS6KC1、TMEM247、AIP、CHGB、FKBP1B、KRTAP15-1、OR4S2、RPS6KL1、TMEM248、AIPL1、CHI3L1、FKBP2、KRTAP16-1、OR4X1、RPS7、TMEM249、AIRE、CHI3L2、FKBP3、KRTAP17-1、OR4X2、RPS8、TMEM25、AJAP1、CHIA、FKBP4、KRTAP19-1、OR51A2、RPS9、TMEM251、AJUBA、CHIC1、FKBP5、KRTAP19-2、OR51A4、RPSA、TMEM252、AK1、CHIC2、FKBP6、KRTAP19-3、OR51A7、RPTN、TMEM253、AK2、CHID1、FKBP7、KRTAP19-4、OR51B2、RPTOR、TMEM254、AK3、CHIT1、FKBP8、KRTAP19-5、OR51B4、RPUSD1、TMEM255A、AK4、CHKA、FKBP9、KRTAP19-6、OR51B5、RPUSD2、TMEM255B、AK5、CHKB、FKBPL、KRTAP19-7、OR51B6、RPUSD3、TMEM256、AK6、CHL1、FKRP、KRTAP19-8、OR51D1、RPUSD4、TMEM257、AK7、CHM、FKTN、KRTAP20-1、OR51E1、RQCD1、TMEM258、AK8、CHML、FLAD1、KRTAP20-2、OR51E2、RRAD、TMEM259、AK9、CHMP1A、FLCN、KRTAP20-3、OR51F1、RRAGA、TMEM26、AKAP1、CHMP1B、FLG、KRTAP2-1、OR51F2、RRAGB、TMEM260、AKAP10、CHMP2A、FLG2、KRTAP21-1、OR51G1、RRAGC、TMEM261、AKAP11、CHMP2B、FLI1、KRTAP21-2、OR51G2、RRAGD、TMEM27、AKAP12、CHMP3、FLII、KRTAP21-3、OR51I1、RRAS、TMEM30A、AKAP13、CHMP4A、FLJ22184、KRTAP2-2、OR51I2、RRAS2、TMEM30B、AKAP14、CHMP4B、FLJ25363、KRTAP22-1、OR51L1、RRBP1、TMEM31、AKAP17A、CHMP4C、FLJ44313、KRTAP22-2、OR51M1、RREB1、TMEM33、AKAP2、CHMP5、FLJ44635、KRTAP2-3、OR51Q1、RRH、TMEM35、AKAP3、CHMP6、FLJ45513、KRTAP23-1、OR51S1、RRM1、TMEM37、AKAP4、CHMP7、FLNA、KRTAP2-4、OR51T1、RRM2、TMEM38A、AKAP5、CHN1、FLNB、KRTAP24-1、OR51V1、RRM2B、TMEM38B、AKAP6、CHN2、FLNC、KRTAP25-1、OR52A1、RRN3、TMEM39A、AKAP7、CHODL、FLOT1、KRTAP26-1、OR52A5、RRNAD1、TMEM39B、AKAP8、CHORDC1、FLOT2、KRTAP27-1、OR52B2、RRP1、TMEM40、AKAP8L、CHP1、FLRT1、KRTAP29-1、OR52B4、RRP12、TMEM41A、AKAP9、CHP2、FLRT2、KRTAP3-1、OR52B6、RRP15、TMEM41B、AKIP1、CHPF、FLRT3、KRTAP3-2、OR52D1、RRP1B、TMEM42、AKIRIN1、CHPF2、FLT1、KRTAP3-3、OR52E2、RRP36、TMEM43、AKIRIN2、CHPT1、FLT3、KRTAP4-1、OR52E4、RRP7A、TMEM44、AKNA、CHRAC1、FLT3LG、KRTAP4-11、OR52E6、RRP8、TMEM45A、AKNAD1、CHRD、FLT4、KRTAP4-12、OR52E8、RRP9、TMEM45B、AKR1A1、CHRDL1、FLVCR1、KRTAP4-2、OR52H1、RRS1、TMEM47、AKR1B1、CHRDL2、FLVCR2、KRTAP4-3、OR52I1、RS1、TMEM5、AKR1B10、CHRFAM7A、FLYWCH1、KRTAP4-4、OR52I2、RSAD1、TMEM50A、AKR1B15、CHRM1、FLYWCH2、KRTAP4-5、OR52J3、RSAD2、TMEM50B、AKR1C1、CHRM2、FMN1、KRTAP4-6、OR52K1、RSBN1、TMEM51、AKR1C2、CHRM3、FMN2、KRTAP4-7、OR52K2、RSBN1L、TMEM52、AKR1C3、CHRM4、FMNL1、KRTAP4-8、OR52L1、RSC1A1、TMEM52B、AKR1C4、CHRM5、FMNL2、KRTAP4-9、OR52M1、RSF1、TMEM53、AKR1D1、CHRNA1、FMNL3、KRTAP5-1、OR52N1、RSG1、TMEM54、AKR1E2、CHRNA10、FMO1、KRTAP5-10、OR52N4、RSL1D1、TMEM55A、AKR7A2、CHRNA2、FMO2、KRTAP5-11、OR52N5、RSL24D1、TMEM55B、AKR7A3、CHRNA3、FMO3、KRTAP5-2、OR52R1、RSPH1、TMEM56、AKT1、CHRNA4、FMO4、KRTAP5-3、OR52W1、RSPH10B、TMEM56-RWDD3、AKT1S1、CHRNA5、FMO5、KRTAP5-4、
OR56A1、RSPH10B2、TMEM57、AKT2、CHRNA6、FMOD、KRTAP5-5、OR56A3、RSPH3、TMEM59、AKT3、CHRNA7、FMR1、KRTAP5- 6、OR56A4、RSPH4A、TMEM59L、AKTIP、CHRNA9、FMR1NB、KRTAP5-7、OR56A5、RSPH6A、TMEM60、ALAD、CHRNB1、FN1、KRTAP5-8、OR56B1、RSPH9、TMEM61、ALAS1、CHRNB2、FN3K、KRTAP5-9、OR56B4、RSPO1、TMEM62、ALAS2、CHRNB3、FN3KRP、KRTAP6-1、OR5A1、RSPO2、TMEM63A、ALB、CHRNB4、FNBP1、KRTAP6-2、OR5A2、RSPO3、TMEM63B、ALCAM、CHRND、FNBP1L、KRTAP6-3、OR5AC2、RSPO4、TMEM63C、ALDH16A1、CHRNE、FNBP4、KRTAP7-1、OR5AK2、RSPRY1、TMEM64、ALDH18A1、CHRNG、FNDC1、KRTAP8-1、OR5AN1、RSRC1、TMEM65、ALDH1A1、CHST1、FNDC3A、KRTAP9-1、OR5AP2、RSRC2、TMEM66、ALDH1A2、CHST10、FNDC3B、KRTAP9-2、OR5AR1、RSU1、TMEM67、ALDH1A3、CHST11、FNDC4、KRTAP9-3、OR5AS1、RTBDN、TMEM68、ALDH1B1、CHST12、FNDC5、KRTAP9-4、OR5AU1、RTCA、TMEM69、ALDH1L1、CHST13、FNDC7、KRTAP9-6、OR5B12、RTCB、TMEM70、ALDH1L2、CHST14、FNDC8、KRTAP9-7、OR5B17、RTDR1、TMEM71、ALDH2、CHST15、FNDC9、KRTAP9- 8、OR5B2、RTEL1、TMEM72、ALDH3A1、CHST2、FNIP1、KRTAP9-9、OR5B21、RTF1、TMEM74、ALDH3A2、CHST3、FNIP2、KRTCAP2、OR5B3、RTFDC1、TMEM74B、ALDH3B1、CHST4、FNTA、KRTCAP3、OR5C1、RTKN、TMEM79、ALDH3B2、CHST5、FNTB、KRTDAP、OR5D13、RTKN2、TMEM80、ALDH4A1、CHST6、FOCAD、KSR1、OR5D14、RTL1、TMEM81、ALDH5A1、CHST7、FOLH1、KSR2、OR5D16、RTN1、TMEM82、ALDH6A1、CHST8、FOLH1B、KTI12、OR5D18、RTN2、TMEM86A、ALDH7A1、CHST9、FOLR1、KTN1、OR5F1、RTN3、TMEM86B、ALDH8A1、CHSY1、FOLR2、KXD1、OR5H1、RTN4、TMEM87A、ALDH9A1、CHSY3、FOLR3、KY、OR5H14、RTN4IP1、TMEM87B、ALDOA、CHTF18、FOLR4、KYNU、OR5H15、RTN4R、TMEM88、ALDOB、CHTF8、FOPNL、L1CAM、OR5H2、RTN4RL1、TMEM88B、ALDOC、CHtop、FOS、L1TD1、OR5H6、RTN4RL2、TMEM89、ALG1、CHUK、FOSB、L2HGDH、OR5I1、RTP1、TMEM8A、ALG10、CHURC1、FOSL1、L3HYPDH、OR5J2、RTP2、TMEM8B、ALG10B、CHURC1-FNTB、FOSL2、L3MBTL1、OR5K1、RTP3、TMEM8C、ALG11、CIAO1、FOXA1、L3MBTL2、OR5K2、RTP4、TMEM9、ALG12、CIAPIN1、FOXA2、L3MBTL3、OR5K3、RTTN、TMEM91、ALG13、CIB1、FOXA3、L3MBTL4、OR5K4、RUFY1、TMEM92、ALG14、CIB2、FOXB1、LACC1、OR5L1、RUFY2、TMEM95、ALG1L、CIB3、FOXB2、LACE1、OR5L2、RUFY3、TMEM97、ALG1L2、CIB4、FOXC1、LACRT、OR5M1、RUFY4、TMEM98、ALG2、CIC、FOXC2、LACTB、OR5M10、RUNDC1、TMEM99、ALG3、CIDEA、FOXD1、LACTB2、OR5M11、RUNDC3A、TMEM9B、ALG5、CIDEB、FOXD2、LACTBL1、OR5M3、RUNDC3B、TMF1、ALG6、CIDEC、FOXD3、LAD1、OR5M8、RUNX1、TMIE、ALG8、CIITA、FOXD4、LAG3、OR5M9、RUNX1T1、TMIGD1、ALG9、CILP、FOXD4L1、LAGE3、OR5P2、RUNX2、TMIGD2、ALK、CILP2、FOXD4L2、LAIR1、OR5P3、RUNX3、TMLHE、ALKBH1、CINP、FOXD4L3、LAIR2、OR5R1、RUSC1、TMOD1、ALKBH2、CIR1、FOXD4L4、LALBA、OR5T1、RUSC1-AS1、TMOD2、ALKBH3、CIRBP、FOXD4L5、LAMA1、OR5T2、RUSC2、TMOD3、ALKBH4、CIRH1A、FOXD4L6、LAMA2、OR5T3、RUVBL1、TMOD4、ALKBH5、CISD1、FOXE1、LAMA3、OR5V1、RUVBL2、TMPO、ALKBH6、CISD2、FOXE3、LAMA4、OR5W2、RWDD1、TMPPE、ALKBH7、CISD3、FOXF1、LAMA5、OR6A2、RWDD2A、TMPRSS11A、ALKBH8、CISH、FOXF2、LAMB1、OR6B1、RWDD2B、TMPRSS11B、ALLC、CIT、FOXG1、LAMB2、OR6B3、RWDD3、TMPRSS11D、
	ALMS1、CITED1、FOXH1、LAMB3、OR6C1、RWDD4、TMPRSS11E、ALOX12、CITED2、FOXI1、LAMB4、OR6C2、RXFP1、TMPRSS11F、ALOX12B、CITED4、FOXI2、LAMC1、OR6C3、RXFP2、TMPRSS12、ALOX15、CIZ1、FOXI3、LAMC2、OR6C4、RXFP3、TMPRSS13、ALOX15B、CKAP2、FOXJ1、LAMC3、OR6C6、RXFP4、TMPRSS15、ALOX5、CKAP2L、FOXJ2、LAMP1、OR6C65、RXRA、TMPRSS2、ALOX5AP、CKAP4、FOXJ3、LAMP2、OR6C68、RXRB、TMPRSS3、ALOXE3、CKAP5、FOXK1、LAMP3、OR6C70、RXRG、TMPRSS4、ALPI、CKB、FOXK2、LAMP5、OR6C74、RYBP、TMPRSS5、ALPK1、CKLF、FOXL1、LAMTOR1、OR6C75、RYK、TMPRSS6、ALPK2、CKLF-CMTM1、FOXL2、LAMTOR2、OR6C76、RYR1、TMPRSS7、ALPK3、CKM、FOXM1、LAMTOR3、OR6F1、RYR2、TMPRSS9、ALPL、CKMT1A、FOXN1、LAMTOR4、OR6K2、RYR3、TMSB10、ALPP、CKMT1B、FOXN2、LAMTOR5、OR6K3、S100A1、TMSB15A、ALPPL2、CKMT2、FOXN3、LANCL1、OR6K6、S100A10、TMSB15B、ALS2、CKS1B、FOXN4、LANCL2、OR6M1、S100A11、TMSB4X、ALS2CL、CKS2、FOXO1、LANCL3、OR6N1、S100A12、TMSB4Y、ALS2CR11、CLASP1、FOXO3、LAP3、OR6N2、S100A13、TMTC1、ALS2CR12、CLASP2、FOXO4、LAPTM4A、OR6P1、S100A14、TMTC2、ALX1、CLASRP、FOXO6、LAPTM4B、OR6Q1、S100A16、TMTC3、ALX3、CLC、FOXP1、LAPTM5、OR6S1、S100A2、TMTC4、ALX4、CLCA1、FOXP2、LARGE、OR6T1、S100A3、TMUB1、ALYREF、CLCA2、FOXP3、LARP1、OR6V1、S100A4、TMUB2、AMACR、CLCA4、FOXP4、LARP1B、OR6X1、S100A5、TMX1、AMBN、CLCC1、FOXQ1、LARP4、OR6Y1、S100A6、TMX2、AMBP、CLCF1、FOXR1、LARP4B、OR7A10、S100A7、TMX3、AMBRA1、CLCN1、FOXR2、LARP6、OR7A17、S100A7A、TMX4、AMD1、CLCN2、FOXRED1、LARP7、OR7A5、S100A7L2、TNC、AMDHD1、CLCN3、FOXRED2、LARS、OR7C1、S100A8、TNF、AMDHD2、CLCN4、FOXS1、LARS2、OR7C2、S100A9、TNFAIP1、AMELX、CLCN5、FPGS、LAS1L、OR7D2、S100B、TNFAIP2、AMELY、CLCN6、FPGT、LASP1、OR7D4、S100G、TNFAIP3、AMER1、CLCN7、FPGT-TNNI3K、LAT、OR7E24、S100P、TNFAIP6、AMER2、CLCNKA、FPR1、LAT2、OR7G1、S100PBP、TNFAIP8、AMER3、CLCNKB、FPR2、LATS1、OR7G2、S100Z、TNFAIP8L1、AMFR、CLDN1、FPR3、LATS2、OR7G3、S1PR1、TNFAIP8L2、AMH、CLDN10、FRA10AC1、LAX1、OR8A1、S1PR2、TNFAIP8L2-SCNM1、AMHR2、CLDN11、FRAS1、LAYN、OR8B12、S1PR3、TNFAIP8L3、AMICA1、CLDN12、FRAT1、LBH、OR8B2、S1PR4、TNFRSF10A、AMIGO1、CLDN14、FRAT2、LBP、OR8B3、S1PR5、TNFRSF10B、AMIGO2、CLDN15、FREM1、LBR、OR8B4、SAA1、TNFRSF10C、AMIGO3、CLDN16、FREM2、LBX1、OR8B8、SAA2、TNFRSF10D、AMMECR1、CLDN17、FREM3、LBX2、OR8D1、SAA2-SAA4、TNFRSF11A、AMMECR1L、CLDN18、FRG1、LCA5、OR8D2、SAA4、TNFRSF11B、AMN、CLDN19、FRG2、LCA5L、OR8D4、SAAL1、TNFRSF12A、AMN1、CLDN2、FRG2B、LCAT、OR8G1、SAC3D1、TNFRSF13B、AMOT、CLDN20、FRG2C、LCE1A、OR8G2、SACM1L、TNFRSF13C、AMOTL1、CLDN22、FRK、LCE1B、OR8G5、SACS、TNFRSF14、AMOTL2、CLDN23、FRMD1、LCE1C、OR8H1、SAE1、TNFRSF17、AMPD1、CLDN24、FRMD3、LCE1D、OR8H2、SAFB、TNFRSF18、AMPD2、CLDN25、FRMD4A、LCE1E、OR8H3、SAFB2、TNFRSF19、AMPD3、CLDN3、FRMD4B、LCE1F、OR8I2、SAG、TNFRSF1A、AMPH、CLDN4、FRMD5、LCE2A、OR8J1、SAGE1、TNFRSF1B、AMT、CLDN5、FRMD6、LCE2B、OR8J3、SALL1、TNFRSF21、AMTN、CLDN6、FRMD7、LCE2C、OR8K1、SALL2、TNFRSF25、AMY1A、CLDN7、FRMD8、LCE2D、OR8K3、
SALL3、TNFRSF4、AMY1B、CLDN8、FRMPD1、LCE3A、OR8K5、SALL4、TNFRSF6B、AMY1C、CLDN9、FRMPD2、LCE3B、OR8S1、SAMD1、TNFRSF8、AMY2A、CLDND1、FRMPD3、LCE3C、OR8U1、SAMD10、TNFRSF9、AMY2B、CLDND2、FRMPD4、LCE3D、OR8U8、SAMD11、TNFSF10、AMZ1、CLEC10A、FRRS1、LCE3E、OR9A2、SAMD12、TNFSF11、AMZ2、CLEC11A、FRRS1L、LCE4A、OR9A4、SAMD13、TNFSF12、ANAPC1、CLEC12A、FRS2、LCE5A、OR9G1、SAMD14、TNFSF12-TNFSF13、ANAPC10、CLEC12B、FRS3、LCE6A、OR9G4、SAMD15、TNFSF13、ANAPC11、CLEC14A、FRY、LCK、OR9G9、SAMD3、TNFSF13B、ANAPC13、CLEC16A、FRYL、LCLAT1、OR9I1、SAMD4A、TNFSF14、ANAPC15、CLEC17A、FRZB、LCMT1、OR9K2、SAMD4B、TNFSF15、ANAPC16、CLEC18A、FSBP、LCMT2、OR9Q1、SAMD5、TNFSF18、ANAPC2、CLEC18B、FSCB、LCN1、OR9Q2、SAMD7、TNFSF4、ANAPC4、CLEC18C、FSCN1、LCN10、ORAI1、SAMD8、TNFSF8、ANAPC5、CLEC19A、FSCN2、LCN12、ORAI2、SAMD9、TNFSF9、ANAPC7、CLEC1A、FSCN3、LCN15、ORAI3、SAMD9L、TNIK、ANG、CLEC1B、FSD1、LCN2、ORAOV1、SAMHD1、TNIP1、ANGEL1、CLEC2A、FSD1L、LCN6、ORC1、SAMM50、TNIP2、ANGEL2、CLEC2B、FSD2、LCN8、ORC2、SAMSN1、TNIP3、ANGPT1、CLEC2D、FSHB、LCN9、ORC3、SAP130、TNK1、ANGPT2、CLEC2L、FSHR、LCNL1、ORC4、SAP18、TNK2、ANGPT4、CLEC3A、FSIP1、LCOR、ORC5、SAP25、TNKS、ANGPTL1、CLEC3B、FSIP2、LCORL、ORC6、SAP30、TNKS1BP1、ANGPTL2、CLEC4A、FST、LCP1、ORM1、SAP30BP、TNKS2、ANGPTL3、CLEC4C、FSTL1、LCP2、ORM2、SAP30L、TNMD、ANGPTL4、CLEC4D、FSTL3、LCT、ORMDL1、SAPCD1、TNN、ANGPTL5、CLEC4E、FSTL4、LCTL、ORMDL2、SAPCD2、TNNC1、ANGPTL6、CLEC4F、FSTL5、LDB1、ORMDL3、SAR1A、TNNC2、ANGPTL7、CLEC4G、FTCD、LDB2、OS9、SAR1B、TNNI1、ANHX、CLEC4M、FTH1、LDB3、OSBP、SARDH、TNNI2、ANK1、CLEC5A、FTH1P18、LDHA、OSBP2、SARM1、TNNI3、ANK2、CLEC6A、FTHL17、LDHAL6A、OSBPL10、SARNP、TNNI3K、ANK3、CLEC7A、FTL、LDHAL6B、OSBPL11、SARS、TNNT1、ANKAR、CLEC9A、FTMT、LDHB、OSBPL1A、SARS2、TNNT2、ANKDD1A、CLECL1、FTO、LDHC、OSBPL2、SART1、TNNT3、ANKDD1B、CLGN、FTSJ1、LDHD、OSBPL3、SART3、TNP1、ANKEF1、CLHC1、FTSJ2、LDLR、OSBPL5、SASH1、TNP2、ANKFN1、CLIC1、FTSJ3、LDLRAD1、OSBPL6、SASH3、TNPO1、ANKFY1、CLIC2、FUBP1、LDLRAD2、OSBPL7、SASS6、TNPO2、ANKH、CLIC3、FUBP3、LDLRAD3、OSBPL8、SAT1、TNPO3、ANKHD1、CLIC4、FUCA1、LDLRAD4、OSBPL9、SAT2、TNR、ANKHD1-EIF4EBP3、CLIC5、FUCA2、LDLRAP1、OSCAR、SATB1、TNRC18、ANKIB1、CLIC6、FUK、LDOC1、OSCP1、SATB2、TNRC6A、ANKK1、CLINT1、FUNDC1、LDOC1L、OSER1、SATL1、TNRC6B、ANKLE1、CLIP1、FUNDC2、LEAP2、OSGEP、SAV1、TNRC6C、ANKLE2、CLIP2、FUOM、LECT1、OSGEPL1、SAYSD1、TNS1、ANKMY1、CLIP3、FURIN、LECT2、OSGIN1、SBDS、TNS3、ANKMY2、CLIP4、FUS、LEF1、OSGIN2、SBF1、TNS4、ANKRA2、CLK1、FUT1、leftY1、OSM、SBF2、TNXB、ANKRD1、CLK2、FUT10、leftY2、OSMR、SBK1、TOB1、ANKRD10、CLK3、FUT11、LEKR1、OSR1、SBK2、TOB2、ANKRD11、CLK4、FUT2、LELP1、OSR2、SBK3、TOE1、ANKRD12、CLLU1、FUT3、LEMD1、OST4、SBNO1、TOLLIP、ANKRD13A、CLLU1OS、FUT4、LEMD2、OSTC、SBNO2、TOM1、ANKRD13B、CLMN、FUT5、LEMD3、OSTF1、SBSN、TOM1L1、ANKRD13C、CLMP、FUT6、LENEP、OSTM1、SBSPON、TOM1L2、ANKRD13D、CLN3、FUT7、LENG1、OSTN、SC5D、TOMM20、
	ANKRD16、CLN5、FUT8、LENG8、OTC、SCAF1、TOMM20L、ANKRD17、CLN6、FUT9、LENG9、OTOA、SCAF11、TOMM22、ANKRD18A、CLN8、FUZ、LEO1、OTOF、SCAF4、TOMM34、ANKRD18B、CLNK、FXN、LEP、OTOG、SCAF8、TOMM40、ANKRD2、CLNS1A、FXR1、LEPR、OTOGL、SCAI、TOMM40L、ANKRD20A1、CLOCK、FXR2、LEPRE1、OTOL1、SCAMP1、TOMM5、ANKRD20A2、CLP1、FXYD1、LEPREL1、Otop1、SCAMP2、TOMM6、ANKRD20A3、CLPB、FXYD2、LEPREL2、Otop2、SCAMP3、TOMM7、ANKRD20A4、CLPP、FXYD3、LEPREL4、Otop3、SCAMP4、TOMM70A、ANKRD22、CLPS、FXYD4、LEPROT、OTOR、SCAMP5、TONSL、ANKRD23、CLPSL1、FXYD5、LEPROTL1、OTOS、SCAND1、top1、ANKRD24、CLPSL2、FXYD6、LETM1、OTP、SCAND3、top1MT、ANKRD26、CLPTM1、FXYD6-FXYD2、LETM2、OTUB1、SCAP、top2A、ANKRD27、CLPTM1L、FXYD7、LETMD1、OTUB2、SCAPER、top2B、ANKRD28、CLPX、FYB、LEUTX、OTUD1、SCARA3、top3A、ANKRD29、CLRN1、FYCO1、LFNG、OTUD3、SCARA5、top3B、ANKRD30A、CLRN2、FYN、LGALS1、OTUD4、SCARB1、topAZ1、ANKRD30B、CLRN3、FYTTD1、LGALS12、OTUD5、SCARB2、topBP1、ANKRD31、CLSPN、FZD1、LGALS13、OTUD6A、SCARF1、topORS、ANKRD32、CLSTN1、FZD10、LGALS14、OTUD6B、SCARF2、TOR1A、ANKRD33、CLSTN2、FZD2、LGALS16、OTUD7A、SCCPDH、TOR1AIP1、ANKRD33B、CLSTN3、FZD3、LGALS2、OTUD7B、SCD、TOR1AIP2、ANKRD34A、CLTA、FZD4、LGALS3、OTX1、SCD5、TOR1B、ANKRD34B、CLTB、FZD5、LGALS3BP、OTX2、SCEL、TOR2A、ANKRD34C、CLTC、FZD6、LGALS4、OVCA2、SCFD1、TOR3A、ANKRD35、CLTCL1、FZD7、LGALS7、OVCH1、SCFD2、TOR4A、ANKRD36、CLU、FZD8、LGALS7B、OVCH2、SCG2、TOX、ANKRD36B、CLUAP1、FZD9、LGALS8、OVGP1、SCG3、TOX2、ANKRD36C、CLUH、FZR1、LGALS9、OVOL1、SCG5、TOX3、ANKRD37、CLUL1、G0S2、LGALS9B、OVOL2、SCGB1A1、TOX4、ANKRD39、CLVS1、G2E3、LGALS9C、OVOL3、SCGB1C1、TP53、ANKRD40、CLVS2、G3BP1、LGALSL、OVOS、SCGB1D1、TP53AIP1、ANKRD42、CLYBL、G3BP2、LGI1、OVOS2、SCGB1D2、TP53BP1、ANKRD44、CMA1、G6PC、LGI2、OXA1L、SCGB1D4、TP53BP2、ANKRD45、CMAS、G6PC2、LGI3、OXCT1、SCGB2A1、TP53I11、ANKRD46、CMBL、G6PC3、LGI4、OXCT2、SCGB2A2、TP53I13、ANKRD49、CMC1、G6PD、LGMN、OXER1、SCGB2B2、TP53I3、ANKRD50、CMC2、GAA、LGR4、OXGR1、SCGB3A1、TP53INP1、ANKRD52、CMC4、GAB1、LGR5、OXLD1、SCGB3A2、TP53INP2、ANKRD53、CMIP、GAB2、LGR6、OXNAD1、SCGN、TP53RK、ANKRD54、CMKLR1、GAB3、LGSN、OXR1、SCHIP1、TP53TG3、ANKRD55、CMPK1、GAB4、LHB、OXSM、SCIMP、TP53TG3B、ANKRD6、CMPK2、GABARAP、LHCGR、OXSR1、SCIN、TP53TG3C、ANKRD60、CMSS1、GABARAPL1、LHFP、OXT、SCLT1、TP53TG3D、ANKRD61、CMTM1、GABARAPL2、LHFPL1、OXTR、SCLY、TP53TG5、ANKRD62、CMTM2、GABBR1、LHFPL2、P2RX1、SCMH1、TP63、ANKRD63、CMTM3、GABBR2、LHFPL3、P2RX2、SCML1、TP73、ANKRD65、CMTM4、GABPA、LHFPL4、P2RX3、SCML2、TPBG、ANKRD66、CMTM5、GABPB1、LHFPL5、P2RX4、SCML4、TPBGL、ANKRD7、CMTM6、GABPB2、LHPP、P2RX5、SCN10A、TPCN1、ANKRD9、CMTM7、GABRA1、LHX1、P2RX6、SCN11A、TPCN2、ANKS1A、CMTM8、GABRA2、LHX2、P2RX7、SCN1A、TPD52、ANKS1B、CMTR1、GABRA3、LHX3、P2RY1、SCN1B、TPD52L1、ANKS3、CMTR2、GABRA4、LHX4、P2RY10、SCN2A、TPD52L2、ANKS4B、CMYA5、GABRA5、LHX5、P2RY11、SCN2B、TPD52L3、ANKS6、CNBD1、GABRA6、LHX6、
P2RY12、SCN3A、TPGS1、ANKUB1、CNBD2、GABRB1、LHX8、P2RY13、SCN3B、TPGS2、ANKZF1、CNBP、GABRB2、LHX9、P2RY14、SCN4A、TPH1、ANLN、CNDP1、GABRB3、LIAS、P2RY2、SCN4B、TPH2、ANO1、CNDP2、GABRD、LIF、P2RY4、SCN5A、TPI1、ANO10、CNEP1R1、GABRE、LIFR、P2RY6、SCN7A、TPK1、ANO2、CNFN、GABRG1、LIG1、P2RY8、SCN8A、TPM1、ANO3、CNGA1、GABRG2、LIG3、P4HA1、SCN9A、TPM2、ANO4、CNGA2、GABRG3、LIG4、P4HA2、SCNM1、TPM3、ANO5、CNGA3、GABRP、LILRA1、P4HA3、SCNN1A、TPM4、ANO6、CNGA4、GABRQ、LILRA2、P4HB、SCNN1B、TPMT、ANO7、CNGB1、GABRR1、LILRA3、P4HTM、SCNN1D、TPO、ANO8、CNGB3、GABRR2、LILRA4、PA2G4、SCNN1G、TPP1、ANO9、CNIH1、GABRR3、LILRA5、PAAF1、SCO1、TPP2、ANP32A、CNIH2、GAD1、LILRA6、PABPC1、SCO2、TPPP、ANP32B、CNIH3、GAD2、LILRB1、PABPC1L、SCOC、TPPP2、ANP32C、CNIH4、GADD45A、LILRB2、PABPC1L2A、SCP2、TPPP3、ANP32D、CNKSR1、GADD45B、LILRB3、PABPC1L2B、SCP2D1、TPR、ANP32E、CNKSR2、GADD45G、LILRB4、PABPC3、SCPEP1、TPRA1、ANPEP、CNKSR3、GADD45GIP1、LILRB5、PABPC4、SCRG1、TPRG1、ANTXR1、CNN1、GADL1、LIM2、PABPC4L、SCRIB、TPRG1L、ANTXR2、CNN2、GAGE1、LIMA1、PABPC5、SCRN1、TPRKB、ANTXRL、CNN3、GAGE10、LIMCH1、PABPN1、SCRN2、TPRN、ANXA1、CNNM1、GAGE12B、LIMD1、PABPN1L、SCRN3、TPRX1、ANXA10、CNNM2、GAGE12C、LIMD2、PACRG、SCRT1、TPSAB1、ANXA11、CNNM3、GAGE12D、LIME1、PACRGL、SCRT2、TPSB2、ANXA13、CNNM4、GAGE12E、LIMK1、PACS1、SCT、TPSD1、ANXA2、CNOT1、GAGE12F、LIMK2、PACS2、SCTR、TPSG1、ANXA2R、CNOT10、GAGE12G、LIMS1、PACSIN1、SCUBE1、TPST1、ANXA3、CNOT11、GAGE12H、LIMS2、PACSIN2、SCUBE2、TPST2、ANXA4、CNOT2、GAGE12I、LIMS3、PACSIN3、SCUBE3、TPT1、ANXA5、CNOT3、GAGE12J、LIN28A、PADI1、SCXA、TPTE、ANXA6、CNOT4、GAGE13、LIN28B、PADI2、SCXB、TPTE2、ANXA7、CNOT6、GAGE2A、LIN37、PADI3、SCYL1、TPX2、ANXA8、CNOT6L、GAGE2B、LIN52、PADI4、SCYL2、TRA2A、ANXA8L1、CNOT7、GAGE2C、LIN54、PADI6、SCYL3、TRA2B、ANXA8L2、CNOT8、GAGE2D、LIN7A、PAEP、SDAD1、TRABD、ANXA9、CNP、GAGE2E、LIN7B、PAF1、SDC1、TRABD2A、AOAH、CNPPD1、GAGE4、LIN7C、PAFAH1B1、SDC2、TRABD2B、AOC1、CNPY1、GAGE5、LIN9、PAFAH1B2、SDC3、TRADD、AOC2、CNPY2、GAGE6、LINC00452、PAFAH1B3、SDC4、TRAF1、AOC3、CNPY3、GAGE7、LINC00984、PAFAH2、SDCBP、TRAF2、AOX1、CNPY4、GAGE8、LINGO1、PAG1、SDCBP2、TRAF3、AP1AR、CNR1、GAK、LINGO2、PAGE1、SDCCAG3、TRAF3IP1、AP1B1、CNR2、GAL、LINGO3、PAGE2、SDCCAG8、TRAF3IP2、AP1G1、CNRIP1、GAL3ST1、LINGO4、PAGE2B、SDE2、TRAF3IP3、AP1G2、CNST、GAL3ST2、LINS、PAGE4、SDF2、TRAF4、AP1M1、CNTD1、GAL3ST3、LIPA、PAGE5、SDF2L1、TRAF5、AP1M2、CNTD2、GAL3ST4、LIPC、PAGR1、SDF4、TRAF6、AP1S1、CNTF、GALC、LIPE、PAH、SDHA、TRAF7、AP1S2、CNTFR、GALE、LIPF、PAICS、SDHAF1、TRAFD1、AP1S3、CNTLN、GALK1、LIPG、PAIP1、SDHAF2、TRAIP、AP2A1、CNTN1、GALK2、LIPH、PAIP2、SDHB、TRAK1、AP2A2、CNTN2、GALM、LIPI、PAIP2B、SDHC、TRAK2、AP2B1、CNTN3、GALNS、LIPJ、PAK1、SDHD、TRAM1、AP2M1、CNTN4、GALNT1、LIPK、PAK1IP1、SDK1、TRAM1L1、AP2S1、CNTN5、GALNT10、LIPM、PAK2、SDK2、TRAM2、AP3B1、CNTN6、GALNT11、LIPN、PAK3、SDPR、TRANK1、AP3B2、CNTNAP1、GALNT12、LIPT1、PAK4、SDR16C5、TRAP1、
	AP3D1、CNTNAP2、GALNT13、LIPT2、PAK6、SDR39U1、TRAPPC1、AP3M1、CNTNAP3、GALNT14、LITAF、PAK7、SDR42E1、TRAPPC10、AP3M2、CNTNAP3B、GALNT15、LIX1、PALB2、SDR9C7、TRAPPC11、AP3S1、CNTNAP4、GALNT16、LIX1L、PALD1、SDS、TRAPPC12、AP3S2、CNTNAP5、GALNT18、LLGL1、PALLD、SDSL、TRAPPC13、AP4B1、CNTRL、GALNT2、LLGL2、PALM、SEBOX、TRAPPC2、AP4E1、CNTROB、GALNT3、LLPH、PALM2、SEC11A、TRAPPC2L、AP4M1、COA1、GALNT4、LMAN1、PALM2-AKAP2、SEC11C、TRAPPC3、AP4S1、COA3、GALNT5、LMAN1L、PALM3、SEC13、TRAPPC3L、AP5B1、COA4、GALNT6、LMAN2、PALMD、SEC14L1、TRAPPC4、AP5M1、COA5、GALNT7、LMAN2L、PAM、SEC14L2、TRAPPC5、AP5S1、COA6、GALNT8、LMBR1、PAM16、SEC14L3、TRAPPC6A、AP5Z1、COASY、GALNT9、LMBR1L、PAMR1、SEC14L4、TRAPPC6B、APAF1、COBL、GALNTL5、LMBRD1、PAN2、SEC14L5、TRAPPC8、APBA1、COBLL1、GALNTL6、LMBRD2、PAN3、SEC14L6、TRAPPC9、APBA2、COCH、GALP、LMCD1、PANK1、SEC16A、TRAT1、APBA3、COG1、GALR1、LMF1、PANK2、SEC16B、TRDMT1、APBB1、COG2、GALR2、LMF2、PANK3、SEC22A、TRDN、APBB1IP、COG3、GALR3、LMLN、PANK4、SEC22B、TREH、APBB2、COG4、GALT、LMNA、PANX1、SEC22C、TREM1、APBB3、COG5、GAMT、LMNB1、PANX2、SEC23A、TREM2、APC、COG6、GAN、LMNB2、PANX3、SEC23B、TREML1、APC2、COG7、GANAB、LMO1、PAOX、SEC23IP、TREML2、APCDD1、COG8、GANC、LMO2、PAPD4、SEC24A、TREML4、APCDD1L、COIL、GAP43、LMO3、PAPD5、SEC24B、TRERF1、APCS、COL10A1、GAPDH、LMO4、PAPD7、SEC24C、TREX1、APEH、COL11A1、GAPDHS、LMO7、PAPL、SEC24D、TREX2、APEX1、COL11A2、GAPT、LMOD1、PAPLN、SEC31A、TRH、APEX2、COL12A1、GAPVD1、LMOD2、PAPOLA、SEC31B、TRHDE、APH1A、COL13A1、GAR1、LMOD3、PAPOLB、SEC61A1、TRHR、APH1B、COL14A1、GAREM、LMTK2、PAPOLG、SEC61A2、TRIAP1、API5、COL15A1、GAREML、LMTK3、PAPPA、SEC61B、TRIB1、APIP、COL16A1、GARNL3、LMX1A、PAPPA2、SEC61G、TRIB2、APITD1、COL17A1、GARS、LMX1B、PAPSS1、SEC62、TRIB3、APITD1-CORT、COL18A1、GART、LNP1、PAPSS2、SEC63、TRIL、APLF、COL19A1、GAS1、LNPEP、PAQR3、SECISBP2、TRIM10、APLN、COL1A1、GAS2、LNX1、PAQR4、SECISBP2L、TRIM11、APLNR、COL1A2、GAS2L1、LNX2、PAQR5、SECTM1、TRIM13、APLP1、COL20A1、GAS2L2、LOH12CR1、PAQR6、SEH1L、TRIM14、APLP2、COL21A1、GAS2L3、LONP1、PAQR7、SEL1L、TRIM15、APMAP、COL22A1、GAS6、LONP2、PAQR8、SEL1L2、TRIM16、APOA1、COL23A1、GAS7、LONRF1、PAQR9、SEL1L3、TRIM16L、APOA1BP、COL24A1、GAS8、LONRF2、PARD3、SELE、TRIM17、APOA2、COL25A1、GAST、LONRF3、PARD3B、SELENBP1、TRIM2、APOA4、COL26A1、GATA1、LOR、PARD6A、SELK、TRIM21、APOA5、COL27A1、GATA2、LOX、PARD6B、SELL、TRIM22、APOB、COL28A1、GATA3、LOXHD1、PARD6G、SELM、TRIM23、APOBEC1、COL2A1、GATA4、LOXL1、PARG、SELO、TRIM24、APOBEC2、COL3A1、GATA5、LOXL2、PARK2、SELP、TRIM25、APOBEC3A、COL4A1、GATA6、LOXL3、PARK7、SELPLG、TRIM26、APOBEC3B、COL4A2、GATAD1、LOXL4、PARL、SELRC1、TRIM27、APOBEC3C、COL4A3、GATAD2A、LPA、PARM1、SELT、TRIM28、APOBEC3D、COL4A3BP、GATAD2B、LPAR1、PARN、SELV、TRIM29、APOBEC3F、COL4A4、GATC、LPAR2、PARP1、SEMA3A、TRIM3、APOBEC3G、COL4A5、GATM、LPAR3、PARP10、SEMA3B、TRIM31、APOBEC3H、COL4A6、GATS、LPAR4、
PARP11、SEMA3C、TRIM32、APOBEC4、COL5A1、GATSL1、LPAR5、PARP12、SEMA3D、TRIM33、APOBR、COL5A2、GATSL2、LPAR6、PARP14、SEMA3E、TRIM34、APOC1、COL5A3、GATSL3、LPCAT1、PARP15、SEMA3F、TRIM35、APOC2、COL6A1、GBA、LPCAT2、PARP16、SEMA3G、TRIM36、APOC3、COL6A2、GBA2、LPCAT3、PARP2、SEMA4A、TRIM37、APOC4、COL6A3、GBA3、LPCAT4、PARP3、SEMA4B、TRIM38、APOD、COL6A5、GBAS、LPGAT1、PARP4、SEMA4C、TRIM39、APOE、COL6A6、GBE1、LPHN1、PARP6、SEMA4D、TRIM39-RPP21、APOF、COL7A1、GBF1、LPHN2、PARP8、SEMA4F、TRIM4、APOH、COL8A1、GBGT1、LPHN3、PARP9、SEMA4G、TRIM40、APOL1、COL8A2、GBP1、LPIN1、PARPBP、SEMA5A、TRIM41、APOL2、COL9A1、GBP2、LPIN2、PARS2、SEMA5B、TRIM42、APOL3、COL9A2、GBP3、LPIN3、PARVA、SEMA6A、TRIM43、APOL4、COL9A3、GBP4、LPL、PARVB、SEMA6B、TRIM43B、APOL5、COLCA2、GBP5、LPO、PARVG、SEMA6C、TRIM44、APOL6、COLEC10、GBP6、LPP、PASD1、SEMA6D、TRIM45、APOLD1、COLEC11、GBP7、LPPR1、PASK、SEMA7A、TRIM46、APOM、COLEC12、GBX1、LPPR2、PATE1、SEMG1、TRIM47、APOO、COLGALT1、GBX2、LPPR3、PATE2、SEMG2、TRIM48、APOOL、COLGALT2、GC、LPPR4、PATE3、SENP1、TRIM49、APOPT1、COLQ、GCA、LPPR5、PATE4、SENP2、TRIM49B、APP、COMMD1、GCAT、LPXN、PATL1、SENP3、TRIM49C、APPBP2、COMMD10、GCC1、LRAT、PATL2、SENP5、TRIM49D1、APPL1、COMMD2、GCC2、LRBA、PATZ1、SENP6、TRIM49D2P、APPL2、COMMD3、GCDH、LRCH1、PAWR、SENP7、TRIM5、APRT、COMMD3-BMI1、GCFC2、LRCH2、PAX1、SENP8、TRIM50、APTX、COMMD4、GCG、LRCH3、PAX2、SEPHS1、TRIM51、AQP1、COMMD5、GCGR、LRCH4、PAX3、SEPHS2、TRIM52、AQP10、COMMD6、GCH1、LRCOL1、PAX4、SEPN1、TRIM54、AQP11、COMMD7、GCHFR、LRFN1、PAX5、SEPP1、TRIM55、AQP12A、COMMD8、GCK、LRFN2、PAX6、SEPSECS、TRIM56、AQP12B、COMMD9、GCKR、LRFN3、PAX7、SEPT1、TRIM58、AQP2、COMP、GCLC、LRFN4、PAX8、SEPT10、TRIM59、AQP3、COMT、GCLM、LRFN5、PAX9、SEPT11、TRIM6、AQP4、COMTD1、GCM1、LRG1、PAXBP1、SEPT12、TRIM60、AQP5、COPA、GCM2、LRGUK、PAXIP1、SEPT14、TRIM61、AQP6、COPB1、GCN1L1、LRIF1、PBDC1、SEPT15、TRIM62、AQP7、COPB2、GCNT1、LRIG1、PBK、SEPT2、TRIM63、AQP8、COPE、GCNT2、LRIG2、PBLD、SEPT3、TRIM64、AQP9、COPG1、GCNT3、LRIG3、PBOV1、SEPT4、TRIM64B、AQPEP、COPG2、GCNT4、LRIT1、PBRM1、SEPT5、TRIM64C、AQR、COPRS、GCNT7、LRIT2、PBX1、SEPT6、TRIM65、AR、COPS2、GCOM1、LRIT3、PBX2、SEPT7、TRIM66、ARAF、COPS3、GCSAM、LRMP、PBX3、SEPT8、TRIM67、ARAP1、COPS4、GCSAML、LRP1、PBX4、SEPT9、TRIM68、ARAP2、COPS5、GCSH、LRP10、PBXIP1、SEPW1、TRIM69、ARAP3、COPS6、GDA、LRP11、PC、SERAC1、TRIM6-TRIM34、ARC、COPS7A、GDAP1、LRP12、PCBD1、SERBP1、TRIM7、ARCN1、COPS7B、GDAP1L1、LRP1B、PCBD2、SERF1A、TRIM71、AREG、COPS8、GDAP2、LRP2、PCBP1、SERF1B、TRIM72、AREGB、COPZ1、GDE1、LRP2BP、PCBP2、SERF2、TRIM73、AREL1、COPZ2、GDF1、LRP3、PCBP3、SERGEF、TRIM74、ARF1、COQ10A、GDF10、LRP4、PCBP4、SERHL2、TRIM77、ARF3、COQ10B、GDF11、LRP5、PCCA、SERINC1、TRIM8、ARF4、COQ2、GDF15、LRP5L、PCCB、SERINC2、TRIM9、ARF5、COQ3、GDF2、LRP6、PCDH1、SERINC3、TRIML1、ARF6、COQ4、GDF3、LRP8、PCDH10、SERINC4、TRIML2、ARFGAP1、COQ5、GDF5、LRPAP1、PCDH11X、SERINC5、TRIO、ARFGAP2、COQ6、GDF6、LRPPRC、
	PCDH11Y、SERP1、TRIOBP、ARFGAP3、COQ7、GDF7、LRR1、PCDH12、SERP2、TRIP10、ARFGEF1、COQ9、GDF9、LRRC1、PCDH15、SERPINA1、TRIP11、ARFGEF2、CORIN、GDI1、LRRC10、PCDH17、SERPINA10、TRIP12、ARFIP1、CORO1A、GDI2、LRRC10B、PCDH18、SERPINA11、TRIP13、ARFIP2、CORO1B、GDNF、LRRC14、PCDH19、SERPINA12、TRIP4、ARFRP1、CORO1C、GDNF-AS1、LRRC14B、PCDH20、SERPINA3、TRIP6、ARG1、CORO2A、GDPD1、LRRC15、PCDH7、SERPINA4、TRIQK、ARG2、CORO2B、GDPD2、LRRC16A、PCDH8、SERPINA5、TRIT1、ARGFX、CORO6、GDPD3、LRRC16B、PCDH9、SERPINA6、TRMT1、ARGLU1、CORO7、GDPD4、LRRC17、PCDHA1、SERPINA7、TRMT10A、ARHGAP1、CORO7-PAM16、GDPD5、LRRC18、PCDHA10、SERPINA9、TRMT10B、ARHGAP10、CORT、GDPGP1、LRRC19、PCDHA11、SERPINB1、TRMT10C、ARHGAP11A、COTL1、GEM、LRRC2、PCDHA12、SERPINB10、TRMT11、ARHGAP11B、COX10、GEMIN2、LRRC20、PCDHA13、SERPINB11、TRMT112、ARHGAP12、COX11、GEMIN4、LRRC23、PCDHA2、SERPINB12、TRMT12、ARHGAP15、COX14、GEMIN5、LRRC24、PCDHA3、SERPINB13、TRMT13、ARHGAP17、COX15、GEMIN6、LRRC25、PCDHA4、SERPINB2、TRMT1L、ARHGAP18、COX16、GEMIN7、LRRC26、PCDHA5、SERPINB3、TRMT2A、ARHGAP19、COX17、GEMIN8、LRRC27、PCDHA6、SERPINB4、TRMT2B、ARHGAP20、COX18、GEN1、LRRC28、PCDHA7、SERPINB5、TRMT44、ARHGAP21、COX19、GET4、LRRC29、PCDHA8、SERPINB6、TRMT5、ARHGAP22、COX20、GFAP、LRRC3、PCDHA9、SERPINB7、TRMT6、ARHGAP23、COX4I1、GFER、LRRC30、PCDHAC1、SERPINB8、TRMT61A、ARHGAP24、COX4I2、GFI1、LRRC31、PCDHAC2、SERPINB9、TRMT61B、ARHGAP25、COX5A、GFI1B、LRRC32、PCDHB1、SERPINC1、TRMU、ARHGAP26、COX5B、GFM1、LRRC34、PCDHB10、SERPIND1、TRNAU1AP、ARHGAP27、COX6A1、GFM2、LRRC36、PCDHB11、SERPINE1、TRNP1、ARHGAP28、COX6A2、GFOD1、LRRC37A2、PCDHB12、SERPINE2、TRNT1、ARHGAP29、COX6B1、GFOD2、LRRC37A3、PCDHB13、SERPINE3、TRO、ARHGAP30、COX6B2、GFPT1、LRRC37B、PCDHB14、SERPINF1、TROAP、ARHGAP31、COX6C、GFPT2、LRRC38、PCDHB15、SERPINF2、TROVE2、ARHGAP32、COX7A1、GFRA1、LRRC39、PCDHB16、SERPING1、TRPA1、ARHGAP33、COX7A2、GFRA2、LRRC3B、PCDHB2、SERPINH1、TRPC1、ARHGAP35、COX7A2L、GFRA3、LRRC3C、PCDHB3、SERPINI1、TRPC3、ARHGAP36、COX7B、GFRA4、LRRC4、PCDHB4、SERPINI2、TRPC4、ARHGAP39、COX7B2、GFRAL、LRRC40、PCDHB5、SERTAD1、TRPC4AP、ARHGAP4、COX7C、GGA1、LRRC41、PCDHB6、SERTAD2、TRPC5、ARHGAP40、COX8A、GGA2、LRRC42、PCDHB7、SERTAD3、TRPC5OS、ARHGAP42、COX8C、GGA3、LRRC43、PCDHB8、SERTAD4、TRPC6、ARHGAP44、CP、GGACT、LRRC45、PCDHB9、SERTM1、TRPC7、ARHGAP5、CPA1、GGCT、LRRC46、PCDHGA1、SESN1、TRPM1、ARHGAP6、CPA2、GGCX、LRRC47、PCDHGA10、SESN2、TRPM2、ARHGAP8、CPA3、GGH、LRRC48、PCDHGA11、SESN3、TRPM3、ARHGAP9、CPA4、GGN、LRRC49、PCDHGA12、SESTD1、TRPM4、ARHGDIA、CPA5、GGNBP2、LRRC4B、PCDHGA2、SET、TRPM5、ARHGDIB、CPA6、GGPS1、LRRC4C、PCDHGA3、SETBP1、TRPM6、ARHGDIG、CPAMD8、GGT1、LRRC52、PCDHGA4、SETD1A、TRPM7、ARHGEF1、CPB1、GGT2、LRRC55、PCDHGA5、SETD1B、TRPM8、ARHGEF10、CPB2、GGT5、LRRC56、PCDHGA6、SETD2、TRPS1、ARHGEF10L、CPD、GGT6、LRRC57、PCDHGA7、SETD3、TRPT1、ARHGEF11、CPE、GGT7、LRRC58、PCDHGA8、SETD4、
TRPV1、ARHGEF12、CPEB1、GGTLC1、LRRC59、PCDHGA9、SETD5、TRPV2、ARHGEF15、CPEB2、GGTLC2、LRRC6、PCDHGB1、SETD6、TRPV3、ARHGEF16、CPEB3、GH1、LRRC61、PCDHGB2、SETD7、TRPV4、ARHGEF17、CPEB4、GH2、LRRC63、PCDHGB3、SETD8、TRPV5、ARHGEF18、CPED1、GHDC、LRRC66、PCDHGB4、SETD9、TRPV6、ARHGEF19、CPLX1、GHITM、LRRC69、PCDHGB5、SETDB1、TRRAP、ARHGEF2、CPLX2、GHR、LRRC7、PCDHGB6、SETDB2、TRUB1、ARHGEF25、CPLX3、GHRH、LRRC70、PCDHGB7、SETMAR、TRUB2、ARHGEF26、CPLX4、GHRHR、LRRC71、PCDHGC3、SETSIP、TSACC、ARHGEF28、CPM、GHRL、LRRC72、PCDHGC4、SETX、TSC1、ARHGEF3、CPN1、GHSR、LRRC73、PCDHGC5、SEZ6、TSC2、ARHGEF33、CPN2、GID4、LRRC8A、PCDP1、SEZ6L、TSC22D1、ARHGEF35、CPNE1、GID8、LRRC8B、PCED1A、SEZ6L2、TSC22D2、ARHGEF37、CPNE2、GIF、LRRC8C、PCED1B、SF1、TSC22D3、ARHGEF38、CPNE3、GIGYF1、LRRC8D、PCF11、SF3A1、TSC22D4、ARHGEF39、CPNE4、GIGYF2、LRRC8E、PCGF1、SF3A2、TSEN15、ARHGEF4、CPNE5、GIMAP1、LRRCC1、PCGF2、SF3A3、TSEN2、ARHGEF40、CPNE6、GIMAP1-GIMAP5、LRRD1、PCGF3、SF3B1、TSEN34、ARHGEF5、CPNE7、GIMAP2、LRRFIP1、PCGF5、SF3B14、TSEN54、ARHGEF6、CPNE8、GIMAP4、LRRFIP2、PCGF6、SF3B2、TSFM、ARHGEF7、CPNE9、GIMAP5、LRRIQ1、PCID2、SF3B3、TSG101、ARHGEF9、CPO、GIMAP6、LRRIQ3、PCIF1、SF3B4、TSGA10、ARID1A、CPOX、GIMAP7、LRRIQ4、PCK1、SF3B5、TSGA10IP、ARID1B、CPPED1、GIMAP8、LRRK1、PCK2、SFI1、TSGA13、ARID2、CPQ、GIMD1、LRRK2、PCLO、SFMBT1、TSHB、ARID3A、CPS1、GIN1、LRRN1、PCM1、SFMBT2、TSHR、ARID3B、CPSF1、GINM1、LRRN2、PCMT1、SFN、TSHZ1、ARID3C、CPSF2、GINS1、LRRN3、PCMTD1、SFPQ、TSHZ2、ARID4A、CPSF3、GINS2、LRRN4、PCMTD2、SFR1、TSHZ3、ARID4B、CPSF3L、GINS3、LRRN4CL、PCNA、SFRP1、TSKS、ARID5A、CPSF4、GINS4、LRRTM1、PCNP、SFRP2、TSKU、ARID5B、CPSF4L、GIP、LRRTM2、PCNT、SFRP4、TSLP、ARIH1、CPSF6、GIPC1、LRRTM3、PCNX、SFRP5、TSN、ARIH2、CPSF7、GIPC2、LRRTM4、PCNXL2、SFSWAP、TSNARE1、ARIH2OS、CPT1A、GIPC3、LRSAM1、PCNXL3、SFT2D1、TSNAX、ARL1、CPT1B、GIPR、LRTM1、PCNXL4、SFT2D2、TSNAXIP1、ARL10、CPT1C、GIT1、LRTM2、PCOLCE、SFT2D3、TSPAN1、ARL11、CPT2、GIT2、LRTOMT、PCOLCE2、SFTA2、TSPAN10、ARL13A、CPVL、GJA1、LRWD1、PCP2、SFTA3、TSPAN11、ARL13B、CPXCR1、GJA10、LSAMP、PCP4、SFTPA1、TSPAN12、ARL14、CPXM1、GJA3、LSG1、PCP4L1、SFTPA2、TSPAN13、ARL14EP、CPXM2、GJA4、LSM1、PCSK1、SFTPB、TSPAN14、ARL14EPL、CPZ、GJA5、LSM10、PCSK1N、SFTPC、TSPAN15、ARL15、CR1、GJA8、LSM11、PCSK2、SFTPD、TSPAN16、ARL16、CR1L、GJA9、LSM12、PCSK4、SFXN1、TSPAN17、ARL17A、CR2、GJB1、LSM14A、PCSK5、SFXN2、TSPAN18、ARL17B、CRABP1、GJB2、LSM14B、PCSK6、SFXN3、TSPAN19、ARL2、CRABP2、GJB3、LSM2、PCSK7、SFXN4、TSPAN2、ARL2BP、CRADD、GJB4、LSM3、PCSK9、SFXN5、TSPAN3、ARL3、CRAMP1L、GJB5、LSM4、PCTP、SGCA、TSPAN31、ARL4A、CRAT、GJB6、LSM5、PCYOX1、SGCB、TSPAN32、ARL4C、CRB1、GJB7、LSM6、PCYOX1L、SGCD、TSPAN33、ARL4D、CRB2、GJC1、LSM7、PCYT1A、SGCE、TSPAN4、ARL5A、CRB3、GJC2、LSMD1、PCYT1B、SGCG、TSPAN5、ARL5B、CRBN、GJC3、LSMEM1、PCYT2、SGCZ、TSPAN6、ARL5C、CRCP、GJD2、LSMEM2、PDAP1、SGIP1、TSPAN7、ARL6、CRCT1、GJD3、LSP1、PDC、SGK1、TSPAN8、ARL6IP1、
	CREB1、GJD4、LSR、PDCD1、SGK2、TSPAN9、ARL6IP4、CREB3、GK、LSS、PDCD10、SGK223、TSPEAR、ARL6IP5、CREB3L1、GK2、LST1、PDCD11、SGK3、TSPO、ARL6IP6、CREB3L2、GK5、LTA、PDCD1LG2、SGK494、TSPO2、ARL8A、CREB3L3、GKAP1、LTA4H、PDCD2、SGMS1、TSPY1、ARL8B、CREB3L4、GKN1、LTB、PDCD2L、SGMS2、TSPY10、ARL9、CREB5、GKN2、LTB4R、PDCD4、SGOL1、TSPY2、ARMC1、CREBBP、GLA、LTB4R2、PDCD5、SGOL2、TSPY3、ARMC10、CREBL2、GLB1、LTBP1、PDCD6、SGPL1、TSPY4、ARMC12、CREBRF、GLB1L、LTBP2、PDCD6IP、SGPP1、TSPY8、ARMC2、CREBZF、GLB1L2、LTBP3、PDCD7、SGPP2、TSPYL1、ARMC3、CREG1、GLB1L3、LTBP4、PDCL、SGSH、TSPYL2、ARMC4、CREG2、GLCCI1、LTBR、PDCL2、SGSM1、TSPYL4、ARMC5、CRELD1、GLCE、LTC4S、PDCL3、SGSM2、TSPYL5、ARMC6、CRELD2、GLDC、LTF、PDDC1、SGSM3、TSPYL6、ARMC7、CREM、GLDN、LTK、PDE10A、SGTA、TSR1、ARMC8、CRH、GLE1、LTN1、PDE11A、SGTB、TSR2、ARMC9、CRHBP、GLG1、LTV1、PDE12、SH2B1、TSR3、ARMCX1、CRHR1、GLI1、LUC7L、PDE1A、SH2B2、TSSC1、ARMCX2、CRHR2、GLI2、LUC7L2、PDE1B、SH2B3、TSSC4、ARMCX3、CRIM1、GLI3、LUC7L3、PDE1C、SH2D1A、TSSK1B、ARMCX4、CRIP1、GLI4、LUM、PDE2A、SH2D1B、TSSK2、ARMCX5、CRIP2、GLIPR1、LURAP1、PDE3A、SH2D2A、TSSK3、ARMCX5-GPRASP2、CRIP3、GLIPR1L1、LURAP1L、PDE3B、SH2D3A、TSSK4、ARMCX6、CRIPAK、GLIPR1L2、LUZP1、PDE4A、SH2D3C、TSSK6、ARMS2、CRIPT、GLIPR2、LUZP2、PDE4B、SH2D4A、TST、ARNT、CRISP1、GLIS1、LUZP4、PDE4C、SH2D4B、TSTA3、ARNT2、CRISP2、GLIS2、LUZP6、PDE4D、SH2D5、TSTD1、ARNTL、CRISP3、GLIS3、LXN、PDE4DIP、SH2D6、TSTD2、ARNTL2、CRISPLD1、GLMN、LY6D、PDE5A、SH2D7、TSTD3、ARPC1A、CRISPLD2、GLO1、LY6E、PDE6A、SH3BGR、TTBK1、ARPC1B、CRK、GLOD4、LY6G5B、PDE6B、SH3BGRL、TTBK2、ARPC2、CRKL、GLOD5、LY6G5C、PDE6C、SH3BGRL2、TTC1、ARPC3、CRLF1、GLP1R、LY6G6C、PDE6D、SH3BGRL3、TTC12、ARPC4、CRLF2、GLP2R、LY6G6D、PDE6G、SH3BP1、TTC13、ARPC4-TTLL3、CRLF3、GLRA1、LY6G6F、PDE6H、SH3BP2、TTC14、ARPC5、CRLS1、GLRA2、LY6H、PDE7A、SH3BP4、TTC16、ARPC5L、CRMP1、GLRA3、LY6K、PDE7B、SH3BP5、TTC17、ARPP19、CRNKL1、GLRA4、LY75、PDE8A、SH3BP5L、TTC18、ARPP21、CRNN、GLRB、LY75-CD302、PDE8B、SH3D19、TTC19、ARR3、CROCC、GLRX、LY86、PDE9A、SH3D21、TTC21A、ARRB1、CROT、GLRX2、LY9、PDF、SH3GL1、TTC21B、ARRB2、CRP、GLRX3、LY96、PDGFA、SH3GL2、TTC22、ARRDC1、CRTAC1、GLRX5、LYAR、PDGFB、SH3GL3、TTC23、ARRDC2、CRTAM、GLS、LYG1、PDGFC、SH3GLB1、TTC23L、ARRDC3、CRTAP、GLS2、LYG2、PDGFD、SH3GLB2、TTC24、ARRDC4、CRTC1、GLT1D1、LYL1、PDGFRA、SH3KBP1、TTC25、ARRDC5、CRTC2、GLT6D1、LYN、PDGFRB、SH3PXD2A、TTC26、ARSA、CRTC3、GLT8D1、LYNX1、PDGFRL、SH3PXD2B、TTC27、ARSB、CRX、GLT8D2、LYPD1、PDHA1、SH3RF1、TTC28、ARSD、CRY1、GLTP、LYPD2、PDHA2、SH3RF2、TTC29、ARSE、CRY2、GLTPD1、LYPD3、PDHB、SH3RF3、TTC3、ARSF、CRYAA、GLTPD2、LYPD4、PDHX、SH3TC1、TTC30A、ARSG、CRYAB、GLTSCR1、LYPD5、PDIA2、SH3TC2、TTC30B、ARSH、CRYBA1、GLTSCR1L、LYPD6、PDIA3、SH3YL1、TTC31、ARSI、CRYBA2、GLTSCR2、LYPD6B、PDIA4、SHANK1、TTC32、ARSJ、CRYBA4、GLUD1、LYPD8、PDIA5、SHANK2、TTC33、ARSK、CRYBB1、GLUD2、LYPLA1、PDIA6、SHANK3、TTC34、ART1、CRYBB2、GLUL、LYPLA2、PDIK1L、SHARPIN、
TTC36、ART3、CRYBB3、GLYAT、LYPLAL1、PDILT、SHB、TTC37、ART4、CRYBG3、GLYATL1、LYRM1、PDK1、SHBG、TTC38、ART5、CRYGA、GLYATL2、LYRM2、PDK2、SHC1、TTC39A、ARTN、CRYGB、GLYATL3、LYRM4、PDK3、SHC2、TTC39B、ARV1、CRYGC、GLYCTK、LYRM5、PDK4、SHC3、TTC39C、ARVCF、CRYGD、GLYR1、LYRM7、PDLIM1、SHC4、TTC4、ARX、CRYGN、GM2A、LYRM9、PDLIM2、SHCBP1、TTC40、AS3MT、CRYGS、GMCL1、LYSMD1、PDLIM3、SHCBP1L、TTC5、ASAH1、CRYL1、GMDS、LYSMD2、PDLIM4、SHD、TTC6、ASAH2、CRYM、GMEB1、LYSMD3、PDLIM5、SHE、TTC7A、ASAH2B、CRYZ、GMEB2、LYSMD4、PDLIM7、SHF、TTC7B、ASAP1、CRYZL1、GMFB、LYST、PDP1、SHFM1、TTC8、ASAP2、CS、GMFG、LYVE1、PDP2、SHH、TTC9、ASAP3、CSAD、GMIP、LYZ、PDPK1、SHISA2、TTC9B、ASB1、CSAG1、GML、LYZL1、PDPN、SHISA3、TTC9C、ASB10、CSAG2、GMNC、LYZL2、PDPR、SHISA4、TTF1、ASB11、CSAG3、GMNN、LYZL4、PDRG1、SHISA5、TTF2、ASB12、CSDC2、GMPPA、LYZL6、PDS5A、SHISA6、TTI1、ASB13、CSDE1、GMPPB、LZIC、PDS5B、SHISA7、TTI2、ASB14、CSE1L、GMPR、LZTFL1、PDSS1、SHISA8、TTK、ASB15、CSF1、GMPR2、LZTR1、PDSS2、SHISA9、TTL、ASB16、CSF1R、GMPS、LZTS1、PDX1、SHKBP1、TTLL1、ASB17、CSF2、GNA11、LZTS2、PDXDC1、SHMT1、TTLL10、ASB18、CSF2RA、GNA12、LZTS3、PDXK、SHMT2、TTLL11、ASB2、CSF2RB、GNA13、M1AP、PDXP、SHOC2、TTLL12、ASB3、CSF3、GNA14、M6PR、PDYN、SHOX、TTLL13、ASB4、CSF3R、GNA15、MAATS1、PDZD11、SHOX2、TTLL2、ASB5、CSGALNACT1、GNAI1、MAB21L1、PDZD2、SHPK、TTLL3、ASB6、CSGALNACT2、GNAI2、MAB21L2、PDZD3、SHPRH、TTLL4、ASB7、CSH1、GNAI3、MAB21L3、PDZD4、SHQ1、TTLL5、ASB8、CSH2、GNAL、MACC1、PDZD7、SHROOM1、TTLL6、ASB9、CSHL1、GNAO1、MACF1、PDZD8、SHROOM2、TTLL7、ASCC1、CSK、GNAQ、MACROD1、PDZD9、SHROOM3、TTLL8、ASCC2、CSMD1、GNAS、MACROD2、PDZK1、SHROOM4、TTLL9、ASCC3、CSMD2、GNAT1、MAD1L1、PDZK1IP1、SI、TTN、ASCL1、CSMD3、GNAT2、MAD2L1、PDZRN3、SIAE、TTPA、ASCL2、CSN1S1、GNAT3、MAD2L1BP、PDZRN4、SIAH1、TTPAL、ASCL3、CSN2、GNAZ、MAD2L2、PEA15、SIAH2、TTR、ASCL4、CSN3、GNB1、MADCAM1、PEAK1、SIAH3、TTYH1、ASCL5、CSNK1A1、GNB1L、MADD、PEAR1、SIDT1、TTYH2、ASF1A、CSNK1A1L、GNB2、MAEA、PEBP1、SIDT2、TTYH3、ASF1B、CSNK1D、GNB2L1、MAEL、PEBP4、SIGIRR、TUB、ASGR1、CSNK1E、GNB3、MAF、PECAM1、SIGLEC1、TUBA1A、ASGR2、CSNK1G1、GNB4、MAF1、PECR、SIGLEC10、TUBA1B、ASH1L、CSNK1G2、GNB5、MAFA、PEF1、SIGLEC11、TUBA1C、ASH2L、CSNK1G3、GNE、MAFB、PEG10、SIGLEC12、TUBA3C、ASIC1、CSNK2A1、GNG10、MAFF、PEG3、SIGLEC14、TUBA3D、ASIC2、CSNK2A2、GNG11、MAFG、PELI1、SIGLEC15、TUBA3E、ASIC3、CSNK2A3、GNG12、MAFK、PELI2、SIGLEC5、TUBA4A、ASIC4、CSNK2B、GNG13、MAG、PELI3、SIGLEC6、TUBA8、ASIC5、CSPG4、GNG2、MAGEA1、PELO、SIGLEC7、TUBAL3、ASIP、CSPG5、GNG3、MAGEA10、PELP1、SIGLEC8、TUBB、ASL、CSPP1、GNG4、MAGEA10-MAGEA5、PEMT、SIGLEC9、TUBB1、ASMT、CSRNP1、GNG5、MAGEA11、PENK、SIGLECL1、TUBB2A、ASMTL、CSRNP2、GNG7、MAGEA12、PEPD、SIGMAR1、TUBB2B、ASNA1、CSRNP3、GNG8、MAGEA3、PER1、SIK1、TUBB3、ASNS、CSRP1、GNGT1、MAGEA4、PER2、SIK2、TUBB4A、ASNSD1、CSRP2、GNGT2、MAGEA5、PER3、SIK3、TUBB4B、ASPA、CSRP2BP、GNL1、MAGEA6、PERM1、SIKE1、TUBB6、ASPDH、CSRP3、GNL2、MAGEA8、PERP、SIL1、TUBB8、
	ASPG、CST1、GNL3、MAGEB1、PES1、SIM1、TUBD1、ASPH、CST11、GNL3L、MAGEB10、PET100、SIM2、TUBE1、ASPHD1、CST2、GNLY、MAGEB16、PET112、SIMC1、TUBG1、ASPHD2、CST3、GNMT、MAGEB17、PET117、SIN3A、TUBG2、ASPM、CST4、GNPAT、MAGEB18、PEX1、SIN3B、TUBGCP2、ASPN、CST5、GNPDA1、MAGEB2、PEX10、SIPA1、TUBGCP3、ASPRV1、CST6、GNPDA2、MAGEB3、PEX11A、SIPA1L1、TUBGCP4、ASPSCR1、CST7、GNPNAT1、MAGEB4、PEX11B、SIPA1L2、TUBGCP5、ASRGL1、CST8、GNPTAB、MAGEB5、PEX11G、SIPA1L3、TUBGCP6、ASS1、CST9、GNPTG、MAGEB6、PEX12、SIRPA、TUFM、ASTE1、CST9L、GNRH1、MAGEC1、PEX13、SIRPB1、TUFT1、ASTL、CSTA、GNRH2、MAGEC2、PEX14、SIRPB2、TULP1、ASTN1、CSTB、GNRHR、MAGEC3、PEX16、SIRPD、TULP2、ASTN2、CSTF1、GNS、MAGED1、PEX19、SIRPG、TULP3、ASUN、CSTF2、GOLGA1、MAGED2、PEX2、SIRT1、TULP4、ASXL1、CSTF2T、GOLGA2、MAGEE1、PEX26、SIRT2、TUSC1、ASXL2、CSTF3、GOLGA3、MAGEE2、PEX3、SIRT3、TUSC2、ASXL3、CSTL1、GOLGA4、MAGEF1、PEX5、SIRT4、TUSC3、ASZ1、CT45A1、GOLGA5、MAGEH1、PEX5L、SIRT5、TUSC5、ATAD1、CT45A2、GOLGA6A、MAGEL2、PEX6、SIRT6、TUT1、ATAD2、CT45A3、GOLGA6B、MAGI1、PEX7、SIRT7、TVP23A、ATAD2B、CT45A4、GOLGA6C、MAGI2、PF4、SIT1、TVP23B、ATAD3A、CT45A5、GOLGA6D、MAGI3、PF4V1、SIVA1、TVP23C、ATAD3B、CT45A6、GOLGA6L1、MAGIX、PFAS、SIX1、TVP23C-CDRT4、ATAD3C、CT47A1、GOLGA6L10、MAGOH、PFDN1、SIX2、TWF1、ATAD5、CT47A10、GOLGA6L2、MAGOHB、PFDN2、SIX3、TWF2、ATAT1、CT47A11、GOLGA6L3、MAGT1、PFDN4、SIX4、TWIST1、ATCAY、CT47A12、GOLGA6L4、MAK、PFDN5、SIX5、TWIST2、ATE1、CT47A2、GOLGA6L6、MAK16、PFDN6、SIX6、TWISTNB、ATF1、CT47A3、GOLGA6L9、MAL、PFKFB1、SKA1、TWSG1、ATF2、CT47A4、GOLGA7、MAL2、PFKFB2、SKA2、TXK、ATF3、CT47A5、GOLGA7B、MALL、PFKFB3、SKA3、TXLNA、ATF4、CT47A6、GOLGA8A、MALSU1、PFKFB4、SKAP1、TXLNB、ATF5、CT47A7、GOLGA8B、MALT1、PFKL、SKAP2、TXLNG、ATF6、CT47A8、GOLGA8H、MAMDC2、PFKM、SKI、TXN、ATF6B、CT47A9、GOLGA8J、MAMDC4、PFKP、SKIDA1、TXN2、ATF7、CT47B1、GOLGA8K、MAML1、PFN1、SKIL、TXNDC11、ATF7IP、CT62、GOLGA8M、MAML2、PFN2、SKIV2L、TXNDC12、ATF7IP2、CTAG1A、GOLGA8O、MAML3、PFN3、SKIV2L2、TXNDC15、ATG10、CTAG1B、GOLGA8R、MAMLD1、PFN4、SKOR1、TXNDC16、ATG12、CTAG2、GOLGB1、MAMSTR、PGA3、SKOR2、TXNDC17、ATG13、CTAGE1、GOLIM4、MAN1A1、PGA4、SKP1、TXNDC2、ATG14、CTAGE15、GOLM1、MAN1A2、PGA5、SKP2、TXNDC5、ATG16L1、CTAGE4、GOLPH3、MAN1B1、PGAM1、SLA、TXNDC8、ATG16L2、CTAGE5、GOLPH3L、MAN1C1、PGAM2、SLA2、TXNDC9、ATG2A、CTAGE6、GOLT1A、MAN2A1、PGAM4、SLAIN1、TXNIP、ATG2B、CTAGE8、GOLT1B、MAN2A2、PGAM5、SLAIN2、TXNL1、ATG3、CTAGE9、GON4L、MAN2B1、PGAP1、SLAMF1、TXNL4A、ATG4A、CTBP1、GOPC、MAN2B2、PGAP2、SLAMF6、TXNL4B、ATG4B、CTBP2、GORAB、MAN2C1、PGAP3、SLAMF7、TXNRD1、ATG4C、CTBS、GORASP1、MANBA、PGBD1、SLAMF8、TXNRD2、ATG4D、CTC1、GORASP2、MANBAL、PGBD2、SLAMF9、TXNRD3、ATG5、CTCF、GOSR1、MANEA、PGBD3、SLBP、TXNRD3NB、ATG7、CTCFL、GOSR2、MANEAL、PGBD4、SLC10A1、TYK2、ATG9A、CTDNEP1、GOT1、MANF、PGBD5、SLC10A2、TYMP、ATG9B、CTDP1、GOT1L1、MANSC1、PGC、SLC10A3、TYMS、ATHL1、CTDSP1、GOT2、MANSC4、PGD、SLC10A4、
TYR、ATIC、CTDSP2、GP1BA、MAOA、PGF、SLC10A5、TYRO3、ATL1、CTDSPL、GP1BB、MAOB、PGGT1B、SLC10A6、TYROBP、ATL2、CTDSPL2、GP2、MAP10、PGK1、SLC10A7、TYRP1、ATL3、CTF1、GP5、MAP1A、PGK2、SLC11A1、TYSND1、ATM、CTGF、GP6、MAP1B、PGLS、SLC11A2、TYW1、ATMIN、CTH、GP9、MAP1LC3A、PGLYRP1、SLC12A1、TYW1B、ATN1、CTHRC1、GPA33、MAP1LC3B、PGLYRP2、SLC12A2、TYW3、ATOH1、CTIF、GPAA1、MAP1LC3B2、PGLYRP3、SLC12A3、TYW5、ATOH7、CTLA4、GPALPP1、MAP1LC3C、PGLYRP4、SLC12A4、U2AF1、ATOH8、CTNNA1、GPAM、MAP1S、PGM1、SLC12A5、U2AF1L4、ATOX1、CTNNA2、GPANK1、MAP2、PGM2、SLC12A6、U2AF2、ATP10A、CTNNA3、GPAT2、MAP2K1、PGM2L1、SLC12A7、U2SURP、ATP10B、CTNNAL1、GPATCH1、MAP2K2、PGM3、SLC12A8、UACA、ATP10D、CTNNB1、GPATCH11、MAP2K3、PGM5、SLC12A9、UAP1、ATP11A、CTNNBIP1、GPATCH2、MAP2K4、PGP、SLC13A1、UAP1L1、ATP11B、CTNNBL1、GPATCH2L、MAP2K5、PGPEP1、SLC13A2、UBA1、ATP11C、CTNND1、GPATCH3、MAP2K6、PGPEP1L、SLC13A3、UBA2、ATP12A、CTNND2、GPATCH4、MAP2K7、PGR、SLC13A4、UBA3、ATP13A1、CTNS、GPATCH8、MAP3K1、PGRMC1、SLC13A5、UBA5、ATP13A2、CTPS1、GPBAR1、MAP3K10、PGRMC2、SLC14A1、UBA52、ATP13A3、CTPS2、GPBP1、MAP3K11、PGS1、SLC14A2、UBA6、ATP13A4、CTR9、GPBP1L1、MAP3K12、PHACTR1、SLC15A1、UBA7、ATP13A5、CTRB1、GPC1、MAP3K13、PHACTR2、SLC15A2、UBAC1、ATP1A1、CTRB2、GPC2、MAP3K14、PHACTR3、SLC15A3、UBAC2、ATP1A2、CTRC、GPC3、MAP3K15、PHACTR4、SLC15A4、UBALD1、ATP1A3、CTRL、GPC4、MAP3K19、PHAX、SLC15A5、UBALD2、ATP1A4、CTSA、GPC5、MAP3K2、PHB、SLC16A1、UBAP1、ATP1B1、CTSB、GPC6、MAP3K3、PHB2、SLC16A10、UBAP1L、ATP1B2、CTSC、GPCPD1、MAP3K4、PHC1、SLC16A11、UBAP2、ATP1B3、CTSD、GPD1、MAP3K5、PHC2、SLC16A12、UBAP2L、ATP1B4、CTSE、GPD1L、MAP3K6、PHC3、SLC16A13、UBASH3A、ATP2A1、CTSF、GPD2、MAP3K7、PHEX、SLC16A14、UBASH3B、ATP2A2、CTSG、GPER1、MAP3K7CL、PHF1、SLC16A2、UBB、ATP2A3、CTSH、GPHA2、MAP3K8、PHF10、SLC16A3、UBC、ATP2B1、CTSK、GPHB5、MAP3K9、PHF11、SLC16A4、UBD、ATP2B2、CTSL、GPHN、MAP4、PHF12、SLC16A5、UBE2A、ATP2B3、CTSO、GPI、MAP4K1、PHF13、SLC16A6、UBE2B、ATP2B4、CTSS、GPIHBP1、MAP4K2、PHF14、SLC16A7、UBE2C、ATP2C1、CTSV、GPKOW、MAP4K3、PHF19、SLC16A8、UBE2D1、ATP2C2、CTSW、GPLD1、MAP4K4、PHF2、SLC16A9、UBE2D2、ATP4A、CTSZ、GPM6A、MAP4K5、PHF20、SLC17A1、UBE2D3、ATP4B、CTTN、GPM6B、MAP6、PHF20L1、SLC17A2、UBE2D4、ATP5A1、CTTNBP2、GPN1、MAP6D1、PHF21A、SLC17A3、UBE2E1、ATP5B、CTTNBP2NL、GPN2、MAP7、PHF21B、SLC17A4、UBE2E2、ATP5C1、CTU1、GPN3、MAP7D1、PHF23、SLC17A5、UBE2E2-AS1、ATP5D、CTU2、GPNMB、MAP7D2、PHF3、SLC17A6、UBE2E3、ATP5E、CTXN1、GPR1、MAP7D3、PHF5A、SLC17A7、UBE2F、ATP5F1、CTXN2、GPR101、MAP9、PHF6、SLC17A8、UBE2G1、ATP5G1、CTXN3、GPR107、MAPK1、PHF7、SLC17A9、UBE2G2、ATP5G2、CUBN、GPR108、MAPK10、PHF8、SLC18A1、UBE2H、ATP5G3、CUEDC1、GPR110、MAPK11、PHGDH、SLC18A2、UBE2I、ATP5H、CUEDC2、GPR111、MAPK12、PHGR1、SLC18A3、UBE2J1、ATP5I、CUL1、GPR112、MAPK13、PHIP、SLC18B1、UBE2J2、ATP5J、CUL2、GPR113、MAPK14、PHKA1、SLC19A1、UBE2K、ATP5J2、CUL3、GPR114、MAPK15、PHKA2、SLC19A2、UBE2L3、
	ATP5J2-PTCD1、CUL4A、GPR115、MAPK1IP1L、PHKB、SLC19A3、UBE2L6、ATP5L、CUL4B、GPR116、MAPK3、PHKG1、SLC1A1、UBE2M、ATP5L2、CUL5、GPR119、MAPK4、PHKG2、SLC1A2、UBE2N、ATP5O、CUL7、GPR12、MAPK6、PHLDA1、SLC1A3、UBE2NL、ATP5S、CUL9、GPR123、MAPK7、PHLDA2、SLC1A4、UBE2O、ATP5SL、CUTA、GPR124、MAPK8、PHLDA3、SLC1A5、UBE2Q1、ATP6AP1、CUTC、GPR125、MAPK8IP1、PHLDB1、SLC1A6、UBE2Q2、ATP6AP1L、CUX1、GPR126、MAPK8IP2、PHLDB2、SLC1A7、UBE2QL1、ATP6AP2、CUX2、GPR128、MAPK8IP3、PHLDB3、SLC20A1、UBE2R2、ATP6V0A1、CUZD1、GPR132、MAPK9、PHLPP1、SLC20A2、UBE2S、ATP6V0A2、CWC15、GPR133、MAPKAP1、PHLPP2、SLC22A1、UBE2T、ATP6V0A4、CWC22、GPR135、MAPKAPK2、PHOSPHO1、SLC22A10、UBE2U、ATP6V0B、CWC25、GPR137、MAPKAPK3、PHOSPHO2、SLC22A11、UBE2V1、ATP6V0C、CWC27、GPR137B、MAPKAPK5、PHOSPHO2-KLHL23、SLC22A12、UBE2V2、ATP6V0D1、CWF19L1、GPR137C、MAPKBP1、PHOX2A、SLC22A13、UBE2W、ATP6V0D2、CWF19L2、GPR139、MAPRE1、PHOX2B、SLC22A14、UBE2Z、ATP6V0E1、CWH43、GPR142、MAPRE2、PHPT1、SLC22A15、UBE3A、ATP6V0E2、CX3CL1、GPR143、MAPRE3、PHRF1、SLC22A16、UBE3B、ATP6V1A、CX3CR1、GPR148、MAPT、PHTF1、SLC22A17、UBE3C、ATP6V1B1、CXADR、GPR149、1-Mar、PHTF2、SLC22A18、UBE3D、ATP6V1B2、CXCL1、GPR15、10-Mar、PHYH、SLC22A18AS、UBE4A、ATP6V1C1、CXCL10、GPR150、11- Mar、PHYHD1、SLC22A2、UBE4B、ATP6V1C2、CXCL11、GPR151、2-Mar、PHYHIP、SLC22A20、UBFD1、ATP6V1D、CXCL12、GPR152、3-Mar、PHYHIPL、SLC22A23、UBIAD1、ATP6V1E1、CXCL13、GPR153、4- Mar、PHYKPL、SLC22A24、UBL3、ATP6V1E2、CXCL14、GPR155、5-Mar、PI15、SLC22A25、UBL4A、ATP6V1F、CXCL16、GPR156、6-Mar、PI16、SLC22A3、UBL4B、ATP6V1G1、CXCL17、GPR157、7-Mar、PI3、SLC22A31、UBL5、ATP6V1G2、CXCL2、GPR158、8-Mar、PI4K2A、SLC22A4、UBL7、ATP6V1G3、CXCL3、GPR160、9-Mar、PI4K2B、SLC22A5、UBLCP1、ATP6V1H、CXCL5、GPR161、MARCKS、PI4KA、SLC22A6、UBN1、ATP7A、CXCL6、GPR162、MARCKSL1、PI4KB、SLC22A7、UBN2、ATP7B、CXCL9、GPR17、MARCO、PIANP、SLC22A8、UBOX5、ATP8A1、CXCR1、GPR171、MARK1、PIAS1、SLC22A9、UBP1、ATP8A2、CXCR2、GPR173、MARK2、PIAS2、SLC23A1、UBQLN1、ATP8B1、CXCR3、GPR174、MARK3、PIAS3、SLC23A2、UBQLN2、ATP8B2、CXCR4、GPR176、MARK4、PIAS4、SLC23A3、UBQLN3、ATP8B3、CXCR5、GPR179、MARS、PIBF1、SLC24A1、UBQLN4、ATP8B4、CXCR6、GPR18、MARS2、PICALM、SLC24A2、UBQLNL、ATP9A、CXorf21、GPR180、MARVELD1、PICK1、SLC24A3、UBR1、ATP9B、CXorf22、GPR182、MARVELD2、PID1、SLC24A4、UBR2、ATPAF1、CXorf23、GPR183、MARVELD3、PIDD、SLC24A5、UBR3、ATPAF2、CXorf27、GPR19、MAS1、PIEZO1、SLC25A1、UBR4、ATPIF1、CXorf30、GPR20、MAS1L、PIEZO2、SLC25A10、UBR5、ATR、CXorf36、GPR21、MASP1、PIF1、SLC25A11、UBR7、ATRAID、CXorf38、GPR22、MASP2、PIFO、SLC25A12、UBTD1、ATRIP、CXorf40A、GPR25、MAST1、PIGA、SLC25A13、UBTD2、ATRN、CXorf40B、GPR26、MAST2、PIGB、SLC25A14、UBTF、ATRNL1、CXorf48、GPR27、MAST3、PIGC、SLC25A15、UBTFL1、ATRX、CXorf49、GPR3、MAST4、PIGF、SLC25A16、UBXN1、ATXN1、CXorf49B、GPR31、MASTL、PIGG、SLC25A17、UBXN10、ATXN10、CXorf51A、GPR32、MAT1A、PIGH、SLC25A18、UBXN11、ATXN1L、
CXorf51B、GPR33、MAT2A、PIGK、SLC25A19、UBXN2A、ATXN2、CXorf56、GPR34、MAT2B、PIGL、SLC25A2、UBXN2B、ATXN2L、CXorf57、GPR35、MATK、PIGM、SLC25A20、UBXN4、ATXN3、CXorf58、GPR37、MATN1、PIGN、SLC25A21、UBXN6、ATXN3L、CXorf61、GPR37L1、MATN2、PIGO、SLC25A22、UBXN7、ATXN7、CXorf64、GPR39、MATN3、PIGP、SLC25A23、UBXN8、ATXN7L1、CXorf65、GPR4、MATN4、PIGQ、SLC25A24、UCHL1、ATXN7L2、CXorf66、GPR45、MATR3、PIGR、SLC25A25、UCHL3、ATXN7L3、CXXC1、GPR50、MAU2、PIGS、SLC25A26、UCHL5、ATXN7L3B、CXXC11、GPR52、MAVS、PIGT、SLC25A27、UCK1、AUH、CXXC4、GPR55、MAX、PIGU、SLC25A28、UCK2、AUNIP、CXXC5、GPR56、MAZ、PIGV、SLC25A29、UCKL1、AUP1、CYB561、GPR6、MB、PIGW、SLC25A3、UCMA、AURKA、CYB561A3、GPR61、MB21D1、PIGX、SLC25A30、UCN、AURKAIP1、CYB561D1、GPR62、MB21D2、PIGY、SLC25A31、UCN2、AURKB、CYB561D2、GPR63、MBD1、PIGZ、SLC25A32、UCN3、AURKC、CYB5A、GPR64、MBD2、PIH1D1、SLC25A33、UCP1、AUTS2、CYB5B、GPR65、MBD3、PIH1D2、SLC25A34、UCP2、AVEN、CYB5D1、GPR68、MBD3L1、PIH1D3、SLC25A35、UCP3、AVIL、CYB5D2、GPR75、MBD4、PIK3AP1、SLC25A36、UEVLD、AVL9、CYB5R1、GPR75-ASB3、MBD5、PIK3C2A、SLC25A37、UFC1、AVP、CYB5R2、GPR78、MBD6、PIK3C2B、SLC25A38、UFD1L、AVPI1、CYB5R3、GPR82、MBIP、PIK3C2G、SLC25A39、UFL1、AVPR1A、CYB5R4、GPR83、MBL2、PIK3C3、SLC25A4、UFM1、AVPR1B、CYB5RL、GPR84、MBLAC1、PIK3CA、SLC25A40、UFSP1、AVPR2、CYBA、GPR85、MBLAC2、PIK3CB、SLC25A41、UFSP2、AWAT1、CYBB、GPR87、MBNL1、PIK3CD、SLC25A42、UGCG、AWAT2、CYBRD1、GPR88、MBNL2、PIK3CG、SLC25A43、UGDH、AXDND1、CYC1、GPR89A、MBNL3、PIK3IP1、SLC25A44、UGGT1、AXIN1、CYCS、GPR89B、MBOAT1、PIK3R1、SLC25A45、UGGT2、AXIN2、CYFIP1、GPR89C、MBOAT2、PIK3R2、SLC25A46、UGP2、AXL、CYFIP2、GPR97、MBOAT4、PIK3R3、SLC25A47、UGT1A1、AZGP1、CYGB、GPR98、MBOAT7、PIK3R4、SLC25A48、UGT1A10、AZI1、CYHR1、GPRASP1、MBP、PIK3R5、SLC25A5、UGT1A3、AZI2、CYLC1、GPRASP2、MBTD1、PIK3R6、SLC25A51、UGT1A4、AZIN1、CYLC2、GPRC5A、MBTPS1、PIKFYVE、SLC25A52、UGT1A5、AZU1、CYLD、GPRC5B、MBTPS2、PILRA、SLC25A53、UGT1A6、B2M、CYorf17、GPRC5C、MC1R、PILRB、SLC25A6、UGT1A7、B3GALNT1、CYP11A1、GPRC5D、MC2R、PIM1、SLC26A1、UGT1A8、B3GALNT2、CYP11B1、GPRC6A、MC3R、PIM2、SLC26A10、UGT1A9、B3GALT1、CYP11B2、GPRIN1、MC4R、PIM3、SLC26A11、UGT2A1、B3GALT2、CYP17A1、GPRIN2、MC5R、PIN1、SLC26A2、UGT2A2、B3GALT4、CYP19A1、GPRIN3、MCAM、PIN4、SLC26A3、UGT2A3、B3GALT5、CYP1A1、GPS1、MCAT、PINK1、SLC26A4、UGT2B10、B3GALT6、CYP1A2、GPS2、MCC、PINLYP、SLC26A5、UGT2B11、B3GALTL、CYP1B1、GPSM1、MCCC1、PINX1、SLC26A6、UGT2B15、B3GAT1、CYP20A1、GPSM2、MCCC2、PIP、SLC26A7、UGT2B17、B3GAT2、CYP21A2、GPSM3、MCCD1、PIP4K2A、SLC26A8、UGT2B28、B3GAT3、CYP24A1、GPT、MCEE、PIP4K2B、SLC26A9、UGT2B4、B3GNT1、CYP26A1、GPT2、MCF2、PIP4K2C、SLC27A1、UGT2B7、B3GNT2、CYP26B1、GPX1、MCF2L、PIP5K1A、SLC27A2、UGT3A1、B3GNT3、CYP26C1、GPX2、MCF2L2、PIP5K1B、SLC27A3、UGT3A2、B3GNT4、CYP27A1、GPX3、MCFD2、PIP5K1C、SLC27A4、UGT8、B3GNT5、CYP27B1、GPX4、MCHR1、PIP5KL1、SLC27A5、UHMK1、B3GNT6、
	CYP27C1、GPX5、MCHR2、PIPOX、SLC27A6、UHRF1、B3GNT7、CYP2A13、GPX6、MCIDAS、PIR、SLC28A1、UHRF1BP1、B3GNT8、CYP2A6、GPX7、MCL1、PIRT、SLC28A2、UHRF1BP1L、B3GNT9、CYP2A7、GPX8、MCM10、PISD、SLC28A3、UHRF2、B3GNTL1、CYP2B6、GRAMD1A、MCM2、PITHD1、SLC29A1、UIMC1、B4GALNT1、CYP2C18、GRAMD1B、MCM3、PITPNA、SLC29A2、ULBP1、B4GALNT2、CYP2C19、GRAMD1C、MCM3AP、PITPNB、SLC29A3、ULBP2、B4GALNT3、CYP2C8、GRAMD2、MCM4、PITPNC1、SLC29A4、ULBP3、B4GALNT4、CYP2C9、GRAMD3、MCM5、PITPNM1、SLC2A1、ULK1、B4GALT1、CYP2D6、GRAMD4、MCM6、PITPNM2、SLC2A10、ULK2、B4GALT2、CYP2E1、GRAP、MCM7、PITPNM3、SLC2A11、ULK3、B4GALT3、CYP2F1、GRAP2、MCM8、PITRM1、SLC2A12、ULK4、B4GALT4、CYP2J2、GRAPL、MCM9、PITX1、SLC2A13、UMOD、B4GALT5、CYP2R1、GRASP、MCMBP、PITX2、SLC2A14、UMODL1、B4GALT6、CYP2S1、GRB10、MCMDC2、PITX3、SLC2A2、UMPS、B4GALT7、CYP2U1、GRB14、MCOLN1、PIWIL1、SLC2A3、UNC119、B9D1、CYP2W1、GRB2、MCOLN2、PIWIL2、SLC2A4、UNC119B、B9D2、CYP39A1、GRB7、MCOLN3、PIWIL3、SLC2A4RG、UNC13A、BAALC、CYP3A4、GREB1、MCPH1、PIWIL4、SLC2A5、UNC13B、BAAT、CYP3A43、GREM1、MCRS1、PJA1、SLC2A6、UNC13C、BABAM1、CYP3A5、GREM2、MCTP1、PJA2、SLC2A7、UNC13D、BACE1、CYP3A7、GRHL1、MCTP2、PKD1、SLC2A8、UNC45A、BACE2、CYP3A7- CYP3AP1、GRHL2、MCTS1、PKD1L1、SLC2A9、UNC45B、BACH1、CYP46A1、GRHL3、MCU、PKD1L2、SLC30A1、UNC50、BACH2、CYP4A11、GRHPR、MCUR1、PKD1L3、SLC30A10、UNC5A、BAD、CYP4A22、GRIA1、MDC1、PKD2、SLC30A2、UNC5B、BAG1、CYP4B1、GRIA2、MDFI、PKD2L1、SLC30A3、UNC5C、BAG2、CYP4F11、GRIA3、MDFIC、PKD2L2、SLC30A4、UNC5CL、BAG3、CYP4F12、GRIA4、MDGA1、PKDCC、SLC30A5、UNC5D、BAG4、CYP4F2、GRID1、MDGA2、PKDREJ、SLC30A6、UNC79、BAG5、CYP4F22、GRID2、MDH1、PKHD1、SLC30A7、UNC80、BAG6、CYP4F3、GRID2IP、MDH1B、PKHD1L1、SLC30A8、UNC93A、BAGE、CYP4F8、GRIFIN、MDH2、PKIA、SLC30A9、UNC93B1、BAGE2、CYP4V2、GRIK1、MDK、PKIB、SLC31A1、UNCX、BAGE3、CYP4X1、GRIK2、MDM1、PKIG、SLC31A2、UNG、BAHCC1、CYP4Z1、GRIK3、MDM2、PKLR、SLC32A1、UNK、BAHD1、CYP51A1、GRIK4、MDM4、PKM、SLC33A1、UNKL、BAI1、CYP7A1、GRIK5、MDN1、PKMYT1、SLC34A1、UPB1、BAI2、CYP7B1、GRIN1、MDP1、PKN1、SLC34A2、UPF1、BAI3、CYP8B1、GRIN2A、ME1、PKN2、SLC34A3、UPF2、BAIAP2、CYR61、GRIN2B、ME2、PKN3、SLC35A1、UPF3A、BAIAP2L1、CYS1、GRIN2C、ME3、PKNOX1、SLC35A2、UPF3B、BAIAP2L2、CYSLTR1、GRIN2D、MEA1、PKNOX2、SLC35A3、UPK1A、BAIAP3、CYSLTR2、GRIN3A、MEAF6、PKP1、SLC35A4、UPK1B、BAK1、CYSTM1、GRIN3B、MECOM、PKP2、SLC35A5、UPK2、BAMBI、CYTH1、GRINA、MECP2、PKP3、SLC35B1、UPK3A、BANF1、CYTH2、GRIP1、MECR、PKP4、SLC35B2、UPK3B、BANF2、CYTH3、GRIP2、MED1、PLA1A、SLC35B3、UPK3BL、BANK1、CYTH4、GRIPAP1、MED10、PLA2G10、SLC35B4、UPP1、BANP、CYTIP、GRK1、MED11、PLA2G12A、SLC35C1、UPP2、BAP1、CYTL1、GRK4、MED12、PLA2G12B、SLC35C2、UPRT、BARD1、CYYR1、GRK5、MED12L、PLA2G15、SLC35D1、UQCC1、BARHL1、D2HGDH、GRK6、MED13、PLA2G16、SLC35D2、UQCC2、BARHL2、DAAM1、GRK7、MED13L、PLA2G1B、SLC35D3、UQCR10、BARX1、DAAM2、GRM1、MED14、PLA2G2A、SLC35E1、UQCR11、BARX2、DAB1、GRM2、MED15、PLA2G2C、SLC35E2、UQCRB、BASP1、
DAB2、GRM3、MED16、PLA2G2D、SLC35E2B、UQCRC1、BATF、DAB2IP、GRM4、MED17、PLA2G2E、SLC35E3、UQCRC2、BATF2、DACH1、GRM5、MED18、PLA2G2F、SLC35E4、UQCRFS1、BATF3、DACH2、GRM6、MED19、PLA2G3、SLC35F1、UQCRH、BAX、DACT1、GRM7、MED20、PLA2G4A、SLC35F2、UQCRHL、BAZ1A、DACT2、GRM8、MED21、PLA2G4B、SLC35F3、UQCRQ、BAZ1B、DACT3、GRN、MED22、PLA2G4C、SLC35F4、URAD、BAZ2A、DAD1、GRP、MED23、PLA2G4D、SLC35F5、URB1、BAZ2B、DAG1、GRPEL1、MED24、PLA2G4E、SLC35F6、URB2、BBC3、DAGLA、GRPEL2、MED25、PLA2G4F、SLC35G1、URGCP、BBIP1、DAGLB、GRPR、MED26、PLA2G5、SLC35G2、URGCP-MRPS24、BBOX1、DAK、GRSF1、MED27、PLA2G6、SLC35G3、URI1、BBS1、DALRD3、GRTP1、MED28、PLA2G7、SLC35G4、URM1、BBS10、DAND5、GRWD1、MED29、PLA2R1、SLC35G5、UROC1、BBS12、DAO、GRXCR1、MED30、PLAA、SLC35G6、UROD、BBS2、DAOA、GRXCR2、MED31、PLAC1、SLC36A1、UROS、BBS4、DAP、GSAP、MED4、PLAC4、SLC36A2、USB1、BBS5、DAP3、GSC、MED6、PLAC8、SLC36A3、USE1、BBS7、DAPK1、GSC2、MED7、PLAC8L1、SLC36A4、USF1、BBS9、DAPK2、GSDMA、MED8、PLAC9、SLC37A1、USF2、BBX、DAPK3、GSDMB、MED9、PLAG1、SLC37A2、USH1C、BCAM、DAPL1、GSDMC、MEDAG、PLAGL1、SLC37A3、USH1G、BCAN、DAPP1、GSDMD、MEF2A、PLAGL2、SLC37A4、USH2A、BCAP29、DARS、GSE1、MEF2B、PLAT、SLC38A1、USHBP1、BCAP31、DARS2、GSG1、MEF2BNB、PLAU、SLC38A10、USMG5、BCAR1、DAW1、GSG1L、MEF2BNB-MEF2B、PLAUR、SLC38A11、USO1、BCAR3、DAXX、GSG2、MEF2C、PLB1、SLC38A2、USP1、BCAS1、DAZ1、GSK3A、MEF2D、PLBD1、SLC38A3、USP10、BCAS2、DAZ2、GSK3B、MEFV、PLBD2、SLC38A4、USP11、BCAS3、DAZ3、GSKIP、MEGF10、PLCB1、SLC38A5、USP12、BCAS4、DAZ4、GSN、MEGF11、PLCB2、SLC38A6、USP13、BCAT1、DAZAP1、GSPT1、MEGF6、PLCB3、SLC38A7、USP14、BCAT2、DAZAP2、GSPT2、MEGF8、PLCB4、SLC38A8、USP15、BCCIP、DAZL、GSR、MEGF9、PLCD1、SLC38A9、USP16、BCDIN3D、DBF4、GSS、MEI1、PLCD3、SLC39A1、USP17L24、BCHE、DBF4B、GSTA1、MEI4、PLCD4、SLC39A10、USP17L25、BCKDHA、DBH、GSTA2、MEIG1、PLCE1、SLC39A11、USP17L26、BCKDHB、DBI、GSTA3、MEIOB、PLCG1、SLC39A12、USP17L28、BCKDK、DBN1、GSTA4、MEIS1、PLCG2、SLC39A13、USP17L29、BCL10、DBNDD1、GSTA5、MEIS2、PLCH1、SLC39A14、USP18、BCL11A、DBNDD2、GSTCD、MEIS3、PLCH2、SLC39A2、USP19、BCL11B、DBNL、GSTK1、MELK、PLCL1、SLC39A3、USP2、BCL2、DBP、GSTM1、MEMO1、PLCL2、SLC39A4、USP20、BCL2A1、DBR1、GSTM2、MEN1、PLCXD1、SLC39A5、USP21、BCL2L1、DBT、GSTM3、MEOX1、PLCXD2、SLC39A6、USP22、BCL2L10、DBX1、GSTM4、MEOX2、PLCXD3、SLC39A7、USP24、BCL2L11、DBX2、GSTM5、MEP1A、PLCZ1、SLC39A8、USP25、BCL2L12、DCAF10、GSTO1、MEP1B、PLD1、SLC39A9、USP26、BCL2L13、DCAF11、GSTO2、MEPCE、PLD2、SLC3A1、USP27X、BCL2L14、DCAF12、GSTP1、MEPE、PLD3、SLC3A2、USP28、BCL2L15、DCAF12L1、GSTT1、MERTK、PLD4、SLC40A1、USP29、BCL2L2、DCAF12L2、GSTT2、MESDC1、PLD5、SLC41A1、USP3、BCL2L2-PABPN1、DCAF13、GSTT2B、MESDC2、PLD6、SLC41A2、USP30、BCL3、DCAF15、GSTZ1、MESP1、PLEC、SLC41A3、USP31、BCL6、DCAF16、GSX1、MESP2、PLEK、SLC43A1、USP32、BCL6B、DCAF17、GSX2、MEST、PLEK2、SLC43A2、USP33、BCL7A、DCAF4、GTDC1、MET、PLEKHA1、SLC43A3、
	USP34、BCL7B、DCAF4L1、GTF2A1、METAP1、PLEKHA2、SLC44A1、USP35、BCL7C、DCAF4L2、GTF2A1L、METAP1D、PLEKHA3、SLC44A2、USP36、BCL9、DCAF5、GTF2A2、METAP2、PLEKHA4、SLC44A3、USP37、BCL9L、DCAF6、GTF2B、METRN、PLEKHA5、SLC44A4、USP38、BCLAF1、DCAF7、GTF2E1、METRNL、PLEKHA6、SLC44A5、USP39、BCMO1、DCAF8、GTF2E2、METTL1、PLEKHA7、SLC45A1、USP4、BCO2、DCAF8L1、GTF2F1、METTL10、PLEKHA8、SLC45A2、USP40、BCOR、DCAKD、GTF2F2、METTL11B、PLEKHB1、SLC45A3、USP41、BCORL1、DCBLD1、GTF2H1、METTL12、PLEKHB2、SLC45A4、USP42、BCR、DCBLD2、GTF2H2、METTL13、PLEKHD1、SLC46A1、USP43、BCS1L、DCC、GTF2H2C、METTL14、PLEKHF1、SLC46A2、USP44、BDH1、DCD、GTF2H3、METTL15、PLEKHF2、SLC46A3、USP45、BDH2、DCDC1、GTF2H4、METTL16、PLEKHG1、SLC47A1、USP46、BDKRB1、DCDC2、GTF2H5、METTL17、PLEKHG2、SLC47A2、USP47、BDKRB2、DCDC2B、GTF2I、METTL18、PLEKHG3、SLC48A1、USP48、BDNF、DCDC2C、GTF2IRD1、METTL20、PLEKHG4、SLC4A1、USP49、BDP1、DCDC5、GTF2IRD2、METTL21A、PLEKHG4B、SLC4A10、USP5、BEAN1、DCHS1、GTF2IRD2B、METTL21B、PLEKHG5、SLC4A11、USP50、BECN1、DCHS2、GTF3A、METTL21C、PLEKHG6、SLC4A1AP、USP51、BECN1P1、DCK、GTF3C1、METTL22、PLEKHG7、SLC4A2、USP53、BEGAIN、DCLK1、GTF3C2、METTL23、PLEKHH1、SLC4A3、USP54、BEND2、DCLK2、GTF3C3、METTL24、PLEKHH2、SLC4A4、USP6、BEND3、DCLK3、GTF3C4、METTL25、PLEKHH3、SLC4A5、USP6NL、BEND4、DCLRE1A、GTF3C5、METTL2A、PLEKHJ1、SLC4A7、USP7、BEND5、DCLRE1B、GTF3C6、METTL2B、PLEKHM1、SLC4A8、USP8、BEND6、DCLRE1C、GTPBP1、METTL3、PLEKHM2、SLC4A9、USP9X、BEND7、DCN、GTPBP10、METTL4、PLEKHM3、SLC50A1、USP9Y、BEST1、DCP1A、GTPBP2、METTL5、PLEKHN1、SLC51A、USPL1、BEST2、DCP1B、GTPBP3、METTL6、PLEKHO1、SLC51B、UST、BEST3、DCP2、GTPBP4、METTL7A、PLEKHO2、SLC52A1、UTF1、BEST4、DCPS、GTPBP6、METTL7B、PLEKHS1、SLC52A2、UTP11L、BET1、DCST1、GTPBP8、METTL8、PLET1、SLC52A3、UTP14A、BET1L、DCST2、GTSCR1、METTL9、PLG、SLC5A1、UTP14C、BEX1、DCSTAMP、GTSE1、MEX3A、PLGLB1、SLC5A10、UTP15、BEX2、DCT、GTSF1、MEX3B、PLGLB2、SLC5A11、UTP18、BEX4、DCTD、GTSF1L、MEX3C、PLGRKT、SLC5A12、UTP20、BEX5、DCTN1、GUCA1A、MEX3D、PLIN1、SLC5A2、UTP23、BFAR、DCTN2、GUCA1B、MFAP1、PLIN2、SLC5A3、UTP3、BFSP1、DCTN3、GUCA1C、MFAP2、PLIN3、SLC5A4、UTP6、BFSP2、DCTN4、GUCA2A、MFAP3、PLIN4、SLC5A5、UTRN、BGLAP、DCTN5、GUCA2B、MFAP3L、PLIN5、SLC5A6、UTS2、BGN、DCTN6、GUCD1、MFAP4、PLK1、SLC5A7、UTS2B、BHLHA15、DCTPP1、GUCY1A2、MFAP5、PLK1S1、SLC5A8、UTY、BHLHA9、DCUN1D1、GUCY1A3、MFF、PLK2、SLC5A9、UVRAG、BHLHB9、DCUN1D2、GUCY1B3、MFGE8、PLK3、SLC6A1、UVSSA、BHLHE22、DCUN1D3、GUCY2C、MFHAS1、PLK4、SLC6A11、UXS1、BHLHE23、DCUN1D4、GUCY2D、MFI2、PLK5、SLC6A12、UXT、BHLHE40、DCUN1D5、GUCY2F、MFN1、PLLP、SLC6A13、VAC14、BHLHE41、DCX、GUF1、MFN2、PLN、SLC6A14、VAMP1、BHMT、DCXR、GUK1、MFNG、PLOD1、SLC6A15、VAMP2、BHMT2、DDA1、GULP1、MFRP、PLOD2、SLC6A16、VAMP3、BICC1、DDAH1、GUSB、MFSD1、PLOD3、SLC6A17、VAMP4、BICD1、DDAH2、GXYLT1、MFSD10、PLP1、SLC6A18、VAMP5、BICD2、DDB1、GXYLT2、MFSD11、PLP2、SLC6A19、
VAMP7、BID、DDB2、GYG1、MFSD12、PLRG1、SLC6A2、VAMP8、BIK、DDC、GYG2、MFSD2A、PLS1、SLC6A20、VANGL1、BIN1、DDHD1、GYLTL1B、MFSD2B、PLS3、SLC6A3、VANGL2、BIN2、DDHD2、GYPA、MFSD3、PLSCR1、SLC6A4、VAPA、BIN3、DDI1、GYPB、MFSD4、PLSCR2、SLC6A5、VAPB、BIRC2、DDI2、GYPC、MFSD5、PLSCR3、SLC6A6、VARS、BIRC3、DDIT3、GYPE、MFSD6、PLSCR4、SLC6A7、VARS2、BIRC5、DDIT4、GYS1、MFSD6L、PLSCR5、SLC6A8、VASH1、BIRC6、DDIT4L、GYS2、MFSD7、PLTP、SLC6A9、VASH2、BIRC7、DDN、GZF1、MFSD8、PLVAP、SLC7A1、VASN、BIRC8、DDO、GZMA、MFSD9、PLXDC1、SLC7A10、VASP、BIVM、DDOST、GZMB、MGA、PLXDC2、SLC7A11、VAT1、BIVM-ERCC5、DDR1、GZMH、MGAM、PLXNA1、SLC7A13、VAT1L、BLCAP、DDR2、GZMK、MGARP、PLXNA2、SLC7A14、VAV1、BLID、DDRGK1、GZMM、MGAT1、PLXNA3、SLC7A2、VAV2、BLK、DDT、H1F0、MGAT2、PLXNA4、SLC7A3、VAV3、BLM、DDTL、H1FNT、MGAT3、PLXNB1、SLC7A4、VAX1、BLMH、DDX1、H1FOO、MGAT4A、PLXNB2、SLC7A5、VAX2、BLNK、DDX10、H1FX、MGAT4B、PLXNB3、SLC7A6、VBP1、BLOC1S1、DDX11、H2AFB1、MGAT4C、PLXNC1、SLC7A6OS、VCAM1、BLOC1S2、DDX17、H2AFB2、MGAT5、PLXND1、SLC7A7、VCAN、BLOC1S3、DDX18、H2AFB3、MGAT5B、PM20D1、SLC7A8、VCL、BLOC1S4、DDX19A、H2AFJ、MGEA5、PM20D2、SLC7A9、VCP、BLOC1S5、DDX19B、H2AFV、MGLL、PMAIP1、SLC8A1、VCPIP1、BLOC1S6、DDX20、H2AFX、MGME1、PMCH、SLC8A2、VCPKMT、BLVRA、DDX21、H2AFY、MGMT、PMEL、SLC8A3、VCX、BLVRB、DDX23、H2AFY2、MGP、PMEPA1、SLC8B1、VCX2、BLZF1、DDX24、H2AFZ、MGRN1、PMF1、SLC9A1、VCX3A、BMF、DDX25、H2BFM、MGST1、PMF1-BGLAP、SLC9A2、VCX3B、BMI1、DDX26B、H2BFWT、MGST2、PMFBP1、SLC9A3、VCY、BMP1、DDX27、H3F3A、MGST3、PML、SLC9A3R1、VCY1B、BMP10、DDX28、H3F3B、MIA、PMM1、SLC9A3R2、VDAC1、BMP15、DDX31、H3F3C、MIA2、PMM2、SLC9A4、VDAC2、BMP2、DDX39A、H6PD、MIA3、PMP2、SLC9A5、VDAC3、BMP2K、DDX39B、HAAO、MIB1、PMP22、SLC9A6、VDR、BMP3、DDX3X、HABP2、MIB2、PMPCA、SLC9A7、VEGFA、BMP4、DDX3Y、HABP4、MICA、PMPCB、SLC9A8、VEGFB、BMP5、DDX4、HACE1、MICAL1、PMS1、SLC9A9、VEGFC、BMP6、DDX41、HACL1、MICAL2、PMS2、SLC9B1、VENTX、BMP7、DDX42、HADH、MICAL3、PMVK、SLC9B2、VEPH1、BMP8A、DDX43、HADHA、MICALCL、PNCK、SLC9C1、VEZF1、BMP8B、DDX46、HADHB、MICALL1、PNISR、SLC9C2、VEZT、BMPER、DDX47、HAGH、MICALL2、PNKD、SLCO1A2、VGF、BMPR1A、DDX49、HAGHL、MICB、PNKP、SLCO1B1、VGLL1、BMPR1B、DDX5、HAL、MICU1、PNLDC1、SLCO1B3、VGLL2、BMPR2、DDX50、HAMP、MICU2、PNLIP、SLCO1B7、VGLL3、BMS1、DDX51、HAND1、MICU3、PNLIPRP1、SLCO1C1、VGLL4、BMX、DDX52、HAND2、MID1、PNLIPRP2、SLCO2A1、VHL、BNC1、DDX53、HAO1、MID1IP1、PNLIPRP3、SLCO2B1、VHLL、BNC2、DDX54、HAO2、MID2、PNMA2、SLCO3A1、VIL1、BNIP1、DDX55、HAP1、MIDN、PNMA3、SLCO4A1、VILL、BNIP2、DDX56、HAPLN1、MIEF1、PNMA5、SLCO4C1、VIM、BNIP3、DDX58、HAPLN2、MIEF2、PNMA6A、SLCO5A1、VIMP、BNIP3L、DDX59、HAPLN3、MIEN1、PNMA6C、SLCO6A1、VIP、BNIPL、DDX6、HAPLN4、MIER1、PNMAL1、SLFN11、VIPAS39、BOC、DDX60、HARBI1、MIER2、PNMAL2、SLFN12、VIPR1、BOD1、DDX60L、HARS、MIER3、PNMT、SLFN12L、VIPR2、BOD1L1、DEAF1、HARS2、MIF、PNN、SLFN13、VIT、BOD1L2、1-Dec、HAS1、MIF4GD、PNO1、SLFN14、VKORC1、BOK、DECR1、HAS2、MIIP、PNOC、SLFN5、
	VKORC1L1、BOLA1、DECR2、HAS3、MILR1、PNP、SLFNL1、VLDLR、BOLA2、DEDD、HAT1、MINA、PNPLA1、SLIRP、VMA21、BOLA2B、DEDD2、HAUS1、MINK1、PNPLA2、SLIT1、VMAC、BOLA3、DEF6、HAUS2、MINOS1、PNPLA3、SLIT2、VMO1、BOLL、DEF8、HAUS3、MINOS1-NBL1、PNPLA4、SLIT3、VMP1、BOP1、DEFA1、HAUS4、MINPP1、PNPLA5、SLITRK1、VN1R1、BORA、DEFA1B、HAUS5、MIOS、PNPLA6、SLITRK2、VN1R2、BPGM、DEFA3、HAUS6、MIOX、PNPLA7、SLITRK3、VN1R4、BPHL、DEFA4、HAUS7、MIP、PNPLA8、SLITRK4、VN1R5、BPI、DEFA5、HAUS8、MIPEP、PNPO、SLITRK5、VNN1、BPIFA1、DEFA6、HAVCR1、MIPOL1、PNPT1、SLITRK6、VNN2、BPIFA2、DEFB1、HAVCR2、MIR205HG、PNRC1、SLK、VOPP1、BPIFA3、DEFB103A、HAX1、MIS12、PNRC2、SLMAP、VPRBP、BPIFB1、DEFB103B、HBA1、MIS18A、POC1A、SLMO1、VPREB1、BPIFB2、DEFB104A、HBA2、MIS18BP1、POC1B、SLMO2、VPREB3、BPIFB3、DEFB104B、HBB、MISP、POC1B-GALNT4、SLN、VPS11、BPIFB4、DEFB105A、HBD、MITD1、POC5、SLPI、VPS13A、BPIFB6、DEFB105B、HBE1、MITF、PODN、SLTM、VPS13B、BPIFC、DEFB106A、HBEGF、MIXL1、PODNL1、SLU7、VPS13C、BPNT1、DEFB106B、HBG1、MKI67、PODXL、SLURP1、VPS13D、BPTF、DEFB107A、HBG2、MKKS、PODXL2、SLX1A、VPS16、BPY2、DEFB107B、HBM、MKL1、POF1B、SLX1B、VPS18、BPY2B、DEFB108B、HBP1、MKL2、POFUT1、SLX4、VPS25、BPY2C、DEFB110、HBQ1、MKLN1、POFUT2、SLX4IP、VPS26A、BRAF、DEFB112、HBS1L、MKNK1、POGK、SMAD1、VPS26B、BRAP、DEFB113、HBZ、MKNK2、POGLUT1、SMAD2、VPS28、BRAT1、DEFB114、HCAR1、MKRN1、POGZ、SMAD3、VPS29、BRCA1、DEFB115、HCAR2、MKRN2、POLA1、SMAD4、VPS33A、BRCA2、DEFB116、HCAR3、MKRN3、POLA2、SMAD5、VPS33B、BRCC3、DEFB118、HCCS、MKS1、POLB、SMAD6、VPS35、BRD1、DEFB119、HCFC1、MKX、POLD1、SMAD7、VPS36、BRD2、DEFB121、HCFC1R1、MLANA、POLD2、SMAD9、VPS37A、BRD3、DEFB123、HCFC2、MLC1、POLD3、SMAGP、VPS37B、BRD4、DEFB124、HCK、MLEC、POLD4、SMAP1、VPS37C、BRD7、DEFB125、HCLS1、MLF1、POLDIP2、SMAP2、VPS37D、BRD8、DEFB126、HCN1、MLF2、POLDIP3、SMARCA1、VPS39、BRD9、DEFB127、HCN2、MLH1、POLE、SMARCA2、VPS41、BRDT、DEFB128、HCN3、MLH3、POLE2、SMARCA4、VPS45、BRE、DEFB129、HCN4、MLIP、POLE3、SMARCA5、VPS4A、BRF1、DEFB130、HCRT、MLKL、POLE4、SMARCAD1、VPS4B、BRF2、DEFB131、HCRTR1、MLLT1、POLG、SMARCAL1、VPS51、BRI3、DEFB132、HCRTR2、MLLT10、POLG2、SMARCB1、VPS52、BRI3BP、DEFB133、HCST、MLLT11、POLH、SMARCC1、VPS53、BRICD5、DEFB134、HDAC1、MLLT3、POLI、SMARCC2、VPS54、BRINP1、DEFB135、HDAC10、MLLT4、POLK、SMARCD1、VPS72、BRINP2、DEFB136、HDAC11、MLLT6、POLL、SMARCD2、VPS8、BRINP3、DEFB4A、HDAC2、MLN、POLM、SMARCD3、VPS9D1、BRIP1、DEFB4B、HDAC3、MLNR、POLN、SMARCE1、VRK1、BRIX1、DEGS1、HDAC4、MLPH、POLQ、SMC1A、VRK2、BRK1、DEGS2、HDAC5、MLST8、POLR1A、SMC1B、VRK3、BRMS1、DEK、HDAC6、MLX、POLR1B、SMC2、VRTN、BRMS1L、DENND1A、HDAC7、MLXIP、POLR1C、SMC3、VSIG1、BROX、DENND1B、HDAC8、MLXIPL、POLR1D、SMC4、VSIG10、BRPF1、DENND1C、HDAC9、MLYCD、POLR1E、SMC5、VSIG10L、BRPF3、DENND2A、HDC、MMAA、POLR2A、SMC6、VSIG2、BRS3、DENND2C、HDDC2、MMAB、POLR2B、SMCHD1、VSIG4、BRSK1、DENND2D、HDDC3、MMACHC、POLR2C、SMCO2、VSIG8、BRSK2、DENND3、HDGF、MMADHC、POLR2D、SMCO3、
VSNL1、BRWD1、DENND4A、HDGFL1、MMD、POLR2E、SMCO4、VSTM1、BRWD3、DENND4B、HDGFRP2、MMD2、POLR2F、SMCP、VSTM2A、BSCL2、DENND4C、HDGFRP3、MME、POLR2G、SMCR8、VSTM2B、BSDC1、DENND5A、HDHD1、MMEL1、POLR2H、SMCR9、VSTM2L、BSG、DENND5B、HDHD2、MMGT1、POLR2I、SMDT1、VSTM4、BSN、DENND6A、HDHD3、MMP1、POLR2J、SMEK1、VSTM5、BSND、DENND6B、HDLBP、MMP10、POLR2J2、SMEK2、VSX1、BSPH1、DENR、HDX、MMP11、POLR2J3、SMG1、VSX2、BSPRY、DEPDC1、HEATR1、MMP12、POLR2K、SMG5、VTA1、BST1、DEPDC1B、HEATR2、MMP13、POLR2L、SMG6、VTCN1、BST2、DEPDC4、HEATR3、MMP14、POLR2M、SMG7、VTI1A、BSX、DEPDC5、HEATR4、MMP15、POLR3A、SMG8、VTI1B、BTAF1、DEPDC7、HEATR5A、MMP16、POLR3B、SMG9、VTN、BTBD1、DEPTOR、HEATR5B、MMP17、POLR3C、SMIM1、VWA1、BTBD10、DERA、HEATR6、MMP19、POLR3D、SMIM10、VWA2、BTBD11、DERL1、HEBP1、MMP2、POLR3E、SMIM11、VWA3A、BTBD16、DERL2、HEBP2、MMP20、POLR3F、SMIM12、VWA3B、BTBD17、DERL3、HECA、MMP21、POLR3G、SMIM13、VWA5A、BTBD18、DES、HECTD1、MMP23B、POLR3GL、SMIM14、VWA5B1、BTBD19、DESI1、HECTD2、MMP24、POLR3H、SMIM15、VWA5B2、BTBD2、DESI2、HECTD3、MMP25、POLR3K、SMIM17、VWA7、BTBD3、DET1、HECTD4、MMP26、POLRMT、SMIM18、VWA8、BTBD6、DEXI、HECW1、MMP27、POM121、SMIM19、VWA9、BTBD7、DFFA、HECW2、MMP28、POM121C、SMIM2、VWC2、BTBD8、DFFB、HEG1、MMP3、POM121L12、SMIM20、VWC2L、BTBD9、DFNA5、HELB、MMP7、POM121L2、SMIM21、VWCE、BTC、DFNB31、HELLS、MMP8、POMC、SMIM22、VWDE、BTD、DFNB59、HELQ、MMP9、POMGNT1、SMIM3、VWF、BTF3、DGAT1、HELT、MMRN1、POMGNT2、SMIM4、WAC、BTF3L4、DGAT2、HELZ、MMRN2、POMK、SMIM5、WAPAL、BTG1、DGAT2L6、HELZ2、MMS19、POMP、SMIM6、WARS、BTG2、DGCR14、HEMGN、MMS22L、POMT1、SMIM7、WARS2、BTG3、DGCR2、HEMK1、MN1、POMT2、SMIM8、WAS、BTG4、DGCR6、HENMT1、MNAT1、POMZP3、SMIM9、WASF1、BTK、DGCR6L、HEPACAM、MND1、PON1、SMKR1、WASF2、BTLA、DGCR8、HEPACAM2、MNDA、PON2、SMLR1、WASF3、BTN1A1、DGKA、HEPH、MNS1、PON3、SMN1、WASH1、BTN2A1、DGKB、HEPHL1、MNT、POP1、SMN2、WASL、BTN2A2、DGKD、HEPN1、MNX1、POP4、SMNDC1、WBP1、BTN3A1、DGKE、HERC1、MOAP1、POP5、SMO、WBP11、BTN3A2、DGKG、HERC2、MOB1A、POP7、SMOC1、WBP1L、BTN3A3、DGKH、HERC3、MOB1B、POPDC2、SMOC2、WBP2、BTNL10、DGKI、HERC4、MOB2、POPDC3、SMOX、WBP2NL、BTNL2、DGKK、HERC5、MOB3A、POR、SMPD1、WBP4、BTNL3、DGKQ、HERC6、MOB3B、PORCN、SMPD2、WBP5、BTNL8、DGKZ、HERPUD1、MOB3C、POSTN、SMPD3、WBSCR16、BTNL9、DGUOK、HERPUD2、MOB4、POT1、SMPD4、WBSCR17、BTRC、DHCR24、HES1、MOBP、POTEA、SMPD5、WBSCR22、BUB1、DHCR7、HES2、MOCOS、POTEB、SMPDL3A、WBSCR27、BUB1B、DHDDS、HES3、MOCS1、POTEB2、SMPDL3B、WBSCR28、BUB3、DHDH、HES4、MOCS2、POTEC、SMPX、WDFY1、BUD13、DHFR、HES5、MOCS3、POTED、SMR3A、WDFY2、BUD31、DHFRL1、HES6、MOG、POTEE、SMR3B、WDFY3、BVES、DHH、HES7、MOGAT1、POTEF、SMS、WDFY4、BYSL、DHODH、HESX1、MOGAT2、POTEG、SMTN、WDHD1、BZRAP1、DHPS、HEXA、MOGAT3、POTEH、SMTNL1、WDPCP、BZW1、DHRS1、HEXB、MOGS、POTEI、SMTNL2、WDR1、BZW2、DHRS11、HEXDC、MOK、POTEJ、SMU1、WDR11、C10orf10、DHRS12、HEXIM1、MON1A、POTEM、SMUG1、WDR12、C10orf105、DHRS13、HEXIM2、MON1B、POU1F1、SMURF1、WDR13、
	C10orf107、DHRS2、HEY1、MON2、POU2AF1、SMURF2、WDR16、C10orf11、DHRS3、HEY2、MORC1、POU2F1、SMYD1、WDR17、C10orf111、DHRS4、HEYL、MORC2、POU2F2、SMYD2、WDR18、C10orf112、DHRS4L1、HFE、MORC3、POU2F3、SMYD3、WDR19、C10orf113、DHRS4L2、HFE2、MORC4、POU3F1、SMYD4、WDR20、C10orf118、DHRS7、HFM1、MORF4L1、POU3F2、SMYD5、WDR24、C10orf12、DHRS7B、HGC6.3、MORF4L2、POU3F3、SNAI1、WDR25、C10orf120、DHRS7C、HGD、MORN1、POU3F4、SNAI2、WDR26、C10orf126、DHRS9、HGF、MORN2、POU4F1、SNAI3、WDR27、C10orf128、DHRSX、HGFAC、MORN3、POU4F2、SNAP23、WDR3、C10orf129、DHTKD1、HGS、MORN4、POU4F3、SNAP25、WDR31、C10orf131、DHX15、HGSNAT、MORN5、POU5F1、SNAP29、WDR33、C10orf137、DHX16、HHAT、MOS、POU5F1B、SNAP47、WDR34、C10orf2、DHX29、HHATL、MOSPD1、POU5F2、SNAP91、WDR35、C10orf25、DHX30、HHEX、MOSPD2、POU6F1、SNAPC1、WDR36、C10orf32、DHX32、HHIP、MOSPD3、POU6F2、SNAPC2、WDR37、C10orf35、DHX33、HHIPL1、MOV10、PP2D1、SNAPC3、WDR38、C10orf53、DHX34、HHIPL2、MOV10L1、PPA1、SNAPC4、WDR4、C10orf54、DHX35、HHLA1、MOXD1、PPA2、SNAPC5、WDR41、C10orf55、DHX36、HHLA2、MPC1、PPAN、SNAPIN、WDR43、C10orf62、DHX37、HHLA3、MPC1L、PPAN-P2RY11、SNCA、WDR44、C10orf67、DHX38、HIAT1、MPC2、PPAP2A、SNCAIP、WDR45、C10orf68、DHX40、HIATL1、MPDU1、PPAP2B、SNCB、WDR45B、C10orf71、DHX57、HIBADH、MPDZ、PPAP2C、SNCG、WDR46、C10orf76、DHX58、HIBCH、MPEG1、PPAPDC1A、SND1、WDR47、C10orf82、DHX8、HIC1、MPG、PPAPDC1B、SNED1、WDR48、C10orf88、DHX9、HIC2、MPHOSPH10、PPAPDC2、SNF8、WDR49、C10orf90、DIABLO、HID1、MPHOSPH6、PPAPDC3、SNIP1、WDR5、C10orf91、DIAPH1、HIF1A、MPHOSPH8、PPARA、SNN、WDR52、C10orf95、DIAPH2、HIF1AN、MPHOSPH9、PPARD、SNPH、WDR53、C10orf99、DIAPH3、HIF3A、MPI、PPARG、SNRK、WDR54、C11orf1、DICER1、HIGD1A、MPL、PPARGC1A、SNRNP200、WDR55、C11orf16、DIDO1、HIGD1B、MPLKIP、PPARGC1B、SNRNP25、WDR59、C11orf21、DIEXF、HIGD1C、MPND、PPAT、SNRNP27、WDR5B、C11orf24、DIMT1、HIGD2A、MPO、PPBP、SNRNP35、WDR6、C11orf30、DIO1、HILPDA、MPP1、PPCDC、SNRNP40、WDR60、C11orf31、DIO2、HINFP、MPP2、PPCS、SNRNP48、WDR61、C11orf35、DIO3、HINT1、MPP3、PPDPF、SNRNP70、WDR62、C11orf40、DIP2A、HINT2、MPP4、PPEF1、SNRPA、WDR63、C11orf42、DIP2B、HINT3、MPP5、PPEF2、SNRPA1、WDR64、C11orf44、DIP2C、HIP1、MPP6、PPFIA1、SNRPB、WDR65、C11orf45、DIRAS1、HIP1R、MPP7、PPFIA2、SNRPB2、WDR66、C11orf48、DIRAS2、HIPK1、MPPE1、PPFIA3、SNRPC、WDR7、C11orf49、DIRAS3、HIPK2、MPPED1、PPFIA4、SNRPD1、WDR70、C11orf52、DIRC1、HIPK3、MPPED2、PPFIBP1、SNRPD2、WDR72、C11orf53、DIRC2、HIPK4、MPRIP、PPFIBP2、SNRPD3、WDR73、C11orf54、DIS3、HIRA、MPST、PPHLN1、SNRPE、WDR74、C11orf57、DIS3L、HIRIP3、MPV17、PPIA、SNRPF、WDR75、C11orf58、DIS3L2、HIST1H1A、MPV17L、PPIAL4A、SNRPG、WDR76、C11orf63、DISC1、HIST1H1B、MPV17L2、PPIAL4B、SNRPN、WDR77、C11orf65、DISP1、HIST1H1C、MPZ、PPIAL4C、SNTA1、WDR78、C11orf68、DISP2、HIST1H1D、MPZL1、PPIAL4D、SNTB1、WDR81、C11orf70、DIXDC1、HIST1H1E、MPZL2、PPIAL4E、SNTB2、WDR82、C11orf71、DKC1、
HIST1H1T、MPZL3、PPIAL4F、SNTG1、WDR83、C11orf73、DKK1、HIST1H2AA、MR1、PPIAL4G、SNTG2、WDR83OS、C11orf74、DKK2、HIST1H2AB、MRAP、PPIB、SNTN、WDR86、C11orf80、DKK3、HIST1H2AC、MRAP2、PPIC、SNUPN、WDR87、C11orf82、DKK4、HIST1H2AD、MRAS、PPID、SNURF、WDR88、C11orf83、DKKL1、HIST1H2AE、MRC2、PPIE、SNW1、WDR89、C11orf84、DLAT、HIST1H2AG、MRE11A、PPIF、SNX1、WDR90、C11orf85、DLC1、HIST1H2AH、MREG、PPIG、SNX10、WDR91、C11orf86、DLD、HIST1H2AI、MRFAP1、PPIH、SNX11、WDR92、C11orf87、DLEC1、HIST1H2AJ、MRFAP1L1、PPIL1、SNX12、WDR93、C11orf88、DLEU7、HIST1H2AK、MRGBP、PPIL2、SNX13、WDR96、C11orf91、DLG1、HIST1H2AL、MRGPRD、PPIL3、SNX14、WDSUB1、C11orf94、DLG2、HIST1H2AM、MRGPRE、PPIL4、SNX15、WDTC1、C11orf95、DLG3、HIST1H2BA、MRGPRF、PPIL6、SNX16、WDYHV1、C11orf96、DLG4、HIST1H2BB、MRGPRG、PPIP5K1、SNX17、WEE1、C12orf10、DLG5、HIST1H2BC、MRGPRX1、PPIP5K2、SNX18、WEE2、C12orf23、DLGAP1、HIST1H2BD、MRGPRX2、PPL、SNX19、WFDC1、C12orf29、DLGAP2、HIST1H2BE、MRGPRX3、PPM1A、SNX2、WFDC10A、C12orf39、DLGAP4、HIST1H2BF、MRGPRX4、PPM1B、SNX20、WFDC10B、C12orf4、DLGAP5、HIST1H2BG、MRI1、PPM1D、SNX21、WFDC11、C12orf40、DLK1、HIST1H2BH、MRM1、PPM1E、SNX22、WFDC12、C12orf42、DLK2、HIST1H2BI、MRO、PPM1F、SNX24、WFDC13、C12orf43、DLL1、HIST1H2BJ、MROH1、PPM1G、SNX25、WFDC2、C12orf44、DLL3、HIST1H2BK、MROH2A、PPM1H、SNX27、WFDC3、C12orf45、DLL4、HIST1H2BL、MROH2B、PPM1J、SNX29、WFDC5、C12orf49、DLST、HIST1H2BM、MROH5、PPM1K、SNX3、WFDC6、C12orf5、DLX1、HIST1H2BN、MROH6、PPM1L、SNX30、WFDC8、C12orf50、DLX2、HIST1H2BO、MROH7、PPM1M、SNX31、WFDC9、C12orf52、DLX3、HIST1H3A、MROH8、PPM1N、SNX32、WFIKKN1、C12orf54、DLX4、HIST1H3B、MROH9、PPME1、SNX33、WFIKKN2、C12orf55、DLX5、HIST1H3C、MRP63、PPOX、SNX4、WFS1、C12orf56、DLX6、HIST1H3D、MRPL1、PPP1CA、SNX5、WHAMM、C12orf57、DMAP1、HIST1H3E、MRPL10、PPP1CB、SNX6、WHSC1、C12orf60、DMBT1、HIST1H3F、MRPL11、PPP1CC、SNX7、WHSC1L1、C12orf61、DMBX1、HIST1H3G、MRPL12、PPP1R10、SNX8、WIBG、C12orf65、DMC1、HIST1H3H、MRPL13、PPP1R11、SNX9、WIF1、C12orf66、DMD、HIST1H3I、MRPL14、PPP1R12A、SOAT1、WIPF1、C12orf68、DMGDH、HIST1H3J、MRPL15、PPP1R12B、SOAT2、WIPF2、C12orf71、DMKN、HIST1H4A、MRPL16、PPP1R12C、SOBP、WIPF3、C12orf73、DMP1、HIST1H4B、MRPL17、PPP1R13B、SOCS1、WIPI1、C12orf74、DMPK、HIST1H4C、MRPL18、PPP1R13L、SOCS2、WIPI2、C12orf75、DMRT1、HIST1H4D、MRPL19、PPP1R14A、SOCS3、WISP1、C12orf76、DMRT2、HIST1H4E、MRPL2、PPP1R14B、SOCS4、WISP2、C12orf77、DMRT3、HIST1H4F、MRPL20、PPP1R14C、SOCS5、WISP3、C12orf79、DMRTA1、HIST1H4G、MRPL21、PPP1R14D、SOCS6、WIZ、C12orf80、DMRTA2、HIST1H4H、MRPL22、PPP1R15A、SOCS7、WLS、C13orf35、DMRTB1、HIST1H4I、MRPL23、PPP1R15B、SOD1、WNK1、C13orf45、DMRTC1、HIST1H4J、MRPL24、PPP1R16A、SOD2、WNK2、C14orf1、DMRTC1B、HIST1H4K、MRPL27、PPP1R16B、SOD3、WNK3、C14orf105、DMRTC2、HIST1H4L、MRPL28、PPP1R17、SOGA1、WNK4、C14orf119、DMTF1、HIST2H2AA3、MRPL3、PPP1R18、SOGA2、WNT1、C14orf132、DMTN、HIST2H2AA4、
	MRPL30、PPP1R1A、SOGA3、WNT10A、C14orf142、DMWD、HIST2H2AB、MRPL32、PPP1R1B、SOHLH1、WNT10B、C14orf159、DMXL1、HIST2H2AC、MRPL33、PPP1R1C、SOHLH2、WNT11、C14orf164、DMXL2、HIST2H2BE、MRPL34、PPP1R2、SON、WNT16、C14orf166、DNA2、HIST2H2BF、MRPL35、PPP1R21、SORBS1、WNT2、C14orf166B、DNAAF1、HIST2H3A、MRPL36、PPP1R26、SORBS2、WNT2B、C14orf169、DNAAF2、HIST2H3C、MRPL37、PPP1R27、SORBS3、WNT3、C14orf177、DNAAF3、HIST2H3D、MRPL38、PPP1R32、SORCS1、WNT3A、C14orf178、DNAH1、HIST2H4A、MRPL39、PPP1R35、SORCS2、WNT4、C14orf180、DNAH10、HIST2H4B、MRPL4、PPP1R36、SORCS3、WNT5A、C14orf182、DNAH11、HIST3H2A、MRPL40、PPP1R37、SORD、WNT5B、C14orf183、DNAH12、HIST3H2BB、MRPL41、PPP1R3A、SORL1、WNT6、C14orf2、DNAH14、HIST3H3、MRPL42、PPP1R3B、SORT1、WNT7A、C14orf28、DNAH17、HIST4H4、MRPL43、PPP1R3C、SOS1、WNT7B、C14orf37、DNAH2、HIVEP1、MRPL44、PPP1R3D、SOS2、WNT8A、C14orf39、DNAH3、HIVEP2、MRPL45、PPP1R3E、SOST、WNT8B、C14orf79、DNAH5、HIVEP3、MRPL46、PPP1R3F、SOSTDC1、WNT9A、C14orf80、DNAH6、HJURP、MRPL47、PPP1R3G、SOWAHA、WNT9B、C14orf93、DNAH7、HK1、MRPL48、PPP1R42、SOWAHB、WRAP53、C15orf26、DNAH8、HK2、MRPL49、PPP1R7、SOWAHC、WRAP73、C15orf27、DNAH9、HK3、MRPL50、PPP1R8、SOWAHD、WRB、C15orf32、DNAI1、HKDC1、MRPL51、PPP1R9A、SOX1、WRN、C15orf38、DNAI2、HKR1、MRPL52、PPP1R9B、SOX10、WRNIP1、C15orf38-AP3S2、DNAJA1、HLa-a、MRPL53、PPP2CA、SOX11、WSB1、C15orf39、DNAJA2、HLA-B、MRPL54、PPP2CB、SOX12、WSB2、C15orf40、DNAJA3、HLA-C、MRPL55、PPP2R1A、SOX13、WSCD1、C15orf41、DNAJA4、HLA-DMA、MRPL9、PPP2R1B、SOX14、WSCD2、C15orf43、DNAJB1、HLA-DMB、MRPS10、PPP2R2A、SOX15、WT1、C15orf48、DNAJB11、HLA-DOA、MRPS11、PPP2R2B、SOX17、WTAP、C15orf52、DNAJB12、HLA-DOB、MRPS12、PPP2R2C、SOX18、WTH3DI、C15orf53、DNAJB13、HLA-DPA1、MRPS14、PPP2R2D、SOX2、WTIP、C15orf54、DNAJB14、HLA-DPB1、MRPS15、PPP2R3A、SOX21、WWC1、C15orf56、DNAJB2、HLA- DQA1、MRPS16、PPP2R3B、SOX3、WWC2、C15orf57、DNAJB3、HLA-DQA2、MRPS17、PPP2R3C、SOX30、WWC3、C15orf59、DNAJB4、HLA-DQB1、MRPS18A、PPP2R4、SOX4、WWOX、C15orf60、DNAJB5、HLA- DQB2、MRPS18B、PPP2R5A、SOX5、WWP1、C15orf61、DNAJB6、HLA-DRA、MRPS18C、PPP2R5B、SOX6、WWP2、C15orf62、DNAJB7、HLA-DRB1、MRPS2、PPP2R5C、SOX7、WWTR1、C15orf65、DNAJB8、HLA- DRB5、MRPS21、PPP2R5D、SOX8、XAB2、C16orf11、DNAJB9、HLA-E、MRPS22、PPP2R5E、SOX9、XAF1、C16orf13、DNAJC1、HLA-F、MRPS23、PPP3CA、SP1、XAGE1D、C16orf3、DNAJC10、HLA-G、MRPS24、PPP3CB、SP100、XAGE2、C16orf45、DNAJC11、HLCS、MRPS25、PPP3CC、SP110、XAGE3、C16orf46、DNAJC12、HLF、MRPS26、PPP3R1、SP140、XAGE5、C16orf47、DNAJC13、HLTF、MRPS27、PPP3R2、SP140L、XBP1、C16orf52、DNAJC14、HLX、MRPS28、PPP4C、SP2、XCL1、C16orf54、DNAJC15、HM13、MRPS30、PPP4R1、SP3、XCL2、C16orf58、DNAJC16、HMBOX1、MRPS31、PPP4R2、SP4、XCR1、C16orf59、DNAJC17、HMBS、MRPS33、PPP4R4、SP5、XDH、C16orf62、DNAJC18、HMCES、MRPS34、PPP5C、SP6、XG、C16orf70、DNAJC19、HMCN1、MRPS35、PPP5D1、SP7、XIAP、C16orf71、DNAJC2、HMCN2、MRPS36、
PPP6C、SP8、XIRP1、C16orf72、DNAJC21、HMG20A、MRPS5、PPP6R1、SP9、XIRP2、C16orf74、DNAJC22、HMG20B、MRPS6、PPP6R2、SPA17、XK、C16orf78、DNAJC24、HMGA1、MRPS7、PPP6R3、SPACA1、XKR3、C16orf80、DNAJC25、HMGA2、MRPS9、PPRC1、SPACA3、XKR4、C16orf82、DNAJC25-GNG10、HMGB1、MRRF、PPT1、SPACA4、XKR5、C16orf86、DNAJC27、HMGB2、MRS2、PPT2、SPACA5、XKR6、C16orf87、DNAJC28、HMGB3、MRTO4、PPTC7、SPACA5B、XKR7、C16orf89、DNAJC3、HMGB4、MRVI1、PPWD1、SPACA7、XKR8、C16orf90、DNAJC30、HMGCL、MS4A1、PPY、SPAG1、XKR9、C16orf91、DNAJC4、HMGCLL1、MS4A10、PQBP1、SPAG11A、XKRX、C16orf92、DNAJC5、HMGCR、MS4A12、PQLC1、SPAG11B、XKRY、C16orf93、DNAJC5B、HMGCS1、MS4A13、PQLC2、SPAG16、XKRY2、C16orf95、DNAJC5G、HMGCS2、MS4A14、PQLC3、SPAG17、XPA、C16orf96、DNAJC6、HMGN1、MS4A15、PRAC1、SPAG4、XPC、C16orf97、DNAJC7、HMGN2、MS4A2、PRAC2、SPAG5、XPNPEP1、C17orf100、DNAJC8、HMGN3、MS4A3、PRADC1、SPAG6、XPNPEP2、C17orf102、DNAJC9、HMGN4、MS4A4A、PRAF2、SPAG7、XPNPEP3、C17orf103、DNAL1、HMGN5、MS4A4E、PRAM1、SPAG8、XPO1、C17orf104、DNAL4、HMGXB3、MS4A5、PRAME、SPAG9、XPO4、C17orf105、DNALI1、HMGXB4、MS4A6A、PRAMEF1、SPAM1、XPO5、C17orf107、DNASE1、HMHA1、MS4A6E、PRAMEF10、SPANXA1、XPO6、C17orf112、DNASE1L1、HMHB1、MS4A7、PRAMEF11、SPANXA2、XPO7、C17orf47、DNASE1L2、HMMR、MS4A8、PRAMEF12、SPANXB1、XPOT、C17orf49、DNASE1L3、HMOX1、MSANTD1、PRAMEF13、SPANXB2、XPR1、C17orf50、DNASE2、HMOX2、MSANTD2、PRAMEF14、SPANXC、XRCC1、C17orf51、DNASE2B、HMP19、MSANTD3、PRAMEF15、SPANXD、XRCC2、C17orf53、DND1、HMSD、MSANTD3-TMEFF1、PRAMEF16、SPANXN1、XRCC3、C17orf58、DNER、HMX1、MSANTD4、PRAMEF17、SPANXN2、XRCC4、C17orf59、DNHD1、HMX2、MSC、PRAMEF18、SPANXN3、XRCC5、C17orf62、DNLZ、HMX3、MSGN1、PRAMEF19、SPANXN4、XRCC6、C17orf64、DNM1、HN1、MSH2、PRAMEF2、SPANXN5、XRCC6BP1、C17orf66、DNM1L、HN1L、MSH3、PRAMEF20、SPARC、XRN1、C17orf67、DNM2、HNF1A、MSH4、PRAMEF21、SPARCL1、XRN2、C17orf70、DNM3、HNF1B、MSH5、PRAMEF22、SPAST、XRRA1、C17orf72、DNMBP、HNF4A、MSH6、PRAMEF23、SPATA1、XXYLT1、C17orf74、DNMT1、HNF4G、MSI1、PRAMEF25、SPATA12、XYLB、C17orf75、DNMT3A、HNMT、MSI2、PRAMEF3、SPATA13、XYLT1、C17orf77、DNMT3B、HNRNPA0、MSL1、PRAMEF4、SPATA16、XYLT2、C17orf78、DNMT3L、HNRNPA1、MSL2、PRAMEF5、SPATA17、YAE1D1、C17orf80、DNPEP、HNRNPA1L2、MSL3、PRAMEF6、SPATA18、YAF2、C17orf82、DNPH1、HNRNPA2B1、MSLN、PRAMEF7、SPATA19、YAP1、C17orf85、DNTT、HNRNPA3、MSMB、PRAMEF8、SPATA2、YARS、C17orf89、DNTTIP1、HNRNPAB、MSMO1、PRAMEF9、SPATA20、YARS2、C17orf96、DNTTIP2、HNRNPC、MSMP、PRAP1、SPATA21、YBEY、C17orf97、DOC2A、HNRNPCL1、MSN、PRB1、SPATA22、YBX1、C17orf98、DOC2B、HNRNPCP5、MSR1、PRB2、SPATA24、YBX2、C17orf99、DOCK1、HNRNPD、MSRA、PRB3、SPATA25、YBX3、C18orf21、DOCK10、HNRNPDL、MSRB1、PRB4、SPATA2L、YDJC、C18orf25、DOCK11、HNRNPF、MSRB2、PRC1、SPATA3、YEATS2、C18orf32、DOCK2、HNRNPH1、MSRB3、PRCC、SPATA31A1、YEATS4、C18orf42、DOCK3、HNRNPH2、MSS51、PRCD、SPATA31A2、YES1、C18orf54、DOCK4、
	HNRNPH3、MST1、PRCP、SPATA31A3、YIF1A、C18orf56、DOCK5、HNRNPK、MST1L、PRDM1、SPATA31A4、YIF1B、C18orf63、DOCK6、HNRNPL、MST1R、PRDM10、SPATA31A5、YIPF1、C18orf8、DOCK7、HNRNPLL、MST4、PRDM11、SPATA31A6、YIPF2、C19orf10、DOCK8、HNRNPM、MSTN、PRDM12、SPATA31A7、YIPF3、C19orf12、DOCK9、HNRNPR、MSTO1、PRDM13、SPATA31C1、YIPF4、C19orf18、DOHH、HNRNPU、MSX1、PRDM14、SPATA31C2、YIPF5、C19orf24、DOK1、HNRNPUL1、MSX2、PRDM15、SPATA31D1、YIPF6、C19orf25、DOK2、HNRNPUL2、MT1A、PRDM16、SPATA31D3、YIPF7、C19orf26、DOK3、HOGA1、MT1B、PRDM2、SPATA31D4、YJEFN3、C19orf33、DOK4、HOMER1、MT1E、PRDM4、SPATA31E1、YKT6、C19orf35、DOK5、HOMER2、MT1F、PRDM5、SPATA32、YLPM1、C19orf38、DOK6、HOMER3、MT1G、PRDM6、SPATA33、YME1L1、C19orf40、DOK7、HOMEZ、MT1H、PRDM7、SPATA4、YOD1、C19orf43、DOLK、HOOK1、MT1HL1、PRDM8、SPATA5、YPEL1、C19orf44、DOLPP1、HOOK2、MT1M、PRDM9、SPATA5L1、YPEL2、C19orf45、DONSON、HOOK3、MT1X、PRDX1、SPATA6、YPEL3、C19orf47、DOPEY1、HOPX、MT2A、PRDX2、SPATA6L、YPEL4、C19orf48、DOPEY2、HORMAD1、MT3、PRDX3、SPATA7、YPEL5、C19orf52、DOT1L、HORMAD2、MT4、PRDX4、SPATA8、YRDC、C19orf53、DPAGT1、HOXA1、MTA1、PRDX5、SPATA9、YTHDC1、C19orf54、DPCD、HOXA10、MTA2、PRDX6、SPATC1、YTHDC2、C19orf55、DPCR1、HOXA11、MTA3、PREB、SPATC1L、YTHDF1、C19orf57、DPEP1、HOXA13、MTAP、PRELID1、SPATS1、YTHDF2、C19orf59、DPEP2、HOXA2、MTBP、PRELID2、SPATS2、YTHDF3、C19orf60、DPEP3、HOXA3、MTCH1、PRELP、SPATS2L、YWHAB、C19orf66、DPF1、HOXA4、MTCH2、PREP、SPC24、YWHAE、C19orf67、DPF2、HOXA5、MTCP1、PREPL、SPC25、YWHAG、C19orf68、DPF3、HOXA6、MTDH、PREX1、SPCS1、YWHAH、C19orf69、DPH1、HOXA7、MTERF、PREX2、SPCS2、YWHAQ、C19orf70、DPH2、HOXA9、MTERFD1、PRF1、SPCS3、YWHAZ、C19orf71、DPH3、HOXB1、MTERFD2、PRG2、SPDEF、YY1、C19orf73、DPH3P1、HOXB13、MTERFD3、PRG3、SPDL1、YY1AP1、C19orf77、DPH5、HOXB2、MTF1、PRG4、SPDYA、YY2、C19orf80、DPH6、HOXB3、MTF2、PRH1、SPDYC、ZACN、C19orf81、DPH7、HOXB4、MTFMT、PRH2、SPDYE1、ZADH2、C19orf82、DPM1、HOXB5、MTFP1、PRICKLE1、SPDYE2、ZAK、C1D、DPM2、HOXB6、MTFR1、PRICKLE2、SPDYE2B、ZAN、C1GALT1、DPM3、HOXB7、MTFR1L、PRICKLE3、SPDYE3、ZAP70、C1GALT1C1、DPP10、HOXB8、MTFR2、PRICKLE4、SPDYE4、ZAR1、C1orf100、DPP3、HOXB9、MTG1、PRIM1、SPDYE5、ZAR1L、C1orf101、DPP4、HOXC10、MTG2、PRIM2、SPDYE6、ZBBX、C1orf105、DPP6、HOXC11、MTHFD1、PRIMA1、SPECC1、ZBED1、C1orf106、DPP7、HOXC12、MTHFD1L、PRIMPOL、SPECC1L、ZBED2、C1orf109、DPP8、HOXC13、MTHFD2、PRKAA1、SPEF1、ZBED3、C1orf110、DPP9、HOXC4、MTHFD2L、PRKAA2、SPEF2、ZBED4、C1orf111、DPPA2、HOXC5、MTHFR、PRKAB1、SPEG、ZBED5、C1orf112、DPPA3、HOXC6、MTHFS、PRKAB2、SPEM1、ZBED6、C1orf115、DPPA4、HOXC8、MTHFSD、PRKACA、SPEN、ZBED6CL、C1orf116、DPPA5、HOXC9、MTIF2、PRKACB、SPERT、ZBP1、C1orf122、DPRX、HOXD1、MTIF3、PRKACG、SPESP1、ZBTB1、C1orf123、DPT、HOXD10、MTL5、PRKAG1、SPG11、ZBTB10、C1orf127、DPY19L1、HOXD11、MTM1、PRKAG2、SPG20、ZBTB11、C1orf131、DPY19L2、HOXD12、MTMR1、PRKAG3、SPG21、ZBTB12、C1orf137、DPY19L3、HOXD13、
MTMR10、PRKAR1A、SPG7、ZBTB14、C1orf141、DPY19L4、HOXD3、MTMR11、PRKAR1B、SPHAR、ZBTB16、C1orf146、DPY30、HOXD4、MTMR12、PRKAR2A、SPHK1、ZBTB17、C1orf158、DPYD、HOXD8、MTMR14、PRKAR2B、SPHK2、ZBTB18、C1orf159、DPYS、HOXD9、MTMR2、PRKCA、SPHKAP、ZBTB2、C1orf162、DPYSL2、HP、MTMR3、PRKCB、SPI1、ZBTB20、C1orf167、DPYSL3、HP1BP3、MTMR4、PRKCD、SPIB、ZBTB21、C1orf168、DPYSL4、HPCA、MTMR6、PRKCDBP、SPIC、ZBTB22、C1orf172、DPYSL5、HPCAL1、MTMR7、PRKCE、SPICE1、ZBTB24、C1orf173、DQX1、HPCAL4、MTMR8、PRKCG、SPIDR、ZBTB25、C1orf174、DR1、HPD、MTMR9、PRKCH、SPIN1、ZBTB26、C1orf177、DRAM1、HPDL、MTNR1A、PRKCI、SPIN2A、ZBTB3、C1orf185、DRAM2、HPGD、MTNR1B、PRKCQ、SPIN2B、ZBTB32、C1orf186、DRAP1、HPGDS、MTO1、PRKCSH、SPIN3、ZBTB33、C1orf189、DRAXIN、HPN、MTOR、PRKCZ、SPIN4、ZBTB34、C1orf192、DRC1、HPR、MTPAP、PRKD1、SPINK1、ZBTB37、C1orf194、DRD1、HPRT1、MTPN、PRKD2、SPINK13、ZBTB38、C1orf195、DRD2、HPS1、MTR、PRKD3、SPINK14、ZBTB39、C1orf198、DRD3、HPS3、MTRF1、PRKDC、SPINK2、ZBTB4、C1orf204、DRD4、HPS4、MTRF1L、PRKG1、SPINK4、ZBTB40、C1orf21、DRD5、HPS5、MTRNR2L10、PRKG2、SPINK5、ZBTB41、C1orf210、DRG1、HPS6、MTRNR2L2、PRKRA、SPINK6、ZBTB42、C1orf216、DRG2、HPSE、MTRNR2L3、PRKRIP1、SPINK7、ZBTB43、C1orf226、DRGX、HPSE2、MTRNR2L4、PRKRIR、SPINK8、ZBTB44、C1orf227、DROSHA、HPX、MTRNR2L5、PRKX、SPINK9、ZBTB45、C1orf228、DRP2、HR、MTRNR2L6、PRL、SPINT1、ZBTB46、C1orf229、DSC1、HRAS、MTRNR2L7、PRLH、SPINT2、ZBTB47、C1orf233、DSC2、HRASLS、MTRNR2L9、PRLHR、SPINT3、ZBTB48、C1orf234、DSC3、HRASLS2、MTRR、PRLR、SPINT4、ZBTB49、C1orf27、DSCAM、HRASLS5、MTSS1、PRM1、SPIRE1、ZBTB5、C1orf35、DSCAML1、HRC、MTSS1L、PRM2、SPIRE2、ZBTB6、C1orf43、DSCC1、HRCT1、MTTP、PRM3、SPN、ZBTB7A、C1orf50、DSCR3、HRG、MTURN、PRMT1、SPNS1、ZBTB7B、C1orf51、DSCR4、HRH1、MTUS1、PRMT10、SPNS2、ZBTB7C、C1orf52、DSE、HRH2、MTUS2、PRMT2、SPNS3、ZBTB8A、C1orf53、DSEL、HRH3、MTX1、PRMT3、SPO11、ZBTB8B、C1orf54、DSG1、HRH4、MTX2、PRMT5、SPOCD1、ZBTB8OS、C1orf56、DSG2、HRK、MTX3、PRMT6、SPOCK1、ZBTB9、C1orf61、DSG3、HRNR、MUC1、PRMT7、SPOCK2、ZC2HC1A、C1orf63、DSG4、HRSP12、MUC12、PRMT8、SPOCK3、ZC2HC1B、C1orf64、DSN1、HS1BP3、MUC13、PRND、SPON1、ZC2HC1C、C1orf65、DSP、HS2ST1、MUC15、PRNP、SPON2、ZC3H10、C1orf68、DSPP、HS3ST1、MUC16、PROB1、SPOP、ZC3H11A、C1orf74、DST、HS3ST2、MUC17、PROC、SPOPL、ZC3H12A、C1orf85、DSTN、HS3ST3A1、MUC19、PROCA1、SPP1、ZC3H12B、C1orf86、DSTNP4、HS3ST3B1、MUC2、PROCR、SPP2、ZC3H12C、C1orf87、DSTYK、HS3ST4、MUC20、PRODH、SPPL2A、ZC3H12D、C1orf94、DTD1、HS3ST5、MUC21、PRODH2、SPPL2B、ZC3H13、C1orf95、DTD2、HS3ST6、MUC22、PROK1、SPPL2C、ZC3H14、C1QA、DTHD1、HS6ST1、MUC3A、PROK2、SPPL3、ZC3H15、C1QB、DTL、HS6ST2、MUC4、PROKR1、SPR、ZC3H18、C1QBP、DTNA、HS6ST3、MUC5AC、PROKR2、SPRED1、ZC3H3、C1QC、DTNB、HSBP1、MUC5B、PROL1、SPRED2、ZC3H4、C1QL1、DTNBP1、HSBP1L1、MUC6、PROM1、SPRED3、ZC3H6、C1QL2、DTWD1、HSCB、MUC7、PROM2、SPRN、ZC3H7A、C1QL3、DTWD2、HSD11B1、MUC8、PROP1、SPRR1A、ZC3H7B、
	C1QL4、DTX1、HSD11B1L、MUCL1、PROS1、SPRR1B、ZC3H8、C1QTNF1、DTX2、HSD11B2、MUL1、PROSC、SPRR2A、ZC3HAV1、C1QTNF2、DTX3、HSD17B1、MUM1、PROSER1、SPRR2B、ZC3HAV1L、C1QTNF3、DTX3L、HSD17B10、MUM1L1、PROSER2、SPRR2D、ZC3HC1、C1QTNF4、DTX4、HSD17B11、MURC、PROX1、SPRR2E、ZC4H2、C1QTNF5、DTYMK、HSD17B12、MUS81、PROX2、SPRR2F、ZCCHC10、C1QTNF6、DUOX1、HSD17B13、MUSK、PROZ、SPRR2G、ZCCHC11、C1QTNF7、DUOX2、HSD17B14、MUSTN1、PRPF18、SPRR3、ZCCHC12、C1QTNF8、DUOXA1、HSD17B2、MUT、PRPF19、SPRR4、ZCCHC13、C1QTNF9、DUOXA2、HSD17B3、MUTYH、PRPF3、SPRTN、ZCCHC14、C1QTNF9B、DUPD1、HSD17B4、MVB12A、PRPF31、SPRY1、ZCCHC16、C1QTNF9B-AS1、DUS1L、HSD17B6、MVB12B、PRPF38A、SPRY2、ZCCHC17、C1R、DUS2、HSD17B7、MVD、PRPF38B、SPRY3、ZCCHC18、C1RL、DUS3L、HSD17B8、MVK、PRPF39、SPRY4、ZCCHC2、C1S、DUS4L、HSD3B1、MVP、PRPF4、SPRYD3、ZCCHC24、C2、DUSP1、HSD3B2、MX1、PRPF40A、SPRYD4、ZCCHC3、C20orf112、DUSP10、HSD3B7、MX2、PRPF40B、SPRYD7、ZCCHC4、C20orf141、DUSP11、HSDL1、MXD1、PRPF4B、SPSB1、ZCCHC5、C20orf144、DUSP12、HSDL2、MXD3、PRPF6、SPSB2、ZCCHC6、C20orf166、DUSP13、HSF1、MXD4、PRPF8、SPSB3、ZCCHC7、C20orf173、DUSP14、HSF2、MXI1、PRPH、SPSB4、ZCCHC8、C20orf194、DUSP15、HSF2BP、MXRA5、PRPH2、SPTA1、ZCCHC9、C20orf195、DUSP16、HSF4、MXRA7、PRPS1、SPTAN1、ZCRB1、C20orf196、DUSP18、HSF5、MXRA8、PRPS1L1、SPTB、ZCWPW1、C20orf197、DUSP19、HSFX1、MYADM、PRPS2、SPTBN1、ZCWPW2、C20orf201、DUSP2、HSFX2、MYADML2、PRPSAP1、SPTBN2、ZDBF2、C20orf202、DUSP21、HSFY1、MYB、PRPSAP2、SPTBN4、ZDHHC1、C20orf203、DUSP22、HSFY2、MYBBP1A、PRR11、SPTBN5、ZDHHC11、C20orf24、DUSP23、HSH2D、MYBL1、PRR12、SPTLC1、ZDHHC11B、C20orf26、DUSP26、HSP90AA1、MYBL2、PRR13、SPTLC2、ZDHHC12、C20orf27、DUSP27、HSP90AB1、MYBPC1、PRR14、SPTLC3、ZDHHC13、C20orf62、DUSP28、HSP90B1、MYBPC2、PRR14L、SPTSSA、ZDHHC14、C20orf78、DUSP3、HSPA12A、MYBPC3、PRR15、SPTSSB、ZDHHC15、C20orf85、DUSP4、HSPA12B、MYBPH、PRR15L、SPTY2D1、ZDHHC16、C20orf96、DUSP5、HSPA13、MYBPHL、PRR16、SPZ1、ZDHHC17、C21orf140、DUSP6、HSPA14、MYC、PRR18、SQLE、ZDHHC18、C21orf2、DUSP7、HSPA1A、MYCBP、PRR19、SQRDL、ZDHHC19、C21orf33、DUSP8、HSPA1B、MYCBP2、PRR20A、SQSTM1、ZDHHC2、C21orf58、DUSP9、HSPA1L、MYCBPAP、PRR20B、SRA1、ZDHHC20、C21orf59、DUT、HSPA2、MYCL、PRR20C、SRBD1、ZDHHC21、C21orf62、DUXA、HSPA4、MYCN、PRR20D、SRC、ZDHHC22、C21orf91、DVL1、HSPA4L、MYCT1、PRR20E、SRCAP、ZDHHC23、C22orf15、DVL2、HSPA5、MYD88、PRR21、SRCIN1、ZDHHC24、C22orf23、DVL3、HSPA6、MYEF2、PRR22、SRCRB4D、ZDHHC3、C22orf24、DXO、HSPA8、MYEOV、PRR23A、SRD5A1、ZDHHC4、C22orf26、DYDC1、HSPA9、MYEOV2、PRR23B、SRD5A2、ZDHHC5、C22orf29、DYDC2、HSPB1、MYF5、PRR23C、SRD5A3、ZDHHC6、C22orf31、DYM、HSPB11、MYF6、PRR24、SREBF1、ZDHHC7、C22orf39、DYNAP、HSPB2、MYH1、PRR25、SREBF2、ZDHHC8、C22orf42、DYNC1H1、HSPB3、MYH10、PRR3、SREK1、ZDHHC9、C22orf43、DYNC1I1、HSPB6、MYH11、PRR30、SREK1IP1、ZEB1、C22orf46、DYNC1I2、HSPB7、MYH13、PRR4、SRF、ZEB2、C2CD2、DYNC1LI1、HSPB8、
MYH14、PRR5、SRFBP1、ZER1、C2CD2L、DYNC1LI2、HSPB9、MYH15、PRR5-ARHGAP8、SRGAP1、ZFAND1、C2CD3、DYNC2H1、HSPBAP1、MYH2、PRR5L、SRGAP2、ZFAND2A、C2CD4A、DYNC2LI1、HSPBP1、MYH3、PRR7、SRGAP2B、ZFAND2B、C2CD4B、DYNLL1、HSPD1、MYH4、PRR9、SRGAP2C、ZFAND3、C2CD4C、DYNLL2、HSPE1、MYH6、PRRC1、SRGAP3、ZFAND4、C2CD4D、DYNLRB1、HSPE1-MOB4、MYH7、PRRC2A、SRGN、ZFAND5、C2CD5、DYNLRB2、HSPG2、MYH7B、PRRC2B、SRI、ZFAND6、C2orf15、DYNLT1、HSPH1、MYH8、PRRC2C、SRL、ZFAT、C2orf16、DYNLT3、HTATIP2、MYH9、PRRG1、SRM、ZFC3H1、C2orf27A、DYRK1A、HTATSF1、MYL1、PRRG2、SRMS、ZFHX2、C2orf27B、DYRK1B、HTN1、MYL10、PRRG3、SRP14、ZFHX3、C2orf40、DYRK2、HTN3、MYL12A、PRRG4、SRP19、ZFHX4、C2orf42、DYRK3、HTR1A、MYL12B、PRRT1、SRP54、ZFP1、C2orf43、DYRK4、HTR1B、MYL2、PRRT2、SRP68、ZFP14、C2orf44、DYSF、HTR1D、MYL3、PRRT3、SRP72、ZFP2、C2orf47、DYTN、HTR1E、MYL4、PRRT4、SRP9、ZFP28、C2orf48、DYX1C1、HTR1F、MYL5、PRRX1、SRPK1、ZFP3、C2orf49、DZANK1、HTR2A、MYL6、PRRX2、SRPK2、ZFP30、C2orf50、DZIP1、HTR2B、MYL6B、PRSS1、SRPK3、ZFP36、C2orf53、DZIP1L、HTR2C、MYL7、PRSS12、SRPR、ZFP36L1、C2orf54、DZIP3、HTR3A、MYL9、PRSS16、SRPRB、ZFP36L2、C2orf57、E2F1、HTR3B、MYLIP、PRSS2、SRPX、ZFP37、C2orf61、E2F2、HTR3C、MYLK、PRSS21、SRPX2、ZFP41、C2orf62、E2F3、HTR3D、MYLK2、PRSS22、SRR、ZFP42、C2orf66、E2F4、HTR3E、MYLK3、PRSS23、SRRD、ZFP57、C2orf68、E2F5、HTR4、MYLK4、PRSS27、SRRM1、ZFP62、C2orf69、E2F6、HTR5A、MYLPF、PRSS3、SRRM2、ZFP64、C2orf70、E2F7、HTR6、MYNN、PRSS33、SRRM3、ZFP69、C2orf71、E2F8、HTR7、MYO10、PRSS35、SRRM4、ZFP69B、C2orf72、E4F1、HTRA1、MYO15A、PRSS36、SRRM5、ZFP82、C2orf73、EAF1、HTRA2、MYO16、PRSS37、SRRT、ZFP90、C2orf74、EAF2、HTRA3、MYO18A、PRSS38、SRSF1、ZFP91、C2orf76、EAPP、HTRA4、MYO18B、PRSS41、SRSF10、ZFP92、C2orf78、EARS2、HTT、MYO19、PRSS42、SRSF11、ZFPL1、C2orf80、EBAG9、HUNK、MYO1A、PRSS44、SRSF12、ZFPM1、C2orf81、EBF1、HUS1、MYO1B、PRSS45、SRSF2、ZFPM2、C2orf82、EBF2、HUS1B、MYO1C、PRSS46、SRSF3、ZFR、C2orf83、EBF3、HUWE1、MYO1D、PRSS48、SRSF4、ZFR2、C2orf88、EBF4、HVCN1、MYO1E、PRSS50、SRSF5、ZFX、C2orf91、EBI3、HYAL1、MYO1F、PRSS53、SRSF6、ZFY、C3、EBLN1、HYAL2、MYO1G、PRSS54、SRSF7、ZFYVE1、C3AR1、EBLN2、HYAL3、MYO1H、PRSS55、SRSF8、ZFYVE16、C3orf14、EBNA1BP2、HYAL4、MYO3A、PRSS56、SRSF9、ZFYVE19、C3orf17、EBP、HYDIN、MYO3B、PRSS57、SRXN1、ZFYVE20、C3orf18、EBPL、HYI、MYO5A、PRSS58、SRY、ZFYVE21、C3orf20、ECD、HYKK、MYO5B、PRSS8、SS18、ZFYVE26、C3orf22、ECE1、HYLS1、MYO5C、PRTFDC1、SS18L1、ZFYVE27、C3orf27、ECE2、HYOU1、MYO6、PRTG、SS18L2、ZFYVE28、C3orf30、ECEL1、HYPK、MYO7A、PRTN3、SSB、ZFYVE9、C3orf33、ECH1、IAH1、MYO7B、PRUNE、SSBP1、ZG16、C3orf35、ECHDC1、IAPP、MYO9A、PRUNE2、SSBP2、ZG16B、C3orf36、ECHDC2、IARS、MYO9B、PRX、SSBP3、ZGLP1、C3orf38、ECHDC3、IARS2、MYOC、PRY、SSBP4、ZGPAT、C3orf43、ECHS1、IBA57、MYOCD、PRY2、SSC5D、ZHX1、C3orf52、ECI1、IBSP、MYOD1、PSAP、SSFA2、ZHX1-C8ORF76、C3orf55、ECI2、IBTK、MYOF、PSAPL1、SSH1、ZHX2、C3orf56、ECM1、ICA1、MYOG、PSAT1、SSH2、
	ZHX3、C3orf58、ECM2、ICA1L、MYOM1、PSCA、SSH3、ZIC1、C3orf62、ECSCR、ICAM1、MYOM2、PSD、SSMEM1、ZIC2、C3orf67、ECSIT、ICAM2、MYOM3、PSD2、SSNA1、ZIC3、C3orf70、ECT2、ICAM3、MYOT、PSD3、SSPN、ZIC4、C3orf72、ECT2L、ICAM4、MYOZ1、PSD4、SSPO、ZIC5、C3orf79、EDA、ICAM5、MYOZ2、PSEN1、SSR1、ZIK1、C3orf80、EDA2R、ICK、MYOZ3、PSEN2、SSR2、ZIM2、C3orf83、EDAR、ICMT、MYPN、PSENEN、SSR3、ZIM3、C3orf84、EDARADD、ICOS、MYPOP、PSG1、SSR4、ZKSCAN1、C4A、EDC3、ICOSLG、MYRF、PSG11、SSRP1、ZKSCAN2、C4B、EDC4、ICT1、MYRFL、PSG2、SSSCA1、ZKSCAN3、C4B_2、EDDM3A、ID1、MYRIP、PSG3、SST、ZKSCAN4、C4BPA、EDDM3B、ID2、MYSM1、PSG4、SSTR1、ZKSCAN5、C4BPB、EDEM1、ID3、MYT1、PSG5、SSTR2、ZKSCAN7、C4orf17、EDEM2、ID4、MYT1L、PSG6、SSTR3、ZKSCAN8、C4orf19、EDEM3、IDE、MYZAP、PSG7、SSTR4、ZMAT1、C4orf21、EDF1、IDH1、MZB1、PSG8、SSTR5、ZMAT2、C4orf22、EDIL3、IDH2、MZF1、PSG9、SSU72、ZMAT3、C4orf26、EDN1、IDH3A、MZT1、PSIP1、SSUH2、ZMAT4、C4orf27、EDN2、IDH3B、MZT2A、PSKH1、SSX1、ZMAT5、C4orf29、EDN3、IDH3G、MZT2B、PSKH2、SSX2、ZMIZ1、C4orf3、EDNRA、IDI1、N4BP1、PSMA1、SSX2B、ZMIZ2、C4orf32、EDNRB、IDI2、N4BP2、PSMA2、SSX2IP、ZMPSTE24、C4orf33、EEA1、IDNK、N4BP2L1、PSMA3、SSX3、ZMYM1、C4orf36、EED、IDO1、N4BP2L2、PSMA4、SSX4、ZMYM2、C4orf40、EEF1A1、IDO2、N4BP3、PSMA5、SSX4B、ZMYM3、C4orf45、EEF1A2、IDS、N6AMT1、PSMA6、SSX5、ZMYM4、C4orf46、EEF1B2、IDUA、N6AMT2、PSMA7、SSX7、ZMYM5、C4orf47、EEF1D、IER2、NAA10、PSMA8、ST13、ZMYM6、C4orf48、EEF1E1、IER3、NAA11、PSMB1、ST14、ZMYM6NB、C4orf50、EEF1G、IER3IP1、NAA15、PSMB10、ST18、ZMYND10、C4orf51、EEF2、IER5、NAA16、PSMB11、ST20、ZMYND11、C4orf6、EEF2K、IER5L、NAA20、PSMB2、ST20-MTHFS、ZMYND12、C5、EEFSEC、IFFO1、NAA25、PSMB3、ST3GAL1、ZMYND15、C5AR1、EEPD1、IFFO2、NAA30、PSMB4、ST3GAL2、ZMYND19、C5AR2、EFCAB1、IFI16、NAA35、PSMB5、ST3GAL3、ZMYND8、C5orf15、EFCAB11、IFI27、NAA38、PSMB6、ST3GAL4、ZNF10、C5orf20、EFCAB12、IFI27L1、NAA40、PSMB7、ST3GAL5、ZNF100、C5orf22、EFCAB13、IFI27L2、NAA50、PSMB8、ST3GAL6、ZNF101、C5orf24、EFCAB14、IFI30、NAA60、PSMB9、ST5、ZNF106、C5orf28、EFCAB2、IFI35、NAAA、PSMC1、ST6GAL1、ZNF107、C5orf30、EFCAB3、IFI44、NAALAD2、PSMC2、ST6GAL2、ZNF112、C5orf34、EFCAB4A、IFI44L、NAALADL1、PSMC3、ST6GALNAC1、ZNF114、C5orf38、EFCAB4B、IFI6、NAALADL2、PSMC3IP、ST6GALNAC2、ZNF117、C5orf42、EFCAB5、IFIH1、NAB1、PSMC4、ST6GALNAC3、ZNF12、C5orf45、EFCAB6、IFIT1、NAB2、PSMC5、ST6GALNAC4、ZNF121、C5orf46、EFCAB7、IFIT1B、NABP1、PSMC6、ST6GALNAC5、ZNF124、C5orf47、EFCAB8、IFIT2、NABP2、PSMD1、ST6GALNAC6、ZNF131、C5orf48、EFCAB9、IFIT3、NACA、PSMD10、ST7、ZNF132、C5orf49、EFCC1、IFIT5、NACA2、PSMD11、ST7L、ZNF133、C5orf50、EFEMP1、IFITM1、NACAD、PSMD12、ST8SIA1、ZNF134、C5orf51、EFEMP2、IFITM10、NACC1、PSMD13、ST8SIA2、ZNF135、C5orf52、EFHB、IFITM2、NACC2、PSMD14、ST8SIA3、ZNF136、C5orf55、EFHC1、IFITM3、NADK、PSMD2、ST8SIA4、ZNF138、C5orf58、EFHC2、IFITM5、NADK2、PSMD3、ST8SIA5、ZNF14、C5orf60、EFHD1、IFLTD1、NADSYN1、PSMD4、ST8SIA6、ZNF140、C5orf63、EFHD2、
IFNA1、NAE1、PSMD5、STAB1、ZNF141、C5orf64、EFNA1、IFNA10、NAF1、PSMD6、STAB2、ZNF142、C6、EFNA2、IFNA13、NAGA、PSMD7、STAC、ZNF143、C6orf1、EFNA3、IFNA14、NAGK、PSMD8、STAC2、ZNF146、C6orf10、EFNA4、IFNA16、NAGLU、PSMD9、STAC3、ZNF148、C6orf106、EFNA5、IFNA17、NAGPA、PSME1、STAG1、ZNF154、C6orf118、EFNB1、IFNA2、NAGS、PSME2、STAG2、ZNF155、C6orf132、EFNB2、IFNA21、NAIF1、PSME3、STAG3、ZNF157、C6orf136、EFNB3、IFNA4、NAIP、PSME4、STAM、ZNF16、C6orf141、EFR3A、IFNA5、NALCN、PSMF1、STAM2、ZNF160、C6orf15、EFR3B、IFNA6、NAMPT、PSMG1、STAMBP、ZNF165、C6orf163、EFS、IFNA7、NANOG、PSMG2、STAMBPL1、ZNF169、C6orf165、EFTUD1、IFNA8、NANOGNB、PSMG3、STAP1、ZNF17、C6orf183、EFTUD2、IFNAR1、NANOS1、PSMG4、STAP2、ZNF174、C6orf195、EGF、IFNAR2、NANOS2、PSORS1C1、STAR、ZNF175、C6orf201、EGFL6、IFNB1、NANOS3、PSORS1C2、STARD10、ZNF177、C6orf203、EGFL7、IFNE、NANP、PSPC1、STARD13、ZNF18、C6orf211、EGFL8、IFNG、NANS、PSPH、STARD3、ZNF180、C6orf222、EGFLAM、IFNGR1、NAP1L1、PSPN、STARD3NL、ZNF181、C6orf223、EGFR、IFNGR2、NAP1L2、PSRC1、STARD4、ZNF182、C6orf226、EGLN1、IFNK、NAP1L3、PSTK、STARD5、ZNF184、C6orf25、EGLN2、IFNL1、NAP1L4、PSTPIP1、STARD6、ZNF185、C6orf47、EGLN3、IFNL2、NAP1L5、PSTPIP2、STARD7、ZNF189、C6orf48、EGR1、IFNL3、NAPA、PTAFR、STARD8、ZNF19、C6orf52、EGR2、IFNL4、NAPB、PTAR1、STARD9、ZNF195、C6orf57、EGR3、IFNLR1、NAPEPLD、PTBP1、STAT1、ZNF197、C6orf58、EGR4、IFNW1、NAPG、PTBP2、STAT2、ZNF2、C6orf62、EHBP1、IFRD1、NAPRT1、PTBP3、STAT3、ZNF20、C6orf7、EHBP1L1、IFRD2、NAPSA、PTCD1、STAT4、ZNF200、C6orf89、EHD1、IFT122、NARF、PTCD2、STAT5A、ZNF202、C6orf99、EHD2、IFT140、NARFL、PTCD3、STAT5B、ZNF205、C7、EHD3、IFT172、NARG2、PTCH1、STAT6、ZNF207、C7orf10、EHD4、IFT20、NARR、PTCH2、STATH、ZNF208、C7orf25、EHF、IFT27、NARS、PTCHD1、STAU1、ZNF211、C7orf26、EHHADH、IFT43、NARS2、PTCHD2、STAU2、ZNF212、C7orf31、EHMT1、IFT46、NASP、PTCHD3、STBD1、ZNF213、C7orf33、EHMT2、IFT52、NAT1、PTCHD4、STC1、ZNF214、C7orf34、EI24、IFT57、NAT10、PTCRA、STC2、ZNF215、C7orf43、EID1、IFT74、NAT14、PTDSS1、STEAP1、ZNF217、C7orf49、EID2、IFT80、NAT16、PTDSS2、STEAP1B、ZNF219、C7orf50、EID2B、IFT81、NAT2、PTEN、STEAP2、ZNF22、C7orf55、EID3、IFT88、NAT6、PTER、STEAP3、ZNF221、C7orf55- LUC7L2、EIF1、IGBP1、NAT8、PTF1A、STEAP4、ZNF222、C7orf57、EIF1AD、IGDCC3、NAT8B、PTGDR、STH、ZNF223、C7orf60、EIF1AX、IGDCC4、NAT8L、PTGDR2、STIL、ZNF224、C7orf61、EIF1AY、IGF1、NAT9、PTGDS、STIM1、ZNF225、C7orf62、EIF1B、IGF1R、NAV1、PTGER1、STIM2、ZNF226、C7orf63、EIF2A、IGF2、NAV2、PTGER2、STIP1、ZNF227、C7orf65、EIF2AK1、IGF2BP1、NAV3、PTGER3、STK10、ZNF229、C7orf66、EIF2AK2、IGF2BP2、NBAS、PTGER4、STK11、ZNF23、C7orf69、EIF2AK3、IGF2BP3、NBEA、PTGES、STK11IP、ZNF230、C7orf71、EIF2AK4、IGF2R、NBEAL1、PTGES2、STK16、ZNF232、C7orf72、EIF2B1、IGFALS、NBEAL2、PTGES3、STK17A、ZNF233、C7orf73、EIF2B2、IGFBP1、NBL1、PTGES3L、STK17B、ZNF234、C7orf76、EIF2B3、IGFBP2、NBN、PTGES3L-AARSD1、STK19、ZNF235、C8A、
	EIF2B4、IGFBP3、NBPF14、PTGFR、STK24、ZNF236、C8B、EIF2B5、IGFBP4、NBPF3、PTGFRN、STK25、ZNF239、C8G、EIF2D、IGFBP5、NBPF4、PTGIR、STK3、ZNF24、C8orf22、EIF2S1、IGFBP6、NBPF6、PTGIS、STK31、ZNF248、C8orf31、EIF2S2、IGFBP7、NBPF7、PTGR1、STK32A、ZNF25、C8orf33、EIF2S3、IGFBPL1、NBR1、PTGR2、STK32B、ZNF250、C8orf34、EIF3A、IGFL1、NCALD、PTGS1、STK32C、ZNF251、C8orf37、EIF3B、IGFL2、NCAM1、PTGS2、STK33、ZNF253、C8orf4、EIF3C、IGFL3、NCAM2、PTH、STK35、ZNF254、C8orf44、EIF3CL、IGFL4、NCAN、PTH1R、STK36、ZNF256、C8orf44-SGK3、EIF3D、IGFLR1、NCAPD2、PTH2、STK38、ZNF257、C8orf46、EIF3E、IGFN1、NCAPD3、PTH2R、STK38L、ZNF259、C8orf47、EIF3F、IGHMBP2、NCAPG、PTHLH、STK39、ZNF26、C8orf48、EIF3G、IGIP、NCAPG2、PTK2、STK4、ZNF260、C8orf58、EIF3H、IGJ、NCAPH、PTK2B、STK40、ZNF263、C8orf59、EIF3I、IGLL1、NCAPH2、PTK6、STMN1、ZNF264、C8orf74、EIF3J、IGLL5、NCBP1、PTK7、STMN2、ZNF266、C8orf76、EIF3K、IGLON5、NCBP2、PTMA、STMN3、ZNF267、C8orf82、EIF3L、IGSF1、NCCRP1、PTMS、STMN4、ZNF268、C8orf86、EIF3M、IGSF10、NCDN、PTN、STMND1、ZNF273、C8orf87、EIF4A1、IGSF11、NCEH1、PTOV1、STOM、ZNF274、C9、EIF4A2、IGSF21、NCF1、PTP4A1、STOML1、ZNF275、C9orf106、EIF4A3、IGSF22、NCF2、PTP4A2、STOML2、ZNF276、C9orf114、EIF4B、IGSF23、NCF4、PTP4A3、STOML3、ZNF277、C9orf116、EIF4E、IGSF3、NCK1、PTPDC1、STON1、ZNF28、C9orf117、EIF4E1B、IGSF5、NCK2、PTPLA、STON1-GTF2A1L、ZNF280A、C9orf129、EIF4E2、IGSF6、NCKAP1、PTPLAD1、STON2、ZNF280B、C9orf131、EIF4E3、IGSF8、NCKAP1L、PTPLAD2、STOX1、ZNF280C、C9orf135、EIF4EBP1、IGSF9、NCKAP5、PTPLB、STOX2、ZNF280D、C9orf139、EIF4EBP2、IGSF9B、NCKAP5L、PTPMT1、STPG1、ZNF281、C9orf142、EIF4EBP3、IHH、NCKIPSD、PTPN1、STPG2、ZNF282、C9orf152、EIF4ENIF1、IK、NCL、PTPN11、STRA13、ZNF283、C9orf153、EIF4G1、IKBIP、NCLN、PTPN12、STRA6、ZNF284、C9orf156、EIF4G2、IKBKAP、NCMAP、PTPN13、STRA8、ZNF285、C9orf16、EIF4G3、IKBKB、NCOA1、PTPN14、STRADA、ZNF286A、C9orf163、EIF4H、IKBKE、NCOA2、PTPN18、STRADB、ZNF286B、C9orf169、EIF5、IKBKG、NCOA3、PTPN2、STRAP、ZNF287、C9orf170、EIF5A、IKZF1、NCOA4、PTPN20A、STRBP、ZNF292、C9orf171、EIF5A2、IKZF2、NCOA5、PTPN20B、STRC、ZNF296、C9orf173、EIF5AL1、IKZF3、NCOA6、PTPN21、STRIP1、ZNF3、C9orf24、EIF5B、IKZF4、NCOA7、PTPN22、STRIP2、ZNF30、C9orf3、EIF6、IKZF5、NCOR1、PTPN23、STRN、ZNF300、C9orf37、ELAC1、INTERLEUKIN、IL10、NCOR2、PTPN3、STRN3、ZNF302、C9orf40、ELAC2、IL10RA、NCR1、PTPN4、STRN4、ZNF304、C9orf41、ELANE、IL10RB、NCR2、PTPN5、STS、ZNF311、C9orf43、ELAVL1、IL11、NCR3、PTPN6、STT3A、ZNF316、C9orf47、ELAVL2、IL11RA、NCR3LG1、PTPN7、STT3B、ZNF317、C9orf50、ELAVL3、IL12A、NCS1、PTPN9、STUB1、ZNF318、C9orf57、ELAVL4、IL12B、NCSTN、PTPRA、STX10、ZNF319、C9orf62、ELF1、IL12RB1、NDC1、PTPRB、STX11、ZNF32、C9orf64、ELF2、IL12RB2、NDC80、PTPRC、STX12、ZNF320、C9orf66、ELF3、IL13、NDE1、PTPRCAP、STX16、ZNF322、C9orf69、ELF4、IL13RA1、NDEL1、PTPRD、STX17、ZNF324、C9orf72、ELF5、IL13RA2、NDFIP1、PTPRE、STX18、ZNF324B、C9orf78、ELFN1、IL15、NDFIP2、PTPRF、STX19、
ZNF326、C9orf84、ELFN2、IL15RA、NDN、PTPRG、STX1A、ZNF329、C9orf85、ELK1、IL16、NDNF、PTPRH、STX1B、ZNF330、C9orf89、ELK3、IL17A、NDNL2、PTPRJ、STX2、ZNF331、C9orf9、ELK4、IL17B、NDOR1、PTPRK、STX3、ZNF333、C9orf91、ELL、IL17C、NDP、PTPRM、STX4、ZNF334、C9orf92、ELL2、IL17D、NDRG1、PTPRN、STX5、ZNF335、C9orf96、ELL3、IL17F、NDRG2、PTPRN2、STX6、ZNF337、CA1、ELMO1、IL17RA、NDRG3、PTPRO、STX7、ZNF33A、CA10、ELMO2、IL17RB、NDRG4、PTPRQ、STX8、ZNF33B、CA11、ELMO3、IL17RC、NDST1、PTPRR、STXBP1、ZNF34、CA12、ELMOD1、IL17RD、NDST2、PTPRS、STXBP2、ZNF341、CA13、ELMOD2、IL17RE、NDST3、PTPRT、STXBP3、ZNF343、CA14、ELMOD3、IL17REL、NDST4、PTPRU、STXBP4、ZNF345、CA2、ELMSAN1、IL18、NDUFA1、PTPRZ1、STXBP5、ZNF346、CA3、ELN、IL18BP、NDUFA10、PTRF、STXBP5L、ZNF347、CA4、ELOF1、IL18R1、NDUFA11、PTRH1、STXBP6、ZNF35、CA5A、ELOVL1、IL18RAP、NDUFA12、PTRH2、STYK1、ZNF350、CA5B、ELOVL2、IL19、NDUFA13、PTRHD1、STYX、ZNF354A、CA6、ELOVL3、IL1A、NDUFA2、PTS、STYXL1、ZNF354B、CA7、ELOVL4、IL1B、NDUFA3、PTTG1、SUB1、ZNF354C、CA8、ELOVL5、IL1F10、NDUFA4、PTTG1IP、SUCLA2、ZNF358、CA9、ELOVL6、IL1R1、NDUFA4L2、PTTG2、SUCLG1、ZNF362、CAAP1、ELOVL7、IL1R2、NDUFA5、PTX3、SUCLG2、ZNF365、CAB39、ELP2、IL1RAP、NDUFA6、PTX4、SUCNR1、ZNF366、CAB39L、ELP3、IL1RAPL1、NDUFA7、PUF60、SUCO、ZNF367、CABIN1、ELP4、IL1RAPL2、NDUFA8、PUM1、SUDS3、ZNF37A、CABLES1、ELP5、IL1RL1、NDUFA9、PUM2、SUFU、ZNF382、CABLES2、ELP6、IL1RL2、NDUFAB1、PURA、SUGP1、ZNF383、CABP1、ELSPBP1、IL1RN、NDUFAF1、PURB、SUGP2、ZNF384、CABP2、ELTD1、IL2、NDUFAF2、PURG、SUGT1、ZNF385A、CABP4、EMB、IL20、NDUFAF3、PUS1、SULF1、ZNF385B、CABP5、EMC1、IL20RA、NDUFAF4、PUS10、SULF2、ZNF385C、CABP7、EMC10、IL20RB、NDUFAF5、PUS3、SULT1A1、ZNF385D、CABS1、EMC2、IL21、NDUFAF6、PUS7、SULT1A2、ZNF391、CABYR、EMC3、IL21R、NDUFAF7、PUS7L、SULT1A3、ZNF394、CACFD1、EMC4、IL22、NDUFB1、PUSL1、SULT1A4、ZNF395、CACHD1、EMC6、IL22RA1、NDUFB10、PVALB、SULT1B1、ZNF396、CACNA1A、EMC7、IL22RA2、NDUFB11、PVR、SULT1C2、ZNF397、CACNA1B、EMC8、IL23A、NDUFB2、PVRIG、SULT1C3、ZNF398、CACNA1C、EMC9、IL23R、NDUFB3、PVRL1、SULT1C4、ZNF404、CACNA1D、EMCN、IL24、NDUFB4、PVRL2、SULT1E1、ZNF407、CACNA1E、EMD、IL25、NDUFB5、PVRL3、SULT2A1、ZNF408、CACNA1F、EME1、IL26、NDUFB6、PVRL4、SULT2B1、ZNF41、CACNA1G、EME2、IL27、NDUFB7、PWP1、SULT4A1、ZNF410、CACNA1H、EMG1、IL27RA、NDUFB8、PWP2、SULT6B1、ZNF414、CACNA1I、EMID1、IL2RA、NDUFB9、PWWP2A、SUMF1、ZNF415、CACNA1S、EMILIN1、IL2RB、NDUFC1、PWWP2B、SUMF2、ZNF416、CACNA2D1、EMILIN2、IL2RG、NDUFC2、PXDC1、SUMO1、ZNF417、CACNA2D2、EMILIN3、IL3、NDUFC2-KCTD14、PXDN、SUMO2、ZNF418、CACNA2D3、EML1、IL31、NDUFS1、PXDNL、SUMO3、ZNF419、CACNA2D4、EML2、IL31RA、NDUFS2、PXK、SUMO4、ZNF420、CACNB1、EML3、IL32、NDUFS3、PXMP2、SUN1、ZNF423、CACNB2、EML4、IL33、NDUFS4、PXMP4、SUN2、ZNF425、CACNB3、EML5、IL34、NDUFS5、PXN、SUN3、ZNF426、CACNB4、EML6、IL36A、NDUFS6、PXT1、SUN5、ZNF428、CACNG1、EMP1、IL36B、NDUFS7、PYCARD、SUOX、ZNF429、CACNG2、EMP2、IL36G、
	NDUFS8、PYCR1、SUPT16H、ZNF43、CACNG3、EMP3、IL36RN、NDUFV1、PYCR2、SUPT20H、ZNF430、CACNG4、EMR1、IL37、NDUFV2、PYCRL、SUPT3H、ZNF431、CACNG5、EMR2、IL3RA、NDUFV3、PYDC1、SUPT4H1、ZNF432、CACNG6、EMR3、IL4、NEB、PYDC2、SUPT5H、ZNF433、CACNG7、EMX1、IL4I1、NEBL、PYGB、SUPT6H、ZNF436、CACNG8、EMX2、IL4R、NECAB1、PYGL、SUPT7L、ZNF438、CACTIN、EN1、IL5、NECAB2、PYGM、SUPV3L1、ZNF439、CACUL1、EN2、IL5RA、NECAB3、PYGO1、SURF1、ZNF44、CACYBP、ENAH、IL6、NECAP1、PYGO2、SURF2、ZNF440、CAD、ENAM、IL6R、NECAP2、PYHIN1、SURF4、ZNF441、CADM1、ENC1、IL6ST、NEDD1、PYROXD1、SURF6、ZNF442、CADM2、ENDOD1、IL7、NEDD4、PYROXD2、SUSD1、ZNF443、CADM3、ENDOG、IL7R、NEDD4L、PYURF、SUSD2、ZNF444、CADM4、ENDOU、IL8、NEDD8、PYY、SUSD3、ZNF445、CADPS、ENDOV、IL9、NEDD8-MDP1、PZP、SUSD4、ZNF446、CADPS2、ENG、IL9R、NEDD9、QARS、SUSD5、ZNF449、CAGE1、ENGASE、ILDR1、NEFH、QDPR、SUV39H1、ZNF45、CALB1、ENHO、ILDR2、NEFL、QKI、SUV39H2、ZNF451、CALB2、ENKD1、ILF2、NEFM、QPCT、SUV420H1、ZNF454、CALCA、ENKUR、ILF3、NEGR1、QPCTL、SUV420H2、ZNF460、CALCB、ENO1、ILK、NEIL1、QPRT、SUZ12、ZNF461、CALCOCO1、ENO2、ILKAP、NEIL2、QRFP、SV2A、ZNF462、CALCOCO2、ENO3、ILVBL、NEIL3、QRFPR、SV2B、ZNF467、CALCR、ENO4、IMMP1L、NEK1、QRICH1、SV2C、ZNF468、CALCRL、ENOPH1、IMMP2L、NEK10、QRICH2、SVEP1、ZNF469、CALD1、ENOSF1、IMMT、NEK11、QRSL1、SVIL、ZNF470、CALHM1、ENOX1、IMP3、NEK2、QSER1、SVIP、ZNF471、CALHM2、ENOX2、IMP4、NEK3、QSOX1、SVOP、ZNF473、CALHM3、ENPEP、IMPA1、NEK4、QSOX2、SVOPL、ZNF474、CALM1、ENPP1、IMPA2、NEK5、QTRT1、SWAP70、ZNF479、CALM2、ENPP2、IMPACT、NEK6、QTRTD1、SWI5、ZNF48、CALM3、ENPP3、IMPAD1、NEK7、R3HCC1、SWSAP1、ZNF480、CALML3、ENPP4、IMPDH1、NEK8、R3HCC1L、SWT1、ZNF483、CALML4、ENPP5、IMPDH2、NEK9、R3HDM1、SYAP1、ZNF484、CALML5、ENPP6、IMPG1、NELFA、R3HDM2、SYBU、ZNF485、CALML6、ENPP7、IMPG2、NELFB、R3HDM4、SYCE1、ZNF486、CALN1、ENSA、INA、NELFCD、R3HDML、SYCE1L、ZNF488、CALR、ENTHD1、INADL、NELFE、RAB10、SYCE2、ZNF490、CALR3、ENTHD2、INCA1、NELL1、RAB11A、SYCE3、ZNF491、CALU、ENTPD1、INCENP、NELL2、RAB11B、SYCN、ZNF492、CALY、ENTPD2、INF2、NEMF、RAB11FIP1、SYCP1、ZNF493、CAMK1、ENTPD3、ING1、NENF、RAB11FIP2、SYCP2、ZNF496、CAMK1D、ENTPD4、ING2、NEO1、RAB11FIP3、SYCP2L、ZNF497、CAMK1G、ENTPD5、ING3、NES、RAB11FIP4、SYCP3、ZNF500、CAMK2A、ENTPD6、ING4、NET1、RAB11FIP5、SYDE1、ZNF501、CAMK2B、ENTPD7、ING5、NETO1、RAB12、SYDE2、ZNF502、CAMK2D、ENTPD8、INHA、NETO2、RAB13、SYF2、ZNF503、CAMK2G、ENY2、INHBA、NEU1、RAB14、SYK、ZNF506、CAMK2N1、EOGT、INHBB、NEU2、RAB15、SYMPK、ZNF507、CAMK2N2、EOMES、INHBC、NEU3、RAB17、SYN1、ZNF510、CAMK4、EP300、INHBE、NEU4、RAB18、SYN2、ZNF511、CAMKK1、EP400、INIP、NEURL1、RAB19、SYN3、ZNF512、CAMKK2、EPAS1、INMT、NEURL1B、RAB1A、SYNC、ZNF512B、CAMKMT、EPB41、INO80、NEURL2、RAB1B、SYNCRIP、ZNF513、CAMKV、EPB41L1、INO80B、NEURL3、RAB20、SYNDIG1、ZNF514、CAMLG、EPB41L2、INO80C、NEURL4、RAB21、SYNDIG1L、ZNF516、CAMP、EPB41L3、INO80D、NEUROD1、RAB22A、SYNE1、ZNF517、CAMSAP1、EPB41L4A、
INO80E、NEUROD2、RAB23、SYNE2、ZNF518A、CAMSAP2、EPB41L4B、INPP1、NEUROD4、RAB24、SYNE3、ZNF518B、CAMSAP3、EPB41L5、INPP4A、NEUROD6、RAB25、SYNE4、ZNF519、CAMTA1、EPB42、INPP4B、NEUROG1、RAB26、SYNGAP1、ZNF521、CAMTA2、EPC1、INPP5A、NEUROG2、RAB27A、SYNGR1、ZNF524、CAND1、EPC2、INPP5B、NEUROG3、RAB27B、SYNGR2、ZNF526、CAND2、EPCAM、INPP5D、NEXN、RAB28、SYNGR3、ZNF527、CANT1、EPDR1、INPP5E、NF1、RAB2A、SYNGR4、ZNF528、CANX、EPG5、INPP5F、NF2、RAB2B、SYNJ1、ZNF529、CAP1、EPGN、INPP5J、NFAM1、RAB30、SYNJ2、ZNF530、CAP2、EPHA1、INPP5K、NFASC、RAB31、SYNJ2BP、ZNF532、CAPG、EPHA10、INPPL1、NFAT5、RAB32、SYNJ2BP-COX16、ZNF534、CAPN1、EPHA2、INS、NFATC1、RAB33A、SYNM、ZNF536、CAPN10、EPHA3、INSC、NFATC2、RAB33B、SYNPO、ZNF540、CAPN11、EPHA4、INSIG1、NFATC2IP、RAB34、SYNPO2、ZNF541、CAPN12、EPHA5、INSIG2、NFATC3、RAB35、SYNPO2L、ZNF543、CAPN13、EPHA6、INS-IGF2、NFATC4、RAB36、SYNPR、ZNF544、CAPN14、EPHA7、INSL3、NFE2、RAB37、SYNRG、ZNF546、CAPN15、EPHA8、INSL4、NFE2L1、RAB38、SYP、ZNF547、CAPN2、EPHB1、INSL5、NFE2L2、RAB39A、SYPL1、ZNF548、CAPN3、EPHB2、INSL6、NFE2L3、RAB39B、SYPL2、ZNF549、CAPN5、EPHB3、INSM1、NFIA、RAB3A、SYS1、ZNF550、CAPN6、EPHB4、INSM2、NFIB、RAB3B、SYT1、ZNF551、CAPN7、EPHB6、INSR、NFIC、RAB3C、SYT10、ZNF552、CAPN8、EPHX1、INSRR、NFIL3、RAB3D、SYT11、ZNF554、CAPN9、EPHX2、INTS1、NFIX、RAB3GAP1、SYT12、ZNF555、CAPNS1、EPHX3、INTS10、NFKB1、RAB3GAP2、SYT13、ZNF556、CAPNS2、EPHX4、INTS12、NFKB2、RAB3IL1、SYT14、ZNF557、CAPRIN1、EPM2A、INTS2、NFKBIA、RAB3IP、SYT15、ZNF558、CAPRIN2、EPM2AIP1、INTS3、NFKBIB、RAB40A、SYT16、ZNF559、CAPS、EPN1、INTS4、NFKBID、RAB40AL、SYT17、ZNF559-ZNF177、CAPS2、EPN2、INTS5、NFKBIE、RAB40B、SYT2、ZNF560、CAPSL、EPN3、INTS6、NFKBIL1、RAB40C、SYT3、ZNF561、CAPZA1、EPO、INTS7、NFKBIZ、RAB41、SYT4、ZNF562、CAPZA2、EPOR、INTS8、NFRKB、RAB42、SYT5、ZNF563、CAPZA3、EPPIN、INTS9、NFS1、RAB43、SYT6、ZNF564、CAPZB、EPPIN-WFDC6、INTU、NFU1、RAB44、SYT7、ZNF565、CARD10、EPPK1、INVS、NFX1、RAB4A、SYT8、ZNF566、CARD11、EPRS、IP6K1、NFXL1、RAB4B、SYT9、ZNF567、CARD14、EPS15、IP6K2、NFYA、RAB5A、SYTL1、ZNF568、CARD16、EPS15L1、IP6K3、NFYB、RAB5B、SYTL2、ZNF569、CARD17、EPS8、IPCEF1、NFYC、RAB5C、SYTL3、ZNF57、CARD18、EPS8L1、IPMK、NGB、RAB6A、SYTL4、ZNF570、CARD6、EPS8L2、IPO11、NGDN、RAB6B、SYTL5、ZNF571、CARD8、EPS8L3、IPO13、NGEF、RAB6C、SYVN1、ZNF572、CARD9、EPSTI1、IPO4、NGF、RAB7A、SZT2、ZNF573、CARF、EPT1、IPO5、NGFR、RAB7L1、T、ZNF574、CARHSP1、EPX、IPO7、NGFRAP1、RAB8A、TAAR1、ZNF575、CARKD、EPYC、IPO8、NGLY1、RAB8B、TAAR2、ZNF576、CARM1、EQTN、IPO9、NGRN、RAB9A、TAAR5、ZNF577、CARNS1、ERAL1、IPP、NHEJ1、RAB9B、TAAR6、ZNF578、CARS、ERAP1、IPPK、NHLH1、RABAC1、TAAR8、ZNF579、CARS2、ERAP2、IQCA1、NHLH2、RABEP1、TAAR9、ZNF580、CARTPT、ERAS、IQCB1、NHLRC1、RABEP2、TAB1、ZNF581、CASC1、ERBB2、IQCC、NHLRC2、RABEPK、TAB2、ZNF582、CASC10、ERBB2IP、IQCD、NHLRC3、RABGAP1、TAB3、ZNF583、CASC3、ERBB3、IQCE、NHLRC4、RABGAP1L、TAC1、ZNF584、CASC4、ERBB4、IQCF1、NHP2、
	RABGEF1、TAC3、ZNF585A、CASC5、ERC1、IQCF2、NHP2L1、RABGGTA、TAC4、ZNF585B、CASD1、ERC2、IQCF3、NHS、RABGGTB、TACC1、ZNF586、CASK、ERCC1、IQCF5、NHSL1、RABIF、TACC2、ZNF587、CASKIN1、ERCC2、IQCF6、NHSL2、RABL2A、TACC3、ZNF587B、CASKIN2、ERCC3、IQCG、NICN1、RABL2B、TACO1、ZNF589、CASP1、ERCC4、IQCH、NID1、RABL3、TACR1、ZNF592、CASP10、ERCC5、IQCJ、NID2、RABL5、TACR2、ZNF593、CASP12、ERCC6、IQCJ-SCHIP1、NIF3L1、RABL6、TACR3、ZNF594、CASP14、ERCC6L、IQCK、NIFK、RAC1、TACSTD2、ZNF595、CASP16、ERCC6L2、IQGAP1、NIM1、RAC2、TADA1、ZNF596、CASP2、ERCC6-PGBD3、IQGAP2、NIN、RAC3、TADA2A、ZNF597、CASP3、ERCC8、IQGAP3、NINJ1、RACGAP1、TADA2B、ZNF598、CASP4、EREG、IQSEC1、NINJ2、RAD1、TADA3、ZNF599、CASP5、ERF、IQSEC2、NINL、RAD17、TAF1、ZNF600、CASP6、ERG、IQSEC3、NIP7、RAD18、TAF10、ZNF605、CASP7、ERGIC1、IQUB、NIPA1、RAD21、TAF11、ZNF606、CASP8、ERGIC2、IRAK1、NIPA2、RAD21L1、TAF12、ZNF607、CASP8AP2、ERGIC3、IRAK1BP1、NIPAL1、RAD23A、TAF13、ZNF608、CASP9、ERH、IRAK2、NIPAL2、RAD23B、TAF15、ZNF609、CASQ1、ERI1、IRAK3、NIPAL3、RAD50、TAF1A、ZNF610、CASQ2、ERI2、IRAK4、NIPAL4、RAD51、TAF1B、ZNF611、CASR、ERI3、IREB2、NIPBL、RAD51AP1、TAF1C、ZNF613、CASS4、ERICH1、IRF1、NIPSNAP1、RAD51AP2、TAF1D、ZNF614、CAST、ERICH2、IRF2、NIPSNAP3A、RAD51B、TAF1L、ZNF615、CASZ1、ERLEC1、IRF2BP1、NIPSNAP3B、RAD51C、TAF2、ZNF616、CAT、ERLIN1、IRF2BP2、NISCH、RAD51D、TAF3、ZNF618、CATSPER1、ERLIN2、IRF2BPL、NIT1、RAD52、TAF4、ZNF619、CATSPER2、ERMAP、IRF3、NIT2、RAD54B、TAF4B、ZNF620、CATSPER3、ERMARD、IRF4、NKAIN1、RAD54L、TAF5、ZNF621、CATSPER4、ERMN、IRF5、NKAIN2、RAD54L2、TAF5L、ZNF622、CATSPERB、ERMP1、IRF6、NKAIN3、RAD9A、TAF6、ZNF623、CATSPERD、ERN1、IRF7、NKAIN4、RAD9B、TAF6L、ZNF624、CATSPERG、ERN2、IRF8、NKAP、RADIL、TAF7、ZNF625、CAV1、ERO1L、IRF9、NKAPL、RAE1、TAF7L、ZNF626、CAV2、ERO1LB、IRG1、NKD1、RAET1E、TAF8、ZNF627、CAV3、ERP27、IRGC、NKD2、RAET1G、TAF9、ZNF628、CBFA2T2、ERP29、IRGM、NKG7、RAET1L、TAF9B、ZNF629、CBFA2T3、ERP44、IRGQ、NKIRAS1、RAF1、TAGAP、ZNF630、CBFB、ERRFI1、IRS1、NKIRAS2、RAG1、TAGLN、ZNF638、CBL、ERVFRD-1、IRS2、NKPD1、RAG2、TAGLN2、ZNF639、CBLB、ERVMER34-1、IRS4、NKRF、RAI1、TAGLN3、ZNF641、CBLC、ERVV-1、IRX1、NKTR、RAI14、TAL1、ZNF644、CBLL1、ERVV-2、IRX2、NKX1-2、RAI2、TAL2、ZNF645、CBLN1、ESAM、IRX3、NKX2-1、RALA、TALDO1、ZNF646、CBLN2、ESCO1、IRX4、NKX2-2、RALB、TAMM41、ZNF648、CBLN3、ESCO2、IRX5、NKX2-3、RALBP1、TANC1、ZNF649、CBLN4、ESD、IRX6、NKX2-4、RALGAPA1、TANC2、ZNF652、CBR1、ESF1、ISCA1、NKX2-5、RALGAPA2、TANGO2、ZNF653、CBR3、ESM1、ISCA2、NKX2-6、RALGAPB、TANGO6、ZNF654、CBR4、ESPL1、ISCU、NKX2-8、RALGDS、TANK、ZNF655、CBS、ESPN、ISG15、NKX3- 1、RALGPS1、TAOK1、ZNF658、CBWD1、ESPNL、ISG20、NKX3-2、RALGPS2、TAOK2、ZNF660、CBWD2、ESR1、ISG20L2、NKX6-1、RALY、TAOK3、ZNF662、CBWD3、ESR2、ISL1、NKX6-2、RALYL、TAP1、ZNF664、CBWD5、ESRP1、ISL2、NKX6-3、RAMP1、TAP2、ZNF664-FAM101A、CBWD6、ESRP2、ISLR、NLE1、RAMP2、TAPBP、ZNF665、CBWD7、ESRRA、ISLR2、NLGN1、RAMP3、TAPBPL、ZNF667、CBX1、ESRRB、
ISM1、NLGN2、RAN、TAPT1、ZNF668、CBX2、ESRRG、ISM2、NLGN3、RANBP1、TARBP1、ZNF669、CBX3、ESX1、ISOC1、NLGN4X、RANBP10、TARBP2、ZNF670、CBX4、ESYT1、ISOC2、NLGN4Y、RANBP17、TARDBP、ZNF671、CBX5、ESYT2、ISPD、NLK、RANBP2、TARM1、ZNF672、CBX6、ESYT3、IST1、NLN、RANBP3、TARP、ZNF674、CBX7、ETAA1、ISX、NLRC3、RANBP3L、TARS、ZNF675、CBX8、ETF1、ISY1、NLRC4、RANBP6、TARS2、ZNF676、CBY1、ETFA、ISY1-RAB43、NLRC5、RANBP9、TARSL2、ZNF677、CBY3、ETFB、ISYNA1、NLRP1、RANGAP1、TAS1R1、ZNF678、CC2D1A、ETFDH、ITCH、NLRP10、RANGRF、TAS1R2、ZNF679、CC2D1B、ETHE1、ITFG1、NLRP11、RAP1A、TAS1R3、ZNF680、CC2D2A、ETNK1、ITFG2、NLRP12、RAP1B、TAS2R1、ZNF681、CC2D2B、ETNK2、ITFG3、NLRP13、RAP1GAP、TAS2R10、ZNF682、CCAR1、ETNPPL、ITGA1、NLRP14、RAP1GAP2、TAS2R13、ZNF683、CCAR2、ETS1、ITGA10、NLRP2、RAP1GDS1、TAS2R14、ZNF684、CCBE1、ETS2、ITGA11、NLRP3、RAP2A、TAS2R16、ZNF687、CCBL1、ETV1、ITGA2、NLRP4、RAP2B、TAS2R19、ZNF688、CCBL2、ETV2、ITGA2B、NLRP5、RAP2C、TAS2R20、ZNF689、CCDC101、ETV3、ITGA3、NLRP6、RAPGEF1、TAS2R3、ZNF69、CCDC102A、ETV3L、ITGA4、NLRP7、RAPGEF2、TAS2R30、ZNF691、CCDC102B、ETV4、ITGA5、NLRP8、RAPGEF3、TAS2R31、ZNF692、CCDC103、ETV5、ITGA6、NLRP9、RAPGEF4、TAS2R38、ZNF695、CCDC104、ETV6、ITGA7、NLRX1、RAPGEF5、TAS2R39、ZNF696、CCDC105、ETV7、ITGA8、NMB、RAPGEF6、TAS2R4、ZNF697、CCDC106、EVA1A、ITGA9、NMBR、RAPGEFL1、TAS2R40、ZNF699、CCDC107、EVA1B、ITGAD、NMD3、RAPH1、TAS2R41、ZNF7、CCDC108、EVA1C、ITGAE、NME1、RAPSN、TAS2R42、ZNF70、CCDC109B、EVC、ITGAL、NME1-NME2、RARA、TAS2R43、ZNF700、CCDC11、EVC2、ITGAM、NME2、RARB、TAS2R46、ZNF701、CCDC110、EVI2A、ITGAV、NME3、RARG、TAS2R5、ZNF703、CCDC112、EVI2B、ITGAX、NME4、RARRES1、TAS2R50、ZNF704、CCDC113、EVI5、ITGB1、NME5、RARRES2、TAS2R60、ZNF705A、CCDC114、EVI5L、ITGB1BP1、NME6、RARRES3、TAS2R7、ZNF705B、CCDC115、EVL、ITGB1BP2、NME7、RARS、TAS2R8、ZNF705D、CCDC116、EVPL、ITGB2、NME8、RARS2、TAS2R9、ZNF705E、CCDC117、EVPLL、ITGB3、NME9、RASA1、TASP1、ZNF705G、CCDC12、EVX1、ITGB3BP、NMI、RASA2、TAT、ZNF706、CCDC120、EVX2、ITGB4、NMNAT1、RASA3、TATDN1、ZNF707、CCDC121、EWSR1、ITGB5、NMNAT2、RASA4、TATDN2、ZNF708、CCDC122、EXD1、ITGB6、NMNAT3、RASA4B、TATDN3、ZNF709、CCDC124、EXD2、ITGB7、NMRAL1、RASAL1、TAX1BP1、ZNF71、CCDC125、EXD3、ITGB8、NMRK1、RASAL2、TAX1BP3、ZNF710、CCDC126、EXO1、ITGBL1、NMRK2、RASAL3、TAZ、ZNF711、CCDC127、EXO5、ITIH1、NMS、RASD1、TBATA、ZNF713、CCDC129、EXOC1、ITIH2、NMT1、RASD2、TBC1D1、ZNF714、CCDC13、EXOC2、ITIH3、NMT2、RASEF、TBC1D10A、ZNF716、CCDC130、EXOC3、ITIH4、NMU、RASGEF1A、TBC1D10B、ZNF717、CCDC132、EXOC3L1、ITIH5、NMUR1、RASGEF1B、TBC1D10C、ZNF718、CCDC134、EXOC3L2、ITIH6、NMUR2、RASGEF1C、TBC1D12、ZNF720、CCDC135、EXOC3L4、ITK、NNAT、RASGRF1、TBC1D13、ZNF721、CCDC136、EXOC4、ITLN1、NNMT、RASGRF2、TBC1D14、ZNF726、CCDC137、EXOC5、ITLN2、NNT、RASGRP1、TBC1D15、ZNF727、CCDC138、EXOC6、ITM2A、NOA1、RASGRP2、TBC1D16、ZNF728、CCDC14、EXOC6B、ITM2B、NOB1、RASGRP3、TBC1D17、ZNF729、CCDC140、EXOC7、ITM2C、NOBOX、
	RASGRP4、TBC1D19、ZNF730、CCDC141、EXOC8、ITPA、NOC2L、RASIP1、TBC1D2、ZNF732、CCDC142、EXOG、ITPK1、NOC3L、RASL10A、TBC1D20、ZNF735、CCDC144A、EXOSC1、ITPKA、NOC4L、RASL10B、TBC1D21、ZNF736、CCDC144NL、EXOSC10、ITPKB、NOD1、RASL11A、TBC1D22A、ZNF737、CCDC146、EXOSC2、ITPKC、NOD2、RASL11B、TBC1D22B、ZNF74、CCDC147、EXOSC3、ITPR1、NODAL、RASL12、TBC1D23、ZNF740、CCDC148、EXOSC4、ITPR2、NOG、RASSF1、TBC1D24、ZNF746、CCDC149、EXOSC5、ITPR3、NOL10、RASSF10、TBC1D25、ZNF747、CCDC15、EXOSC6、ITPRIP、NOL11、RASSF2、TBC1D26、ZNF749、CCDC150、EXOSC7、ITPRIPL1、NOL12、RASSF3、TBC1D27、ZNF750、CCDC151、EXOSC8、ITPRIPL2、NOL3、RASSF4、TBC1D28、ZNF75A、CCDC152、EXOSC9、ITSN1、NOL4、RASSF5、TBC1D29、ZNF75D、CCDC153、EXPH5、ITSN2、NOL6、RASSF6、TBC1D2B、ZNF76、CCDC154、EXT1、IVD、NOL7、RASSF7、TBC1D3、ZNF761、CCDC155、EXT2、IVL、NOL8、RASSF8、TBC1D30、ZNF763、CCDC157、EXTL1、IVNS1ABP、NOL9、RASSF9、TBC1D31、ZNF764、CCDC158、EXTL2、IWS1、NOLC1、RAVER1、TBC1D32、ZNF765、CCDC159、EXTL3、IYD、NOM1、RAVER2、TBC1D3B、ZNF766、CCDC160、EYA1、IZUMO1、NOMO1、RAX、TBC1D3C、ZNF768、CCDC166、EYA2、IZUMO2、NOMO2、RAX2、TBC1D3F、ZNF77、CCDC167、EYA3、IZUMO3、NOMO3、RB1、TBC1D3G、ZNF770、CCDC168、EYA4、IZUMO4、NONO、RB1CC1、TBC1D3H、ZNF771、CCDC169、EYS、JADE1、NOP10、RBAK、TBC1D4、ZNF772、CCDC169-SOHLH2、EZH1、JADE2、NOP14、RBAK-RBAKDN、TBC1D5、ZNF773、CCDC17、EZH2、JADE3、NOP16、RBBP4、TBC1D7、ZNF774、CCDC170、EZR、JAG1、NOP2、RBBP5、TBC1D8、ZNF775、CCDC171、F10、JAG2、NOP56、RBBP6、TBC1D8B、ZNF776、CCDC172、F11、JAGN1、NOP58、RBBP7、TBC1D9、ZNF777、CCDC173、F11R、JAK1、NOP9、RBBP8、TBC1D9B、ZNF778、CCDC174、F12、JAK2、NOS1、RBBP8NL、TBCA、ZNF780A、CCDC175、F13A1、JAK3、NOS1AP、RBBP9、TBCB、ZNF780B、CCDC176、F13B、JAKMIP1、NOS2、RBCK1、TBCC、ZNF781、CCDC177、F2、JAKMIP2、NOS3、RBFA、TBCCD1、ZNF782、CCDC178、F2R、JAKMIP3、NOSIP、RBFOX1、TBCD、ZNF783、CCDC179、F2RL1、JAM2、NOSTRIN、RBFOX2、TBCE、ZNF784、CCDC18、F2RL2、JAM3、NOTCH1、RBFOX3、TBCEL、ZNF785、CCDC180、F2RL3、JARID2、NOTCH2、RBKS、TBCK、ZNF786、CCDC181、F3、JAZF1、NOTCH2NL、RBL1、TBK1、ZNF787、CCDC19、F5、JDP2、NOTCH3、RBL2、TBKBP1、ZNF789、CCDC22、F7、JHDM1D、NOTCH4、RBM10、TBL1X、ZNF79、CCDC23、F8、JKAMP、NOTO、RBM11、TBL1XR1、ZNF790、CCDC24、F8A1、JMJD1C、NOTUM、RBM12、TBL1Y、ZNF791、CCDC25、F8A2、JMJD4、NOV、RBM12B、TBL2、ZNF792、CCDC27、F8A3、JMJD6、NOVA1、RBM14、TBL3、ZNF793、CCDC28A、F9、JMJD7、NOVA2、RBM14-RBM4、TBP、ZNF799、CCDC28B、FA2H、JMJD7-PLA2G4B、NOX1、RBM15、TBPL1、ZNF8、CCDC3、FAAH、JMJD8、NOX3、RBM15B、TBPL2、ZNF80、CCDC30、FAAH2、JMY、NOX4、RBM17、TBR1、ZNF800、CCDC33、FABP1、JOSD1、NOX5、RBM18、TBRG1、ZNF804A、CCDC34、FABP12、JOSD2、NOXA1、RBM19、TBRG4、ZNF804B、CCDC36、FABP2、JPH1、NOXO1、RBM20、TBX1、ZNF805、CCDC37、FABP3、JPH2、NOXRED1、RBM22、TBX10、ZNF806、CCDC38、FABP4、JPH3、NPAP1、RBM23、TBX15、ZNF808、CCDC39、FABP5、JPH4、NPAS1、RBM24、TBX18、ZNF81、CCDC40、FABP6、JRK、NPAS2、RBM25、TBX19、ZNF812、CCDC41、FABP7、JRKL、
NPAS3、RBM26、TBX2、ZNF813、CCDC42、FABP9、JSRP1、NPAS4、RBM27、TBX20、ZNF814、CCDC42B、FADD、JTB、NPAT、RBM28、TBX21、ZNF816、CCDC43、FADS1、JUN、NPB、RBM3、TBX22、ZNF816-ZNF321P、CCDC47、FADS2、JUNB、NPBWR1、RBM33、TBX3、ZNF821、CCDC50、FADS3、JUND、NPBWR2、RBM34、TBX4、ZNF823、CCDC51、FADS6、JUP、NPC1、RBM38、TBX5、ZNF827、CCDC53、FAF1、KAAG1、NPC1L1、RBM39、TBX6、ZNF829、CCDC54、FAF2、KAL1、NPC2、RBM4、TBXA2R、ZNF83、CCDC57、FAH、KALRN、NPDC1、RBM41、TBXAS1、ZNF830、CCDC58、FAHD1、KANK1、NPEPL1、RBM42、TC2N、ZNF831、CCDC59、FAHD2A、KANK2、NPEPPS、RBM43、TCAIM、ZNF835、CCDC6、FAHD2B、KANK3、NPFF、RBM46、TCAP、ZNF836、CCDC60、FAIM、KANK4、NPFFR1、RBM47、TCEA1、ZNF837、CCDC61、FAIM2、KANSL1、NPFFR2、RBM48、TCEA2、ZNF839、CCDC62、FAIM3、KANSL1L、NPHP1、RBM4B、TCEA3、ZNF84、CCDC63、FAM101A、KANSL2、NPHP3、RBM5、TCEAL1、ZNF841、CCDC64、FAM101B、KANSL3、NPHP4、RBM6、TCEAL2、ZNF843、CCDC64B、FAM102A、KARS、NPHS1、RBM7、TCEAL3、ZNF844、CCDC65、FAM102B、KAT2A、NPHS2、RBM8A、TCEAL4、ZNF845、CCDC66、FAM103A1、KAT2B、NPIPA1、RBMS1、TCEAL5、ZNF846、CCDC67、FAM104A、KAT5、NPIPA2、RBMS2、TCEAL6、ZNF85、CCDC68、FAM104B、KAT6A、NPIPA3、RBMS3、TCEAL7、ZNF850、CCDC69、FAM105A、KAT6B、NPIPA5、RBMX、TCEAL8、ZNF852、CCDC7、FAM105B、KAT7、NPIPA7、RBMX2、TCEANC、ZNF853、CCDC70、FAM107A、KAT8、NPIPA8、RBMXL1、TCEANC2、ZNF860、CCDC71、FAM107B、KATNA1、NPIPB11、RBMXL2、TCEB1、ZNF862、CCDC71L、FAM109A、KATNAL1、NPIPB15、RBMXL3、TCEB2、ZNF865、CCDC73、FAM109B、KATNAL2、NPIPB3、RBMY1A1、TCEB3、ZNF878、CCDC74A、FAM110A、KATNB1、NPIPB4、RBMY1B、TCEB3B、ZNF879、CCDC74B、FAM110B、KATNBL1、NPIPB5、RBMY1D、TCEB3C、ZNF880、CCDC77、FAM110C、KAZALD1、NPIPB6、RBMY1E、TCEB3CL、ZNF883、CCDC78、FAM110D、KAZN、NPIPB8、RBMY1F、TCEB3CL2、ZNF888、CCDC79、FAM111A、KBTBD11、NPIPB9、RBMY1J、TCERG1、ZNF891、CCDC8、FAM111B、KBTBD12、NPL、RBP1、TCERG1L、ZNF90、CCDC80、FAM114A1、KBTBD13、NPLOC4、RBP2、TCF12、ZNF91、CCDC81、FAM114A2、KBTBD2、NPM1、RBP3、TCF15、ZNF92、CCDC82、FAM115A、KBTBD3、NPM2、RBP4、TCF19、ZNF93、CCDC83、FAM115C、KBTBD4、NPM3、RBP5、TCF20、ZNF98、CCDC84、FAM117A、KBTBD6、NPNT、RBP7、TCF21、ZNF99、CCDC85A、FAM117B、KBTBD7、NPPA、RBPJ、TCF23、ZNFX1、CCDC85B、FAM118A、KBTBD8、NPPB、RBPJL、TCF24、ZNHIT1、CCDC85C、FAM118B、KCMF1、NPPC、RBPMS、TCF25、ZNHIT2、CCDC86、FAM120A、KCNA1、NPR1、RBPMS2、TCF3、ZNHIT3、CCDC87、FAM120AOS、KCNA10、NPR2、RBX1、TCF4、ZNHIT6、CCDC88A、FAM120B、KCNA2、NPR3、RC3H1、TCF7、ZNRD1、CCDC88B、FAM120C、KCNA3、NPRL2、RC3H2、TCF7L1、ZNRF1、CCDC88C、FAM122A、KCNA4、NPRL3、RCAN1、TCF7L2、ZNRF2、CCDC89、FAM122B、KCNA5、NPS、RCAN2、TCFL5、ZNRF3、CCDC9、FAM122C、KCNA6、NPSR1、RCAN3、TCHH、ZNRF4、CCDC90B、FAM124A、KCNA7、NPTN、RCBTB1、TCHHL1、ZP1、CCDC91、FAM124B、KCNAB1、NPTX1、RCBTB2、TCHP、ZP2、CCDC92、FAM126A、KCNAB2、NPTX2、RCC1、TCIRG1、ZP3、CCDC93、FAM126B、KCNAB3、NPTXR、RCC2、TCL1A、ZP4、CCDC94、FAM127A、KCNB1、NPVF、RCCD1、TCL1B、ZPBP、CCDC96、FAM127B、KCNB2、NPW、RCE1、TCN1、ZPBP2、
	CCDC97、FAM127C、KCNC1、NPY、RCHY1、TCN2、ZPLD1、CCER1、FAM129A、KCNC2、NPY1R、RCL1、TCOF1、ZRANB1、CCHCR1、FAM129B、KCNC3、NPY2R、RCN1、TCP1、ZRANB2、CCIN、FAM129C、KCNC4、NPY4R、RCN2、TCP10、ZRANB3、CCK、FAM131A、KCND1、NPY5R、RCN3、TCP10L、ZRSR2、CCKAR、FAM131B、KCND2、NQO1、RCOR1、TCP10L2、ZSCAN1、CCKBR、FAM131C、KCND3、NQO2、RCOR2、TCP11、ZSCAN10、CCL1、FAM132A、KCNE1、NR0B1、RCOR3、TCP11L1、ZSCAN12、CCL11、FAM132B、KCNE1L、NR0B2、RCSD1、TCP11L2、ZSCAN16、CCL13、FAM133A、KCNE2、NR1D1、RCVRN、TCP11X1、ZSCAN18、CCL14、FAM133B、KCNE3、NR1D2、RD3、TCP11X2、ZSCAN2、CCL15、FAM134A、KCNE4、NR1H2、RD3L、TCTA、ZSCAN20、CCL16、FAM134B、KCNF1、NR1H3、RDH10、TCTE1、ZSCAN21、CCL17、FAM134C、KCNG1、NR1H4、RDH11、TCTE3、ZSCAN22、CCL18、FAM135A、KCNG2、NR1I2、RDH12、TCTEX1D1、ZSCAN23、CCL19、FAM135B、KCNG3、NR1I3、RDH13、TCTEX1D2、ZSCAN25、CCL2、FAM136A、KCNG4、NR2C1、RDH14、TCTEX1D4、ZSCAN26、CCL20、FAM13A、KCNH1、NR2C2、RDH16、TCTN1、ZSCAN29、CCL21、FAM13B、KCNH2、NR2C2AP、RDH5、TCTN2、ZSCAN30、CCL22、FAM13C、KCNH3、NR2E1、RDH8、TCTN3、ZSCAN31、CCL23、FAM149A、KCNH4、NR2E3、RDM1、TDG、ZSCAN32、CCL24、FAM149B1、KCNH5、NR2F1、RDX、TDGF1、ZSCAN4、CCL25、FAM150A、KCNH6、NR2F2、REC8、TDO2、ZSCAN5A、CCL26、FAM150B、KCNH7、NR2F6、RECK、TDP1、ZSCAN5B、CCL27、FAM151A、KCNH8、NR3C1、RECQL、TDP2、ZSCAN9、CCL28、FAM151B、KCNIP1、NR3C2、RECQL4、TDRD1、ZSWIM1、CCL3、FAM153A、KCNIP2、NR4A1、RECQL5、TDRD10、ZSWIM2、CCL3L1、FAM153B、KCNIP3、NR4A2、REEP1、TDRD12、ZSWIM3、CCL3L3、FAM154A、KCNIP4、NR4A3、REEP2、TDRD3、ZSWIM4、CCL4、FAM154B、KCNJ1、NR5A1、REEP3、TDRD5、ZSWIM5、CCL4L1、FAM155A、KCNJ10、NR5A2、REEP4、TDRD6、ZSWIM6、CCL4L2、FAM155B、KCNJ11、NR6A1、REEP5、TDRD7、ZSWIM7、CCL5、FAM156A、KCNJ12、NRAP、REEP6、TDRD9、ZSWIM8、CCL7、FAM156B、KCNJ13、NRARP、REG1A、TDRKH、ZUFSP、CCL8、FAM157A、KCNJ14、NRAS、REG1B、TDRP、ZW10、CCM2、FAM157B、KCNJ15、NRBF2、REG3A、TEAD1、ZWILCH、CCM2L、FAM159A、KCNJ16、NRBP1、REG3G、TEAD2、ZWINT、CCNA1、FAM159B、KCNJ18、NRBP2、REG4、TEAD3、ZXDA、CCNA2、FAM160A1、KCNJ2、NRCAM、REL、TEAD4、ZXDB、CCNB1、FAM160A2、KCNJ3、NRD1、RELA、TEC、ZXDC、CCNB1IP1、FAM160B1、KCNJ4、NRDE2、RELB、TECPR1、ZYG11A、CCNB2、FAM160B2、KCNJ5、NREP、RELL1、TECPR2、ZYG11B、CCNB3、FAM161A、KCNJ6、NRF1、RELL2、TECR、ZYX、CCNC、FAM161B、KCNJ8、NRG1、RELN、TECRL、ZZEF1、CCND1、FAM162A、KCNJ9、NRG2、RELT、TECTA、ZZZ3、CCND2、FAM162B、KCNK1、NRG、RHODOPSIN、RdCVF、RdCVFL、GIRK、DUX4、 And DBET (or DBET lncRNA).

Examples

The following examples are given for the purpose of illustrating various embodiments of the invention and are not meant to limit the invention in any way. The present examples and methods described herein presently represent preferred embodiments, are exemplary, and are not intended to limit the scope of the invention. Variations therein and other uses encompassed by the spirit of the invention as defined by the scope of the claims will occur to those skilled in the art.

Example 1 combinatorial modulator screening

The activation domains of human and viral transcriptional regulators identified in the high throughput screen were tested as single or tandem fusions targeting GFP reporter. As shown in fig. 1A, the single activator (top sub-panel) showed weak to moderate activation of GFP, while the combined modulator (bottom sub-panel) showed strong activation, independent of the orientation of the modulators. As shown in fig. 1B, the combination of modulators activated GFP to levels greater than the sum of the individual modulators, which is a marker of transcriptional synergy.

100 Putative modulators previously identified from 85aa blocks (tiles) across the human and viral proteomes were used as initial candidates. As shown in fig. 2A, a panel of 85 modulators (50 viruses, 35 humans) was selected from the candidate gene modulators for testing in a combinatorial screen along with positive and negative controls. The selected blocks represent weak, medium and strong activators identified in the initial screen (fig. 2B). As shown in FIG. 2C, homology clusters demonstrated a high degree of sequence diversity between candidate modulators and further confirmed that the library block contained multiple predicted protein domains (FIG. 2D).

As shown in fig. 3A, 100 candidate modulators were synthesized as a or B variants with unique codon usage and homology arms to facilitate targeted cloning into the grna+pyl1 lentiviral expression vector. The K562 cells harboring the unstable GFP reporter gene were engineered to stably express dCasMINI-ABI fusion (fig. 3B). Upon addition of the plant hormone abscisic acid (ABA), ABI dimerizes with PYL1, causing the regulator to be recruited to the reporter locus. As shown in FIG. 3C, recruitment and reversibility of the reporter system was verified using K562-GFP-dCasMINI-ABI cells transduced with lentiviruses encoding PYL 1-activator fusions and gRNAs targeting GFP reporter genes. Robust GFP activation was observed 24 hours after ABA treatment. After 7 days of ABA elution, GFP expression had recovered to levels comparable to DMSO controls.

Referring to FIG. 4, K562-GFP reporter cells expressing dCasMINI-ABI were transduced with a PYL1-ComboMod fusion library and treated with DMSO or ABA. GFPON cells were sorted by FACS into 4 discrete bins representing the quartiles of GFP expression. Genomic DNA was harvested and libraries were prepared from 4 GFPON intervals and GFPOFF intervals in 4 replicate samples. The modulator combinations in each interval were identified by double-ended sequencing and enrichment in the GFPON vs GFPOFF interval was determined using DESEQ.

As shown in fig. 5A, DESEQ2 analysis of ComboMod enrichments identified 1393 hits with FDR < 0.05. As shown in fig. 5B, most of the strong activators consisted of 1 or more viral activators (left side), and some human-human combinations were also identified as strong activators (right side). The heat map indicating the activation states of all 100×100 combination modulators shows that strong activation combinations tend to cluster along a row or column, highlighting the predictability of a few modulators in driving strong combinations (fig. 5C).

As shown in fig. 6, the biochemical and biophysical characteristics of the combination modulator were evaluated. The strong activation combination enriches the negative electrostatic potential (fig. 6A), and generally requires a beta factor (a measure of structural flexibility) of one of the partners between 35-60 (fig. 6B).

The selection of 100×100 human and virus-derived modulators demonstrates the relative strength of the activation domains between virus and human groups using a high throughput screening platform for combinations of transcriptional modulators. In some cases, the person-to-person combination is superior to its individual composition regulator. These strong combinatorial activation domains may prove useful in therapeutic settings where immunogenicity is a concern. Furthermore, combinations of weak or moderate activators may prove beneficial in achieving adjustable levels of activation. In some cases, combo Mod hits can modulate endogenous target genes in various cell types.

Example 2 synthetic reporter cell line validation screening

The regulatory effect of the combination modulator identified in example 1 was re-analyzed using synthetic reporter cell line validation screening. Synthetic reporter cells include GFP reporter gene sites and are engineered to express engineered gene effectors. To evaluate the modulation of the combination modulator, the expression of the non-expressed GFP reporter gene at baseline was determined as fold change (log 2 fold change). The results are provided in table 9. The fold change values for each of the combination modulators are contained in the log2 fold change column of table 9. In this screen, cells expressing the combination modulator were sorted into 5 discrete intervals representing the quartiles of gfp_off and gfp_on intensities. Each of these intervals has a specific GFP average fluorescence intensity value. During the analysis, the MFI value of each combination regulator is calculated by weighted summation of the average fluorescence intensities (MFI) over all intervals, e.g. if combo_75 has 90 reads in the OFF interval and 10 counts in the highest GFP interval, the MFI of combo_75 will be (0.9 x gfp_value_off) + (0) + (0) + (0) + (0.1 x gfp_value_highest_on). The MFI value in the bottom quartile is labeled as "weak" activator, the two middle quartiles are labeled as "medium" activator, and the top quartile is labeled as "strong" activator. These categories are shown in the "mfi_status" column of table 9.

Example 3 endogenous Gene verification screening

Modulation of the combination modulator identified in example 1 was analyzed using endogenous gene verification screening. HEK293T cells were engineered to express an engineered gene effector targeting endogenous CD45 genes. To evaluate the modulation of engineered gene effectors, CD45 gene expression was determined as fold change (log 2 FC) at three time points (day 2, day 8 and day 14) after transfection, the CD45 gene not being expressed at baseline. The results are provided in table 10. Fold change values for each engineered gene effector are included in the "day 2_log2fc", "day 8_log2fc", and "day 14_ logFC" columns of table 10. In table 10, the a_peptide and b_peptide sequences beginning with "×" represent the N-terminal stop codons that prevent translation of the remainder of the listed sequences encoded by the nucleic acid and serve as internal controls. The persistence of the modulation of the engineered gene effector was assessed based on fold change values on day 8 and day 14.

Example 4 comparison of engineered Gene effectors-activation of epigenetic resting loci

HEK293 cells were transfected to express engineered gene effectors targeting endogenous CD45 genes (epigenetic resting sites). Some of the engineered gene effectors detected comprise a first peptide and a second peptide. Some of the engineered gene effectors detected are encoded by functional biological sequences generated using computer-implemented methods. To assess the persistence of the modulation of engineered gene effectors, the expression of CD45 gene, which was not expressed at baseline, was assayed at day 9 as fold change values (fig. 7A-7B).

Example 5 comparison of engineered Gene effectors-reactivation of epigenetic silencing sites

HEK293 cells were transfected to express engineered gene effectors targeting epigenetic silencing sites, including GFP reporter gene sites. To evaluate the modulation of engineered gene effectors, the percentage of transfected cells expressing GFP (gfp+) was calculated on days 2 and 6 (fig. 8).

Example 6 Generation of functional biological sequences Using evolved Monte Carlo

In this embodiment, evolved monte carlo is a statistical sampling method/means for finding new functional biological sequences. As depicted in fig. 9A-9D, a list of random/predefined sequences is provided, iteratively randomly mutating in a computer, and evaluating based on a machine learning model at each iteration. Every few iterations, the sequence list is "shuffled" or "crossed" in an attempt to significantly increase the search space, and then evaluated again on the computer. If the algorithm encounters new sequences with high evaluation in the computer machine learning model, these sequences are stored (e.g., added to a list) and then tested at the wet laboratory level. Machine learning algorithms predict which sequences are functionally biologically active.

Using the above method, 4.6K new sequences predicted to have functional biological activity were generated. Each of these new sequences is then compared to each sequence in the training dataset and their associated edit distance calculated. Edit distance is a measure for determining the degree of similarity or dissimilarity between two sequences, a high edit distance means that two sequences are very dissimilar to each other. The minimum edit distance for each of the 4.6k new sequences was plotted onto the sequences in the original training dataset (fig. 10) and it was confirmed that these new sequences were significantly different from the training dataset (over 55 mismatches on average over a list of 85 sequences), indicating that the machine-learning generated sequences were indeed new and were not merely a reorganization of positive hits in the training dataset. FIG. 11 is a representation of a sequence generated in two dimensions, where it is shown that the new sequence occupies a different space in the 2D view.

Example 7-1 improved Small sample learning-based protein engineering

Design of new protein sequences remains a slow and expensive process due to various protein engineering challenges, and in particular, the number of protein variants that can be experimentally tested in a given experiment is dwarfed compared to the broad overall sequence space, resulting in low hit rates and expensive wet laboratory test cycles. In this example, a small sample learning method of new protein design is described, aimed at speeding up the expensive wet laboratory test cycle, and enabling the use of a small, skewed training dataset (about 10 ⁵ data points, <1% positive hit). The method comprises a semi-supervised transfer learning method and a new evolutionary Monte Carlo Markov chain sampling algorithm, wherein the semi-supervised transfer learning method is used for generating a discrete fitness view for a desired protein function, so that the fitness view is explored more effectively. The performance of the method is proved by experimental screening of the predicted high-fitness gene activating factor, and compared with the existing method, the hit rate is obviously improved. The present method can be readily adapted to other protein engineering and design issues, particularly where the costs associated with obtaining the labeling data are very high.

Designing and optimizing proteins with specific functions is a long-sought goal in protein engineering. Since proteins are composed of amino acid sequences that ultimately determine their structure and function, the protein engineering problem can be re-evolved to find the best mapping from the amino acid sequence s of length L to the biological function f, s.fwdarw.f(s), where f is called the fitness function. Finding the optimal solution for f can be seen as a high-dimensional discrete combination optimization problem. The large size of the protein sequence space (e.g., 20 ^L possible peptides of length L; 3.84e110 at l=85) and the presence of sensitive and sporadic regions of high fitness in the fitness landscape makes the design of novel proteins an extremely difficult problem.

Traditional methods of novel protein design involve high-throughput, iterative laboratory methods such as directed evolution, deep mutation scanning, and semi-rational design. However, these methods typically require multiple rounds of engineering and analysis, making them cumbersome, expensive, and time consuming. Furthermore, the number of variants that can be tested even in the most advanced laboratories (10 ⁵ to 10 ⁶) is very small compared to the size of the total sequence space, and high throughput screening can be challenging for certain classes of proteins.

In the last decade, the application of machine learning methods to protein engineering has met with tremendous success. In this context, a machine learning model is trained to learn a mapping of sequences to functions (also called fitness functions) and then used to propose new sequences that maximize fitness (and thus the predicted functions). Typically, this is two distinct steps, where fitness is estimated using a machine learning model, and then the sequence-to-function mapping is used to explore the fitness landscape by methods such as Metropolis-Hastings Monte Carlo Search.

In recent years, other methods (e.g., generating models) have been proposed to address this problem, including deep generation of networks, generation of antagonism networks, and diffusion models. In these cases, the exploration problem is trivial, as the model creates an embedding in real space (typically low dimensional) and the computational cost of sampling from that space is low. However, these methods typically require a large amount of training data and a large amount of positive examples to ensure that model embedding is meaningful, and do not simply remember the positive examples, which has been widely observed in image GAN. Given the relatively small number of sequences in training data, and the extreme lack of positive examples, it is expected that training data that is small and skewed will prove insufficient for generating modeling methods. On the other hand, migration learning of Large Protein Language Models (LPLM) has been successful in modeling and designing new proteins whose fitness function is trained on a small number of positive hits. While transfer learning and ML-based sequence-to-function mapping are increasingly receiving widespread attention, model-guided fitness graph exploration remains an under-studied problem in the context of protein engineering.

The Metropolis-Hastings Monte Carlo Search (MHMCS) method is a standard method for exploring high-dimensional discrete views (including those generated by machine learning algorithms), however MHMCS suffers from the inability to get rid of deep local optimal solutions. Other methods of sampling sequence space include gradient-based sampling and modified gibbs sampling. While these methods are powerful, they require extensive computation near the local neighborhood of the fitness view and are therefore computationally too extensive for any significant length sequence (e.g., gradient-based methods require 19L computations per iteration, while Gibbs requires L computations).

Evolutionary Monte Carlo (EMC) is an advanced sampling method that is sensitive to MCMC technology from genetic recombination as well as physics-based. While EMC has previously been used for various sampling tasks, its potential as an efficient algorithm to explore fitness graphs of ML generation in the context of protein engineering has not been explored. In this example, EMC was modified as a search tool for exploring complex fitness patterns of protein sequences capable of gene regulation, referred to herein as EMC Search (EMCs). While EMCS is far less computationally intensive than gradient-based and gibbs samples (and only slightly more intense than MHMCS), it is expected to benefit from faster convergence (due to parallel tempering) and provide more comprehensive and efficient fitness view exploration (by allowing interpolation at the molecular level between chains).

In general, novel protein sequence design strategies using a small sample transfer learning-based approach have been proposed. While this approach is generally applicable to a wide variety of problems, it is applied to the design of protein-based gene activators. High throughput screening of protein sequences has been previously performed to find novel gene activators and to identify less than 200 sequences that are verified to be positive hits (resulting in hit rates of about 0.5%). The small number of positive examples presents a particular problem for ML-guided engineering, as it is difficult to ensure that the fitness function will extrapolate well outward from a small neighborhood of positive examples in the training set. In this study, it was demonstrated that EMCS not only increases the sequence diversity and novelty of the designed sequences, but it also significantly increases the hit rate of the proposed sequences compared to the original high-throughput screening. Furthermore, EMCS can be initialized from known hits and still identify candidate sequences that are distinct from any original molecule, while MHMCS has difficulty getting rid of the locally optimal solution of the known hit.

High throughput screening and independent validation was previously performed in which the ability of 85aa peptide to activate synthetic gene sites was tested using dCasMini gene expression regulatory subsystem (dCasMini-GEMS). This allowed 173 gene activators ("positive hits") to be identified from the training set of 34217 protein sequences (hit rate of 0.51%). With this data, an attempt is made to train a machine learning model that can predict only from the sequences proteins that can activate the genes. Since the dataset of peptide sequences essentially consists of amino acid strings, each peptide sequence needs to be numerically characterized for use as input to a training supervised classification model. OneHot codes were compared to the transfer learning, using LPLM (ESM-2 model) of 6.5 hundred million parameters as input features for both models, XGBoost model and CNN model, XGBoost model flattened the features by averaging. In the test phase, it was found that the transfer learning significantly improved the predictions for both models, and the proposed sequence for each model appeared to capture different features of the training data. In fact, this is not surprising, since for XGBoost, the flattening of the mean of feature embedding amounts to training the global features of these peptide sequences, whereas the CNN model is able to learn the local features. Thus, both models are used with transfer learning to design molecules (fig. 12A), respectively, and with integrated models based on transfer learning to take advantage of global and local features learned by XGBoost and CNN models, respectively.

The MHMCS algorithm operates by proposing a small number of mutations to modify the current molecule and then evaluating the fitness of the new molecule, accepting the scheme if fitness increases, but accepting the scheme with a probability weighted by the ratio of the proposed fitness to the current fitness if fitness decreases. The latter possibility ensures that sub-optimal movements can be made to ensure that the search can be free of locally optimal solutions, but MHMCS tends to be difficult to handle for extremely deep optimal solutions.

The Evolutionary Monte Carlo Search (EMCS) extends the traditional Metropolis-Hastings Monte Carlo search (MHMCS) by introducing gene crossover events in the parallel tempering setup. In parallel tempering, multiple MHMCS chains run simultaneously at different temperatures (referred to as temperature gradients) and are exchanged at two randomly selected temperatures after a predetermined number of iterations. The main advantage of parallel tempering is that it allows MHMCS to occur within a larger search radius without sacrificing resolution. EMCS is based on parallel tempering by adding gene crossover events (domain exchange by chain interpolation). This allows for even larger search radii (fig. 12B) while also increasing the likelihood of favorable protein domain aggregation, which is assumed to be critical for utilizing a small number of positive hits in the training data.

Algorithm 1 below describes in detail the implementation of evolved monte carlo as a search tool. EMCS is highly versatile and allows for distinct exploration behavior compared to traditional sampling techniques due to the implementation of custom temperature gradients and predefined crossover, mutation and exchange rates. These parameters can be adjusted for more efficient exploration based on specific design issues and the complexity of the discrete high-dimensional fitness view. Each major iteration in EMCS may potentially change the state of the algorithm in one of three ways, namely point mutations, exchanges, and crossings between different temperature chains. The likelihood that each of these three classes accepts sub-optimal movement depends on how the acceptance criteria are defined. Rmh, which is the standard Boltzmann Metropolis-Hastings acceptance criterion, is used for mutation-based movements, which, as previously described, accepts suboptimal movements with the probability of being weighted by the ratio of the proposed fitness to the current fitness. For the exchange between two consecutive chains rre is used as standard parallel tempering criterion. Using this criterion, any proposed exchange in which to propose moving the higher fitness sequence to a lower temperature chain will be accepted. In the exchange where it is proposed to move a higher fitness sequence to a higher temperature, the movement is accepted with a probability inversely proportional to the magnitude of the temperature difference of the two chains and the fitness of the two sequences. Finally, the crossover criterion r _c accepts the crossover movement (taking into account both the difference in fitness of the generated new sequence set to the old sequence and the difference in temperature of the two chains involved in the crossover). Notably, in general, the crossover criterion penalizes the overall decrease in fitness when both chains are considered.

Protein fitness maps are known to be highly sensitive, multimodal, and rugged, reflecting the possibility that complete loss of function may occur due to relatively small numbers of point mutations (e.g., mutations in the catalytic domain, mutations that result in misfolding). The complexity of such space presents significant challenges for efficient exploration. Here, we compared how EMCS and MHMCS explored the discrete fitness view of the 85aa protein, respectively, that was able to activate the gene, and evaluated the prediction success rate, sequence diversity and convergence rate.

For experimental verification, EMCS and MHMCS were used to design novel proteins using all three models (XGBoost, CNN and integration). Together, EMCS and MHMCS designed 4600 new sequences, which were very different from the sequence space occupied by the original training data (fig. 13), confirming that both model-directed sampling techniques could propose different novel proteins. To ensure accurate identification of gene activators in the experimental validation, 300 previously validated negative controls (random sequences) were also included in the library. The ability of the peptide to activate the gene locus was then tested experimentally. In total 357 positive hits (hit rate 7.59%) were identified, where positive hits refer to the peptide found to be significantly above background fluorescence and activated the synthetic gene reporter. In contrast, the hit rate of the initial screening was only 0.51%. If the latter number is used as a representation of a portion of the naturally occurring 85aa peptide sequence that can act as a consensus gene activator, the designed peptide will have an increase in hit rate of about 15-fold. In fact, the best model guided sampling technique (ensemble model+emcs from known hits) increases hit rate by a factor of 45 (table 1). Even if initialized from known sequences, the proposed peptides are very different from any peptide in the training set, indicating that EMCS works very well in traversing fitness graphs and identifying high fitness peptides.

TABLE 1 Positive hit results for Integrated model

Searching method	Initialization of	Sequence #	# Positive hit	Percentage of hits
					EMCS	Is known to be	410	94	22.9%
EMCS	Random arrangement	390	39	10%
					MHMCS	Random arrangement	200	2	1%

EMCS is unique in its ability to find the optimal solution corresponding to different sequences, even starting from known positive hit sequences (and thus already high fitness sequences). It is shown herein that the final edit distance of the sequence found by EMCS is significantly higher when starting from a known positive sequence compared to the sequence found by MHMCS using similar temperature conditions. Consistently, using entropy as a measure of information change, the average entropy change for each of the EMCS and MHMCS in 10 ⁷ iterations was calculated (fig. 14A), and it was shown that the average entropy change for each iteration of EMCS (using a crossover rate of 0.5 and a default parameter for 4 total chains) was about 3 times higher than MHMCS (assuming the mutation rate is the same).

The proposed increase in sequence diversity and entropy increase per iteration observed with EMCS is inferred to be due to a genetic crossing step, in which functionally beneficial protein domains can be exchanged between known sequences, followed by further refinement by point mutation. Since the initial sequence already occupies a high fitness domain, the final sequence diversity is ensured by forcing the algorithm to run a predetermined number of iterations. The elimination of local minima is further facilitated by the introduction of a temperature gradient (which allows increasing the search radius). In contrast MHMCS is limited to a single temperature and only has access to domains in the fitness function that are accessible only by point mutations. This hampers MHMC's ability to converge to domains corresponding to different sequences when starting from a known positive sequence, as it requires many optimal movements to get rid of the locally optimal solution of the original sequence.

To assess how fast EMCS converges to a high fitness sequence relative to MHMCS, a computer simulated sampling experiment was performed in which 4000 heuristics were performed on fitness graphs with each algorithm using the same and controlled initial conditions.

When initialized with a random sequence, EMCS converges 1.25-5 times faster than MHMCS, depending on the choice of temperature and crossover rate, probably due to the increased versatility of the algorithm over MHMCS. Using default parameters, 1171 EMCS runs achieve convergence, where each run obtains at least one sequence with a fitness of 0.95 or greater. Furthermore, since 4 strands are involved, EMCS produces on average 2.322 sequences with fitness ≡0.5 per run, giving a total of n=2720 sequences with fitness ≡0.5 for 1171 runs. For MHMCS, the minimum failure rate of the chain starting at temperatures above 2.5X10 ^-2 or higher was 50% and was discarded from the experiment. When these sequences were excluded, a total of n=2571 sequences were obtained from 2571 runs. Wherein the adaptability of 2361 sequences is more than or equal to 0.95. The remaining 210 failed to converge, but still had a final fitness of 0.5 or more. Fig. 14B together shows the average number of iterations that converge.

In this embodiment, a two-step machine learning and sampling method is proposed for protein engineering problems with limited training data and sparse positive hits. The method involves estimating an adaptation map using a Large Protein Language Model (LPLM) with transfer learning, and then effectively sampling the adaptation map with an Evolved Monte Carlo Search (EMCS) to propose a novel high-adaptation protein sequence. As a proof of concept, this approach was applied to the problem of designing small gene activators and showed that this approach successfully designed new and diverse protein sequences with significantly higher validation rates as gene activators when compared to the more traditional sampling method (MHMCS) or baseline discovery of high throughput screening.

Given the complexity of the wet laboratory test cycle, the importance of this approach is amplified by single round screening involving library design, DNA synthesis, plasmid cloning, viral packaging, cell line infection, fluorescence Activated Cell Sorting (FACS), DNA library preparation, next generation DNA sequencing, and downstream bioinformatics analysis. Furthermore, in the field of rational protein engineering, multiple rounds of iterative screening are often required to discover and verify novel proteins with desired functions. In view of the financial, time and technical costs associated with wet laboratory test cycles, it would be of significant value to accelerate this process to ease the experimental burden of protein engineering. In addition to accelerating new protein designs, this approach opens up many new approaches to existing protein engineering methods (e.g., semi-rational engineering) due to the discovery of new and diverse sequences that can be used to gain a deeper understanding of the desired protein function. The vast protein sequence space, coupled with the computational cost of embedding proteins using LPLM (e.g., ESM-2), requires efficient sampling algorithms that can be freed from locally optimal solutions without losing resolution. EMC algorithms are well suited for this application scenario, as the introduction of temperature gradients allows for multiple acceptance rates to exist simultaneously. Furthermore, the genetic crossing step allows for more efficient exploration of fitness views, as shown by the sequence diversity of MHMCS VS EMCS and the average entropy change per iteration.

The strength of this approach is believed to combine LPLM-mediated transfer learning with EMCS. Since LPLM is trained on a large number of different protein sequences, modern LPLM embedding implicitly contains rich features describing the biochemical, biophysical, evolutionary and even three-dimensional information of the protein, and it is therefore reasonable to think that LPLM embedding of the newly proposed sequence is able to capture the predicted functional consequences of EMCS gene crossover, so that the exchange of inactive proteins that would lead to misfolding is designated as low-fitness and not selected by EMCS. In contrast, with this semi-supervised transfer learning-based model, potential exchanges and domains that can act synergistically will be assigned a high degree of fitness and selected by EMCS even though these domains are evolutionarily unrelated. In contrast, since GAN and diffusion models are sampled from a low dimensional subspace and then passed through the model to obtain the proposed sequence, only sequences in the subspace that are close to the training data can be designed by these methods, and furthermore, there is no guarantee that the high collaborative domains will be close in the subspace (especially if they are not evolutionarily related), which limits the potential diversity of sequences that can be proposed by the generation algorithm trained on limited and skewed training data.

This framework is believed to have many advantages over previous ML-guided protein design methods using traditional sampling techniques, as well as classical laboratory protein engineering methods. First, assays to screen peptides of specific function in diverse natural proteins typically have very low hit rates, while new sequences proposed by this approach have significantly higher hit rates in validation experiments. Furthermore, the small number of positive hits in the training data of protein engineering problems inherently limits the accuracy of fitness functions universality, and this approach is believed to alleviate these drawbacks by exploiting the information from LPLM and incorporating multiple positive hits into the proposed new sequence through EMCS domain exchange. Finally, while proof of concept involves the design of relatively small proteins, it is expected that this approach will be particularly applicable to protein engineering problems involving larger proteins having multiple characterized domains.

The methods described in this example will speed up the design and testing of novel proteins for a variety of purposes, including therapeutic drugs.

Example 7-2 fitness view exploration Using novel EMCS

This example provides additional illustration of example 7-1.

A generative AI platform was constructed that enabled de novo design of ultra-compact regulatory peptides with the ability to transcriptionally up-regulate a genetic locus. By performing high throughput screening, a large amount of training data was collected for the first time to discover novel transcriptional activators among peptides derived from the human, viral and archaeal proteomes. Machine learning ensemble models consisting of decision tree models and convolutional neural networks are trained that utilize transfer learning (embedded by large protein language models) to predict transcriptional activators based on peptide sequences alone. This machine learning platform is used to generate libraries of thousands of ultra-compact peptides predicted as transcriptional activators by using a novel sampling algorithm called the evolutionary monte carlo search to more efficiently traverse the predicted fitness graph.

Experimental screening of these peptides and verification that the generated AI method significantly improved the rate of discovery (up to 45-fold), thereby discovering hundreds of novel transcriptional activators with little sequence similarity to known naturally occurring peptides. Studies of the evolutionary, biochemical and biophysical properties of synthetic activator libraries revealed that validated activators consistently lack conserved functional domains, but do share certain biochemical features such as strong negative electrostatic potentials. The 10 top-ranked synthetic activators were then selected for further characterization and their activation intensity was assessed by screening them at the artificial GFP locus and endogenous human locus (CD 45), and their potency was compared to gold standard activators (e.g., vCD, VP 64). These results demonstrate the ability of machine learning to accelerate the discovery of novel functional peptides, expanding our epigenetic regulator toolkit for future therapeutic applications.

Gene expression regulatory System (GEMS) the gene expression and regulatory System (GEMS) consists of 1) dCasMini ¹ compact, programmable DNA binding proteins, 2) one or more guide RNAs, 3) regulatory peptides capable of activating or repressing gene expression. See Xiaoshu Xu et al, ENGINEERED MINIATURE CRISPR-CAS SYSTEM for mammalian genome regulation AND EDITING, molecular Cell, vol.81, stage 20, DOI: 10.1016/j. Molcel.2021.08.008.2021.

After the protein fitness maps were generated as described in example 7-1, the fitness maps were explored using the EMCS algorithm and functional biological sequences were generated. A schematic diagram of the EMCS algorithm components is shown in fig. 15. The EMCS algorithm comprises the following components, 1) running parallel MHMCS, 2) temperature gradient implementation (parallel tempering), and 3) domain exchange between peptide chains running parallel (EMCS). The inspiration of EMCS comes from gene exchange events to allow domain exchange to occur between parallel MHMCS runs, enabling more efficient exploration of fitness views.

Comparison of EMCS with MHMCS the entropy change and convergence time of MHMCS and EMCS iterations are measured. EMCS allows for greater sequence diversity per iteration (as measured by entropy change per iteration (fig. 16A)) and faster convergence time (fig. 16B) when compared to MHMCS. For ablation studies, PTP (parallel tempering) and EMC-NPT (EMCs without parallel tempering) were run.

Experimental verification of functional biological sequences with high predictive fitness EMCS and MHCMS were used to design 4600 new sequences that are very different from the sequence space occupied by the training dataset. The ability of the engineered gene effectors encoded by 4600 new sequences to activate synthetic gene loci was tested. Fig. 17 depicts FACS histograms from engineered gene effector validation experiments. Using standard differential expression analysis procedure (DESEQ 2), 357 out of 4600 engineered gene effectors (hit rate 7.51%) significantly activated the gene reporter compared to background fluorescence. In contrast, the hit rate of the training dataset was 0.51%. A hit rate of 20.6% was achieved using EMCS. The statistics of the differential expression analysis are shown in table 2.

TABLE 2 Positive hit results of sampling algorithm

Algorithm	Initialization of	Total sequence	Number of yang hits	Percentage of hits
					EMCS	All of which	2600	338	13%
MHMCS	All of which	2000	18	0.9%
					EMCS	Is known to be	1310	270	20.6%
EMCS	Random arrangement	1290	68	5.3%
					MHMCS	Random arrangement	2000	18	0.9%
Negative control	n/a	300	1	0.33%

Biochemical analysis of experimentally verified functional biological sequences Biochemical and structural characterization of experimentally verified functional biological sequences was studied using ESMFold (FIGS. 18A-18C). In general, functional biological sequences are rich in acidic residues that contribute to the solvent-accessible surface area, are moderately flexible (average β -factor near 45), lack β -sheet, and consist primarily of random coils and α -helices.

Verification screening of engineered gene effectors encoded using computer-implemented methods functional biological sequences 748 were analyzed for modulation of the engineered gene effectors using two verification screens. To evaluate the modulation of engineered gene effectors, the expression was measured as fold change values. The results are shown in Table 11. Fold change values for each engineered gene effector are contained in the "log2 fold change" column of table 11.

The modulation of 10 selected engineered gene effectors (SEQ ID NOs: 1495, 1592, 1595, 1634, 1654, 1665, 1677, 1686, 1689, 1716) encoded by functional biological sequences generated using computer-implemented methods was further analyzed using endogenous gene verification screening. HEK293T cells were engineered to express engineered gene effectors targeting the synthetic site (TRE 3G) and the endogenous site (CD 45). The activation potency of the engineered gene effectors was compared with that of the standard activators VP64 and vCD (fig. 19A-19B).

While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Many modifications, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. The following claims are intended to define the scope of the invention and their equivalents and methods and structures within the scope of these claims and their equivalents are thereby covered.

TABLE 9 synthetic reporter cell line validation screen

Combined bar code	Base average_repeat	Log2 multiple change_repeat	LfcSC _repeat	Stat_repeat	P-value repeat	Padj _repeat
							AAAACAAGCATT _A_Concatenation ACTTGATGGTTT _B	7469.02185	-1.040403303	0.175382573	-5.932193182	2.99E-09	9.05E-09
AAAACAAGCATT _A_Concatenation AGAGTGCGCTCT _B	7387.267849	-1.086948505	0.194931444	-5.576055265	2.46E-08	6.83E-08
							AAAACAAGCATT _A_Concatenation ATAACTCCACGC _B	6061.978221	1.180519208	0.367776982	3.209877906	0.001327914	0.002240016
AAAACAAGCATT _A_Concatenation ATGACCCCTTGT _B	2403.749781	0.682247077	0.222536964	3.065769681	0.002171105	0.003491089
							AAAACAAGCATT _A_Concatenation CTACGTGGCCCC _B	8612.761707	-0.400581227	0.194525524	-2.059273354	0.03946806	0.054666068
AAAACAAGCATT _A_Concatenation GAGATTGTGTCC _B	6440.202817	-0.090413201	0.310217427	-0.291451069	0.770706361	0.800138309
							AAACTTTGAGCG _A_Concatenation ACTTGATGGTTT _B	13323.61535	2.387530537	0.270533511	8.825267261	1.09E-18	7.09E-18
AAACTTTGAGCG _A_Concatenation AGAGTGCGCTCT _B	22476.20917	-1.141426426	0.106625969	-10.70495709	9.65E-27	1.19E-25
							AAACTTTGAGCG _A_Concatenation ATAACTCCACGC _B	5482.672468	-0.789640258	0.255375687	-3.092072962	0.00198764	0.003222678
AAACTTTGAGCG _A_Concatenation ATGACCCCTTGT _B	2441.594848	1.208704527	0.921165047	1.312147623	0.18947033	0.232863979
							AAACTTTGAGCG _A_Concatenation CTACGTGGCCCC _B	6556.699452	0.903854866	0.418728636	2.158569506	0.030883581	0.043340823
AAACTTTGAGCG _A_Concatenation GAGATTGTGTCC _B	9320.034414	-0.161969825	0.280907028	-0.576595845	0.564212507	0.611840835
							AAGACCGGTGCC _A_Concatenation ACTTGATGGTTT _B	25897.64111	3.464806982	0.65886586	5.258744141	1.45E-07	3.74E-07
AAGACCGGTGCC _A_Concatenation AGAGTGCGCTCT _B	33374.15702	-1.003330918	0.122113515	-8.216378968	2.10E-16	1.12E-15
							AAGACCGGTGCC _A_Concatenation ATAACTCCACGC _B	1643.231853	1.795202191	0.509664247	3.522323181	0.000427782	0.000771725
AAGACCGGTGCC _A_Concatenation ATGACCCCTTGT _B	4009.103478	-0.453029757	0.209174418	-2.165799055	0.030326546	0.04266153
							AAGACCGGTGCC _A_Concatenation CTACGTGGCCCC _B	8409.892445	1.537955136	0.257238103	5.978722113	2.25E-09	6.96E-09
AAGACCGGTGCC _A_Concatenation GAGATTGTGTCC _B	13132.04427	2.593584989	0.411247838	6.306622788	2.85E-10	9.55E-10
							AAGCAACGATAT _A_Concatenation ACTTGATGGTTT _B	3378.329397	-1.323743527	0.41128631	-3.218545075	0.001288427	0.002179698
AAGCAACGATAT _A_Concatenation AGAGTGCGCTCT _B	3940.909635	-1.986502561	0.450370562	-4.410817953	1.03E-05	2.17E-05
							AAGCAACGATAT _A_Concatenation ATAACTCCACGC _B	2697.652523	-1.489541924	0.209024082	-7.126173742	1.03E-12	4.17E-12
AAGCAACGATAT _A_Concatenation ATGACCCCTTGT _B	869.8236778	-2.095312326	0.422387426	-4.960640862	7.03E-07	1.68E-06
							AAGCAACGATAT _A_Concatenation CTACGTGGCCCC _B	6484.719312	-3.075695623	0.248034305	-12.40028318	2.60E-35	5.07E-34
AAGCAACGATAT _A_Concatenation GAGATTGTGTCC _B	2509.268634	-0.411111801	0.276606552	-1.486269206	0.137207928	0.173027042
							AAGGGTAAATTG _A_Concatenation ACTTGATGGTTT _B	3262.476599	-0.355997737	0.422611495	-0.842375896	0.399577581	0.453501157
AAGGGTAAATTG _A_Concatenation AGAGTGCGCTCT _B	2887.363728	-1.810975681	0.447301992	-4.048664468	5.15E-05	0.000101034
							AAGGGTAAATTG _A_Concatenation ATAACTCCACGC _B	978.4522766	2.353539847	0.91146247	2.582157714	0.00981847	0.014715118
AAGGGTAAATTG _A_Concatenation ATGACCCCTTGT _B	791.385993	1.665402238	0.465170025	3.580201109	0.00034333	0.000627113
							AAGGGTAAATTG _A_Concatenation CTACGTGGCCCC _B	1003.98086	2.17909415	0.812043279	2.683470458	0.007286241	0.011134139
AAGGGTAAATTG _A_Concatenation GAGATTGTGTCC _B	1649.94748	1.424926374	0.406836948	3.502450747	0.000460999	0.000827815
							AATCAACGAGCA _A_Concatenation ACTTGATGGTTT _B	12070.22463	2.576730106	0.120841558	21.32321148	6.91E-101	1.15E-98
AATCAACGAGCA _A_Concatenation AGAGTGCGCTCT _B	13133.94992	-0.844786717	0.200644792	-4.210359548	2.55E-05	5.11E-05
							AATCAACGAGCA _A_Concatenation ATAACTCCACGC _B	1510.276102	0.615663624	0.673737859	0.913802921	0.360820411	0.415156556
AATCAACGAGCA _A_Concatenation ATGACCCCTTGT _B	1381.655393	-1.555051014	0.809373923	-1.921301107	0.054693758	0.074172857
							AATCAACGAGCA _A_Concatenation CTACGTGGCCCC _B	2764.999347	2.745767132	0.75190951	3.651725501	0.000260484	0.000481052
AATCAACGAGCA _A_Concatenation GAGATTGTGTCC _B	3731.257045	4.224890191	0.455970213	9.265715337	1.94E-20	1.45E-19
							AATCGAGACCAG _A_Concatenation ACTTGATGGTTT _B	2278.810307	4.842341098	0.497473125	9.733874768	2.16E-22	1.94E-21
AATCGAGACCAG _A_Concatenation AGAGTGCGCTCT _B	5190.119865	-0.203301362	0.245934378	-0.826648815	0.408436141	0.462208953
							AATCGAGACCAG _A_Concatenation ATAACTCCACGC _B	507.8189228	3.808431435	0.731717765	5.204781977	1.94E-07	4.97E-07
AATCGAGACCAG _A_Concatenation ATGACCCCTTGT _B	1756.9988	-2.14025026	0.628488836	-3.405391052	0.000660694	0.001172004
							AATCGAGACCAG _A_Concatenation CTACGTGGCCCC _B	882.0555616	2.424267755	0.982842294	2.46658876	0.013640692	0.020159252
AATCGAGACCAG _A_Concatenation GAGATTGTGTCC _B	824.0000993	2.200773775	1.458282534	1.509154587	0.131259282	0.166423103
							AATCGATCCTAC _A_Concatenation ACTTGATGGTTT _B	17339.39708	2.426968449	0.255050785	9.515628212	1.81E-21	1.52E-20
AATCGATCCTAC _A_Concatenation AGAGTGCGCTCT _B	22599.66373	-1.414848875	0.176516654	-8.015384622	1.10E-15	5.51E-15
							AATCGATCCTAC _A_Concatenation ATAACTCCACGC _B	2936.432464	0.928705312	0.52511793	1.76856523	0.076966458	0.101780304
AATCGATCCTAC _A_Concatenation ATGACCCCTTGT _B	1616.545275	0.232700454	0.828555812	0.280850668	0.778824939	0.807849471
							AATCGATCCTAC _A_Concatenation CTACGTGGCCCC _B	4446.73136	2.32772015	0.511829202	4.547845536	5.42E-06	1.20E-05
AATCGATCCTAC _A_Concatenation GAGATTGTGTCC _B	7729.401642	0.444776222	0.308954857	1.439615568	0.149976193	0.187110106
							AATGGCACTAGC _A_Concatenation ACTTGATGGTTT _B	10102.71102	-0.268726749	0.085880989	-3.129059804	0.001753666	0.002871198
AATGGCACTAGC _A_Concatenation AGAGTGCGCTCT _B	10306.49689	-1.186214715	0.292596039	-4.054103805	5.03E-05	9.89E-05
							AATGGCACTAGC _A_Concatenation ATAACTCCACGC _B	2919.532481	1.860377656	0.510029589	3.647587703	0.000264714	0.000488092
AATGGCACTAGC _A_Concatenation ATGACCCCTTGT _B	2118.166198	0.600955949	0.664566427	0.904282739	0.365845497	0.419699103
							AATGGCACTAGC _A_Concatenation CTACGTGGCCCC _B	6611.714743	2.735642296	0.286368727	9.552866776	1.26E-21	1.07E-20
AATGGCACTAGC _A_Concatenation GAGATTGTGTCC _B	5320.528702	1.864124959	0.376850975	4.946583887	7.55E-07	1.80E-06
							ACAACGTGCATA _A_Concatenation ACTTGATGGTTT _B	21971.69836	2.529439324	0.433294204	5.837694809	5.29E-09	1.55E-08
ACAACGTGCATA _A_Concatenation AGAGTGCGCTCT _B	31332.33425	0.439669885	0.092301795	4.763394721	1.90E-06	4.37E-06
							ACAACGTGCATA _A_Concatenation ATAACTCCACGC _B	2120.150699	0.160206921	0.455632511	0.351614332	0.725127516	0.762296822
ACAACGTGCATA _A_Concatenation ATGACCCCTTGT _B	595.738524	2.927637481	1.144503853	2.557997051	0.010527699	0.015717598
							ACAACGTGCATA _A_Concatenation CTACGTGGCCCC _B	2344.026099	0.334332536	0.385376996	0.867546687	0.385642543	0.439820617
ACAACGTGCATA _A_Concatenation GAGATTGTGTCC _B	2222.672156	1.792509699	0.665283327	2.694355361	0.007052493	0.010833593
							ACCAGTATTTAA _A_Concatenation ACTTGATGGTTT _B	6842.74488	2.911864238	0.225216677	12.92916793	3.08E-38	6.67E-37
ACCAGTATTTAA _A_Concatenation AGAGTGCGCTCT _B	11999.0185	-1.52760053	0.16119521	-9.476711712	2.62E-21	2.15E-20
							ACCAGTATTTAA _A_Concatenation ATAACTCCACGC _B	893.4465851	1.950587978	0.739965447	2.636052785	0.008387668	0.012750565
ACCAGTATTTAA _A_Concatenation ATGACCCCTTGT _B	1820.930458	-0.442283758	0.502796338	-0.87964793	0.379050065	0.433147142
							ACCAGTATTTAA _A_Concatenation CTACGTGGCCCC _B	3528.505796	1.127777138	0.508957386	2.215857691	0.02670125	0.037880778
ACCAGTATTTAA _A_Concatenation GAGATTGTGTCC _B	2324.79601	1.398548452	0.466655397	2.996961916	0.002726848	0.004342895
							ACGACTCACCGC _A_Concatenation ACTTGATGGTTT _B	3960.030496	-0.642872873	0.280369732	-2.292946778	0.021851069	0.031458005
ACGACTCACCGC _A_Concatenation AGAGTGCGCTCT _B	1717.102401	0.424418205	0.323890002	1.310377607	0.190068125	0.233147575
							ACGACTCACCGC _A_Concatenation ATAACTCCACGC _B	1894.570068	2.58861963	0.368778889	7.019435521	2.23E-12	8.74E-12
ACGACTCACCGC _A_Concatenation ATGACCCCTTGT _B	2044.618388	-0.340326224	0.468220124	-0.726850911	0.467317292	0.517814137
							ACGACTCACCGC _A_Concatenation CTACGTGGCCCC _B	3619.785732	-0.260639191	0.238633403	-1.092215875	0.274738226	0.326723282
ACGACTCACCGC _A_Concatenation GAGATTGTGTCC _B	4933.04858	0.453573298	0.149682824	3.030229421	0.00244368	0.003907883
							ACGGCGTAAGTA _A_Concatenation ACTTGATGGTTT _B	1811.61715	-0.487064438	0.382745341	-1.272554846	0.20317605	0.24715172
ACGGCGTAAGTA _A_Concatenation AGAGTGCGCTCT _B	1162.070148	-1.591657956	0.722312875	-2.203557504	0.027555479	0.038950852
							ACGGCGTAAGTA _A_Concatenation ATAACTCCACGC _B	4381.024234	-3.299574658	0.32018985	-10.30505701	6.69E-25	7.17E-24
ACGGCGTAAGTA _A_Concatenation ATGACCCCTTGT _B	514.0760198	-0.457951366	0.669465927	-0.684054777	0.493940577	0.544219165
							ACGGCGTAAGTA _A_Concatenation CTACGTGGCCCC _B	4299.137056	-3.323231079	0.230893709	-14.39290439	5.73E-47	1.92E-45
ACGGCGTAAGTA _A_Concatenation GAGATTGTGTCC _B	3104.860143	1.613015059	0.576126646	2.799757777	0.005114097	0.007949972
							ACTCGTGTTGTC _A_Concatenation ACTTGATGGTTT _B	1050.574385	1.622547696	0.510102131	3.180829086	0.001468542	0.002451286
ACTCGTGTTGTC _A_Concatenation AGAGTGCGCTCT _B	1322.899137	3.942212278	1.368158789	2.881399667	0.003959133	0.006220734
							ACTCGTGTTGTC _A_Concatenation ATAACTCCACGC _B	421.6768423	0.531799619	0.91774906	0.579460816	0.562278279	0.610309478
ACTCGTGTTGTC _A_Concatenation ATGACCCCTTGT _B	253.6992619	-1.977561462	1.263779197	-1.564799822	0.117629854	0.150612595
							ACTCGTGTTGTC _A_Concatenation CTACGTGGCCCC _B	1102.362215	-2.401459546	0.358660446	-6.695635316	2.15E-11	7.87E-11
ACTCGTGTTGTC _A_Concatenation GAGATTGTGTCC _B	599.6244131	-1.692520339	0.704063249	-2.403932234	0.01621978	0.023701153
							ACTTGATGGTTT _A_Concatenation AAAACAAGCATT _B	11348.04144	-0.631795346	0.147881135	-4.272318736	1.93E-05	3.93E-05
ACTTGATGGTTT _A_Concatenation AAACTTTGAGCG _B	4286.67209	3.621900716	0.700943248	5.167181121	2.38E-07	6.03E-07
							ACTTGATGGTTT _A_Concatenation AAGACCGGTGCC _B	32843.58417	3.007151918	0.321073975	9.365916121	7.54E-21	5.80E-20
ACTTGATGGTTT _A_Concatenation AAGCAACGATAT _B	11069.81009	-1.589382789	0.214342634	-7.415150028	1.21E-13	5.32E-13
							ACTTGATGGTTT _A_Concatenation AAGGGTAAATTG _B	16985.07741	-0.300132874	0.262953633	-1.141390864	0.253707305	0.305127407
ACTTGATGGTTT _A_Concatenation AATCAACGAGCA _B	14639.35486	0.774738674	0.327237448	2.367512271	0.017908126	0.026070485
							ACTTGATGGTTT _A_Concatenation AATCGAGACCAG _B	12317.3212	3.662739142	0.527232637	6.947102445	3.73E-12	1.43E-11
ACTTGATGGTTT _A_Concatenation AATCGATCCTAC _B	23440.72691	1.578956967	0.197417818	7.998046905	1.26E-15	6.29E-15
							ACTTGATGGTTT _A_Concatenation AATGGCACTAGC _B	16725.02771	-0.992954978	0.234060033	-4.24230898	2.21E-05	4.47E-05
ACTTGATGGTTT _A_Concatenation ACAACGTGCATA _B	12335.91093	2.652736942	0.590834304	4.489815371	7.13E-06	1.54E-05
							ACTTGATGGTTT _A_Concatenation ACCAGTATTTAA _B	11720.82305	4.047652121	0.215492651	18.78324899	1.04E-78	1.34E-76
ACTTGATGGTTT _A_Concatenation ACGACTCACCGC _B	7791.576043	-1.869186077	0.268761385	-6.954816357	3.53E-12	1.37E-11
							ACTTGATGGTTT _A_Concatenation ACGGCGTAAGTA _B	2913.817666	-1.369994186	0.171695678	-7.9792002	1.47E-15	7.26E-15
ACTTGATGGTTT _A_Concatenation ACTCGTGTTGTC _B	14530.75956	-1.363700034	0.299993635	-4.545763219	5.47E-06	1.21E-05
							ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B	23510.81628	2.238158842	0.248502199	9.006595734	2.13E-19	1.42E-18
ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B	10521.75788	1.641436377	0.509596554	3.221050777	0.001277215	0.002163862
							ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B	23510.81628	2.238158842	0.248502199	9.006595734	2.13E-19	1.42E-18
ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B	10521.75788	1.641436377	0.509596554	3.221050777	0.001277215	0.002163862
							ACTTGATGGTTT _A_Concatenation ACTTTAGTAACA _B	12277.19587	1.900877328	0.311006317	6.112021592	9.84E-10	3.13E-09
ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B	21276.8072	0.133140261	0.125115242	1.064141021	0.28726482	0.339349702
							ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B	11837.25375	-0.324609741	0.171120831	-1.896962157	0.057832933	0.078248494
ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B	21276.8072	0.133140261	0.125115242	1.064141021	0.28726482	0.339349702
							ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B	11837.25375	-0.324609741	0.171120831	-1.896962157	0.057832933	0.078248494
ACTTGATGGTTT _A_Concatenation AGCCAGGTCACC _B	5978.047799	2.107638151	0.413324039	5.099239226	3.41E-07	8.52E-07
							ACTTGATGGTTT _A_Concatenation AGCCATAAACCT _B	26726.26915	2.458905498	0.236799357	10.38391966	2.93E-25	3.27E-24
ACTTGATGGTTT _A_Concatenation AGCCGTGCTTGA _B	18594.33083	0.274028871	0.241248431	1.135878355	0.256007478	0.306958442
							ACTTGATGGTTT _A_Concatenation AGGCTTCCCGCT _B	14155.14134	-1.986380753	0.191866543	-10.35292931	4.06E-25	4.48E-24
ACTTGATGGTTT _A_Concatenation AGTTAGGCTCTT _B	25624.83108	3.209779933	0.260791446	12.30784206	8.22E-35	1.53E-33
							ACTTGATGGTTT _A_Concatenation AGTTGCTTTGCT _B	14935.50261	-1.727278751	0.127356031	-13.56259876	6.67E-42	1.90E-40
ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B	3444.014411	0.795533404	0.514101589	1.547424517	0.121760913	0.155391384
							ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B	2366.118225	2.564433254	0.805630394	3.183138661	0.001456878	0.002436467
ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B	3444.014411	0.795533404	0.514101589	1.547424517	0.121760913	0.155391384
							ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B	2366.118225	2.564433254	0.805630394	3.183138661	0.001456878	0.002436467
ACTTGATGGTTT _A_Concatenation ATCCAATCTGTG _B	2718.543771	2.237143787	0.570719735	3.919864074	8.86E-05	0.000169236
							ACTTGATGGTTT _A_Concatenation ATCTCTCAGTTC _B	19385.26089	1.736645584	0.183084737	9.485474405	2.41E-21	1.99E-20
ACTTGATGGTTT _A_Concatenation ATGACAAAACGA _B	27241.70132	3.096207993	0.437322045	7.079926637	1.44E-12	5.72E-12
							ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B	2812.370378	1.450251748	0.273379604	5.304901051	1.13E-07	2.95E-07
ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B	1623.761158	0.90573465	0.578114334	1.566705055	0.117183649	0.150205795
							ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B	2812.370378	1.450251748	0.273379604	5.304901051	1.13E-07	2.95E-07
ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B	1623.761158	0.90573465	0.578114334	1.566705055	0.117183649	0.150205795
							ACTTGATGGTTT _A_Concatenation ATGTGGCACGAC _B	58177.43919	0.206162766	0.158378429	1.301709877	0.193015582	0.236514901
ACTTGATGGTTT _A_Concatenation ATTGTATCTAAC _B	48074.83443	-0.344042899	0.151937482	-2.264371467	0.023551277	0.033739514
							ACTTGATGGTTT _A_Concatenation ATTTGTAGACCG _B	53805.29134	-1.473380947	0.14756178	-9.984841271	1.78E-23	1.69E-22
ACTTGATGGTTT _A_Concatenation CAACGCATGCCT _B	47706.65595	-1.793839835	0.070898002	-25.3016979	3.06E-141	1.79E-138
							ACTTGATGGTTT _A_Concatenation CACACCCGGCAG _B	23727.67497	3.822012097	0.467392341	8.177310071	2.90E-16	1.53E-15
ACTTGATGGTTT _A_Concatenation CAGTGACATAGT _B	60768.71893	-0.970787003	0.128294177	-7.566882792	3.82E-14	1.72E-13
							ACTTGATGGTTT _A_Concatenation CATCTCACCTAG _B	27692.38789	2.256177685	0.209312674	10.77898267	4.33E-27	5.56E-26
ACTTGATGGTTT _A_Concatenation CATCTGAGTCGT _B	25.17218896	4.063728066	0.630791559	6.442267671	1.18E-10	4.06E-10
							ACTTGATGGTTT _A_Concatenation CATGCTAACACC _B	7406.969113	1.297044065	0.217472678	5.964170203	2.46E-09	7.58E-09
ACTTGATGGTTT _A_Concatenation CATTAGTCCCGC _B	7157.117336	3.439595984	0.617479127	5.570384214	2.54E-08	7.04E-08
							ACTTGATGGTTT _A_Concatenation CATTGTTTAAAT _B	23796.72389	2.635085182	0.142744837	18.46010856	4.32E-76	4.60E-74
ACTTGATGGTTT _A_Concatenation CCAGACGGTCTG _B	20848.11149	-2.447165503	0.139140853	-17.58768501	3.06E-69	2.56E-67
							ACTTGATGGTTT _A_Concatenation CCCCTTAGGAAT _B	7011.335449	0.375257602	0.460126006	0.815553995	0.414755271	0.468324396
ACTTGATGGTTT _A_Concatenation CCCGTAGGGGCT _B	1330.549239	2.995010169	0.765340228	3.913305559	9.10E-05	0.000173617
							ACTTGATGGTTT _A_Concatenation CCCTATGTTCTA _B	8024.750138	2.499547228	0.357836611	6.98516348	2.85E-12	1.11E-11
ACTTGATGGTTT _A_Concatenation CCCTGCCTCGGG _B	22680.77655	-1.178843609	0.184397354	-6.392952942	1.63E-10	5.56E-10
							ACTTGATGGTTT _A_Concatenation CCGCCCTTATGT _B	5528.662203	0.737085845	0.32237339	2.286435134	0.022228815	0.031962466
ACTTGATGGTTT _A_Concatenation CCTAAATGCAAG _B	15691.99757	-1.359604525	0.096851137	-14.03808537	9.11E-45	2.88E-43
							ACTTGATGGTTT _A_Concatenation CGATGGCGGAAT _B	17032.98407	-1.27848825	0.14830826	-8.620479068	6.67E-18	4.08E-17
ACTTGATGGTTT _A_Concatenation CGCCGGCATACA _B	12007.4946	2.76621001	0.321540148	8.603000351	7.77E-18	4.73E-17
							ACTTGATGGTTT _A_Concatenation CGGCAATTGCTT _B	5866.518966	0.581497187	0.398491236	1.459247118	0.144497105	0.181047283
ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B	0.281036486	0.726896877	1.850372904	0.392838047	0.694439102	0.732670857
							ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B	2894.765866	2.169723115	0.409504488	5.298411078	1.17E-07	3.05E-07
ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B	0.281036486	0.726896877	1.850372904	0.392838047	0.694439102	0.732670857
							ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B	2894.765866	2.169723115	0.409504488	5.298411078	1.17E-07	3.05E-07
ACTTGATGGTTT _A_Concatenation CTCACGACAAGA _B	20348.57356	3.500106697	0.385612236	9.076752151	1.12E-19	7.74E-19
							ACTTGATGGTTT _A_Concatenation CTCAGCGATATA _B	7364.727988	1.330774984	0.375434154	3.544629521	0.000393165	0.000712574
ACTTGATGGTTT _A_Concatenation CTCCATTAATGA _B	26787.33915	-1.241430066	0.164883427	-7.529137961	5.11E-14	2.26E-13
							ACTTGATGGTTT _A_Concatenation CTCGCACCGAGG _B	27922.58349	-1.377034604	0.156877437	-8.77777349	1.67E-18	1.06E-17
ACTTGATGGTTT _A_Concatenation CTCGTTATGGCA _B	44007.63448	0.253869975	0.147561949	1.720429803	0.085354344	0.112363995
							ACTTGATGGTTT _A_Concatenation CTGCCGGTTGCG _B	3169.376672	-0.307354238	0.207547301	-1.480887666	0.13863651	0.174640173
ACTTGATGGTTT _A_Concatenation CTGGTAGTTGTT _B	34890.36969	-1.771205156	0.107528352	-16.47198265	5.83E-61	3.25E-59
							ACTTGATGGTTT _A_Concatenation EPICXV.47_B	5274.685908	4.07790674	0.412345065	9.889549029	4.62E-23	4.25E-22
ACTTGATGGTTT _A_Concatenation GACTGTGGGCGG _B	4105.529473	-1.332221678	0.332022169	-4.012447974	6.01E-05	0.000117275
							ACTTGATGGTTT _A_Concatenation GAGACAGCTCTC _B	6959.073104	-1.499620211	0.299145729	-5.013008932	5.36E-07	1.30E-06
ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	12355.41606	2.224680319	0.244339573	9.104871116	8.64E-20	6.05E-19
							ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	3364.574402	1.762887396	0.445733222	3.955028055	7.65E-05	0.000147136
ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	12355.41606	2.224680319	0.244339573	9.104871116	8.64E-20	6.05E-19
							ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B	3364.574402	1.762887396	0.445733222	3.955028055	7.65E-05	0.000147136
ACTTGATGGTTT _A_Concatenation GAGTGACCTATT _B	60120.39869	-1.304353047	0.183748766	-7.098567648	1.26E-12	5.01E-12
							ACTTGATGGTTT _A_Concatenation GATCGCATGTTC _B	24104.4819	-1.431446944	0.094146421	-15.20447536	3.30E-52	1.54E-50
ACTTGATGGTTT _A_Concatenation GATGGAGCTACA _B	12438.49421	3.589581259	0.675613269	5.313070986	1.08E-07	2.83E-07
							ACTTGATGGTTT _A_Concatenation GCAACGAGGGTC _B	20877.35209	1.262246261	0.298683226	4.226036652	2.38E-05	4.78E-05
ACTTGATGGTTT _A_Concatenation GCAGATTCGAAT _B	16318.83158	-1.763688062	0.202064934	-8.728323235	2.58E-18	1.62E-17
							ACTTGATGGTTT _A_Concatenation GCGAGGCAGACC _B	13351.03194	-1.219309005	0.267564765	-4.557061182	5.19E-06	1.15E-05
ACTTGATGGTTT _A_Concatenation GGAGGCACATCG _B	7052.202204	1.444556032	0.251446442	5.744984978	9.19E-09	2.63E-08
							ACTTGATGGTTT _A_Concatenation GGCACAGCTCCA _B	37300.51109	-1.402077424	0.059796379	-23.44753044	1.40E-121	4.09E-119
ACTTGATGGTTT _A_Concatenation GGCACTGTCGAG _B	15054.5403	-1.255639499	0.230112926	-5.456623067	4.85E-08	1.33E-07
							ACTTGATGGTTT _A_Concatenation GGCCTTTCGGGC _B	0
ACTTGATGGTTT _A_Concatenation GGGAGTATGTCG _B	17730.77851	-1.550267935	0.153286346	-10.11354225	4.81E-24	4.77E-23
							ACTTGATGGTTT _A_Concatenation GGTGTCTCGATT _B	6428.058698	2.748999755	0.333980808	8.23101115	1.86E-16	9.95E-16
ACTTGATGGTTT _A_Concatenation GTACATACCGAA _B	10899.68223	-0.659691584	0.20505116	-3.217204843	0.001294461	0.002186742
							ACTTGATGGTTT _A_Concatenation GTCACCCTCCTT _B	0
ACTTGATGGTTT _A_Concatenation GTTCCACGCCTG _B	21325.07703	0.450811167	0.10111479	4.458409759	8.26E-06	1.77E-05
							ACTTGATGGTTT _A_Concatenation Stop_1_B	13804.32691	1.724857541	0.216278965	7.975151616	1.52E-15	7.48E-15
ACTTGATGGTTT _A_Concatenation Stop_2_B	3287.77979	1.135060665	0.635855491	1.785092181	0.074246366	0.098629548
							ACTTGATGGTTT _A_Concatenation TAAAATTTATCA _B	26571.97322	2.383773214	0.414646225	5.748932625	8.98E-09	2.57E-08
ACTTGATGGTTT _A_Concatenation TAAGATTCAACG _B	4405.881968	1.477587592	0.290439702	5.087416015	3.63E-07	8.99E-07
							ACTTGATGGTTT _A_Concatenation TACATGAGGCAC _B	13869.68321	-1.228355939	0.376449029	-3.263007327	0.001102367	0.001895098
ACTTGATGGTTT _A_Concatenation TACTTCTAGCGG _B	8109.089692	-0.645954652	0.292350479	-2.209521441	0.027138393	0.038407725
							ACTTGATGGTTT _A_Concatenation TATCGCAAGAAC _B	13953.36033	-1.506506437	0.130941905	-11.50515138	1.24E-30	1.99E-29
ACTTGATGGTTT _A_Concatenation TATCTATCGTGT _B	14591.40113	0.973702501	0.20093994	4.845738976	1.26E-06	2.94E-06
							ACTTGATGGTTT _A_Concatenation TATTAAAAGTGC _B	7367.937758	-0.460206712	0.284750329	-1.616176225	0.106056217	0.13751427
ACTTGATGGTTT _A_Concatenation TCAGCCGTAGGC _B	26876.3203	-1.527159603	0.130127275	-11.73589171	8.34E-32	1.39E-30
							ACTTGATGGTTT _A_Concatenation TCTATCACAACT _B	2121.104892	2.1500662	0.603042776	3.565362669	0.000363353	0.00066162
ACTTGATGGTTT _A_Concatenation TCTGTACCAACG _B	36931.25192	3.147819184	0.37393897	8.418002491	3.83E-17	2.19E-16
							ACTTGATGGTTT _A_Concatenation TCTTAGAGGGTG _B	23558.69828	1.330773448	0.227088731	5.860147449	4.62E-09	1.37E-08
ACTTGATGGTTT _A_Concatenation TCTTGGTTTTGA _B	50323.07205	0.186804223	0.10245253	1.82332465	0.068254235	0.091396564
							ACTTGATGGTTT _A_Concatenation TGATGAGCGCCC _B	70545.70218	0.021496585	0.12639664	0.170072441	0.864953166	0.88470081
ACTTGATGGTTT _A_Concatenation TGCCAGACGGTC _B	12557.40674	1.401603217	0.256154991	5.471699822	4.46E-08	1.22E-07
							ACTTGATGGTTT _A_Concatenation TGGCCCCCAGTT _B	6539.248006	-0.960982659	0.224072914	-4.288705141	1.80E-05	3.67E-05
ACTTGATGGTTT _A_Concatenation TTAAATGAGGGC _B	5347.465633	-0.512750316	0.220548595	-2.324885885	0.020078063	0.029012677
							ACTTGATGGTTT _A_Concatenation TTAGTGCCATAC _B	0.183488719	0.044358346	2.991506868	0.014828094	0.988169326	0.98902379
ACTTGATGGTTT _A_Concatenation TTCTAATTTCCT _B	14127.8249	0.179146416	0.171883587	1.042254353	0.29729377	0.349282831
							ACTTGATGGTTT _A_Concatenation TTTAACGGATTG _B	44304.43602	-0.213902089	0.109226121	-1.958341899	0.050189907	0.068382286
ACTTGATGGTTT _A_Concatenation Joint_ 1_B	31875.21698	1.800860555	0.084001977	21.43831166	5.87E-102	1.14E-99
							ACTTGATGGTTT _A_Concatenation Joint_ 2_B	16691.71292	-0.379452151	0.17815157	-2.129939974	0.033176569	0.046170726
ACTTGATGGTTT _A_Concatenation Joint_ 3_B	32783.85568	-1.13412176	0.101996804	-11.1191892	1.01E-28	1.41E-27
							ACTTTAGTAACA _A_Concatenation ACTTGATGGTTT _B	2963.038326	4.261019241	0.876643213	4.860608261	1.17E-06	2.74E-06
ACTTTAGTAACA _A_Concatenation AGAGTGCGCTCT _B	12110.49046	0.973659107	0.162304339	5.998971523	1.99E-09	6.19E-09
							ACTTTAGTAACA _A_Concatenation ATAACTCCACGC _B	1287.293528	-0.626331121	0.845109051	-0.741124617	0.458617885	0.511081323
ACTTTAGTAACA _A_Concatenation ATGACCCCTTGT _B	849.0578421	2.664075567	1.397823684	1.905873822	0.056666578	0.076759247
							ACTTTAGTAACA _A_Concatenation CTACGTGGCCCC _B	909.7153413	1.41470307	0.879518788	1.608496701	0.107726438	0.139459807
ACTTTAGTAACA _A_Concatenation GAGATTGTGTCC _B	735.9230973	-0.056867808	0.4665382	-0.121893145	0.902983645	0.916308924
							AGAGTGCGCTCT _A_Concatenation AAAACAAGCATT _B	6033.159787	-0.155746341	0.277569475	-0.561107597	0.574724189	0.619218965
AGAGTGCGCTCT _A_Concatenation AAACTTTGAGCG _B	10228.12785	-0.932186953	0.207926676	-4.483248479	7.35E-06	1.58E-05
							AGAGTGCGCTCT _A_Concatenation AAGACCGGTGCC _B	41191.54044	-0.737585113	0.163474443	-4.511929188	6.42E-06	1.39E-05
AGAGTGCGCTCT _A_Concatenation AAGCAACGATAT _B	5633.946736	-0.611670302	0.235169673	-2.600974408	0.009295939	0.013967805
							AGAGTGCGCTCT _A_Concatenation AAGGGTAAATTG _B	10670.10963	-0.582342717	0.352807311	-1.650597077	0.098820876	0.129074418
AGAGTGCGCTCT _A_Concatenation AATCAACGAGCA _B	11504.19122	-1.770458353	0.254948573	-6.944374427	3.80E-12	1.46E-11
							AGAGTGCGCTCT _A_Concatenation AATCGAGACCAG _B	20018.94385	-1.472047551	0.175603745	-8.382779948	5.17E-17	2.92E-16
AGAGTGCGCTCT _A_Concatenation AATCGATCCTAC _B	32594.28193	-1.592096108	0.126982141	-12.53795293	4.63E-36	9.33E-35
							AGAGTGCGCTCT _A_Concatenation AATGGCACTAGC _B	17155.81157	-1.68078172	0.178021046	-9.441477584	3.68E-21	2.92E-20
AGAGTGCGCTCT _A_Concatenation ACAACGTGCATA _B	18144.4302	2.285378548	0.196534373	11.62839108	2.96E-31	4.80E-30
							AGAGTGCGCTCT _A_Concatenation ACCAGTATTTAA _B	14196.27815	-1.225276331	0.208773688	-5.868921247	4.39E-09	1.30E-08
AGAGTGCGCTCT _A_Concatenation ACGACTCACCGC _B	5267.181227	-1.479379014	0.260925115	-5.669745556	1.43E-08	4.06E-08
							AGAGTGCGCTCT _A_Concatenation ACGGCGTAAGTA _B	4592.246376	-1.915364087	0.432504585	-4.428540538	9.49E-06	2.02E-05
AGAGTGCGCTCT _A_Concatenation ACTCGTGTTGTC _B	8942.309464	-0.537136704	0.284731219	-1.886469306	0.059231741	0.079863789
							AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B	34027.9292	-0.095517739	0.12051819	-0.792558694	0.428034983	0.480204314
AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B	21799.75304	-0.423040087	0.175371358	-2.412253022	0.015854275	0.023225122
							AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B	34027.9292	-0.095517739	0.12051819	-0.792558694	0.428034983	0.480204314
AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B	21799.75304	-0.423040087	0.175371358	-2.412253022	0.015854275	0.023225122
							AGAGTGCGCTCT _A_Concatenation ACTTTAGTAACA _B	22527.40492	2.782076534	0.312839739	8.892976786	5.95E-19	3.93E-18
AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B	19878.82633	-0.90349002	0.165674946	-5.453389552	4.94E-08	1.34E-07
							AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B	27985.82161	-1.964934112	0.191794382	-10.2450035	1.25E-24	1.28E-23
AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B	19878.82633	-0.90349002	0.165674946	-5.453389552	4.94E-08	1.34E-07
							AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B	27985.82161	-1.964934112	0.191794382	-10.2450035	1.25E-24	1.28E-23
AGAGTGCGCTCT _A_Concatenation AGCCAGGTCACC _B	11269.61954	-1.221124506	0.160186687	-7.623133532	2.48E-14	1.14E-13
							AGAGTGCGCTCT _A_Concatenation AGCCATAAACCT _B	35439.58083	-1.332604906	0.128750667	-10.35027572	4.17E-25	4.56E-24
AGAGTGCGCTCT _A_Concatenation AGCCGTGCTTGA _B	15007.91566	-1.140028433	0.158417443	-7.196356744	6.18E-13	2.53E-12
							AGAGTGCGCTCT _A_Concatenation AGGCTTCCCGCT _B	7270.753356	-1.198870815	0.107498983	-11.15239218	6.97E-29	9.94E-28
AGAGTGCGCTCT _A_Concatenation AGTTAGGCTCTT _B	35993.42697	-1.022946924	0.086948761	-11.76493958	5.92E-32	1.00E-30
							AGAGTGCGCTCT _A_Concatenation AGTTGCTTTGCT _B	9600.80293	-2.095243758	0.491709745	-4.261139383	2.03E-05	4.12E-05
AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B	4368.413323	2.600302768	0.351804199	7.391335216	1.45E-13	6.29E-13
							AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B	7292.580394	3.175435695	0.447265037	7.09967342	1.25E-12	4.99E-12
AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B	4368.413323	2.600302768	0.351804199	7.391335216	1.45E-13	6.29E-13
							AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B	7292.580394	3.175435695	0.447265037	7.09967342	1.25E-12	4.99E-12
AGAGTGCGCTCT _A_Concatenation ATCCAATCTGTG _B	5674.111032	-2.115914765	0.325202807	-6.506446813	7.69E-11	2.72E-10
							AGAGTGCGCTCT _A_Concatenation ATCTCTCAGTTC _B	23264.18324	-0.955893264	0.098245278	-9.729661142	2.25E-22	2.01E-21
AGAGTGCGCTCT _A_Concatenation ATGACAAAACGA _B	43856.32043	-1.063368337	0.103226538	-10.30130775	6.95E-25	7.39E-24
							AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B	3527.175329	1.106080995	0.269686899	4.101352345	4.11E-05	8.12E-05
AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B	2580.14892	0.511089949	0.337069399	1.516275135	0.129449796	0.16430707
							AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B	3527.175329	1.106080995	0.269686899	4.101352345	4.11E-05	8.12E-05
AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B	2580.14892	0.511089949	0.337069399	1.516275135	0.129449796	0.16430707
							AGAGTGCGCTCT _A_Concatenation ATGTGGCACGAC _B	53298.10969	-1.432897875	0.12548039	-11.41929731	3.35E-30	5.15E-29
AGAGTGCGCTCT _A_Concatenation ATTGTATCTAAC _B	60235.27237	-2.070505821	0.139824513	-14.80788863	1.30E-49	5.64E-48
							AGAGTGCGCTCT _A_Concatenation ATTTGTAGACCG _B	51736.93229	-1.719692502	0.123974788	-13.87130832	9.45E-44	2.91E-42
AGAGTGCGCTCT _A_Concatenation CAACGCATGCCT _B	32541.69383	-1.480344288	0.101276066	-14.61692136	2.19E-48	8.54E-47
							AGAGTGCGCTCT _A_Concatenation CACACCCGGCAG _B	47072.06583	-0.031440973	0.133379504	-0.235725667	0.813645551	0.841083368
AGAGTGCGCTCT _A_Concatenation CAGTGACATAGT _B	64995.67641	-1.539689674	0.107804766	-14.28220409	2.83E-46	9.17E-45
							AGAGTGCGCTCT _A_Concatenation CATCTCACCTAG _B	42083.29921	-1.43140827	0.169507167	-8.444529505	3.05E-17	1.77E-16
AGAGTGCGCTCT _A_Concatenation CATCTGAGTCGT _B	27.49821134	-0.109897937	0.376733709	-0.291712514	0.77050644	0.800138309
							AGAGTGCGCTCT _A_Concatenation CATGCTAACACC _B	13533.50281	0.198004179	0.222031555	0.891783958	0.372508742	0.426506091
AGAGTGCGCTCT _A_Concatenation CATTAGTCCCGC _B	8939.484011	1.553096061	0.309808594	5.01308256	5.36E-07	1.30E-06
							AGAGTGCGCTCT _A_Concatenation CATTGTTTAAAT _B	39141.013	-1.665536019	0.136497895	-12.20191723	3.04E-34	5.55E-33
AGAGTGCGCTCT _A_Concatenation CCAGACGGTCTG _B	11633.30779	-1.534820737	0.215847191	-7.110682007	1.15E-12	4.62E-12
							AGAGTGCGCTCT _A_Concatenation CCCCTTAGGAAT _B	8786.667246	-1.559093298	0.210466493	-7.40779815	1.28E-13	5.60E-13
AGAGTGCGCTCT _A_Concatenation CCCGTAGGGGCT _B	902.3322126	-0.195429481	0.621573777	-0.314410756	0.753209088	0.786161986
							AGAGTGCGCTCT _A_Concatenation CCCTATGTTCTA _B	18634.33211	2.191312285	0.19235793	11.39184793	4.59E-30	6.88E-29
AGAGTGCGCTCT _A_Concatenation CCCTGCCTCGGG _B	19758.83273	-1.086481182	0.240077496	-4.525543634	6.02E-06	1.32E-05
							AGAGTGCGCTCT _A_Concatenation CCGCCCTTATGT _B	4752.680947	-1.009610709	0.284438949	-3.549481227	0.000385991	0.000700658
AGAGTGCGCTCT _A_Concatenation CCTAAATGCAAG _B	6912.916955	-0.399968294	0.277574525	-1.440940209	0.149601575	0.186842138
							AGAGTGCGCTCT _A_Concatenation CGATGGCGGAAT _B	14320.7978	-0.902087734	0.109493871	-8.238705313	1.74E-16	9.38E-16
AGAGTGCGCTCT _A_Concatenation CGCCGGCATACA _B	15401.13123	-0.311855318	0.191105759	-1.631846778	0.102711768	0.133708304
							AGAGTGCGCTCT _A_Concatenation CGGCAATTGCTT _B	4334.479328	0.009282783	0.30433099	0.03050226	0.975666491	0.980700024
AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B	0.392086388	1.202792688	1.824531867	0.659233587	0.509745782	0.558474995
							AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B	9094.364505	2.228847579	0.128365729	17.36326039	1.57E-67	1.22E-65
AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B	0.392086388	1.202792688	1.824531867	0.659233587	0.509745782	0.558474995
							AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B	9094.364505	2.228847579	0.128365729	17.36326039	1.57E-67	1.22E-65
AGAGTGCGCTCT _A_Concatenation CTCACGACAAGA _B	39072.8783	-1.173480079	0.155589187	-7.542169885	4.62E-14	2.05E-13
							AGAGTGCGCTCT _A_Concatenation CTCAGCGATATA _B	14655.2068	1.04341514	0.368768678	2.82945706	0.004662706	0.007267604
AGAGTGCGCTCT _A_Concatenation CTCCATTAATGA _B	26399.92626	-1.617829749	0.213552312	-7.575800664	3.57E-14	1.62E-13
							AGAGTGCGCTCT _A_Concatenation CTCGCACCGAGG _B	20772.61775	-0.961777507	0.128465103	-7.48668305	7.06E-14	3.12E-13
AGAGTGCGCTCT _A_Concatenation CTCGTTATGGCA _B	61065.0375	-1.533630176	0.09053593	-16.93946455	2.30E-64	1.58E-62
							AGAGTGCGCTCT _A_Concatenation CTGCCGGTTGCG _B	3812.240519	-0.433579644	0.326956078	-1.326109753	0.184803346	0.228114312
AGAGTGCGCTCT _A_Concatenation CTGGTAGTTGTT _B	22305.38956	-0.973623661	0.155752498	-6.251095001	4.08E-10	1.35E-09
							AGAGTGCGCTCT _A_Concatenation EPICXV.47_B	18187.41142	-0.365000024	0.155418429	-2.348498992	0.01884925	0.027304552
AGAGTGCGCTCT _A_Concatenation GACTGTGGGCGG _B	3815.059768	-2.260367427	0.267706514	-8.443453218	3.08E-17	1.77E-16
							AGAGTGCGCTCT _A_Concatenation GAGACAGCTCTC _B	5994.40584	-1.698361982	0.203401247	-8.349811068	6.84E-17	3.79E-16
AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B	24623.44113	1.928345443	0.218155072	8.839333528	9.63E-19	6.29E-18
							AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B	5810.881075	1.888395081	0.438249673	4.308948065	1.64E-05	3.36E-05
AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B	24623.44113	1.928345443	0.218155072	8.839333528	9.63E-19	6.29E-18
							AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B	5810.881075	1.888395081	0.438249673	4.308948065	1.64E-05	3.36E-05
AGAGTGCGCTCT _A_Concatenation GAGTGACCTATT _B	33464.45212	-1.09992603	0.145300196	-7.570024393	3.73E-14	1.68E-13
							AGAGTGCGCTCT _A_Concatenation GATCGCATGTTC _B	12611.75381	-1.446882813	0.203322207	-7.116206527	1.11E-12	4.46E-12
AGAGTGCGCTCT _A_Concatenation GATGGAGCTACA _B	14825.72328	0.179553735	0.177363072	1.01235129	0.31137012	0.364356026
							AGAGTGCGCTCT _A_Concatenation GCAACGAGGGTC _B	19689.44194	-1.210544129	0.168055978	-7.203219675	5.88E-13	2.41E-12
AGAGTGCGCTCT _A_Concatenation GCAGATTCGAAT _B	11224.51351	-0.99079831	0.123720835	-8.008338371	1.16E-15	5.81E-15
							AGAGTGCGCTCT _A_Concatenation GCGAGGCAGACC _B	12307.23558	-2.037732434	0.156364154	-13.0319666	8.05E-39	1.85E-37
AGAGTGCGCTCT _A_Concatenation GGAGGCACATCG _B	17523.94388	-1.352292005	0.159028454	-8.5034594	1.84E-17	1.08E-16
							AGAGTGCGCTCT _A_Concatenation GGCACAGCTCCA _B	38114.95954	-1.424605032	0.114588467	-12.43235963	1.74E-35	3.46E-34
AGAGTGCGCTCT _A_Concatenation GGCACTGTCGAG _B	15478.49194	-1.374277972	0.161915262	-8.487637012	2.11E-17	1.23E-16
							AGAGTGCGCTCT _A_Concatenation GGCCTTTCGGGC _B	0
AGAGTGCGCTCT _A_Concatenation GGGAGTATGTCG _B	13402.26725	-0.448251797	0.173540536	-2.582980361	0.00979509	0.014698922
							AGAGTGCGCTCT _A_Concatenation GGTGTCTCGATT _B	9906.050271	-1.375539887	0.287930835	-4.777327472	1.78E-06	4.09E-06
AGAGTGCGCTCT _A_Concatenation GTACATACCGAA _B	9942.343107	-1.567353712	0.323058711	-4.8516064	1.22E-06	2.86E-06
							AGAGTGCGCTCT _A_Concatenation GTCACCCTCCTT _B	0
AGAGTGCGCTCT _A_Concatenation GTTCCACGCCTG _B	19291.02111	-1.027585704	0.092184817	-11.14701684	7.40E-29	1.04E-27
							AGAGTGCGCTCT _A_Concatenation Stop_1_B	11562.22341	-0.888052625	0.242613979	-3.660352249	0.000251869	0.000465907
AGAGTGCGCTCT _A_Concatenation Stop_2_B	3594.014932	-0.641940522	0.245137399	-2.618696802	0.008826636	0.013348432
							AGAGTGCGCTCT _A_Concatenation TAAAATTTATCA _B	44324.43997	-1.330617426	0.16219277	-8.203925644	2.33E-16	1.24E-15
AGAGTGCGCTCT _A_Concatenation TAAGATTCAACG _B	6447.697441	-0.79471096	0.448399164	-1.772329263	0.076339916	0.101066095
							AGAGTGCGCTCT _A_Concatenation TACATGAGGCAC _B	12786.01925	-0.12579104	0.27858184	-0.451540706	0.651599894	0.690589552
AGAGTGCGCTCT _A_Concatenation TACTTCTAGCGG _B	14283.38156	-1.893816271	0.208480499	-9.083901262	1.05E-19	7.29E-19
							AGAGTGCGCTCT _A_Concatenation TATCGCAAGAAC _B	12734.728	-0.959094375	0.153574772	-6.245129745	4.23E-10	1.40E-09
AGAGTGCGCTCT _A_Concatenation TATCTATCGTGT _B	27074.27709	-1.649612488	0.202168425	-8.159595087	3.36E-16	1.76E-15
							AGAGTGCGCTCT _A_Concatenation TATTAAAAGTGC _B	7560.08828	-0.961426089	0.274441765	-3.503206191	0.000459693	0.000826741
AGAGTGCGCTCT _A_Concatenation TCAGCCGTAGGC _B	24177.75019	-1.43246823	0.105753123	-13.54539878	8.44E-42	2.35E-40
							AGAGTGCGCTCT _A_Concatenation TCTATCACAACT _B	1138.082118	0.109334762	0.730600143	0.149650617	0.881040272	0.898860105
AGAGTGCGCTCT _A_Concatenation TCTGTACCAACG _B	72199.37134	-0.569425391	0.119691147	-4.757456228	1.96E-06	4.48E-06
							AGAGTGCGCTCT _A_Concatenation TCTTAGAGGGTG _B	39651.78642	-1.493538372	0.093683724	-15.94234629	3.22E-57	1.57E-55
AGAGTGCGCTCT _A_Concatenation TCTTGGTTTTGA _B	54432.41593	-0.789839699	0.109269794	-7.228344373	4.89E-13	2.01E-12
							AGAGTGCGCTCT _A_Concatenation TGATGAGCGCCC _B	84684.34913	-1.21120068	0.132071122	-9.170821491	4.69E-20	3.37E-19
AGAGTGCGCTCT _A_Concatenation TGCCAGACGGTC _B	20810.05868	-0.266957474	0.13474745	-1.98116903	0.047572321	0.065119489
							AGAGTGCGCTCT _A_Concatenation TGGCCCCCAGTT _B	7644.614745	-0.988209594	0.411444442	-2.401805669	0.016314373	0.023809615
AGAGTGCGCTCT _A_Concatenation TTAAATGAGGGC _B	6669.436554	-1.621601725	0.313105775	-5.179085959	2.23E-07	5.67E-07
							AGAGTGCGCTCT _A_Concatenation TTAGTGCCATAC _B	0
AGAGTGCGCTCT _A_Concatenation TTCTAATTTCCT _B	14636.68577	-1.379627354	0.252187922	-5.470632151	4.48E-08	1.23E-07
							AGAGTGCGCTCT _A_Concatenation TTTAACGGATTG _B	40738.6395	-1.640455413	0.163094087	-10.05833776	8.44E-24	8.26E-23
AGAGTGCGCTCT _A_Concatenation Joint_ 1_B	51591.96883	-1.588659298	0.152424038	-10.42262968	1.95E-25	2.20E-24
							AGAGTGCGCTCT _A_Concatenation Joint_ 2_B	15751.06634	-1.240989184	0.247024803	-5.023743236	5.07E-07	1.23E-06
AGAGTGCGCTCT _A_Concatenation Joint_ 3_B	32307.69581	-1.361148548	0.190588443	-7.141821001	9.21E-13	3.75E-12
							AGCCAGGTCACC _A_Concatenation ACTTGATGGTTT _B	3876.885542	2.933466412	0.648056021	4.526563007	6.00E-06	1.31E-05
AGCCAGGTCACC _A_Concatenation AGAGTGCGCTCT _B	4703.493753	-2.22371757	0.208892734	-10.64526048	1.83E-26	2.23E-25
							AGCCAGGTCACC _A_Concatenation ATAACTCCACGC _B	2304.211004	-0.356341457	0.145827982	-2.443573937	0.014542589	0.021437941
AGCCAGGTCACC _A_Concatenation ATGACCCCTTGT _B	375.4169943	0.278787458	1.131464072	0.246395325	0.805376225	0.834649651
							AGCCAGGTCACC _A_Concatenation CTACGTGGCCCC _B	1184.16876	-1.776778994	0.443670782	-4.004723919	6.21E-05	0.000120972
AGCCAGGTCACC _A_Concatenation GAGATTGTGTCC _B	217.461885	6.607094185	0.600837958	10.99646602	3.97E-28	5.34E-27
							AGCCATAAACCT _A_Concatenation ACTTGATGGTTT _B	13375.49336	3.013120065	0.277859724	10.84403319	2.13E-27	2.80E-26
AGCCATAAACCT _A_Concatenation AGAGTGCGCTCT _B	10426.42815	-1.26195748	0.204589127	-6.168252926	6.90E-10	2.25E-09
							AGCCATAAACCT _A_Concatenation ATAACTCCACGC _B	850.8256228	0.241845958	0.426090493	0.567592945	0.570311399	0.615639761
AGCCATAAACCT _A_Concatenation ATGACCCCTTGT _B	2429.247465	-1.159170523	0.29238966	-3.964471671	7.36E-05	0.000142132
							AGCCATAAACCT _A_Concatenation CTACGTGGCCCC _B	5148.430924	2.092478249	0.324585885	6.446608881	1.14E-10	3.96E-10
AGCCATAAACCT _A_Concatenation GAGATTGTGTCC _B	6456.778216	2.340856302	0.354048729	6.611678313	3.80E-11	1.37E-10
							AGCCGTGCTTGA _A_Concatenation ACTTGATGGTTT _B	5785.441922	1.35549112	0.374919281	3.615421211	0.00029986	0.000550292
AGCCGTGCTTGA _A_Concatenation AGAGTGCGCTCT _B	12690.92634	-1.607501816	0.161011377	-9.983777824	1.79E-23	1.69E-22
							AGCCGTGCTTGA _A_Concatenation ATAACTCCACGC _B	2979.148998	3.683221787	0.721788828	5.102907724	3.34E-07	8.37E-07
AGCCGTGCTTGA _A_Concatenation ATGACCCCTTGT _B	2380.993825	1.572750431	0.40847404	3.850306939	0.00011797	0.000223875
							AGCCGTGCTTGA _A_Concatenation CTACGTGGCCCC _B	7907.712105	1.48870649	0.270220152	5.509235627	3.60E-08	9.94E-08
AGCCGTGCTTGA _A_Concatenation GAGATTGTGTCC _B	8157.516526	1.363374052	0.315947971	4.315185337	1.59E-05	3.30E-05
							AGGCTTCCCGCT _A_Concatenation ACTTGATGGTTT _B	632.1713156	-3.070103012	0.808141688	-3.798966267	0.000145301	0.000273082
AGGCTTCCCGCT _A_Concatenation AGAGTGCGCTCT _B	292.3239341	1.83039769	1.007941257	1.815976553	0.069373969	0.092366936
							AGGCTTCCCGCT _A_Concatenation ATAACTCCACGC _B	901.050346	1.501746738	0.342917638	4.37932194	1.19E-05	2.49E-05
AGGCTTCCCGCT _A_Concatenation ATGACCCCTTGT _B	711.0428879	-0.780548841	0.770628094	-1.012873586	0.311120546	0.364356026
							AGGCTTCCCGCT _A_Concatenation CTACGTGGCCCC _B	1176.063311	-2.150193866	0.561257627	-3.831028327	0.000127609	0.000241383
AGGCTTCCCGCT _A_Concatenation GAGATTGTGTCC _B	548.5680099	-3.156586506	0.848021575	-3.722295044	0.00019742	0.000367491
							AGTTAGGCTCTT _A_Concatenation ACTTGATGGTTT _B	5605.730546	3.744424746	0.372288115	10.05786807	8.48E-24	8.26E-23
AGTTAGGCTCTT _A_Concatenation AGAGTGCGCTCT _B	10599.81573	-1.231003918	0.152568423	-8.068536685	7.11E-16	3.60E-15
							AGTTAGGCTCTT _A_Concatenation ATAACTCCACGC _B	468.3853795	-0.374702354	0.771588973	-0.485624299	0.627233565	0.667184747
AGTTAGGCTCTT _A_Concatenation ATGACCCCTTGT _B	538.0462266	0.703649006	0.885463844	0.794667124	0.426807161	0.479286812
							AGTTAGGCTCTT _A_Concatenation CTACGTGGCCCC _B	3014.381588	0.707144378	0.227689923	3.105734184	0.001898073	0.003094626
AGTTAGGCTCTT _A_Concatenation GAGATTGTGTCC _B	1547.517664	2.37279869	0.748634071	3.16950401	0.001526994	0.002539197
							AGTTGCTTTGCT _A_Concatenation ACTTGATGGTTT _B	27530.83117	-1.300110378	0.213489037	-6.089822676	1.13E-09	3.58E-09
AGTTGCTTTGCT _A_Concatenation AGAGTGCGCTCT _B	24578.32868	-1.892474313	0.19285591	-9.812892514	9.91E-23	9.05E-22
							AGTTGCTTTGCT _A_Concatenation ATAACTCCACGC _B	36025.27381	-1.011930499	0.13416273	-7.542560429	4.61E-14	2.05E-13
AGTTGCTTTGCT _A_Concatenation ATGACCCCTTGT _B	10147.04038	-0.811060388	0.261981445	-3.095869586	0.001962366	0.00318612
							AGTTGCTTTGCT _A_Concatenation CTACGTGGCCCC _B	35065.60496	-1.827254606	0.126790701	-14.41158216	4.38E-47	1.50E-45
AGTTGCTTTGCT _A_Concatenation GAGATTGTGTCC _B	38128.24829	-1.272134012	0.237403833	-5.358523483	8.39E-08	2.24E-07
							ATAACTCCACGC _A_Concatenation AAAACAAGCATT _B	5781.56218	-0.281977919	0.343625126	-0.8205975	0.411875572	0.465650429
ATAACTCCACGC _A_Concatenation AAACTTTGAGCG _B	721.8533858	9.562160094	0.849940824	11.25038334	2.31E-29	3.37E-28
							ATAACTCCACGC _A_Concatenation AAGACCGGTGCC _B	497.2474192	0.853015176	0.999817168	0.853171163	0.393564392	0.447110568
ATAACTCCACGC _A_Concatenation AAGCAACGATAT _B	8353.976519	-0.632157946	0.223887962	-2.823545938	0.004749562	0.007393126
							ATAACTCCACGC _A_Concatenation AAGGGTAAATTG _B	7013.123501	1.90571259	0.293380387	6.49570548	8.26E-11	2.91E-10
ATAACTCCACGC _A_Concatenation AATCAACGAGCA _B	2455.688828	3.851581517	1.220691517	3.155245584	0.001603631	0.002655303
							ATAACTCCACGC _A_Concatenation AATCGAGACCAG _B	1570.999852	-0.376649214	0.64457388	-0.584338314	0.55899272	0.607872083
ATAACTCCACGC _A_Concatenation AATCGATCCTAC _B	4668.859977	2.182183543	0.295826024	7.376577331	1.62E-13	6.98E-13
							ATAACTCCACGC _A_Concatenation AATGGCACTAGC _B	11791.06528	2.110045297	0.173591782	12.15521423	5.38E-34	9.68E-33
ATAACTCCACGC _A_Concatenation ACAACGTGCATA _B	1296.972968	1.102299843	0.734703847	1.500332205	0.133528371	0.168933621
							ATAACTCCACGC _A_Concatenation ACCAGTATTTAA _B	835.1597014	0.035564837	0.552449978	0.064376574	0.948670382	0.957681932
ATAACTCCACGC _A_Concatenation ACGACTCACCGC _B	2291.736171	1.872071589	0.580311374	3.225977767	0.001255431	0.002130042
							ATAACTCCACGC _A_Concatenation ACGGCGTAAGTA _B	2977.097332	-1.439258583	0.306993319	-4.688240735	2.76E-06	6.27E-06
ATAACTCCACGC _A_Concatenation ACTCGTGTTGTC _B	10399.6518	-0.701415956	0.16107289	-4.354649355	1.33E-05	2.78E-05
							ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B	6841.681085	2.247520544	0.494571734	4.544377267	5.51E-06	1.22E-05
ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B	4455.372675	2.755782805	0.568485182	4.847589507	1.25E-06	2.92E-06
							ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B	6841.681085	2.247520544	0.494571734	4.544377267	5.51E-06	1.22E-05
ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B	4455.372675	2.755782805	0.568485182	4.847589507	1.25E-06	2.92E-06
							ATAACTCCACGC _A_Concatenation ACTTTAGTAACA _B	1756.52705	0.82079204	0.578444952	1.418963097	0.155909775	0.194098538
ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B	6993.8095	2.911441993	0.469851865	6.196510455	5.77E-10	1.91E-09
							ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B	9247.926929	2.887955818	0.487359009	5.925725733	3.11E-09	9.37E-09
ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B	6993.8095	2.911441993	0.469851865	6.196510455	5.77E-10	1.91E-09
							ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B	9247.926929	2.887955818	0.487359009	5.925725733	3.11E-09	9.37E-09
ATAACTCCACGC _A_Concatenation AGCCAGGTCACC _B	1809.954433	2.50899942	1.228434121	2.042437098	0.041108193	0.056736101
							ATAACTCCACGC _A_Concatenation AGCCATAAACCT _B	1162.529938	0.668422986	0.563393149	1.186423703	0.235455016	0.284934693
ATAACTCCACGC _A_Concatenation AGCCGTGCTTGA _B	5702.968247	4.674611784	0.89918899	5.198697756	2.01E-07	5.12E-07
							ATAACTCCACGC _A_Concatenation AGGCTTCCCGCT _B	13970.13395	-0.643955277	0.101978809	-6.314598927	2.71E-10	9.10E-10
ATAACTCCACGC _A_Concatenation AGTTAGGCTCTT _B	1041.716203	0.842129891	0.837817947	1.005146636	0.314826247	0.367664218
							ATAACTCCACGC _A_Concatenation AGTTGCTTTGCT _B	10571.52727	-0.944544869	0.208420795	-4.531912808	5.85E-06	1.28E-05
ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B	1807.962777	-1.477328676	0.456848505	-3.23373867	0.001221812	0.002085107
							ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B	1945.736553	-0.230079805	0.530743396	-0.43350479	0.664648087	0.702507788
ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B	1807.962777	-1.477328676	0.456848505	-3.23373867	0.001221812	0.002085107
							ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B	1945.736553	-0.230079805	0.530743396	-0.43350479	0.664648087	0.702507788
ATAACTCCACGC _A_Concatenation ATCCAATCTGTG _B	670.4549452	3.617897238	1.834944381	1.971665886	0.04864776	0.066513722
							ATAACTCCACGC _A_Concatenation ATCTCTCAGTTC _B	5115.335477	2.976746528	0.740686647	4.018901301	5.85E-05	0.000114492
ATAACTCCACGC _A_Concatenation ATGACAAAACGA _B	11998.35473	1.816229681	0.171140536	10.61250436	2.61E-26	3.05E-25
							ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B	493.2908764	1.096392366	1.209023925	0.906840918	0.364490928	0.418555889
ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B	2952.299029	-2.700001225	0.369427593	-7.308607354	2.70E-13	1.13E-12
							ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B	493.2908764	1.096392366	1.209023925	0.906840918	0.364490928	0.418555889
ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B	2952.299029	-2.700001225	0.369427593	-7.308607354	2.70E-13	1.13E-12
							ATAACTCCACGC _A_Concatenation ATGTGGCACGAC _B	8343.777904	2.192709064	0.197431018	11.10620351	1.17E-28	1.59E-27
ATAACTCCACGC _A_Concatenation ATTGTATCTAAC _B	14073.49262	3.130382563	0.346211959	9.041809447	1.54E-19	1.05E-18
							ATAACTCCACGC _A_Concatenation ATTTGTAGACCG _B	5217.056348	2.140235374	0.369918401	5.785695902	7.22E-09	2.09E-08
ATAACTCCACGC _A_Concatenation CAACGCATGCCT _B	39461.75006	-1.742323931	0.061184592	-28.47651452	2.29E-178	2.68E-175
							ATAACTCCACGC _A_Concatenation CACACCCGGCAG _B	2512.823989	0.947075381	0.188059149	5.036050563	4.75E-07	1.16E-06
ATAACTCCACGC _A_Concatenation CAGTGACATAGT _B	6765.912554	0.737299013	0.392584173	1.878066064	0.060372128	0.081307624
							ATAACTCCACGC _A_Concatenation CATCTCACCTAG _B	7005.809364	2.791173707	0.304577801	9.164074652	5.00E-20	3.56E-19
ATAACTCCACGC _A_Concatenation CATCTGAGTCGT _B	3.381350172	0.171617145	0.844943034	0.203110906	0.839048347	0.864182835
							ATAACTCCACGC _A_Concatenation CATGCTAACACC _B	3580.025369	3.154691462	0.369953295	8.527269526	1.50E-17	8.89E-17
ATAACTCCACGC _A_Concatenation CATTAGTCCCGC _B	2333.383375	-1.346253508	0.264142132	-5.096701154	3.46E-07	8.61E-07
							ATAACTCCACGC _A_Concatenation CATTGTTTAAAT _B	6192.8208	1.094617129	0.392402463	2.789526652	0.005278515	0.008194667
ATAACTCCACGC _A_Concatenation CCAGACGGTCTG _B	8419.710655	-0.253212435	0.261580139	-0.968010935	0.333038909	0.387000481
							ATAACTCCACGC _A_Concatenation CCCCTTAGGAAT _B	2146.458394	3.581362527	0.818314309	4.376512165	1.21E-05	2.52E-05
ATAACTCCACGC _A_Concatenation CCCGTAGGGGCT _B	85.13781885	8.907804866	1.859484601	4.790469821	1.66E-06	3.86E-06
							ATAACTCCACGC _A_Concatenation CCCTATGTTCTA _B	2636.302422	0.196741056	0.810125852	0.24285246	0.808119694	0.836751039
ATAACTCCACGC _A_Concatenation CCCTGCCTCGGG _B	26714.29552	-1.990321657	0.10114427	-19.6780466	3.33E-86	4.86E-84
							ATAACTCCACGC _A_Concatenation CCGCCCTTATGT _B	702.9559443	4.146369367	0.991222779	4.183085231	2.88E-05	5.75E-05
ATAACTCCACGC _A_Concatenation CCTAAATGCAAG _B	4358.852137	-2.995845265	0.291004002	-10.29485934	7.43E-25	7.83E-24
							ATAACTCCACGC _A_Concatenation CGATGGCGGAAT _B	14072.03242	-1.031916853	0.189252557	-5.452591325	4.96E-08	1.35E-07
ATAACTCCACGC _A_Concatenation CGCCGGCATACA _B	5744.325496	2.565332637	0.553808123	4.632168669	3.62E-06	8.13E-06
							ATAACTCCACGC _A_Concatenation CGGCAATTGCTT _B	7126.389565	-0.870154534	0.39864285	-2.182792276	0.029051111	0.040965921
ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B	0
							ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B	1817.585322	2.2821909	0.517260899	4.412069238	1.02E-05	2.16E-05
ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B	0
							ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B	1817.585322	2.2821909	0.517260899	4.412069238	1.02E-05	2.16E-05
ATAACTCCACGC _A_Concatenation CTCACGACAAGA _B	3284.680729	1.212962939	0.466326496	2.60110234	0.009292473	0.013967805
							ATAACTCCACGC _A_Concatenation CTCAGCGATATA _B	1563.906204	0.779959858	0.462978943	1.684655145	0.092055125	0.120777151
ATAACTCCACGC _A_Concatenation CTCCATTAATGA _B	23703.02195	-1.292269107	0.136860615	-9.442227842	3.65E-21	2.92E-20
							ATAACTCCACGC _A_Concatenation CTCGCACCGAGG _B	21139.06244	-1.22153884	0.223940597	-5.454744956	4.90E-08	1.34E-07
ATAACTCCACGC _A_Concatenation CTCGTTATGGCA _B	22341.62302	2.355927816	0.177415423	13.27916018	3.06E-40	7.61E-39
							ATAACTCCACGC _A_Concatenation CTGCCGGTTGCG _B	9169.143176	0.726762118	0.33826766	2.148482413	0.031675452	0.044345633
ATAACTCCACGC _A_Concatenation CTGGTAGTTGTT _B	24151.37555	-0.277450365	0.090276496	-3.07333998	0.002116772	0.003417826
							ATAACTCCACGC _A_Concatenation EPICXV.47_B	3434.755523	1.095957501	0.408255253	2.684490873	0.007264037	0.011114737
ATAACTCCACGC _A_Concatenation GACTGTGGGCGG _B	3337.186679	-1.928753721	0.324456748	-5.944563435	2.77E-09	8.48E-09
							ATAACTCCACGC _A_Concatenation GAGACAGCTCTC _B	5871.994573	-0.850703115	0.129432391	-6.572567393	4.95E-11	1.76E-10
ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B	1629.650511	1.262729308	0.377937217	3.341108662	0.000834446	0.001457207
							ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B	755.9126702	1.887817562	0.589565162	3.202050738	0.00136453	0.002298466
ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B	1629.650511	1.262729308	0.377937217	3.341108662	0.000834446	0.001457207
							ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B	755.9126702	1.887817562	0.589565162	3.202050738	0.00136453	0.002298466
ATAACTCCACGC _A_Concatenation GAGTGACCTATT _B	38898.01182	-0.835180179	0.140661781	-5.937506065	2.89E-09	8.79E-09
							ATAACTCCACGC _A_Concatenation GATCGCATGTTC _B	4723.657359	1.670471877	0.368062121	4.538559606	5.66E-06	1.25E-05
ATAACTCCACGC _A_Concatenation GATGGAGCTACA _B	3376.88519	0.195980857	0.450526895	0.43500368	0.663559757	0.701992177
							ATAACTCCACGC _A_Concatenation GCAACGAGGGTC _B	1533.503845	2.193515279	0.679686386	3.227246159	0.001249879	0.002123704
ATAACTCCACGC _A_Concatenation GCAGATTCGAAT _B	13594.38178	-1.309123082	0.16062805	-8.150027871	3.64E-16	1.90E-15
							ATAACTCCACGC _A_Concatenation GCGAGGCAGACC _B	15382.73155	-1.546709208	0.2631532	-5.877599838	4.16E-09	1.24E-08
ATAACTCCACGC _A_Concatenation GGAGGCACATCG _B	879.1416484	-0.819358772	0.709275781	-1.15520478	0.248006578	0.299194726
							ATAACTCCACGC _A_Concatenation GGCACAGCTCCA _B	11282.6646	3.164010295	0.29499216	10.72574367	7.71E-27	9.79E-26
ATAACTCCACGC _A_Concatenation GGCACTGTCGAG _B	8847.229774	2.325135133	0.347795244	6.685356324	2.30E-11	8.39E-11
							ATAACTCCACGC _A_Concatenation GGCCTTTCGGGC _B	0
ATAACTCCACGC _A_Concatenation GGGAGTATGTCG _B	17584.03076	-1.218503724	0.226940195	-5.369272395	7.91E-08	2.11E-07
							ATAACTCCACGC _A_Concatenation GGTGTCTCGATT _B	497.1435816	9.041134031	0.76585993	11.80520573	3.67E-32	6.31E-31
ATAACTCCACGC _A_Concatenation GTACATACCGAA _B	3938.166661	2.102611132	0.651451204	3.22758039	0.00124842	0.002123704
							ATAACTCCACGC _A_Concatenation GTCACCCTCCTT _B	0
ATAACTCCACGC _A_Concatenation GTTCCACGCCTG _B	2317.552	1.271545824	0.843551282	1.507372285	0.131715259	0.1668203
							ATAACTCCACGC _A_Concatenation Stop_1_B	1137.523105	0.798851374	0.749100475	1.066414187	0.286236451	0.339017641
ATAACTCCACGC _A_Concatenation Stop_2_B	233.468405	2.21612062	1.772497968	1.25028105	0.211196898	0.256641553
							ATAACTCCACGC _A_Concatenation TAAAATTTATCA _B	4067.861015	1.440863509	0.333820026	4.316288412	1.59E-05	3.29E-05
ATAACTCCACGC _A_Concatenation TAAGATTCAACG _B	1185.199721	0.887624512	0.936333252	0.947979269	0.343140008	0.397947093
							ATAACTCCACGC _A_Concatenation TACATGAGGCAC _B	10593.4815	-0.490193537	0.37106009	-1.321062408	0.186480556	0.229711033
ATAACTCCACGC _A_Concatenation TACTTCTAGCGG _B	2578.578079	1.640060548	0.156548042	10.47640407	1.11E-25	1.28E-24
							ATAACTCCACGC _A_Concatenation TATCGCAAGAAC _B	12563.11996	-1.389234571	0.2375299	-5.848672393	4.96E-09	1.46E-08
ATAACTCCACGC _A_Concatenation TATCTATCGTGT _B	826.0902795	1.246599869	0.473453515	2.632993167	0.008463605	0.012832626
							ATAACTCCACGC _A_Concatenation TATTAAAAGTGC _B	10622.84954	-1.544755007	0.15962284	-9.677531142	3.76E-22	3.30E-21
ATAACTCCACGC _A_Concatenation TCAGCCGTAGGC _B	8675.039943	3.049505983	0.573241137	5.319761241	1.04E-07	2.73E-07
							ATAACTCCACGC _A_Concatenation TCTATCACAACT _B	171.3249742	9.193956794	1.505962955	6.105035161	1.03E-09	3.26E-09
ATAACTCCACGC _A_Concatenation TCTGTACCAACG _B	2192.57237	1.757219114	0.745079347	2.358432189	0.018352312	0.026650749
							ATAACTCCACGC _A_Concatenation TCTTAGAGGGTG _B	2960.911399	1.698739618	0.489993821	3.466859263	0.000526578	0.000935515
ATAACTCCACGC _A_Concatenation TCTTGGTTTTGA _B	6725.138863	2.181554535	0.284761747	7.660981705	1.85E-14	8.59E-14
							ATAACTCCACGC _A_Concatenation TGATGAGCGCCC _B	9292.107714	1.386807308	0.260273879	5.32826157	9.92E-08	2.62E-07
ATAACTCCACGC _A_Concatenation TGCCAGACGGTC _B	4651.943894	2.879498645	0.367929728	7.826219049	5.03E-15	2.43E-14
							ATAACTCCACGC _A_Concatenation TGGCCCCCAGTT _B	6262.640698	-0.582854709	0.240531913	-2.423190761	0.015384846	0.022594076
ATAACTCCACGC _A_Concatenation TTAAATGAGGGC _B	4016.428413	-0.148634354	0.147244636	-1.009438156	0.312764547	0.365621756
							ATAACTCCACGC _A_Concatenation TTAGTGCCATAC _B	0
ATAACTCCACGC _A_Concatenation TTCTAATTTCCT _B	4520.477976	1.890478758	0.29031195	6.51188749	7.42E-11	2.63E-10
							ATAACTCCACGC _A_Concatenation TTTAACGGATTG _B	8109.13366	2.806610615	0.214137434	13.1065856	3.02E-39	7.06E-38
ATAACTCCACGC _A_Concatenation Joint_ 1_B	2209.767613	3.530393863	0.764919965	4.615376806	3.92E-06	8.80E-06
							ATAACTCCACGC _A_Concatenation Joint_ 2_B	9346.095048	2.797108229	0.456043474	6.133424534	8.60E-10	2.78E-09
ATAACTCCACGC _A_Concatenation Joint_ 3_B	17594.74342	2.26213997	0.245779647	9.20393529	3.45E-20	2.51E-19
							ATCCAATCTGTG _A_Concatenation ACTTGATGGTTT _B	5548.947268	2.872876554	0.403456794	7.120654801	1.07E-12	4.33E-12
ATCCAATCTGTG _A_Concatenation AGAGTGCGCTCT _B	9393.829084	-1.695062239	0.166799743	-10.16225932	2.92E-24	2.92E-23
							ATCCAATCTGTG _A_Concatenation ATAACTCCACGC _B	2942.355362	-1.834673755	0.288438472	-6.360710969	2.01E-10	6.80E-10
ATCCAATCTGTG _A_Concatenation ATGACCCCTTGT _B	311.3967368	-0.154913263	1.036349518	-0.149479747	0.88117509	0.898860105
							ATCCAATCTGTG _A_Concatenation CTACGTGGCCCC _B	2455.294276	-0.676441944	0.421373869	-1.605324853	0.108422333	0.140050505
ATCCAATCTGTG _A_Concatenation GAGATTGTGTCC _B	1602.806216	0.560867177	0.427537863	1.311853817	0.189569463	0.232863979
							ATCTCTCAGTTC _A_Concatenation ACTTGATGGTTT _B	6054.812689	2.486938892	0.528306637	4.707377723	2.51E-06	5.72E-06
ATCTCTCAGTTC _A_Concatenation AGAGTGCGCTCT _B	12589.08411	-1.652175566	0.174706148	-9.456882812	3.17E-21	2.58E-20
							ATCTCTCAGTTC _A_Concatenation ATAACTCCACGC _B	1832.88313	1.990900891	0.385509148	5.164341502	2.41E-07	6.11E-07
ATCTCTCAGTTC _A_Concatenation ATGACCCCTTGT _B	3537.004707	-1.266277279	0.588216121	-2.15274154	0.031338997	0.043927203
							ATCTCTCAGTTC _A_Concatenation CTACGTGGCCCC _B	6236.194184	0.903016357	0.317594115	2.843303178	0.004464858	0.006977832
ATCTCTCAGTTC _A_Concatenation GAGATTGTGTCC _B	3970.136403	4.141558093	0.658901102	6.285553447	3.27E-10	1.09E-09
							ATGACAAAACGA _A_Concatenation ACTTGATGGTTT _B	18237.28353	-1.650740096	0.187735162	-8.792919113	1.46E-18	9.31E-18
ATGACAAAACGA _A_Concatenation AGAGTGCGCTCT _B	9940.084266	-1.561917179	0.173246666	-9.015568469	1.96E-19	1.32E-18
							ATGACAAAACGA _A_Concatenation ATAACTCCACGC _B	24868.31806	-1.613728728	0.121979932	-13.22946075	5.93E-40	1.44E-38
ATGACAAAACGA _A_Concatenation ATGACCCCTTGT _B	13406.54463	-0.908494188	0.238889741	-3.802985364	0.000142963	0.00026912
							ATGACAAAACGA _A_Concatenation CTACGTGGCCCC _B	20209.35222	-1.496135662	0.161908491	-9.240625092	2.45E-20	1.80E-19
ATGACAAAACGA _A_Concatenation GAGATTGTGTCC _B	14692.50439	-1.319674258	0.220346731	-5.989080276	2.11E-09	6.56E-09
							ATGACCCCTTGT _A_Concatenation AAAACAAGCATT _B	2287.515275	-0.525536449	0.20023098	-2.624651031	0.008673781	0.013134262
ATGACCCCTTGT _A_Concatenation AAACTTTGAGCG _B	5.735324621	5.019891207	2.01835398	2.487121316	0.012878148	0.019104765
							ATGACCCCTTGT _A_Concatenation AAGACCGGTGCC _B	359.2014938	0.622596435	0.850207415	0.732287703	0.463992983	0.51510712
ATGACCCCTTGT _A_Concatenation AAGCAACGATAT _B	2767.974294	-0.083507557	0.282940013	-0.295142269	0.767885201	0.799317582
							ATGACCCCTTGT _A_Concatenation AAGGGTAAATTG _B	1704.08132	2.47354945	0.685362907	3.609109019	0.00030725	0.000562971
ATGACCCCTTGT _A_Concatenation AATCAACGAGCA _B	203.4996826	5.858636294	0.835955168	7.008313983	2.41E-12	9.43E-12
							ATGACCCCTTGT _A_Concatenation AATCGAGACCAG _B	996.684093	-1.715188982	0.914061994	-1.876447104	0.060593912	0.081512408
ATGACCCCTTGT _A_Concatenation AATCGATCCTAC _B	3062.76177	-3.489120362	0.393635252	-8.8638412	7.73E-19	5.08E-18
							ATGACCCCTTGT _A_Concatenation AATGGCACTAGC _B	7692.62048	0.922655547	0.271802059	3.394586307	0.000687324	0.001215554
ATGACCCCTTGT _A_Concatenation ACAACGTGCATA _B	878.2026969	2.02689206	0.604880538	3.350896471	0.000805504	0.001413865
							ATGACCCCTTGT _A_Concatenation ACCAGTATTTAA _B	216.6006839	1.894384791	1.352123072	1.401044646	0.161200723	0.200046332
ATGACCCCTTGT _A_Concatenation ACGACTCACCGC _B	2132.27275	-0.785126157	0.366168307	-2.14416743	0.032019474	0.044773642
							ATGACCCCTTGT _A_Concatenation ACGGCGTAAGTA _B	1043.756628	-1.055441727	1.085283276	-0.972503447	0.330800151	0.385164718
ATGACCCCTTGT _A_Concatenation ACTCGTGTTGTC _B	4628.537822	-0.442695862	0.273699911	-1.617449783	0.105781227	0.137398061
							ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B	2168.577771	2.949146111	0.371861607	7.93076257	2.18E-15	1.07E-14
ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B	1091.484458	-0.191776516	0.520528793	-0.368426336	0.712555363	0.749754473
							ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B	2168.577771	2.949146111	0.371861607	7.93076257	2.18E-15	1.07E-14
ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B	1091.484458	-0.191776516	0.520528793	-0.368426336	0.712555363	0.749754473
							ATGACCCCTTGT _A_Concatenation ACTTTAGTAACA _B	2367.858862	-1.264450711	0.375000206	-3.371866707	0.000746606	0.001318402
ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B	1136.121391	0.364815874	0.58990782	0.618428611	0.536292843	0.587009675
							ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B	1362.242812	0.71221897	0.46655236	1.526557424	0.126871101	0.161384458
ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B	1136.121391	0.364815874	0.58990782	0.618428611	0.536292843	0.587009675
							ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B	1362.242812	0.71221897	0.46655236	1.526557424	0.126871101	0.161384458
ATGACCCCTTGT _A_Concatenation AGCCAGGTCACC _B	785.8614332	-4.430915506	1.009266745	-4.390232343	1.13E-05	2.38E-05
							ATGACCCCTTGT _A_Concatenation AGCCATAAACCT _B	402.9449401	1.058582834	1.2987902	0.815052988	0.41504198	0.468324396
ATGACCCCTTGT _A_Concatenation AGCCGTGCTTGA _B	307.0305729	1.458530704	0.907567516	1.607076806	0.108037521	0.139707812
							ATGACCCCTTGT _A_Concatenation AGGCTTCCCGCT _B	3606.085282	-1.112953854	0.246859408	-4.508452261	6.53E-06	1.41E-05
ATGACCCCTTGT _A_Concatenation AGTTAGGCTCTT _B	1981.07778	3.623533786	1.089050337	3.327241786	0.000877102	0.001528067
							ATGACCCCTTGT _A_Concatenation AGTTGCTTTGCT _B	7349.196536	-1.816119282	0.309895761	-5.860419885	4.62E-09	1.37E-08
ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B	943.3389474	0.03640805	0.432512206	0.084178088	0.93291484	0.945041116
							ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B	524.4238384	-0.445256262	0.422703297	-1.053354125	0.292178721	0.344311416
ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B	943.3389474	0.03640805	0.432512206	0.084178088	0.93291484	0.945041116
							ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B	524.4238384	-0.445256262	0.422703297	-1.053354125	0.292178721	0.344311416
ATGACCCCTTGT _A_Concatenation ATCCAATCTGTG _B	109.7031691	-1.247649688	1.208046522	-1.032782816	0.301705547	0.354110226
							ATGACCCCTTGT _A_Concatenation ATCTCTCAGTTC _B	1058.096363	2.025692346	1.007609466	2.010394319	0.044389471	0.061120485
ATGACCCCTTGT _A_Concatenation ATGACAAAACGA _B	892.6541716	2.86904875	0.916476182	3.13052189	0.00174496	0.002860951
							ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B	577.6985671	0.675060337	0.780915191	0.864447695	0.387342001	0.440898539
ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B	317.8317371	0.75742988	1.119093522	0.67682447	0.49851733	0.547540563
							ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B	577.6985671	0.675060337	0.780915191	0.864447695	0.387342001	0.440898539
ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B	317.8317371	0.75742988	1.119093522	0.67682447	0.49851733	0.547540563
							ATGACCCCTTGT _A_Concatenation ATGTGGCACGAC _B	2466.27402	-1.296948223	0.297017273	-4.366575081	1.26E-05	2.63E-05
ATGACCCCTTGT _A_Concatenation ATTGTATCTAAC _B	1232.366084	0.999686076	0.777524593	1.285729205	0.198537585	0.242012969
							ATGACCCCTTGT _A_Concatenation ATTTGTAGACCG _B	1058.215722	0.422084209	0.694986449	0.60732725	0.543633757	0.593930159
ATGACCCCTTGT _A_Concatenation CAACGCATGCCT _B	14422.265	-1.675934858	0.220667353	-7.594847348	3.08E-14	1.41E-13
							ATGACCCCTTGT _A_Concatenation CACACCCGGCAG _B	1928.143102	-0.185253019	0.563474082	-0.32876937	0.742330017	0.776887905
ATGACCCCTTGT _A_Concatenation CAGTGACATAGT _B	1301.517589	0.548568316	0.361077174	1.519255039	0.128698312	0.16353079
							ATGACCCCTTGT _A_Concatenation CATCTCACCTAG _B	876.4882084	0.554139336	0.754077756	0.734857025	0.462426574	0.514002339
ATGACCCCTTGT _A_Concatenation CATCTGAGTCGT _B	0.365798231	1.018599464	1.87755126	0.542514863	0.587463871	0.631199693
							ATGACCCCTTGT _A_Concatenation CATGCTAACACC _B	1566.459453	-0.991486495	0.3268363	-3.033587437	0.002416647	0.003875254
ATGACCCCTTGT _A_Concatenation CATTAGTCCCGC _B	295.2280029	1.06692514	1.42240895	0.750083258	0.453204562	0.506497259
							ATGACCCCTTGT _A_Concatenation CATTGTTTAAAT _B	1307.809697	0.853441729	0.791323457	1.078499217	0.280811031	0.333267102
ATGACCCCTTGT _A_Concatenation CCAGACGGTCTG _B	1077.338153	-0.564467951	0.749696166	-0.752928956	0.451492607	0.505066849
							ATGACCCCTTGT _A_Concatenation CCCCTTAGGAAT _B	509.3493107	5.04210857	0.660310705	7.635963696	2.24E-14	1.04E-13
ATGACCCCTTGT _A_Concatenation CCCGTAGGGGCT _B	7.121212879	5.330137676	2.706598741	1.969312109	0.048917262	0.066804064
							ATGACCCCTTGT _A_Concatenation CCCTATGTTCTA _B	1486.11499	-0.350263211	0.404485887	-0.86594668	0.386519402	0.440391015
ATGACCCCTTGT _A_Concatenation CCCTGCCTCGGG _B	6951.478431	-1.497620447	0.151381786	-9.893002892	4.46E-23	4.14E-22
							ATGACCCCTTGT _A_Concatenation CCGCCCTTATGT _B	329.6625888	0.90963677	1.650708968	0.551058235	0.581593755	0.625467433
ATGACCCCTTGT _A_Concatenation CCTAAATGCAAG _B	4187.183258	-0.705756567	0.197454626	-3.574272126	0.000351204	0.000640494
							ATGACCCCTTGT _A_Concatenation CGATGGCGGAAT _B	7442.844876	-1.799683603	0.213924313	-8.412711869	4.01E-17	2.28E-16
ATGACCCCTTGT _A_Concatenation CGCCGGCATACA _B	2195.020751	0.376678768	0.216322731	1.741281496	0.081634248	0.107587865
							ATGACCCCTTGT _A_Concatenation CGGCAATTGCTT _B	1190.925959	0.048174904	0.644225311	0.074779588	0.940390083	0.950965404
ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B	0
							ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B	482.4955596	-0.478262205	0.957341742	-0.499573124	0.617375686	0.660303913
ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B	0
							ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B	482.4955596	-0.478262205	0.957341742	-0.499573124	0.617375686	0.660303913
ATGACCCCTTGT _A_Concatenation CTCACGACAAGA _B	668.2556154	4.680127047	1.253381716	3.733999777	0.000188463	0.000351937
							ATGACCCCTTGT _A_Concatenation CTCAGCGATATA _B	1360.519738	1.050055413	0.644611584	1.628973848	0.103318555	0.1343486
ATGACCCCTTGT _A_Concatenation CTCCATTAATGA _B	10519.93601	-0.811526433	0.242254393	-3.349893569	0.000808426	0.001416867
							ATGACCCCTTGT _A_Concatenation CTCGCACCGAGG _B	14533.13671	-1.656139684	0.331105628	-5.001846974	5.68E-07	1.37E-06
ATGACCCCTTGT _A_Concatenation CTCGTTATGGCA _B	1698.340302	1.04464085	0.61697245	1.693172603	0.090422618	0.118902182
							ATGACCCCTTGT _A_Concatenation CTGCCGGTTGCG _B	1782.029214	-0.898092237	0.364933969	-2.460971884	0.013856122	0.020451777
ATGACCCCTTGT _A_Concatenation CTGGTAGTTGTT _B	12224.64789	-1.075846971	0.202245607	-5.319507242	1.04E-07	2.73E-07
							ATGACCCCTTGT _A_Concatenation EPICXV.47_B	303.3712049	-3.073761593	0.934682791	-3.288561234	0.001007009	0.001733716
ATGACCCCTTGT _A_Concatenation GACTGTGGGCGG _B	1298.324089	-0.793184337	0.227623987	-3.484625443	0.000492826	0.000882257
							ATGACCCCTTGT _A_Concatenation GAGACAGCTCTC _B	4195.163522	-0.310077683	0.282390318	-1.098046439	0.272184211	0.324345916
ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B	885.7464797	-0.454030441	0.992465168	-0.457477457	0.647327902	0.686684499
							ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B	521.8273892	4.008315602	0.855559544	4.685022371	2.80E-06	6.35E-06
ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B	885.7464797	-0.454030441	0.992465168	-0.457477457	0.647327902	0.686684499
							ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B	521.8273892	4.008315602	0.855559544	4.685022371	2.80E-06	6.35E-06
ATGACCCCTTGT _A_Concatenation GAGTGACCTATT _B	11215.98758	-1.846011417	0.201625402	-9.155649047	5.40E-20	3.83E-19
							ATGACCCCTTGT _A_Concatenation GATCGCATGTTC _B	815.4825475	1.205367865	1.309436343	0.920524217	0.357298884	0.412268472
ATGACCCCTTGT _A_Concatenation GATGGAGCTACA _B	807.7004617	0.547613876	0.473697235	1.156041952	0.247663997	0.299090096
							ATGACCCCTTGT _A_Concatenation GCAACGAGGGTC _B	234.1471285	-0.832023953	1.026530525	-0.810520421	0.417641133	0.470802782
ATGACCCCTTGT _A_Concatenation GCAGATTCGAAT _B	7602.69883	-0.988303782	0.17105731	-5.777617935	7.58E-09	2.18E-08
							ATGACCCCTTGT _A_Concatenation GCGAGGCAGACC _B	5500.668748	-0.313088304	0.334070013	-0.93719368	0.34865894	0.403546833
ATGACCCCTTGT _A_Concatenation GGAGGCACATCG _B	7462.625076	8.72098559	1.350370488	6.458216963	1.06E-10	3.69E-10
							ATGACCCCTTGT _A_Concatenation GGCACAGCTCCA _B	4465.899797	1.790920936	0.597816081	2.995772436	0.002737506	0.004353939
ATGACCCCTTGT _A_Concatenation GGCACTGTCGAG _B	1562.659102	-0.617922189	0.282425217	-2.187914365	0.028675841	0.040485577
							ATGACCCCTTGT _A_Concatenation GGCCTTTCGGGC _B	0
ATGACCCCTTGT _A_Concatenation GGGAGTATGTCG _B	2476.152138	-0.521711314	0.467127552	-1.116849802	0.264058551	0.315628268
							ATGACCCCTTGT _A_Concatenation GGTGTCTCGATT _B	935.2907766	-2.079233258	0.724782835	-2.868767246	0.004120749	0.006457313
ATGACCCCTTGT _A_Concatenation GTACATACCGAA _B	933.5235491	1.654746947	0.739177606	2.238632412	0.025179843	0.035852907
							ATGACCCCTTGT _A_Concatenation GTCACCCTCCTT _B	0
ATGACCCCTTGT _A_Concatenation GTTCCACGCCTG _B	500.1774776	2.765118216	1.142249488	2.420765556	0.015487862	0.022716827
							ATGACCCCTTGT _A_Concatenation Stop_1_B	1555.398815	0.474188146	0.515456451	0.919938329	0.357604988	0.412268472
ATGACCCCTTGT _A_Concatenation Stop_2_B	0.612336762	0.5080298	1.467069773	0.346288779	0.729125701	0.765811271
							ATGACCCCTTGT _A_Concatenation TAAAATTTATCA _B	1329.875155	0.332647337	1.000211388	0.332577035	0.739453581	0.774571
ATGACCCCTTGT _A_Concatenation TAAGATTCAACG _B	436.4478317	2.473855484	1.914782095	1.291977552	0.196364919	0.239864775
							ATGACCCCTTGT _A_Concatenation TACATGAGGCAC _B	1511.794236	1.220926781	0.439402422	2.778607307	0.005459248	0.008452796
ATGACCCCTTGT _A_Concatenation TACTTCTAGCGG _B	478.5198881	0.693637766	0.944185972	0.734641041	0.462558136	0.514002339
							ATGACCCCTTGT _A_Concatenation TATCGCAAGAAC _B	4510.443005	-1.161403709	0.365360146	-3.178791451	0.001478905	0.002462734
ATGACCCCTTGT _A_Concatenation TATCTATCGTGT _B	279.5307797	2.212810566	0.972081277	2.276363735	0.022824248	0.032738094
							ATGACCCCTTGT _A_Concatenation TATTAAAAGTGC _B	3516.783324	-0.901112032	0.301380839	-2.989944663	0.00279028	0.004425831
ATGACCCCTTGT _A_Concatenation TCAGCCGTAGGC _B	948.4024368	0.368921854	0.832167168	0.443326615	0.657529508	0.696242749
							ATGACCCCTTGT _A_Concatenation TCTATCACAACT _B	0.475159289	1.425091302	2.107082379	0.676333928	0.498828656	0.547540563
ATGACCCCTTGT _A_Concatenation TCTGTACCAACG _B	665.2200161	0.15339516	0.962822562	0.159318203	0.87341818	0.892505116
							ATGACCCCTTGT _A_Concatenation TCTTAGAGGGTG _B	1950.570672	-0.987105007	0.293861742	-3.359079682	0.000782025	0.001374718
ATGACCCCTTGT _A_Concatenation TCTTGGTTTTGA _B	1129.693256	1.11859095	1.255485191	0.890963078	0.372948978	0.426592324
							ATGACCCCTTGT _A_Concatenation TGATGAGCGCCC _B	1606.678065	-0.011157164	0.63925852	-0.01745329	0.986074996	0.98902379
ATGACCCCTTGT _A_Concatenation TGCCAGACGGTC _B	5651.774607	0.012569397	0.274901214	0.045723324	0.963530774	0.969335176
							ATGACCCCTTGT _A_Concatenation TGGCCCCCAGTT _B	2714.044003	-0.595346355	0.402697842	-1.4783947	0.139302163	0.175289805
ATGACCCCTTGT _A_Concatenation TTAAATGAGGGC _B	1856.686977	0.147171198	0.282442378	0.521066277	0.602320602	0.646064294
							ATGACCCCTTGT _A_Concatenation TTAGTGCCATAC _B	0
ATGACCCCTTGT _A_Concatenation TTCTAATTTCCT _B	11195.00094	1.098253682	0.664274794	1.653312291	0.098267323	0.128494967
							ATGACCCCTTGT _A_Concatenation TTTAACGGATTG _B	1455.989183	-0.776645313	0.730019137	-1.063869799	0.287387686	0.339349702
ATGACCCCTTGT _A_Concatenation Joint_ 1_B	752.5198842	-1.444943888	1.263073794	-1.143990078	0.252627752	0.304141959
							ATGACCCCTTGT _A_Concatenation Joint_ 2_B	1110.470857	0.637154071	0.480671907	1.325548802	0.184989194	0.228114312
ATGACCCCTTGT _A_Concatenation Joint_ 3_B	3908.820494	0.040268554	0.236898364	0.169982405	0.865023974	0.88470081
							ATGTGGCACGAC _A_Concatenation ACTTGATGGTTT _B	5095.641866	2.448419689	0.421020313	5.815443132	6.05E-09	1.77E-08
ATGTGGCACGAC _A_Concatenation AGAGTGCGCTCT _B	6047.820627	-0.729866992	0.197292628	-3.699413405	0.000216098	0.000400983
							ATGTGGCACGAC _A_Concatenation ATAACTCCACGC _B	773.6173093	0.431277631	0.598620834	0.72045209	0.471246688	0.521673654
ATGTGGCACGAC _A_Concatenation ATGACCCCTTGT _B	1540.556675	-1.285062464	0.49890564	-2.575762552	0.010001931	0.014970879
							ATGTGGCACGAC _A_Concatenation CTACGTGGCCCC _B	1874.432834	2.300046892	0.579951321	3.965930947	7.31E-05	0.000141506
ATGTGGCACGAC _A_Concatenation GAGATTGTGTCC _B	6739.163558	-1.678747934	0.207190859	-8.102422761	5.39E-16	2.75E-15
							ATTGTATCTAAC _A_Concatenation ACTTGATGGTTT _B	24139.71307	1.352191287	0.218567775	6.186599503	6.15E-10	2.02E-09
ATTGTATCTAAC _A_Concatenation AGAGTGCGCTCT _B	23994.9063	-1.466219367	0.153272298	-9.566108058	1.11E-21	9.47E-21
							ATTGTATCTAAC _A_Concatenation ATAACTCCACGC _B	6980.824289	0.93531153	0.373705889	2.502801156	0.012321475	0.018302165
ATTGTATCTAAC _A_Concatenation ATGACCCCTTGT _B	1971.904722	0.642400748	0.246543575	2.605627624	0.00917061	0.013815004
							ATTGTATCTAAC _A_Concatenation CTACGTGGCCCC _B	8719.546707	1.909931947	0.360623875	5.296188293	1.18E-07	3.08E-07
ATTGTATCTAAC _A_Concatenation GAGATTGTGTCC _B	10818.52818	0.638717896	0.125131406	5.104377208	3.32E-07	8.33E-07
							ATTTGTAGACCG _A_Concatenation ACTTGATGGTTT _B	12449.504	-0.532255558	0.137232498	-3.878495005	0.000105105	0.000199784
ATTTGTAGACCG _A_Concatenation AGAGTGCGCTCT _B	10062.98179	-1.338155433	0.183240159	-7.302741059	2.82E-13	1.17E-12
							ATTTGTAGACCG _A_Concatenation ATAACTCCACGC _B	814.6974146	0.532632847	0.902539208	0.590149261	0.555090585	0.604190777
ATTTGTAGACCG _A_Concatenation ATGACCCCTTGT _B	1115.059329	-1.549811212	0.463508512	-3.343652107	0.000826834	0.001446959
							ATTTGTAGACCG _A_Concatenation CTACGTGGCCCC _B	5284.369087	0.678551148	0.157454497	4.309506299	1.64E-05	3.36E-05
ATTTGTAGACCG _A_Concatenation GAGATTGTGTCC _B	4476.743427	1.632420995	0.18068546	9.034600778	1.65E-19	1.12E-18
							CAACGCATGCCT _A_Concatenation ACTTGATGGTTT _B	7419.813011	-1.421461103	0.219245394	-6.483425159	8.97E-11	3.14E-10
CAACGCATGCCT _A_Concatenation AGAGTGCGCTCT _B	7073.509416	-0.916010416	0.212461993	-4.311408371	1.62E-05	3.34E-05
							CAACGCATGCCT _A_Concatenation ATAACTCCACGC _B	9827.361859	-1.034500129	0.161772056	-6.394801145	1.61E-10	5.51E-10
CAACGCATGCCT _A_Concatenation ATGACCCCTTGT _B	1105.304225	-0.966323948	0.307952527	-3.137899064	0.001701635	0.002797765
							CAACGCATGCCT _A_Concatenation CTACGTGGCCCC _B	9528.378512	-2.157771629	0.253692395	-8.505464378	1.81E-17	1.07E-16
CAACGCATGCCT _A_Concatenation GAGATTGTGTCC _B	10490.33969	-2.857159599	0.220524115	-12.95622292	2.17E-38	4.78E-37
							CACACCCGGCAG _A_Concatenation ACTTGATGGTTT _B	12305.95256	3.795537336	0.388192184	9.777469758	1.41E-22	1.27E-21
CACACCCGGCAG _A_Concatenation AGAGTGCGCTCT _B	28023.53979	0.013639503	0.142496975	0.09571784	0.923744672	0.936563332
							CACACCCGGCAG _A_Concatenation ATAACTCCACGC _B	3076.259048	2.355161651	0.506682838	4.648197012	3.35E-06	7.56E-06
CACACCCGGCAG _A_Concatenation ATGACCCCTTGT _B	6359.834091	-1.808272323	0.213103852	-8.485404222	2.15E-17	1.25E-16
							CACACCCGGCAG _A_Concatenation CTACGTGGCCCC _B	5164.160074	1.059695069	0.212060772	4.997129174	5.82E-07	1.40E-06
CACACCCGGCAG _A_Concatenation GAGATTGTGTCC _B	3805.636558	1.17417008	0.373102082	3.147047783	0.00164928	0.002719335
							CAGTGACATAGT _A_Concatenation ACTTGATGGTTT _B	4360.546813	0.679023926	0.215814314	3.14633406	0.00165331	0.002722141
CAGTGACATAGT _A_Concatenation AGAGTGCGCTCT _B	6252.181442	-2.070393053	0.154656159	-13.38707148	7.20E-41	1.83E-39
							CAGTGACATAGT _A_Concatenation ATAACTCCACGC _B	3918.571575	-1.722742868	0.326697176	-5.273210161	1.34E-07	3.47E-07
CAGTGACATAGT _A_Concatenation ATGACCCCTTGT _B	2241.253907	-0.072621927	0.146057456	-0.497214786	0.619037596	0.660918806
							CAGTGACATAGT _A_Concatenation CTACGTGGCCCC _B	3266.05954	-0.297932812	0.160916868	-1.851470366	0.064101914	0.085934791
CAGTGACATAGT _A_Concatenation GAGATTGTGTCC _B	5017.665716	0.013951149	0.226044692	0.061718544	0.950786972	0.958990484
							CATCTCACCTAG _A_Concatenation ACTTGATGGTTT _B	11946.44895	3.638856263	0.220133194	16.53024785	2.22E-61	1.37E-59
CATCTCACCTAG _A_Concatenation AGAGTGCGCTCT _B	16003.26959	-1.075382243	0.128420265	-8.373929479	5.57E-17	3.13E-16
							CATCTCACCTAG _A_Concatenation ATAACTCCACGC _B	3859.034055	-0.566270041	0.420046936	-1.348111349	0.177622572	0.2197257
CATCTCACCTAG _A_Concatenation ATGACCCCTTGT _B	1986.242644	1.391414284	0.790325411	1.760558709	0.078313123	0.103444113
							CATCTCACCTAG _A_Concatenation CTACGTGGCCCC _B	5844.460326	1.390616272	0.461339945	3.014298432	0.002575743	0.004113448
CATCTCACCTAG _A_Concatenation GAGATTGTGTCC _B	5403.645313	1.936581824	0.449375277	4.309497926	1.64E-05	3.36E-05
							CATCTGAGTCGT _A_Concatenation ACTTGATGGTTT _B	7217.684202	3.943917037	0.384336997	10.26161173	1.05E-24	1.09E-23
CATCTGAGTCGT _A_Concatenation AGAGTGCGCTCT _B	18368.28068	-1.277099226	0.112859198	-11.315863	1.10E-29	1.62E-28
							CATCTGAGTCGT _A_Concatenation ATAACTCCACGC _B	1588.843348	2.420260724	0.666019066	3.633921079	0.000279146	0.000513085
CATCTGAGTCGT _A_Concatenation ATGACCCCTTGT _B	897.3327052	-0.781425839	1.342679738	-0.581989745	0.560573588	0.609024651
							CATCTGAGTCGT _A_Concatenation CTACGTGGCCCC _B	1782.523095	1.608260208	0.274976646	5.848715625	4.95E-09	1.46E-08
CATCTGAGTCGT _A_Concatenation GAGATTGTGTCC _B	2732.22942	0.746913135	0.89373031	0.835725415	0.403309394	0.457292611
							CATGCTAACACC _A_Concatenation ACTTGATGGTTT _B	2149.110057	1.147353288	0.64736941	1.772331639	0.076339522	0.101066095
CATGCTAACACC _A_Concatenation AGAGTGCGCTCT _B	3918.207535	0.809065323	0.281976499	2.869265079	0.004114268	0.006455812
							CATGCTAACACC _A_Concatenation ATAACTCCACGC _B	1301.954231	0.185729359	0.325528617	0.570546949	0.568306788	0.614570431
CATGCTAACACC _A_Concatenation ATGACCCCTTGT _B	1519.002401	-2.194968027	0.332003084	-6.611288062	3.81E-11	1.37E-10
							CATGCTAACACC _A_Concatenation CTACGTGGCCCC _B	655.3439085	1.267264167	0.903566746	1.402513065	0.160762092	0.199714012
CATGCTAACACC _A_Concatenation GAGATTGTGTCC _B	357.3287364	2.234016085	1.245886488	1.793113665	0.072954751	0.097024009
							CATTAGTCCCGC _A_Concatenation ACTTGATGGTTT _B	5373.385514	2.311393706	0.240209383	9.622412221	6.43E-22	5.57E-21
CATTAGTCCCGC _A_Concatenation AGAGTGCGCTCT _B	11785.31091	-0.133471811	0.188900808	-0.706570883	0.479833189	0.53067644
							CATTAGTCCCGC _A_Concatenation ATAACTCCACGC _B	3205.555883	-1.053650808	0.391163138	-2.693635231	0.007067747	0.010842777
CATTAGTCCCGC _A_Concatenation ATGACCCCTTGT _B	3979.998108	-3.015937955	0.389643513	-7.740249361	9.92E-15	4.68E-14
							CATTAGTCCCGC _A_Concatenation CTACGTGGCCCC _B	3403.644957	-0.924091644	0.288917896	-3.19845761	0.001381648	0.002320614
CATTAGTCCCGC _A_Concatenation GAGATTGTGTCC _B	2536.550192	-0.889240951	0.437382374	-2.03309736	0.042042688	0.057957431
							CATTGTTTAAAT _A_Concatenation ACTTGATGGTTT _B	14303.36113	3.944358545	0.486788739	8.102813863	5.37E-16	2.75E-15
CATTGTTTAAAT _A_Concatenation AGAGTGCGCTCT _B	20511.17682	-1.552367967	0.145878579	-10.64150734	1.91E-26	2.30E-25
							CATTGTTTAAAT _A_Concatenation ATAACTCCACGC _B	2181.724046	1.759846351	0.765198434	2.299856184	0.021456369	0.030927861
CATTGTTTAAAT _A_Concatenation ATGACCCCTTGT _B	732.5492685	0.817619209	0.890944483	0.91769939	0.358776267	0.413211287
							CATTGTTTAAAT _A_Concatenation CTACGTGGCCCC _B	3285.122722	2.609998818	0.509403177	5.12364064	3.00E-07	7.53E-07
CATTGTTTAAAT _A_Concatenation GAGATTGTGTCC _B	2683.67616	1.184993478	0.287701286	4.118832748	3.81E-05	7.56E-05
							CCAGACGGTCTG _A_Concatenation ACTTGATGGTTT _B	8223.252539	-1.340416534	0.233808013	-5.732979462	9.87E-09	2.81E-08
CCAGACGGTCTG _A_Concatenation AGAGTGCGCTCT _B	7451.368311	-1.563258225	0.325597588	-4.801197196	1.58E-06	3.67E-06
							CCAGACGGTCTG _A_Concatenation ATAACTCCACGC _B	10467.93958	-0.191487445	0.262392227	-0.729775601	0.465527361	0.516320194
CCAGACGGTCTG _A_Concatenation ATGACCCCTTGT _B	1396.630034	-0.3794634	0.625593917	-0.606565041	0.544139606	0.593930159
							CCAGACGGTCTG _A_Concatenation CTACGTGGCCCC _B	9536.830883	-1.493867682	0.221391423	-6.74763125	1.50E-11	5.56E-11
CCAGACGGTCTG _A_Concatenation GAGATTGTGTCC _B	12886.20754	-0.737983045	0.232029654	-3.180554865	0.001469933	0.002451286
							CCCCTTAGGAAT _A_Concatenation ACTTGATGGTTT _B	12114.4044	1.640303072	0.397763095	4.123819159	3.73E-05	7.41E-05
CCCCTTAGGAAT _A_Concatenation AGAGTGCGCTCT _B	18800.88348	-1.895815142	0.146215244	-12.9659199	1.91E-38	4.29E-37
							CCCCTTAGGAAT _A_Concatenation ATAACTCCACGC _B	2493.416299	0.17498565	0.514836053	0.339886162	0.733942258	0.770178187
CCCCTTAGGAAT _A_Concatenation ATGACCCCTTGT _B	979.7426449	0.57270296	0.716587962	0.799208178	0.424169711	0.477241955
							CCCCTTAGGAAT _A_Concatenation CTACGTGGCCCC _B	4755.683253	0.6723488	0.489853627	1.372550417	0.169892155	0.210385518
CCCCTTAGGAAT _A_Concatenation GAGATTGTGTCC _B	4733.324715	2.229956362	0.877081145	2.542474405	0.011007066	0.016412322
							CCCGTAGGGGCT _A_Concatenation ACTTGATGGTTT _B	3767.976556	1.941885961	0.427959132	4.537550001	5.69E-06	1.25E-05
CCCGTAGGGGCT _A_Concatenation AGAGTGCGCTCT _B	9017.133556	-0.624429884	0.211892602	-2.946916877	0.003209595	0.005084033
							CCCGTAGGGGCT _A_Concatenation ATAACTCCACGC _B	1565.709678	0.631866807	0.436152941	1.448727608	0.147413667	0.184306499
CCCGTAGGGGCT _A_Concatenation ATGACCCCTTGT _B	644.7174587	-2.315772704	0.681709656	-3.397007338	0.000681271	0.001206676
							CCCGTAGGGGCT _A_Concatenation CTACGTGGCCCC _B	1758.536277	2.379765813	1.472676465	1.615946115	0.106105964	0.13751427
CCCGTAGGGGCT _A_Concatenation GAGATTGTGTCC _B	2056.702882	1.555989071	0.528424946	2.944579138	0.003233942	0.005115668
							CCCTATGTTCTA _A_Concatenation ACTTGATGGTTT _B	9585.621476	1.281474094	0.311264638	4.116992217	3.84E-05	7.61E-05
CCCTATGTTCTA _A_Concatenation AGAGTGCGCTCT _B	22519.92456	1.091908721	0.178459696	6.118517209	9.45E-10	3.02E-09
							CCCTATGTTCTA _A_Concatenation ATAACTCCACGC _B	4476.378542	-0.473947881	0.32241803	-1.469979455	0.141567318	0.17775746
CCCTATGTTCTA _A_Concatenation ATGACCCCTTGT _B	3851.487833	-0.725885908	0.301105707	-2.410734477	0.015920434	0.02329285
							CCCTATGTTCTA _A_Concatenation CTACGTGGCCCC _B	1961.488657	0.684350196	0.446388534	1.533081933	0.125255669	0.159677074
CCCTATGTTCTA _A_Concatenation GAGATTGTGTCC _B	5615.839237	-1.380460315	0.361795071	-3.815586301	0.00013586	0.000256162
							CCCTGCCTCGGG _A_Concatenation ACTTGATGGTTT _B	13706.93685	-2.025843128	0.236361474	-8.570953173	1.03E-17	6.22E-17
CCCTGCCTCGGG _A_Concatenation AGAGTGCGCTCT _B	4395.746943	-0.720679689	0.396410415	-1.818014012	0.069061991	0.09220222
							CCCTGCCTCGGG _A_Concatenation ATAACTCCACGC _B	10291.76466	-0.173235129	0.152515265	-1.135854366	0.25601752	0.306958442
CCCTGCCTCGGG _A_Concatenation ATGACCCCTTGT _B	1140.627367	-1.549313497	0.747535923	-2.072560594	0.038213192	0.053053707
							CCCTGCCTCGGG _A_Concatenation CTACGTGGCCCC _B	10152.64704	-0.991194945	0.160500384	-6.175654653	6.59E-10	2.15E-09
CCCTGCCTCGGG _A_Concatenation GAGATTGTGTCC _B	14253.85409	-1.669580159	0.114409503	-14.59301993	3.11E-48	1.17E-46
							CCGCCCTTATGT _A_Concatenation ACTTGATGGTTT _B	920.9953773	7.680540582	0.915405873	8.390311674	4.85E-17	2.75E-16
CCGCCCTTATGT _A_Concatenation AGAGTGCGCTCT _B	1514.582336	-0.391918069	0.365405424	-1.072556793	0.28347002	0.336081595
							CCGCCCTTATGT _A_Concatenation ATAACTCCACGC _B	64.94454274	8.517170106	1.781455677	4.78101713	1.74E-06	4.02E-06
CCGCCCTTATGT _A_Concatenation ATGACCCCTTGT _B	46.47763298	-0.99230683	1.413958346	-0.701793538	0.482807929	0.533461691
							CCGCCCTTATGT _A_Concatenation CTACGTGGCCCC _B	344.9398444	0.389994122	1.231620918	0.316651103	0.751508355	0.785087817
CCGCCCTTATGT _A_Concatenation GAGATTGTGTCC _B	279.830954	7.895667926	0.923688136	8.547980235	1.25E-17	7.47E-17
							CCTAAATGCAAG _A_Concatenation ACTTGATGGTTT _B	2319.402208	-2.39325174	0.286203924	-8.362050757	6.16E-17	3.45E-16
CCTAAATGCAAG _A_Concatenation AGAGTGCGCTCT _B	1522.603878	-1.127836336	0.308123728	-3.660335872	0.000251885	0.000465907
							CCTAAATGCAAG _A_Concatenation ATAACTCCACGC _B	1377.550391	-0.445092013	0.575862296	-0.772913969	0.439573297	0.492676112
CCTAAATGCAAG _A_Concatenation ATGACCCCTTGT _B	349.099442	1.716151465	0.965156408	1.778107103	0.075386266	0.10003013
							CCTAAATGCAAG _A_Concatenation CTACGTGGCCCC _B	497.1558333	0.547142923	0.958769489	0.570672023	0.568221987	0.614570431
CCTAAATGCAAG _A_Concatenation GAGATTGTGTCC _B	891.1928175	-1.154494628	0.440968466	-2.618088861	0.008842378	0.01335496
							CGATGGCGGAAT _A_Concatenation ACTTGATGGTTT _B	562.9838927	0.015138398	1.021654006	0.014817539	0.988177747	0.98902379
CGATGGCGGAAT _A_Concatenation AGAGTGCGCTCT _B	1130.648088	-1.163985128	0.698758477	-1.665790351	0.095755179	0.125490811
							CGATGGCGGAAT _A_Concatenation ATAACTCCACGC _B	541.8691076	-0.823311671	1.236196407	-0.666003935	0.505408585	0.554242623
CGATGGCGGAAT _A_Concatenation ATGACCCCTTGT _B	1670.880527	-5.614902708	0.923164854	-6.082231885	1.19E-09	3.73E-09
							CGATGGCGGAAT _A_Concatenation CTACGTGGCCCC _B	580.192006	1.716848853	1.093292956	1.570346578	0.116334503	0.149281048
CGATGGCGGAAT _A_Concatenation GAGATTGTGTCC _B	1787.592118	-0.178987543	0.258500038	-0.692408189	0.488681025	0.538932187
							CGCCGGCATACA _A_Concatenation ACTTGATGGTTT _B	7349.671117	2.357755315	0.467889257	5.039131118	4.68E-07	1.15E-06
CGCCGGCATACA _A_Concatenation AGAGTGCGCTCT _B	14868.66965	-0.555204161	0.170695658	-3.252596849	0.001143556	0.001963021
							CGCCGGCATACA _A_Concatenation ATAACTCCACGC _B	3363.201043	0.999578994	1.170468616	0.853998972	0.393105559	0.447023734
CGCCGGCATACA _A_Concatenation ATGACCCCTTGT _B	1171.087108	-0.424791624	0.569397984	-0.746036402	0.455645425	0.50873878
							CGCCGGCATACA _A_Concatenation CTACGTGGCCCC _B	2362.373098	2.216825278	0.850690562	2.605912628	0.009162983	0.013815004
CGCCGGCATACA _A_Concatenation GAGATTGTGTCC _B	1060.909951	1.201347941	0.453279028	2.650349709	0.008040849	0.012271218
							CGGCAATTGCTT _A_Concatenation ACTTGATGGTTT _B	0
CGGCAATTGCTT _A_Concatenation AGAGTGCGCTCT _B	0
							CGGCAATTGCTT _A_Concatenation ATAACTCCACGC _B	0
CGGCAATTGCTT _A_Concatenation ATGACCCCTTGT _B	0
							CGGCAATTGCTT _A_Concatenation CTACGTGGCCCC _B	0
CGGCAATTGCTT _A_Concatenation GAGATTGTGTCC _B	0
							CTACGTGGCCCC _A_Concatenation AAAACAAGCATT _B	9995.714008	-0.428803015	0.143315429	-2.992022678	0.002771357	0.004401788
CTACGTGGCCCC _A_Concatenation AAACTTTGAGCG _B	1502.767915	2.305731445	0.740849225	3.112281644	0.001856473	0.003031029
							CTACGTGGCCCC _A_Concatenation AAGACCGGTGCC _B	10785.24246	1.936743035	0.236167695	8.200711083	2.39E-16	1.26E-15
CTACGTGGCCCC _A_Concatenation AAGCAACGATAT _B	12038.37956	-1.355369685	0.355009618	-3.817839337	0.000134626	0.000254244
							CTACGTGGCCCC _A_Concatenation AAGGGTAAATTG _B	12102.24364	-0.470531276	0.388087464	-1.212436165	0.225345464	0.27326644
CTACGTGGCCCC _A_Concatenation AATCAACGAGCA _B	7094.232407	3.419168586	0.519147532	6.586121234	4.51E-11	1.61E-10
							CTACGTGGCCCC _A_Concatenation AATCGAGACCAG _B	2829.285345	4.678915085	0.778084069	6.013379876	1.82E-09	5.68E-09
CTACGTGGCCCC _A_Concatenation AATCGATCCTAC _B	9520.461054	3.254642759	0.284649602	11.43385671	2.83E-30	4.41E-29
							CTACGTGGCCCC _A_Concatenation AATGGCACTAGC _B	18314.94031	-0.43592875	0.185330676	-2.352167267	0.01866438	0.027070298
CTACGTGGCCCC _A_Concatenation ACAACGTGCATA _B	5234.170228	1.728268959	0.466560772	3.704274046	0.000211997	0.000393998
							CTACGTGGCCCC _A_Concatenation ACCAGTATTTAA _B	3425.963345	3.002088097	0.73482886	4.085424864	4.40E-05	8.67E-05
CTACGTGGCCCC _A_Concatenation ACGACTCACCGC _B	4670.921673	0.088456585	0.157437686	0.561851401	0.574217268	0.619218965
							CTACGTGGCCCC _A_Concatenation ACGGCGTAAGTA _B	1552.079293	-2.399873102	0.415027572	-5.782442571	7.36E-09	2.13E-08
CTACGTGGCCCC _A_Concatenation ACTCGTGTTGTC _B	11944.92523	-0.736553968	0.147401584	-4.996920311	5.83E-07	1.40E-06
							CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B	11551.28423	1.587956181	0.382028571	4.156642462	3.23E-05	6.44E-05
CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B	3972.048043	0.327161629	0.472084969	0.69301429	0.488300584	0.538932187
							CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B	11551.28423	1.587956181	0.382028571	4.156642462	3.23E-05	6.44E-05
CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B	3972.048043	0.327161629	0.472084969	0.69301429	0.488300584	0.538932187
							CTACGTGGCCCC _A_Concatenation ACTTTAGTAACA _B	5354.187064	-0.463095371	0.222088069	-2.085187977	0.037052241	0.051503055
CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B	17085.73655	0.788539819	0.125401725	6.288109804	3.21E-10	1.07E-09
							CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B	12307.05036	0.535323344	0.16900728	3.167457296	0.001537783	0.002553506
CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B	17085.73655	0.788539819	0.125401725	6.288109804	3.21E-10	1.07E-09
							CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B	12307.05036	0.535323344	0.16900728	3.167457296	0.001537783	0.002553506
CTACGTGGCCCC _A_Concatenation AGCCAGGTCACC _B	1136.55943	1.901178167	1.359680869	1.39825323	0.162037037	0.20087094
							CTACGTGGCCCC _A_Concatenation AGCCATAAACCT _B	12830.46762	3.072085653	0.228314337	13.45550913	2.86E-41	7.59E-40
CTACGTGGCCCC _A_Concatenation AGCCGTGCTTGA _B	12343.5194	0.139613203	0.206013139	0.677690774	0.497967777	0.547540563
							CTACGTGGCCCC _A_Concatenation AGGCTTCCCGCT _B	10356.15466	-0.843379431	0.214114828	-3.938911834	8.19E-05	0.000156604
CTACGTGGCCCC _A_Concatenation AGTTAGGCTCTT _B	11822.87803	2.246041671	0.304421612	7.378062469	1.61E-13	6.93E-13
							CTACGTGGCCCC _A_Concatenation AGTTGCTTTGCT _B	12953.38622	-1.440908575	0.242460548	-5.942857866	2.80E-09	8.55E-09
CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B	1831.525994	0.164864555	0.699763474	0.2356004	0.813742763	0.841083368
							CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B	2053.123089	0.045546261	0.316816823	0.143762128	0.885688309	0.901889925
CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B	1831.525994	0.164864555	0.699763474	0.2356004	0.813742763	0.841083368
							CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B	2053.123089	0.045546261	0.316816823	0.143762128	0.885688309	0.901889925
CTACGTGGCCCC _A_Concatenation ATCCAATCTGTG _B	3114.842864	2.520287753	0.555501973	4.53695554	5.71E-06	1.25E-05
							CTACGTGGCCCC _A_Concatenation ATCTCTCAGTTC _B	13802.3289	3.771621585	0.514650493	7.328510577	2.33E-13	9.86E-13
CTACGTGGCCCC _A_Concatenation ATGACAAAACGA _B	17734.13989	2.411483278	0.392766806	6.139732888	8.27E-10	2.68E-09
							CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B	950.1151898	2.652771902	0.339605108	7.811342751	5.66E-15	2.72E-14
CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B	1050.446502	-0.370077905	0.287481368	-1.287310924	0.197985938	0.241592444
							CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B	950.1151898	2.652771902	0.339605108	7.811342751	5.66E-15	2.72E-14
CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B	1050.446502	-0.370077905	0.287481368	-1.287310924	0.197985938	0.241592444
							CTACGTGGCCCC _A_Concatenation ATGTGGCACGAC _B	20487.6608	1.887721083	0.257877736	7.320217371	2.48E-13	1.04E-12
CTACGTGGCCCC _A_Concatenation ATTGTATCTAAC _B	18959.20939	1.502551182	0.273416685	5.49546265	3.90E-08	1.07E-07
							CTACGTGGCCCC _A_Concatenation ATTTGTAGACCG _B	19899.28901	0.973082807	0.193742925	5.022546269	5.10E-07	1.24E-06
CTACGTGGCCCC _A_Concatenation CAACGCATGCCT _B	44648.52901	-1.564371853	0.177549846	-8.810888261	1.24E-18	8.02E-18
							CTACGTGGCCCC _A_Concatenation CACACCCGGCAG _B	11325.87665	3.493793282	0.680660735	5.132943777	2.85E-07	7.19E-07
CTACGTGGCCCC _A_Concatenation CAGTGACATAGT _B	30955.90969	1.839559611	0.075625436	24.32461492	1.08E-130	4.19E-128
							CTACGTGGCCCC _A_Concatenation CATCTCACCTAG _B	9956.643988	1.281083965	0.262161517	4.88662096	1.03E-06	2.41E-06
CTACGTGGCCCC _A_Concatenation CATCTGAGTCGT _B	8.390306463	2.067232846	0.927075807	2.229842296	0.025757914	0.036631389
							CTACGTGGCCCC _A_Concatenation CATGCTAACACC _B	7489.117357	0.560918063	0.271833533	2.06346162	0.039068791	0.054177244
CTACGTGGCCCC _A_Concatenation CATTAGTCCCGC _B	1198.593846	1.562291149	0.728816101	2.14360131	0.032064846	0.044783518
							CTACGTGGCCCC _A_Concatenation CATTGTTTAAAT _B	8505.425357	1.467152345	0.202181437	7.256612502	3.97E-13	1.65E-12
CTACGTGGCCCC _A_Concatenation CCAGACGGTCTG _B	15173.55912	-1.62092495	0.174065653	-9.31214701	1.25E-20	9.51E-20
							CTACGTGGCCCC _A_Concatenation CCCCTTAGGAAT _B	4490.436985	2.348146093	0.281108338	8.353171272	6.65E-17	3.70E-16
CTACGTGGCCCC _A_Concatenation CCCGTAGGGGCT _B	384.699154	6.410387998	0.933137288	6.86971583	6.43E-12	2.44E-11
							CTACGTGGCCCC _A_Concatenation CCCTATGTTCTA _B	3021.105096	-0.252476773	0.371238411	-0.680093345	0.496445358	0.546463864
CTACGTGGCCCC _A_Concatenation CCCTGCCTCGGG _B	20559.72151	-0.955639078	0.143053369	-6.680297617	2.38E-11	8.66E-11
							CTACGTGGCCCC _A_Concatenation CCGCCCTTATGT _B	923.4517292	2.588344419	0.694558287	3.726605048	0.000194076	0.000361842
CTACGTGGCCCC _A_Concatenation CCTAAATGCAAG _B	10541.40504	-0.569930632	0.252623063	-2.256051465	0.024067408	0.03443672
							CTACGTGGCCCC _A_Concatenation CGATGGCGGAAT _B	19259.9293	-0.93143138	0.12738169	-7.312129216	2.63E-13	1.10E-12
CTACGTGGCCCC _A_Concatenation CGCCGGCATACA _B	3676.560558	2.873268172	0.825777767	3.479469035	0.000502408	0.000896665
							CTACGTGGCCCC _A_Concatenation CGGCAATTGCTT _B	2816.903216	0.715022949	0.348739526	2.050306593	0.040334522	0.055734108
CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B	0.050528823	-1.291682769	3.869099561	-0.333845834	0.738495895	0.774261616
							CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B	2607.57268	0.01359799	0.227015977	0.059898823	0.952236217	0.959624257
CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B	0.050528823	-1.291682769	3.869099561	-0.333845834	0.738495895	0.774261616
							CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B	2607.57268	0.01359799	0.227015977	0.059898823	0.952236217	0.959624257
CTACGTGGCCCC _A_Concatenation CTCACGACAAGA _B	4727.438679	1.774155744	0.531047059	3.340863515	0.000835183	0.001457207
							CTACGTGGCCCC _A_Concatenation CTCAGCGATATA _B	1870.982354	0.826140089	0.415758883	1.987065394	0.046915151	0.06437067
CTACGTGGCCCC _A_Concatenation CTCCATTAATGA _B	24021.04368	-1.408575352	0.116443974	-12.09659296	1.10E-33	1.95E-32
							CTACGTGGCCCC _A_Concatenation CTCGCACCGAGG _B	21704.72651	-0.48556436	0.243236705	-1.996262693	0.045905337	0.063133339
CTACGTGGCCCC _A_Concatenation CTCGTTATGGCA _B	20955.78015	3.020424424	0.24421828	12.36772457	3.91E-35	7.49E-34
							CTACGTGGCCCC _A_Concatenation CTGCCGGTTGCG _B	4601.952868	0.686146226	0.350866759	1.955574897	0.050515252	0.068745437
CTACGTGGCCCC _A_Concatenation CTGGTAGTTGTT _B	28428.95492	-0.995216768	0.20779412	-4.789436617	1.67E-06	3.87E-06
							CTACGTGGCCCC _A_Concatenation EPICXV.47_B	1874.838933	1.745258852	0.595822233	2.929160335	0.003398791	0.005361925
CTACGTGGCCCC _A_Concatenation GACTGTGGGCGG _B	2696.178552	0.151572686	0.471584843	0.321411275	0.74789874	0.782015766
							CTACGTGGCCCC _A_Concatenation GAGACAGCTCTC _B	5416.730231	-0.826601369	0.186697653	-4.427486659	9.53E-06	2.03E-05
CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B	7353.088648	0.724214392	0.165160539	4.384911784	1.16E-05	2.44E-05
							CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B	1349.54807	-0.40789886	0.313629932	-1.300573762	0.193404393	0.236743178
CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B	7353.088648	0.724214392	0.165160539	4.384911784	1.16E-05	2.44E-05
							CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B	1349.54807	-0.40789886	0.313629932	-1.300573762	0.193404393	0.236743178
CTACGTGGCCCC _A_Concatenation GAGTGACCTATT _B	50839.64172	-1.648692048	0.206319828	-7.990952996	1.34E-15	6.63E-15
							CTACGTGGCCCC _A_Concatenation GATCGCATGTTC _B	10539.06178	-1.36682814	0.210577157	-6.490866153	8.53E-11	3.00E-10
CTACGTGGCCCC _A_Concatenation GATGGAGCTACA _B	3892.323996	1.652497221	0.307243551	5.378460231	7.51E-08	2.01E-07
							CTACGTGGCCCC _A_Concatenation GCAACGAGGGTC _B	4001.257961	3.832368817	0.322159989	11.89585594	1.24E-32	2.17E-31
CTACGTGGCCCC _A_Concatenation GCAGATTCGAAT _B	17457.31343	-1.618131233	0.173888316	-9.305577689	1.33E-20	1.01E-19
							CTACGTGGCCCC _A_Concatenation GCGAGGCAGACC _B	12287.75963	-1.483345806	0.255087307	-5.815051412	6.06E-09	1.77E-08
CTACGTGGCCCC _A_Concatenation GGAGGCACATCG _B	7113.897887	-0.068571362	0.535643644	-0.128016756	0.898135713	0.912181275
							CTACGTGGCCCC _A_Concatenation GGCACAGCTCCA _B	30174.64994	0.100923308	0.111749975	0.90311706	0.366463771	0.419996223
CTACGTGGCCCC _A_Concatenation GGCACTGTCGAG _B	12685.3025	-0.944676466	0.250777254	-3.766994212	0.000165225	0.000310029
							CTACGTGGCCCC _A_Concatenation GGCCTTTCGGGC _B	0
CTACGTGGCCCC _A_Concatenation GGGAGTATGTCG _B	12443.62218	-1.536299005	0.228968755	-6.709644754	1.95E-11	7.19E-11
							CTACGTGGCCCC _A_Concatenation GGTGTCTCGATT _B	2190.706918	3.737178336	0.321297447	11.63152205	2.85E-31	4.69E-30
CTACGTGGCCCC _A_Concatenation GTACATACCGAA _B	8574.331557	0.843789417	0.289412463	2.915525499	0.003550901	0.005594344
							CTACGTGGCCCC _A_Concatenation GTCACCCTCCTT _B	0
CTACGTGGCCCC _A_Concatenation GTTCCACGCCTG _B	7600.094339	1.963358831	0.253415918	7.747575002	9.37E-15	4.45E-14
							CTACGTGGCCCC _A_Concatenation Stop_1_B	5522.844032	2.67554007	0.870832724	3.072392662	0.002123502	0.003423964
CTACGTGGCCCC _A_Concatenation Stop_2_B	1681.917788	1.435028374	1.246044484	1.151667049	0.249457918	0.300635367
							CTACGTGGCCCC _A_Concatenation TAAAATTTATCA _B	8180.859527	1.935216539	0.380137656	5.090830933	3.56E-07	8.85E-07
CTACGTGGCCCC _A_Concatenation TAAGATTCAACG _B	3954.42675	2.273555948	0.684904609	3.319522044	0.000901717	0.001561877
							CTACGTGGCCCC _A_Concatenation TACATGAGGCAC _B	10534.22985	-1.05049681	0.196904025	-5.335070268	9.55E-08	2.53E-07
CTACGTGGCCCC _A_Concatenation TACTTCTAGCGG _B	4153.796307	2.155327639	0.4861279	4.433663729	9.26E-06	1.98E-05
							CTACGTGGCCCC _A_Concatenation TATCGCAAGAAC _B	15884.14259	-1.241494587	0.211192248	-5.87850452	4.14E-09	1.24E-08
CTACGTGGCCCC _A_Concatenation TATCTATCGTGT _B	398.3921212	-0.56349983	0.521921	-1.079664987	0.280291391	0.332988451
							CTACGTGGCCCC _A_Concatenation TATTAAAAGTGC _B	8918.26617	-0.65918521	0.236435031	-2.788018368	0.005303154	0.008221998
CTACGTGGCCCC _A_Concatenation TCAGCCGTAGGC _B	26006.54953	-1.095796534	0.1151699	-9.514608737	1.82E-21	1.52E-20
							CTACGTGGCCCC _A_Concatenation TCTATCACAACT _B	283.6516595	1.363817389	1.845951365	0.73881545	0.460019069	0.512154563
CTACGTGGCCCC _A_Concatenation TCTGTACCAACG _B	22581.14821	2.378339087	0.176941006	13.44142404	3.46E-41	8.98E-40
							CTACGTGGCCCC _A_Concatenation TCTTAGAGGGTG _B	8432.5081	3.317190139	0.298511555	11.11243464	1.09E-28	1.50E-27
CTACGTGGCCCC _A_Concatenation TCTTGGTTTTGA _B	18540.96686	1.866446198	0.182522584	10.22583704	1.52E-24	1.53E-23
							CTACGTGGCCCC _A_Concatenation TGATGAGCGCCC _B	40064.30796	0.910760623	0.229646806	3.965918968	7.31E-05	0.000141506
CTACGTGGCCCC _A_Concatenation TGCCAGACGGTC _B	11614.94098	1.512919413	0.290403076	5.209722402	1.89E-07	4.85E-07
							CTACGTGGCCCC _A_Concatenation TGGCCCCCAGTT _B	9562.072512	-1.711727411	0.224103565	-7.638108802	2.20E-14	1.02E-13
CTACGTGGCCCC _A_Concatenation TTAAATGAGGGC _B	4456.141083	-0.806234392	0.207263217	-3.889905813	0.000100283	0.00019093
							CTACGTGGCCCC _A_Concatenation TTAGTGCCATAC _B	0
CTACGTGGCCCC _A_Concatenation TTCTAATTTCCT _B	17717.96749	-0.207761382	0.202788232	-1.02452386	0.305587907	0.358307185
							CTACGTGGCCCC _A_Concatenation TTTAACGGATTG _B	22952.00753	0.913913801	0.141577678	6.455211124	1.08E-10	3.75E-10
CTACGTGGCCCC _A_Concatenation Joint_ 1_B	9569.397796	2.449199321	0.343065543	7.139158598	9.39E-13	3.81E-12
							CTACGTGGCCCC _A_Concatenation Joint_ 2_B	18612.82245	-0.64014566	0.084456667	-7.579575185	3.47E-14	1.58E-13
CTACGTGGCCCC _A_Concatenation Joint_ 3_B	23642.08197	-1.240754822	0.091948981	-13.49394853	1.70E-41	4.62E-40
							CTCACGACAAGA _A_Concatenation ACTTGATGGTTT _B	6395.112661	3.880306999	0.524264206	7.40143415	1.35E-13	5.85E-13
CTCACGACAAGA _A_Concatenation AGAGTGCGCTCT _B	15677.68144	-0.741292505	0.089003166	-8.328832966	8.16E-17	4.50E-16
							CTCACGACAAGA _A_Concatenation ATAACTCCACGC _B	2044.350463	-0.663463213	0.466478541	-1.422280244	0.154944912	0.193102987
CTCACGACAAGA _A_Concatenation ATGACCCCTTGT _B	640.6129647	1.368113686	0.86785586	1.576429622	0.114926826	0.147636769
							CTCACGACAAGA _A_Concatenation CTACGTGGCCCC _B	1663.271467	2.300705548	1.53796282	1.495943542	0.134668368	0.1701917
CTCACGACAAGA _A_Concatenation GAGATTGTGTCC _B	1342.98382	5.14370171	0.350586819	14.67169165	9.79E-49	3.95E-47
							CTCAGCGATATA _A_Concatenation ACTTGATGGTTT _B	2788.747391	2.628395138	0.338157994	7.772683719	7.68E-15	3.67E-14
CTCAGCGATATA _A_Concatenation AGAGTGCGCTCT _B	11567.21068	2.819340595	0.416066622	6.776175841	1.23E-11	4.62E-11
							CTCAGCGATATA _A_Concatenation ATAACTCCACGC _B	1817.295306	-1.203752825	0.493744811	-2.438006027	0.014768528	0.021743588
CTCAGCGATATA _A_Concatenation ATGACCCCTTGT _B	2255.304424	0.644185286	0.662157851	0.972857584	0.330624089	0.385164718
							CTCAGCGATATA _A_Concatenation CTACGTGGCCCC _B	2374.13525	0.237574093	0.392847196	0.604749366	0.545345542	0.594691174
CTCAGCGATATA _A_Concatenation GAGATTGTGTCC _B	4171.555389	-1.558281739	0.226563311	-6.87790858	6.07E-12	2.31E-11
							CTCCATTAATGA _A_Concatenation ACTTGATGGTTT _B	10343.15364	-1.536355055	0.191592886	-8.018852292	1.07E-15	5.38E-15
CTCCATTAATGA _A_Concatenation AGAGTGCGCTCT _B	5399.455078	-1.490845992	0.220464101	-6.762307272	1.36E-11	5.04E-11
							CTCCATTAATGA _A_Concatenation ATAACTCCACGC _B	6252.989448	1.865511556	0.304377256	6.128945309	8.85E-10	2.84E-09
CTCCATTAATGA _A_Concatenation ATGACCCCTTGT _B	564.3668627	0.458413688	0.883539221	0.518837962	0.603873743	0.647047118
							CTCCATTAATGA _A_Concatenation CTACGTGGCCCC _B	6784.624693	-0.348081573	0.224431412	-1.550948551	0.120914014	0.154479216
CTCCATTAATGA _A_Concatenation GAGATTGTGTCC _B	5309.513453	0.372147324	0.33420378	1.113534154	0.265479088	0.317002098
							CTCGCACCGAGG _A_Concatenation ACTTGATGGTTT _B	9109.229052	-2.145597155	0.200223369	-10.71601765	8.56E-27	1.08E-25
CTCGCACCGAGG _A_Concatenation AGAGTGCGCTCT _B	8108.284261	-2.084395884	0.239785435	-8.692754369	3.54E-18	2.19E-17
							CTCGCACCGAGG _A_Concatenation ATAACTCCACGC _B	14278.85438	-1.265497881	0.132138307	-9.577070461	9.98E-22	8.58E-21
CTCGCACCGAGG _A_Concatenation ATGACCCCTTGT _B	2109.25225	-0.937628791	0.5936616	-1.579399428	0.114244468	0.146921654
							CTCGCACCGAGG _A_Concatenation CTACGTGGCCCC _B	8371.120298	-0.763457493	0.248207208	-3.075887677	0.002098769	0.003393445
CTCGCACCGAGG _A_Concatenation GAGATTGTGTCC _B	11869.26941	-1.878171316	0.179813271	-10.44512067	1.54E-25	1.77E-24
							CTCGTTATGGCA _A_Concatenation ACTTGATGGTTT _B	13379.89754	2.338265161	0.33631153	6.952676183	3.58E-12	1.38E-11
CTCGTTATGGCA _A_Concatenation AGAGTGCGCTCT _B	22164.57054	-1.335231707	0.071646755	-18.63631792	1.63E-77	1.91E-75
							CTCGTTATGGCA _A_Concatenation ATAACTCCACGC _B	7477.211868	4.108411187	0.732055016	5.612161786	2.00E-08	5.61E-08
CTCGTTATGGCA _A_Concatenation ATGACCCCTTGT _B	2978.925046	0.087177747	0.598411611	0.145681912	0.884172501	0.901131346
							CTCGTTATGGCA _A_Concatenation CTACGTGGCCCC _B	10865.87408	1.089079629	0.170947862	6.370829176	1.88E-10	6.39E-10
CTCGTTATGGCA _A_Concatenation GAGATTGTGTCC _B	9939.231949	2.433673767	0.332725829	7.314351806	2.59E-13	1.09E-12
							CTGCCGGTTGCG _A_Concatenation ACTTGATGGTTT _B	2116.823763	-1.419560262	0.399411133	-3.554132931	0.000379227	0.000689451
CTGCCGGTTGCG _A_Concatenation AGAGTGCGCTCT _B	1268.373288	0.008975367	0.59913725	0.014980485	0.988047749	0.98902379
							CTGCCGGTTGCG _A_Concatenation ATAACTCCACGC _B	1674.771176	-0.455347032	0.292928613	-1.554464166	0.120073738	0.153573522
CTGCCGGTTGCG _A_Concatenation ATGACCCCTTGT _B	7237.238196	0.045746629	0.675071288	0.067765626	0.945972207	0.955783501
							CTGCCGGTTGCG _A_Concatenation CTACGTGGCCCC _B	1825.147016	-0.670191524	0.206441473	-3.246399649	0.001168746	0.002000387
CTGCCGGTTGCG _A_Concatenation GAGATTGTGTCC _B	1348.103589	-0.124497455	0.636114377	-0.195715518	0.844832837	0.869374636
							CTGGTAGTTGTT _A_Concatenation ACTTGATGGTTT _B	20496.52659	-1.922070949	0.184084232	-10.44125796	1.61E-25	1.82E-24
CTGGTAGTTGTT _A_Concatenation AGAGTGCGCTCT _B	18227.85153	-2.052838972	0.111296972	-18.4446974	5.75E-76	5.60E-74
							CTGGTAGTTGTT _A_Concatenation ATAACTCCACGC _B	19402.86345	-0.721009974	0.146392835	-4.925172558	8.43E-07	2.00E-06
CTGGTAGTTGTT _A_Concatenation ATGACCCCTTGT _B	2795.615337	-0.236062309	0.453140914	-0.520946799	0.602403833	0.646064294
							CTGGTAGTTGTT _A_Concatenation CTACGTGGCCCC _B	18345.75204	-1.220000705	0.206146695	-5.918119165	3.26E-09	9.79E-09
CTGGTAGTTGTT _A_Concatenation GAGATTGTGTCC _B	34006.24859	-1.317749147	0.099837792	-13.19890108	8.90E-40	2.12E-38
							EPICXV.47-A\u splice_ ACTTGATGGTTT _b	3370.110148	1.522363448	0.352974749	4.312952846	1.61E-05	3.33E-05
EPICXV.47-A\u splice_ AGAGTGCGCTCT _b	7256.173245	-0.453222459	0.249387941	-1.817339113	0.069165204	0.09220222
							EPICXV.47-A\u splice_ ATAACTCCACGC _b	1219.294049	0.248513604	0.658994108	0.377110511	0.706091481	0.743622469
EPICXV.47-A\u splice_ ATGACCCCTTGT _b	131.4668592	4.428082018	1.333109449	3.321619257	0.000894967	0.001554557
							EPICXV.47-A\u splice_ CTACGTGGCCCC _b	1341.717945	2.770964438	0.566320975	4.892922139	9.93E-07	2.34E-06
EPICXV.47-A\u splice_ GAGATTGTGTCC _b	529.1405845	0.210914372	0.689788465	0.305766743	0.759782252	0.792315301
							GACTGTGGGCGG _A_Concatenation ACTTGATGGTTT _B	10126.88727	-1.334994621	0.23778751	-5.614233571	1.97E-08	5.56E-08
GACTGTGGGCGG _A_Concatenation AGAGTGCGCTCT _B	7684.439835	-1.434278817	0.165398846	-8.671637361	4.26E-18	2.62E-17
							GACTGTGGGCGG _A_Concatenation ATAACTCCACGC _B	11520.48725	-1.662130684	0.092569715	-17.95544781	4.35E-72	3.91E-70
GACTGTGGGCGG _A_Concatenation ATGACCCCTTGT _B	1514.374437	-1.725293087	0.47455095	-3.635632989	0.000277299	0.000510492
							GACTGTGGGCGG _A_Concatenation CTACGTGGCCCC _B	13332.76266	-1.807085252	0.217507876	-8.308137109	9.72E-17	5.34E-16
GACTGTGGGCGG _A_Concatenation GAGATTGTGTCC _B	11917.31455	-1.112830768	0.1975679	-5.632649682	1.77E-08	5.01E-08
							GAGACAGCTCTC _A_Concatenation ACTTGATGGTTT _B	5809.274672	-1.007916626	0.310419338	-3.246951799	0.001166481	0.001999438
GAGACAGCTCTC _A_Concatenation AGAGTGCGCTCT _B	6879.124207	-1.695999894	0.253139974	-6.699850162	2.09E-11	7.67E-11
							GAGACAGCTCTC _A_Concatenation ATAACTCCACGC _B	6869.928675	-2.045937039	0.277694274	-7.367588149	1.74E-13	7.41E-13
GAGACAGCTCTC _A_Concatenation ATGACCCCTTGT _B	3300.979054	-1.023436666	0.456447308	-2.242179213	0.024949792	0.035612096
							GAGACAGCTCTC _A_Concatenation CTACGTGGCCCC _B	14935.04721	-1.638631431	0.232499192	-7.047901623	1.82E-12	7.15E-12
GAGACAGCTCTC _A_Concatenation GAGATTGTGTCC _B	7190.891971	-1.525652825	0.204313542	-7.467213448	8.19E-14	3.60E-13
							GAGATTGTGTCC _A_Concatenation AAAACAAGCATT _B	5336.675738	0.40421582	0.384851971	1.050315059	0.293573284	0.345606413
GAGATTGTGTCC _A_Concatenation AAACTTTGAGCG _B	1459.363758	3.274600662	1.024407121	3.196581316	0.001390666	0.002329067
							GAGATTGTGTCC _A_Concatenation AAGACCGGTGCC _B	4279.774372	2.851095796	0.411488986	6.928729305	4.25E-12	1.62E-11
GAGATTGTGTCC _A_Concatenation AAGCAACGATAT _B	9687.727397	-0.732791936	0.179614257	-4.079809421	4.51E-05	8.87E-05
							GAGATTGTGTCC _A_Concatenation AAGGGTAAATTG _B	5539.172828	0.784199956	0.247823194	3.16435255	0.001554284	0.002577245
GAGATTGTGTCC _A_Concatenation AATCAACGAGCA _B	2866.516386	2.370936903	0.741661122	3.196792759	0.001389647	0.002329067
							GAGATTGTGTCC _A_Concatenation AATCGAGACCAG _B	2471.244011	0.631123237	0.19546636	3.228807434	0.001243076	0.002118302
GAGATTGTGTCC _A_Concatenation AATCGATCCTAC _B	7735.003056	0.436237925	0.300115623	1.453566195	0.146066615	0.182817851
							GAGATTGTGTCC _A_Concatenation AATGGCACTAGC _B	12169.38318	0.290513971	0.197503802	1.470928498	0.141310455	0.177625722
GAGATTGTGTCC _A_Concatenation ACAACGTGCATA _B	1816.591048	2.051709993	0.777095393	2.640229257	0.008284996	0.012610886
							GAGATTGTGTCC _A_Concatenation ACCAGTATTTAA _B	2318.362759	2.530517049	0.306607549	8.253277041	1.54E-16	8.34E-16
GAGATTGTGTCC _A_Concatenation ACGACTCACCGC _B	2177.911514	0.385890205	0.653687308	0.590328435	0.55497048	0.604190777
							GAGATTGTGTCC _A_Concatenation ACGGCGTAAGTA _B	1502.255208	-0.869935424	0.468775919	-1.855759624	0.063487828	0.085209266
GAGATTGTGTCC _A_Concatenation ACTCGTGTTGTC _B	6640.265781	0.10117339	0.207713557	0.487081306	0.626200714	0.666692745
							GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B	4095.253834	1.338298146	0.26750419	5.00290536	5.65E-07	1.36E-06
GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B	2062.528412	2.117670792	0.423619812	4.99898903	5.76E-07	1.39E-06
							GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B	4095.253834	1.338298146	0.26750419	5.00290536	5.65E-07	1.36E-06
GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B	2062.528412	2.117670792	0.423619812	4.99898903	5.76E-07	1.39E-06
							GAGATTGTGTCC _A_Concatenation ACTTTAGTAACA _B	1655.016432	1.199127769	1.052733662	1.139060916	0.254677747	0.30597974
GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B	6624.693834	1.33366152	0.404396008	3.297909704	0.000974075	0.001679488
							GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B	10297.21521	2.082788864	0.238568438	8.730362149	2.54E-18	1.60E-17
GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B	6624.693834	1.33366152	0.404396008	3.297909704	0.000974075	0.001679488
							GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B	10297.21521	2.082788864	0.238568438	8.730362149	2.54E-18	1.60E-17
GAGATTGTGTCC _A_Concatenation AGCCAGGTCACC _B	244.4812552	0.441155599	2.01336616	0.219113447	0.826561676	0.853578268
							GAGATTGTGTCC _A_Concatenation AGCCATAAACCT _B	7882.770077	2.682125058	0.394753816	6.79442465	1.09E-11	4.09E-11
GAGATTGTGTCC _A_Concatenation AGCCGTGCTTGA _B	6566.441048	2.21670191	0.223560652	9.915438572	3.57E-23	3.34E-22
							GAGATTGTGTCC _A_Concatenation AGGCTTCCCGCT _B	8692.300135	-1.319663199	0.192277876	-6.863312746	6.73E-12	2.55E-11
GAGATTGTGTCC _A_Concatenation AGTTAGGCTCTT _B	4833.494264	3.053940999	0.684388252	4.462293135	8.11E-06	1.74E-05
							GAGATTGTGTCC _A_Concatenation AGTTGCTTTGCT _B	12057.46837	-1.812094514	0.181276682	-9.996291282	1.58E-23	1.52E-22
GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B	662.3080557	9.181911569	1.246691289	7.365024247	1.77E-13	7.53E-13
							GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B	2560.862639	0.033208854	0.433176783	0.076663513	0.938891232	0.950271731
GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B	662.3080557	9.181911569	1.246691289	7.365024247	1.77E-13	7.53E-13
							GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B	2560.862639	0.033208854	0.433176783	0.076663513	0.938891232	0.950271731
GAGATTGTGTCC _A_Concatenation ATCCAATCTGTG _B	807.2746093	3.507832961	1.287492344	2.724546655	0.006438983	0.009943423
							GAGATTGTGTCC _A_Concatenation ATCTCTCAGTTC _B	6245.453834	3.072569727	0.669890927	4.586671656	4.50E-06	1.01E-05
GAGATTGTGTCC _A_Concatenation ATGACAAAACGA _B	6512.791531	2.46608327	0.581322977	4.24219129	2.21E-05	4.47E-05
							GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B	808.5837658	0.759510522	0.837274784	0.907122173	0.364342194	0.418555889
GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B	574.4835973	1.901952006	0.420635581	4.521614649	6.14E-06	1.34E-05
							GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B	808.5837658	0.759510522	0.837274784	0.907122173	0.364342194	0.418555889
GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B	574.4835973	1.901952006	0.420635581	4.521614649	6.14E-06	1.34E-05
							GAGATTGTGTCC _A_Concatenation ATGTGGCACGAC _B	12919.07171	1.774827467	0.122101684	14.53565106	7.20E-48	2.63E-46
GAGATTGTGTCC _A_Concatenation ATTGTATCTAAC _B	11238.66518	2.430304942	0.211274208	11.5030839	1.27E-30	2.01E-29
							GAGATTGTGTCC _A_Concatenation ATTTGTAGACCG _B	12084.65494	2.234113777	0.293388344	7.614868899	2.64E-14	1.21E-13
GAGATTGTGTCC _A_Concatenation CAACGCATGCCT _B	32322.32251	-1.668511748	0.101017217	-16.51710265	2.76E-61	1.62E-59
							GAGATTGTGTCC _A_Concatenation CACACCCGGCAG _B	6846.836394	1.978083324	0.383232672	5.161572771	2.45E-07	6.18E-07
GAGATTGTGTCC _A_Concatenation CAGTGACATAGT _B	20915.68626	2.199746831	0.195892237	11.22937216	2.93E-29	4.22E-28
							GAGATTGTGTCC _A_Concatenation CATCTCACCTAG _B	3917.193211	1.824174603	0.670392345	2.721055237	0.006507389	0.010035801
GAGATTGTGTCC _A_Concatenation CATCTGAGTCGT _B	3.550869394	-0.899600572	0.672273122	-1.338147461	0.180848372	0.223479648
							GAGATTGTGTCC _A_Concatenation CATGCTAACACC _B	2085.124923	1.925574775	0.334277327	5.760410943	8.39E-09	2.41E-08
GAGATTGTGTCC _A_Concatenation CATTAGTCCCGC _B	1330.338417	0.718933463	0.451892924	1.590937644	0.11162361	0.143867695
							GAGATTGTGTCC _A_Concatenation CATTGTTTAAAT _B	5566.683453	1.864175902	0.347928416	5.35792943	8.42E-08	2.24E-07
GAGATTGTGTCC _A_Concatenation CCAGACGGTCTG _B	9309.548485	-1.553325001	0.150987049	-10.28780293	8.00E-25	8.35E-24
							GAGATTGTGTCC _A_Concatenation CCCCTTAGGAAT _B	1646.590941	3.114869603	0.887547862	3.509522964	0.000448911	0.000808594
GAGATTGTGTCC _A_Concatenation CCCGTAGGGGCT _B	114.324098	0.281645139	1.501960445	0.187518346	0.851254241	0.874443064
							GAGATTGTGTCC _A_Concatenation CCCTATGTTCTA _B	939.1830871	0.601977151	0.79321458	0.758908328	0.447907397	0.501536156
GAGATTGTGTCC _A_Concatenation CCCTGCCTCGGG _B	21776.99227	-2.189884868	0.134972243	-16.22470536	3.37E-59	1.79E-57
							GAGATTGTGTCC _A_Concatenation CCGCCCTTATGT _B	2219.489338	2.34397758	0.545325538	4.298308843	1.72E-05	3.52E-05
GAGATTGTGTCC _A_Concatenation CCTAAATGCAAG _B	9186.061817	-0.501834755	0.275741955	-1.819943416	0.068767622	0.091978662
							GAGATTGTGTCC _A_Concatenation CGATGGCGGAAT _B	14164.33153	-1.334820415	0.278967887	-4.784853296	1.71E-06	3.95E-06
GAGATTGTGTCC _A_Concatenation CGCCGGCATACA _B	3010.214688	1.447480652	0.325147731	4.451763036	8.52E-06	1.82E-05
							GAGATTGTGTCC _A_Concatenation CGGCAATTGCTT _B	7661.268671	-1.242791132	0.245722055	-5.057710962	4.24E-07	1.05E-06
GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B	0.057653027	-1.291685486	2.119037916	-0.609562234	0.542151835	0.592867629
							GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B	1730.527538	1.039453407	0.792476787	1.31165155	0.189637731	0.232863979
GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B	0.057653027	-1.291685486	2.119037916	-0.609562234	0.542151835	0.592867629
							GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B	1730.527538	1.039453407	0.792476787	1.31165155	0.189637731	0.232863979
GAGATTGTGTCC _A_Concatenation CTCACGACAAGA _B	1712.701439	1.628481425	0.516733271	3.151493269	0.001624379	0.002685854
							GAGATTGTGTCC _A_Concatenation CTCAGCGATATA _B	3342.705632	-0.849998546	0.511575254	-1.661531787	0.09660669	0.126464973
GAGATTGTGTCC _A_Concatenation CTCCATTAATGA _B	18014.6158	-0.801891214	0.08515548	-9.416789284	4.65E-21	3.65E-20
							GAGATTGTGTCC _A_Concatenation CTCGCACCGAGG _B	17528.86335	-0.699910187	0.142989767	-4.894827104	9.84E-07	2.32E-06
GAGATTGTGTCC _A_Concatenation CTCGTTATGGCA _B	8403.138644	2.491850706	0.416343169	5.985088479	2.16E-09	6.71E-09
							GAGATTGTGTCC _A_Concatenation CTGCCGGTTGCG _B	3604.594588	-0.040901727	0.308803908	-0.132452104	0.894626705	0.910007777
GAGATTGTGTCC _A_Concatenation CTGGTAGTTGTT _B	26536.15736	-0.584990614	0.128042923	-4.56870711	4.91E-06	1.09E-05
							GAGATTGTGTCC _A_Concatenation EPICXV.47_B	1904.677425	-1.066978728	0.919621999	-1.160236193	0.245952655	0.297330562
GAGATTGTGTCC _A_Concatenation GACTGTGGGCGG _B	4126.808083	-0.476568317	0.262239943	-1.817298737	0.069171383	0.09220222
							GAGATTGTGTCC _A_Concatenation GAGACAGCTCTC _B	34038.5331	-3.965311735	0.423368572	-9.36609848	7.53E-21	5.80E-20
GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B	2980.186823	0.589599728	0.637115163	0.925420963	0.354746979	0.41018716
							GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B	1929.576791	0.327021536	0.657788863	0.497152741	0.619081345	0.660918806
GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B	2980.186823	0.589599728	0.637115163	0.925420963	0.354746979	0.41018716
							GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B	1929.576791	0.327021536	0.657788863	0.497152741	0.619081345	0.660918806
GAGATTGTGTCC _A_Concatenation GAGTGACCTATT _B	29879.64409	-1.696783117	0.101623892	-16.69669485	1.39E-62	9.00E-61
							GAGATTGTGTCC _A_Concatenation GATCGCATGTTC _B	8667.101634	-0.116139831	0.238166236	-0.48764188	0.625803526	0.666692745
GAGATTGTGTCC _A_Concatenation GATGGAGCTACA _B	1727.264409	0.744281536	0.314497427	2.366574325	0.017953569	0.026104132
							GAGATTGTGTCC _A_Concatenation GCAACGAGGGTC _B	2910.042837	2.498823405	0.589846464	4.236396344	2.27E-05	4.58E-05
GAGATTGTGTCC _A_Concatenation GCAGATTCGAAT _B	9927.659867	-1.511057001	0.139599281	-10.82424629	2.64E-27	3.43E-26
							GAGATTGTGTCC _A_Concatenation GCGAGGCAGACC _B	5389.369696	-0.803765379	0.317934658	-2.528083549	0.011468706	0.017074953
GAGATTGTGTCC _A_Concatenation GGAGGCACATCG _B	11011.52144	-1.926106727	0.580243561	-3.319479711	0.000901854	0.001561877
							GAGATTGTGTCC _A_Concatenation GGCACAGCTCCA _B	18723.48113	0.766734611	0.308720878	2.483585226	0.013006721	0.019271047
GAGATTGTGTCC _A_Concatenation GGCACTGTCGAG _B	6256.479428	1.107213689	0.438029097	2.527717215	0.011480678	0.017074953
							GAGATTGTGTCC _A_Concatenation GGCCTTTCGGGC _B	0
GAGATTGTGTCC _A_Concatenation GGGAGTATGTCG _B	7172.554958	-1.076649573	0.152398239	-7.064711364	1.61E-12	6.36E-12
							GAGATTGTGTCC _A_Concatenation GGTGTCTCGATT _B	3242.926378	-1.276083839	0.674481515	-1.89194783	0.058497932	0.078965453
GAGATTGTGTCC _A_Concatenation GTACATACCGAA _B	3800.126493	1.382760014	0.31239479	4.426322267	9.59E-06	2.04E-05
							GAGATTGTGTCC _A_Concatenation GTCACCCTCCTT _B	0
GAGATTGTGTCC _A_Concatenation GTTCCACGCCTG _B	5370.214087	3.661429717	0.547584871	6.686506344	2.29E-11	8.35E-11
							GAGATTGTGTCC _A_Concatenation Stop_1_B	2185.779945	2.004603591	0.467876258	4.28447385	1.83E-05	3.73E-05
GAGATTGTGTCC _A_Concatenation Stop_2_B	588.0161036	3.23800693	0.924983126	3.50061189	0.000464191	0.000832269
							GAGATTGTGTCC _A_Concatenation TAAAATTTATCA _B	3292.626297	2.46324368	0.498016272	4.946110834	7.57E-07	1.80E-06
GAGATTGTGTCC _A_Concatenation TAAGATTCAACG _B	2214.537491	3.701330118	1.518623491	2.437292811	0.014797692	0.021759121
							GAGATTGTGTCC _A_Concatenation TACATGAGGCAC _B	10300.46707	-0.506762525	0.182672861	-2.774153329	0.005534559	0.008558067
GAGATTGTGTCC _A_Concatenation TACTTCTAGCGG _B	2633.119212	3.23757946	1.044560922	3.099464466	0.001938708	0.003152086
							GAGATTGTGTCC _A_Concatenation TATCGCAAGAAC _B	8427.543488	-1.042180713	0.227350372	-4.584029057	4.56E-06	1.02E-05
GAGATTGTGTCC _A_Concatenation TATCTATCGTGT _B	681.5148978	-3.253391393	0.923010978	-3.524759155	0.000423868	0.000765845
							GAGATTGTGTCC _A_Concatenation TATTAAAAGTGC _B	6420.025151	-2.017700031	0.371097623	-5.437113863	5.42E-08	1.47E-07
GAGATTGTGTCC _A_Concatenation TCAGCCGTAGGC _B	15038.04828	0.571697876	0.245394253	2.329711759	0.019821391	0.028677235
							GAGATTGTGTCC _A_Concatenation TCTATCACAACT _B	305.4227279	7.245923899	0.846358948	8.561289414	1.12E-17	6.69E-17
GAGATTGTGTCC _A_Concatenation TCTGTACCAACG _B	11200.34075	1.762086203	0.402249802	4.380576933	1.18E-05	2.48E-05
							GAGATTGTGTCC _A_Concatenation TCTTAGAGGGTG _B	4569.884844	2.022091562	0.503627264	4.015055794	5.94E-05	0.00011618
GAGATTGTGTCC _A_Concatenation TCTTGGTTTTGA _B	11834.91456	1.984629396	0.117081562	16.95082781	1.90E-64	1.39E-62
							GAGATTGTGTCC _A_Concatenation TGATGAGCGCCC _B	21750.91788	1.713243827	0.223476867	7.666313964	1.77E-14	8.28E-14
GAGATTGTGTCC _A_Concatenation TGCCAGACGGTC _B	5098.935443	1.602001775	0.404186805	3.963518243	7.39E-05	0.000142466
							GAGATTGTGTCC _A_Concatenation TGGCCCCCAGTT _B	9713.291081	-1.717455543	0.237420085	-7.233825816	4.70E-13	1.94E-12
GAGATTGTGTCC _A_Concatenation TTAAATGAGGGC _B	6260.971569	-1.01361349	0.201210809	-5.037569767	4.71E-07	1.16E-06
							GAGATTGTGTCC _A_Concatenation TTAGTGCCATAC _B	0
GAGATTGTGTCC _A_Concatenation TTCTAATTTCCT _B	3938.013777	0.939190431	0.270525188	3.471730069	0.000517116	0.000921507
							GAGATTGTGTCC _A_Concatenation TTTAACGGATTG _B	8439.47047	1.401241181	0.327326145	4.280871554	1.86E-05	3.78E-05
GAGATTGTGTCC _A_Concatenation Joint_ 1_B	7033.564145	1.60921915	0.407312008	3.950826682	7.79E-05	0.000149497
							GAGATTGTGTCC _A_Concatenation Joint_ 2_B	13580.00704	-0.191414085	0.182603324	-1.048250824	0.29452306	0.346375711
GAGATTGTGTCC _A_Concatenation Joint_ 3_B	20988.50251	-0.968619845	0.145282366	-6.667153568	2.61E-11	9.44E-11
							GAGTGACCTATT _A_Concatenation ACTTGATGGTTT _B	4697.773394	-1.784620704	0.299626504	-5.956151004	2.58E-09	7.92E-09
GAGTGACCTATT _A_Concatenation AGAGTGCGCTCT _B	2203.003598	-0.004534526	0.37040494	-0.012242079	0.990232478	0.990232478
							GAGTGACCTATT _A_Concatenation ATAACTCCACGC _B	4738.45974	-1.653219507	0.251002117	-6.586476357	4.50E-11	1.61E-10
GAGTGACCTATT _A_Concatenation ATGACCCCTTGT _B	210.4204591	0.520192554	1.091455008	0.47660467	0.633643657	0.673390396
							GAGTGACCTATT _A_Concatenation CTACGTGGCCCC _B	4904.828969	-1.407171281	0.242143112	-5.811320696	6.20E-09	1.80E-08
GAGTGACCTATT _A_Concatenation GAGATTGTGTCC _B	3175.115736	-0.890295066	0.457619496	-1.945491994	0.051715792	0.070297397
							GATCGCATGTTC _A_Concatenation ACTTGATGGTTT _B	21926.63182	-1.1643545	0.123435064	-9.432931489	3.99E-21	3.15E-20
GATCGCATGTTC _A_Concatenation AGAGTGCGCTCT _B	17309.22293	-1.202089842	0.194290174	-6.187085095	6.13E-10	2.02E-09
							GATCGCATGTTC _A_Concatenation ATAACTCCACGC _B	9774.241692	1.822935539	0.285335583	6.388742409	1.67E-10	5.70E-10
GATCGCATGTTC _A_Concatenation ATGACCCCTTGT _B	1303.120528	-0.120356953	0.310037765	-0.388200945	0.697867334	0.735623908
							GATCGCATGTTC _A_Concatenation CTACGTGGCCCC _B	14679.17258	-0.674627074	0.215892587	-3.124827417	0.001779094	0.002908757
GATCGCATGTTC _A_Concatenation GAGATTGTGTCC _B	16097.81153	0.046021931	0.156391263	0.294274312	0.7685483	0.799317582
							GATGGAGCTACA _A_Concatenation ACTTGATGGTTT _B	4553.568887	2.195814037	0.233215443	9.415388661	4.71E-21	3.67E-20
GATGGAGCTACA _A_Concatenation AGAGTGCGCTCT _B	8291.856374	-0.948994035	0.169952594	-5.583874967	2.35E-08	6.58E-08
							GATGGAGCTACA _A_Concatenation ATAACTCCACGC _B	2064.702728	3.854252837	0.756647404	5.09385589	3.51E-07	8.73E-07
GATGGAGCTACA _A_Concatenation ATGACCCCTTGT _B	827.6917824	-1.444321425	0.875735192	-1.64926731	0.099092884	0.129285247
							GATGGAGCTACA _A_Concatenation CTACGTGGCCCC _B	1274.880764	0.799181055	0.724730237	1.102729008	0.270144866	0.322244233
GATGGAGCTACA _A_Concatenation GAGATTGTGTCC _B	708.2943437	0.919186736	0.751331732	1.223409976	0.221174887	0.26848748
							GCAACGAGGGTC _A_Concatenation ACTTGATGGTTT _B	13269.23238	2.211123582	0.324280159	6.818559566	9.20E-12	3.47E-11
GCAACGAGGGTC _A_Concatenation AGAGTGCGCTCT _B	20365.77872	-0.917134773	0.144835344	-6.332258048	2.42E-10	8.16E-10
							GCAACGAGGGTC _A_Concatenation ATAACTCCACGC _B	4475.965961	-0.037496669	0.284700847	-0.131705505	0.895217231	0.910007777
GCAACGAGGGTC _A_Concatenation ATGACCCCTTGT _B	1475.282763	1.452162	0.585303114	2.48104267	0.013099869	0.01938449
							GCAACGAGGGTC _A_Concatenation CTACGTGGCCCC _B	4202.603619	3.814915033	0.309101227	12.34196019	5.38E-35	1.01E-33
GCAACGAGGGTC _A_Concatenation GAGATTGTGTCC _B	8053.304043	1.747967233	0.227510524	7.683017043	1.55E-14	7.29E-14
							GCAGATTCGAAT _A_Concatenation ACTTGATGGTTT _B	1681.303554	-1.929604695	0.213270677	-9.04767933	1.46E-19	1.00E-18
GCAGATTCGAAT _A_Concatenation AGAGTGCGCTCT _B	1005.136945	-0.722559377	0.413449554	-1.747636126	0.080527056	0.106248452
							GCAGATTCGAAT _A_Concatenation ATAACTCCACGC _B	2415.102403	-1.583046187	0.292496086	-5.412196129	6.23E-08	1.68E-07
GCAGATTCGAAT _A_Concatenation ATGACCCCTTGT _B	2008.675555	-1.374543042	0.300679732	-4.571452261	4.84E-06	1.08E-05
							GCAGATTCGAAT _A_Concatenation CTACGTGGCCCC _B	2163.854106	-1.207765506	0.346727309	-3.483329621	0.000495218	0.000885184
GCAGATTCGAAT _A_Concatenation GAGATTGTGTCC _B	3134.395892	-1.932223915	0.121062901	-15.96049576	2.41E-57	1.22E-55
							GCGAGGCAGACC _A_Concatenation ACTTGATGGTTT _B	9998.460602	-1.608929324	0.270077497	-5.957287597	2.56E-09	7.89E-09
GCGAGGCAGACC _A_Concatenation AGAGTGCGCTCT _B	10229.28468	-0.41378564	0.281685872	-1.468961285	0.14184329	0.177912882
							GCGAGGCAGACC _A_Concatenation ATAACTCCACGC _B	7481.38397	0.984753459	0.17775046	5.540089516	3.02E-08	8.35E-08
GCGAGGCAGACC _A_Concatenation ATGACCCCTTGT _B	2947.323423	-0.581244666	0.550826388	-1.055222987	0.291323353	0.343649849
							GCGAGGCAGACC _A_Concatenation CTACGTGGCCCC _B	13945.66307	-0.657090684	0.229655841	-2.861197353	0.004220442	0.006604682
GCGAGGCAGACC _A_Concatenation GAGATTGTGTCC _B	13856.50588	-1.089375366	0.133772988	-8.143462896	3.84E-16	2.00E-15
							GGAGGCACATCG _A_Concatenation ACTTGATGGTTT _B	10911.17753	0.130262569	0.683996076	0.190443445	0.848961656	0.872855036
GGAGGCACATCG _A_Concatenation AGAGTGCGCTCT _B	10449.92639	-1.247434251	0.169311162	-7.367702399	1.74E-13	7.41E-13
							GGAGGCACATCG _A_Concatenation ATAACTCCACGC _B	1820.823073	1.000313211	0.288305058	3.469634627	0.000521167	0.000927312
GGAGGCACATCG _A_Concatenation ATGACCCCTTGT _B	736.3850518	1.665678435	1.488224186	1.119238923	0.263038224	0.314730486
							GGAGGCACATCG _A_Concatenation CTACGTGGCCCC _B	2577.387099	-0.246567613	0.577620977	-0.426867484	0.66947585	0.706971336
GGAGGCACATCG _A_Concatenation GAGATTGTGTCC _B	2408.376071	0.171544071	0.342882893	0.500299299	0.616864348	0.660303913
							GGCACAGCTCCA _A_Concatenation ACTTGATGGTTT _B	10168.40188	1.82754345	0.300879549	6.074003564	1.25E-09	3.92E-09
GGCACAGCTCCA _A_Concatenation AGAGTGCGCTCT _B	13809.01054	-1.319436508	0.128819826	-10.24249569	1.28E-24	1.30E-23
							GGCACAGCTCCA _A_Concatenation ATAACTCCACGC _B	3891.890595	0.875741323	0.439679875	1.991770316	0.046396265	0.063733529
GGCACAGCTCCA _A_Concatenation ATGACCCCTTGT _B	665.7482723	2.529857075	1.170407546	2.161518083	0.030655342	0.043072229
							GGCACAGCTCCA _A_Concatenation CTACGTGGCCCC _B	4210.973173	2.255188415	0.475051927	4.747246121	2.06E-06	4.71E-06
GGCACAGCTCCA _A_Concatenation GAGATTGTGTCC _B	7092.482291	0.309945391	0.203026896	1.526622322	0.126854953	0.161384458
							GGCACTGTCGAG _A_Concatenation ACTTGATGGTTT _B	26937.44905	-0.484092301	0.145936065	-3.317153301	0.000909397	0.001572611
GGCACTGTCGAG _A_Concatenation AGAGTGCGCTCT _B	22237.80463	-1.634076587	0.168257112	-9.711783167	2.69E-22	2.38E-21
							GGCACTGTCGAG _A_Concatenation ATAACTCCACGC _B	6876.088123	1.567885594	0.515860392	3.039360297	0.002370811	0.003806976
GGCACTGTCGAG _A_Concatenation ATGACCCCTTGT _B	5560.317685	-0.602936851	0.195686234	-3.081140856	0.002062091	0.003338759
							GGCACTGTCGAG _A_Concatenation CTACGTGGCCCC _B	12239.14756	1.735512855	0.297827413	5.827243501	5.64E-09	1.65E-08
GGCACTGTCGAG _A_Concatenation GAGATTGTGTCC _B	15495.60877	0.447924345	0.198725186	2.253988807	0.024196872	0.034579638
							GGCCTTTCGGGC _A_Concatenation ACTTGATGGTTT _B	12622.87776	-1.370937157	0.225191372	-6.087876027	1.14E-09	3.62E-09
GGCCTTTCGGGC _A_Concatenation AGAGTGCGCTCT _B	10465.7957	-1.517975013	0.301138982	-5.040778848	4.64E-07	1.14E-06
							GGCCTTTCGGGC _A_Concatenation ATAACTCCACGC _B	11042.17768	0.699486794	0.228048976	3.067265671	0.002160268	0.003478447
GGCCTTTCGGGC _A_Concatenation ATGACCCCTTGT _B	5341.830827	-1.033980621	0.22857522	-4.523590171	6.08E-06	1.33E-05
							GGCCTTTCGGGC _A_Concatenation CTACGTGGCCCC _B	13022.28958	-0.344613453	0.167997564	-2.051300298	0.040237712	0.055666136
GGCCTTTCGGGC _A_Concatenation GAGATTGTGTCC _B	15749.77559	-0.902085088	0.152874766	-5.90081093	3.62E-09	1.08E-08
							GGGAGTATGTCG _A_Concatenation ACTTGATGGTTT _B	5734.817642	-0.44540666	0.281682904	-1.581234267	0.113824483	0.146542754
GGGAGTATGTCG _A_Concatenation AGAGTGCGCTCT _B	5406.206268	-1.400220305	0.259292108	-5.400165543	6.66E-08	1.79E-07
							GGGAGTATGTCG _A_Concatenation ATAACTCCACGC _B	8760.106862	-1.501784784	0.227146455	-6.611526413	3.80E-11	1.37E-10
GGGAGTATGTCG _A_Concatenation ATGACCCCTTGT _B	1288.255927	1.582732061	0.398763117	3.96910344	7.21E-05	0.000140093
							GGGAGTATGTCG _A_Concatenation CTACGTGGCCCC _B	12308.85067	-1.381244589	0.183001588	-7.547719152	4.43E-14	1.98E-13
GGGAGTATGTCG _A_Concatenation GAGATTGTGTCC _B	13024.98764	-1.213572927	0.360156739	-3.369568845	0.000752859	0.001327439
							GGTGTCTCGATT _A_Concatenation ACTTGATGGTTT _B	3814.828771	1.464165491	0.336886557	4.346167748	1.39E-05	2.88E-05
GGTGTCTCGATT _A_Concatenation AGAGTGCGCTCT _B	8109.140606	-0.582246437	0.226659977	-2.568810098	0.010204836	0.015255056
							GGTGTCTCGATT _A_Concatenation ATAACTCCACGC _B	1582.26442	-0.887264559	0.382376342	-2.320396066	0.020319462	0.029325248
GGTGTCTCGATT _A_Concatenation ATGACCCCTTGT _B	660.0491018	2.02701979	0.934524351	2.169039028	0.030079721	0.042365294
							GGTGTCTCGATT _A_Concatenation CTACGTGGCCCC _B	1598.326951	1.211058913	0.42680666	2.83748832	0.004547001	0.007096721
GGTGTCTCGATT _A_Concatenation GAGATTGTGTCC _B	1317.17623	5.588341356	0.407807395	13.70338406	9.69E-43	2.85E-41
							GTACATACCGAA _A_Concatenation ACTTGATGGTTT _B	6560.157472	0.149710419	0.179329014	0.83483657	0.403809732	0.457416257
GTACATACCGAA _A_Concatenation AGAGTGCGCTCT _B	4829.016109	-0.88093024	0.14367658	-6.131341942	8.71E-10	2.81E-09
							GTACATACCGAA _A_Concatenation ATAACTCCACGC _B	1740.833154	1.160160012	0.518104636	2.239238817	0.025140381	0.035840373
GTACATACCGAA _A_Concatenation ATGACCCCTTGT _B	886.7533914	1.577162801	1.327084549	1.188441838	0.234659381	0.284266131
							GTACATACCGAA _A_Concatenation CTACGTGGCCCC _B	1434.784202	3.118197979	1.160222501	2.687586197	0.007197052	0.011026677
GTACATACCGAA _A_Concatenation GAGATTGTGTCC _B	3638.304071	2.018138714	0.435258468	4.636644341	3.54E-06	7.98E-06
							GTCACCCTCCTT _A_Concatenation ACTTGATGGTTT _B	2952.325444	3.977248973	0.587903056	6.765144236	1.33E-11	4.96E-11
GTCACCCTCCTT _A_Concatenation AGAGTGCGCTCT _B	2794.00108	-1.444032725	0.491776329	-2.936360782	0.003320878	0.00524609
							GTCACCCTCCTT _A_Concatenation ATAACTCCACGC _B	343.8542156	6.720052053	0.588537442	11.4182235	3.39E-30	5.15E-29
GTCACCCTCCTT _A_Concatenation ATGACCCCTTGT _B	58.45196938	8.365760902	1.757942818	4.758835621	1.95E-06	4.46E-06
							GTCACCCTCCTT _A_Concatenation CTACGTGGCCCC _B	976.812591	3.086674978	1.881831906	1.640250103	0.100953176	0.13156551
GTCACCCTCCTT _A_Concatenation GAGATTGTGTCC _B	427.5145602	1.539530063	1.58836413	0.969255119	0.332417916	0.386663228
							GTTCCACGCCTG _A_Concatenation ACTTGATGGTTT _B	3541.702709	2.023938089	0.414889818	4.87825442	1.07E-06	2.51E-06
GTTCCACGCCTG _A_Concatenation AGAGTGCGCTCT _B	4180.581225	-1.658960556	0.286791818	-5.784546328	7.27E-09	2.10E-08
							GTTCCACGCCTG _A_Concatenation ATAACTCCACGC _B	1642.066144	-0.381452	0.512562258	-0.744206181	0.456751749	0.5094874
GTTCCACGCCTG _A_Concatenation ATGACCCCTTGT _B	2531.307398	-1.891181968	0.241050358	-7.845588706	4.31E-15	2.09E-14
							GTTCCACGCCTG _A_Concatenation CTACGTGGCCCC _B	11395.16067	-2.639856976	0.326663242	-8.081279555	6.41E-16	3.26E-15
GTTCCACGCCTG _A_Concatenation GAGATTGTGTCC _B	3410.426437	0.806907237	0.418935973	1.926087251	0.05409348	0.073443993
							Stop-1_A/u splice_ ACTTGATGGTTT _b	6770.939871	-1.550289594	0.154376583	-10.04225878	9.94E-24	9.60E-23
Stop-1_A/u splice_ AGAGTGCGCTCT _b	3515.42995	-1.073168093	0.213288463	-5.031533723	4.87E-07	1.19E-06
							Stop-1_A/u splice_ ATAACTCCACGC _b	3762.375634	-0.058833579	0.323078612	-0.182102983	0.855501908	0.878034882
Stop-1_A/u splice_ ATGACCCCTTGT _b	5292.419803	-1.232494879	0.220901192	-5.579394429	2.41E-08	6.72E-08
							Stop-1_A/u splice_ CTACGTGGCCCC _b	4763.092809	-0.862005644	0.163658444	-5.267101534	1.39E-07	3.58E-07
Stop-1_A/u splice_ GAGATTGTGTCC _b	4167.210017	-0.845348565	0.3825702	-2.20965607	0.027129041	0.038407725
							Stop 2_A splice ACTTGATGGTTT B	4651.827038	-1.345155133	0.31788373	-4.231594783	2.32E-05	4.67E-05
Stop 2_A splice AGAGTGCGCTCT B	5491.22895	-0.209680553	0.196807086	-1.065411603	0.286689708	0.339210798
							Stop 2_A splice ATAACTCCACGC B	7206.40228	-1.432278801	0.204768335	-6.994630294	2.66E-12	1.04E-11
Stop 2_A splice ATGACCCCTTGT B	4264.663587	-1.301521091	0.228364187	-5.699322233	1.20E-08	3.42E-08
							Stop 2_A splice CTACGTGGCCCC B	8777.825472	-0.958387811	0.223296821	-4.291990402	1.77E-05	3.62E-05
Stop 2_A splice GAGATTGTGTCC B	7440.622554	-1.787105409	0.123418402	-14.48005631	1.62E-47	5.74E-46
							TAAAATTTATCA _A_Concatenation ACTTGATGGTTT _B	21275.58545	3.681447284	0.419828387	8.768933689	1.80E-18	1.14E-17
TAAAATTTATCA _A_Concatenation AGAGTGCGCTCT _B	35374.02741	-1.2744245	0.118961367	-10.71292748	8.85E-27	1.10E-25
							TAAAATTTATCA _A_Concatenation ATAACTCCACGC _B	6986.696056	2.26992008	0.463393497	4.898472018	9.66E-07	2.29E-06
TAAAATTTATCA _A_Concatenation ATGACCCCTTGT _B	1571.431201	1.152400318	0.905355488	1.272870527	0.203063989	0.24715172
							TAAAATTTATCA _A_Concatenation CTACGTGGCCCC _B	7003.422513	0.884461045	0.413024856	2.141423285	0.032239919	0.044974302
TAAAATTTATCA _A_Concatenation GAGATTGTGTCC _B	6062.194542	2.021145272	0.229834503	8.793915836	1.44E-18	9.28E-18
							TAAGATTCAACG _A_Concatenation ACTTGATGGTTT _B	6759.542322	3.512228277	0.433036603	8.110696076	5.03E-16	2.60E-15
TAAGATTCAACG _A_Concatenation AGAGTGCGCTCT _B	5395.080264	-0.985697108	0.161075465	-6.119473945	9.39E-10	3.01E-09
							TAAGATTCAACG _A_Concatenation ATAACTCCACGC _B	2099.298848	1.514948514	0.632862051	2.393805271	0.016674599	0.024304995
TAAGATTCAACG _A_Concatenation ATGACCCCTTGT _B	632.6750281	-0.220433001	0.746118033	-0.295439852	0.767657894	0.799317582
							TAAGATTCAACG _A_Concatenation CTACGTGGCCCC _B	3468.070765	1.377322426	0.38881717	3.542339516	0.000396595	0.000717677
TAAGATTCAACG _A_Concatenation GAGATTGTGTCC _B	4582.259843	1.88792703	0.433941248	4.350651241	1.36E-05	2.82E-05
							TACATGAGGCAC _A_Concatenation ACTTGATGGTTT _B	6149.76019	-1.347641882	0.154978138	-8.695690212	3.45E-18	2.14E-17
TACATGAGGCAC _A_Concatenation AGAGTGCGCTCT _B	5492.076135	-1.683303257	0.301492183	-5.583240142	2.36E-08	6.59E-08
							TACATGAGGCAC _A_Concatenation ATAACTCCACGC _B	5919.33223	1.551789521	0.16325261	9.50544997	1.99E-21	1.65E-20
TACATGAGGCAC _A_Concatenation ATGACCCCTTGT _B	1309.199585	-1.026581297	0.523263491	-1.961882137	0.049776208	0.067897768
							TACATGAGGCAC _A_Concatenation CTACGTGGCCCC _B	9934.852402	-0.76646939	0.169716852	-4.516165499	6.30E-06	1.37E-05
TACATGAGGCAC _A_Concatenation GAGATTGTGTCC _B	8728.309171	0.233306811	0.212863709	1.096038456	0.273061946	0.325060503
							TACTTCTAGCGG _A_Concatenation ACTTGATGGTTT _B	4302.117559	1.652448374	0.441083263	3.746341136	0.000179433	0.000336148
TACTTCTAGCGG _A_Concatenation AGAGTGCGCTCT _B	4475.732991	-1.667434184	0.200975338	-8.296710438	1.07E-16	5.85E-16
							TACTTCTAGCGG _A_Concatenation ATAACTCCACGC _B	477.7724878	2.437585897	1.639942812	1.486384695	0.137177396	0.173027042
TACTTCTAGCGG _A_Concatenation ATGACCCCTTGT _B	809.5944266	2.088643729	0.471961628	4.425452423	9.62E-06	2.04E-05
							TACTTCTAGCGG _A_Concatenation CTACGTGGCCCC _B	2398.191231	3.13191843	0.628499884	4.98316469	6.26E-07	1.50E-06
TACTTCTAGCGG _A_Concatenation GAGATTGTGTCC _B	2284.807319	0.044261275	0.247928202	0.178524569	0.858311028	0.880145256
							TATCGCAAGAAC _A_Concatenation ACTTGATGGTTT _B	12059.72269	-1.388513503	0.130785731	-10.61670483	2.49E-26	2.94E-25
TATCGCAAGAAC _A_Concatenation AGAGTGCGCTCT _B	15379.92089	-1.799208835	0.194469728	-9.251871009	2.21E-20	1.63E-19
							TATCGCAAGAAC _A_Concatenation ATAACTCCACGC _B	18972.64165	-1.138822259	0.107213583	-10.6219961	2.35E-26	2.81E-25
TATCGCAAGAAC _A_Concatenation ATGACCCCTTGT _B	6480.891045	-1.495319759	0.284813575	-5.25017026	1.52E-07	3.91E-07
							TATCGCAAGAAC _A_Concatenation CTACGTGGCCCC _B	16789.93099	-1.246919211	0.120838265	-10.31891023	5.79E-25	6.26E-24
TATCGCAAGAAC _A_Concatenation GAGATTGTGTCC _B	14644.22332	-0.488531461	0.057006493	-8.569751243	1.04E-17	6.25E-17
							TATCTATCGTGT _A_Concatenation ACTTGATGGTTT _B	2811.948212	2.672265841	0.593125566	4.505396487	6.62E-06	1.43E-05
TATCTATCGTGT _A_Concatenation AGAGTGCGCTCT _B	10930.15846	-0.773125124	0.099871015	-7.741236252	9.85E-15	4.66E-14
							TATCTATCGTGT _A_Concatenation ATAACTCCACGC _B	1384.03324	-2.232141475	0.538541488	-4.144790186	3.40E-05	6.77E-05
TATCTATCGTGT _A_Concatenation ATGACCCCTTGT _B	781.9986629	-0.89185393	0.400957593	-2.224309867	0.026127603	0.037111991
							TATCTATCGTGT _A_Concatenation CTACGTGGCCCC _B	14.1790172	3.494903988	1.210382028	2.887438764	0.003883922	0.006110774
TATCTATCGTGT _A_Concatenation GAGATTGTGTCC _B	269.9342778	2.758841473	1.015950257	2.715528102	0.006617016	0.010191425
							TATTAAAAGTGC _A_Concatenation ACTTGATGGTTT _B	1791.891217	-0.490610036	0.307945502	-1.593171626	0.111121695	0.143378875
TATTAAAAGTGC _A_Concatenation AGAGTGCGCTCT _B	6790.197544	-3.056231128	0.242437497	-12.60626417	1.95E-36	4.07E-35
							TATTAAAAGTGC _A_Concatenation ATAACTCCACGC _B	2098.961786	0.262924991	0.458676551	0.573225272	0.566492175	0.613743607
TATTAAAAGTGC _A_Concatenation ATGACCCCTTGT _B	1293.63795	-0.035491092	0.660966192	-0.053695776	0.957177549	0.963773087
							TATTAAAAGTGC _A_Concatenation CTACGTGGCCCC _B	6284.208552	-1.152659623	0.213556954	-5.397434272	6.76E-08	1.82E-07
TATTAAAAGTGC _A_Concatenation GAGATTGTGTCC _B	7027.473739	-2.02708462	0.219005973	-9.255841726	2.13E-20	1.58E-19
							TCAGCCGTAGGC _A_Concatenation ACTTGATGGTTT _B	16554.34192	-1.453057618	0.064022099	-22.69618844	4.89E-114	1.14E-111
TCAGCCGTAGGC _A_Concatenation AGAGTGCGCTCT _B	20248.40323	-1.988435524	0.133368132	-14.90937526	2.86E-50	1.29E-48
							TCAGCCGTAGGC _A_Concatenation ATAACTCCACGC _B	5684.077083	3.324799708	0.519910917	6.394941129	1.61E-10	5.51E-10
TCAGCCGTAGGC _A_Concatenation ATGACCCCTTGT _B	1689.960123	1.251569527	0.39928948	3.134491611	0.001721522	0.002826487
							TCAGCCGTAGGC _A_Concatenation CTACGTGGCCCC _B	11740.81276	0.12600346	0.129210924	0.97517653	0.329472702	0.384384819
TCAGCCGTAGGC _A_Concatenation GAGATTGTGTCC _B	12895.42597	0.070861143	0.127183025	0.55715881	0.57741893	0.621549474
							TCTATCACAACT _A_Concatenation ACTTGATGGTTT _B	4350.649725	4.136958603	1.244116147	3.325218962	0.000883491	0.001536907
TCTATCACAACT _A_Concatenation AGAGTGCGCTCT _B	6986.453878	-1.147688985	0.287304839	-3.994673361	6.48E-05	0.00012601
							TCTATCACAACT _A_Concatenation ATAACTCCACGC _B	1160.085311	0.483088111	1.021330534	0.472998794	0.63621404	0.675507913
TCTATCACAACT _A_Concatenation ATGACCCCTTGT _B	1327.290744	4.198515234	0.75143292	5.587345356	2.31E-08	6.46E-08
							TCTATCACAACT _A_Concatenation CTACGTGGCCCC _B	3739.709094	1.537223849	0.293426341	5.238874747	1.62E-07	4.15E-07
TCTATCACAACT _A_Concatenation GAGATTGTGTCC _B	3762.752041	-0.426854541	0.867553278	-0.492021127	0.622704409	0.664180158
							TCTGTACCAACG _A_Concatenation ACTTGATGGTTT _B	6868.114756	3.852317439	0.427231429	9.016933621	1.93E-19	1.31E-18
TCTGTACCAACG _A_Concatenation AGAGTGCGCTCT _B	17789.47762	-0.916017932	0.154156057	-5.942146884	2.81E-09	8.56E-09
							TCTGTACCAACG _A_Concatenation ATAACTCCACGC _B	305.1123518	-1.151692157	1.438008653	-0.80089376	0.423193153	0.476601923
TCTGTACCAACG _A_Concatenation ATGACCCCTTGT _B	980.9939975	-0.314616163	0.394106935	-0.798301515	0.424695539	0.477374121
							TCTGTACCAACG _A_Concatenation CTACGTGGCCCC _B	1319.119465	4.970174484	0.838038212	5.930725369	3.02E-09	9.11E-09
TCTGTACCAACG _A_Concatenation GAGATTGTGTCC _B	1905.64523	1.193588807	0.707357765	1.687390548	0.09152828	0.120220853
							TCTTAGAGGGTG _A_Concatenation ACTTGATGGTTT _B	8723.933313	2.576483961	0.380312211	6.774654847	1.25E-11	4.66E-11
TCTTAGAGGGTG _A_Concatenation AGAGTGCGCTCT _B	9934.008985	-1.373247148	0.150755253	-9.109116426	8.31E-20	5.85E-19
							TCTTAGAGGGTG _A_Concatenation ATAACTCCACGC _B	1698.377181	3.254335631	0.608362516	5.349336204	8.83E-08	2.35E-07
TCTTAGAGGGTG _A_Concatenation ATGACCCCTTGT _B	1297.614228	1.932667118	0.516297332	3.743321916	0.000181603	0.000339671
							TCTTAGAGGGTG _A_Concatenation CTACGTGGCCCC _B	2864.773702	1.887592686	0.356690179	5.291967087	1.21E-07	3.14E-07
TCTTAGAGGGTG _A_Concatenation GAGATTGTGTCC _B	2702.107475	1.069024949	0.339439251	3.149385185	0.001636144	0.002701486
							TCTTGGTTTTGA _A_Concatenation ACTTGATGGTTT _B	5137.004474	2.817593061	0.190327188	14.80394413	1.38E-49	5.77E-48
TCTTGGTTTTGA _A_Concatenation AGAGTGCGCTCT _B	13199.65293	-1.589187701	0.177938744	-8.931094288	4.22E-19	2.80E-18
							TCTTGGTTTTGA _A_Concatenation ATAACTCCACGC _B	1673.558599	-1.585776296	0.256590073	-6.180193471	6.40E-10	2.10E-09
TCTTGGTTTTGA _A_Concatenation ATGACCCCTTGT _B	1110.849951	2.601857597	0.86405465	3.011218788	0.002602013	0.004149731
							TCTTGGTTTTGA _A_Concatenation CTACGTGGCCCC _B	4347.668806	-0.058402182	0.337794666	-0.172892554	0.862735885	0.883907318
TCTTGGTTTTGA _A_Concatenation GAGATTGTGTCC _B	3259.311251	1.003068615	0.37059663	2.706631776	0.00679696	0.010454798
							TGATGAGCGCCC _A_Concatenation ACTTGATGGTTT _B	25515.2802	1.948544725	0.201628521	9.664033227	4.29E-22	3.74E-21
TGATGAGCGCCC _A_Concatenation AGAGTGCGCTCT _B	40174.9284	-1.78389791	0.14226947	-12.53886664	4.57E-36	9.33E-35
							TGATGAGCGCCC _A_Concatenation ATAACTCCACGC _B	8264.16873	-0.729858195	0.389623817	-1.873238142	0.061035508	0.082012079
TGATGAGCGCCC _A_Concatenation ATGACCCCTTGT _B	2404.200024	-0.384694895	0.29607366	-1.299321581	0.193833591	0.237020364
							TGATGAGCGCCC _A_Concatenation CTACGTGGCCCC _B	8870.018591	1.727602207	0.218279543	7.914631766	2.48E-15	1.21E-14
TGATGAGCGCCC _A_Concatenation GAGATTGTGTCC _B	12717.27295	1.750387064	0.185141296	9.454330849	3.25E-21	2.62E-20
							TGCCAGACGGTC _A_Concatenation ACTTGATGGTTT _B	4510.886746	1.052444206	0.397232804	2.649439312	0.008062545	0.012288286
TGCCAGACGGTC _A_Concatenation AGAGTGCGCTCT _B	12203.32168	1.49634125	0.243676951	6.140676193	8.22E-10	2.67E-09
							TGCCAGACGGTC _A_Concatenation ATAACTCCACGC _B	2226.029711	-0.289680951	0.304542795	-0.951199492	0.341503116	0.396442048
TGCCAGACGGTC _A_Concatenation ATGACCCCTTGT _B	783.9451893	-1.282710293	0.387401864	-3.311058648	0.000929437	0.001604892
							TGCCAGACGGTC _A_Concatenation CTACGTGGCCCC _B	511.6013738	0.014106396	0.710152224	0.019863905	0.984151939	0.988379396
TGCCAGACGGTC _A_Concatenation GAGATTGTGTCC _B	7259.82545	-0.114018914	0.541302892	-0.210637917	0.833169822	0.859643003
							TGGCCCCCAGTT _A_Concatenation ACTTGATGGTTT _B	1753.655345	-0.193364443	0.340707643	-0.567537734	0.570348898	0.615639761
TGGCCCCCAGTT _A_Concatenation AGAGTGCGCTCT _B	709.7995748	-0.456607033	0.487135992	-0.937329698	0.348588991	0.403546833
							TGGCCCCCAGTT _A_Concatenation ATAACTCCACGC _B	1720.70992	-1.822296704	0.288489682	-6.316678953	2.67E-10	9.00E-10
TGGCCCCCAGTT _A_Concatenation ATGACCCCTTGT _B	875.4770592	-2.387857953	0.540489318	-4.417955864	9.96E-06	2.11E-05
							TGGCCCCCAGTT _A_Concatenation CTACGTGGCCCC _B	4944.371412	-1.374462897	0.2652007	-5.182727265	2.19E-07	5.57E-07
TGGCCCCCAGTT _A_Concatenation GAGATTGTGTCC _B	2738.201366	-0.806594213	0.306036809	-2.635611765	0.008398576	0.012750566
							TTAAATGAGGGC _A_Concatenation ACTTGATGGTTT _B	0
TTAAATGAGGGC _A_Concatenation AGAGTGCGCTCT _B	0
							TTAAATGAGGGC _A_Concatenation ATAACTCCACGC _B	0
TTAAATGAGGGC _A_Concatenation ATGACCCCTTGT _B	0
							TTAAATGAGGGC _A_Concatenation CTACGTGGCCCC _B	0
TTAAATGAGGGC _A_Concatenation GAGATTGTGTCC _B	0
							TTAGTGCCATAC _A_Concatenation ACTTGATGGTTT _B	4089.882088	3.932440362	0.99665856	3.945624431	7.96E-05	0.00015253
TTAGTGCCATAC _A_Concatenation AGAGTGCGCTCT _B	7283.312021	-0.823307279	0.229314819	-3.590292525	0.000330307	0.000604271
							TTAGTGCCATAC _A_Concatenation ATAACTCCACGC _B	1720.584853	-0.589194406	0.525843587	-1.120474644	0.262511552	0.314422135
TTAGTGCCATAC _A_Concatenation ATGACCCCTTGT _B	929.7064877	2.355566835	1.100306086	2.140828687	0.032287856	0.044987489
							TTAGTGCCATAC _A_Concatenation CTACGTGGCCCC _B	1217.381374	0.555779736	0.394127845	1.410150901	0.15849513	0.197107242
TTAGTGCCATAC _A_Concatenation GAGATTGTGTCC _B	1245.260138	2.319633216	0.765456969	3.030390094	0.002442381	0.003907883
							TTCTAATTTCCT _A_Concatenation ACTTGATGGTTT _B	12951.39885	-0.76441369	0.193074368	-3.95916713	7.52E-05	0.000144847
TTCTAATTTCCT _A_Concatenation AGAGTGCGCTCT _B	5536.76865	-0.847994458	0.149773074	-5.661861882	1.50E-08	4.24E-08
							TTCTAATTTCCT _A_Concatenation ATAACTCCACGC _B	1112.148194	2.379131032	1.200826686	1.981244305	0.047563883	0.065119489
TTCTAATTTCCT _A_Concatenation ATGACCCCTTGT _B	1868.207944	-2.315285466	0.382277849	-6.056551462	1.39E-09	4.36E-09
							TTCTAATTTCCT _A_Concatenation CTACGTGGCCCC _B	2491.36953	1.716095998	0.409061779	4.195200057	2.73E-05	5.46E-05
TTCTAATTTCCT _A_Concatenation GAGATTGTGTCC _B	5174.311018	0.665455092	0.197959458	3.361572619	0.000775	0.00136442
							TTTAACGGATTG _A_Concatenation ACTTGATGGTTT _B	7102.883505	-1.925070194	0.152000796	-12.66486919	9.26E-37	1.97E-35
TTTAACGGATTG _A_Concatenation AGAGTGCGCTCT _B	9789.187406	-1.970966116	0.179422164	-10.98507607	4.51E-28	5.99E-27
							TTTAACGGATTG _A_Concatenation ATAACTCCACGC _B	1635.59373	-2.09172008	0.415691771	-5.031901582	4.86E-07	1.19E-06
TTTAACGGATTG _A_Concatenation ATGACCCCTTGT _B	936.910252	-2.594250445	0.556343749	-4.663035124	3.12E-06	7.05E-06
							TTTAACGGATTG _A_Concatenation CTACGTGGCCCC _B	3248.860038	-2.595650747	0.332769212	-7.800152945	6.18E-15	2.96E-14
TTTAACGGATTG _A_Concatenation GAGATTGTGTCC _B	1459.234146	0.109469422	0.525289403	0.208398307	0.834917978	0.860687052
							Joint_1_A/u splice_ ACTTGATGGTTT _b	12602.18685	2.834282519	0.307436038	9.219096566	3.00E-20	2.19E-19
Joint_1_A/u splice_ AGAGTGCGCTCT _b	13857.04827	-1.407795098	0.151174797	-9.312366374	1.25E-20	9.51E-20
							Joint_1_A/u splice_ ATAACTCCACGC _b	1414.540746	0.869479763	0.942569942	0.922456492	0.356290514	0.411564833
Joint_1_A/u splice_ ATGACCCCTTGT _b	1444.921777	1.821238188	0.961015395	1.895118639	0.058076686	0.078487452
							Joint_1_A/u splice_ CTACGTGGCCCC _b	3161.063681	3.741360185	0.451001485	8.295671541	1.08E-16	5.87E-16
Joint_1_A/u splice_ GAGATTGTGTCC _b	4439.277102	2.339930864	0.288768714	8.103131495	5.36E-16	2.75E-15
							Joint_ 2_A/u splice_ ACTTGATGGTTT _b	4764.362017	1.302185917	0.318553825	4.087804998	4.35E-05	8.60E-05
Joint_ 2_A/u splice_ AGAGTGCGCTCT _b	4641.014609	-0.858114368	0.268247719	-3.198962409	0.001379232	0.002319887
							Joint_ 2_A/u splice_ ATAACTCCACGC _b	2312.608333	1.007811593	0.311329084	3.237126382	0.001207399	0.002063523
Joint_ 2_A/u splice_ ATGACCCCTTGT _b	869.5095131	-0.285909193	0.326995498	-0.874352078	0.381926547	0.436007942
							Joint_ 2_A/u splice_ CTACGTGGCCCC _b	1693.242298	1.340402916	0.586921782	2.283784584	0.022384194	0.032146343
Joint_ 2_A/u splice_ GAGATTGTGTCC _b	2229.334468	3.897228193	1.017061007	3.831852923	0.000127182	0.000240965
							Joint_ 3_A/u splice_ ACTTGATGGTTT _b	20972.98866	-0.931065923	0.174674411	-5.330293769	9.81E-08	2.59E-07
Joint_ 3_A/u splice_ AGAGTGCGCTCT _b	14106.2696	-1.077543821	0.230768459	-4.669372177	3.02E-06	6.84E-06
							Joint_ 3_A/u splice_ ATAACTCCACGC _b	12209.13927	1.775272594	0.129554249	13.70292841	9.75E-43	2.85E-41
Joint_ 3_A/u splice_ ATGACCCCTTGT _b	2505.160791	1.677157426	0.259069398	6.473776666	9.56E-11	3.34E-10
							Joint_ 3_A/u splice_ CTACGTGGCCCC _b	13055.01539	0.949972726	0.305937506	3.105120186	0.001902017	0.003096738
Joint_ 3_A/u splice_ GAGATTGTGTCC _b	13071.28484	1.250540812	0.13589717	9.202110778	3.51E-20	2.53E-19

TABLE 10 endogenous Gene validation screening

Bar code

Class A

Class B

Day 2_log2FC

Day 2_ padj

Day 8_log2FC

Day 8_ padj

Day 14_log2FC

Day 14_ padj

Day 14 \u alt_log2FC

Day 14_alt_ padj

Category a extension

Category B extension

A_ID

B_ID

A peptide

B peptide

State of combination

ATTTGTAGACCG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-3.463642398

0.02903062

-3.003231346

0.30068271

-22.21918925

0.724533156

15.39702108

0.001689303

Human target

neg_ctrl

MYCN

Random_1

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

Stop-1_A/u splice_ GAGATTGTGTCC _b

neg_ctrl

Target(s)

-1.627436671

0.16187644

-3.692147517

0.03832777

11.16585017

0.007680143

11.57361012

0.000990799

neg_ctrl

Virus_target

Stop_1

hvTR_Q2HR71

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Termination_X_strong

ACTTGATGGTTT _A_Concatenation CATTGTTTAAAT _B

Target(s)

Target(s)

0.358368292

0.73268364

6.81368932

0.00415692

15.31139868

0.000615278

11.44124604

0.014888877

Virus_target

Human target

hvTR_Q2HR73

POLR1E

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

Mid_X_unknown

AAAACAAGCATT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.291212195

0.13710355

5.050991528

11.49531014

0.013697255

11.22173713

0.003533249

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268803.1_88

hvTR_Q2HR71

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation AATCGATCCTAC _B

Target(s)

Target(s)

1.187220049

1.13E-05

5.424965834

0.01393042

2.099804209

0.959421461

11.06854166

5.73E-13

Virus_target

Human target

hvTR_Q2HR73

PRDM10

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

mid_X_mid

ATAACTCCACGC _A_Concatenation GGCACAGCTCCA _B

pos_ctrl_A

Target(s)

1.677766859

0.1798316

4.713241977

13.22676222

0.000615278

10.99197172

0.003038184

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

DTX2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

VIRF2_VP64_pos ctrl_x_unknown

CTACGTGGCCCC _A_Concatenation GGAGGCACATCG _B

Target(s)

Target(s)

0.587962509

0.3372476

-2.336900595

0.05332773

9.829872553

0.010044477

10.6963194

0.000470015

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q87042

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

Strong_X_strong

ACGACTCACCGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-2.494227768

0.49156691

-4.981795165

0.14175911

12.10068427

0.006685168

10.69187257

0.014756797

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

core_VP64_a

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CCCTGCCTCGGG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.175471785

0.76651497

5.280125963

0.00638945

3.537992144

0.641409749

10.39508229

6.06E-08

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

Random_1

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CTACGTGGCCCC _A_Concatenation TATCTATCGTGT _B

Target(s)

Target(s)

0.806061304

0.12515795

2.752006162

0.23699814

10.68350197

0.01463682

10.25424652

0.021401372

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03259

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation CCGCCCTTATGT _B

neg_ctrl

Target(s)

5.555496896

9.63E-75

12.37826167

1.30E-25

-0.408180374

0.998501722

10.19520655

0.000139482

neg_ctrl

Human target

Random_1

ZFX

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

Random_x_mid

GAGATTGTGTCC _A_Concatenation CCAGACGGTCTG _B

Target(s)

Target(s)

4.107593678

2.63E-50

13.29316804

-0.550800531

0.997690695

10.11839603

6.85E-05

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

Strong_x_weak

Stop 2_A splice ATGACCCCTTGT B

neg_ctrl

Target(s)

0.479260793

0.89056441

-0.02450146

0.98982201

10.64472131

0.037311924

10.09812267

0.040651866

neg_ctrl

Human target

Stop_2

LEUTX

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Termination_X_strong

ACTTGATGGTTT _A_Concatenation AATGGCACTAGC _B

Target(s)

Target(s)

4.136321997

7.26E-66

11.71054224

1.41E-26

0.013660142

0.998980766

10.09745322

3.41E-09

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_024711.1_cds_YP_009052522.2_44

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

Mid_X_weak

CTCACGACAAGA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.574870212

0.66469402

7.748547615

3.55E-13

1.411387083

0.997690695

9.902304554

3.12E-14

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_G3G929

core_VP64_a

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CTCCATTAATGA _B

neg_ctrl

Target(s)

0.119959975

0.926639

-5.887757856

0.00109019

10.52305524

0.014416269

9.802964914

0.024978026

neg_ctrl

Virus_target

Random_1

hvTR_Q5IXR3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

Random_x_weak

ATGACCCCTTGT _A_Concatenation AAGACCGGTGCC _B

Target(s)

Target(s)

3.222871153

2.76E-21

10.16328231

1.61E-15

-0.413316708

0.997690695

9.786927446

3.70E-08

Human target

Virus_target

LEUTX

hvTR_P08392

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

Strong_X_mid

CACACCCGGCAG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.313750639

0.04563877

1.527309891

0.33007775

9.13783676

0.013424967

9.785512442

0.001593463

Virus_target

Virus_target

hvTR_P19893

hvTR_Q2HR71

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TATCGCAAGAAC _A_Concatenation ATGACCCCTTGT _B

neg_ctrl

Target(s)

-1.481547652

0.02824838

3.405197617

0.00200126

8.928669924

0.013697255

9.671232973

0.001188078

neg_ctrl

Human target

Random_5

LEUTX

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Random_x_strong

ATGACAAAACGA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.818128085

0.03302877

4.956537401

0.04840645

1.261699218

0.997690695

9.524994268

3.65E-13

Virus_target

Human target

cds_NC_025350.1_cds_YP_009094074.1_1

LEUTX

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

TAAGATTCAACG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.175895712

0.80641597

6.167436043

0.00322932

-12.41618445

0.005760567

9.524773773

0.024114563

Human target

Human target

ZNF292

LEUTX

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

CAGTGACATAGT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.03920268

0.97418471

0.818673193

0.62046092

10.71864212

0.01049685

9.520527873

0.017149591

Human target

Virus_target

EHMT2

hvTR_Q2HR73

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GAGATTGTGTCC _A_Concatenation TAAGATTCAACG _B

Target(s)

Target(s)

1.268705673

0.01521957

8.164086967

2.60E-05

-2.997341245

0.848773578

9.388949471

0.006225935

Virus_target

Human target

hvTR_Q2HR71

ZNF292

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

Strong_X_strong

AGTTGCTTTGCT _A_Concatenation CTACGTGGCCCC _B

neg_ctrl

Target(s)

0.577303779

0.1639263

6.003819587

0.00224128

-2.741546785

0.871241789

9.333613067

0.002371643

neg_ctrl

Virus_target

Random_2

hvTR_Q2HR71

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Random_x_strong

ACTTGATGGTTT _A_Concatenation AGTTGCTTTGCT _B

Target(s)

neg_ctrl

-0.691496294

0.80286361

-4.818684306

0.07168116

10.46602713

0.005760567

9.274087677

0.006669939

Virus_target

neg_ctrl

hvTR_Q2HR73

Random_2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

Mid_X_random

AGAGTGCGCTCT _A_Concatenation TGCCAGACGGTC _B

neg_ctrl

Target(s)

1.029223434

0.16544842

-3.020111598

0.03888733

-12.3335532

0.00409751

9.166300733

0.042038866

neg_ctrl

Virus_target

Random_1

hvTR_P10541

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

Random_x_strong

GTACATACCGAA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-3.036940265

0.15677681

5.341118744

0.00095831

-4.401537116

9.123474948

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

hvTR_Q2HR71

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATGACCCCTTGT _A_Concatenation ATGTGGCACGAC _B

Target(s)

Target(s)

1.077030919

0.01879827

3.888636396

9.788818368

0.010044477

9.113663087

0.010118121

Human target

Human target

LEUTX

ANKRD17

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

Strong_X_mid

ACTTGATGGTTT _A_Concatenation TACTTCTAGCGG _B

Target(s)

Target(s)

0.671713663

0.09741707

5.379370488

0.00542747

-2.023130364

0.973675561

9.076876056

0.000470015

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_025350.1_cds_YP_009094080.1_7

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

Mid_X_weak

ATGACCCCTTGT _A_Concatenation GATGGAGCTACA _B

Target(s)

Target(s)

0.347533738

0.72753065

-6.135580134

0.00220481

-11.00294679

0.008547707

9.018961759

0.031425518

Human target

Virus_target

LEUTX

hvTR_P03209

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Strong_X_strong

GGCACTGTCGAG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.552037234

1.14E-40

5.305129936

1.14E-07

-0.106562398

0.998501722

9.00482691

3.07E-07

Virus_target

neg_ctrl

hvTR_P17147

Random_1

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

GTTCCACGCCTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.312879507

3.17E-27

5.143585346

3.35E-06

-0.067195717

0.998501722

8.911865562

4.03E-10

Human target

Virus_target

ZFX

hvTR_Q2HR73

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CTCGTTATGGCA _B

Target(s)

Target(s)

0.698570228

0.03930843

3.434874282

-11.64255281

0.002836034

8.813322585

0.020866488

Virus_target

Human target

hvTR_Q2HR71

NOVA1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

Strong_X_mid

ATGACCCCTTGT _A_Concatenation GTTCCACGCCTG _B

Target(s)

Target(s)

1.506779301

2.35E-30

5.90920395

2.85E-08

0.750660557

0.997690695

8.793027335

1.11E-09

Human target

Human target

LEUTX

ZFX

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

Strong_X_strong

TTCTAATTTCCT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.460415026

0.29541092

-3.670780763

0.01608804

-10.40897683

0.013424967

8.752477206

0.045483182

Human target

Virus_target

WDR76

hvTR_Q2HR71

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CATCTGAGTCGT _A_Concatenation CTACGTGGCCCC _B

pos_ctrl_A

Target(s)

0.704464119

0.00364994

3.354553919

0.02127152

4.728102918

0.313599588

8.748179961

5.64E-05

vIRF2_VP64_pos_ctrl

Virus_target

RWY_VP16_vIRF2

hvTR_Q2HR71

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VIRF2_VP64_pos strong_ctrl_x_strong

CTACGTGGCCCC _A_Concatenation ATCTCTCAGTTC _B

Target(s)

Target(s)

5.109216358

0.00479435

-1.561058745

0.59689983

0.361292

8.708850861

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

Strong_X_mid

Joint_1_A/u splice_ CTACGTGGCCCC _b

neg_ctrl

Target(s)

0.922993713

0.001233

-2.440330191

0.09193957

-10.15768613

0.015403937

8.652352489

0.049730741

neg_ctrl

Virus_target

Joint_1

hvTR_Q2HR71

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Joint_X_strong

CCCTATGTTCTA _A_Concatenation ATAACTCCACGC _B

pos_ctrl_A

pos_ctrl_A

-0.084286418

0.89056441

-4.59368123

0.00298056

10.27291873

0.005760567

8.641999877

0.013762881

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_b

core_VP64_a

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

Joint_ 3_A/u splice_ ATGACCCCTTGT _b

neg_ctrl

Target(s)

-0.266080949

0.38922543

5.779947485

0.01080066

10.01853312

0.007680143

8.637041421

0.013866638

neg_ctrl

Human target

Joint_3

LEUTX

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Joint_X_strong

ACTTGATGGTTT _A_Concatenation CGGCAATTGCTT _B

Target(s)

Target(s)

-1.457822561

0.00041066

-5.793769636

9.74E-06

8.360448954

0.018200984

8.594749615

0.005938192

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q9QB93

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

mid_X_mid

GAGATTGTGTCC _A_Concatenation TTAAATGAGGGC _B

Target(s)

Target(s)

-1.106091376

0.49700987

-3.5590441

0.23526565

-11.27049773

0.01068728

8.566673132

0.038129118

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

Strong_X_mid

GCGAGGCAGACC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.351249984

0.16544842

-5.384901622

0.02989572

-12.35765225

0.003914851

8.56354919

0.048359833

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

hvTR_Q2HR71

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

ATAACTCCACGC _A_Concatenation CCGCCCTTATGT _B

pos_ctrl_A

Target(s)

1.773949498

0.25106342

7.19197092

0.00554242

-3.781905878

8.547214128

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ZFX

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

vIRF2_VP64_pos_ctrl_X_mid

TGATGAGCGCCC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.344793988

2.55E-26

5.110659356

1.01E-07

0.40706954

0.997690695

8.518596789

1.60E-12

Human target

neg_ctrl

EEF1D

Random_1

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

GTTCCACGCCTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.468747959

0.86342423

6.344131903

1.08E-06

-1.725473963

8.514359599

Human target

Virus_target

ZFX

hvTR_Q2HR71

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation EPICXV.47_B

neg_ctrl

pos_ctrl_A

1.181055392

0.0391193

4.36387425

0.03785759

-10.50955972

0.010634211

8.47614677

0.032516708

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_1

3x_vIRF2_core

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

TAAAATTTATCA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.267233163

0.3372476

5.060331334

0.01115993

-10.2774351

0.008462651

8.439808168

0.024114563

Human target

Virus_target

HSF1

hvTR_Q2HR73

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATCTCTCAGTTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.471641559

0.86936399

1.431186174

-5.702284475

8.438455131

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

hvTR_Q2HR71

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTGGTAGTTGTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.36051598

3.21E-05

5.305392728

0.04394168

9.343547687

0.010044477

8.427055297

0.013365535

Virus_target

Virus_target

hvTR_F6KS47

hvTR_Q2HR71

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

ATAACTCCACGC _A_Concatenation CAACGCATGCCT _B

pos_ctrl_A

Target(s)

-0.159358465

0.90519313

-4.206018048

0.03359124

-10.64702017

0.010044477

8.380637875

0.052123751

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

VIRF2_VP64_pos ctrl_x_weak

GAGATTGTGTCC _A_Concatenation TCTGTACCAACG _B

Target(s)

Target(s)

0.88255408

0.00036657

4.942691993

0.00601804

-1.102235492

0.997690695

8.377224871

2.68E-08

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q6XA69

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

Strong_x_unknown

GAGATTGTGTCC _A_Concatenation CCCTGCCTCGGG _B

Target(s)

Target(s)

0.896690546

2.85E-08

4.962600718

0.00919494

9.365836563

0.010634211

8.368592116

0.016953736

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

Strong_X_mid

CTACGTGGCCCC _A_Concatenation AGTTAGGCTCTT _B

Target(s)

Target(s)

-0.20177753

0.26404203

5.64449311

0.00347065

9.758019231

0.009384904

8.351454723

0.019312927

Virus_target

Human target

hvTR_Q2HR71

TOX4

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

Strong_X_mid

GTACATACCGAA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.112767526

0.11078803

0.461232116

-9.640315773

0.017128651

8.32131175

0.044930268

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

hvTR_Q2HR73

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GTACATACCGAA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.304629792

0.48768396

5.118584334

0.00880421

-9.008287886

0.013424967

8.313758907

0.014269501

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

hvTR_Q2HR71

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATGACCCCTTGT _A_Concatenation ACAACGTGCATA _B

Target(s)

Target(s)

-0.026948112

0.9335834

2.919238068

2.303723965

0.878576426

8.292700867

1.11E-07

Human target

Virus_target

LEUTX

hvTR_P10407

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

Strong_X_strong

CCAGACGGTCTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.113468401

0.93141616

-6.233352431

7.87E-05

-9.049712443

0.031301413

8.223203079

0.047594012

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

hvTR_Q2HR73

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

AGAGTGCGCTCT _A_Concatenation AGCCAGGTCACC _B

neg_ctrl

Target(s)

1.843274291

0.20318702

-2.776815549

0.4314257

8.042169107

0.032334459

8.175432008

0.013342514

neg_ctrl

Human target

Random_1

MESP1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

Random_x_strong

GAGATTGTGTCC _A_Concatenation CATGCTAACACC _B

Target(s)

Target(s)

0.677641024

0.07423608

5.68162752

0.00224462

-3.176838108

0.668601651

8.152243641

8.11E-05

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_F5HCV3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

Strong_X_strong

ACTTGATGGTTT _A_Concatenation CACACCCGGCAG _B

Target(s)

Target(s)

0.56890209

0.47019918

-3.661843296

0.09821235

-10.03343679

0.010044477

8.135475876

0.020523923

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P19893

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

Mid_X_strong

TGCCAGACGGTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.849831622

1.11E-57

7.465320142

5.46E-10

-0.018339391

0.998980766

8.128216634

3.12E-14

Virus_target

Virus_target

hvTR_P10541

hvTR_Q2HR73

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

TGCCAGACGGTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.718555487

4.04E-57

7.040675547

3.03E-11

0.341850866

0.998501722

8.106708867

1.11E-266

Virus_target

Virus_target

hvTR_P10541

hvTR_Q2HR71

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

CTACGTGGCCCC _A_Concatenation TCTGTACCAACG _B

Target(s)

Target(s)

0.338397866

0.03952651

5.591561227

9.22E-06

3.798276949

0.51410768

8.105257146

4.75E-05

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q6XA69

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

Strong_x_unknown

ATAACTCCACGC _A_Concatenation TATTAAAAGTGC _B

pos_ctrl_A

Target(s)

-0.428182491

0.91132524

-3.256249648

0.27742577

-8.211751493

0.121748841

8.047026287

0.072895441

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_202

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

VIRF2_VP64_pos ctrl_x_weak

GGGAGTATGTCG _A_Concatenation CTACGTGGCCCC _B

neg_ctrl

Target(s)

0.994372916

0.49872084

2.199227781

8.849871636

0.031031764

8.033227141

0.043327277

neg_ctrl

Virus_target

Random_4

hvTR_Q2HR71

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Random_x_strong

GAGATTGTGTCC _A_Concatenation GCAACGAGGGTC _B

Target(s)

Target(s)

0.69588737

0.01226337

6.035742044

0.00332847

-8.891116836

0.013697255

8.015841384

0.019312927

Virus_target

Human target

hvTR_Q2HR71

QRICH2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

Strong_X_mid

GGCACTGTCGAG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.844173271

0.003519

5.658536069

0.03543209

-9.099015922

0.013789042

7.995264513

0.02616872

Virus_target

Virus_target

hvTR_P17147

hvTR_Q2HR71

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

AATCAACGAGCA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.134355205

0.71346073

6.032674181

6.36E-07

-2.565410005

0.827084874

7.970322286

1.10E-10

Human target

neg_ctrl

C2orf81

Random_1

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ACTTGATGGTTT _A_Concatenation TATCGCAAGAAC _B

Target(s)

neg_ctrl

-0.534561011

0.55849977

-6.250942664

0.00088003

-8.925504392

0.031438151

7.908569995

0.053375963

Virus_target

neg_ctrl

hvTR_Q2HR73

Random_5

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

Mid_X_random

GCAACGAGGGTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.93245887

0.10382793

-2.038043552

0.1185804

-8.558909782

0.040368381

7.888186097

0.057249341

Human target

Virus_target

QRICH2

hvTR_Q2HR71

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATAACTCCACGC _A_Concatenation ATGACAAAACGA _B

pos_ctrl_A

Target(s)

0.549699281

1.85E-05

5.694436396

0.00214973

-2.166437094

0.907768852

7.863100258

2.60E-07

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_025350.1_cds_YP_009094074.1_1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

VIRF2_VP64_pos strong_ctrl_x_strong

GAGATTGTGTCC _A_Concatenation GACTGTGGGCGG _B

Target(s)

Target(s)

0.699833746

0.92304294

3.248265669

0.2160146

3.182389004

7.820929841

Virus_target

Human target

hvTR_Q2HR71

MON2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CGGCAATTGCTT _B

Target(s)

Target(s)

-0.87344521

0.75207104

1.500155013

0.58424935

3.182389004

7.820929841

Human target

Virus_target

LEUTX

hvTR_Q9QB93

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

Strong_X_mid

CTACGTGGCCCC _A_Concatenation AGGCTTCCCGCT _B

Target(s)

Target(s)

-0.882861289

0.80641597

-3.354317901

0.33987316

3.182389004

7.820929841

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation GACTGTGGGCGG _B

neg_ctrl

Target(s)

-4.159852954

4.477125894

0.01342699

3.182389004

7.820929841

neg_ctrl

Human target

Random_1

MON2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

Random_x_strong

ATAACTCCACGC _A_Concatenation ATCTCTCAGTTC _B

pos_ctrl_A

Target(s)

1.021475407

0.05020483

-5.899487239

0.00055535

12.24207843

0.003293826

7.814648111

0.078603617

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CTACGTGGCCCC _B

pos_ctrl_A

Target(s)

-0.970571596

0.00852049

-3.894333782

0.00108214

-8.998423902

0.010634211

7.765168345

0.021401372

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q2HR71

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VIRF2_VP64_pos strong_ctrl_x_strong

AGAGTGCGCTCT _A_Concatenation GAGTGACCTATT _B

neg_ctrl

Target(s)

0.926559308

0.01063759

5.835977781

0.0030859

-2.480029226

0.846433413

7.712272998

1.03E-05

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

Random_x_unknown

CTACGTGGCCCC _A_Concatenation TCTTGGTTTTGA _B

Target(s)

Target(s)

0.78842733

0.10348588

1.696022505

0.44251631

-8.542847615

0.03963291

7.705659039

0.062240466

Virus_target

Human target

hvTR_Q2HR71

ZNF597

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation TGATGAGCGCCC _B

Target(s)

Target(s)

0.588388731

0.434377

3.986380963

0.0883946

-4.225558781

0.386178764

7.701181979

0.000249782

Human target

Human target

LEUTX

EEF1D

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

Strong_x_weak

ATAACTCCACGC _A_Concatenation ACCAGTATTTAA _B

pos_ctrl_A

Target(s)

0.683576529

0.10163584

5.169983535

0.00843344

-8.251747267

0.023733264

7.697459543

0.022916896

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ARNTL2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

VIRF2_VP64_pos strong_ctrl_x_strong

TCTATCACAACT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.682639397

3.85E-16

6.89865852

1.35E-11

-4.754507413

0.282213439

7.685191765

0.000604952

Human target

Virus_target

TOX4

hvTR_Q2HR71

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATGACCCCTTGT _A_Concatenation EPICXV.47_B

Target(s)

pos_ctrl_A

0.541557247

0.75878608

-6.805037577

0.00458448

-8.538761837

0.037311924

7.665495834

0.057593693

Human target

vIRF2_VP64_pos_ctrl

LEUTX

3x_vIRF2_core

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TTCTAATTTCCT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.794177652

0.36774226

4.665974015

0.07669979

-2.474694974

7.656169272

Human target

neg_ctrl

WDR76

Random_1

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

GAGATTGTGTCC _A_Concatenation CCGCCCTTATGT _B

Target(s)

Target(s)

-4.703491632

0.12519805

-4.609441729

0.13475115

-2.474694974

7.656169272

Virus_target

Human target

hvTR_Q2HR71

ZFX

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

Strong_X_mid

Joint_1_A/u splice_ ATGACCCCTTGT _b

neg_ctrl

Target(s)

0.394136657

0.88343822

-0.090714014

-2.474694974

7.656169272

neg_ctrl

Human target

Joint_1

LEUTX

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Joint_X_strong

ATAACTCCACGC _A_Concatenation ATCCAATCTGTG _B

pos_ctrl_A

Target(s)

0.650896034

0.91465995

-7.081509867

7.653290084

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

GLI2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

vIRF2_VP64_pos_ctrl_X_mid

TCTGTACCAACG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.791455752

0.00785913

-1.88030649

0.26956633

8.646985846

0.014416269

7.640775335

0.024390507

Virus_target

neg_ctrl

hvTR_Q6XA69

Random_1

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

ATAACTCCACGC _A_Concatenation ATGTGGCACGAC _B

pos_ctrl_A

Target(s)

0.641890332

1.47E-06

4.899229592

0.00810947

-2.262580913

0.877171774

7.639289022

1.10E-06

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ANKRD17

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

vIRF2_VP64_pos_ctrl_X_mid

ACTTGATGGTTT _A_Concatenation CCAGACGGTCTG _B

Target(s)

Target(s)

0.196096406

0.7214152

3.190731301

0.05166799

7.184898497

0.037311924

7.58221318

0.008616869

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

Mid_X_weak

TGATGAGCGCCC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.170016441

0.85449119

4.574274272

8.99E-05

8.660383291

0.013697255

7.534873296

0.024390507

Human target

Human target

EEF1D

LEUTX

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.71367231

5.18E-09

6.185353501

6.51E-14

-0.571016588

0.997690695

7.460628152

5.89E-12

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q2HR71

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

GGCCTTTCGGGC _A_Concatenation GAGATTGTGTCC _B

neg_ctrl

Target(s)

-0.370682457

0.55882961

4.244894033

-9.412315455

0.010044477

7.451282675

0.038629478

neg_ctrl

Virus_target

Random_3

hvTR_Q2HR71

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Random_x_strong

ATGTGGCACGAC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.09503707

0.85386731

-5.658715328

0.00038416

-8.732218594

0.034652658

7.411667637

0.073394906

Human target

Virus_target

ANKRD17

hvTR_Q2HR73

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ACTCGTGTTGTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.933547888

0.04563877

5.663934779

0.01080066

-8.370596018

0.039318978

7.407951899

0.065462272

Virus_target

neg_ctrl

hvTR_Q9QB97

Random_1

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TCTTAGAGGGTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.447646944

0.33804652

6.230481486

0.00013177

-4.688684329

0.287920482

7.401409185

0.001244361

Human target

Human target

TRO

LEUTX

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation CATTAGTCCCGC _B

neg_ctrl

Target(s)

0.339728174

0.91324404

6.332730281

0.01752569

-10.55211288

0.008547707

7.391569974

0.047229778

neg_ctrl

Virus_target

Random_1

hvTR_P06930

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

Random_x_strong

GCAACGAGGGTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.127345911

1.21E-07

2.953757152

0.0883946

-8.540949516

0.01463682

7.382284708

0.030899299

Human target

vIRF2_VP64_pos_ctrl

QRICH2

core_VP64_a

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACAACGTGCATA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.367173601

0.0878806

4.339796723

0.01981257

0.713647901

0.997690695

7.365499688

4.82E-11

Virus_target

Virus_target

hvTR_P10407

hvTR_Q2HR71

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CAGTGACATAGT _B

Target(s)

Target(s)

-0.638970843

0.19699665

2.666397192

0.20783496

-8.021739216

0.057076235

7.263387238

0.073394906

Human target

Human target

LEUTX

EHMT2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

Strong_X_mid

ATTGTATCTAAC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.24455974

0.5252844

0.933374222

0.58407409

8.096956646

0.01463682

7.132367256

0.023033881

Human target

Human target

SMARCB1

LEUTX

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGATTGTGTCC _A_Concatenation EPICXV.47_B

Target(s)

pos_ctrl_A

0.84943315

0.01041536

5.292348308

0.01153845

-2.958427043

0.679495956

7.131041645

9.86E-05

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

3x_vIRF2_core

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AAACTTTGAGCG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.186648247

0.55752411

-4.495524771

0.00054941

-8.180239368

0.021245195

7.12411116

0.036860748

Human target

Human target

ATF6B

LEUTX

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AATGGCACTAGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.393476475

0.51381092

3.555384926

0.03980823

8.600579785

0.012328448

7.110854791

0.029747778

Virus_target

Virus_target

cds_NC_024711.1_cds_YP_009052522.2_44

hvTR_Q2HR71

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

TGCCAGACGGTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.128067764

0.86727966

4.975760846

3.73E-06

-4.555968363

0.293964969

7.094708216

0.00206584

Virus_target

Human target

hvTR_P10541

LEUTX

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ATTGTATCTAAC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.577875132

0.00077305

5.853344778

8.42E-11

-8.23048064

0.024322502

7.047382471

0.045483182

Human target

Virus_target

SMARCB1

hvTR_Q2HR73

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATGACCCCTTGT _A_Concatenation CTCACGACAAGA _B

Target(s)

Target(s)

0.309333447

0.22734303

4.239753439

0.02675203

-9.235195175

0.017210958

6.988338799

0.084897118

Human target

Virus_target

LEUTX

hvTR_G3G929

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CACACCCGGCAG _B

Target(s)

Target(s)

3.018107924

0.00015112

-4.623899275

0.08162571

10.25436772

0.010044477

6.986014056

0.07764548

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P19893

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

Strong_X_strong

ATAACTCCACGC _A_Concatenation CATTAGTCCCGC _B

pos_ctrl_A

Target(s)

-1.645745018

0.1490407

4.21019857

0.15762866

7.950859248

0.024855315

6.931958177

0.03998295

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P06930

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

VIRF2_VP64_pos strong_ctrl_x_strong

AGCCGTGCTTGA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.878123356

7.29E-24

4.526014459

3.45E-09

-2.22960665

0.872533238

6.893945788

1.25E-05

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

hvTR_Q2HR71

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

GAGATTGTGTCC _A_Concatenation CCCTATGTTCTA _B

Target(s)

pos_ctrl_A

-0.178079772

0.4482293

-5.111208709

0.00542747

-7.535138383

0.037311924

6.809056893

0.04282005

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

core_VP64_b

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation TGATGAGCGCCC _B

Target(s)

Target(s)

0.157480431

0.61264864

5.765720157

0.00428769

-8.19539128

0.03963291

6.768714549

0.091603543

Virus_target

Human target

hvTR_Q2HR71

EEF1D

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

Strong_x_weak

GAGATTGTGTCC _A_Concatenation GAGTGACCTATT _B

Target(s)

Target(s)

1.730596028

2.15E-47

5.93173213

3.97E-07

7.168872131

0.044830089

6.739547537

0.040651866

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

Strong_x_unknown

CTACGTGGCCCC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.337180443

0.07843366

2.573158999

0.09959926

-5.414924903

0.14287914

6.706022541

0.00670365

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR71

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation TCTTGGTTTTGA _B

neg_ctrl

Target(s)

-0.74503331

0.14064671

8.313550125

0.0011281

4.328708948

0.362786872

6.646346356

0.011977532

neg_ctrl

Human target

Random_1

ZNF597

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

Random_x_strong

AGAGTGCGCTCT _A_Concatenation ATGACAAAACGA _B

neg_ctrl

Target(s)

1.410529323

9.91E-05

-4.150328263

0.00350005

7.062387535

0.038202744

6.64251345

0.030287396

neg_ctrl

Virus_target

Random_1

cds_NC_025350.1_cds_YP_009094074.1_1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

Random_x_strong

ACTTGATGGTTT _A_Concatenation CGCCGGCATACA _B

Target(s)

Target(s)

-0.197936285

0.68632574

-7.095341077

8.78E-05

-7.576259922

0.037311924

6.626304899

0.053105771

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_030656.1_cds_YP_009268729.1_14

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

Mid_X_strong

ACTTGATGGTTT _A_Concatenation GGAGGCACATCG _B

Target(s)

Target(s)

-0.316675898

0.03929624

3.350519782

0.00159403

-4.420398391

0.293964969

6.602698477

0.003106839

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q87042

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

Mid_X_strong

TGCCAGACGGTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.717532585

4.59E-12

5.872358314

8.76E-11

2.464141404

0.812553322

6.584128232

6.86E-05

Virus_target

Virus_target

hvTR_P10541

hvTR_Q2HR71

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CCCTGCCTCGGG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.748257237

2.99E-20

6.318333506

2.79E-08

6.460286125

0.057907582

6.579359253

0.021459435

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

hvTR_Q2HR71

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATGACCCCTTGT _A_Concatenation TAAAATTTATCA _B

Target(s)

Target(s)

1.606770111

4.86E-27

6.057202717

4.82E-07

2.124398883

0.878578286

6.505290123

3.04E-05

Human target

Human target

LEUTX

HSF1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

Strong_X_mid

ATGACCCCTTGT _A_Concatenation GGCACAGCTCCA _B

Target(s)

Target(s)

0.984042253

0.02618256

6.179487016

0.0022556

-8.45326965

0.032851053

6.497017144

0.103147793

Human target

Human target

LEUTX

DTX2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

Strong_x_unknown

ATGACCCCTTGT _A_Concatenation TCAGCCGTAGGC _B

Target(s)

Target(s)

-0.219410497

0.38922543

6.020366948

4.09E-05

3.857306341

0.412917083

6.393026493

0.002470579

Human target

Virus_target

LEUTX

hvTR_Q805Y1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

Strong_X_mid

GGCCTTTCGGGC _A_Concatenation ACTTGATGGTTT _B

neg_ctrl

Target(s)

0.037292078

0.95906455

0.673923387

0.78843818

-6.958853731

0.122481178

6.35425437

0.112333694

neg_ctrl

Virus_target

Random_3

hvTR_Q2HR73

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Random_x_mid

ATGACCCCTTGT _A_Concatenation CATTGTTTAAAT _B

Target(s)

Target(s)

-0.654300763

0.86442316

2.70043121

3.19850768

6.340800955

Human target

Human target

LEUTX

POLR1E

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

Strong_x_unknown

ACTTGATGGTTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-3.506945951

0.5449371

4.276073406

0.10260338

3.19850768

6.340800955

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q2HR71

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CTACGTGGCCCC _A_Concatenation CATTGTTTAAAT _B

Target(s)

Target(s)

0.275748237

0.81782989

-5.130312394

0.00212861

3.19850768

6.340800955

Virus_target

Human target

hvTR_Q2HR71

POLR1E

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

Strong_x_unknown

ATGACCCCTTGT _A_Concatenation TGGCCCCCAGTT _B

Target(s)

Target(s)

1.35649995

0.5449371

3.909200449

2.734260423

6.319993521

Human target

Virus_target

LEUTX

hvTR_Q3I8P6

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

Strong_x_weak

CTGCCGGTTGCG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.717439327

0.00016173

4.785605962

0.00061704

6.902284204

0.032851053

6.296303404

0.029747778

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

hvTR_Q2HR71

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATGACCCCTTGT _A_Concatenation ACTTTAGTAACA _B

Target(s)

Target(s)

-0.341033992

0.00096247

3.391356102

0.0053351

-1.797926493

0.957192732

6.261209443

3.16E-05

Human target

Virus_target

LEUTX

hvTR_Q69113

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

Strong_X_strong

CAACGCATGCCT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.850450243

0.03846116

3.365446093

0.1690105

7.805674581

0.019323708

6.251352533

0.051926957

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

LEUTX

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

GAGTGACCTATT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.606450251

0.93141616

1.978973151

0.33412121

-2.112805223

6.230613334

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

hvTR_Q2HR73

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

CAGTGACATAGT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.889230969

0.0994125

4.709347227

0.02096729

8.240196255

0.032851053

6.212455053

0.110875085

Human target

neg_ctrl

EHMT2

Random_1

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CTACGTGGCCCC _A_Concatenation ATGACAAAACGA _B

Target(s)

Target(s)

-0.325532863

8.79E-05

2.987947112

0.01328684

-1.170979709

0.997690695

6.205129932

1.80E-06

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094074.1_1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation TGATGAGCGCCC _B

neg_ctrl

Target(s)

0.674483413

2.99E-05

4.838687807

0.01658458

-1.776214416

0.95807515

6.193449665

2.74E-05

neg_ctrl

Human target

Random_1

EEF1D

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

Random_x_weak

AGAGTGCGCTCT _A_Concatenation ATTTGTAGACCG _B

neg_ctrl

Target(s)

-0.418006152

5.99E-07

3.323023044

0.00572381

-1.480915271

0.987041604

6.188928586

6.07E-06

neg_ctrl

Human target

Random_1

MYCN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

Random_x_mid

CATTAGTCCCGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.372980136

0.79871251

2.284801106

0.23647027

-8.477170869

0.024008997

6.174686499

0.105019042

Virus_target

Virus_target

hvTR_P06930

hvTR_Q2HR71

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATAACTCCACGC _A_Concatenation TCTGTACCAACG _B

pos_ctrl_A

Target(s)

0.541422669

0.01223661

5.406175504

0.0045335

-4.445832933

0.282213439

6.161499231

0.007678852

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q6XA69

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

VIRF2_VP64_pos ctrl_x_unknown

CTACGTGGCCCC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.361809382

0.0008871

3.193455072

0.00893844

-1.427185386

0.995270541

6.159230965

1.06E-05

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

GATCGCATGTTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.200750408

0.76651497

5.031563292

0.02106667

7.535132388

0.063801421

6.119721715

0.119830883

Human target

Human target

INPP4A

LEUTX

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ACTTGATGGTTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.336722369

0.01420547

3.245423411

0.00752982

-1.46942369

0.987041604

6.111315085

1.51E-05

Virus_target

Human target

hvTR_Q2HR73

LEUTX

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GGGAGTATGTCG _A_Concatenation GAGATTGTGTCC _B

neg_ctrl

Target(s)

-4.044708888

0.26523132

3.522458847

0.17663032

-4.582413654

6.078038084

neg_ctrl

Virus_target

Random_4

hvTR_Q2HR71

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Random_x_strong

ATAACTCCACGC _A_Concatenation AAGCAACGATAT _B

pos_ctrl_A

Target(s)

0.126628979

0.85681444

-5.322501137

4.73E-05

-3.496584394

0.51410768

5.999225039

0.005938192

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

vIRF2_VP64_pos_ctrl_X_mid

CGCCGGCATACA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.658231269

5.51E-10

3.269640187

0.03888733

-7.049005246

0.034542461

5.967395052

0.053093786

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268729.1_14

hvTR_Q2HR71

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

TATCGCAAGAAC _A_Concatenation ACTTGATGGTTT _B

neg_ctrl

Target(s)

-0.766526056

8.29E-12

3.02075261

0.01096213

6.278935959

0.057490126

5.963147582

0.037017444

neg_ctrl

Virus_target

Random_5

hvTR_Q2HR73

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Random_x_mid

AGAGTGCGCTCT _A_Concatenation TAAGATTCAACG _B

neg_ctrl

Target(s)

0.772902269

0.60833425

-0.461147923

9.550580489

0.011217716

5.941055263

0.12609254

neg_ctrl

Human target

Random_1

ZNF292

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

Random_x_strong

CTACGTGGCCCC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.134604353

0.72546447

-2.279760169

0.10968094

-6.760429115

0.070775661

5.880306523

0.079863392

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR73

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATAACTCCACGC _A_Concatenation AGAGTGCGCTCT _B

pos_ctrl_A

neg_ctrl

0.538570889

0.73293852

-2.56907084

0.16091351

5.339876323

0.157574718

5.810337233

0.038754945

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Random_1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VIRF2_VP64_pos ctrl_x_random

TCTATCACAACT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.725875387

3.422691034

0.09936833

-5.867398127

0.192744457

5.782993122

0.066071339

Human target

Virus_target

TOX4

hvTR_Q2HR73

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CTGGTAGTTGTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.014430461

0.9854934

2.555604322

-2.945954063

0.666430638

5.751999664

0.010952256

Virus_target

Human target

hvTR_F6KS47

LEUTX

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

TCTATCACAACT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

2.450058918

0.66445658

4.930459559

0.00659263

0.549259713

5.705303242

Human target

neg_ctrl

TOX4

Random_1

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CTACGTGGCCCC _A_Concatenation TCTTAGAGGGTG _B

Target(s)

Target(s)

0.047194761

0.88448623

3.34870272

0.094757

6.161150021

0.083289714

5.700507043

0.057793972

Virus_target

Human target

hvTR_Q2HR71

TRO

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

Strong_X_strong

TAAAATTTATCA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.005357119

0.434377

5.264303211

-6.177765888

5.696845592

Human target

neg_ctrl

HSF1

Random_1

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ACCAGTATTTAA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.625794165

0.34506942

-2.302547309

0.2598498

-6.479473449

0.143457767

5.659119579

0.14600867

Human target

Human target

ARNTL2

LEUTX

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CTCAGCGATATA _B

Target(s)

Target(s)

-0.884299816

0.00030933

-2.44964826

0.15212449

4.214676328

0.294130007

5.650487209

0.013542366

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q5Y0Q4

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation CTCGCACCGAGG _B

neg_ctrl

Target(s)

-2.248100258

0.27973193

1.91838485

0.22163368

-3.992840406

5.642017357

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

Random_x_mid

TGATGAGCGCCC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.128203736

0.81690552

4.275579049

0.00201847

-4.232883325

0.293489659

5.641065858

0.013342514

Human target

Virus_target

EEF1D

hvTR_Q2HR71

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation CTCACGACAAGA _B

Target(s)

Target(s)

0.512788805

0.19856441

-6.761446257

9.73E-06

6.931387361

0.044830089

5.613397995

0.083931183

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_G3G929

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

Mid_X_strong

ATGACAAAACGA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.767556927

0.59461055

-1.460186931

0.49066643

-8.786311219

0.0333998

5.602273733

0.141823166

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094074.1_1

hvTR_Q2HR73

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTACGTGGCCCC _A_Concatenation AGCCATAAACCT _B

Target(s)

Target(s)

0.604078556

0.01809398

3.294447575

0.0030859

-6.459509617

0.157574718

5.573094039

0.166180187

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03209

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

Strong_X_mid

ACTTGATGGTTT _A_Concatenation CAGTGACATAGT _B

Target(s)

Target(s)

-0.868991746

0.00328682

2.434942105

0.24676367

-6.170530665

0.132193841

5.527243828

0.105824256

Virus_target

Human target

hvTR_Q2HR73

EHMT2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

mid_X_mid

AGAGTGCGCTCT _A_Concatenation GCAACGAGGGTC _B

neg_ctrl

Target(s)

-0.73672478

0.28451306

2.960379355

0.2079163

4.622730402

0.219924157

5.518910518

0.020523923

neg_ctrl

Human target

Random_1

QRICH2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

Random_x_mid

CATCTGAGTCGT _A_Concatenation GAGATTGTGTCC _B

pos_ctrl_A

Target(s)

0.68144834

3.41E-08

4.647580585

7.29E-05

-1.749733886

0.953105946

5.493306706

0.000198815

vIRF2_VP64_pos_ctrl

Virus_target

RWY_VP16_vIRF2

hvTR_Q2HR71

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VIRF2_VP64_pos strong_ctrl_x_strong

TATCGCAAGAAC _A_Concatenation CTACGTGGCCCC _B

neg_ctrl

Target(s)

-0.437809724

8.07E-05

3.990982145

0.00080811

2.941277101

0.624937505

5.478556335

0.003715881

neg_ctrl

Virus_target

Random_5

hvTR_Q2HR71

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Random_x_strong

ATGACCCCTTGT _A_Concatenation CATCTCACCTAG _B

Target(s)

Target(s)

-0.616296947

0.00211261

-1.818350993

0.25412646

4.014576765

0.331166233

5.471178659

0.015867719

Human target

Virus_target

LEUTX

hvTR_P03206

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

Strong_X_mid

GAGATTGTGTCC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.448570292

1.14E-36

2.198877341

0.06287927

-5.50748689

0.097296843

5.458903719

0.03571309

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR73

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation CATCTCACCTAG _B

neg_ctrl

Target(s)

0.57712913

0.27877822

3.749769461

0.06126631

-6.027259113

0.199492182

5.430632539

0.166180187

neg_ctrl

Virus_target

Random_1

hvTR_P03206

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

Random_x_mid

TATCGCAAGAAC _A_Concatenation GAGATTGTGTCC _B

neg_ctrl

Target(s)

-0.62509196

4.51E-13

5.523717251

3.18E-05

-1.348705749

0.996490702

5.38039431

6.86E-05

neg_ctrl

Virus_target

Random_5

hvTR_Q2HR71

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Random_x_strong

ATAACTCCACGC _A_Concatenation Joint_ 3_B

pos_ctrl_A

neg_ctrl

-1.301941061

0.61787605

-2.06316216

0.5129823

3.252755424

5.367283212

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Joint_3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

VIRF2_VP64_pos ctrl X joint

AGCCGTGCTTGA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.01277519

0.94601266

5.007069331

0.00039124

-0.437400967

0.997690695

5.324969817

1.08E-06

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

LEUTX

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

TCTGTACCAACG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

3.73784303

0.1062238

-1.714863241

2.692466488

5.307560891

Virus_target

Virus_target

hvTR_Q6XA69

hvTR_Q2HR73

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

GAGATTGTGTCC _A_Concatenation ATGACAAAACGA _B

Target(s)

Target(s)

0.414630977

0.04988573

-1.555194347

0.36688342

-6.922708071

0.038202744

5.307523378

0.096401552

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094074.1_1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

Strong_X_strong

CACACCCGGCAG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.721267944

3.00E-06

4.803838669

0.00021381

-2.259591951

0.827084874

5.302231035

0.002219785

Virus_target

Virus_target

hvTR_P19893

hvTR_Q2HR71

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CTACGTGGCCCC _A_Concatenation CCCCTTAGGAAT _B

Target(s)

Target(s)

-0.415735662

0.00342394

4.10137785

0.01608804

5.772574839

0.094980347

5.25076635

0.064978326

Virus_target

Human target

hvTR_Q2HR71

SYNE1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

Strong_X_mid

ACTTGATGGTTT _A_Concatenation CCGCCCTTATGT _B

Target(s)

Target(s)

-2.566978842

0.17011976

0.124097897

0.95625121

-1.872655101

5.246885141

Virus_target

Human target

hvTR_Q2HR73

ZFX

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

mid_X_mid

ACTTGATGGTTT _A_Concatenation CATTAGTCCCGC _B

Target(s)

Target(s)

0.872044681

4.58E-08

2.318146865

0.14351379

-1.723372103

0.953105946

5.119439014

0.000956228

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P06930

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

Mid_X_strong

ACTTGATGGTTT _A_Concatenation GCAACGAGGGTC _B

Target(s)

Target(s)

0.071133467

0.82429662

2.390838029

0.17619603

-5.15379121

0.132483935

5.098128037

0.049730741

Virus_target

Human target

hvTR_Q2HR73

QRICH2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

mid_X_mid

GCAACGAGGGTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

2.703348434

0.00517376

3.418632406

0.05506627

-5.72392502

5.068979119

Human target

Virus_target

QRICH2

hvTR_Q2HR71

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation ACTCGTGTTGTC _B

neg_ctrl

Target(s)

0.568844848

0.11961968

5.1190242

0.01166474

-4.488430838

0.224079904

5.051946961

0.037329215

neg_ctrl

Virus_target

Random_1

hvTR_Q9QB97

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

Random_x_mid

AGAGTGCGCTCT _A_Concatenation AAGGGTAAATTG _B

neg_ctrl

Target(s)

2.25023623

8.92E-13

7.857077919

3.60E-10

-2.821647733

0.634646987

5.035129856

0.007557258

neg_ctrl

Virus_target

Random_1

hvTR_Q69513

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

Random_x_mid

Stop-1_A/u splice_ ACTTGATGGTTT _b

neg_ctrl

Target(s)

-0.685381147

0.21779974

2.599760865

0.29336258

5.914021925

0.102621121

5.017089571

0.098722329

neg_ctrl

Virus_target

Stop_1

hvTR_Q2HR73

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Termination_X_mid

ACTTTAGTAACA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.978906718

0.29193745

-0.556849683

0.70600688

7.275519454

0.057907582

4.985211359

0.205419389

Virus_target

Human target

hvTR_Q69113

LEUTX

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ATAACTCCACGC _A_Concatenation CTCGTTATGGCA _B

pos_ctrl_A

Target(s)

-0.620434447

0.7723094

1.942028427

0.37601

-3.802465784

4.906448941

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

NOVA1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

vIRF2_VP64_pos_ctrl_X_mid

AGAGTGCGCTCT _A_Concatenation CTGCCGGTTGCG _B

neg_ctrl

Target(s)

-1.006323764

0.00702337

2.40315768

-5.31606666

0.238404099

4.904881664

0.156071982

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

Random_x_mid

ACTTGATGGTTT _A_Concatenation CTCGCACCGAGG _B

Target(s)

Target(s)

0.027329402

0.93141616

3.6256305

0.10029123

5.262055987

0.147334557

4.903163109

0.083931183

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

mid_X_mid

CTACGTGGCCCC _A_Concatenation CTGGTAGTTGTT _B

Target(s)

Target(s)

-0.642305999

5.44E-08

4.607495407

0.01080066

-2.171575653

0.834609851

4.881624466

0.00409792

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_F6KS47

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

Strong_x_unknown

AGCCGTGCTTGA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.713838

8.42E-15

4.721963507

0.00010641

3.01746559

0.572967985

4.871259689

0.013542366

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

Random_1

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

TTAGTGCCATAC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.458630922

0.9002656

-4.311999143

0.19857061

-4.368937873

4.861460917

Human target

neg_ctrl

TET3

Random_1

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ACTTGATGGTTT _A_Concatenation AAGGGTAAATTG _B

Target(s)

Target(s)

0.236760216

0.41025376

2.484753585

0.08844163

6.327382813

0.049730355

4.854162722

0.103147793

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q69513

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

mid_X_mid

ACTTGATGGTTT _A_Concatenation Joint_ 1_B

Target(s)

neg_ctrl

-0.448839266

1.61E-08

1.091281679

0.48142569

-0.769203873

0.997690695

4.846880808

4.80E-05

Virus_target

neg_ctrl

hvTR_Q2HR73

Joint_1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

Mid_X_joint

GCGAGGCAGACC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.495120472

0.33149001

-5.675425183

0.00016952

-4.048654583

0.293489659

4.840659795

0.032446636

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

core_VP64_a

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

TTTAACGGATTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.313455045

0.72633824

-5.046716429

0.00109019

6.867457986

0.032851053

4.829196686

0.114829927

Human target

Virus_target

TWIST2

hvTR_Q2HR71

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ACGGCGTAAGTA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.152739419

1.86107202

0.50348283

0.626306341

4.819065922

Virus_target

Human target

cds_NC_025350.1_cds_YP_009094078.1_5

LEUTX

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATCCAATCTGTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

3.225471538

0.1798316

-1.231031929

0.626306341

4.819065922

Human target

Human target

GLI2

LEUTX

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATGACCCCTTGT _A_Concatenation TACATGAGGCAC _B

Target(s)

Target(s)

-1.29829054

0.78044287

-3.78994125

0.18898801

0.626306341

4.819065922

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

Strong_X_mid

GAGTGACCTATT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.766177256

0.91394475

8.061353226

0.0004211

0.626306341

4.819065922

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

hvTR_Q2HR71

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

ATCTCTCAGTTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.401493697

0.93141616

3.915678524

0.01832212

0.626306341

4.819065922

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

LEUTX

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CTACGTGGCCCC _A_Concatenation AGTTGCTTTGCT _B

Target(s)

neg_ctrl

0.024087327

0.99110789

1.320373251

0.62046092

0.626306341

4.819065922

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

Strong_X_random

GAGTGACCTATT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-2.008848691

0.50396632

2.531243998

0.09245164

0.626306341

4.819065922

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

hvTR_Q2HR71

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

ACTCGTGTTGTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

5.888128791

0.11942756

4.177353315

0.03154261

0.626306341

4.819065922

Virus_target

Human target

hvTR_Q9QB97

LEUTX

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGGCTTCCCGCT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.063695227

2.383584984

0.626306341

4.819065922

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

LEUTX

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATGACCCCTTGT _A_Concatenation GACTGTGGGCGG _B

Target(s)

Target(s)

0.400705299

0.94601266

2.660356044

0.2646259

0.626306341

4.819065922

Human target

Human target

LEUTX

MON2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

Strong_X_strong

AAGGGTAAATTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.411486358

0.92304294

0.626306341

4.819065922

Virus_target

Virus_target

hvTR_Q69513

hvTR_Q2HR73

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CCGCCCTTATGT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-2.874592287

0.04755468

2.526318689

0.26334677

0.626306341

4.819065922

Human target

Virus_target

ZFX

hvTR_Q2HR73

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATAACTCCACGC _A_Concatenation ATAACTCCACGC _B

pos_ctrl_A

pos_ctrl_A

2.872711071

0.58303182

3.88115205

0.626306341

4.819065922

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_a

core_VP64_a

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

AAGGGTAAATTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.429753257

0.22734303

1.879481815

0.61804847

0.626306341

4.819065922

Virus_target

Virus_target

hvTR_Q69513

hvTR_Q2HR71

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CCAGACGGTCTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.677957275

0.52901596

-2.991824273

0.626306341

4.819065922

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

hvTR_Q2HR71

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

GTACATACCGAA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-5.753126713

0.02537355

3.348134157

0.12383329

0.626306341

4.819065922

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

Random_1

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGATTGTGTCC _A_Concatenation Stop_1_B

Target(s)

neg_ctrl

3.924025072

0.08319708

3.437785233

0.06755234

0.626306341

4.819065922

Virus_target

neg_ctrl

hvTR_Q2HR71

Stop_1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

Strong_X_termination

ATGACCCCTTGT _A_Concatenation TACTTCTAGCGG _B

Target(s)

Target(s)

0.573167945

0.93141616

4.314475304

0.04580015

0.626306341

4.819065922

Human target

Virus_target

LEUTX

cds_NC_025350.1_cds_YP_009094080.1_7

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

Strong_x_weak

ATGACCCCTTGT _A_Concatenation ATTGTATCTAAC _B

Target(s)

Target(s)

0.530604996

0.82433714

-2.554333293

0.37627633

0.626306341

4.819065922

Human target

Human target

LEUTX

SMARCB1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

Strong_X_mid

GAGACAGCTCTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.042591165

0.99110789

1.753604194

0.42967531

0.626306341

4.819065922

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

core_VP64_a

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

TATTAAAAGTGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

4.513738497

0.09354755

3.180465029

0.008531041

4.817650637

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_202

hvTR_Q2HR71

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

GCAGATTCGAAT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.968965852

0.74622616

2.714505633

0.008531041

4.817650637

Human target

Human target

AK9

LEUTX

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AATCGAGACCAG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.01068637

0.99738617

1.674848326

0.52560211

0.008531041

4.817650637

Virus_target

Virus_target

hvTR_Q8BB47

hvTR_Q2HR71

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CCGCCCTTATGT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.048836165

3.597606602

0.23767729

0.008531041

4.817650637

Human target

neg_ctrl

ZFX

Random_1

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AGAGTGCGCTCT _A_Concatenation TATTAAAAGTGC _B

neg_ctrl

Target(s)

4.210264422

0.02293696

-2.178779714

0.008531041

4.817650637

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_202

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

Random_x_weak

ATGACCCCTTGT _A_Concatenation GGGAGTATGTCG _B

Target(s)

neg_ctrl

5.719757257

0.09831818

3.376466819

0.24054738

0.008531041

4.817650637

Human target

neg_ctrl

LEUTX

Random_4

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

Strong_X_random

CAGTGACATAGT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.633103951

0.23357818

6.961728472

0.00062691

6.014135995

0.070775661

4.806155772

0.098005281

Human target

Virus_target

EHMT2

hvTR_Q2HR71

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CATCTGAGTCGT _A_Concatenation ACTTGATGGTTT _B

pos_ctrl_A

Target(s)

0.514602955

0.00297531

-1.936876258

0.10515713

-5.433552896

0.157574718

4.778675958

0.120169648

vIRF2_VP64_pos_ctrl

Virus_target

RWY_VP16_vIRF2

hvTR_Q2HR73

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

vIRF2_VP64_pos_ctrl_X_mid

CTACGTGGCCCC _A_Concatenation GTTCCACGCCTG _B

Target(s)

Target(s)

1.746719742

5.37E-82

4.776255178

9.55E-07

-3.152487146

0.527905197

4.734938002

0.019978168

Virus_target

Human target

hvTR_Q2HR71

ZFX

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

Strong_X_strong

CGCCGGCATACA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.686467577

1.31E-10

4.62986365

0.01341224

-2.292600758

0.796218089

4.73466062

0.006506022

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268729.1_14

hvTR_Q2HR73

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

TAAAATTTATCA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.340331079

0.48494031

4.055025037

0.06313276

6.504154619

0.035023401

4.621186152

0.114829927

Human target

Virus_target

HSF1

hvTR_Q2HR71

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

AGCCGTGCTTGA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.575043791

5.18E-09

3.885897319

0.00081919

-4.869311352

0.159642332

4.580420429

0.07853916

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

hvTR_Q2HR71

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

Joint_ 3_A/u splice_ AGAGTGCGCTCT _b

neg_ctrl

neg_ctrl

-0.514511925

0.0391193

4.36437024

0.09576001

-4.145313298

0.276778688

4.557544939

0.053093786

neg_ctrl

neg_ctrl

Joint_3

Random_1

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Joint_X_random

CTCAGCGATATA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.056408024

0.94791391

2.765175233

0.1690105

5.928892386

0.147189779

4.526731112

0.211428465

Virus_target

Virus_target

hvTR_Q5Y0Q4

hvTR_Q2HR71

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

CTGCCGGTTGCG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.083963244

1.96E-29

4.082111304

5.02E-05

1.009824996

0.997690695

4.521248356

0.000437289

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

LEUTX

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GCAGATTCGAAT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.522836526

0.82433714

2.714505633

-4.679438388

4.4847972

Human target

neg_ctrl

AK9

Random_1

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CTACGTGGCCCC _A_Concatenation GCGAGGCAGACC _B

Target(s)

Target(s)

-0.581747506

0.37171203

-2.686570817

-7.910589289

0.037998675

4.43466331

0.218195585

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

Strong_x_unknown

CGCCGGCATACA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.592005368

0.7442977

2.482137414

0.14747479

-4.933713028

4.353122451

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268729.1_14

hvTR_Q2HR71

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ACTTGATGGTTT _A_Concatenation Joint_ 3_B

Target(s)

neg_ctrl

-0.684616958

3.10E-07

2.71765269

0.13687823

-5.222847873

0.15759116

4.323339925

0.149075572

Virus_target

neg_ctrl

hvTR_Q2HR73

Joint_3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

Mid_X_joint

AGAGTGCGCTCT _A_Concatenation ACAACGTGCATA _B

neg_ctrl

Target(s)

-0.119715682

0.88343822

-2.872423564

0.09697966

-4.945676675

0.291084293

4.287915513

0.218195585

neg_ctrl

Virus_target

Random_1

hvTR_P10407

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

Random_x_strong

ACTTTAGTAACA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.795019997

1.56E-13

2.337542575

0.05487336

4.553566667

0.190780897

4.267868557

0.084897118

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q69113

core_VP64_a

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CGATGGCGGAAT _B

neg_ctrl

Target(s)

2.379321465

0.29119771

-3.172461621

0.14019482

-1.529585356

4.249434651

neg_ctrl

Human target

Random_1

KIAA1586

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

Random_x_weak

ACTTGATGGTTT _A_Concatenation TCTTAGAGGGTG _B

Target(s)

Target(s)

-0.816754023

4.10E-15

2.416506618

0.02599406

-1.00954376

0.997690695

4.234655018

0.001244361

Virus_target

Human target

hvTR_Q2HR73

TRO

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

Mid_X_strong

AAACTTTGAGCG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.896167783

0.00180764

-4.589662802

0.00780178

5.182701598

0.121748841

4.200855522

0.121024915

Human target

Virus_target

ATF6B

hvTR_Q2HR71

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

Joint_1_A/u splice_ ACTTGATGGTTT _b

neg_ctrl

Target(s)

-1.321759131

0.23382733

5.374561966

-4.805853555

0.293964969

4.13584173

0.219085969

neg_ctrl

Virus_target

Joint_1

hvTR_Q2HR73

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Joint_X_mid

CATTAGTCCCGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.001723186

0.99110789

3.840432029

0.00021381

5.192558181

0.102803489

4.135044146

0.114829927

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P06930

core_VP64_a

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

TGATGAGCGCCC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.5606855

3.81E-07

4.882370118

5.26E-05

5.202123424

0.118326543

4.132686783

0.129741023

Human target

Virus_target

EEF1D

hvTR_Q2HR71

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

ATAACTCCACGC _A_Concatenation TAAAATTTATCA _B

pos_ctrl_A

Target(s)

-2.017912696

0.00656289

-7.129459616

1.79E-05

-4.75325373

0.224041844

4.12666021

0.15725643

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

HSF1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

vIRF2_VP64_pos_ctrl_X_mid

GTTCCACGCCTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.59342721

0.23227699

-4.850593119

4.70E-05

5.376784959

0.113496245

4.073639666

0.156896347

Human target

vIRF2_VP64_pos_ctrl

ZFX

core_VP64_a

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation GAGTGACCTATT _B

Target(s)

Target(s)

-1.212915259

0.00611211

-3.266828623

0.02354207

5.225630787

0.119647439

4.056596789

0.145553091

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

Strong_x_unknown

ATAACTCCACGC _A_Concatenation CGGCAATTGCTT _B

pos_ctrl_A

Target(s)

-0.886433135

0.82490703

-9.186465444

2.47975804

3.986325535

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q9QB93

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

vIRF2_VP64_pos_ctrl_X_mid

CTCAGCGATATA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.7946659

0.3917492

-4.364284668

0.01471201

4.567585339

0.376738345

3.947140588

0.280453332

Virus_target

neg_ctrl

hvTR_Q5Y0Q4

Random_1

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation CTCGCACCGAGG _B

pos_ctrl_A

Target(s)

0.038259789

0.94973077

-6.286238265

5.17E-06

5.406406776

0.102782462

3.91850514

0.170652887

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

vIRF2_VP64_pos_ctrl_X_mid

TCTATCACAACT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.250851938

0.92181589

4.155766861

0.00258074

-3.587807756

0.396424471

3.906218412

0.082429628

Human target

Virus_target

TOX4

hvTR_Q2HR71

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation GTACATACCGAA _B

neg_ctrl

Target(s)

-0.45901124

0.00909985

4.892300443

0.00064194

5.019730946

0.143201686

3.862706708

0.166769969

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

Random_x_mid

AATCGAGACCAG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-3.018473907

0.56300311

0.971871461

0.71938819

0.829279031

3.846699138

Virus_target

neg_ctrl

hvTR_Q8BB47

Random_1

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CCCGTAGGGGCT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.388035943

0.0391193

0.502144298

0.86913847

0.829279031

3.846699138

Human target

Virus_target

TET3

hvTR_Q2HR71

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ACTCGTGTTGTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.686695082

0.56169587

4.179516292

0.0883946

0.829279031

3.846699138

Virus_target

Virus_target

hvTR_Q9QB97

hvTR_Q2HR71

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATGACCCCTTGT _A_Concatenation TTCTAATTTCCT _B

Target(s)

Target(s)

0.513338906

0.84209077

-0.965969031

0.70600688

0.829279031

3.846699138

Human target

Human target

LEUTX

WDR76

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

Strong_X_strong

CTACGTGGCCCC _A_Concatenation TAAGATTCAACG _B

Target(s)

Target(s)

2.388360107

0.24325835

-0.787007754

0.73748128

0.829279031

3.846699138

Virus_target

Human target

hvTR_Q2HR71

ZNF292

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

Strong_X_strong

GTTCCACGCCTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.877386641

0.75207104

3.063860648

0.04159867

0.829279031

3.846699138

Human target

Human target

ZFX

LEUTX

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

GGCACAGCTCCA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.62755326

0.86342423

-0.693155365

0.80253436

0.281549106

3.818788286

Human target

Human target

DTX2

LEUTX

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

Stop-1_A/u splice_ CTACGTGGCCCC _b

neg_ctrl

Target(s)

0.683907776

0.86342423

1.168097043

0.66299712

0.281549106

3.818788286

neg_ctrl

Virus_target

Stop_1

hvTR_Q2HR71

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Termination_X_strong

AATCGAGACCAG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.995661307

0.80641597

-0.960540005

0.6995053

0.281549106

3.818788286

Virus_target

Human target

hvTR_Q8BB47

LEUTX

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AGCCATAAACCT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.362737289

0.86892322

-3.680463876

0.08080854

-4.985144597

0.235018356

3.815874487

0.240319952

Virus_target

Human target

hvTR_P03209

LEUTX

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGACAGCTCTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.107184315

0.00106928

2.222771652

-4.474190807

0.308007813

3.79551466

0.227978501

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

hvTR_Q2HR71

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATTTGTAGACCG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-2.95041379

0.12947864

-4.42781772

0.13874298

-0.232933756

3.790388015

Human target

Virus_target

MYCN

hvTR_Q2HR73

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GAGTGACCTATT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-4.296574815

0.03859914

-0.980159177

0.63235965

-0.232933756

3.790388015

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

LEUTX

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

ACTTGATGGTTT _A_Concatenation TTCTAATTTCCT _B

Target(s)

Target(s)

0.191073585

0.53702369

5.958282976

3.50E-05

4.521245673

0.221075186

3.769588171

0.166769969

Virus_target

Human target

hvTR_Q2HR73

WDR76

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

Mid_X_strong

ACTTGATGGTTT _A_Concatenation TGCCAGACGGTC _B

Target(s)

Target(s)

1.143390021

1.09E-31

3.417055602

0.00415692

-2.992769055

0.519811123

3.765361464

0.057793972

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P10541

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AAGGGTAAATTG _B

Target(s)

Target(s)

1.83968484

0.11077416

-0.927064695

0.56218914

-0.820792161

3.732955313

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q69513

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

Strong_X_mid

ATAACTCCACGC _A_Concatenation CATCTCACCTAG _B

pos_ctrl_A

Target(s)

-0.57261756

0.00120671

4.85596544

0.00976768

3.710777737

0.312984371

3.705480381

0.097385987

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P03206

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

vIRF2_VP64_pos_ctrl_X_mid

ACCAGTATTTAA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.308151321

0.52243449

1.063741737

0.55594745

-3.714882772

3.702358872

Human target

Virus_target

ARNTL2

hvTR_Q2HR71

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

GAGATTGTGTCC _A_Concatenation ATTTGTAGACCG _B

Target(s)

Target(s)

-0.139032733

0.77018502

4.981691653

0.00017155

4.592913464

0.199492182

3.641056831

0.185259163

Virus_target

Human target

hvTR_Q2HR71

MYCN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

Strong_X_mid

ATGACCCCTTGT _A_Concatenation CCAGACGGTCTG _B

Target(s)

Target(s)

2.027904962

9.34E-28

4.303894712

3.621857425

0.412917083

3.617434647

0.166769969

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

Strong_x_weak

GTACATACCGAA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.187917836

0.8328782

1.888354122

3.470299044

0.480471365

3.604969731

0.170492804

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

LEUTX

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation CCCTATGTTCTA _B

neg_ctrl

pos_ctrl_A

1.49162859

0.00035572

-4.847063634

0.09956659

-4.178763208

3.551565897

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_1

core_VP64_b

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

CAGTGACATAGT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.993927375

0.00011273

3.68919542

0.03872928

4.22307018

0.240423389

3.52421743

0.161820004

Human target

vIRF2_VP64_pos_ctrl

EHMT2

core_VP64_a

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation GATGGAGCTACA _B

Target(s)

Target(s)

-0.167795738

0.66495342

-2.557751966

0.2429528

-4.325988601

0.300125168

3.510619438

0.240710289

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P03209

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Mid_X_strong

CTACGTGGCCCC _A_Concatenation AATCGATCCTAC _B

Target(s)

Target(s)

0.503436447

0.36968355

-3.866815764

0.02599858

4.334605399

0.248335977

3.327977707

0.226429785

Virus_target

Human target

hvTR_Q2HR71

PRDM10

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

Strong_X_mid

ACTTTAGTAACA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.538014265

0.28696374

-0.597156974

0.75729949

-3.732806137

0.396731112

3.323510759

0.22237192

Virus_target

Virus_target

hvTR_Q69113

hvTR_Q2HR73

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ACTTGATGGTTT _A_Concatenation AAGACCGGTGCC _B

Target(s)

Target(s)

0.175128128

0.81658896

-1.994365446

0.10327598

1.769793744

0.899906723

3.288423147

0.083931183

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P08392

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

mid_X_mid

TATTAAAAGTGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.400837758

0.93141616

-3.112909338

0.32315075

0.992478895

3.265158543

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_202

LEUTX

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

AATGGCACTAGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.58686097

0.81782989

-0.71508607

0.74513376

0.992478895

3.265158543

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_024711.1_cds_YP_009052522.2_44

core_VP64_a

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation GCGAGGCAGACC _B

Target(s)

Target(s)

-1.11793553

3.54E-06

0.012481178

0.99447953

4.162533808

0.33827099

3.25963233

0.287660953

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

Mid_X_unknown

ACTTGATGGTTT _A_Concatenation TCTTGGTTTTGA _B

Target(s)

Target(s)

0.769503539

2.44E-06

3.629850618

0.04213749

2.712895042

0.580611989

3.258274325

0.098722329

Virus_target

Human target

hvTR_Q2HR73

ZNF597

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation CATTGTTTAAAT _B

neg_ctrl

Target(s)

-0.165624884

0.94311303

-4.768067996

0.17464411

-9.368168006

0.031295368

3.253545177

0.563387292

neg_ctrl

Human target

Random_1

POLR1E

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

Random_x_unknown

TACATGAGGCAC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-2.801505774

6.208085109

0.00919494

0.484522458

3.242086421

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

hvTR_Q2HR73

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATGACCCCTTGT _A_Concatenation CTCGCACCGAGG _B

Target(s)

Target(s)

5.334338063

4.83E-06

-4.745179292

0.13430239

0.039583014

3.225292967

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

Strong_X_mid

CTCGTTATGGCA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.26760315

0.28757726

-1.78658158

0.38421781

-2.568606871

3.219257258

Human target

neg_ctrl

NOVA1

Random_1

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ATGTGGCACGAC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-2.479464704

0.47019918

-2.181884034

-0.421182688

3.202325748

Human target

Human target

ANKRD17

LEUTX

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AATCGAGACCAG _B

Target(s)

Target(s)

1.041691665

0.80641597

4.04599926

0.2646259

-0.421182688

3.202325748

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q8BB47

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

Strong_X_strong

AGCCGTGCTTGA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.976808483

2.44E-21

4.108451372

0.00127782

-1.146836102

0.997690695

3.116594452

0.040651866

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

hvTR_Q2HR73

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

AATCAACGAGCA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.871013409

2.26E-29

5.450865513

7.96E-12

4.000179191

0.268392054

3.109190226

0.218195585

Human target

Virus_target

C2orf81

hvTR_Q2HR71

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATAACTCCACGC _A_Concatenation CGCCGGCATACA _B

pos_ctrl_A

Target(s)

-0.073923687

0.9134757

-1.115277239

0.5778329

-6.991681549

0.037311924

3.085206611

0.415694411

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_030656.1_cds_YP_009268729.1_14

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTGCCTCGGG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.16975091

0.938493

4.36045795

0.00212573

1.154823109

3.028913516

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

hvTR_Q2HR71

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTACGTGGCCCC _A_Concatenation TCAGCCGTAGGC _B

Target(s)

Target(s)

-0.378082808

0.27973193

-1.381398754

0.31960259

-3.700201318

0.323795032

3.014726614

0.219163182

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q805Y1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

Strong_X_mid

AAGACCGGTGCC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.019631021

0.9335834

2.187166732

0.26683465

3.667940257

0.290224196

2.963586337

0.191530223

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P08392

core_VP64_a

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTCACGACAAGA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.819056338

1.89E-05

0.784394255

0.66285666

3.748714601

0.303126826

2.93857917

0.230308643

Virus_target

Virus_target

hvTR_G3G929

hvTR_Q2HR71

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GATGGAGCTACA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.284700578

1.64E-06

5.999006799

0.00020202

3.347160245

0.402627999

2.881948626

0.218195585

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR71

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CCCTGCCTCGGG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.064058234

0.98432612

4.099458591

0.00142037

1.129691601

2.851363423

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

LEUTX

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CCCTGCCTCGGG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-2.824601962

0.03143968

4.216421835

0.00977601

1.129691601

2.851363423

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

hvTR_Q2HR73

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GAGATTGTGTCC _A_Concatenation GATCGCATGTTC _B

Target(s)

Target(s)

0.258232258

0.86342423

-5.123057585

0.053633

1.129691601

2.851363423

Virus_target

Human target

hvTR_Q2HR71

INPP4A

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

Strong_X_strong

ATGACCCCTTGT _A_Concatenation ACGGCGTAAGTA _B

Target(s)

Target(s)

4.044251705

0.47694407

1.129691601

2.851363423

Human target

Virus_target

LEUTX

cds_NC_025350.1_cds_YP_009094078.1_5

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

Strong_X_mid

CCGCCCTTATGT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.026849433

0.85660869

3.135899123

0.13957468

1.129691601

2.851363423

Human target

Human target

ZFX

LEUTX

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

TGCCAGACGGTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.49261486

0.18562008

3.427690683

0.00216231

-1.358256942

0.973675561

2.846787307

0.057793972

Virus_target

neg_ctrl

hvTR_P10541

Random_1

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AATGGCACTAGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.406732819

0.16187644

0.040678586

0.98246422

0.655817521

2.832620479

Virus_target

Human target

cds_NC_024711.1_cds_YP_009052522.2_44

LEUTX

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

AGAGTGCGCTCT _A_Concatenation TTAAATGAGGGC _B

neg_ctrl

Target(s)

5.410922784

0.000332

0.788259302

0.73748128

0.655817521

2.832620479

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

Random_x_mid

ATAACTCCACGC _A_Concatenation ATTTGTAGACCG _B

pos_ctrl_A

Target(s)

-0.732150776

0.00048411

2.326692873

0.27682961

4.371896356

0.190780897

2.810825069

0.292594387

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

MYCN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

vIRF2_VP64_pos_ctrl_X_mid

ACTTGATGGTTT _A_Concatenation CAACGCATGCCT _B

Target(s)

Target(s)

-0.491748446

0.00351418

5.908196143

0.00095831

0.795526954

0.997690695

2.78053389

0.04202036

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

Mid_X_weak

ACTTGATGGTTT _A_Concatenation GTTCCACGCCTG _B

Target(s)

Target(s)

0.765985135

0.00067751

4.739611242

0.00557968

-0.238324519

0.998501722

2.756572008

0.021401372

Virus_target

Human target

hvTR_Q2HR73

ZFX

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

Mid_X_strong

ACTTGATGGTTT _A_Concatenation TATCTATCGTGT _B

Target(s)

Target(s)

-0.820576812

0.00329937

1.869527104

0.48071279

1.245288911

0.983636094

2.755132062

0.065462272

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P03259

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AATGGCACTAGC _B

Target(s)

Target(s)

-0.298460187

0.58143595

2.179858975

0.27272364

3.335867578

0.421461462

2.677790533

0.286685424

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_024711.1_cds_YP_009052522.2_44

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

Strong_x_weak

CATCTGAGTCGT _A_Concatenation ATGACCCCTTGT _B

pos_ctrl_A

Target(s)

-0.619702452

0.22269773

1.222061042

0.33790827

-3.995654902

2.628440811

vIRF2_VP64_pos_ctrl

Human target

RWY_VP16_vIRF2

LEUTX

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VIRF2_VP64_pos strong_ctrl_x_strong

GGCACTGTCGAG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.908077241

0.09354755

-5.459935066

0.00071797

1.743595917

0.871241789

2.609300945

0.103147793

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P17147

core_VP64_a

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation CTCAGCGATATA _B

Target(s)

Target(s)

0.590311393

0.20781041

-5.328256146

0.00020202

3.463146968

0.412917083

2.582093793

0.341601869

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q5Y0Q4

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

Mid_X_strong

CTACGTGGCCCC _A_Concatenation CATTAGTCCCGC _B

Target(s)

Target(s)

-0.486997868

0.78182953

-0.454112557

0.76446307

0.806372848

2.514522765

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P06930

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

Strong_X_strong

ATAACTCCACGC _A_Concatenation CATCTGAGTCGT _B

pos_ctrl_A

pos_ctrl_A

-0.553105502

0.93202829

0.806372848

2.514522765

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_a

RWY_VP16_vIRF2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

ATCTCTCAGTTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.142176433

2.86E-08

0.068937282

0.96917964

-4.412719073

0.199492182

2.501595252

0.389216175

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

Random_1

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ATGACCCCTTGT _A_Concatenation TCTTAGAGGGTG _B

Target(s)

Target(s)

1.15879215

0.25462682

-0.379752003

0.78843818

3.56081307

2.498363969

Human target

Human target

LEUTX

TRO

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

Strong_X_strong

ACTTGATGGTTT _A_Concatenation CATCTGAGTCGT _B

Target(s)

pos_ctrl_A

1.131305308

0.44862406

3.959888493

0.00369217

3.129052409

2.413612329

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR73

RWY_VP16_vIRF2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

mid_X_vIRF2_VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation CTCCATTAATGA _B

pos_ctrl_A

Target(s)

0.244894981

0.43060539

-2.907944626

0.0451167

2.455805436

0.665320115

2.386820795

0.285422498

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q5IXR3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

VIRF2_VP64_pos ctrl_x_weak

TCTGTACCAACG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.12663374

0.09584462

-1.731980137

0.45128914

2.989888407

2.342631693

Virus_target

Virus_target

hvTR_Q6XA69

hvTR_Q2HR71

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

AATCAACGAGCA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.464791992

0.57948176

1.373632359

0.30699207

-4.903080206

0.113496245

2.306590113

0.405632218

Human target

Virus_target

C2orf81

hvTR_Q2HR71

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

GAGATTGTGTCC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.586179689

0.18896329

-1.582569745

0.23647027

2.919168286

0.527905197

2.299913468

0.346191512

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR71

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CGATGGCGGAAT _B

Target(s)

Target(s)

-5.742396689

0.05235126

3.88115205

1.353397139

2.267432068

Human target

Human target

LEUTX

KIAA1586

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

Strong_x_weak

ACGGCGTAAGTA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

7.198969509

1.353397139

2.267432068

Virus_target

neg_ctrl

cds_NC_025350.1_cds_YP_009094078.1_5

Random_1

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGTGACCTATT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.02687482

0.93141616

1.416967634

0.43395215

3.221274552

0.480471365

2.223844035

0.415614042

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

Random_1

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

ATGACCCCTTGT _A_Concatenation CTGCCGGTTGCG _B

Target(s)

Target(s)

-1.35934585

3.63E-12

-0.314377633

0.86457198

3.524896295

0.382791636

2.215090579

0.420144123

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

Strong_X_mid

ATGACCCCTTGT _A_Concatenation GTACATACCGAA _B

Target(s)

Target(s)

4.286139842

0.10711266

4.398446337

0.00732226

2.780471454

2.165172508

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

Strong_X_mid

TATCTATCGTGT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.303506842

0.39544886

-5.333119814

5.67E-05

3.673767162

0.518122906

2.131368901

0.570993876

Virus_target

Virus_target

hvTR_P03259

hvTR_Q2HR71

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

EPICXV.47-A\u splice_ CTACGTGGCCCC _b

pos_ctrl_A

Target(s)

-0.26277574

0.38876209

1.855481223

0.45128914

2.021471391

0.742836237

2.130010123

0.219085969

vIRF2_VP64_pos_ctrl

Virus_target

3x_vIRF2_core

hvTR_Q2HR71

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VIRF2_VP64_pos strong_ctrl_x_strong

AGAGTGCGCTCT _A_Concatenation CACACCCGGCAG _B

neg_ctrl

Target(s)

-1.13841797

3.66E-15

0.469241478

0.78352705

0.595014322

0.997690695

2.104947116

0.098005281

neg_ctrl

Virus_target

Random_1

hvTR_P19893

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

Random_x_strong

AGAGTGCGCTCT _A_Concatenation CCAGACGGTCTG _B

neg_ctrl

Target(s)

2.511508718

0.19157528

5.135854067

0.02389526

-2.724151175

2.098570724

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

Random_x_weak

ACTTGATGGTTT _A_Concatenation TACATGAGGCAC _B

Target(s)

Target(s)

-0.787774507

0.02419595

-6.09582715

7.36E-07

2.723003001

0.580611989

2.095151716

0.392765825

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

mid_X_mid

ATAACTCCACGC _A_Concatenation TCTTAGAGGGTG _B

pos_ctrl_A

Target(s)

0.285280071

0.11078803

1.26449008

0.41507208

0.769865197

0.997690695

2.073066391

0.100152293

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TRO

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation ACTTGATGGTTT _B

pos_ctrl_A

Target(s)

-0.8757395

0.01468232

-4.34284846

0.00016753

-2.929516439

0.492214467

2.021085227

0.391508113

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q2HR73

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

vIRF2_VP64_pos_ctrl_X_mid

TCTTGGTTTTGA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.370424575

0.93141616

1.785220715

0.56053958

-5.240903526

1.962881718

Human target

Human target

ZNF597

LEUTX

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation CCCCTTAGGAAT _B

neg_ctrl

Target(s)

0.038170676

0.9854934

-1.374515567

-1.845139475

1.948298595

neg_ctrl

Human target

Random_1

SYNE1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

Random_x_mid

Stop-1_A/u splice_ ATGACCCCTTGT _b

neg_ctrl

Target(s)

2.628901666

0.07185248

-2.225976796

0.35259645

0.771280844

1.940135541

neg_ctrl

Human target

Stop_1

LEUTX

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Termination_X_strong

ATGACCCCTTGT _A_Concatenation GCAACGAGGGTC _B

Target(s)

Target(s)

-0.81637252

0.54381256

1.960958855

-7.307013263

0.038338443

1.935711077

0.624474901

Human target

Human target

LEUTX

QRICH2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

Strong_X_mid

GAGATTGTGTCC _A_Concatenation GTTCCACGCCTG _B

Target(s)

Target(s)

0.322560522

0.81077083

0.226623032

0.89420679

-1.492746351

1.9290389

Virus_target

Human target

hvTR_Q2HR71

ZFX

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation CTCAGCGATATA _B

neg_ctrl

Target(s)

-0.496102858

0.29509007

-5.62000668

0.00022359

-2.636250542

0.772599368

1.854026899

0.590310725

neg_ctrl

Virus_target

Random_1

hvTR_Q5Y0Q4

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

Random_x_strong

TCAGCCGTAGGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.330611836

0.91324404

-5.186059459

0.09535537

1.559834265

1.852843232

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q805Y1

core_VP64_a

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation Joint_ 3_B

Target(s)

neg_ctrl

0.74798315

0.28354489

1.009977447

0.70600688

0.801134684

1.834237307

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

Strong-X-joint

ATGACCCCTTGT _A_Concatenation ATGACAAAACGA _B

Target(s)

Target(s)

-0.840770349

0.66495342

-1.487358169

0.41956458

-1.006281085

1.816027803

Human target

Virus_target

LEUTX

cds_NC_025350.1_cds_YP_009094074.1_1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

Strong_X_strong

ATAACTCCACGC _A_Concatenation ATTGTATCTAAC _B

pos_ctrl_A

Target(s)

-0.296462859

0.81690552

-4.56775436

0.02400653

-1.987769694

0.934700311

1.804004147

0.592785717

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

SMARCB1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

vIRF2_VP64_pos_ctrl_X_mid

TTAGTGCCATAC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.043136136

0.9854934

-0.235060283

0.9450104

-1.058941627

1.784784298

Human target

Human target

TET3

LEUTX

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CTACGTGGCCCC _A_Concatenation GAGACAGCTCTC _B

Target(s)

Target(s)

1.594312617

-5.606961687

0.1133452

-1.058941627

1.784784298

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

Strong_X_mid

CTACGTGGCCCC _A_Concatenation Joint_ 2_B

Target(s)

neg_ctrl

-1.026554704

1.20E-07

0.811184789

-2.286872555

0.856321281

1.774863257

0.592109514

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

Strong-X-joint

GACTGTGGGCGG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.766231411

0.57362051

2.27049263

-2.261842316

0.871139325

1.769498729

0.596765654

Human target

Virus_target

MON2

hvTR_Q2HR71

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation AGCCGTGCTTGA _B

neg_ctrl

Target(s)

-1.320950096

0.00047194

-2.415765785

0.25150303

2.430783956

0.653128487

1.76537836

0.454989974

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

Random_x_weak

ACTTGATGGTTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.095051795

0.00593454

6.082345537

0.00062813

-2.820291451

0.622197442

1.757865626

0.550384214

Virus_target

neg_ctrl

hvTR_Q2HR73

Random_1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ATAACTCCACGC _A_Concatenation CCAGACGGTCTG _B

pos_ctrl_A

Target(s)

-1.17156476

0.32392216

-3.341482748

0.03888733

-6.6462754

1.724130566

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

VIRF2_VP64_pos ctrl_x_weak

CAACGCATGCCT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-5.147769739

0.13847984

-0.449298295

1.651611873

1.683059042

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

hvTR_Q2HR71

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

AGAGTGCGCTCT _A_Concatenation CAGTGACATAGT _B

neg_ctrl

Target(s)

0.252101225

0.57019691

2.043095801

0.31917493

2.04868352

0.733105087

1.676660391

0.403335945

neg_ctrl

Human target

Random_1

EHMT2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

Random_x_mid

AGAGTGCGCTCT _A_Concatenation GCAGATTCGAAT _B

neg_ctrl

Target(s)

1.569816337

1.09E-06

5.862600612

4.46E-05

-3.833339407

0.396731112

1.671872655

0.627531443

neg_ctrl

Human target

Random_1

AK9

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

Random_x_mid

TCTATCACAACT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.005722971

0.76595865

4.951823357

6.38E-05

0.907014646

1.666358022

Human target

Human target

TOX4

LEUTX

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AAAACAAGCATT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.678116244

0.82936061

3.124973587

0.01033701

0.597180359

1.659069326

Virus_target

Human target

cds_NC_030656.1_cds_YP_009268803.1_88

LEUTX

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

TGCCAGACGGTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.293118193

0.50685675

3.971010231

0.00057613

0.923529399

0.997690695

1.657865275

0.290813651

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P10541

core_VP64_a

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CATGCTAACACC _B

neg_ctrl

Target(s)

-0.832451113

0.09668495

-3.049324274

0.02473656

-3.215563428

0.572967985

1.642138635

0.624474901

neg_ctrl

Virus_target

Random_1

hvTR_F5HCV3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

Random_x_strong

CGCCGGCATACA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.750271117

0.66087705

-1.172515467

0.54837089

-0.238223872

1.638165971

Virus_target

neg_ctrl

cds_NC_030656.1_cds_YP_009268729.1_14

Random_1

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation GAGATTGTGTCC _B

pos_ctrl_A

Target(s)

-0.453424726

0.15482312

-3.734576005

0.00062712

2.61206827

0.570766083

1.63695875

0.472641252

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q2HR71

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VIRF2_VP64_pos strong_ctrl_x_strong

CTACGTGGCCCC _A_Concatenation Joint_ 1_B

Target(s)

neg_ctrl

0.422626019

0.10004367

5.341492676

0.00732226

2.614882056

0.551036114

1.631748809

0.464627066

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

Strong-X-joint

GAGATTGTGTCC _A_Concatenation ATCCAATCTGTG _B

Target(s)

Target(s)

7.278730575

0.09988704

-1.159549692

1.614731197

Virus_target

Human target

hvTR_Q2HR71

GLI2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

Strong_X_mid

TGGCCCCCAGTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.904613291

0.0471767

-1.873737773

-1.813911177

0.877171774

1.587469807

0.530917523

Virus_target

Virus_target

hvTR_Q3I8P6

hvTR_Q2HR71

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

ATGACCCCTTGT _A_Concatenation GATCGCATGTTC _B

Target(s)

Target(s)

-1.596864885

0.22734303

-5.78884547

0.09686773

-2.441116307

0.803891096

1.582442664

0.626950374

Human target

Human target

LEUTX

INPP4A

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

Strong_X_strong

ACTTGATGGTTT _A_Concatenation TAAGATTCAACG _B

Target(s)

Target(s)

-0.805030025

2.80E-07

2.121866298

0.21085724

2.150072676

0.703227418

1.559220448

0.464627066

Virus_target

Human target

hvTR_Q2HR73

ZNF292

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

Mid_X_strong

GCGAGGCAGACC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

5.642547402

0.0003937

-2.914520999

0.34689881

-4.611193359

1.51879336

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

Random_1

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

CCCTATGTTCTA _A_Concatenation ACTTGATGGTTT _B

pos_ctrl_A

Target(s)

0.578763744

0.3372476

-1.822983312

0.40695666

-0.083392029

1.494846927

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q2HR73

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

vIRF2_VP64_pos_ctrl_X_mid

AGAGTGCGCTCT _A_Concatenation AATCGAGACCAG _B

neg_ctrl

Target(s)

-2.136686854

0.36741802

3.88115205

-3.576130805

1.480121133

neg_ctrl

Virus_target

Random_1

hvTR_Q8BB47

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

Random_x_strong

AGAGTGCGCTCT _A_Concatenation GTTCCACGCCTG _B

neg_ctrl

Target(s)

1.643484139

0.01377271

5.233804227

0.03194613

-1.276640569

0.997690695

1.476252889

0.635919588

neg_ctrl

Human target

Random_1

ZFX

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

Random_x_strong

ACCAGTATTTAA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.05269266

0.97860685

-0.806002169

0.68982791

-1.716422214

0.973675561

1.437745384

0.67077053

Human target

neg_ctrl

ARNTL2

Random_1

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation GCAACGAGGGTC _B

pos_ctrl_A

Target(s)

-2.788699662

0.09831989

-4.779729483

0.13221889

-3.257361161

1.435611111

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

QRICH2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

vIRF2_VP64_pos_ctrl_X_mid

AGAGTGCGCTCT _A_Concatenation ATTGTATCTAAC _B

neg_ctrl

Target(s)

-0.430525729

0.54236082

-2.615777984

0.08383374

-4.244127073

1.433600852

neg_ctrl

Human target

Random_1

SMARCB1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

Random_x_mid

GATCGCATGTTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.606613267

0.00328682

-0.175093739

0.9356323

1.908274962

0.799861834

1.388557076

0.510873375

Human target

neg_ctrl

INPP4A

Random_1

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

TGGCCCCCAGTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.353844748

0.92647166

-3.820627393

0.07411668

1.093111598

1.379923139

Virus_target

Human target

hvTR_Q3I8P6

LEUTX

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation AGCCATAAACCT _B

Target(s)

Target(s)

0.252568733

0.08334253

3.052988166

0.07667512

2.205545125

0.693965883

1.378849411

0.550384214

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P03209

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

mid_X_mid

CTACGTGGCCCC _A_Concatenation CTGCCGGTTGCG _B

Target(s)

Target(s)

0.085749267

0.71380818

5.292689342

5.90E-05

2.253234571

0.662355132

1.360765443

0.539565192

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

Strong_X_mid

CATTGTTTAAAT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.205949217

0.45505484

1.371913546

0.29899332

2.482402356

0.634646987

1.347132723

0.590310725

Human target

Virus_target

POLR1E

hvTR_Q2HR71

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

ATGACCCCTTGT _A_Concatenation GCGAGGCAGACC _B

Target(s)

Target(s)

0.69807194

0.49872084

-5.906454068

0.00109019

-4.042323036

1.344013415

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

Strong_x_unknown

CTACGTGGCCCC _A_Concatenation AAGACCGGTGCC _B

Target(s)

Target(s)

0.203400124

0.70546103

-0.396322981

0.7912345

-1.814459373

0.870358589

1.301893593

0.585780662

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P08392

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

Strong_X_mid

TCAGCCGTAGGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.893242587

0.74390166

-5.324706757

0.07672334

-3.351472084

1.298388752

Virus_target

Virus_target

hvTR_Q805Y1

hvTR_Q2HR71

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation GGCACAGCTCCA _B

neg_ctrl

Target(s)

0.053532743

0.94919394

-5.131921353

0.04653661

-1.45795715

1.278378412

neg_ctrl

Human target

Random_1

DTX2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

Random_x_unknown

GGGAGTATGTCG _A_Concatenation ATGACCCCTTGT _B

neg_ctrl

Target(s)

-0.414059452

0.82490703

-3.465513926

0.1566422

1.889855634

1.268290505

neg_ctrl

Human target

Random_4

LEUTX

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Random_x_strong

TCTTGGTTTTGA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.748975568

0.63450624

-0.576022665

0.84184156

1.889855634

1.268290505

Human target

Virus_target

ZNF597

hvTR_Q2HR71

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATCCAATCTGTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.276785654

0.92803153

1.677139367

0.52530556

1.527207005

1.261510004

Human target

vIRF2_VP64_pos_ctrl

GLI2

core_VP64_a

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation CATCTGAGTCGT _B

Target(s)

pos_ctrl_A

1.103046079

0.75590178

6.003290442

0.00156378

0.155435055

1.233550505

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

RWY_VP16_vIRF2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

Strong_X_vIRF2\u VP64_pos_ctrl

GGCACTGTCGAG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.164326593

0.87740996

-0.139158719

0.93504853

-2.130469701

0.868917591

1.2121708

Virus_target

Virus_target

hvTR_P17147

hvTR_Q2HR71

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

GGCACAGCTCCA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.931126466

0.45350915

-3.299251973

0.17069892

-2.028819151

0.889535073

1.205638706

0.709382773

Human target

Virus_target

DTX2

hvTR_Q2HR73

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

ACGACTCACCGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.626838612

0.77928478

-1.780368738

0.50177205

5.393327339

1.189503102

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

hvTR_Q2HR71

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ACTTGATGGTTT _A_Concatenation CTCGTTATGGCA _B

Target(s)

Target(s)

-0.48463759

0.03338662

4.819915517

0.02400653

2.570597492

0.580611989

1.179282647

0.630780636

Virus_target

Human target

hvTR_Q2HR73

NOVA1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

mid_X_mid

ACTTGATGGTTT _A_Concatenation TTTAACGGATTG _B

Target(s)

Target(s)

-0.72796167

0.09988704

-4.322471153

0.0016933

1.739365194

0.81934659

1.178331688

0.518744839

Virus_target

Human target

hvTR_Q2HR73

TWIST2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

mid_X_mid

GAGATTGTGTCC _A_Concatenation CGCCGGCATACA _B

Target(s)

Target(s)

-1.841517505

0.18334753

-3.012320806

0.29907275

0.131118399

1.162103585

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_030656.1_cds_YP_009268729.1_14

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

Strong_X_strong

GGCACTGTCGAG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.392592625

0.81690552

-1.713889714

0.25252688

-1.200648001

1.151663367

Virus_target

Human target

hvTR_P17147

LEUTX

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

CATCTCACCTAG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.709763226

0.38922543

1.683764643

0.29264921

-5.327828084

1.147081827

Virus_target

Virus_target

hvTR_P03206

hvTR_Q2HR73

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TGATGAGCGCCC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.239696748

0.4737404

3.174959234

2.998050861

0.418960654

1.14289441

0.64853834

Human target

vIRF2_VP64_pos_ctrl

EEF1D

core_VP64_a

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation AAGACCGGTGCC _B

pos_ctrl_A

Target(s)

0.626467073

1.20E-05

5.370664311

1.17E-05

1.6634717

0.877171774

1.101933069

0.608816077

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P08392

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

vIRF2_VP64_pos_ctrl_X_mid

CTACGTGGCCCC _A_Concatenation GTACATACCGAA _B

Target(s)

Target(s)

0.865349217

0.28726554

0.256244147

0.85890913

1.382022645

1.097597554

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

Strong_X_mid

ATGACCCCTTGT _A_Concatenation TTAAATGAGGGC _B

Target(s)

Target(s)

0.384212959

0.85884337

-4.437953639

0.05552114

-0.913137641

1.095276065

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

Strong_X_mid

ACAACGTGCATA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.659961567

6.37E-23

-0.57384925

0.74513376

2.168025058

0.703227418

1.084864637

0.638579701

Virus_target

Human target

hvTR_P10407

LEUTX

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

GAGATTGTGTCC _A_Concatenation Joint_ 1_B

Target(s)

neg_ctrl

0.17739503

0.82429662

5.299274559

0.00940756

-1.684738002

0.976975145

1.079151833

0.760804824

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

Strong-X-joint

Joint_ 2_A/u splice_ ATAACTCCACGC _b

neg_ctrl

pos_ctrl_A

0.987791077

0.04916082

4.018063296

0.09317132

0.352906907

1.015782106

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_2

core_VP64_a

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Linker_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation CTGCCGGTTGCG _B

Target(s)

Target(s)

-0.992557612

4.96E-10

2.120892066

0.23767729

1.242663962

0.95807515

0.937064178

0.566175704

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

mid_X_mid

ATAACTCCACGC _A_Concatenation GGCACTGTCGAG _B

pos_ctrl_A

Target(s)

-0.248775848

0.82544101

-5.978185565

0.00029864

-2.094607356

0.798947013

0.912854627

0.72964861

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P17147

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

VIRF2_VP64_pos ctrl_x_unknown

CTGCCGGTTGCG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.11970577

7.45E-18

3.136645504

0.01719167

2.253016506

0.665320115

0.908504475

0.700036819

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

hvTR_Q2HR71

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ACTTGATGGTTT _A_Concatenation ATGTGGCACGAC _B

Target(s)

Target(s)

-0.256266476

0.36743075

-3.778187384

0.00259259

1.169081055

0.983636094

0.888162231

0.655523139

Virus_target

Human target

hvTR_Q2HR73

ANKRD17

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

mid_X_mid

CCTAAATGCAAG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-5.010681713

-1.629306057

0.877388115

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025410.1_cds_YP_009094498.1_7

core_VP64_a

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

AGTTGCTTTGCT _A_Concatenation ATAACTCCACGC _B

neg_ctrl

pos_ctrl_A

0.960333021

0.00488169

4.179882546

0.06702671

2.282660606

0.704006661

0.855220278

0.745418229

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_2

core_VP64_a

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Random_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation Joint_ 2_B

neg_ctrl

neg_ctrl

1.299477087

0.12232448

-4.409678395

0.14518028

2.145491451

0.853443827

neg_ctrl

neg_ctrl

Random_1

Joint_2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

Random_X_joint

ATAACTCCACGC _A_Concatenation AGCCGTGCTTGA _B

pos_ctrl_A

Target(s)

0.539193025

0.81666774

-2.90652737

0.42930651

1.456980834

0.843830764

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

VIRF2_VP64_pos ctrl_x_weak

CTCACGACAAGA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.514506396

0.57736265

2.139412733

0.04463366

-0.346964688

0.841973254

Virus_target

Human target

hvTR_G3G929

LEUTX

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AAAACAAGCATT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.742604782

2.42E-51

4.464018864

5.18E-06

2.54870469

0.574934744

0.839688459

0.734717606

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_030656.1_cds_YP_009268803.1_88

core_VP64_a

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation GATGGAGCTACA _B

Target(s)

Target(s)

1.879945463

0.60940534

1.895753735

0.61426979

-3.877100388

0.822271134

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03209

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Strong_X_strong

GGCACAGCTCCA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.779855302

0.48649146

-5.062641363

0.15596426

-2.334841399

0.812865607

Human target

vIRF2_VP64_pos_ctrl

DTX2

core_VP64_a

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation ATTTGTAGACCG _B

Target(s)

Target(s)

-0.533841416

0.42460236

7.563147751

0.00295321

-1.889450945

0.770864826

Virus_target

Human target

hvTR_Q2HR71

MYCN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

Strong_X_mid

CTGGTAGTTGTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.76744908

0.46430133

2.09584397

0.4070014

0.563208724

0.748168124

Virus_target

Virus_target

hvTR_F6KS47

hvTR_Q2HR73

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

GACTGTGGGCGG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.520269235

0.65676761

-4.732085826

0.04424815

-4.065153722

0.723617846

Human target

Virus_target

MON2

hvTR_Q2HR73

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTCGTTATGGCA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.243346555

0.82429662

-2.934683909

0.0608294

-1.101450716

0.997690695

0.631504535

0.780883772

Human target

vIRF2_VP64_pos_ctrl

NOVA1

core_VP64_a

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CATTAGTCCCGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.170138862

0.8780525

4.042905152

0.10604816

-1.478634957

0.997690695

0.628296376

0.886599957

Virus_target

neg_ctrl

hvTR_P06930

Random_1

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CTACGTGGCCCC _A_Concatenation Stop_1_B

Target(s)

neg_ctrl

-2.099795004

0.07250322

4.820861222

0.00113014

-7.036155021

0.562653541

Virus_target

neg_ctrl

hvTR_Q2HR71

Stop_1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

Strong_X_termination

AATCGATCCTAC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.884048604

0.11925871

-0.474312793

0.75805561

-0.919399756

0.997690695

0.554388365

0.896063592

Human target

Virus_target

PRDM10

hvTR_Q2HR73

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GAGATTGTGTCC _A_Concatenation Joint_ 3_B

Target(s)

neg_ctrl

0.089154207

0.96035322

-5.797785961

0.01745071

-4.0227046

0.508387958

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

Strong-X-joint

ATAACTCCACGC _A_Concatenation AGCCATAAACCT _B

pos_ctrl_A

Target(s)

1.68124465

1.87E-16

1.245080785

0.53051558

2.136151821

0.72394284

0.506541254

0.844904201

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P03209

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

vIRF2_VP64_pos_ctrl_X_mid

GTACATACCGAA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.162739642

0.00974837

-5.809727442

0.02989572

-1.373836194

0.469619153

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

core_VP64_a

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation TACATGAGGCAC _B

pos_ctrl_A

Target(s)

-1.716170231

0.49700987

-5.58970336

0.03888733

-5.358663263

0.4397358

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

vIRF2_VP64_pos_ctrl_X_mid

GGTGTCTCGATT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.160633748

0.95787851

1.414931716

0.65265206

-0.421640427

0.427016738

Human target

neg_ctrl

E2F5

Random_1

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CAGTGACATAGT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.611972011

0.0863072

5.915686221

1.23E-07

3.17543956

0.570391548

0.410116426

0.914216659

Human target

Virus_target

EHMT2

hvTR_Q2HR71

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ACAACGTGCATA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.261835701

0.16937431

1.139745633

0.52277462

-2.699154352

0.574934744

0.366152286

0.902237344

Virus_target

Virus_target

hvTR_P10407

hvTR_Q2HR71

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

TCAGCCGTAGGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.061666538

0.92304294

4.087446849

0.05018079

2.63742964

0.572967985

0.354484472

0.902200589

Virus_target

Human target

hvTR_Q805Y1

LEUTX

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGATTGTGTCC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.113009742

0.90763615

-5.019686845

0.00062712

-1.710539097

0.335420581

Virus_target

Human target

hvTR_Q2HR71

LEUTX

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

TCAGCCGTAGGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.360042349

0.86342423

-3.157670546

0.2632007

2.159648733

0.326515198

Virus_target

neg_ctrl

hvTR_Q805Y1

Random_1

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ATAACTCCACGC _A_Concatenation TGGCCCCCAGTT _B

pos_ctrl_A

Target(s)

-0.84476964

0.04064654

-5.862623718

0.00628323

-5.840837533

0.324426966

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q3I8P6

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

VIRF2_VP64_pos ctrl_x_weak

TATCGCAAGAAC _A_Concatenation AGAGTGCGCTCT _B

neg_ctrl

neg_ctrl

-0.757692055

0.3372476

2.584470563

0.05968663

-0.90213542

0.997690695

0.32012067

0.90076366

neg_ctrl

neg_ctrl

Random_5

Random_1

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Random_x_random

Stop 2_A splice ATAACTCCACGC B

neg_ctrl

pos_ctrl_A

0.094261317

0.97488974

-2.450279355

0.35394249

0.703495589

0.318382535

neg_ctrl

vIRF2_VP64_pos_ctrl

Stop_2

core_VP64_a

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Termination_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CAACGCATGCCT _B

neg_ctrl

Target(s)

-0.480443301

0.06765358

3.100307847

0.08071342

1.54805731

0.874190583

0.30577931

0.886599957

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

Random_x_weak

AGAGTGCGCTCT _A_Concatenation GGAGGCACATCG _B

neg_ctrl

Target(s)

1.081687677

1.43E-11

-2.285993278

0.06080289

-2.376746642

0.679495956

0.257043229

0.935730193

neg_ctrl

Virus_target

Random_1

hvTR_Q87042

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

Random_x_strong

AGAGTGCGCTCT _A_Concatenation Joint_ 3_B

neg_ctrl

neg_ctrl

-0.898845443

0.45084025

-2.115347339

0.32894908

-0.228118001

0.243328485

neg_ctrl

neg_ctrl

Random_1

Joint_3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

Random_X_joint

AGTTGCTTTGCT _A_Concatenation GAGATTGTGTCC _B

neg_ctrl

Target(s)

0.080791763

0.89675803

4.036457438

0.04816017

-1.12100915

0.222740188

neg_ctrl

Virus_target

Random_2

hvTR_Q2HR71

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Random_x_strong

CTGCCGGTTGCG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.737752278

0.02638198

1.831779963

0.12197421

-1.051036938

0.217808708

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

Random_1

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGATTGTGTCC _A_Concatenation ACGACTCACCGC _B

Target(s)

Target(s)

-0.47922872

0.81690552

-0.44799202

0.89519343

-0.934007198

0.213884808

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

Strong_X_mid

CATCTGAGTCGT _A_Concatenation ATAACTCCACGC _B

pos_ctrl_A

pos_ctrl_A

-0.689048446

0.04776592

4.327088726

0.04160686

1.204366126

0.987041604

0.212151908

0.93924838

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

RWY_VP16_vIRF2

core_VP64_a

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

AATCGAGACCAG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.195139581

0.94919394

-4.040795247

0.20134294

-2.139599531

0.14022633

Virus_target

Virus_target

hvTR_Q8BB47

hvTR_Q2HR71

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

AGCCATAAACCT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.335474845

0.00662615

0.413686103

0.82720717

1.76117014

0.851559334

0.128474535

0.965824722

Virus_target

neg_ctrl

hvTR_P03209

Random_1

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

Joint_1_A/u splice_ AGAGTGCGCTCT _b

neg_ctrl

neg_ctrl

-1.397055722

0.00091978

-3.090284227

0.11336437

-1.836287723

0.125706013

neg_ctrl

neg_ctrl

Joint_1

Random_1

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Joint_X_random

AATCGAGACCAG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.392271569

1.18E-09

-4.967798742

0.00095831

-2.001250125

0.934152898

0.122258859

0.9828278

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q8BB47

core_VP64_a

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation AGAGTGCGCTCT _B

neg_ctrl

neg_ctrl

-0.652574893

0.00010169

5.475209909

0.00011897

1.462798649

0.934700311

0.117179463

0.967254711

neg_ctrl

neg_ctrl

Random_1

Random_1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Random_x_random

CTGGTAGTTGTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.391395516

0.35312215

4.386002441

0.09576001

-0.141091018

0.112611664

Virus_target

neg_ctrl

hvTR_F6KS47

Random_1

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

ACTTGATGGTTT _A_Concatenation TCAGCCGTAGGC _B

Target(s)

Target(s)

-0.059231035

0.86342423

3.911686692

0.02595648

-0.26616897

0.997690695

0.098479384

0.945626709

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q805Y1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

mid_X_mid

ACTTTAGTAACA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.059370341

8.92E-05

-0.743398989

0.66003866

-2.506505199

0.529778264

0.092808267

0.976901733

Virus_target

neg_ctrl

hvTR_Q69113

Random_1

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AGAGTGCGCTCT _A_Concatenation ACTTTAGTAACA _B

neg_ctrl

Target(s)

-0.193717483

0.86892322

-4.87696204

0.00080119

-0.802988013

0.997690695

0.0914227

0.984564542

neg_ctrl

Virus_target

Random_1

hvTR_Q69113

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

Random_x_strong

GAGATTGTGTCC _A_Concatenation TTTAACGGATTG _B

Target(s)

Target(s)

0.276464599

0.31988807

1.676533763

0.42930651

-1.439547247

0.976975145

0.023950238

0.995060651

Virus_target

Human target

hvTR_Q2HR71

TWIST2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CAGTGACATAGT _B

Target(s)

Target(s)

-0.31658724

0.12953115

3.97371437

0.05973494

0.769564213

0.997690695

0.02075425

0.994766086

Virus_target

Human target

hvTR_Q2HR71

EHMT2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

Strong_X_mid

ATAACTCCACGC _A_Concatenation CATGCTAACACC _B

pos_ctrl_A

Target(s)

1.068462573

4.06E-07

-0.742993487

0.63897552

-4.09225671

0.013589008

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_F5HCV3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

VIRF2_VP64_pos strong_ctrl_x_strong

AGAGTGCGCTCT _A_Concatenation ATGTGGCACGAC _B

neg_ctrl

Target(s)

-0.783154462

5.17E-09

5.748255934

6.38E-05

1.080153366

0.995270541

0.002579356

0.999421067

neg_ctrl

Human target

Random_1

ANKRD17

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

Random_x_mid

GGCCTTTCGGGC _A_Concatenation ATAACTCCACGC _B

neg_ctrl

pos_ctrl_A

0.517537679

0.50380671

2.711006308

0.25363982

-5.348540709

0.097296843

0.00182921

0.999421067

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_3

core_VP64_a

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Random_X_vIRF2\u VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation EPICXV.47_B

pos_ctrl_A

pos_ctrl_A

-0.332998303

0.91326182

4.420985537

0.00989082

-0.813179645

-0.010122676

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_a

3x_vIRF2_core

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation ATGTGGCACGAC _B

Target(s)

Target(s)

0.691722946

5.51E-10

5.89700202

3.58E-05

0.613011962

0.997690695

-0.017156043

0.994766086

Virus_target

Human target

hvTR_Q2HR71

ANKRD17

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

Strong_X_mid

CTACGTGGCCCC _A_Concatenation TGCCAGACGGTC _B

Target(s)

Target(s)

0.549526056

4.88E-05

4.63418439

0.01582874

0.983350079

0.997690695

-0.029300373

0.994766086

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P10541

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

Strong_X_strong

ATAACTCCACGC _A_Concatenation ACGACTCACCGC _B

pos_ctrl_A

Target(s)

6.286576616

0.02699935

-4.342195826

-0.030366742

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

vIRF2_VP64_pos_ctrl_X_mid

ACCAGTATTTAA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.112221946

0.84320905

-4.749563692

0.00157575

-2.445065888

-0.036281135

Human target

Virus_target

ARNTL2

hvTR_Q2HR73

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CTCACGACAAGA _B

Target(s)

Target(s)

0.931010243

0.23382858

-3.016944751

0.31825647

-1.742040783

0.834609851

-0.04110902

0.991112506

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_G3G929

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

Strong_X_strong

GGTGTCTCGATT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.541075193

0.85681444

-3.27242354

0.10515713

-0.571425044

-0.052307818

Human target

Virus_target

E2F5

hvTR_Q2HR73

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation CTCACGACAAGA _B

neg_ctrl

Target(s)

-0.178603315

0.92304294

-1.517718004

0.56218914

0.335921396

-0.083908871

neg_ctrl

Virus_target

Random_1

hvTR_G3G929

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

Random_x_strong

GGAGGCACATCG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.714079894

0.03148891

2.108369794

-0.82241016

0.997690695

-0.106665771

0.9828278

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q87042

core_VP64_a

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation CGATGGCGGAAT _B

Target(s)

Target(s)

0.600807126

0.38377703

-4.950844438

0.0050302

-4.863285093

-0.127964546

Virus_target

Human target

hvTR_Q2HR71

KIAA1586

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

Strong_x_weak

ATAACTCCACGC _A_Concatenation CGATGGCGGAAT _B

pos_ctrl_A

Target(s)

-1.754898375

0.21779974

-0.920756691

-0.168883587

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

KIAA1586

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

VIRF2_VP64_pos ctrl_x_weak

CTCCATTAATGA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.385870044

2.554413976

-2.362808482

-0.170160959

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q5IXR3

core_VP64_a

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

CCCCTTAGGAAT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

4.484705094

0.32767348

8.501950322

-2.362808482

-0.170160959

Human target

neg_ctrl

SYNE1

Random_1

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGATTGTGTCC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.486517931

0.72790325

0.156060376

0.9459521

-0.107144781

0.998501722

-0.200237849

0.965824722

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

core_VP64_a

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGTTAGGCTCTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.141306938

0.63664962

-1.490740112

0.36520524

1.457711023

0.953105946

-0.201144741

0.942416038

Human target

Virus_target

TOX4

hvTR_Q2HR73

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CCCTGCCTCGGG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.68966899

4.07E-06

5.897720999

8.78E-05

0.85935825

0.997690695

-0.207686513

0.926981938

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

core_VP64_a

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATGTGGCACGAC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.364933259

0.05848158

-3.126889817

0.15035859

-0.613171562

-0.258277926

Human target

neg_ctrl

ANKRD17

Random_1

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ATGACCCCTTGT _A_Concatenation ACTCGTGTTGTC _B

Target(s)

Target(s)

-2.442645515

0.01342291

-1.478045212

0.54946476

-2.428403109

-0.260370546

Human target

Virus_target

LEUTX

hvTR_Q9QB97

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

Strong_X_mid

ACTTGATGGTTT _A_Concatenation TGGCCCCCAGTT _B

Target(s)

Target(s)

1.387311323

0.36774226

-2.981801614

-2.428403109

-0.260370546

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q3I8P6

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

Mid_X_weak

GTCACCCTCCTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-2.097944489

0.74855254

3.88115205

2.904704451

-0.275553032

Human target

neg_ctrl

E2F5

Random_1

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AGAGTGCGCTCT _A_Concatenation ACCAGTATTTAA _B

neg_ctrl

Target(s)

-0.73590366

0.22130449

-2.300065395

0.24997751

-2.748593362

-0.279935607

neg_ctrl

Human target

Random_1

ARNTL2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Random_x_strong

CCCCTTAGGAAT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.347779795

0.91132524

-2.490667222

0.48071279

-1.522913448

-0.295047465

Human target

Virus_target

SYNE1

hvTR_Q2HR73

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATGACCCCTTGT _A_Concatenation AAGGGTAAATTG _B

Target(s)

Target(s)

-0.360341085

0.90321028

-0.628257587

0.66139704

2.933317005

-0.31618873

Human target

Virus_target

LEUTX

hvTR_Q69513

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

Strong_X_mid

ATTGTATCTAAC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.087801008

0.05235126

6.106084435

0.00302307

-0.865377123

-0.336151454

Human target

Virus_target

SMARCB1

hvTR_Q2HR71

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CAACGCATGCCT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-2.03842623

0.51097628

1.354700976

0.50111097

-1.988184763

-0.341075036

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

hvTR_Q2HR71

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

GATCGCATGTTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.624424336

0.40044407

0.161667261

0.93840513

0.396431551

-0.345782092

Human target

Virus_target

INPP4A

hvTR_Q2HR71

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TAAAATTTATCA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.08880035

0.81666774

-3.067747497

0.01582874

-0.629781979

0.997690695

-0.351769659

0.911245907

Human target

vIRF2_VP64_pos_ctrl

HSF1

core_VP64_a

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTCACGACAAGA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.963899763

7.63E-05

5.256478517

2.17E-05

0.793255316

0.997690695

-0.359903757

0.843761696

Virus_target

Virus_target

hvTR_G3G929

hvTR_Q2HR71

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

GAGATTGTGTCC _A_Concatenation ATGTGGCACGAC _B

Target(s)

Target(s)

-0.00554909

0.9798201

5.397531899

0.00017431

0.394962514

0.997690695

-0.362974985

0.8188018

Virus_target

Human target

hvTR_Q2HR71

ANKRD17

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

Strong_X_mid

CTACGTGGCCCC _A_Concatenation ACAACGTGCATA _B

Target(s)

Target(s)

0.430920452

0.0015992

-1.086534391

-1.106282821

0.997690695

-0.371166087

0.90076366

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P10407

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

Strong_X_strong

GATCGCATGTTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.869099538

0.00611211

-4.11735085

0.00047339

-0.80604411

0.997690695

-0.398308047

0.884436889

Human target

Virus_target

INPP4A

hvTR_Q2HR71

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

EPICXV.47-A\u splice_ ATAACTCCACGC _b

pos_ctrl_A

pos_ctrl_A

-0.21974086

0.76101183

-6.281369053

0.00151048

-0.454561794

-0.424127461

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

3x_vIRF2_core

core_VP64_a

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation GCAACGAGGGTC _B

Target(s)

Target(s)

1.128526586

5.43E-07

-3.886049763

0.00162533

-1.657071747

0.968300879

-0.453067541

0.90076366

Virus_target

Human target

hvTR_Q2HR71

QRICH2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

Strong_X_mid

GAGACAGCTCTC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.081207344

0.9335834

-0.317415485

0.8725678

-2.686682065

-0.457430856

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

hvTR_Q2HR71

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

GAGATTGTGTCC _A_Concatenation GGGAGTATGTCG _B

Target(s)

neg_ctrl

-0.834909843

0.53101873

-1.472381741

0.65881785

-2.079525128

-0.460070369

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_4

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

Strong_X_random

Joint_1_A/u splice_ GAGATTGTGTCC _b

neg_ctrl

Target(s)

0.098007972

0.81690552

2.382205906

-0.493379806

0.997690695

-0.481056749

0.805740236

neg_ctrl

Virus_target

Joint_1

hvTR_Q2HR71

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Joint_X_strong

ACTTGATGGTTT _A_Concatenation AGTTAGGCTCTT _B

Target(s)

Target(s)

-0.322296954

0.06488456

3.557915354

-1.277257877

0.983636094

-0.491245385

0.855822345

Virus_target

Human target

hvTR_Q2HR73

TOX4

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

mid_X_mid

Joint_ 2_A/u splice_ ATGACCCCTTGT _b

neg_ctrl

Target(s)

1.730229933

0.0030808

-3.967531682

0.13991271

-4.345904336

-0.501470332

neg_ctrl

Human target

Joint_2

LEUTX

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Joint_X_strong

CGCCGGCATACA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.08342302

0.94819089

0.793507026

0.66003866

-1.118935679

-0.523927823

Virus_target

Human target

cds_NC_030656.1_cds_YP_009268729.1_14

LEUTX

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ACTTGATGGTTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.689560504

1.76E-14

3.691474516

0.00947379

1.385903403

0.934700311

-0.52795616

0.78871534

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q2HR73

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATGACCCCTTGT _A_Concatenation AATGGCACTAGC _B

Target(s)

Target(s)

-0.088918236

0.97418471

0.215391642

5.221163403

-0.554234082

Human target

Virus_target

LEUTX

cds_NC_024711.1_cds_YP_009052522.2_44

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

Strong_x_weak

CTACGTGGCCCC _A_Concatenation AATGGCACTAGC _B

Target(s)

Target(s)

1.070267369

0.3372476

3.038721408

0.07417127

-5.616861225

-0.566896372

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_024711.1_cds_YP_009052522.2_44

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

Strong_x_weak

CTACGTGGCCCC _A_Concatenation TTCTAATTTCCT _B

Target(s)

Target(s)

-1.208628829

0.62724977

0.86836222

-1.932944605

-0.568297856

Virus_target

Human target

hvTR_Q2HR71

WDR76

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

Strong_X_strong

CCCGTAGGGGCT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

2.737695209

0.00214501

-4.511290649

0.08521419

3.002873982

-0.572720507

Human target

Human target

TET3

LEUTX

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CATTAGTCCCGC _B

Target(s)

Target(s)

1.072168252

0.01046123

-2.533877112

0.18368446

-3.851308885

-0.577423979

Human target

Virus_target

LEUTX

hvTR_P06930

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

Strong_X_strong

TACATGAGGCAC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.402852754

0.51381092

7.307747202

-0.138343082

0.998501722

-0.609543754

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

hvTR_Q2HR71

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CATCTGAGTCGT _A_Concatenation AGAGTGCGCTCT _B

pos_ctrl_A

neg_ctrl

-0.538858599

0.00021163

2.314796768

0.05613091

1.925242388

0.786741685

-0.615744855

0.78871534

vIRF2_VP64_pos_ctrl

neg_ctrl

RWY_VP16_vIRF2

Random_1

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VIRF2_VP64_pos ctrl_x_random

Joint_ 3_A/u splice_ GAGATTGTGTCC _b

neg_ctrl

Target(s)

0.914604159

0.22734303

4.815385865

0.02204107

-1.576672657

-0.626241051

neg_ctrl

Virus_target

Joint_3

hvTR_Q2HR71

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Joint_X_strong

ATGACCCCTTGT _A_Concatenation AATCAACGAGCA _B

Target(s)

Target(s)

-5.669448975

4.097397656

0.01063608

-1.385614368

-0.65097305

Human target

Human target

LEUTX

C2orf81

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

Strong_X_strong

Joint_ 3_A/u splice_ ATAACTCCACGC _b

neg_ctrl

pos_ctrl_A

-0.39349819

0.31287443

-3.508590097

0.03215821

-0.765871365

0.997690695

-0.657046877

0.766038698

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_3

core_VP64_a

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Linker_X_vIRF2\u VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation AAAACAAGCATT _B

pos_ctrl_A

Target(s)

1.804487019

0.39131086

-1.73865155

-2.733800907

-0.675452747

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_030656.1_cds_YP_009268803.1_88

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

VIRF2_VP64_pos ctrl_x_weak

ATAACTCCACGC _A_Concatenation CCCCTTAGGAAT _B

pos_ctrl_A

Target(s)

0.839023641

0.8027561

2.414347173

0.23997073

-4.516383077

-0.757921072

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

SYNE1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

vIRF2_VP64_pos_ctrl_X_mid

GGAGGCACATCG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.059934018

0.91324404

4.364228877

0.04515966

1.266872898

0.976975145

-0.765924102

0.732968602

Virus_target

Virus_target

hvTR_Q87042

hvTR_Q2HR71

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TACATGAGGCAC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

2.672962453

0.25403675

-0.937537655

0.68844106

-2.340182969

-0.797955314

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

Random_1

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TAAAATTTATCA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.269060835

0.43839885

1.225308514

0.44919764

-0.508753594

0.997690695

-0.808403392

0.725625971

Human target

Virus_target

HSF1

hvTR_Q2HR71

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTACGTGGCCCC _A_Concatenation CTCGCACCGAGG _B

Target(s)

Target(s)

0.550957365

0.01910255

1.319338256

0.51411622

-1.516019058

0.944312715

-0.817640401

0.732968602

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

Strong_X_mid

AGCCAGGTCACC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

2.540194857

0.33149001

4.962885921

0.01226596

-1.9435047

-0.824936823

Human target

Virus_target

MESP1

hvTR_Q2HR71

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATAACTCCACGC _A_Concatenation TGCCAGACGGTC _B

pos_ctrl_A

Target(s)

-2.04917354

0.04492916

-4.213686875

0.01328684

-2.972487272

-0.826380727

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P10541

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation Joint_ 2_B

Target(s)

neg_ctrl

-0.211928221

0.65898029

-5.867676393

1.27E-05

-0.775452408

0.997690695

-0.83154227

0.688672326

Virus_target

neg_ctrl

hvTR_Q2HR73

Joint_2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

Mid_X_joint

AGTTAGGCTCTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.723996645

0.5677544

4.116801314

3.312842368

-0.846634177

Human target

neg_ctrl

TOX4

Random_1

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGATTGTGTCC _A_Concatenation CGATGGCGGAAT _B

Target(s)

Target(s)

1.146138953

0.07185248

3.207461799

0.37526174

-2.996809762

-0.85952028

Virus_target

Human target

hvTR_Q2HR71

KIAA1586

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

Strong_x_weak

GGCCTTTCGGGC _A_Concatenation ATGACCCCTTGT _B

neg_ctrl

Target(s)

-0.400541896

0.04573484

4.381584373

0.06270338

0.564111354

0.997690695

-0.875074478

0.592109514

neg_ctrl

Human target

Random_3

LEUTX

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Random_x_strong

ACTTGATGGTTT _A_Concatenation EPICXV.47_B

Target(s)

pos_ctrl_A

0.494321833

0.17175141

-4.44439168

0.00263683

-0.612752693

0.997690695

-0.878427045

0.788744967

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR73

3x_vIRF2_core

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GCAGATTCGAAT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

2.120648797

8.34E-10

-3.902420942

0.12217257

-1.466572137

-0.885948177

Human target

Virus_target

AK9

hvTR_Q2HR71

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTACGTGGCCCC _A_Concatenation GCAGATTCGAAT _B

Target(s)

Target(s)

0.811892488

0.62420761

-3.7416591

0.04116014

-1.846880318

-0.909683882

Virus_target

Human target

hvTR_Q2HR71

AK9

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

Strong_X_mid

CTACGTGGCCCC _A_Concatenation TGGCCCCCAGTT _B

Target(s)

Target(s)

-0.494669917

0.9128227

-6.429569599

0.05144176

-2.913507046

-0.916480965

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q3I8P6

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

Strong_x_weak

ATGACCCCTTGT _A_Concatenation CGCCGGCATACA _B

Target(s)

Target(s)

-3.687054174

0.01760626

-3.60411821

-4.979090518

-0.947124322

Human target

Virus_target

LEUTX

cds_NC_030656.1_cds_YP_009268729.1_14

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

Strong_X_strong

AAGACCGGTGCC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.085516966

0.94114356

2.783741197

0.13013389

-2.2657589

-0.993498609

Virus_target

Virus_target

hvTR_P08392

hvTR_Q2HR71

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTACGTGGCCCC _A_Concatenation ATTGTATCTAAC _B

Target(s)

Target(s)

0.590080729

4.02E-05

1.990784051

0.07667512

-0.443107974

0.997690695

-1.004313695

0.719038091

Virus_target

Human target

hvTR_Q2HR71

SMARCB1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

Strong_X_mid

AATCAACGAGCA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.980585546

0.61505192

3.899811011

0.00628323

2.064058395

-1.006704138

Human target

Human target

C2orf81

LEUTX

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ACTTGATGGTTT _A_Concatenation TCTGTACCAACG _B

Target(s)

Target(s)

-0.11382315

0.8649368

2.678961277

0.08025707

-0.607800977

0.997690695

-1.010498117

0.757792132

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q6XA69

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

Mid_X_unknown

GAGATTGTGTCC _A_Concatenation TGCCAGACGGTC _B

Target(s)

Target(s)

0.826626805

0.01801161

-5.188256674

8.78E-05

-2.492841999

-1.031494173

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P10541

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

Strong_X_strong

ACTTGATGGTTT _A_Concatenation GTACATACCGAA _B

Target(s)

Target(s)

2.774341471

0.11494945

3.918909602

0.04835416

3.140844427

-1.040385367

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

mid_X_mid

Stop-1_A/u splice_ AGAGTGCGCTCT _b

neg_ctrl

neg_ctrl

-0.378530815

0.9237149

-6.461330284

0.00909169

-4.991686999

-1.040751749

neg_ctrl

neg_ctrl

Stop_1

Random_1

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Termination_X_random

AGAGTGCGCTCT _A_Concatenation TTTAACGGATTG _B

neg_ctrl

Target(s)

-0.553050077

0.06230516

4.271412911

0.07496967

-0.342746968

0.997690695

-1.056103356

0.74332815

neg_ctrl

Human target

Random_1

TWIST2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

Random_x_mid

AGCCAGGTCACC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.262070012

0.00738617

5.693277462

0.00384211

-1.231121382

0.987041604

-1.068983275

0.651954269

Human target

Virus_target

MESP1

hvTR_Q2HR73

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATAACTCCACGC _A_Concatenation AATCAACGAGCA _B

pos_ctrl_A

Target(s)

-1.183345249

0.3372476

-3.206646883

0.12067699

-4.733725612

-1.073277813

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

C2orf81

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

VIRF2_VP64_pos strong_ctrl_x_strong

ATGACCCCTTGT _A_Concatenation TATTAAAAGTGC _B

Target(s)

Target(s)

-1.698386659

0.24013675

1.752334443

0.46758098

-0.707224663

-1.077559948

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_202

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

Strong_x_weak

AAGGGTAAATTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.642548493

0.45084025

1.649250306

0.59759538

-3.061227687

-1.098696638

Virus_target

Human target

hvTR_Q69513

LEUTX

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GTCACCCTCCTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.481471862

0.47572323

-5.43138779

0.05047949

-3.061227687

-1.098696638

Human target

Virus_target

E2F5

hvTR_Q2HR73

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TGGCCCCCAGTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.830732458

0.5512515

-3.262305118

0.07113173

-0.082093905

-1.110130765

Virus_target

Virus_target

hvTR_Q3I8P6

hvTR_Q2HR71

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

TTTAACGGATTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.232194054

0.00599572

-4.702210671

0.00133574

-1.51716174

-1.122529507

Human target

neg_ctrl

TWIST2

Random_1

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AGAGTGCGCTCT _A_Concatenation Joint_ 1_B

neg_ctrl

neg_ctrl

-0.690665027

0.5040267

-4.242238155

0.01469877

-3.62880795

-1.133291251

neg_ctrl

neg_ctrl

Random_1

Joint_1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

Random_X_joint

GAGATTGTGTCC _A_Concatenation TCAGCCGTAGGC _B

Target(s)

Target(s)

1.400000224

0.00086312

9.194258414

5.99E-06

-0.737175654

0.997690695

-1.134471708

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q805Y1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

Strong_X_mid

TTAGTGCCATAC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.414165855

0.93141616

5.143894465

0.07669979

-3.29232035

-1.137645961

Human target

Virus_target

TET3

hvTR_Q2HR71

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GACTGTGGGCGG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.23397005

0.91324404

-5.357411474

0.02354207

3.531501053

-1.146163925

Human target

neg_ctrl

MON2

Random_1

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

GAGATTGTGTCC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.402463196

0.82490703

-1.142345969

0.4983473

0.685612219

-1.148541528

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

GATGGAGCTACA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.720771518

0.38424667

-6.654018347

0.00092549

-1.170940493

-1.155680211

Virus_target

neg_ctrl

hvTR_P03209

Random_1

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

Joint_ 3_A/u splice_ ACTTGATGGTTT _b

neg_ctrl

Target(s)

-0.312437299

0.82544101

1.293745977

0.50792395

-4.798331251

-1.164748571

neg_ctrl

Virus_target

Joint_3

hvTR_Q2HR73

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Joint_X_mid

ATGACCCCTTGT _A_Concatenation AATCGAGACCAG _B

Target(s)

Target(s)

-1.876497825

0.23717823

1.885843983

0.42878603

-3.1287446

-1.170254333

Human target

Virus_target

LEUTX

hvTR_Q8BB47

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

Strong_X_strong

ATTGTATCTAAC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.676361145

0.16619678

2.070979426

0.06790309

-0.576424272

-1.178957286

Human target

Virus_target

SMARCB1

hvTR_Q2HR71

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATGACCCCTTGT _A_Concatenation CCCTGCCTCGGG _B

Target(s)

Target(s)

-4.915335629

0.00309758

0.335590485

0.88038733

-1.938327017

-1.186645099

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

Strong_X_mid

GGAGGCACATCG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.664609429

0.00443535

5.309696582

0.00156378

-1.784748802

0.953105946

-1.203388423

0.709382773

Virus_target

Human target

hvTR_Q87042

LEUTX

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

CAACGCATGCCT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.194983769

0.93141616

5.70838569

-3.171964635

-1.216060719

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

Random_1

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

GAGATTGTGTCC _A_Concatenation TGGCCCCCAGTT _B

Target(s)

Target(s)

-0.633434576

0.92885234

-6.079958704

0.11085332

1.349299666

-1.218768567

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q3I8P6

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

Strong_x_weak

TAAGATTCAACG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.618316917

0.37291537

-2.712224398

0.08545263

0.024823774

-1.224777916

Human target

Virus_target

ZNF292

hvTR_Q2HR71

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CTCGTTATGGCA _B

Target(s)

Target(s)

-0.337309731

0.56627226

5.580687498

-0.574579268

0.997690695

-1.243522131

0.590310725

Human target

Human target

LEUTX

NOVA1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

Strong_X_mid

AGCCAGGTCACC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.469802137

0.6257227

-4.588019927

0.00562514

-4.505666369

-1.249186776

Human target

Virus_target

MESP1

hvTR_Q2HR71

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CTACGTGGCCCC _A_Concatenation TACATGAGGCAC _B

Target(s)

Target(s)

0.951393057

0.07182709

-2.193355556

0.20612557

-2.912012875

0.624937505

-1.254992502

0.700713833

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation AAGACCGGTGCC _B

neg_ctrl

Target(s)

0.263197881

0.48649146

4.362150732

0.04317516

-0.41567701

0.997690695

-1.260092603

0.585780662

neg_ctrl

Virus_target

Random_1

hvTR_P08392

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

Random_x_mid

ATCCAATCTGTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.207701323

0.93606303

-7.302124202

0.02483009

6.737934355

-1.292106645

Human target

Virus_target

GLI2

hvTR_Q2HR71

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GAGATTGTGTCC _A_Concatenation GGCACAGCTCCA _B

Target(s)

Target(s)

-1.019394625

6.90E-06

-5.337569441

0.00051097

-1.344303758

0.976975145

-1.30506071

0.590310725

Virus_target

Human target

hvTR_Q2HR71

DTX2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

Strong_x_unknown

ACTTGATGGTTT _A_Concatenation TAAAATTTATCA _B

Target(s)

Target(s)

-0.236987671

0.72546447

-2.808554146

0.03117913

0.462950466

0.997690695

-1.305537631

0.683950209

Virus_target

Human target

hvTR_Q2HR73

HSF1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

mid_X_mid

AGCCAGGTCACC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.071350579

4.95E-17

-0.519895018

-0.560485241

0.997690695

-1.31982972

0.581500394

Human target

vIRF2_VP64_pos_ctrl

MESP1

core_VP64_a

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation ACTTTAGTAACA _B

Target(s)

Target(s)

-0.59868988

0.16937431

1.968833576

0.23689969

-0.098878819

-1.325485885

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q69113

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation ATGACCCCTTGT _B

neg_ctrl

Target(s)

-0.051339931

0.95452661

-0.842480429

0.57034604

0.040324128

-1.345280033

neg_ctrl

Human target

Random_1

LEUTX

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Random_x_strong

ATAACTCCACGC _A_Concatenation AATGGCACTAGC _B

pos_ctrl_A

Target(s)

0.003300817

0.99110789

1.956345028

0.36653395

-0.188317863

0.998501722

-1.358020785

0.548443218

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_024711.1_cds_YP_009052522.2_44

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

VIRF2_VP64_pos ctrl_x_weak

ATGACCCCTTGT _A_Concatenation TAAGATTCAACG _B

Target(s)

Target(s)

2.993728693

0.12001523

1.721485604

0.2646259

0.861736055

-1.359126778

Human target

Human target

LEUTX

ZNF292

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

Strong_X_strong

CATTAGTCCCGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.404938826

1.616105388

0.22849993

3.419125043

-1.370894521

Virus_target

Human target

hvTR_P06930

LEUTX

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

CTCCATTAATGA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.501919533

0.61505192

3.854044641

0.15241597

0.655071563

0.997690695

-1.379828556

0.641868474

Virus_target

Virus_target

hvTR_Q5IXR3

hvTR_Q2HR73

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

ACTTTAGTAACA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.485823829

0.7246252

3.424520929

0.02230835

-1.524999847

-1.380908539

Virus_target

Virus_target

hvTR_Q69113

hvTR_Q2HR71

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TTCTAATTTCCT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.320473009

0.45084025

-2.955972296

0.23767729

-1.759217618

-1.392957897

Human target

Virus_target

WDR76

hvTR_Q2HR71

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ACTTGATGGTTT _A_Concatenation CCCTATGTTCTA _B

Target(s)

pos_ctrl_A

-0.57413273

0.12232448

-1.938414189

0.3017597

-1.039330028

0.997690695

-1.403891342

0.535512412

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR73

core_VP64_b

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CATGCTAACACC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.914882633

0.64865022

1.432179596

0.52840079

-3.156853676

-1.404876493

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_F5HCV3

core_VP64_a

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation ACTCGTGTTGTC _B

Target(s)

Target(s)

0.156561328

0.68024065

-2.044018389

0.29772089

-0.862335606

0.997690695

-1.405500297

0.575478509

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q9QB97

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

Strong_X_mid

ATGACCCCTTGT _A_Concatenation ACGACTCACCGC _B

Target(s)

Target(s)

-3.130422085

0.17986762

-3.346803733

-1.405895358

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CGGCAATTGCTT _B

Target(s)

Target(s)

0.458480564

0.39898368

7.739036206

0.01385828

-2.576052844

-1.425199802

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q9QB93

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

Strong_X_mid

ATGACCCCTTGT _A_Concatenation Stop_1_B

Target(s)

neg_ctrl

-0.71048149

0.18077802

5.762022346

0.00052905

-0.315943885

0.997690695

-1.433616011

0.485515241

Human target

neg_ctrl

LEUTX

Stop_1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

Strong_X_termination

GAGATTGTGTCC _A_Concatenation AAGACCGGTGCC _B

Target(s)

Target(s)

-1.502566843

0.09668495

8.608880569

-0.057058423

-1.447491287

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P08392

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

Strong_X_mid

ATAACTCCACGC _A_Concatenation GCAGATTCGAAT _B

pos_ctrl_A

Target(s)

0.46078564

0.89748071

-1.393432938

0.62046092

-5.28859147

-1.458440777

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

AK9

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

vIRF2_VP64_pos_ctrl_X_mid

ATAACTCCACGC _A_Concatenation AGTTAGGCTCTT _B

pos_ctrl_A

Target(s)

0.209226693

0.81658896

-3.869650017

0.0038591

-2.047607054

-1.468468127

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TOX4

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

vIRF2_VP64_pos_ctrl_X_mid

GGCACAGCTCCA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.423468769

0.84967001

-5.796035749

0.01582874

-1.081408981

-1.468587795

Human target

Virus_target

DTX2

hvTR_Q2HR71

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

GGCCTTTCGGGC _A_Concatenation CTACGTGGCCCC _B

neg_ctrl

Target(s)

0.588772206

0.72546447

-2.145075882

0.29075112

-2.843661949

-1.472764939

neg_ctrl

Virus_target

Random_3

hvTR_Q2HR71

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Random_x_strong

ATAACTCCACGC _A_Concatenation TATCGCAAGAAC _B

pos_ctrl_A

neg_ctrl

-0.222624222

0.90519313

-5.853449744

0.13957468

-0.593060379

-1.48123928

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Random_5

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

VIRF2_VP64_pos ctrl_x_random

CTACGTGGCCCC _A_Concatenation ACTCGTGTTGTC _B

Target(s)

Target(s)

-0.424776086

0.5677544

0.068952382

0.96542848

-5.799855803

-1.504025224

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q9QB97

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

Strong_X_mid

GAGACAGCTCTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.783689814

0.6161502

-1.323523101

0.61908967

-1.902982934

-1.511914004

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

LEUTX

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CTCACGACAAGA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.754996002

0.18334753

-1.252801728

0.43792599

-0.77340744

-1.526512169

Virus_target

Virus_target

hvTR_G3G929

hvTR_Q2HR73

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

AATGGCACTAGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.462215585

0.00037251

6.14117484

-0.423953789

0.997690695

-1.534893921

0.4051583

Virus_target

Virus_target

cds_NC_024711.1_cds_YP_009052522.2_44

hvTR_Q2HR73

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

TATTAAAAGTGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

2.122770816

0.02838239

-5.2194232

0.17840605

-3.467551469

-1.538004976

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_202

Random_1

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

AGCCGTGCTTGA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.748251812

0.0007241

5.002751278

0.0029459

-0.714227476

0.997690695

-1.543872779

0.446668493

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

core_VP64_a

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation GAGACAGCTCTC _B

neg_ctrl

Target(s)

0.126940751

0.92929931

-4.749550792

-6.860744528

-1.564192362

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

Random_x_mid

ATAACTCCACGC _A_Concatenation ACAACGTGCATA _B

pos_ctrl_A

Target(s)

0.882671467

0.25462682

2.657280244

3.254550073

-1.565592784

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P10407

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

VIRF2_VP64_pos strong_ctrl_x_strong

GAGATTGTGTCC _A_Concatenation TCTTAGAGGGTG _B

Target(s)

Target(s)

0.39830039

0.27923268

1.601564011

0.692935403

-1.570919949

Virus_target

Human target

hvTR_Q2HR71

TRO

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

Strong_X_strong

CATTGTTTAAAT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.368056682

0.61264864

7.236679287

0.00064757

-1.718382566

-1.582944188

Human target

Virus_target

POLR1E

hvTR_Q2HR71

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Unknown_X_strong

EPICXV.47-A\u splice_ AGAGTGCGCTCT _b

pos_ctrl_A

neg_ctrl

-0.388802177

0.72633824

-6.391157771

3.10E-05

0.778466665

0.997690695

-1.587143842

0.472641252

vIRF2_VP64_pos_ctrl

neg_ctrl

3x_vIRF2_core

Random_1

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VIRF2_VP64_pos ctrl_x_random

GGCACTGTCGAG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.36305039

0.23304751

5.324118927

0.02116379

-0.586088657

0.997690695

-1.612838325

0.518376375

Virus_target

Virus_target

hvTR_P17147

hvTR_Q2HR73

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

CTACGTGGCCCC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.726792141

2.29E-06

3.043343726

0.14649582

-0.443282723

0.997690695

-1.616257529

0.280957837

Virus_target

Human target

hvTR_Q2HR71

LEUTX

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

GAGATTGTGTCC _A_Concatenation AGCCGTGCTTGA _B

Target(s)

Target(s)

-0.50711417

0.28757726

-4.558879821

0.01096213

0.115953096

0.998501722

-1.617280117

0.585780662

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

Strong_x_weak

CTACGTGGCCCC _A_Concatenation AAACTTTGAGCG _B

Target(s)

Target(s)

1.271730072

0.7442977

13.65581628

0.00015285

3.925342192

-1.621858471

Virus_target

Human target

hvTR_Q2HR71

ATF6B

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CTCGCACCGAGG _B

Target(s)

Target(s)

-0.67028454

0.07718954

0.900820929

-1.304407356

0.997690695

-1.636234168

0.590310725

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

Strong_X_mid

TCAGCCGTAGGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.42417603

0.8649368

-4.902742015

0.03818366

-4.602118995

-1.640648452

Virus_target

Virus_target

hvTR_Q805Y1

hvTR_Q2HR73

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

AAGCAACGATAT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

2.894668905

0.00345227

4.516546955

-3.562946978

-1.64234607

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

hvTR_Q2HR73

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CTGCCGGTTGCG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.063907298

2.04E-05

6.032562203

0.00143454

-0.604239271

0.997690695

-1.642801946

0.243715546

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

core_VP64_a

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

GGAGGCACATCG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.572873755

0.04092758

-3.479695208

0.00451841

-0.157714734

0.998501722

-1.650850724

0.445938924

Virus_target

Virus_target

hvTR_Q87042

hvTR_Q2HR73

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTACGTGGCCCC _A_Concatenation ACTTTAGTAACA _B

Target(s)

Target(s)

0.733134025

0.24325835

4.158005905

0.0451167

0.615771666

-1.651783857

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q69113

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

Strong_X_strong

CCGCCCTTATGT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.790226474

0.01206131

-4.464166686

0.0178468

-0.566136385

0.997690695

-1.660573902

0.570993876

Human target

Virus_target

ZFX

hvTR_Q2HR71

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CACACCCGGCAG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.195109347

0.86342423

1.493292461

0.48138613

0.11866136

0.998501722

-1.670331246

0.433279853

Virus_target

Human target

hvTR_P19893

LEUTX

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

TACTTCTAGCGG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.784841274

0.63450624

-1.064653633

0.57110568

-3.117120781

-1.673882311

Virus_target

Human target

cds_NC_025350.1_cds_YP_009094080.1_7

LEUTX

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation ATGACAAAACGA _B

Target(s)

Target(s)

0.913056242

0.01809398

0.526036262

0.77751675

0.499158773

0.997690695

-1.687160384

0.585780662

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_025350.1_cds_YP_009094074.1_1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

Mid_X_strong

ATAACTCCACGC _A_Concatenation GAGTGACCTATT _B

pos_ctrl_A

Target(s)

0.110313531

0.78371714

-4.560661081

0.00277922

-0.449309135

0.997690695

-1.687879513

0.415099063

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

VIRF2_VP64_pos ctrl_x_unknown

TTTAACGGATTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.169013307

0.00229408

7.330801724

1.10544762

-1.688418597

Human target

vIRF2_VP64_pos_ctrl

TWIST2

core_VP64_a

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation CCAGACGGTCTG _B

Target(s)

Target(s)

0.328468287

0.6679075

-1.436414283

0.20783496

1.225878654

0.983636094

-1.707489963

0.361838437

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

Strong_x_weak

ACTTGATGGTTT _A_Concatenation CATGCTAACACC _B

Target(s)

Target(s)

1.710593625

3.78E-75

4.657317809

1.13E-06

0.039457423

0.998501722

-1.729358705

0.405632218

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_F5HCV3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

Mid_X_strong

Joint_ 2_A/u splice_ ACTTGATGGTTT _b

neg_ctrl

Target(s)

-0.461872651

0.80545181

-5.383685315

0.15616264

0.40853789

-1.730223487

neg_ctrl

Virus_target

Joint_2

hvTR_Q2HR73

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Joint_X_mid

ACGACTCACCGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.47526773

0.53101873

-3.49903507

0.24883971

-3.458910944

-1.738847318

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

LEUTX

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CCCCTTAGGAAT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

4.659860773

0.0188851

-3.173081868

0.36653395

-3.651954814

-1.739646685

Human target

Virus_target

SYNE1

hvTR_Q2HR71

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

GAGATTGTGTCC _A_Concatenation TACTTCTAGCGG _B

Target(s)

Target(s)

0.051776607

0.9854934

1.039707877

0.6950775

-5.511509453

-1.758609214

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094080.1_7

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

Strong_x_weak

ATAACTCCACGC _A_Concatenation ACTTTAGTAACA _B

pos_ctrl_A

Target(s)

0.166828144

0.82429662

-0.400599966

0.85606566

1.0459779

0.997690695

-1.76431366

0.557484003

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q69113

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

VIRF2_VP64_pos strong_ctrl_x_strong

AGAGTGCGCTCT _A_Concatenation TATCGCAAGAAC _B

neg_ctrl

neg_ctrl

0.077618259

0.93141616

5.211493031

0.07650549

-6.43656676

-1.77418533

neg_ctrl

neg_ctrl

Random_1

Random_5

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

Random_x_random

GCGAGGCAGACC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.118132135

0.29193745

-4.7347035

0.14027063

-3.096955612

-1.804408019

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

hvTR_Q2HR73

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

TATCGCAAGAAC _A_Concatenation ATAACTCCACGC _B

neg_ctrl

pos_ctrl_A

-0.893661978

0.01058498

2.820458751

0.06099515

0.805997478

0.997690695

-1.810729438

0.280364708

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_5

core_VP64_a

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Random_X_vIRF2\u VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation Stop_2_B

Target(s)

neg_ctrl

-0.175960152

0.9238208

5.537449911

0.16379541

-3.721847523

-1.81600017

Human target

neg_ctrl

LEUTX

Stop_2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

Strong_X_termination

ACTTGATGGTTT _A_Concatenation GATCGCATGTTC _B

Target(s)

Target(s)

0.574415704

0.09356214

-6.589762935

1.01E-07

-0.343454987

0.997690695

-1.834572976

0.37951222

Virus_target

Human target

hvTR_Q2HR73

INPP4A

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

Mid_X_strong

CTACGTGGCCCC _A_Concatenation AGCCGTGCTTGA _B

Target(s)

Target(s)

0.77193196

0.78044287

-3.356763777

0.12707002

-1.059465518

-1.84197453

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

Strong_x_weak

EPICXV.47-A\u splice_ ATGACCCCTTGT _b

pos_ctrl_A

Target(s)

-2.931314649

0.43839885

-2.301199062

0.28348131

-1.093673031

-1.870898068

vIRF2_VP64_pos_ctrl

Human target

3x_vIRF2_core

LEUTX

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VIRF2_VP64_pos strong_ctrl_x_strong

GACTGTGGGCGG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.835179305

0.86010689

-3.385362422

-3.580736385

-1.873576209

Human target

vIRF2_VP64_pos_ctrl

MON2

core_VP64_a

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation AATCGAGACCAG _B

Target(s)

Target(s)

-2.308340043

0.37525592

-0.076247704

-3.775248939

-1.874300662

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q8BB47

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AAAACAAGCATT _B

Target(s)

Target(s)

-1.102525805

0.66445658

-5.643740376

0.04032533

-0.797450345

-1.875352064

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_030656.1_cds_YP_009268803.1_88

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

Strong_x_weak

GGAGGCACATCG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.144870239

0.0476953

4.542389949

0.03932477

-0.703453694

0.997690695

-1.921568235

0.447639814

Virus_target

neg_ctrl

hvTR_Q87042

Random_1

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation CACACCCGGCAG _B

pos_ctrl_A

Target(s)

1.042063125

3.86E-06

6.880474115

5.64E-11

-0.376437208

0.997690695

-1.924257012

0.280453332

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P19893

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation GGCACAGCTCCA _B

Target(s)

Target(s)

0.104819291

0.86342423

-1.496750801

0.3793835

-0.191747038

0.998501722

-1.942893444

0.509470315

Virus_target

Human target

hvTR_Q2HR73

DTX2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

Mid_X_unknown

GAGATTGTGTCC _A_Concatenation AGTTGCTTTGCT _B

Target(s)

neg_ctrl

1.204079194

0.35721727

-5.634491704

0.02709971

-2.440687278

-1.952353931

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

Strong_X_random

ATGACAAAACGA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.351001561

0.71346073

-3.61100703

0.07226686

0.92028625

0.997690695

-1.956465917

0.360767917

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094074.1_1

hvTR_Q2HR71

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATAACTCCACGC _A_Concatenation Joint_ 1_B

pos_ctrl_A

neg_ctrl

-0.261725403

0.76101183

-3.972751417

0.00156378

-0.119908033

0.998501722

-1.974284598

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Joint_1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

VIRF2_VP64_pos ctrl X joint

AGAGTGCGCTCT _A_Concatenation CGGCAATTGCTT _B

neg_ctrl

Target(s)

-1.507279606

0.27923268

-6.668416317

0.02011974

-4.09003386

-1.976355916

neg_ctrl

Virus_target

Random_1

hvTR_Q9QB93

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

Random_x_mid

CAGTGACATAGT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.406085157

0.37291537

3.528871636

0.01939364

3.963397906

-1.97969583

Human target

Human target

EHMT2

LEUTX

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AATCAACGAGCA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.317086427

0.81690552

-3.834792733

0.02550846

-0.292858768

-1.982265083

Human target

vIRF2_VP64_pos_ctrl

C2orf81

core_VP64_a

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation ACCAGTATTTAA _B

Target(s)

Target(s)

0.870290428

0.04649857

6.057755475

0.00040535

0.916883495

0.997690695

-1.989612997

0.213367908

Virus_target

Human target

hvTR_Q2HR73

ARNTL2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Mid_X_strong

GTCACCCTCCTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

2.501462385

0.49700987

1.687073928

0.53133427

4.260069206

-1.991590924

Human target

Human target

E2F5

LEUTX

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation ACGACTCACCGC _B

neg_ctrl

Target(s)

-0.874822372

0.27923268

-4.226350992

0.11075086

-2.71536985

-1.993643846

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

Random_x_mid

CATCTCACCTAG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.650312974

0.00010198

6.428866094

0.00108214

-1.163978859

-2.014637743

Virus_target

Virus_target

hvTR_P03206

hvTR_Q2HR71

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTGGTAGTTGTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.182432988

0.09988704

2.407166562

0.33543664

-5.138530846

-2.030076169

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_F6KS47

core_VP64_a

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

GCAACGAGGGTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.715265396

0.36968355

-0.815252808

-4.908479493

-2.033995172

Human target

neg_ctrl

QRICH2

Random_1

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TCTGTACCAACG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.011782545

0.27923268

-5.827280848

0.00104225

0.480938784

-2.038462525

Virus_target

Human target

hvTR_Q6XA69

LEUTX

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

GAGATTGTGTCC _A_Concatenation AATCAACGAGCA _B

Target(s)

Target(s)

-0.937772811

6.28E-10

0.923364823

-1.264547408

0.976975145

-2.044713834

0.218195585

Virus_target

Human target

hvTR_Q2HR71

C2orf81

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

Strong_X_strong

GATGGAGCTACA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.824540175

0.23357818

-1.913333917

0.29772089

-0.376599198

-2.045450749

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR73

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation AGGCTTCCCGCT _B

neg_ctrl

Target(s)

0.786791801

0.7246252

-5.900124845

0.13219999

-4.931782681

-2.054669552

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

Random_x_mid

ATAACTCCACGC _A_Concatenation AAACTTTGAGCG _B

pos_ctrl_A

Target(s)

0.116399123

0.97914877

5.523543725

0.13526627

4.337398052

-2.076833276

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ATF6B

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation Stop_1_B

Target(s)

neg_ctrl

1.328434196

3.67E-15

5.450879913

0.00057184

-1.241199176

0.976975145

-2.07848395

0.166242467

Virus_target

neg_ctrl

hvTR_Q2HR73

Stop_1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

Mid_X_termination

CATGCTAACACC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.444373572

0.80691093

7.687319261

0.00026118

-3.795047491

-2.110304387

Virus_target

Virus_target

hvTR_F5HCV3

hvTR_Q2HR71

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TGATGAGCGCCC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.366385995

0.01662228

-0.409429918

0.74529559

-0.619370617

0.997690695

-2.110912066

0.260152305

Human target

Virus_target

EEF1D

hvTR_Q2HR73

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

ATGACAAAACGA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.146081921

0.93202829

2.191024386

0.19018098

2.554561485

-2.117730862

Virus_target

neg_ctrl

cds_NC_025350.1_cds_YP_009094074.1_1

Random_1

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation GCGAGGCAGACC _B

pos_ctrl_A

Target(s)

-0.781894849

0.09842699

-6.455380163

3.89E-06

-3.024620924

-2.11829931

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

VIRF2_VP64_pos ctrl_x_unknown

CTACGTGGCCCC _A_Concatenation TTTAACGGATTG _B

Target(s)

Target(s)

0.286615487

0.32367186

6.31278232

0.00033095

0.176741699

0.998501722

-2.119345883

0.214928132

Virus_target

Human target

hvTR_Q2HR71

TWIST2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

Strong_X_mid

TCTTAGAGGGTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.536087357

0.27973193

-6.136270964

0.00036095

-3.307702299

-2.12122524

Human target

neg_ctrl

TRO

Random_1

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AAACTTTGAGCG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.08222404

0.91324404

0.344188269

0.89007548

0.966278311

0.997690695

-2.125851811

0.205419389

Human target

Virus_target

ATF6B

hvTR_Q2HR71

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

CTACGTGGCCCC _A_Concatenation AATCGAGACCAG _B

Target(s)

Target(s)

-0.276567538

0.8410287

0.796178088

0.77340766

-1.752742327

-2.129471962

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q8BB47

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

Strong_X_strong

ATGACCCCTTGT _A_Concatenation AGCCGTGCTTGA _B

Target(s)

Target(s)

1.073034753

0.65676761

4.400296147

-2.146092094

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

Strong_x_weak

AGCCATAAACCT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.703893146

0.2062555

10.18787157

0.00011919

-0.256995675

0.998501722

-2.147117461

0.411526549

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR71

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AGCCATAAACCT _B

Target(s)

Target(s)

-0.486899537

0.5449371

-5.564379368

0.00710378

-4.16221969

-2.148279884

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03209

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

Strong_X_mid

ACAACGTGCATA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.387306973

0.00125477

3.709797297

0.0478769

-1.353535051

-2.155272728

Virus_target

neg_ctrl

hvTR_P10407

Random_1

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CATGCTAACACC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.423524178

0.29119771

3.377280653

0.03336571

0.937763798

-2.156749779

Virus_target

Human target

hvTR_F5HCV3

LEUTX

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

TACTTCTAGCGG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-1.652334024

0.61787605

5.512740473

0.00109019

2.922156751

-2.161319299

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094080.1_7

hvTR_Q2HR71

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

ATAACTCCACGC _A_Concatenation TAAGATTCAACG _B

pos_ctrl_A

Target(s)

-0.418214463

0.76970415

-1.702104054

0.49899652

1.3428249

-2.1652639

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ZNF292

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

VIRF2_VP64_pos strong_ctrl_x_strong

TCTTGGTTTTGA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.306373142

0.77086475

-4.778064282

0.02389526

0.65423091

0.997690695

-2.17056458

0.218195585

Human target

Virus_target

ZNF597

hvTR_Q2HR73

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GAGATTGTGTCC _A_Concatenation GGAGGCACATCG _B

Target(s)

Target(s)

-0.62525844

0.75592103

-3.708128685

0.00448128

-5.115835852

-2.170838839

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q87042

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

Strong_X_strong

GCGAGGCAGACC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.621708401

0.03731663

-0.11925813

0.96542848

-1.501399203

-2.172105589

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

hvTR_Q2HR71

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

ATAACTCCACGC _A_Concatenation CCTAAATGCAAG _B

pos_ctrl_A

Target(s)

0.682806739

0.59926862

-5.906280331

0.01927929

-3.037905766

-2.190606412

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_025410.1_cds_YP_009094498.1_7

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

vIRF2_VP64_pos_ctrl_X_mid

CTACGTGGCCCC _A_Concatenation CCGCCCTTATGT _B

Target(s)

Target(s)

3.06726255

0.48198592

8.72095708

1.08E-06

-4.078700875

-2.204782525

Virus_target

Human target

hvTR_Q2HR71

ZFX

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation TAAAATTTATCA _B

neg_ctrl

Target(s)

-0.20300756

0.926639

-0.931926182

0.73748128

-3.393950498

-2.214449527

neg_ctrl

Human target

Random_1

HSF1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

Random_x_mid

AGTTGCTTTGCT _A_Concatenation AGAGTGCGCTCT _B

neg_ctrl

neg_ctrl

-0.087536792

0.94626231

4.1949744

0.410153126

-2.22013316

neg_ctrl

neg_ctrl

Random_2

Random_1

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Random_x_random

GATGGAGCTACA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.887384943

0.29698201

3.296477797

0.08125073

1.702949842

-2.230260513

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR71

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

TTTAACGGATTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.174022666

0.9335834

-4.760184858

0.03096016

-3.91081508

-2.237911962

Human target

Virus_target

TWIST2

hvTR_Q2HR73

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TCTTAGAGGGTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.290610473

0.00442279

-4.665711543

0.00059041

-1.837223793

-2.244081419

Human target

Virus_target

TRO

hvTR_Q2HR71

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CATGCTAACACC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.631396667

0.14446217

2.547201248

0.15596426

-1.765278122

0.953105946

-2.271078994

0.410501623

Virus_target

Virus_target

hvTR_F5HCV3

hvTR_Q2HR73

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATCCAATCTGTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

2.241931715

0.33007877

-3.331293553

0.26509579

0.413339493

-2.273726897

Human target

neg_ctrl

GLI2

Random_1

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AAACTTTGAGCG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.096584118

0.94020164

-5.695800149

0.00855636

-2.527967424

-2.281588967

Human target

Virus_target

ATF6B

hvTR_Q2HR73

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GATCGCATGTTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.845452262

0.38265522

-1.92334639

0.31502412

-0.709287021

-2.303356666

Human target

Virus_target

INPP4A

hvTR_Q2HR73

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATGACCCCTTGT _A_Concatenation GGAGGCACATCG _B

Target(s)

Target(s)

1.83951509

0.21129976

-0.09648376

0.95339043

3.039571002

-2.310562021

Human target

Virus_target

LEUTX

hvTR_Q87042

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

Strong_X_strong

AGCCATAAACCT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.23329157

0.92304294

3.123626982

0.21612015

2.269054435

-2.314081628

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR71

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATCTCTCAGTTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.506326202

0.00031847

6.180269477

0.00071096

1.851584313

0.933317674

-2.314930064

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

core_VP64_a

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation CAGTGACATAGT _B

pos_ctrl_A

Target(s)

0.689968443

0.03846116

-6.522655629

5.25E-07

0.809519735

-2.316066855

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

EHMT2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

vIRF2_VP64_pos_ctrl_X_mid

ATGACCCCTTGT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.984744494

0.197473

4.395721525

0.04017978

0.04216418

-2.324458443

Human target

Virus_target

LEUTX

hvTR_Q2HR73

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CTCGTTATGGCA _B

Target(s)

Target(s)

1.467396299

0.26992692

-6.566344077

0.0001379

-0.280644693

-2.340477918

Virus_target

Human target

hvTR_Q2HR71

NOVA1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

Strong_X_mid

ACTTGATGGTTT _A_Concatenation GACTGTGGGCGG _B

Target(s)

Target(s)

0.345234247

0.93114725

-0.923832766

0.70352371

4.582024468

-2.345754002

Virus_target

Human target

hvTR_Q2HR73

MON2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

Mid_X_strong

ATAACTCCACGC _A_Concatenation CCCTGCCTCGGG _B

pos_ctrl_A

Target(s)

1.3247522

4.75E-07

6.129584023

0.00055535

-0.182736971

0.998501722

-2.347019609

0.203901573

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

vIRF2_VP64_pos_ctrl_X_mid

GAGATTGTGTCC _A_Concatenation TAAAATTTATCA _B

Target(s)

Target(s)

0.380376232

0.01727004

3.792260526

0.06790309

-0.595644588

0.997690695

-2.359856949

0.146899569

Virus_target

Human target

hvTR_Q2HR71

HSF1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

Strong_X_mid

ATAACTCCACGC _A_Concatenation AGTTGCTTTGCT _B

pos_ctrl_A

neg_ctrl

-0.117883532

0.91394475

2.567459099

0.98072853

-2.367654772

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Random_2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

VIRF2_VP64_pos ctrl_x_random

ATGACCCCTTGT _A_Concatenation ACCAGTATTTAA _B

Target(s)

Target(s)

1.26268393

0.85449119

0.73914719

-4.236506875

-2.375972335

Human target

Human target

LEUTX

ARNTL2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation AGCCATAAACCT _B

Target(s)

Target(s)

2.966371354

0.17722959

-3.484670686

0.18368446

-3.768250082

-2.385046463

Human target

Virus_target

LEUTX

hvTR_P03209

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

Strong_X_mid

AATCAACGAGCA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.93220789

0.35187283

-2.349232204

0.04528497

0.075912288

0.998501722

-2.391219803

0.383504477

Human target

Virus_target

C2orf81

hvTR_Q2HR73

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

EPICXV.47-A\u splice_ GAGATTGTGTCC _b

pos_ctrl_A

Target(s)

-1.150809606

0.22884458

0.918991272

0.6645866

-2.515006557

-2.400241664

vIRF2_VP64_pos_ctrl

Virus_target

3x_vIRF2_core

hvTR_Q2HR71

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VIRF2_VP64_pos strong_ctrl_x_strong

TGGCCCCCAGTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.467636579

4.10E-21

-0.238324673

0.89582846

0.355614964

0.997690695

-2.40899104

0.412491923

Virus_target

Virus_target

hvTR_Q3I8P6

hvTR_Q2HR73

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

AAGACCGGTGCC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.033905786

0.95058117

2.677340621

0.18898801

2.04848687

-2.416078356

Virus_target

Virus_target

hvTR_P08392

hvTR_Q2HR73

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CAACGCATGCCT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.507019845

0.63402488

7.341065793

0.04902037

-4.282304325

-2.425555184

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

core_VP64_a

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation ATTTGTAGACCG _B

Target(s)

Target(s)

-0.678633553

0.00020662

1.047632389

0.60710891

-0.998476402

0.997690695

-2.441086679

0.405632218

Human target

Human target

LEUTX

MYCN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

Strong_X_mid

ACTTGATGGTTT _A_Concatenation GGTGTCTCGATT _B

Target(s)

Target(s)

1.146595834

0.42503544

-4.009423488

0.06073326

-4.098673044

-2.444445304

Virus_target

Human target

hvTR_Q2HR73

E2F5

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

Mid_X_strong

TAAGATTCAACG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.651548081

0.73379786

-2.854050345

-0.752642529

-2.458418062

Human target

Virus_target

ZNF292

hvTR_Q2HR71

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

Stop 2_A splice ACTTGATGGTTT B

neg_ctrl

Target(s)

-0.799530923

0.00019667

2.376046442

0.14649582

-0.940138832

0.997690695

-2.467030038

0.205658608

neg_ctrl

Virus_target

Stop_2

hvTR_Q2HR73

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Termination_X_mid

ACTTGATGGTTT _A_Concatenation ACTCGTGTTGTC _B

Target(s)

Target(s)

0.504417835

0.60751198

5.025130913

3.128750176

-2.478619765

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q9QB97

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

mid_X_mid

ATAACTCCACGC _A_Concatenation TCAGCCGTAGGC _B

pos_ctrl_A

Target(s)

-0.925985484

0.0062098

5.631731145

-1.521299279

-2.500327335

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q805Y1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

vIRF2_VP64_pos_ctrl_X_mid

TCTATCACAACT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.928985807

0.00599572

-3.882399261

0.02389526

-4.794463601

-2.509937684

Human target

vIRF2_VP64_pos_ctrl

TOX4

core_VP64_a

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation GGCACAGCTCCA _B

Target(s)

Target(s)

-0.307615332

0.24458972

2.246974344

0.28102262

-1.584379902

0.983066962

-2.512443507

0.384778867

Virus_target

Human target

hvTR_Q2HR71

DTX2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

Strong_x_unknown

ACTTGATGGTTT _A_Concatenation GAGTGACCTATT _B

Target(s)

Target(s)

-0.671129848

0.00228681

-2.182955645

0.10930697

0.091416746

-2.51732128

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

Mid_X_unknown

ATGACCCCTTGT _A_Concatenation CATGCTAACACC _B

Target(s)

Target(s)

0.594642942

0.81666774

3.919508603

0.01582874

-3.908267003

-2.537154046

Human target

Virus_target

LEUTX

hvTR_F5HCV3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

Strong_X_strong

CTCGTTATGGCA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.273607922

0.23167242

5.612175114

2.32E-05

0.580736127

0.997690695

-2.540269078

0.260152305

Human target

Virus_target

NOVA1

hvTR_Q2HR71

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATGACCCCTTGT _A_Concatenation TATCGCAAGAAC _B

Target(s)

neg_ctrl

-2.714682385

0.32731981

4.473977221

-2.547431136

Human target

neg_ctrl

LEUTX

Random_5

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

Strong_X_random

ATAACTCCACGC _A_Concatenation GATGGAGCTACA _B

pos_ctrl_A

Target(s)

0.495464255

0.64978462

-2.005317482

0.29907275

-2.752933464

-2.560168569

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P03209

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation TGATGAGCGCCC _B

Target(s)

Target(s)

0.075230765

0.89748071

4.653745674

0.00970884

-0.393787656

0.997690695

-2.56223596

0.384778867

Virus_target

Human target

hvTR_Q2HR73

EEF1D

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

Mid_X_weak

AATCGATCCTAC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.079841774

0.92647166

-2.290427844

0.23568834

-0.941067789

-2.562480729

Human target

Virus_target

PRDM10

hvTR_Q2HR71

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GCAACGAGGGTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.363847444

6.90E-42

6.402369057

2.81E-05

-0.633380028

0.997690695

-2.570070018

0.218195585

Human target

Virus_target

QRICH2

hvTR_Q2HR73

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CTACGTGGCCCC _A_Concatenation AGCCAGGTCACC _B

Target(s)

Target(s)

-0.758054252

0.72790325

-3.414493567

0.11534543

-2.690424561

-2.577403421

Virus_target

Human target

hvTR_Q2HR71

MESP1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

Strong_X_strong

AGGCTTCCCGCT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.513624209

0.15404651

-5.628835159

0.02654179

1.480877791

-2.595460425

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

core_VP64_a

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

Stop 2_A splice AGAGTGCGCTCT B

neg_ctrl

neg_ctrl

0.963586094

0.63402488

-2.018303147

0.41209595

-4.2557923

-2.616565868

neg_ctrl

neg_ctrl

Stop_2

Random_1

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Termination_X_random

ATGACCCCTTGT _A_Concatenation AAGCAACGATAT _B

Target(s)

Target(s)

-2.46187331

0.36954563

-3.202659801

0.22915921

-4.271318662

-2.633544451

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

Strong_X_mid

ATGACCCCTTGT _A_Concatenation Joint_ 3_B

Target(s)

neg_ctrl

-0.801163172

0.03425538

5.613509686

0.02064758

-0.178426148

-2.671038686

Human target

neg_ctrl

LEUTX

Joint_3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

Strong-X-joint

ATGTGGCACGAC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.592403851

0.47019918

-1.998318256

0.51665233

-0.475536434

-2.681127964

Human target

vIRF2_VP64_pos_ctrl

ANKRD17

core_VP64_a

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATCCAATCTGTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.495489344

0.43839885

0.616216156

0.78985304

0.024706282

-2.684664195

Human target

Virus_target

GLI2

hvTR_Q2HR71

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CATCTCACCTAG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.277546042

0.68922551

-1.309807802

0.41356717

-5.86947971

-2.686239646

Virus_target

neg_ctrl

hvTR_P03206

Random_1

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GAGATTGTGTCC _A_Concatenation TCTTGGTTTTGA _B

Target(s)

Target(s)

0.811215165

0.51346664

-3.535184037

0.22849993

2.486192349

-2.697595489

Virus_target

Human target

hvTR_Q2HR71

ZNF597

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

Strong_X_strong

CACACCCGGCAG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.909237772

0.09988704

-0.191391092

0.92368263

1.293548845

0.983636094

-2.715470866

0.159618156

Virus_target

Virus_target

hvTR_P19893

hvTR_Q2HR73

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CATTAGTCCCGC _B

Target(s)

Target(s)

-0.62190184

0.02410705

2.43158143

0.1714026

-0.346047949

0.997690695

-2.743563182

0.068273719

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P06930

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

Strong_X_strong

CTACGTGGCCCC _A_Concatenation GATCGCATGTTC _B

Target(s)

Target(s)

2.917691612

0.02319299

-1.727426017

-4.587976911

-2.755265402

Virus_target

Human target

hvTR_Q2HR71

INPP4A

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

Strong_X_strong

CTACGTGGCCCC _A_Concatenation GATGGAGCTACA _B

Target(s)

Target(s)

-1.280498165

0.04259596

-5.020768955

0.01271193

1.389927861

-2.759970942

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03209

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Strong_X_strong

CACACCCGGCAG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.342490136

0.46615283

-3.051442368

0.02709971

-0.810071219

0.997690695

-2.785211575

0.280453332

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P19893

core_VP64_a

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation CTCCATTAATGA _B

Target(s)

Target(s)

1.188324125

4.48E-11

-4.295331756

0.02754099

-0.485951148

0.997690695

-2.803612047

0.258683222

Human target

Virus_target

LEUTX

hvTR_Q5IXR3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

Strong_x_weak

AGTTAGGCTCTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.23280273

0.82490703

-2.802725841

0.16145271

-3.271339259

-2.813173301

Human target

Virus_target

TOX4

hvTR_Q2HR71

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation TTCTAATTTCCT _B

neg_ctrl

Target(s)

1.411170205

1.79E-12

5.315720744

0.00258074

0.003109429

0.998980766

-2.816877029

0.086892875

neg_ctrl

Human target

Random_1

WDR76

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

Random_x_strong

AGAGTGCGCTCT _A_Concatenation AAAACAAGCATT _B

neg_ctrl

Target(s)

-0.484999467

0.82490703

-5.351655277

0.05636543

-2.781124907

-2.819684396

neg_ctrl

Virus_target

Random_1

cds_NC_030656.1_cds_YP_009268803.1_88

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

Random_x_weak

ACTTGATGGTTT _A_Concatenation GGGAGTATGTCG _B

Target(s)

neg_ctrl

-0.497669976

0.16187644

4.55070641

0.12742137

0.124446763

0.998501722

-2.829345751

0.073394906

Virus_target

neg_ctrl

hvTR_Q2HR73

Random_4

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

Mid_X_random

AGAGTGCGCTCT _A_Concatenation CGCCGGCATACA _B

neg_ctrl

Target(s)

0.117584584

0.93141616

-7.003859706

1.015253663

-2.830095935

neg_ctrl

Virus_target

Random_1

cds_NC_030656.1_cds_YP_009268729.1_14

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

Random_x_strong

GAGATTGTGTCC _A_Concatenation CAGTGACATAGT _B

Target(s)

Target(s)

0.127786254

0.68918478

-1.67649194

0.36927388

-0.781371005

0.997690695

-2.831372634

0.161343204

Virus_target

Human target

hvTR_Q2HR71

EHMT2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

Strong_X_mid

Stop-1_A/u splice_ ATAACTCCACGC _b

neg_ctrl

pos_ctrl_A

-2.143264575

0.22130449

4.869029951

6.896949722

-2.839304524

neg_ctrl

vIRF2_VP64_pos_ctrl

Stop_1

core_VP64_a

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Termination_X_vIRF2\u VP64_pos_ctrl

TATCTATCGTGT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.843580843

0.10365221

-5.426290439

0.00382558

0.99635433

-2.847863449

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03259

core_VP64_a

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation TTAAATGAGGGC _B

Target(s)

Target(s)

-1.13633224

2.01E-11

-3.22787056

0.04126764

1.162386514

0.997690695

-2.85345889

0.098005281

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

mid_X_mid

CATTAGTCCCGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.048247658

0.94601266

0.934546223

0.52954752

1.771994733

-2.854624847

Virus_target

Virus_target

hvTR_P06930

hvTR_Q2HR71

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ACTTGATGGTTT _A_Concatenation CGATGGCGGAAT _B

Target(s)

Target(s)

-0.308847024

0.8076353

-6.088207699

0.00494879

5.05377877

-2.860304321

Virus_target

Human target

hvTR_Q2HR73

KIAA1586

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

Mid_X_weak

AGAGTGCGCTCT _A_Concatenation TCTTAGAGGGTG _B

neg_ctrl

Target(s)

-0.848396207

0.12195933

-1.383589548

0.15230837

-0.979860418

-2.866564914

neg_ctrl

Human target

Random_1

TRO

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

Random_x_strong

CTCCATTAATGA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

2.335009095

0.68153204

-3.748197923

0.14927325

-3.085450818

-2.898929433

Virus_target

Virus_target

hvTR_Q5IXR3

hvTR_Q2HR71

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

ATGACAAAACGA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.144011117

0.91324404

-3.510311754

0.03000685

-0.257512374

-2.900221639

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094074.1_1

core_VP64_a

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ATCTCTCAGTTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.271740283

0.82433714

-0.650581306

0.76446307

0.86694187

-2.909138674

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

hvTR_Q2HR73

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ACTTGATGGTTT _A_Concatenation AGCCGTGCTTGA _B

Target(s)

Target(s)

0.50318991

0.78044287

-4.279880806

0.15534321

-4.265174781

-2.922804022

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

Mid_X_weak

AGAGTGCGCTCT _A_Concatenation CTGGTAGTTGTT _B

neg_ctrl

Target(s)

-0.183699853

0.52901596

2.005003881

0.19050027

-0.831108259

0.997690695

-2.934145051

0.064747465

neg_ctrl

Virus_target

Random_1

hvTR_F6KS47

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

Random_x_unknown

CTACGTGGCCCC _A_Concatenation AATCAACGAGCA _B

Target(s)

Target(s)

-0.964038414

0.04988573

-1.265804476

0.58359133

1.765071327

-2.946414793

Virus_target

Human target

hvTR_Q2HR71

C2orf81

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

Strong_X_strong

CTCACGACAAGA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.431113823

0.35403027

-1.386833841

0.18271773

-1.52861824

-2.951658494

Virus_target

neg_ctrl

hvTR_G3G929

Random_1

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATGACCCCTTGT _A_Concatenation CTGGTAGTTGTT _B

Target(s)

Target(s)

1.716816365

2.73E-21

5.061750345

0.02500981

-0.54619243

0.997690695

-2.954588117

0.054928629

Human target

Virus_target

LEUTX

hvTR_F6KS47

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

Strong_x_unknown

TTAGTGCCATAC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.967237371

0.73293852

-4.064036569

0.18034078

-4.795333136

-2.977658898

Human target

Virus_target

TET3

hvTR_Q2HR73

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ACTTGATGGTTT _A_Concatenation CTCCATTAATGA _B

Target(s)

Target(s)

1.519270995

0.00011961

-4.878494401

0.01993997

-1.742377961

-3.00218938

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q5IXR3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

Mid_X_weak

Stop 2_A splice CTACGTGGCCCC B

neg_ctrl

Target(s)

1.218406888

0.03952651

3.537343208

0.09700536

-0.544321389

-3.005570369

neg_ctrl

Virus_target

Stop_2

hvTR_Q2HR71

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Termination_X_strong

ATAACTCCACGC _A_Concatenation CCCTATGTTCTA _B

pos_ctrl_A

pos_ctrl_A

-1.202985609

0.12526619

-5.178078371

0.0014569

-0.82052246

-3.008285978

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_a

core_VP64_b

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation CTGGTAGTTGTT _B

Target(s)

Target(s)

-0.825142393

0.05692167

2.720373731

0.18438168

-1.48747893

0.983636094

-3.020029545

0.205419389

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_F6KS47

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

Mid_X_unknown

ATGACCCCTTGT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.304532773

0.59969203

0.801636924

0.70172052

0.814126051

-3.037549519

Human target

neg_ctrl

LEUTX

Random_1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

GAGATTGTGTCC _A_Concatenation CATCTCACCTAG _B

Target(s)

Target(s)

0.686023462

0.45505484

6.966409082

-1.759358179

0.957192732

-3.050692888

0.211428465

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03206

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

Strong_X_mid

GATCGCATGTTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.982882923

4.06E-08

4.183099174

3.89E-05

0.422317832

0.997690695

-3.052933094

0.054928629

Human target

vIRF2_VP64_pos_ctrl

INPP4A

core_VP64_a

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation TTAAATGAGGGC _B

Target(s)

Target(s)

-1.298638283

0.00217071

-5.705827603

0.0007807

1.354254213

0.997690695

-3.057312812

0.211428465

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

Strong_X_mid

AGTTGCTTTGCT _A_Concatenation ACTTGATGGTTT _B

neg_ctrl

Target(s)

-1.350380742

1.40E-07

0.355584788

0.85606566

-0.293709075

-3.059777805

neg_ctrl

Virus_target

Random_2

hvTR_Q2HR73

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Random_x_mid

CTACGTGGCCCC _A_Concatenation AAGCAACGATAT _B

Target(s)

Target(s)

1.094009999

5.52E-06

6.494286403

0.01006861

0.811125418

-3.065469968

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

Strong_X_mid

TACTTCTAGCGG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.151596557

0.938493

-7.862570519

0.00036537

-1.029667825

-3.067912365

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094080.1_7

core_VP64_a

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

CATTGTTTAAAT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.218479038

1.21E-16

6.552754655

8.16E-10

0.345160713

0.997690695

-3.068474652

0.023419491

Human target

neg_ctrl

POLR1E

Random_1

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

ATGACCCCTTGT _A_Concatenation AGTTGCTTTGCT _B

Target(s)

neg_ctrl

-1.861610725

0.07185248

-4.563821822

0.00839444

-4.646610972

-3.071920647

Human target

neg_ctrl

LEUTX

Random_2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

Strong_X_random

ACTTGATGGTTT _A_Concatenation CATCTCACCTAG _B

Target(s)

Target(s)

-1.285502444

0.01709348

-5.095976669

0.00032685

1.103695803

0.997690695

-3.072739532

0.110683896

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P03206

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

mid_X_mid

CCAGACGGTCTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.615200079

0.85449119

-3.308899494

0.19711662

5.253949757

-3.076787965

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

hvTR_Q2HR71

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

AGTTAGGCTCTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.12078446

0.90192409

-7.672694834

3.95E-07

0.648914138

0.997690695

-3.077019686

0.134152071

Human target

vIRF2_VP64_pos_ctrl

TOX4

core_VP64_a

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation ATCTCTCAGTTC _B

Target(s)

Target(s)

-1.811352055

0.00049548

4.069358341

-0.222888413

-3.079298905

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CCTAAATGCAAG _B

Target(s)

Target(s)

-1.018508068

0.80528278

-5.727663605

0.00295126

-0.404926024

-3.081335489

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025410.1_cds_YP_009094498.1_7

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

Strong_X_mid

ATAACTCCACGC _A_Concatenation ACGGCGTAAGTA _B

pos_ctrl_A

Target(s)

-0.530880658

0.63990277

-5.489713721

0.08135871

1.725701765

-3.08417375

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_025350.1_cds_YP_009094078.1_5

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

vIRF2_VP64_pos_ctrl_X_mid

CATGCTAACACC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-2.492169409

0.00050712

-5.646672883

6.47E-05

-0.241498479

0.998501722

-3.111346665

Virus_target

Virus_target

hvTR_F5HCV3

hvTR_Q2HR71

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CTACGTGGCCCC _A_Concatenation GGTGTCTCGATT _B

Target(s)

Target(s)

0.834420633

3.08E-06

0.713809255

1.427687102

0.972639657

-3.111461165

0.083931183

Virus_target

Human target

hvTR_Q2HR71

E2F5

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

Strong_X_strong

ATAACTCCACGC _A_Concatenation AATCGAGACCAG _B

pos_ctrl_A

Target(s)

0.590019143

0.77397082

-5.10389896

0.130578301

-3.12022939

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q8BB47

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

VIRF2_VP64_pos strong_ctrl_x_strong

GAGATTGTGTCC _A_Concatenation GCGAGGCAGACC _B

Target(s)

Target(s)

0.492449462

0.4982603

-2.902394156

0.10515713

-1.633450088

-3.126196665

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

Strong_x_unknown

CTGCCGGTTGCG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.844235861

1.89E-05

3.592881517

0.00139746

0.339318031

0.997690695

-3.129815647

0.054928629

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

hvTR_Q2HR73

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CTACGTGGCCCC _A_Concatenation TAAAATTTATCA _B

Target(s)

Target(s)

-0.267250699

0.48822994

-3.025519692

0.03676889

0.934511497

0.997690695

-3.136670141

0.191530223

Virus_target

Human target

hvTR_Q2HR71

HSF1

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

Strong_X_mid

GGTGTCTCGATT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.04415163

8.14E-07

3.394559837

0.11423327

-4.484412352

-3.158066027

Human target

Virus_target

E2F5

hvTR_Q2HR71

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CTCAGCGATATA _B

Target(s)

Target(s)

1.097030107

6.26E-17

2.804685847

0.16314825

-0.267587193

0.998501722

-3.186515624

0.086749068

Human target

Virus_target

LEUTX

hvTR_Q5Y0Q4

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

Strong_X_strong

ATTTGTAGACCG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.749842212

0.09842699

-0.635733599

0.70334265

-0.125147804

0.998501722

-3.188892811

0.193267146

Human target

Virus_target

MYCN

hvTR_Q2HR71

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ATGACCCCTTGT _A_Concatenation Joint_ 2_B

Target(s)

neg_ctrl

0.943193695

0.37874388

-5.349415963

0.173433765

-3.190062317

Human target

neg_ctrl

LEUTX

Joint_2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

Strong-X-joint

ATTGTATCTAAC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.521136808

0.28403057

-5.91187531

0.00022359

-0.109334128

0.998501722

-3.192965838

0.058225543

Human target

vIRF2_VP64_pos_ctrl

SMARCB1

core_VP64_a

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation CTCAGCGATATA _B

pos_ctrl_A

Target(s)

-0.127635881

0.88732067

-6.329275937

0.00062712

0.800093013

0.997690695

-3.194500067

0.174791142

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q5Y0Q4

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation ATGACCCCTTGT _B

pos_ctrl_A

Target(s)

1.196056268

0.00013723

4.821823203

0.00297318

-0.298519192

0.997690695

-3.210595196

0.054928629

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

LEUTX

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation ATTTGTAGACCG _B

Target(s)

Target(s)

-0.379243617

0.42479369

6.324512747

0.01057624

-0.774921043

0.997690695

-3.212016361

0.107214215

Virus_target

Human target

hvTR_Q2HR73

MYCN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

mid_X_mid

CTCGCACCGAGG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-3.323846571

0.01109663

-4.514996773

0.0362745

0.419970377

-3.225452222

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

hvTR_Q2HR73

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TTCTAATTTCCT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.667813081

0.61505192

-3.965846202

0.09576001

-1.01450497

-3.260085709

Human target

Human target

WDR76

LEUTX

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ATGTGGCACGAC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.135636892

8.72E-05

4.505772863

0.08025707

-5.060456231

-3.260502868

Human target

Virus_target

ANKRD17

hvTR_Q2HR71

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ACAACGTGCATA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.45029505

0.13870201

2.215866379

0.26366269

-0.335065007

0.997690695

-3.264892208

0.110773865

Virus_target

Virus_target

hvTR_P10407

hvTR_Q2HR73

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CCCGTAGGGGCT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.089603055

0.18459129

-6.079059187

0.02861473

1.039295762

-3.265186069

Human target

Virus_target

TET3

hvTR_Q2HR73

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CGGCAATTGCTT _B

Target(s)

Target(s)

-6.052597244

0.00073643

-6.828004345

0.03413661

-4.584875173

-3.265443042

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q9QB93

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

Strong_X_mid

CCAGACGGTCTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.165809915

0.04327849

1.159888611

-4.380086588

-3.270620434

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

core_VP64_a

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

ATCTCTCAGTTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.01568368

0.96871881

-5.239788742

0.00021381

0.649623342

0.997690695

-3.274385262

0.229030263

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

hvTR_Q2HR71

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

Joint_ 3_A/u splice_ CTACGTGGCCCC _b

neg_ctrl

Target(s)

0.164852824

0.8912779

4.600553386

0.03687635

0.003348726

0.998980766

-3.278363081

0.131471919

neg_ctrl

Virus_target

Joint_3

hvTR_Q2HR71

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Joint_X_strong

ATAACTCCACGC _A_Concatenation Stop_1_B

pos_ctrl_A

neg_ctrl

-3.197038046

4.21E-08

-4.555037765

0.00375262

-0.173801051

0.998501722

-3.289675393

0.049877065

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Stop_1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

VIRF2_VP64_pos ctrl X termination

CTCGCACCGAGG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.45448228

0.88732067

-2.685901243

0.41999825

5.452786141

-3.290701355

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

LEUTX

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGATTGTGTCC _A_Concatenation AAGCAACGATAT _B

Target(s)

Target(s)

-0.669449747

0.1798316

6.907790607

0.00666775

0.529309322

0.997690695

-3.296605862

0.05862272

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CTCAGCGATATA _B

Target(s)

Target(s)

-0.076016779

0.83433135

-5.130763938

0.00446269

-0.024053504

-3.315756982

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q5Y0Q4

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

Strong_X_strong

ATGACCCCTTGT _A_Concatenation Joint_ 1_B

Target(s)

neg_ctrl

0.813103962

0.03658197

4.939173144

0.04947198

2.605045529

0.641409749

-3.32587358

0.12609254

Human target

neg_ctrl

LEUTX

Joint_1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

Strong-X-joint

AATCGATCCTAC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.963963532

0.49700987

-0.160156745

0.95325468

2.250737289

-3.336153261

Human target

Human target

PRDM10

LEUTX

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATGACAAAACGA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.313327005

0.88092648

-0.912905208

0.75669327

3.967333369

-3.345384948

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094074.1_1

hvTR_Q2HR71

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATAACTCCACGC _A_Concatenation GGGAGTATGTCG _B

pos_ctrl_A

neg_ctrl

0.573628312

0.19477654

-8.044820843

2.81E-06

-1.196891664

0.997690695

-3.361903051

0.080335482

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Random_4

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

VIRF2_VP64_pos ctrl_x_random

ATAACTCCACGC _A_Concatenation TCTTGGTTTTGA _B

pos_ctrl_A

Target(s)

0.086234301

0.82429662

1.100267813

-0.012188578

0.998980766

-3.368062312

0.194369637

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ZNF597

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

VIRF2_VP64_pos strong_ctrl_x_strong

AGTTAGGCTCTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.731059336

0.55882961

-3.79691003

0.06620989

0.761174149

-3.368710217

Human target

Virus_target

TOX4

hvTR_Q2HR71

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CTACGTGGCCCC _A_Concatenation EPICXV.47_B

Target(s)

pos_ctrl_A

1.007126726

0.01046123

3.707241978

0.13230718

-0.192815431

0.998501722

-3.370810444

0.171371711

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

3x_vIRF2_core

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation TACATGAGGCAC _B

neg_ctrl

Target(s)

1.192247794

0.3372476

-3.427227671

0.13890003

-3.217737725

-3.377194595

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

Random_x_mid

ATGACCCCTTGT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.762926013

0.17494383

-2.844999363

0.01939364

1.797972435

-3.379320574

Human target

Virus_target

LEUTX

hvTR_Q2HR71

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation GGCACTGTCGAG _B

neg_ctrl

Target(s)

-0.042917269

0.94626231

-3.015525805

0.06816441

-0.928456295

-3.384933635

neg_ctrl

Virus_target

Random_1

hvTR_P17147

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

Random_x_unknown

CTACGTGGCCCC _A_Concatenation CACACCCGGCAG _B

Target(s)

Target(s)

0.216736719

0.16187644

-2.577040087

0.06073326

0.036781643

0.998501722

-3.397764828

0.016202253

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P19893

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

Strong_X_strong

CCCTATGTTCTA _A_Concatenation GAGATTGTGTCC _B

pos_ctrl_A

Target(s)

-0.314379072

0.42479369

0.650841616

0.219982754

0.998501722

-3.398785988

0.052103508

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q2HR71

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VIRF2_VP64_pos strong_ctrl_x_strong

AAAACAAGCATT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.688905208

0.00025938

-3.360172907

0.01063608

-1.670358502

-3.404751699

Virus_target

neg_ctrl

cds_NC_030656.1_cds_YP_009268803.1_88

Random_1

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

AAACTTTGAGCG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.278542152

0.84320905

-1.408856941

0.45340354

-1.50689216

-3.432815574

Human target

neg_ctrl

ATF6B

Random_1

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AAGGGTAAATTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.17786516

0.93141616

-6.293008667

0.01357904

1.182260225

-3.436016481

Virus_target

Virus_target

hvTR_Q69513

hvTR_Q2HR71

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation GCGAGGCAGACC _B

neg_ctrl

Target(s)

0.718903331

0.73105591

-2.732505785

0.27878253

3.837640285

-3.443009776

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

Random_x_unknown

CTCGCACCGAGG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.412091989

0.53947462

0.157331695

0.95625121

-0.143428538

-3.464063231

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

core_VP64_a

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

TCTTAGAGGGTG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.2876255

0.89850726

-2.415935648

0.03743675

0.630481138

0.997690695

-3.469121613

0.122424827

Human target

Virus_target

TRO

hvTR_Q2HR71

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

GAGACAGCTCTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-3.342400535

0.09772997

1.594059168

0.47823298

1.831897655

-3.472937637

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

hvTR_Q2HR73

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

AGAGTGCGCTCT _A_Concatenation ATCTCTCAGTTC _B

neg_ctrl

Target(s)

-0.864333359

0.4351538

-6.713042351

0.02599858

0.602283101

-3.474009871

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

Random_x_mid

CTACGTGGCCCC _A_Concatenation CATGCTAACACC _B

Target(s)

Target(s)

-0.818417629

0.1377177

-2.30486022

0.08674401

-0.058724582

-3.474168444

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_F5HCV3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

Strong_X_strong

TACATGAGGCAC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.692110308

0.32544126

-0.577254422

-4.584638333

-3.486914102

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

core_VP64_a

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CTCGTTATGGCA _B

neg_ctrl

Target(s)

0.173779365

0.83608193

-1.051383851

0.56865938

-1.376003423

0.976975145

-3.489524749

0.048359833

neg_ctrl

Human target

Random_1

NOVA1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

Random_x_mid

AATCGATCCTAC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.049958356

0.00126147

9.487271902

1.175916714

0.997690695

-3.509388405

0.042736939

Human target

vIRF2_VP64_pos_ctrl

PRDM10

core_VP64_a

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTCGTTATGGCA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-4.637421856

0.03648591

-0.39615249

0.83938517

5.368640331

-3.525668097

Human target

Human target

NOVA1

LEUTX

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATAACTCCACGC _A_Concatenation GTTCCACGCCTG _B

pos_ctrl_A

Target(s)

-0.773343219

0.1062238

-4.298906826

0.00036537

-1.132292516

0.997690695

-3.535330836

0.161906702

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

ZFX

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

VIRF2_VP64_pos strong_ctrl_x_strong

ATGACCCCTTGT _A_Concatenation TGCCAGACGGTC _B

Target(s)

Target(s)

-0.580246927

0.17468281

-4.446449782

0.00124469

1.696276859

0.933317674

-3.547839857

0.075672673

Human target

Virus_target

LEUTX

hvTR_P10541

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

Strong_X_strong

CTACGTGGCCCC _A_Concatenation ACCAGTATTTAA _B

Target(s)

Target(s)

-0.512887799

0.68632574

0.236257054

0.92289832

-3.533417813

-3.550591276

Virus_target

Human target

hvTR_Q2HR71

ARNTL2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Strong_X_strong

CGCCGGCATACA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.283743784

0.32731981

-1.462077707

0.50612999

5.700280002

-3.555425566

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_030656.1_cds_YP_009268729.1_14

core_VP64_a

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation AATCAACGAGCA _B

Target(s)

Target(s)

0.576792467

0.1062238

4.500577866

1.084154525

-3.564313779

Virus_target

Human target

hvTR_Q2HR73

C2orf81

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation ACTTGATGGTTT _B

neg_ctrl

Target(s)

0.530221894

0.12515795

-2.717551591

0.02599858

1.324298725

0.997690695

-3.578364752

0.155492795

neg_ctrl

Virus_target

Random_1

hvTR_Q2HR73

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Random_x_mid

CATTGTTTAAAT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.835465514

0.49700987

0.339564461

0.87357617

-4.674698983

-3.581817625

Human target

vIRF2_VP64_pos_ctrl

POLR1E

core_VP64_a

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation ACAACGTGCATA _B

Target(s)

Target(s)

-1.244494939

0.00704318

1.178333642

0.62151298

1.77196288

0.95807515

-3.58973331

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P10407

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

Strong_X_strong

ATGACCCCTTGT _A_Concatenation GAGTGACCTATT _B

Target(s)

Target(s)

-0.400364151

0.2999327

5.61748582

0.707787252

0.997690695

-3.60294566

0.217836052

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

Strong_x_unknown

ATGACCCCTTGT _A_Concatenation AATCGATCCTAC _B

Target(s)

Target(s)

0.232010284

0.926639

-6.645734503

0.00323548

-1.936911862

-3.604186115

Human target

Human target

LEUTX

PRDM10

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

Strong_X_mid

ATGACCCCTTGT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.480100889

0.43839885

-1.611388088

0.33839065

1.146522549

-3.618098542

Human target

Human target

LEUTX

LEUTX

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CCCCTTAGGAAT _B

Target(s)

Target(s)

-1.3128433

0.47888775

-1.293041477

0.52828339

-0.544043511

-3.626863716

Virus_target

Human target

hvTR_Q2HR71

SYNE1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

Strong_X_mid

TCTTAGAGGGTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.637131899

0.30031597

0.241076509

0.92185818

0.407037687

0.997690695

-3.633545219

0.040091246

Human target

vIRF2_VP64_pos_ctrl

TRO

core_VP64_a

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

TATCTATCGTGT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.689609008

0.17494383

-6.342547418

0.00384211

1.822257758

-3.655908322

Virus_target

Virus_target

hvTR_P03259

hvTR_Q2HR73

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

TAAGATTCAACG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.448014329

0.13204496

-0.880708036

-1.952075864

0.871241789

-3.678840321

0.080335482

Human target

vIRF2_VP64_pos_ctrl

ZNF292

core_VP64_a

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CACACCCGGCAG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.266530591

0.70051124

-3.990169607

0.00617968

0.050584658

0.998501722

-3.686987915

0.099717208

Virus_target

neg_ctrl

hvTR_P19893

Random_1

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation CTCACGACAAGA _B

pos_ctrl_A

Target(s)

0.980727933

0.49700987

6.097640698

0.03872928

-1.336229445

-3.689236542

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_G3G929

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

VIRF2_VP64_pos strong_ctrl_x_strong

AGAGTGCGCTCT _A_Concatenation AATCAACGAGCA _B

neg_ctrl

Target(s)

-0.646476721

2.35E-06

5.656919127

0.00011919

-0.426309354

0.997690695

-3.694463267

0.047067196

neg_ctrl

Human target

Random_1

C2orf81

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

Random_x_strong

GAGATTGTGTCC _A_Concatenation GTACATACCGAA _B

Target(s)

Target(s)

-0.643526712

0.29409568

-1.189378627

0.50792395

1.03524989

0.997690695

-3.705909936

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

Strong_X_mid

GAGATTGTGTCC _A_Concatenation TGATGAGCGCCC _B

Target(s)

Target(s)

-1.352781981

5.86E-06

-4.049104912

0.0015566

-0.691425996

0.997690695

-3.718711591

0.099717208

Virus_target

Human target

hvTR_Q2HR71

EEF1D

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

Strong_x_weak

ATAACTCCACGC _A_Concatenation TTAAATGAGGGC _B

pos_ctrl_A

Target(s)

-0.823409028

0.42955596

-5.06348277

0.11429869

2.662552567

-3.723408855

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

vIRF2_VP64_pos_ctrl_X_mid

TTCTAATTTCCT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.457972733

0.58023965

-0.161317346

0.94116917

-0.938580974

0.997690695

-3.725932057

Human target

vIRF2_VP64_pos_ctrl

WDR76

core_VP64_a

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation TATCTATCGTGT _B

neg_ctrl

Target(s)

-1.950881502

0.50140379

-5.125638167

0.10980349

0.861729516

-3.734216621

neg_ctrl

Virus_target

Random_1

hvTR_P03259

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

Random_x_strong

CCCCTTAGGAAT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.120319609

0.47726148

-4.614605373

0.16671372

-1.358125308

-3.740512405

Human target

vIRF2_VP64_pos_ctrl

SYNE1

core_VP64_a

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation AAGCAACGATAT _B

Target(s)

Target(s)

-0.801175474

0.125695

4.55752475

0.04902037

0.628001121

0.997690695

-3.743860036

0.097385987

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

mid_X_mid

GACTGTGGGCGG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.772620133

0.00054963

-4.973040189

0.00022359

-3.114821294

-3.746590357

Human target

Human target

MON2

LEUTX

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

CTACGTGGCCCC _A_Concatenation CAACGCATGCCT _B

Target(s)

Target(s)

0.053284434

0.93141616

-3.943712612

0.00744155

0.269043499

-3.75414495

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

Strong_x_weak

TTTAACGGATTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.54843765

0.82067579

-3.428579929

5.889814059

-3.757053539

Human target

Human target

TWIST2

LEUTX

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

GAGATTGTGTCC _A_Concatenation GCAGATTCGAAT _B

Target(s)

Target(s)

-0.220587267

0.7246252

-5.562168437

0.00045446

1.558851595

-3.77615265

Virus_target

Human target

hvTR_Q2HR71

AK9

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

Strong_X_mid

CGATGGCGGAAT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-2.138343323

0.31988807

-4.262742693

0.08285043

0.050015017

0.998501722

-3.777927404

Human target

neg_ctrl

KIAA1586

Random_1

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

ATAACTCCACGC _A_Concatenation CTGGTAGTTGTT _B

pos_ctrl_A

Target(s)

-0.427407666

0.37756408

-2.719237711

0.07789462

0.341208374

0.997690695

-3.778427356

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_F6KS47

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

VIRF2_VP64_pos ctrl_x_unknown

CTCGCACCGAGG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.16944363

0.60940534

-5.358788402

0.12197421

0.427880614

-3.783271352

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

hvTR_Q2HR71

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATAACTCCACGC _A_Concatenation TATCTATCGTGT _B

pos_ctrl_A

Target(s)

1.58312524

5.60E-11

-4.376514787

0.00989082

-0.224946785

0.998501722

-3.796688035

0.099589021

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_P03259

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

VIRF2_VP64_pos strong_ctrl_x_strong

ACTTGATGGTTT _A_Concatenation ACTTTAGTAACA _B

Target(s)

Target(s)

0.996242005

0.03520409

1.444173994

0.48796824

-1.70599625

0.968300879

-3.797034319

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_Q69113

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

Mid_X_strong

CCCGTAGGGGCT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.905319337

0.36741802

-1.692605498

0.56400389

-5.357696162

-3.804657816

Human target

neg_ctrl

TET3

Random_1

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ACTTGATGGTTT _A_Concatenation ACGACTCACCGC _B

Target(s)

Target(s)

-0.800443739

0.31287443

-5.202049668

0.00062712

0.734507729

-3.810916499

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

mid_X_mid

CTACGTGGCCCC _A_Concatenation CATCTCACCTAG _B

Target(s)

Target(s)

-0.179641186

0.67964161

-2.155426746

0.11790489

-0.302240454

0.998501722

-3.819152178

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03206

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

Strong_X_mid

ATGACCCCTTGT _A_Concatenation TCTTGGTTTTGA _B

Target(s)

Target(s)

0.620289785

0.13290849

-3.927459134

0.01736975

3.689092628

0.527905197

-3.824635546

Human target

Human target

LEUTX

ZNF597

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

Strong_X_strong

TGGCCCCCAGTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.015673306

0.99110789

0.320553487

0.91072633

3.613227319

-3.828897252

Virus_target

neg_ctrl

hvTR_Q3I8P6

Random_1

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

GGCACAGCTCCA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.202206027

0.00018332

0.09390313

0.95756877

-0.380359541

0.997690695

-3.841579357

0.097929575

Human target

Virus_target

DTX2

hvTR_Q2HR71

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

AATGGCACTAGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.906448177

1.18E-08

5.533529207

0.00015784

-0.315447609

0.997690695

-3.858380444

0.018312917

Virus_target

neg_ctrl

cds_NC_024711.1_cds_YP_009052522.2_44

Random_1

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

ATAACTCCACGC _A_Concatenation GAGACAGCTCTC _B

pos_ctrl_A

Target(s)

-0.481687015

0.4982603

-3.650428503

0.02198039

5.993644316

-3.867124733

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

vIRF2_VP64_pos_ctrl_X_mid

AAAACAAGCATT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.798498462

7.13787243

0.00081729

-3.659571355

-3.87502489

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268803.1_88

hvTR_Q2HR73

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

TGGCCCCCAGTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.106423079

0.93202829

-5.530031353

0.00062354

-0.602435632

-3.879971756

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q3I8P6

core_VP64_a

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation GAGATTGTGTCC _B

neg_ctrl

Target(s)

-0.674097894

0.19037284

2.79170925

0.16081235

0.23263875

0.998501722

-3.902234996

0.074608262

neg_ctrl

Virus_target

Random_1

hvTR_Q2HR71

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Random_x_strong

CTACGTGGCCCC _A_Concatenation AAGGGTAAATTG _B

Target(s)

Target(s)

1.076529483

0.32392216

-0.899522646

0.56137619

2.253647148

-3.91002615

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q69513

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

Strong_X_mid

ACTTGATGGTTT _A_Concatenation GGCACTGTCGAG _B

Target(s)

Target(s)

-0.591566378

0.17962689

0.926423412

0.62046092

1.873513353

0.87819447

-3.915044125

0.044551217

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P17147

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

Mid_X_unknown

ATGACCCCTTGT _A_Concatenation TATCTATCGTGT _B

Target(s)

Target(s)

1.067172311

0.26797115

-4.353100344

-2.531223211

-3.918412794

Human target

Virus_target

LEUTX

hvTR_P03259

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

Strong_X_strong

ATAACTCCACGC _A_Concatenation GGAGGCACATCG _B

pos_ctrl_A

Target(s)

-0.805834731

0.02784752

-4.110977358

0.00325151

-0.53407454

0.997690695

-3.920799938

0.073394906

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q87042

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AGAGTGCGCTCT _B

pos_ctrl_A

neg_ctrl

-0.714238038

0.5677544

-3.93081177

0.03336571

-2.850743032

0.61634714

-3.943523579

0.098005281

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Random_1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VIRF2_VP64_pos ctrl_x_random

GAGATTGTGTCC _A_Concatenation AGCCAGGTCACC _B

Target(s)

Target(s)

-0.49631591

0.80691093

-6.008724151

-5.707374122

-3.944028045

Virus_target

Human target

hvTR_Q2HR71

MESP1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

Strong_X_strong

AGAGTGCGCTCT _A_Concatenation AGCCATAAACCT _B

neg_ctrl

Target(s)

0.4608457

0.34346149

5.284951234

0.00476047

-2.230991344

0.871241789

-3.945381817

0.118786226

neg_ctrl

Virus_target

Random_1

hvTR_P03209

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

Random_x_mid

AGAGTGCGCTCT _A_Concatenation TGGCCCCCAGTT _B

neg_ctrl

Target(s)

-0.301685533

0.80366344

-8.984482903

6.86E-05

1.287036266

0.997690695

-3.964122716

0.096401552

neg_ctrl

Virus_target

Random_1

hvTR_Q3I8P6

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

Random_x_weak

Joint_1_A/u splice_ ATAACTCCACGC _b

neg_ctrl

pos_ctrl_A

1.582635864

0.00060993

-5.966827963

0.00304453

1.035310647

0.997690695

-3.972185084

0.086227003

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_1

core_VP64_a

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Linker_X_vIRF2\u VP64_pos_ctrl

ATAACTCCACGC _A_Concatenation TGATGAGCGCCC _B

pos_ctrl_A

Target(s)

-0.6126788

0.04988573

1.070975148

-0.38193355

0.997690695

-3.98390621

0.070764812

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

EEF1D

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

VIRF2_VP64_pos ctrl_x_weak

ATAACTCCACGC _A_Concatenation TTTAACGGATTG _B

pos_ctrl_A

Target(s)

1.115675665

0.02103552

-6.186166974

0.00041064

0.703026163

0.997690695

-4.00151587

0.084897118

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TWIST2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

vIRF2_VP64_pos_ctrl_X_mid

ATGACCCCTTGT _A_Concatenation TTTAACGGATTG _B

Target(s)

Target(s)

-0.176088537

0.80366344

-4.93455098

0.02336695

-1.320481332

-4.004270859

Human target

Human target

LEUTX

TWIST2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

Strong_X_mid

ACTTGATGGTTT _A_Concatenation AGCCAGGTCACC _B

Target(s)

Target(s)

0.338832768

0.32167475

3.470136275

0.08834294

0.587589748

0.997690695

-4.010689266

0.123348654

Virus_target

Human target

hvTR_Q2HR73

MESP1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

Mid_X_strong

GAGATTGTGTCC _A_Concatenation TACATGAGGCAC _B

Target(s)

Target(s)

0.492050281

0.43798565

-7.407708202

0.00015636

0.942806653

0.997690695

-4.034469668

0.079863392

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

Strong_X_mid

GGTGTCTCGATT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.590327615

0.25403675

-4.558827492

0.10327598

5.849586965

-4.041024196

Human target

Human target

E2F5

LEUTX

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

CTCAGCGATATA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.62827002

0.10744393

2.083278556

0.3594206

0.668893632

0.997690695

-4.050059979

0.025922119

Virus_target

Virus_target

hvTR_Q5Y0Q4

hvTR_Q2HR71

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CACACCCGGCAG _B

Target(s)

Target(s)

-0.285192534

0.26523132

1.935991004

-0.139665739

0.998501722

-4.052188304

0.017149591

Human target

Virus_target

LEUTX

hvTR_P19893

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

Strong_X_strong

ACCAGTATTTAA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.275105314

0.92466263

-1.402860244

0.59652223

-3.893101576

-4.052936796

Human target

vIRF2_VP64_pos_ctrl

ARNTL2

core_VP64_a

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation ATTGTATCTAAC _B

Target(s)

Target(s)

0.160830338

0.93141616

-3.808096085

0.10327598

1.623182714

-4.053970079

Virus_target

Human target

hvTR_Q2HR71

SMARCB1

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

Strong_X_mid

ATAACTCCACGC _A_Concatenation TACTTCTAGCGG _B

pos_ctrl_A

Target(s)

-0.056309314

0.95906455

-2.000026211

0.44249238

-0.430709651

-4.059116306

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NC_025350.1_cds_YP_009094080.1_7

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

VIRF2_VP64_pos ctrl_x_weak

CCCGTAGGGGCT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.2796052

0.00086021

-5.792539794

0.00151048

-2.692799123

-4.066418712

Human target

Virus_target

TET3

hvTR_Q2HR71

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

ATGACCCCTTGT _A_Concatenation TCTGTACCAACG _B

Target(s)

Target(s)

0.188482346

0.89748071

-2.302223788

0.07868483

0.484522639

-4.074166357

Human target

Virus_target

LEUTX

hvTR_Q6XA69

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

Strong_x_unknown

CTACGTGGCCCC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.24198567

0.60940534

-4.202328901

0.01582874

-0.160284125

-4.098115076

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

core_VP64_a

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

GATGGAGCTACA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.201843432

0.93141616

5.537111208

-0.265451173

-4.100241184

Virus_target

Human target

hvTR_P03209

LEUTX

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ATGACCCCTTGT _A_Concatenation GCAGATTCGAAT _B

Target(s)

Target(s)

-0.734452978

0.36774226

6.313016762

-0.776312246

-4.109608132

Human target

Human target

LEUTX

AK9

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation TCTGTACCAACG _B

neg_ctrl

Target(s)

0.073847045

0.88448623

2.299814527

0.16351831

0.395707328

0.997690695

-4.122965374

0.00459902

neg_ctrl

Virus_target

Random_1

hvTR_Q6XA69

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

Random_x_unknown

CTACGTGGCCCC _A_Concatenation GGGAGTATGTCG _B

Target(s)

neg_ctrl

-2.792199679

0.0009267

-5.139429832

0.00108214

0.620735162

-4.130764343

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_4

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

Strong_X_random

GAGATTGTGTCC _A_Concatenation CTGCCGGTTGCG _B

Target(s)

Target(s)

-0.280741111

0.32544126

-0.833291201

0.6234516

0.543504842

0.997690695

-4.131180594

0.010952256

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

Strong_X_mid

ATGACCCCTTGT _A_Concatenation CAACGCATGCCT _B

Target(s)

Target(s)

-1.51172316

0.34674225

-1.004390453

0.68250789

6.252443388

-4.140371676

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

Strong_x_weak

AGTTAGGCTCTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.040760281

0.5677544

-2.063096035

0.34736481

4.532116611

-4.155895166

Human target

Human target

TOX4

LEUTX

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation CCCTGCCTCGGG _B

neg_ctrl

Target(s)

0.18186396

0.78182953

5.080091682

0.04336342

-0.108493246

0.998501722

-4.162954253

0.012582029

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

Random_x_mid

AATGGCACTAGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.845733921

0.70546103

0.637125934

0.75004294

-5.928841198

-4.176108208

Virus_target

Virus_target

cds_NC_024711.1_cds_YP_009052522.2_44

hvTR_Q2HR71

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

CTACGTGGCCCC _A_Concatenation CTCACGACAAGA _B

Target(s)

Target(s)

0.544075071

0.49700987

-5.74881905

0.00370107

0.114722233

-4.204987887

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_G3G929

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CTCCATTAATGA _B

Target(s)

Target(s)

-0.912131903

0.26992692

-6.499557261

8.78E-05

2.571038725

-4.213550419

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q5IXR3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

Strong_x_weak

TATCTATCGTGT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.467924227

0.56644316

-5.719936407

0.01229306

0.600347348

-4.220508632

Virus_target

Virus_target

hvTR_P03259

hvTR_Q2HR71

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GGCCTTTCGGGC _A_Concatenation AGAGTGCGCTCT _B

neg_ctrl

neg_ctrl

-0.267805507

0.57362051

2.087424848

0.33875688

0.106428205

0.998501722

-4.223374225

0.054917192

neg_ctrl

neg_ctrl

Random_3

Random_1

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Random_x_random

AAAACAAGCATT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.941606828

0.07087739

4.250601266

0.02389526

-0.249476299

-4.225114733

Virus_target

Virus_target

cds_NC_030656.1_cds_YP_009268803.1_88

hvTR_Q2HR71

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

ATAACTCCACGC _A_Concatenation TCTATCACAACT _B

pos_ctrl_A

Target(s)

-1.568674958

0.73268364

-4.212893889

0.26956633

1.567091002

-4.236926482

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TOX4

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

vIRF2_VP64_pos_ctrl_X_mid

AATCGATCCTAC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.489945159

0.19343964

0.202873674

0.92643324

-0.171853256

-4.238368242

Human target

Virus_target

PRDM10

hvTR_Q2HR71

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

TACTTCTAGCGG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.771044327

0.00589775

1.802669461

0.40271471

0.227166966

0.998501722

-4.242732501

0.006225935

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094080.1_7

hvTR_Q2HR71

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

ACTTGATGGTTT _A_Concatenation ACAACGTGCATA _B

Target(s)

Target(s)

-0.692514716

0.04576547

-0.864133442

0.64850969

0.182135139

0.998501722

-4.244068346

0.018758746

Virus_target

Virus_target

hvTR_Q2HR73

hvTR_P10407

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

Mid_X_strong

AATCGATCCTAC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.179529056

0.1062238

-1.690226772

0.54837089

2.407313806

-4.248810284

Human target

neg_ctrl

PRDM10

Random_1

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TACATGAGGCAC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.110188313

4.25E-05

2.281086245

0.28160529

1.088317446

0.997690695

-4.303372063

0.065462272

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

LEUTX

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CATCTCACCTAG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.197025042

0.52243449

-2.182788257

0.07235545

0.660085508

0.997690695

-4.304705587

0.017149591

Virus_target

Virus_target

hvTR_P03206

hvTR_Q2HR71

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CCAGACGGTCTG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.171199216

0.93141616

-1.059009138

0.73516079

1.06733435

-4.307503416

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

LEUTX

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

CTACGTGGCCCC _A_Concatenation TATCGCAAGAAC _B

Target(s)

neg_ctrl

-0.543683368

0.45350915

-6.560404894

1.86E-05

-0.13555782

0.998501722

-4.311285817

0.057793972

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_5

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

Strong_X_random

AGAGTGCGCTCT _A_Concatenation AATCGATCCTAC _B

neg_ctrl

Target(s)

-0.064062926

0.94601266

-6.7713786

0.03611553

-0.111814107

-4.314207934

neg_ctrl

Human target

Random_1

PRDM10

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

Random_x_mid

GATGGAGCTACA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.03097096

0.2685694

4.900245925

2.074265421

0.856321281

-4.315742445

0.041678294

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03209

core_VP64_a

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

GTCACCCTCCTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.466800633

0.24013675

-6.020931608

9.74E-06

-0.206537113

0.998501722

-4.320134993

0.023467952

Human target

vIRF2_VP64_pos_ctrl

E2F5

core_VP64_a

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

TAAGATTCAACG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.048402176

0.95906455

-5.686562047

0.00025562

1.000422586

0.997690695

-4.32626098

0.020523923

Human target

neg_ctrl

ZNF292

Random_1

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CAACGCATGCCT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.628288976

0.70817197

4.47606778

6.127730728

-4.335994205

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

hvTR_Q2HR73

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

AGCCATAAACCT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.257278817

0.68024065

0.09908855

0.96438971

-0.359758648

0.997690695

-4.358553073

0.050540158

Virus_target

Virus_target

hvTR_P03209

hvTR_Q2HR73

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GCGAGGCAGACC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.360275424

0.32392216

-6.439546691

0.00062712

2.324548791

-4.358781485

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

LEUTX

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

GGTGTCTCGATT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.624188523

0.21779974

-4.069767293

0.00560113

0.716245491

0.997690695

-4.374873417

0.006225935

Human target

vIRF2_VP64_pos_ctrl

E2F5

core_VP64_a

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

TATCTATCGTGT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.730309581

0.67511461

-6.044735209

0.0180249

0.020872066

-4.382773153

Virus_target

Human target

hvTR_P03259

LEUTX

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

ACTTGATGGTTT _A_Concatenation ATCTCTCAGTTC _B

Target(s)

Target(s)

0.354565573

0.83094496

-6.292758405

9.06E-05

1.655966316

0.976975145

-4.401995538

0.07455661

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

mid_X_mid

ACTTGATGGTTT _A_Concatenation GCAGATTCGAAT _B

Target(s)

Target(s)

-0.503625638

0.03648591

2.403574915

0.22915921

0.224431312

0.998501722

-4.421684072

0.006225935

Virus_target

Human target

hvTR_Q2HR73

AK9

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

mid_X_mid

TCTGTACCAACG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.117258881

0.88561073

7.07722467

0.00648081

6.529618253

-4.431413231

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q6XA69

core_VP64_a

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

ACTTGATGGTTT _A_Concatenation CCCTGCCTCGGG _B

Target(s)

Target(s)

-0.790397321

0.3372476

-3.686964909

0.00950075

3.106307851

-4.433438099

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

mid_X_mid

AAGACCGGTGCC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.515793835

0.42503544

0.073904941

0.96782217

1.167830491

-4.436015135

Virus_target

Human target

hvTR_P08392

LEUTX

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation AGTTGCTTTGCT _B

neg_ctrl

neg_ctrl

-0.730028947

0.48317945

-4.093175689

0.00471042

-1.094140684

-4.439776185

neg_ctrl

neg_ctrl

Random_1

Random_2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

Random_x_random

AGAGTGCGCTCT _A_Concatenation AGTTAGGCTCTT _B

neg_ctrl

Target(s)

-0.439136018

0.09988704

2.220966371

0.33910718

1.207243507

0.997690695

-4.441176819

0.009395708

neg_ctrl

Human target

Random_1

TOX4

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

Random_x_mid

ATTGTATCTAAC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

0.127305933

0.91324404

-2.72751786

0.10406346

2.947022023

-4.443082246

Human target

neg_ctrl

SMARCB1

Random_1

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TAAAATTTATCA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.868226949

6.68E-05

-2.768624097

0.06080289

-0.011067718

-4.452910853

Human target

Human target

HSF1

LEUTX

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATTTGTAGACCG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.433474412

0.49285741

2.718416294

0.149883058

-4.457452304

Human target

Virus_target

MYCN

hvTR_Q2HR71

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATGTGGCACGAC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.098235848

0.93545833

-2.111269769

0.22915921

6.568806835

-4.472439525

Human target

Virus_target

ANKRD17

hvTR_Q2HR71

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

GAGATTGTGTCC _A_Concatenation CTGGTAGTTGTT _B

Target(s)

Target(s)

0.320980764

0.71346073

-5.050426907

0.00058527

-1.542496583

0.987041604

-4.479704305

0.059573762

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_F6KS47

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

Strong_x_unknown

AAGCAACGATAT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.88346018

0.04090853

-5.792604137

0.0030859

-4.026688107

-4.480472219

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

hvTR_Q2HR71

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

TTCTAATTTCCT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.540273244

0.78182953

-3.985362564

0.2155389

6.579502443

-4.483631681

Human target

Virus_target

WDR76

hvTR_Q2HR73

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ACTTGATGGTTT _A_Concatenation TATTAAAAGTGC _B

Target(s)

Target(s)

0.139393599

0.938493

2.006899938

0.24589402

3.957487218

-4.484349324

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_202

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

Mid_X_weak

ATAACTCCACGC _A_Concatenation AGGCTTCCCGCT _B

pos_ctrl_A

Target(s)

2.040915165

0.00211261

-6.668501501

5.91E-05

2.382234226

-4.484998981

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

vIRF2_VP64_pos_ctrl_X_mid

ATAACTCCACGC _A_Concatenation GATCGCATGTTC _B

pos_ctrl_A

Target(s)

0.082978051

0.9335834

-6.376605882

5.67E-05

-1.02920312

0.997690695

-4.526994085

0.049730741

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

INPP4A

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

VIRF2_VP64_pos strong_ctrl_x_strong

TCTTGGTTTTGA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.451300431

0.55517332

-4.689001206

0.02606586

2.076550966

-4.52740439

Human target

vIRF2_VP64_pos_ctrl

ZNF597

core_VP64_a

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CTCAGCGATATA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.624795577

0.48649146

-4.440579854

0.0042665

1.530626222

0.976975145

-4.544138798

0.031425518

Virus_target

Virus_target

hvTR_Q5Y0Q4

hvTR_Q2HR73

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATAACTCCACGC _A_Concatenation CATTGTTTAAAT _B

pos_ctrl_A

Target(s)

-0.004777326

0.99110789

4.326682043

0.13219999

2.290049946

-4.5449934

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

POLR1E

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

VIRF2_VP64_pos ctrl_x_unknown

GCAACGAGGGTC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.023332314

3.78E-11

-0.850362862

0.60710891

0.435178525

0.997690695

-4.56764221

0.003310148

Human target

Human target

QRICH2

LEUTX

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

TCTTAGAGGGTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.149560475

0.90029575

4.520447417

-1.029284335

-4.577139067

Human target

Virus_target

TRO

hvTR_Q2HR73

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ATAACTCCACGC _A_Concatenation ACTCGTGTTGTC _B

pos_ctrl_A

Target(s)

0.296043249

0.72790325

-1.761697233

0.49541295

2.508671595

-4.610891336

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q9QB97

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

vIRF2_VP64_pos_ctrl_X_mid

ACTTGATGGTTT _A_Concatenation ATTGTATCTAAC _B

Target(s)

Target(s)

-0.018695922

0.95135448

-2.643588952

0.08137967

0.026529149

0.998980766

-4.611490935

0.006225935

Virus_target

Human target

hvTR_Q2HR73

SMARCB1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

mid_X_mid

GAGATTGTGTCC _A_Concatenation Joint_ 2_B

Target(s)

neg_ctrl

-0.197893967

0.92359363

1.453565367

0.52277462

3.107333606

-4.634189797

Virus_target

neg_ctrl

hvTR_Q2HR71

Joint_2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

Strong-X-joint

ACAACGTGCATA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.060447182

0.93881926

-4.573919945

0.00909169

-4.900126016

-4.664300495

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P10407

core_VP64_a

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AAGACCGGTGCC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.591159752

0.001233

5.218320955

0.00297318

-0.574921152

0.997690695

-4.67892565

0.044862171

Virus_target

Virus_target

hvTR_P08392

hvTR_Q2HR71

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ACCAGTATTTAA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.132991384

0.93141616

-4.958182575

0.00228119

1.487683456

0.995270541

-4.682025328

0.054917192

Human target

Virus_target

ARNTL2

hvTR_Q2HR71

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CATTGTTTAAAT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.042359123

0.96035322

4.074295196

0.04515966

1.567252447

0.983636094

-4.695642793

Human target

Virus_target

POLR1E

hvTR_Q2HR73

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Unknown_X_mid

GAGATTGTGTCC _A_Concatenation AGTTAGGCTCTT _B

Target(s)

Target(s)

0.936025174

0.00341741

-3.936354906

0.00579804

0.671114606

-4.696133418

Virus_target

Human target

hvTR_Q2HR71

TOX4

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

Strong_X_mid

AGAGTGCGCTCT _A_Concatenation GATCGCATGTTC _B

neg_ctrl

Target(s)

-0.015836742

0.9854934

-6.107048064

0.0038283

-0.116480357

0.998501722

-4.696930001

0.035570865

neg_ctrl

Human target

Random_1

INPP4A

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

Random_x_strong

GAGATTGTGTCC _A_Concatenation ACCAGTATTTAA _B

Target(s)

Target(s)

0.617764052

0.51346664

-3.734336377

0.03818366

0.048940146

-4.701853986

Virus_target

Human target

hvTR_Q2HR71

ARNTL2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Strong_X_strong

Stop 2_A splice GAGATTGTGTCC B

neg_ctrl

Target(s)

-1.006526263

0.06075194

-1.855058029

0.25363982

0.240419385

-4.709227495

neg_ctrl

Virus_target

Stop_2

hvTR_Q2HR71

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Termination_X_strong

ATGACCCCTTGT _A_Concatenation AGTTAGGCTCTT _B

Target(s)

Target(s)

3.009551364

1.30E-05

0.669192288

0.76446307

3.013928466

-4.724606407

Human target

Human target

LEUTX

TOX4

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

Strong_X_mid

GTTCCACGCCTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.17213267

0.38922543

0.491500432

0.82062053

4.134002823

0.412917083

-4.731036848

Human target

Virus_target

ZFX

hvTR_Q2HR71

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

TACATGAGGCAC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.075683209

0.93141616

-3.359850802

0.05968663

3.581867401

-4.733546803

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

hvTR_Q2HR71

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CATTGTTTAAAT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.61670292

0.02838239

5.120394901

0.00542747

-0.065469769

0.998501722

-4.750851108

0.007269653

Human target

Human target

POLR1E

LEUTX

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Unknown_X_strong

ATAACTCCACGC _A_Concatenation CTGCCGGTTGCG _B

pos_ctrl_A

Target(s)

-0.974189351

0.00589775

-0.846696447

0.62805366

0.589387686

0.997690695

-4.752187921

0.002219785

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

vIRF2_VP64_pos_ctrl_X_mid

CATTAGTCCCGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.056339111

0.93141616

-3.614817111

0.00212573

-0.050134546

0.998501722

-4.753277601

0.035451075

Virus_target

Virus_target

hvTR_P06930

hvTR_Q2HR73

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

ACGACTCACCGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.193313147

0.88133884

-5.590261485

0.0957563

2.226551152

-4.768538394

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

hvTR_Q2HR71

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

AGGCTTCCCGCT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-1.246599141

0.04064654

-5.850706836

0.02716395

1.051683032

-4.773700255

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

hvTR_Q2HR73

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TATCTATCGTGT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.24186904

0.3372476

-5.104786204

0.03676994

6.879812674

-4.797054281

Virus_target

neg_ctrl

hvTR_P03259

Random_1

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

ATAACTCCACGC _A_Concatenation Joint_ 2_B

pos_ctrl_A

neg_ctrl

0.423245033

0.82196175

-6.925253057

0.00881075

6.908812568

-4.827240333

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Joint_2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

VIRF2_VP64_pos ctrl X joint

GAGATTGTGTCC _A_Concatenation TATTAAAAGTGC _B

Target(s)

Target(s)

1.323637823

1.86E-05

5.919891448

1.10E-14

0.486571997

0.997690695

-4.841618153

0.049877065

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_202

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

Strong_x_weak

ACTTGATGGTTT _A_Concatenation CCCCTTAGGAAT _B

Target(s)

Target(s)

-0.074659428

0.93141616

-4.597888157

0.00062712

0.045908153

0.998501722

-4.858585044

0.031298274

Virus_target

Human target

hvTR_Q2HR73

SYNE1

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

mid_X_mid

CTACGTGGCCCC _A_Concatenation CCCGTAGGGGCT _B

Target(s)

Target(s)

-0.818709091

0.12732726

-6.521214944

0.00113924

0.586946859

-4.901511591

Virus_target

Human target

hvTR_Q2HR71

TET3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

Strong_X_strong

CTCGCACCGAGG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.596136237

0.00048803

-5.22495664

0.00156378

1.86474922

0.95807515

-4.952515892

0.050540158

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

Random_1

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

GGTGTCTCGATT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.71708475

0.37850503

-5.956180795

0.00109079

-0.285349999

-4.959200203

Human target

Virus_target

E2F5

hvTR_Q2HR71

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Strong_X_strong

CTCAGCGATATA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.063821297

0.89491762

-5.738623465

3.70E-05

0.475790468

0.997690695

-4.96663111

0.001244361

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q5Y0Q4

core_VP64_a

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

EPICXV.47-A\u splice_ ACTTGATGGTTT _b

pos_ctrl_A

Target(s)

-0.402908865

0.76232875

-2.710973367

0.20622537

3.259352174

-4.987920795

vIRF2_VP64_pos_ctrl

Virus_target

3x_vIRF2_core

hvTR_Q2HR73

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

vIRF2_VP64_pos_ctrl_X_mid

CTACGTGGCCCC _A_Concatenation CCCTATGTTCTA _B

Target(s)

pos_ctrl_A

0.485138676

0.29695525

1.93677332

0.36067721

1.360890619

0.997690695

-4.994725112

0.044797652

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

core_VP64_b

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation TCAGCCGTAGGC _B

neg_ctrl

Target(s)

0.712239358

0.09988704

1.994360846

0.61718307

0.997690695

-5.001859257

0.044930268

neg_ctrl

Virus_target

Random_1

hvTR_Q805Y1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

Random_x_mid

ACGGCGTAAGTA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.440957901

0.75770773

-5.267406288

0.00062712

1.151328375

0.997690695

-5.057401522

0.049877065

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094078.1_5

hvTR_Q2HR73

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TCAGCCGTAGGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

0.391192155

0.69733379

-3.579724517

0.06553086

0.547437872

-5.058243009

Virus_target

Virus_target

hvTR_Q805Y1

hvTR_Q2HR71

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CATCTCACCTAG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.351939043

0.52901596

0.222124096

0.91035624

0.062090878

-5.09443553

Virus_target

Human target

hvTR_P03206

LEUTX

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

ATTTGTAGACCG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.656975642

0.4482293

-3.271410603

0.01939364

3.06121137

0.665412691

-5.101365259

0.086227003

Human target

vIRF2_VP64_pos_ctrl

MYCN

core_VP64_a

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation CCCTATGTTCTA _B

Target(s)

pos_ctrl_A

0.840486421

0.34471177

-2.192609225

0.31960259

-3.620552389

-5.103522048

Human target

vIRF2_VP64_pos_ctrl

LEUTX

core_VP64_b

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TCTTGGTTTTGA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.76021617

0.37525592

-4.690895046

0.04158147

0.193477589

-5.123854273

Human target

Virus_target

ZNF597

hvTR_Q2HR71

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GGCACAGCTCCA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.382298774

0.19431573

-5.846903452

0.00989082

1.741784317

-5.161491347

Human target

neg_ctrl

DTX2

Random_1

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Unknown_X_random

TAAGATTCAACG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.568125793

0.36878074

-2.892171441

0.08285043

2.427193341

-5.173101919

Human target

Virus_target

ZNF292

hvTR_Q2HR73

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CCCTGCCTCGGG _B

Target(s)

Target(s)

-1.487579562

0.07185248

-3.197615954

0.05166799

-3.398202267

-5.180846526

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

Strong_X_mid

TTTAACGGATTG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.018838252

0.570298

-3.127128404

-0.965608977

-5.195299598

Human target

Virus_target

TWIST2

hvTR_Q2HR71

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GAGACAGCTCTC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.887538375

0.3372476

4.745789853

-0.916888787

-5.205950127

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

Random_1

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ACTTGATGGTTT _A_Concatenation AAAACAAGCATT _B

Target(s)

Target(s)

1.191964895

0.02320276

-1.060619257

1.306681057

-5.223605812

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_030656.1_cds_YP_009268803.1_88

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

Mid_X_weak

ACTTGATGGTTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.131125839

0.94239857

-5.647380666

0.00791621

1.443241929

-5.239741979

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR73

core_VP64_a

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation CAACGCATGCCT _B

Target(s)

Target(s)

-0.512214239

0.71346073

-1.803269258

0.48762892

3.836164752

-5.277961857

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

Strong_x_weak

CTCGTTATGGCA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-0.071037944

0.9335834

-0.826197308

0.56137619

2.699232299

-5.30571031

Human target

Virus_target

NOVA1

hvTR_Q2HR71

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation ATAACTCCACGC _B

neg_ctrl

pos_ctrl_A

0.330164685

0.81666774

-4.056944834

0.03478224

0.572663702

-5.363605979

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_1

core_VP64_a

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Random_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation AAGCAACGATAT _B

neg_ctrl

Target(s)

-2.175492411

0.44779842

-0.958233703

0.70352371

7.455397967

-5.393917529

neg_ctrl

Virus_target

Random_1

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

Random_x_mid

ATGACCCCTTGT _A_Concatenation CCCCTTAGGAAT _B

Target(s)

Target(s)

-0.556667594

0.49783248

-2.321875682

0.16019145

-2.928002943

-5.455261016

Human target

Human target

LEUTX

SYNE1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

Strong_X_mid

CTGGTAGTTGTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.083074874

0.89748071

-1.23687068

0.50023889

0.358149991

0.998501722

-5.491915626

0.026617437

Virus_target

Virus_target

hvTR_F6KS47

hvTR_Q2HR71

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

CCGCCCTTATGT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.060129109

0.24458972

3.402400654

1.879885692

-5.50025502

Human target

Virus_target

ZFX

hvTR_Q2HR71

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ACTTGATGGTTT _A_Concatenation GAGACAGCTCTC _B

Target(s)

Target(s)

-0.209734714

0.75467612

-0.270868577

0.89582846

4.581660478

-5.507927576

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

mid_X_mid

GAGATTGTGTCC _A_Concatenation GGCACTGTCGAG _B

Target(s)

Target(s)

-2.12334167

3.21E-05

-4.702557832

0.01719167

-1.602540214

-5.599821069

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P17147

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

Strong_x_unknown

GGGAGTATGTCG _A_Concatenation ATAACTCCACGC _B

neg_ctrl

pos_ctrl_A

-2.208814368

0.16187644

-3.776665452

0.14747479

2.960548103

-5.616940031

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_4

core_VP64_a

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Random_X_vIRF2\u VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation TACTTCTAGCGG _B

Target(s)

Target(s)

-0.141022638

0.92647166

-7.160911356

0.00057613

-0.125933095

-5.625285367

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094080.1_7

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

Strong_x_weak

AGAGTGCGCTCT _A_Concatenation AAACTTTGAGCG _B

neg_ctrl

Target(s)

-0.340808887

0.62528738

-4.895000121

0.0363895

0.546714267

0.997690695

-5.656190678

0.023621511

neg_ctrl

Human target

Random_1

ATF6B

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

Random_x_strong

AGAGTGCGCTCT _A_Concatenation Stop_1_B

neg_ctrl

neg_ctrl

-1.224087981

0.48857008

-0.753723052

0.73513388

7.712048094

-5.658725253

neg_ctrl

neg_ctrl

Random_1

Stop_1

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

Random_x_termination

CTCCATTAATGA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

5.404503701

0.00589775

-5.877830928

0.02663924

1.119790989

-5.681347684

Virus_target

neg_ctrl

hvTR_Q5IXR3

Random_1

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

AGCCATAAACCT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.735122894

0.22884458

2.995358338

0.24589402

0.344876681

-5.68630643

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03209

core_VP64_a

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CTACGTGGCCCC _A_Concatenation GGCACTGTCGAG _B

Target(s)

Target(s)

-0.308396943

0.47815206

-6.137944266

0.00109019

-1.156379204

-5.727758564

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P17147

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

Strong_x_unknown

AGAGTGCGCTCT _A_Concatenation GATGGAGCTACA _B

neg_ctrl

Target(s)

-1.33621996

0.02664091

-2.391722128

0.18668384

1.152177441

0.997690695

-5.782618445

0.015867719

neg_ctrl

Virus_target

Random_1

hvTR_P03209

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Random_x_strong

TACTTCTAGCGG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.189787144

0.04628107

5.829358188

0.03155841

1.545703361

-5.831396042

Virus_target

neg_ctrl

cds_NC_025350.1_cds_YP_009094080.1_7

Random_1

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

GTTCCACGCCTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.769981604

0.86342423

-2.886813019

0.18770774

1.994466765

-5.840797432

Human target

neg_ctrl

ZFX

Random_1

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AATCGAGACCAG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-2.347860519

1.46E-14

-5.215253713

0.00075558

2.168129085

0.913394463

-5.842093368

0.038629478

Virus_target

Virus_target

hvTR_Q8BB47

hvTR_Q2HR73

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Strong_X_mid

CTCGTTATGGCA _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.494353708

0.62724977

-3.236670463

0.0084926

1.91307286

-5.871878995

Human target

Virus_target

NOVA1

hvTR_Q2HR73

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CTACGTGGCCCC _A_Concatenation CTCCATTAATGA _B

Target(s)

Target(s)

1.179654668

0.17168108

4.358595417

0.09769005

0.116110257

-5.884099132

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q5IXR3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

Strong_x_weak

ATAACTCCACGC _A_Concatenation AATCGATCCTAC _B

pos_ctrl_A

Target(s)

0.153725912

0.91324404

-4.870495372

0.0030859

-0.461338496

-5.895507635

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

PRDM10

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

vIRF2_VP64_pos_ctrl_X_mid

ATAACTCCACGC _A_Concatenation ATGACCCCTTGT _B

pos_ctrl_A

Target(s)

-0.424943429

0.44779842

-1.280595371

0.44159106

0.805067743

-5.943417085

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

LEUTX

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation AAGGGTAAATTG _B

pos_ctrl_A

Target(s)

-0.769843751

0.05287662

-4.288035434

0.00046299

0.084207744

-5.958619092

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q69513

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

vIRF2_VP64_pos_ctrl_X_mid

GGAGGCACATCG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.615425531

0.39800543

6.868327583

0.577456831

-5.997110012

Virus_target

Virus_target

hvTR_Q87042

hvTR_Q2HR71

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GACTGTGGGCGG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-3.698113905

0.00599572

-5.194429706

0.00063386

0.901901075

-5.999739644

Human target

Virus_target

MON2

hvTR_Q2HR71

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

TCTTGGTTTTGA _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

2.589077657

0.0005918

-5.088682444

0.00382558

-1.109166747

-6.005234499

Human target

neg_ctrl

ZNF597

Random_1

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AAGACCGGTGCC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-0.522591911

0.59725044

-4.104785351

0.06099515

2.660729441

0.812553322

-6.025279443

0.040091246

Virus_target

neg_ctrl

hvTR_P08392

Random_1

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ACTTTAGTAACA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.226775341

0.80528278

-0.288717664

0.8725678

1.612048606

-6.12645012

Virus_target

Virus_target

hvTR_Q69113

hvTR_Q2HR71

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CATTGTTTAAAT _B

Target(s)

Target(s)

-2.265185586

0.00014167

-5.983440255

0.00141375

-1.604256553

0.997690695

-6.152999877

Virus_target

Human target

hvTR_Q2HR71

POLR1E

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

Strong_x_unknown

CTACGTGGCCCC _A_Concatenation AAAACAAGCATT _B

Target(s)

Target(s)

-0.493048929

0.86342423

-43.28085123

-0.457230807

0.997690695

-6.162906773

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_030656.1_cds_YP_009268803.1_88

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

Strong_x_weak

CTCGCACCGAGG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.76552309

0.21159296

-5.643704007

0.0252298

1.063802185

0.997690695

-6.186463038

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

hvTR_Q2HR71

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CTACGTGGCCCC _A_Concatenation TATTAAAAGTGC _B

Target(s)

Target(s)

-0.07415744

0.93141616

-4.198302004

0.00604998

1.733461308

0.995270541

-6.229205387

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_202

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

Strong_x_weak

CATCTCACCTAG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.4416704

0.32544126

-2.041886392

0.24776135

1.012415533

0.997690695

-6.270797064

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03206

core_VP64_a

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

AGTTGCTTTGCT _A_Concatenation ATGACCCCTTGT _B

neg_ctrl

Target(s)

0.301355238

0.62528738

-2.534783802

0.11387209

1.866959184

0.983636094

-6.38164972

0.095807415

neg_ctrl

Human target

Random_2

LEUTX

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Random_x_strong

ATAACTCCACGC _A_Concatenation GTACATACCGAA _B

pos_ctrl_A

Target(s)

-1.171288747

0.67964161

-3.153192584

0.07956968

2.451510292

0.913394463

-6.516748909

0.097929575

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

vIRF2_VP64_pos_ctrl_X_mid

ATTTGTAGACCG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.366475595

0.73379786

-4.811401615

0.01033665

0.495767171

0.997690695

-6.640794238

0.067705317

Human target

Human target

MYCN

LEUTX

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AGAGTGCGCTCT _A_Concatenation AATGGCACTAGC _B

neg_ctrl

Target(s)

-0.623623953

0.52540625

-1.157186972

0.50023889

2.196145729

0.95807515

-6.686152164

0.085225681

neg_ctrl

Virus_target

Random_1

cds_NC_024711.1_cds_YP_009052522.2_44

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

Random_x_weak

CTACGTGGCCCC _A_Concatenation CGCCGGCATACA _B

Target(s)

Target(s)

-0.946148243

0.01727004

2.99290184

0.23526565

-0.059486678

0.998501722

-6.747982296

0.062504997

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_030656.1_cds_YP_009268729.1_14

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

Strong_X_strong

CTCAGCGATATA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

1.748245318

6.77E-14

1.721792601

0.948350533

0.997690695

-6.749330014

0.067193726

Virus_target

Human target

hvTR_Q5Y0Q4

LEUTX

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

TACTTCTAGCGG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.363812452

0.26992692

4.232834683

0.06073326

1.276260349

0.997690695

-6.806346096

0.068273719

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094080.1_7

hvTR_Q2HR73

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

ACTTGATGGTTT _A_Concatenation AGGCTTCCCGCT _B

Target(s)

Target(s)

-0.027710303

0.96724179

-4.83793617

0.01741316

-0.825336777

0.997690695

-6.863460269

0.062240466

Virus_target

Virus_target

hvTR_Q2HR73

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

mid_X_mid

AAACTTTGAGCG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.549842464

0.42955596

-5.729682993

0.00087405

1.155328609

0.997690695

-7.011659883

0.059746019

Human target

vIRF2_VP64_pos_ctrl

ATF6B

core_VP64_a

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

AAGCAACGATAT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

7.944976712

7.585911696

0.02127152

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

Random_1

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AAGCAACGATAT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.664710356

0.59461055

-4.348682237

0.16881711

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

core_VP64_a

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

AAGCAACGATAT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.309483322

0.95787851

-1.478927037

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

LEUTX

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

AAGCAACGATAT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-2.346593436

0.53232005

2.361801184

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

hvTR_Q2HR71

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

AAGGGTAAATTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.617316133

1.391426822

0.67033502

Virus_target

neg_ctrl

hvTR_Q69513

Random_1

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AAGGGTAAATTG _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.50744682

0.67511461

0.213570338

0.94993175

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q69513

core_VP64_a

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACGACTCACCGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-0.585300332

0.91102312

3.314306961

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

hvTR_Q2HR73

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ACGACTCACCGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.061283242

0.71346073

-16.01374614

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

Random_1

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

ACGGCGTAAGTA _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.646268355

0.87986969

3.238855078

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094078.1_5

core_VP64_a

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACGGCGTAAGTA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.568603773

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094078.1_5

hvTR_Q2HR71

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ACGGCGTAAGTA _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

3.09768615

3.238855078

Virus_target

Virus_target

cds_NC_025350.1_cds_YP_009094078.1_5

hvTR_Q2HR71

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ACTCGTGTTGTC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.21059429

0.86342423

5.52800102

0.03526053

Virus_target

Virus_target

hvTR_Q9QB97

hvTR_Q2HR73

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ACTCGTGTTGTC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.380605892

3.182352799

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q9QB97

core_VP64_a

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

ACTCGTGTTGTC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.08639898

4.511437744

0.14019482

Virus_target

Virus_target

hvTR_Q9QB97

hvTR_Q2HR71

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

ACTTGATGGTTT _A_Concatenation AAACTTTGAGCG _B

Target(s)

Target(s)

0.635247668

0.91324404

-0.120838354

0.96917964

Virus_target

Human target

hvTR_Q2HR73

ATF6B

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

Mid_X_strong

ACTTGATGGTTT _A_Concatenation ACGGCGTAAGTA _B

Target(s)

Target(s)

-0.355250833

0.95038187

3.88115205

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_025350.1_cds_YP_009094078.1_5

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

mid_X_mid

ACTTGATGGTTT _A_Concatenation ATCCAATCTGTG _B

Target(s)

Target(s)

-2.274709102

0.03561302

Virus_target

Human target

hvTR_Q2HR73

GLI2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

mid_X_mid

ACTTGATGGTTT _A_Concatenation CCCGTAGGGGCT _B

Target(s)

Target(s)

-1.68102392

0.8027561

-2.22903373

Virus_target

Human target

hvTR_Q2HR73

TET3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

Mid_X_strong

ACTTGATGGTTT _A_Concatenation CCTAAATGCAAG _B

Target(s)

Target(s)

-0.345572905

0.93767673

4.074562184

0.22666043

Virus_target

Virus_target

hvTR_Q2HR73

cds_NC_025410.1_cds_YP_009094498.1_7

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

mid_X_mid

ACTTGATGGTTT _A_Concatenation GGCCTTTCGGGC _B

Target(s)

neg_ctrl

Virus_target

neg_ctrl

hvTR_Q2HR73

Random_3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

Mid_X_random

ACTTGATGGTTT _A_Concatenation GTCACCCTCCTT _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR73

E2F5

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

mid_X_mid

ACTTGATGGTTT _A_Concatenation Stop_2_B

Target(s)

neg_ctrl

-1.424116901

0.40068284

-5.059430759

0.13874298

Virus_target

neg_ctrl

hvTR_Q2HR73

Stop_2

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

Mid_X_termination

ACTTGATGGTTT _A_Concatenation TCTATCACAACT _B

Target(s)

Target(s)

-6.09199378

-5.135016247

Virus_target

Human target

hvTR_Q2HR73

TOX4

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

mid_X_mid

ACTTGATGGTTT _A_Concatenation TTAGTGCCATAC _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR73

TET3

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

mid_X_mid

AGAGTGCGCTCT _A_Concatenation ACGGCGTAAGTA _B

neg_ctrl

Target(s)

3.28719166

0.58023965

neg_ctrl

Virus_target

Random_1

cds_NC_025350.1_cds_YP_009094078.1_5

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

Random_x_mid

AGAGTGCGCTCT _A_Concatenation ATCCAATCTGTG _B

neg_ctrl

Target(s)

1.733168452

0.752551

3.170857119

neg_ctrl

Human target

Random_1

GLI2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

Random_x_mid

AGAGTGCGCTCT _A_Concatenation CATCTGAGTCGT _B

neg_ctrl

pos_ctrl_A

0.166025685

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_1

RWY_VP16_vIRF2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

Random_X_vIRF2\u VP64_pos_ctrl

AGAGTGCGCTCT _A_Concatenation CCCGTAGGGGCT _B

neg_ctrl

Target(s)

-0.962615391

neg_ctrl

Human target

Random_1

TET3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

Random_x_strong

AGAGTGCGCTCT _A_Concatenation CCTAAATGCAAG _B

neg_ctrl

Target(s)

0.950595768

0.89056441

4.511448967

0.14019482

neg_ctrl

Virus_target

Random_1

cds_NC_025410.1_cds_YP_009094498.1_7

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

Random_x_mid

AGAGTGCGCTCT _A_Concatenation CTACGTGGCCCC _B

neg_ctrl

Target(s)

5.229533761

0.15190336

neg_ctrl

Virus_target

Random_1

hvTR_Q2HR71

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Random_x_strong

AGAGTGCGCTCT _A_Concatenation GGCCTTTCGGGC _B

neg_ctrl

neg_ctrl

neg_ctrl

neg_ctrl

Random_1

Random_3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

Random_x_random

AGAGTGCGCTCT _A_Concatenation GGGAGTATGTCG _B

neg_ctrl

neg_ctrl

0.967797242

0.11077416

-4.51458373

0.10777474

neg_ctrl

neg_ctrl

Random_1

Random_4

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

Random_x_random

AGAGTGCGCTCT _A_Concatenation GGTGTCTCGATT _B

neg_ctrl

Target(s)

0.047609976

0.99110789

3.88115205

neg_ctrl

Human target

Random_1

E2F5

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

Random_x_strong

AGAGTGCGCTCT _A_Concatenation GTCACCCTCCTT _B

neg_ctrl

Target(s)

neg_ctrl

Human target

Random_1

E2F5

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

Random_x_mid

AGAGTGCGCTCT _A_Concatenation Stop_2_B

neg_ctrl

neg_ctrl

3.072851399

0.24424642

neg_ctrl

neg_ctrl

Random_1

Stop_2

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

Random_x_termination

AGAGTGCGCTCT _A_Concatenation TACTTCTAGCGG _B

neg_ctrl

Target(s)

-7.853662346

0.0065342

3.320391013

0.27528996

neg_ctrl

Virus_target

Random_1

cds_NC_025350.1_cds_YP_009094080.1_7

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

Random_x_weak

AGAGTGCGCTCT _A_Concatenation TCTATCACAACT _B

neg_ctrl

Target(s)

neg_ctrl

Human target

Random_1

TOX4

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

Random_x_mid

AGAGTGCGCTCT _A_Concatenation TTAGTGCCATAC _B

neg_ctrl

Target(s)

neg_ctrl

Human target

Random_1

TET3

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

Random_x_mid

AGCCAGGTCACC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-6.366830417

2.868800308

0.15019428

Human target

neg_ctrl

MESP1

Random_1

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

AGCCAGGTCACC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-3.474457124

0.47868657

2.37307374

0.14562931

Human target

Human target

MESP1

LEUTX

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Strong_X_strong

AGGCTTCCCGCT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.289944801

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

Random_1

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

AGGCTTCCCGCT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.115550616

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

hvTR_Q2HR71

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

AGGCTTCCCGCT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.823085941

0.78251797

3.238855078

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

hvTR_Q2HR71

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

ATAACTCCACGC _A_Concatenation AGCCAGGTCACC _B

pos_ctrl_A

Target(s)

3.046493862

0.57362051

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

MESP1

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation CCCGTAGGGGCT _B

pos_ctrl_A

Target(s)

-1.156993199

0.73105591

4.058761015

0.17610913

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TET3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation CTACGTGGCCCC _B

pos_ctrl_A

Target(s)

1.289944801

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_a

hvTR_Q2HR71

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation GACTGTGGGCGG _B

pos_ctrl_A

Target(s)

3.80171056

0.18222191

3.880482673

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

MON2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation GGCCTTTCGGGC _B

pos_ctrl_A

neg_ctrl

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Random_3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

VIRF2_VP64_pos ctrl_x_random

ATAACTCCACGC _A_Concatenation GGTGTCTCGATT _B

pos_ctrl_A

Target(s)

-0.27806378

0.9335834

2.406570592

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

E2F5

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

VIRF2_VP64_pos strong_ctrl_x_strong

ATAACTCCACGC _A_Concatenation GTCACCCTCCTT _B

pos_ctrl_A

Target(s)

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

E2F5

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

vIRF2_VP64_pos_ctrl_X_mid

ATAACTCCACGC _A_Concatenation Stop_2_B

pos_ctrl_A

neg_ctrl

-8.17897764

3.238855078

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_a

Stop_2

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

VIRF2_VP64_pos ctrl X termination

ATAACTCCACGC _A_Concatenation TTAGTGCCATAC _B

pos_ctrl_A

Target(s)

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

TET3

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

vIRF2_VP64_pos_ctrl_X_mid

ATAACTCCACGC _A_Concatenation TTCTAATTTCCT _B

pos_ctrl_A

Target(s)

-0.485384513

0.87986969

2.802166251

0.22513253

vIRF2_VP64_pos_ctrl

Human target

core_VP64_a

WDR76

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

VIRF2_VP64_pos strong_ctrl_x_strong

ATCCAATCTGTG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

1.129263174

0.4610642

0.192620333

0.94571421

Human target

Virus_target

GLI2

hvTR_Q2HR73

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

ATGACCCCTTGT _A_Concatenation AAAACAAGCATT _B

Target(s)

Target(s)

3.124427211

0.5677544

Human target

Virus_target

LEUTX

cds_NC_030656.1_cds_YP_009268803.1_88

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

Strong_x_weak

ATGACCCCTTGT _A_Concatenation AAACTTTGAGCG _B

Target(s)

Target(s)

-0.152739419

3.182352799

Human target

Human target

LEUTX

ATF6B

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

Strong_X_strong

ATGACCCCTTGT _A_Concatenation AGCCAGGTCACC _B

Target(s)

Target(s)

0.360100154

5.977289987

0.02707288

Human target

Human target

LEUTX

MESP1

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

Strong_X_strong

ATGACCCCTTGT _A_Concatenation AGGCTTCCCGCT _B

Target(s)

Target(s)

-4.698834126

0.33149001

-4.353885607

0.11677552

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

Strong_X_mid

ATGACCCCTTGT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.795557194

Human target

vIRF2_VP64_pos_ctrl

LEUTX

core_VP64_a

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation ATCCAATCTGTG _B

Target(s)

Target(s)

-1.103048635

0.86892322

Human target

Human target

LEUTX

GLI2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

Strong_X_mid

ATGACCCCTTGT _A_Concatenation ATCTCTCAGTTC _B

Target(s)

Target(s)

1.346083555

0.62528738

-43.28085123

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

Strong_X_mid

ATGACCCCTTGT _A_Concatenation CATCTGAGTCGT _B

Target(s)

pos_ctrl_A

-3.023585795

0.570298

-0.945884629

0.76087181

Human target

vIRF2_VP64_pos_ctrl

LEUTX

RWY_VP16_vIRF2

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

Strong_X_vIRF2\u VP64_pos_ctrl

ATGACCCCTTGT _A_Concatenation CCCGTAGGGGCT _B

Target(s)

Target(s)

3.040916671

Human target

Human target

LEUTX

TET3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

Strong_X_strong

ATGACCCCTTGT _A_Concatenation CCGCCCTTATGT _B

Target(s)

Target(s)

0.077749843

0.98703959

7.94102658

0.00337399

Human target

Human target

LEUTX

ZFX

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

Strong_X_mid

ATGACCCCTTGT _A_Concatenation CCTAAATGCAAG _B

Target(s)

Target(s)

2.610465196

0.28726554

3.880482673

Human target

Virus_target

LEUTX

cds_NC_025410.1_cds_YP_009094498.1_7

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

Strong_X_mid

ATGACCCCTTGT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

Human target

Virus_target

LEUTX

hvTR_Q2HR71

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

ATGACCCCTTGT _A_Concatenation GAGACAGCTCTC _B

Target(s)

Target(s)

4.475910609

Human target

Virus_target

LEUTX

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

Strong_X_mid

ATGACCCCTTGT _A_Concatenation GGCACTGTCGAG _B

Target(s)

Target(s)

-3.603196445

1.025530185

0.72115884

Human target

Virus_target

LEUTX

hvTR_P17147

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

Strong_x_unknown

ATGACCCCTTGT _A_Concatenation GGCCTTTCGGGC _B

Target(s)

neg_ctrl

Human target

neg_ctrl

LEUTX

Random_3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

Strong_X_random

ATGACCCCTTGT _A_Concatenation GGTGTCTCGATT _B

Target(s)

Target(s)

-3.075478141

2.810937394

Human target

Human target

LEUTX

E2F5

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

Strong_X_strong

ATGACCCCTTGT _A_Concatenation GTCACCCTCCTT _B

Target(s)

Target(s)

Human target

Human target

LEUTX

E2F5

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

Strong_X_mid

ATGACCCCTTGT _A_Concatenation TCTATCACAACT _B

Target(s)

Target(s)

3.880482673

Human target

Human target

LEUTX

TOX4

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

Strong_X_mid

ATGACCCCTTGT _A_Concatenation TTAGTGCCATAC _B

Target(s)

Target(s)

Human target

Human target

LEUTX

TET3

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

Strong_X_mid

CATGCTAACACC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-7.336940953

5.402315006

0.00370107

Virus_target

neg_ctrl

hvTR_F5HCV3

Random_1

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Strong_X_random

CCAGACGGTCTG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

1.108875481

0.76651497

-1.484006877

0.60245729

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

Random_1

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Weak_X_random

CCCCTTAGGAAT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

0.078423388

0.96692351

-3.939831584

0.21401893

Human target

Human target

SYNE1

LEUTX

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CCCCTTAGGAAT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-1.524525408

0.12502988

-3.929579096

0.1287179

Human target

Virus_target

SYNE1

hvTR_Q2HR71

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CCCGTAGGGGCT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

3.273902741

0.34507859

-4.56873309

0.17686603

Human target

vIRF2_VP64_pos_ctrl

TET3

core_VP64_a

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Strong_X_vIRF2\u VP64_pos_ctrl

CCGCCCTTATGT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

0.189224022

0.95448989

0.954544663

0.72115884

Human target

vIRF2_VP64_pos_ctrl

ZFX

core_VP64_a

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CCTAAATGCAAG _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

-6.206799848

0.19361934

2.704493055

Virus_target

Virus_target

cds_NC_025410.1_cds_YP_009094498.1_7

hvTR_Q2HR73

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CCTAAATGCAAG _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

-1.50970093

3.243191603

Virus_target

neg_ctrl

cds_NC_025410.1_cds_YP_009094498.1_7

Random_1

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CCTAAATGCAAG _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-0.152739419

Virus_target

Human target

cds_NC_025410.1_cds_YP_009094498.1_7

LEUTX

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CCTAAATGCAAG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-4.986651789

0.21173203

3.170857119

Virus_target

Virus_target

cds_NC_025410.1_cds_YP_009094498.1_7

hvTR_Q2HR71

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CCTAAATGCAAG _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

3.88115205

Virus_target

Virus_target

cds_NC_025410.1_cds_YP_009094498.1_7

hvTR_Q2HR71

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CGATGGCGGAAT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

3.870749594

3.880482673

Human target

Virus_target

KIAA1586

hvTR_Q2HR73

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

CGATGGCGGAAT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-0.152739419

Human target

vIRF2_VP64_pos_ctrl

KIAA1586

core_VP64_a

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

CGATGGCGGAAT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.197295569

3.880482673

Human target

Human target

KIAA1586

LEUTX

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

CGATGGCGGAAT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

1.96454545

Human target

Virus_target

KIAA1586

hvTR_Q2HR71

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

CGATGGCGGAAT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.737842502

Human target

Virus_target

KIAA1586

hvTR_Q2HR71

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Weak_X_Strong

CGGCAATTGCTT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

Virus_target

Virus_target

hvTR_Q9QB93

hvTR_Q2HR73

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

CGGCAATTGCTT _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

Virus_target

neg_ctrl

hvTR_Q9QB93

Random_1

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

CGGCAATTGCTT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q9QB93

core_VP64_a

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

CGGCAATTGCTT _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q9QB93

LEUTX

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

CGGCAATTGCTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

Virus_target

Virus_target

hvTR_Q9QB93

hvTR_Q2HR71

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

CGGCAATTGCTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

Virus_target

Virus_target

hvTR_Q9QB93

hvTR_Q2HR71

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

CTACGTGGCCCC _A_Concatenation ACGACTCACCGC _B

Target(s)

Target(s)

-0.931032727

0.89748071

2.714505633

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

Strong_X_mid

CTACGTGGCCCC _A_Concatenation ACGGCGTAAGTA _B

Target(s)

Target(s)

2.281871687

0.64263557

-1.459937014

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094078.1_5

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

Strong_X_mid

CTACGTGGCCCC _A_Concatenation ATCCAATCTGTG _B

Target(s)

Target(s)

-1.940780491

0.37442227

5.229533761

0.15190336

Virus_target

Human target

hvTR_Q2HR71

GLI2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CCTAAATGCAAG _B

Target(s)

Target(s)

-3.439922401

3.880482673

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025410.1_cds_YP_009094498.1_7

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

Strong_X_mid

CTACGTGGCCCC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-0.241272287

3.909200449

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR71

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

CTACGTGGCCCC _A_Concatenation GACTGTGGGCGG _B

Target(s)

Target(s)

1.239067547

0.56627226

3.450354443

0.04816017

Virus_target

Human target

hvTR_Q2HR71

MON2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

Strong_X_strong

CTACGTGGCCCC _A_Concatenation GGCCTTTCGGGC _B

Target(s)

neg_ctrl

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

Strong_X_random

CTACGTGGCCCC _A_Concatenation GTCACCCTCCTT _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR71

E2F5

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

Strong_X_mid

CTACGTGGCCCC _A_Concatenation Stop_2_B

Target(s)

neg_ctrl

1.456107457

0.72790325

3.552235532

0.17398177

Virus_target

neg_ctrl

hvTR_Q2HR71

Stop_2

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

Strong_X_termination

CTACGTGGCCCC _A_Concatenation TCTATCACAACT _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR71

TOX4

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

Strong_X_mid

CTACGTGGCCCC _A_Concatenation TTAGTGCCATAC _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR71

TET3

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

Strong_X_mid

CTCCATTAATGA _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

-1.337812988

0.83885356

0.488145629

0.87178775

Virus_target

Human target

hvTR_Q5IXR3

LEUTX

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Weak_X_Strong

CTCCATTAATGA _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.885988728

0.45505484

-3.464840821

Virus_target

Virus_target

hvTR_Q5IXR3

hvTR_Q2HR71

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

GAGATTGTGTCC _A_Concatenation AAACTTTGAGCG _B

Target(s)

Target(s)

2.27374001

0.68922551

-4.301297729

0.17069892

Virus_target

Human target

hvTR_Q2HR71

ATF6B

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

Strong_X_strong

GAGATTGTGTCC _A_Concatenation AATCGATCCTAC _B

Target(s)

Target(s)

-1.580928906

0.52243449

-3.483762303

Virus_target

Human target

hvTR_Q2HR71

PRDM10

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

Strong_X_mid

GAGATTGTGTCC _A_Concatenation ACGGCGTAAGTA _B

Target(s)

Target(s)

0.568603773

Virus_target

Virus_target

hvTR_Q2HR71

cds_NC_025350.1_cds_YP_009094078.1_5

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

Strong_X_mid

GAGATTGTGTCC _A_Concatenation AGGCTTCCCGCT _B

Target(s)

Target(s)

-1.421503567

0.82433714

3.170857119

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

Strong_X_mid

GAGATTGTGTCC _A_Concatenation CATCTGAGTCGT _B

Target(s)

pos_ctrl_A

0.261814006

0.96306008

3.688929723

0.23657467

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q2HR71

RWY_VP16_vIRF2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

Strong_X_vIRF2\u VP64_pos_ctrl

GAGATTGTGTCC _A_Concatenation CCCGTAGGGGCT _B

Target(s)

Target(s)

-1.866462843

3.909200449

Virus_target

Human target

hvTR_Q2HR71

TET3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

Strong_X_strong

GAGATTGTGTCC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

5.944790166

3.909200449

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_Q2HR71

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Strong_X_strong

GAGATTGTGTCC _A_Concatenation GAGACAGCTCTC _B

Target(s)

Target(s)

-0.488412088

0.938493

4.794341901

0.15241597

Virus_target

Virus_target

hvTR_Q2HR71

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

Strong_X_mid

GAGATTGTGTCC _A_Concatenation GGCCTTTCGGGC _B

Target(s)

neg_ctrl

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

Strong_X_random

GAGATTGTGTCC _A_Concatenation GGTGTCTCGATT _B

Target(s)

Target(s)

3.057939775

0.3372476

-3.350042954

0.34364709

Virus_target

Human target

hvTR_Q2HR71

E2F5

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

Strong_X_strong

GAGATTGTGTCC _A_Concatenation GTCACCCTCCTT _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR71

E2F5

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

Strong_X_mid

GAGATTGTGTCC _A_Concatenation Stop_2_B

Target(s)

neg_ctrl

-1.035843022

Virus_target

neg_ctrl

hvTR_Q2HR71

Stop_2

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

Strong_X_termination

GAGATTGTGTCC _A_Concatenation TATCGCAAGAAC _B

Target(s)

neg_ctrl

-2.13615428

0.72546447

3.865581172

0.14649582

Virus_target

neg_ctrl

hvTR_Q2HR71

Random_5

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

Strong_X_random

GAGATTGTGTCC _A_Concatenation TATCTATCGTGT _B

Target(s)

Target(s)

0.810644487

2.700278593

Virus_target

Virus_target

hvTR_Q2HR71

hvTR_P03259

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

Strong_X_strong

GAGATTGTGTCC _A_Concatenation TCTATCACAACT _B

Target(s)

Target(s)

-6.207145093

Virus_target

Human target

hvTR_Q2HR71

TOX4

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

Strong_X_mid

GAGATTGTGTCC _A_Concatenation TTAGTGCCATAC _B

Target(s)

Target(s)

Virus_target

Human target

hvTR_Q2HR71

TET3

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

Strong_X_mid

GAGATTGTGTCC _A_Concatenation TTCTAATTTCCT _B

Target(s)

Target(s)

-4.73677695

0.01468232

4.776309369

0.00426233

Virus_target

Human target

hvTR_Q2HR71

WDR76

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

Strong_X_strong

GAGTGACCTATT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

-1.078919928

0.68024065

1.974215267

0.23654449

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

core_VP64_a

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Unknown_X_vIRF2\u VP64_pos_ctrl

GCAGATTCGAAT _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

3.635690607

0.48868143

3.880482673

Human target

Virus_target

AK9

hvTR_Q2HR73

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

GCAGATTCGAAT _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

2.455930966

0.66495342

Human target

vIRF2_VP64_pos_ctrl

AK9

core_VP64_a

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

GCAGATTCGAAT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

2.243394991

0.70817197

Human target

Virus_target

AK9

hvTR_Q2HR71

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GGGAGTATGTCG _A_Concatenation ACTTGATGGTTT _B

neg_ctrl

Target(s)

1.328900573

0.49700987

7.513622093

0.03498942

neg_ctrl

Virus_target

Random_4

hvTR_Q2HR73

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Random_x_mid

GGGAGTATGTCG _A_Concatenation AGAGTGCGCTCT _B

neg_ctrl

neg_ctrl

3.366014058

0.10382793

3.502206768

0.17906841

neg_ctrl

neg_ctrl

Random_4

Random_1

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Random_x_random

GTCACCCTCCTT _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

-2.989132428

0.49700987

3.180465029

Human target

Virus_target

E2F5

hvTR_Q2HR71

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

GTCACCCTCCTT _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

-3.332327621

0.28630375

3.238855078

Human target

Virus_target

E2F5

hvTR_Q2HR71

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

TATTAAAAGTGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

0.152486738

0.91324404

-6.570098977

0.07359621

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_202

hvTR_Q2HR73

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

Weak_X_mid

TATTAAAAGTGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

5.637376422

0.20405616

-5.184750061

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_202

core_VP64_a

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

Weak_X_vIRF2\u VP64_pos_ctrl

TATTAAAAGTGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.091579619

0.96692351

1.302114269

0.64161874

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_202

hvTR_Q2HR71

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Weak_X_Strong

TCTGTACCAACG _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

0.748208589

0.78182953

5.921461068

0.00956535

Virus_target

Virus_target

hvTR_Q6XA69

hvTR_Q2HR71

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Unknown_X_strong

TTAAATGAGGGC _A_Concatenation ACTTGATGGTTT _B

Target(s)

Target(s)

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

hvTR_Q2HR73

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

RPRVPLVSTYAGDRYAVGGYGPEQSLVPPPLGLPLTLSNLQGEDICTWEEGLGNILSELQEEPSSSTRQATDRRRPRSRSPHGRR

mid_X_mid

TTAAATGAGGGC _A_Concatenation AGAGTGCGCTCT _B

Target(s)

neg_ctrl

Virus_target

neg_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

Random_1

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Mid_X_random

TTAAATGAGGGC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

core_VP64_a

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

TTAAATGAGGGC _A_Concatenation ATGACCCCTTGT _B

Target(s)

Target(s)

Virus_target

Human target

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

LEUTX

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

DLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV

Mid_X_strong

TTAAATGAGGGC _A_Concatenation CTACGTGGCCCC _B

Target(s)

Target(s)

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

hvTR_Q2HR71

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Mid_X_strong

TTAAATGAGGGC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

Virus_target

Virus_target

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

hvTR_Q2HR71

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

TTAGTGCCATAC _A_Concatenation ATAACTCCACGC _B

Target(s)

pos_ctrl_A

1.001593425

0.2685694

-5.981198825

0.12383329

Human target

vIRF2_VP64_pos_ctrl

TET3

core_VP64_a

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

LDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDML

mid_X_vIRF2_VP64_pos_ctrl

TTAGTGCCATAC _A_Concatenation GAGATTGTGTCC _B

Target(s)

Target(s)

1.437576689

0.31988807

-4.347452738

0.26334677

Human target

Virus_target

TET3

hvTR_Q2HR71

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Mid_X_strong

Joint_ 2_A/u splice_ AGAGTGCGCTCT _b

neg_ctrl

neg_ctrl

-17.95244707

3.880482673

neg_ctrl

neg_ctrl

Joint_2

Random_1

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

CPESRKGFGTSHKKKMRMPGCHEVRVQPCEDQESQHNRGIGLLGSFENLSKIAEHARARSGYFLTTAHPGYATGMAEQRGYLIKP

Joint_X_random

Joint_ 2_A/u splice_ CTACGTGGCCCC _b

neg_ctrl

Target(s)

-0.192334425

0.95452661

-2.866008684

neg_ctrl

Virus_target

Joint_2

hvTR_Q2HR71

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

TPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELL

Joint_X_strong

Joint_ 2_A/u splice_ GAGATTGTGTCC _b

neg_ctrl

Target(s)

-0.097806694

0.9798201

-1.837097072

0.55818445

neg_ctrl

Virus_target

Joint_2

hvTR_Q2HR71

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

PPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLP

Joint_X_strong

AAAACAAGCATT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_030656.1_cds_YP_009268803.1_88

core_VP64_b

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

AAACTTTGAGCG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ATF6B

core_VP64_b

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AAGACCGGTGCC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P08392

core_VP64_b

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AAGCAACGATAT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

core_VP64_b

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AAGGGTAAATTG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q69513

core_VP64_b

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AATCAACGAGCA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

C2orf81

core_VP64_b

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AATCGAGACCAG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q8BB47

core_VP64_b

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AATCGATCCTAC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

PRDM10

core_VP64_b

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AATGGCACTAGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_024711.1_cds_YP_009052522.2_44

core_VP64_b

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

ACAACGTGCATA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P10407

core_VP64_b

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

ACCAGTATTTAA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ARNTL2

core_VP64_b

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

ACGACTCACCGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

core_VP64_b

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ACGGCGTAAGTA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094078.1_5

core_VP64_b

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ACTCGTGTTGTC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q9QB97

core_VP64_b

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ACTTTAGTAACA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q69113

core_VP64_b

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AGCCAGGTCACC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

MESP1

core_VP64_b

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

AGCCATAAACCT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03209

core_VP64_b

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AGCCGTGCTTGA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

core_VP64_b

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

AGGCTTCCCGCT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

core_VP64_b

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AGTTAGGCTCTT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TOX4

core_VP64_b

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

AGTTGCTTTGCT _A_Concatenation CCCTATGTTCTA _B

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_2

core_VP64_b

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

ATCCAATCTGTG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

GLI2

core_VP64_b

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ATCTCTCAGTTC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

core_VP64_b

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ATGACAAAACGA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094074.1_1

core_VP64_b

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

ATGTGGCACGAC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ANKRD17

core_VP64_b

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ATTGTATCTAAC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

SMARCB1

core_VP64_b

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

ATTTGTAGACCG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

MYCN

core_VP64_b

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CAACGCATGCCT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

core_VP64_b

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

CACACCCGGCAG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P19893

core_VP64_b

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CAGTGACATAGT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

EHMT2

core_VP64_b

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CATCTCACCTAG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03206

core_VP64_b

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CATCTGAGTCGT _A_Concatenation CCCTATGTTCTA _B

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

RWY_VP16_vIRF2

core_VP64_b

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CATGCTAACACC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_F5HCV3

core_VP64_b

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CATTAGTCCCGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P06930

core_VP64_b

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CATTGTTTAAAT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

POLR1E

core_VP64_b

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

CCAGACGGTCTG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

core_VP64_b

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

CCCCTTAGGAAT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

SYNE1

core_VP64_b

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CCCGTAGGGGCT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TET3

core_VP64_b

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CCCTATGTTCTA _A_Concatenation AAAACAAGCATT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_030656.1_cds_YP_009268803.1_88

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

STFVRQMYLPIMMDPHELTFEVWENIKRIVMDTYLHKETSGIMAINITVYKDKELPLGELINNQIMVQVPCNVVFKYYKMGDIVS

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation AAACTTTGAGCG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ATF6B

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQ

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AAGACCGGTGCC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P08392

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAF

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AAGCAACGATAT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863712.1_1573

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GHTVKDSIESTRILKDSGFKIVYHIMLGLPGADPDKDLETIKEIFANPDFMPDMLKIYPTLVVETAPLAELWKRGLYTPYDTDTL

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AAGGGTAAATTG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q69513

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

NKNSETLRSRSRSSESDCKKRSERSCSNHSWSSGSTQKSKRVDIDFTHGAKSIPNEYEQKKSTNKFFKNKRRNARKRFSDDSDSS

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AATCAACGAGCA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

C2orf81

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEE

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AATCGAGACCAG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q8BB47

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

EPAKPSGNNMGSNDERMQDYRPDPMMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIESNNVEEGSNEDLKTLAEH

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AATCGATCCTAC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

PRDM10

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHA

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AATGGCACTAGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_024711.1_cds_YP_009052522.2_44

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

EGNLSSDVINRSFITNIAKIINDDKSTVEEQNAMVEAYAKQKFASHQYDYSNLLLEHRDSNGNIINYGLFRRVGNGTPKLTEYAR

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation ACAACGTGCATA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P10407

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RCYEECLPPSDDEDEQAIQNAASHGVQAVSESFALDCPPLPGHGCKSCEFHRINTGDKAVLCALCYMRAYNHCVYSPVSDADDET

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation ACCAGTATTTAA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ARNTL2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

NCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation ACGACTCACCGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863933.1_1849

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PGKIYESNLHFLISRLKNDGYNVVGHKLVGDNKDKIEEAIEEASKIADVIIITGGTSAGEKDLVHQIIREKGEIIVHGLKFKPGK

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ACGGCGTAAGTA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_025350.1_cds_YP_009094078.1_5

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LWLTILIALVGNHESTCMNINFLQSLGQINSQKRFLNFYTQQPPSYMVIRLVPTLQLSANNCTLGSIVRYRNAIKELIQPMDENL

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ACTCGTGTTGTC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q9QB97

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VAINLFNSEYILENIFIHSTTSFYSLNYNDNVINYNGLSRYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNT

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ACTTTAGTAACA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q69113

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

NNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVES

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AGCCAGGTCACC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

MESP1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation AGCCATAAACCT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P03209

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQ

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AGCCGTGCTTGA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863280.1_1236

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGGDKIIAFNSLSWDREDYVISPFELPNSQKTDEGYLARIKIPSIGYSECNPERVDDKVRINDLTLENSILKVSLNNDGDIISIY

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation AGGCTTCCCGCT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863028.1_914

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VKGQDMSFSGLLTAALRAAKKYPIPDICYSIRENAFDMLLEATERALALTEKKEIMVVGGVAASVSLRSKLNLLAKDWNVEIKIV

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AGTTAGGCTCTT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TOX4

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

EFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPV

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation AGTTGCTTTGCT _B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Random_2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DYDHESVHSCWKAKAAVYLYVSRTVRYKLVKIPKDSKEVKEVFGSDLSPTEFKKYLGYEKTSMLSQIIKSPRSYVIMSPSILYLM

VIRF2_VP64_pos ctrl_x_random

CCCTATGTTCTA _A_Concatenation ATCCAATCTGTG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

GLI2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLT

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ATCTCTCAGTTC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863839.1_1735

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VKVKIVATGMCHSDVNVFEGKTPVPPPVIAGHEIAGIVEEVGPGVTRVKPGDRVVSAFIHPCGKCRNCISGHENLCETFSAVRLK

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ATGACAAAACGA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_025350.1_cds_YP_009094074.1_1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

HFRTAERSPDCQIERIEVDGFEPGTYRIRTNARTPLTHGEVVALEEMADDIPEALANHTPFVDAQTELEECDEMEKFLEAIYSTL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation ATGTGGCACGAC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ANKRD17

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

QQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ATTGTATCTAAC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

SMARCB1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSD

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation ATTTGTAGACCG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

MYCN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENE

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CAACGCATGCCT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155862292.1_5

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

YPAEYGEEEREVKIEVSFDTYLRSKILIGSYLGISLPISRTLMLSRVKAVARQDILSISKVPSLFPQENPSGIVTPLIITVELLS

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation CACACCCGGCAG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P19893

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCS

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CAGTGACATAGT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

EHMT2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGAT

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CATCTCACCTAG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P03206

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

ATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEA

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CATCTGAGTCGT _B

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_b

RWY_VP16_vIRF2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGGGSGGGGSGGSDALDDFDLDMLGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGSGGGGSGGGGSGGGGSGGGGSGGGGS

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CCCTATGTTCTA _A_Concatenation CATGCTAACACC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_F5HCV3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CATTAGTCCCGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P06930

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AEGAEHQQKLTEKDKAELPLSIRDLAEALGIPVIDCLIPCNFCGNFLNYLEACEFDYKRLSLIWKDYCVFACCRVCCGATATYEF

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CATTGTTTAAAT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

POLR1E

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFV

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation CCAGACGGTCTG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155864195.1_2158

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PFASLYMFNRNLRDSLINANYTSLLKSIDATNIQIIFQYILSYLLLKRAINHQPTCIDDTRNNNCEELLRDLINEAYNYLNNLNN

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation CCCCTTAGGAAT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

SYNE1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLD

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CCCGTAGGGGCT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TET3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

APFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQS

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CCCTATGTTCTA _B

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_b

core_VP64_b

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CCCTATGTTCTA _A_Concatenation CCCTGCCTCGGG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CCGCCCTTATGT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ZFX

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CCTAAATGCAAG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_025410.1_cds_YP_009094498.1_7

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CGATGGCGGAAT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

KIAA1586

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation CGCCGGCATACA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_030656.1_cds_YP_009268729.1_14

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CGGCAATTGCTT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q9QB93

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CTCACGACAAGA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_G3G929

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CTCAGCGATATA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q5Y0Q4

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation CTCCATTAATGA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q5IXR3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation CTCGCACCGAGG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CTCGTTATGGCA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

NOVA1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CTGCCGGTTGCG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation CTGGTAGTTGTT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_F6KS47

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation EPICXV.47_B

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

core_VP64_b

3x_vIRF2_core

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

CCCTATGTTCTA _A_Concatenation GACTGTGGGCGG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

MON2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation GAGACAGCTCTC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation GAGTGACCTATT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation GATCGCATGTTC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

INPP4A

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation GATGGAGCTACA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P03209

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation GCAACGAGGGTC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

QRICH2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation GCAGATTCGAAT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

AK9

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation GCGAGGCAGACC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation GGAGGCACATCG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q87042

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation GGCACAGCTCCA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

DTX2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation GGCACTGTCGAG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P17147

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation GGCCTTTCGGGC _B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Random_3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

VIRF2_VP64_pos ctrl_x_random

CCCTATGTTCTA _A_Concatenation GGGAGTATGTCG _B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Random_4

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

VIRF2_VP64_pos ctrl_x_random

CCCTATGTTCTA _A_Concatenation GGTGTCTCGATT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

E2F5

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation GTACATACCGAA _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation GTCACCCTCCTT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

E2F5

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation GTTCCACGCCTG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ZFX

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation Stop_1_B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Stop_1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

VIRF2_VP64_pos ctrl X termination

CCCTATGTTCTA _A_Concatenation Stop_2_B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Stop_2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

VIRF2_VP64_pos ctrl X termination

CCCTATGTTCTA _A_Concatenation TAAAATTTATCA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

HSF1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TAAGATTCAACG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ZNF292

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TACATGAGGCAC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TACTTCTAGCGG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NC_025350.1_cds_YP_009094080.1_7

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation TATCGCAAGAAC _B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Random_5

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

VIRF2_VP64_pos ctrl_x_random

CCCTATGTTCTA _A_Concatenation TATCTATCGTGT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P03259

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TATTAAAAGTGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_202

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation TCAGCCGTAGGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q805Y1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TCTATCACAACT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TOX4

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TCTGTACCAACG _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q6XA69

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

VIRF2_VP64_pos ctrl_x_unknown

CCCTATGTTCTA _A_Concatenation TCTTAGAGGGTG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TRO

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TCTTGGTTTTGA _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

ZNF597

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TGATGAGCGCCC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

EEF1D

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation TGCCAGACGGTC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_P10541

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TGGCCCCCAGTT _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

hvTR_Q3I8P6

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

VIRF2_VP64_pos ctrl_x_weak

CCCTATGTTCTA _A_Concatenation TTAAATGAGGGC _B

vIRF2_VP64_pos_ctrl

Virus_target

core_VP64_b

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TTAGTGCCATAC _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TET3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation TTCTAATTTCCT _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

WDR76

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

VIRF2_VP64_pos strong_ctrl_x_strong

CCCTATGTTCTA _A_Concatenation TTTAACGGATTG _B

vIRF2_VP64_pos_ctrl

Human target

core_VP64_b

TWIST2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

vIRF2_VP64_pos_ctrl_X_mid

CCCTATGTTCTA _A_Concatenation Joint_ 1_B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Joint_1

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

VIRF2_VP64_pos ctrl X joint

CCCTATGTTCTA _A_Concatenation Joint_ 2_B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Joint_2

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

VIRF2_VP64_pos ctrl X joint

CCCTATGTTCTA _A_Concatenation Joint_ 3_B

vIRF2_VP64_pos_ctrl

neg_ctrl

core_VP64_b

Joint_3

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

VIRF2_VP64_pos ctrl X joint

CCCTGCCTCGGG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863778.1_1657

core_VP64_b

EVNWLKAIKVENTIRGIALAGKLEEFLDNIQDIVYLLSSERTLYFDELLLSNSIEDSIKKILEDGRKAIKNEINNEFSKDVNYIY

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CCGCCCTTATGT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ZFX

core_VP64_b

VYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLH

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CCTAAATGCAAG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025410.1_cds_YP_009094498.1_7

core_VP64_b

SVVYKNLQLGIPSDNGNVQEFKPLWSGNSVQTDLSTKECVDYIISQVNAHTLSLITLDIEEPTPEGVHDVSPALINSFLIAHFAL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CGATGGCGGAAT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

KIAA1586

core_VP64_b

DTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLG

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

CGCCGGCATACA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_030656.1_cds_YP_009268729.1_14

core_VP64_b

DGNVEIPLVQQNQQPVQPVLLPPPNQLVDDVQDQADSPMLAQSSNHMNTQEDVLSSDMLNLFDDIEWNDEFIQQVLNNPETIFPI

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CGGCAATTGCTT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q9QB93

core_VP64_b

SRQHAAYIDYALNRMKKMPIEMLGSDTITLKPYQHFVAKVFLGLDTMHSILLFHDTGVGKTITTVFILKHLKDIYTNWTILLLVK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CTCACGACAAGA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_G3G929

core_VP64_b

ADDLFDFIETEGNFSQLLAAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAEAAVLAAAAGATRPPRP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CTCAGCGATATA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q5Y0Q4

core_VP64_b

FATGSPRRRRSTVPRTDVSLGDELCLDASPSMTPSEALDDFDLTLLGDDDHAGTLDAAAYASLDMADFEFEQMFTDALGIDEFGG

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

CTCCATTAATGA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q5IXR3

core_VP64_b

FCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

CTCGCACCGAGG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863808.1_1697

core_VP64_b

AEGLKVEVKYSGYAQPLIFSSLKSFSSFNEILKGMYNHTVIESFIIDYGNRDVILDIFHNSKKVLECLELIPFIRFSILIEIDNN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CTCGTTATGGCA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

NOVA1

core_VP64_b

AFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTF

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CTGCCGGTTGCG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864303.1_2298

core_VP64_b

LIKIPYKTEKIFPSDVKGKYAYMKDTVIIIRNQSKVLYIDCAHCNLANYKPPSFLSNYIFEYEIMEGGEYCECIAKTLQEQLKPL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

CTGGTAGTTGTT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_F6KS47

core_VP64_b

SSGGVLQAKNALQIAKREMVLAHPLLGYLTKNASTFEESNKVAQLFSLNGYNPVDAAWYFAAWARGVWPKRRAIWLWGPASTGKT

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

EPICXV.47-A\u splice_ CCCTATGTTCTA _b

vIRF2_VP64_pos_ctrl

vIRF2_VP64_pos_ctrl

3x_vIRF2_core

core_VP64_b

GGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

vIRF2_VP64_pos_ctrl_X_vIRF2_VP64_pos_ctrl

GACTGTGGGCGG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

MON2

core_VP64_b

TWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

GAGACAGCTCTC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863833.1_1727

core_VP64_b

LREVKFMGMITDTFIHVGKYGKLKEFLGDKDGKSLLFVNVRSSVKFDKAIVRKNIIRDLITSESLRYPDNYSLLSYVFGDGNIMM

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GAGTGACCTATT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862583.1_356

core_VP64_b

HKIFPDGESYIRIPESVRGEEVAIVQSTYYPQDKHLIELLLMIEAVKNLGASKIISIIPYLAYARQDRRFKDGEALSLKIVLNLI

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

GATCGCATGTTC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

INPP4A

core_VP64_b

NSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKER

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

GATGGAGCTACA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03209

core_VP64_b

EMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

GCAACGAGGGTC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

QRICH2

core_VP64_b

RGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GCAGATTCGAAT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

AK9

core_VP64_b

KPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GCGAGGCAGACC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863098.1_1014

core_VP64_b

QWGDRSGALLSYWASTKENNFPRRIFTAVSSSVLVQDYLKKYNIEVVWTKVGSVDIAHKLMEEKGIAGFEENGGFIFPLHQYVRD

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

GGAGGCACATCG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q87042

core_VP64_b

RPKRSRKRSIDHESCASSGDTVANESGPLCTNTFWTPGPVLQGLLGESSNLPDLEVHMSGGPFWKEVYGDSILGPPSGSGEHSVL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

GGCACAGCTCCA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

DTX2

core_VP64_b

TTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIG

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

GGCACTGTCGAG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P17147

core_VP64_b

YALEAYMPEADRVPTDLAALCAAVGCQASETTVHVVVGNGLKEFLFAGQLIPCVEEATTVRLHGGEAVRVPLYPPTLFNSLQLDA

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

GGCCTTTCGGGC _A_Concatenation CCCTATGTTCTA _B

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_3

core_VP64_b

GAKNQLKISDPRGGDMILLYKNRGCMSETGSSVEVIQVSAVWRITLDNVNDPNLITEYGQKLPERTESDLGFQTERSQSENKKKQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

GGGAGTATGTCG _A_Concatenation CCCTATGTTCTA _B

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_4

core_VP64_b

LLLDRNSHLTCHIIKVNKLVVSAYSFINQFQKSQAQDCVEDVFDQWVINALLVTTNGGDAAAIFKSAQEGNSEGISDHWLHMDDS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

GGTGTCTCGATT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

E2F5

core_VP64_b

LTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

GTACATACCGAA _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155863816.1_1708

core_VP64_b

NENKLRDIKEKIEVKKRELEDLQNRIARLDQEIKNKESLASPEIRQSYERQLQEINAQLQKITAQRNEAEIEIRLLEKVLDQIRE

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GTCACCCTCCTT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

E2F5

core_VP64_b

DLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

GTTCCACGCCTG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ZFX

core_VP64_b

VVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

Stop-1_A/u splice_ CCCTATGTTCTA _b

neg_ctrl

vIRF2_VP64_pos_ctrl

Stop_1

core_VP64_b

***IIVNSNDQIILGYIHELKGPIRRYKNNKVVSDQCICSVEMLDRDTFEDLIFQLGHKKKEAYDTGISLQGVTVICVTKYEVSK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Termination_X_vIRF2\u VP64_pos_ctrl

Stop 2_A splice CCCTATGTTCTA B

neg_ctrl

vIRF2_VP64_pos_ctrl

Stop_2

core_VP64_b

***LIVTSDNSKFKPEELLIAEETSYQDKINSDSPENDNLMDVCSHILYAEDPGNKKNTSGWYSEPLKINKPMMCINAILMCVLE

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Termination_X_vIRF2\u VP64_pos_ctrl

TAAAATTTATCA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

HSF1

core_VP64_b

LSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TAAGATTCAACG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ZNF292

core_VP64_b

CFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TACATGAGGCAC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155864086.1_2031

core_VP64_b

PRKKIYTVKVLLPDFSTVADNIIGIRKARILPEFSEYIDADVIKALNRNLNAGLEESEGGMLLISIEEDQLQDLLKVLKGKVEVL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TACTTCTAGCGG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NC_025350.1_cds_YP_009094080.1_7

core_VP64_b

TWLAAPNTENEEDISVHLHTGSSCCIRPVDMCVLNETEAEVPHLLVPRANKFVFDDNPLDNEQIEIIDNVMIQSRLSGVDCLTIQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

TATCGCAAGAAC _A_Concatenation CCCTATGTTCTA _B

neg_ctrl

vIRF2_VP64_pos_ctrl

Random_5

core_VP64_b

PNYTEGNKKSRRKPKRDVKKSASHMKDLKTIIIKVKYFYNTSETIEQYESHPEYRIVAWDADIILDGFNFTDKAVSVEGSFKYMV

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Random_X_vIRF2\u VP64_pos_ctrl

TATCTATCGTGT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P03259

core_VP64_b

RTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TATTAAAAGTGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_202

core_VP64_b

MHVHVNLDKAAFLLENNMYEPEQFPGLIFRMDDPRVVLLIFSSGKMVITGAKREEEVYKAVKKIFDKLNELDCIKPIEEEEELEI

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

TCAGCCGTAGGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q805Y1

core_VP64_b

RGAAVAPARLREINYVRERLNLPLVRSAATEEPGAALTAAPALQTQRARSSGYFMTLIRVKLDAYSEGSGSEGAEVLREHAYSRR

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TCTATCACAACT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TOX4

core_VP64_b

LSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLH

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TCTGTACCAACG _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q6XA69

core_VP64_b

ESAKDTTSNSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSY

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Unknown_X_vIRF2\u VP64_pos_ctrl

TCTTAGAGGGTG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TRO

core_VP64_b

FGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGAL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TCTTGGTTTTGA _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

ZNF597

core_VP64_b

ASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TGATGAGCGCCC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

EEF1D

core_VP64_b

QHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQL

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

TGCCAGACGGTC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_P10541

core_VP64_b

RMLPDFFTGNWDDMFQGLLETEYVFDFPEPSEASEEISLHDLFDVEVDGFEEDANQEAVDGMFPERLLSEAESAAESGSGDSGVG

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TGGCCCCCAGTT _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

hvTR_Q3I8P6

core_VP64_b

GFYIDGKLFNEDLSSKYVTFTKNVIASDAVTKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Weak_X_vIRF2\u VP64_pos_ctrl

TTAAATGAGGGC _A_Concatenation CCCTATGTTCTA _B

Virus_target

vIRF2_VP64_pos_ctrl

cds_NZ_WFIY01000004.1_cds_WP_155862466.1_219

core_VP64_b

LLFIDEINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVKETENGKYIDWDGLAETIKYAVRLLDNVIDANKYPLKQ

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TTAGTGCCATAC _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TET3

core_VP64_b

PLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVP

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

TTCTAATTTCCT _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

WDR76

core_VP64_b

IEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMS

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Strong_X_vIRF2\u VP64_pos_ctrl

TTTAACGGATTG _A_Concatenation CCCTATGTTCTA _B

Human target

vIRF2_VP64_pos_ctrl

TWIST2

core_VP64_b

SPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

mid_X_vIRF2_VP64_pos_ctrl

Joint_1_A/u splice_ CCCTATGTTCTA _b

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_1

core_VP64_b

GGSGSGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPK

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Linker_X_vIRF2\u VP64_pos_ctrl

Joint_ 2_A/u splice_ CCCTATGTTCTA _b

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_2

core_VP64_b

GGSGSSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPA

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Linker_X_vIRF2\u VP64_pos_ctrl

Joint_ 3_A/u splice_ CCCTATGTTCTA _b

neg_ctrl

vIRF2_VP64_pos_ctrl

Joint_3

core_VP64_b

GGSGSNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKD

DALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGGSLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDL

Linker_X_vIRF2\u VP64_pos_ctrl

TABLE 11 validated screening of engineered Gene effectors encoded by functional biological sequences

Bar code	First_screening_l2FC	First_screening_ padj	Search_method	Ml_type	Start_Point	Peptides	Base average	Log2 fold change	lfcSE	stat	P value	padj
													AAACCAATTGTA	5.119999321	8.35E-43	EMC	xgb	Is known to be	ICPSTATPGNSGSDALDEFELDMEWGMLLDDFDLDMLDLPAEEKHCMDTCTDFAALDGDCLFDDMPDHSPSPDDDCLFENFPPLQ	4526.575317	5.954022431	0.407373466	14.61563632	2.23E-48	8.51E-46
TAAGCTGCCCAC	4.323888801	1.70E-38	EMC	cnn	Is known to be	PPFPATQVSGDTPEINNDIDQGDGVNFDCDMLESDAHDDFWLDMLGAMQQPEFDLADLDLVHGGWVEGFNWMNGDDMPEPGPGAG	2701.590351	5.564089658	1.311157407	4.243647352	2.20E-05	0.000217981
													ACGGATTACTGG	4.081262297	5.07E-38	EMC	Both of them	Is known to be	AIPDVDQFNSFEDFFQDMWDTSLPIDFDTDEFNTATTDFDDFLKLLGDNQAGIPSTPEGAEMQFHVHTGCPPVASQVSSHDTIKL	31536.81878	5.84757675	0.276898957	21.11808876	5.42E-99	2.69E-95
CCCAAACGCCCA	4.043357552	3.19E-29	EMC	xgb	Is known to be	PDDPDEPVSPNNLATTLMYHQLGTDGNVSGGGPCGDSPLDLTLFSLHDDLSAEWPEFDPATLDMADFEFDQWKWDDLGVSDLDDV	5829.540689	7.431268254	0.407779489	18.22374211	3.34E-74	5.53E-71
													ACCTTCGCCTAT	4.627459008	2.16E-26	EMC	Both of them	Is known to be	DQPPSEEGFPPHWKEPTEPSDQGYDIPSLDEFLDDMGLVSPMTNMMSGLMGYNDLGTIDQSELAELCMLDIEQYTSDAGEGGLWF	7122.193991	6.505983853	0.529034468	12.29784493	9.30E-35	1.25E-32
TTAACTTCATTC	4.215728925	4.59E-24	EMC	cnn	Is known to be	SPDSDWPHFSGRSDPIPDDVPVGWELPDLNFYIPDFALDDFDLDMLGASFACDEQNDMLHNPEQEETPLQTPRPTEWFYGAYNID	8326.709328	6.145640058	0.518191907	11.85977622	1.91E-32	2.16E-30
													AATGCGGTACGG	3.351681816	7.70E-24	EMC	cnn	Is known to be	GWHNEDMPDYTHMLLNSMPAHETQLAWFPPSPDTWINTNPWTDMDLPDLDINDASIQELLNLEVPVQDPDGWDSISPGFSSMEPE	9837.306217	4.340889006	0.368288226	11.78666245	4.57E-32	5.04E-30
ATGTTCCTCGTT	3.428566629	1.89E-22	EMC	xgb	Is known to be	TPGETEYGPRLTPSPMPTDLGPDTFNFGFDMFAGLDTSPEEPIPSLASDLDDYLHTVDHQEGCCPDALDDVSYILEDLFDFMDRN	8213.662548	4.499396353	0.57951825	7.76402875	8.23E-15	2.09E-13
													GATACCATTTCG	3.583504325	1.16E-21	EMC	Both of them	Is known to be	GQSEPSMSCDFFNPFTMGAEPEYSSNDPPRFSFAPAKFTTPECFQELLYDDLDLNPSTDGEDVIMAMADALDDFDLDAWPEWPSP	3640.935737	6.106570803	1.498131723	4.076124089	4.58E-05	0.000438971
AGCAGATACTGC	2.843425118	1.45E-21	EMC	Both of them	Random arrangement	HAQRNASMYTGFDCDSDIGPIPDCFDTSPFMDTCSDGWCHTLPHDTEDDIWMQLDFPVFLGDAPIEGPELTPDFISLLDDAIDQW	8519.847519	4.226007071	0.479086816	8.82096298	1.13E-18	4.02E-17
													ATCGATGCACGA	4.716581793	2.72E-21	EMC	Both of them	Is known to be	AHPSQPPEEYWDDFLLDMLMSDDHWIGTQYPELMHALDDFDLDMLGSDTYDMSCLTTEDFQAGGSFGGLSALCGSEGPDSPGHGD	8069.509948	6.74353574	0.944896049	7.136801714	9.55E-13	2.06E-11
TCGTCTGCGCGG	3.330713788	6.25E-21	EMC	xgb	Is known to be	SSPASFEIPILETPDYALPSDGPGVNDDEDIIEMLLASAPPTGLVLSDQLEGQPPSGSCDEAGSLSMPHTYWGNMFEDMFGDSMT	5404.119194	4.162820957	0.381208385	10.9200666	9.24E-28	7.27E-26
													ATACCAGTGCTA	3.154160636	7.37E-21	EMC	cnn	Is known to be	VGTLPSDSENFPRSDTPPQFGMSDDNLCEMTPSDTGDSFDLHLNLPDDQAALHALLQEAGPLDWDELVPLDDFDMNFTLNGMYDQ	4805.577306	5.016679734	0.52645192	9.529226787	1.58E-21	7.55E-20
ATGCAACGATCT	3.265181601	1.05E-20	EMC	Both of them	Is known to be	GQMDDSNTDITDDLLAPHLVSMMDEWLGDCDHIEGSVLDLFNDHEQTLPDLGILEELLIGDATAPEYQAGQCGNIMTVDDPPHLQ	2819.264236	5.032015858	0.605503943	8.310459272	9.53E-17	2.88E-15
													CGGTGGAGACAT	3.055986445	1.16E-19	EMC	cnn	Is known to be	PPVGSMPDYPHELNHRAWELLFGEEAHNGDNFPSHPSPELVHPSMLESASWDDFDQDMLKFMGYDDLWSGPVQSQILDDLHLFED	13677.24098	4.987848349	0.315029298	15.8329666	1.84E-56	1.14E-53
CGGGGCTACCAC	3.167911667	1.37E-19	EMC	Both of them	Is known to be	IGECQLPSFDGFPALQPPVEAEFVFDFPEPSEGGEEMCYHDLPDYDVFGFEASTPTNTPRLAPGDNPEWEDYDSLFPDHFGFGWD	3300.124699	4.716206537	0.459201795	10.27044447	9.58E-25	6.41E-23
													CCCATGCGTTCT	2.804166835	1.93E-19	EMC	Both of them	Is known to be	SSENPSNLMSPGLDETGGSSEPYRDHPFPEWDTFIDDLMLDDDLPDPFTWTPGVEDTGDCTDQPLSPLWVDTYFTWDWPGENYAC	6491.65921	4.213714539	0.429936178	9.8007908	1.12E-22	5.89E-21
CTCGCAGTTCAA	3.12800265	2.13E-19	EMC	Both of them	Is known to be	CEAPMEQFDPGCNIALVAGPLDGLGEYDFNDLDLNWFEGYHLTDHSCEQLIDFMDPDPTDFDWDDLADPSFGTSPLTPDPPIYPA	3966.283148	5.265035131	0.577915539	9.110388587	8.21E-20	3.36E-18
													TCTAATGCTGCC	2.729384692	2.21E-19	EMC	xgb	Is known to be	SGGSSPSPQYGSPEDSLLDLVDHEEHVCPSDDWLDDFNDLFSDTAELWIPTELNNWEPYGRASPSHGSSPKEASQDDPIGWIPDM	18350.7544	4.227883191	0.304669771	13.8769369	8.74E-44	2.55E-41
GAGAGGGGATGA	3.10774722	2.68E-19	EMC	xgb	Is known to be	GHGDELMQSPDPRAQMPFLFADPLGTPALGDCAVPDALSDFNLDTLGSGNEHMFIWDMNDVDAFDHMLDDMAKDMYDCEQLGLDI	7056.450094	4.845202056	0.539042438	8.988535432	2.51E-19	9.48E-18
													AAAACGGCGAGG	4.066138534	6.45E-18	EMC	xgb	Is known to be	AAFSDLLSPEELWSDTHFDAEFTEDWWDEINCLENPAAPGGAAMDSGSGLDDCLPPVDHLEINWPSPLQDEIQEFLDLGDDCDLS	2783.459791	4.946102784	0.442942307	11.16647181	5.95E-29	5.00E-27
TGGTGTTGCGCG	2.98162189	1.53E-17	EMC	xgb	Is known to be	PDAAQSVEDDNMTLGGEWFTGWGYDFFAGFDHIEGALLDDPPTVEYDLDINELDSILLALSAMDMPRPKEDAAECGSTQSGATTK	14490.43403	5.559255815	0.453908623	12.24752193	1.73E-34	2.20E-32
													ACACATTGAGTG	3.203441202	1.59E-16	EMC	xgb	Is known to be	LCGSELSLDSLDALEPSGVSMPSNSDECALWDPLYDLPDNFDWLEEIDRSLGIPPLPPTSMGPDLCGFIWSLEHENTTQDWGHHE	4458.715243	5.056965826	0.523655592	9.657045396	4.59E-22	2.34E-20
AACTGTGCATGA	2.880537949	2.89E-16	EMC	xgb	Is known to be	QCTGIDEMSTWDDVMTHEYDTQTQFDFPEPLEGSVSPFRPNLGPLQYQELMAEPAEDPSWSWPYDQFDLDALGLDALDVCWYPPN	7382.676254	5.035426693	0.47729093	10.55001547	5.08E-26	3.70E-24
													TCGCGTGGTCGG	2.947195769	5.28E-16	EMC	Both of them	Random arrangement	DLTQYEVPSCSDQFIGEHFAWPVPPDLEFDQPFEFDQMEYFPAGDTDATNAGDDWPPDLSGIEEIFTIVPEDHVDMFAGLDMLFS	8658.178596	5.04575372	0.397944076	12.6795548	7.68E-37	1.27E-34
AAGCGCTTAATT	2.68966923	5.93E-16	EMC	Both of them	Is known to be	GGGGSHPDEDLNIATDGSIVHPLCVHDELDDLTYPGALDTYDGDQLGIFDLFDFDLDMLGGTIPNTADPVISYLLQQVTHDTNDI	11013.84417	5.419354249	0.358795093	15.1043154	1.52E-51	6.26E-49
													CCCTCCAAGTCC	2.865739411	8.85E-15	EMC	cnn	Is known to be	IDATRDLIGPLDEIASDGWDTSYPIDFDFDQFNTETTDFDTLHELYDLDYTAPEWPNEEAVSGSDPIACLPDPSVGIIVDTQEWQ	4427.018617	5.301234582	0.384541921	13.78584308	3.10E-43	7.54E-41
ACGAGCCTCTGG	2.628355527	2.04E-14	EMC	cnn	Is known to be	ANDNAASAEIIYWDTLSPCHKWLPDDFDLNMLPEDMLDEFDCDLLVSDAIHQFDLEMLGYGQGGPEMRHGLNIYSDDYVIIPSGE	13604.29819	4.344654087	0.374666137	11.59606822	4.31E-31	4.36E-29
													TGCTGTGCTGAA	2.805230688	4.74E-14	EMC	Both of them	Is known to be	TTTASGGSSAGPPMDLDNLGSLDLDFFDLDYQHEPAHPFFDLDMHGLDDLYDCLAMYEDLCKADEGDCNDAGFMDPMGGSLGSNS	4669.428431	5.40637343	0.603104015	8.96424712	3.12E-19	1.17E-17
CGGAAGGGATTC	2.578421581	5.38E-14	EMC	Both of them	Is known to be	DNPPHSHVDPHQGCFLDTALPTIVGCQTIEPTVCSDILDLFDPYALGSEALDTDNLDTLGIDDLLRECCAGVASWQQEPEPPQCD	5871.215801	4.834202421	0.988770769	4.889103293	1.01E-06	1.18E-05
													GTACATCTCTAC	2.66285405	6.66E-14	EMC	xgb	Is known to be	LSEPEGSPGTSLDTWPVNYVTWDQVFALQGTPAEALPHDVNMTDDLDVDQGLMEMLMTDESELETLLDCLLPVETQLPPAYGPQD	4066.873224	3.115188943	0.472894893	6.587486964	4.47E-11	8.33E-10
TACGGATTCAGT	2.250071279	6.69E-14	EMC	xgb	Is known to be	STGAPEGSLDENFNMIPGPLLPLPMQEDPWQLLPDMGTYPSGDLLGDLPDLGELSELLCPEVSMAIESQHDFFGEGSELELFASG	9579.904441	4.608126833	0.462518818	9.963112105	2.21E-23	1.29E-21
													TGCACCAGGATC	2.310260534	6.78E-14	EMC	Both of them	Is known to be	PDVDNLTGCDFDTLLNHLPGIMDQNIHDLMEPSTQPNQGGASASLLSDGSQLDFDSLYEWDADASAGEWQHLEAEAWEFVCHTFS	7842.133206	3.790652903	0.426763899	8.882318566	6.55E-19	2.37E-17
ACTCTAACCCGG	2.702462319	1.15E-12	EMC	Both of them	Is known to be	ECPGGDDNIPAPEGYPLNNENDDCLDNHLMMDYSNIDDLLTLCGVDLSDIPSPGPPVGMSFGPFDEWFDDIDGGQNSRTAGSLLG	5051.781196	3.936630884	0.458083393	8.593699188	8.42E-18	2.80E-16
													TGATACCAGCGG	2.216500899	1.74E-12	EMC	Both of them	Is known to be	DTPMHSEMQAQHEGEMDLFHDVGWEWPDLGFAWYEDALDPFDWKILGADALYDADILASPTPASDYNLLDEHGGFMDDDFYFDFN	9456.127685	4.279782435	0.429531954	9.963827827	2.19E-23	1.29E-21
CCGGCTGTGGAT	2.750477544	2.14E-12	EMC	xgb	Is known to be	CDSMDNDKNSETMDGLGTLPVVCDFDLDYNFDSSQLQEFLGNAGPDFDALWDMLDTYMSEDDRALFTEGAGPVCEEYGQPASWHC	5183.521362	4.444169636	0.686567256	6.473028819	9.61E-11	1.73E-09
													TTTTCAAGGTCT	2.376180384	2.63E-12	EMC	cnn	Is known to be	HLCLDCTIVETLGSGDLMLEQHPSLECPQHSGESHNLTFPATDLLAQDALDHFDLDMTMWLEEWSFNIDSADWDLAGMESGGSGI	6104.022365	3.478543963	0.396589166	8.771152278	1.77E-18	6.22E-17
AAGTCTGCCCTA	2.722695953	3.76E-12	EMC	xgb	Is known to be	VGALLGLDSYPKTTPSLMDLSVCEYDDPDGSLGTKQVNDLDGLDMLGSRLCDWMDLDNTAFDNLMPAEGAMPDEGGDIDWFMMDL	3401.096216	4.007689605	0.320074839	12.52110169	5.72E-36	8.60E-34
													CGCCAGGTCAAT	3.422410728	4.22E-12	EMC	Both of them	Is known to be	TENNLSPMANWWDEQGLMDNDQYSDWPDLQELPPDLDLMTEALDLGSPLTPELHEILDMFGIDECGNHDSAAGDGGVVYMTKGCQ	1794.392624	3.83666413	0.981855364	3.907565484	9.32E-05	0.000850924
GACCCTGTGTTG	2.159322453	5.90E-12	EMC	Both of them	Random arrangement	ATAQDDEAPLQVHLDEVIIPNHEPCADDSPAQEWDNWFDMLEWTDAYNHAFSSMPSFPWFEDVALWSDCNIDTVEQPDEPPCFDI	21497.78239	4.543120079	0.488102452	9.307718213	1.31E-20	5.73E-19
													CTGAGAAGGACG	2.928688534	1.21E-11	EMC	xgb	Random arrangement	QIYRFTADCTPIQCDEGQYELDFDWDFDLLEWCDPTHMTPNDEWTPEPPQGCSSSVHGFTSEFEEEYLMDQWEEFMPTPPPHHDL	2319.866342	4.481402153	0.324984114	13.78960372	2.94E-43	7.54E-41
ATGTCGGCTAAC	2.763198266	2.28E-11	EMC	xgb	Is known to be	GWEISGGAGDADGDPHPGQAFSGPMDFDAALPNIPTFDFDDFPLFADLESFMEPLGQEGLDCLGYDASLMKAVQENLGDLTQSSW	3109.53508	5.10638125	0.457186064	11.16915332	5.77E-29	4.93E-27
													CCTTCCCCAAGG	2.366018466	2.88E-11	EMC	cnn	Random arrangement	AILENWVIPDSSSAVVCGDFSTDELQPTHVMHAWEEPPHQMDISLEEFDNFWQEQAQHDFDAEMDEWLSSEILSIFNDAPPLGTF	7098.031021	3.939302993	0.35008659	11.25236758	2.25E-29	2.07E-27
GTTGTGTGCGGC	2.837886627	5.02E-11	MH	Both of them	Random arrangement	PLCPLGAEPQHGVGWEPCPLSCEPQHAAPPIHCYLWPDNADFLDNGAALDEVPFCEIDIFDGDEFPEIMDLGVNWLEEWDPFSES	6806.653545	3.462881162	0.448271471	7.724964411	1.12E-14	2.77E-13
													AGATGGCGCGCG	2.31643741	6.61E-11	EMC	xgb	Is known to be	GHADNPAGSSLLPSPVEPDPTQQDLLAPWSLPDLDGFNPSLWFDMESISDSETQLGDHLDVDVYALLETMWNLPDPDEIPELPKD	5995.386258	3.865825672	0.482492241	8.012202777	1.13E-15	3.14E-14
CTGATTTGGCTC	2.319825022	9.13E-11	EMC	Both of them	Is known to be	ECEICMALDSLDEMFEQWHYVDRELIQGPSNEVIAPLITLDLMSEATYPAPGVWGTTLGMTGETVDDIFDWNIEDYLEIDFSELM	4439.357544	3.025815306	0.347732722	8.701554716	3.27E-18	1.11E-16
													CTGGACTGCTGT	2.533045923	1.14E-10	EMC	xgb	Is known to be	TYAIWPEPPPLDLHLEDLCACLEQEANGEDTPFESDAAATFDAMLDFDAALEDCDTGMADSPASLNFSLDMGDSDYFSNWMTMML	4588.405827	3.107137775	0.364739068	8.518796171	1.61E-17	5.19E-16
GCGGCTCCCTCT	2.74392385	1.43E-10	EMC	cnn	Is known to be	APPVFDDICETLDEAEPQHGYPDHTDGLVHQVLEPELEAFDLGMLGDDSLDNFDLTHMWAMLEEEAWGESPAAECNQSVQEGQGV	4197.168894	3.46885743	0.427285237	8.118364806	4.73E-16	1.38E-14
													AGATTAAAGCCT	2.751187468	2.26E-10	EMC	xgb	Is known to be	TEAEEEASTPTEPPGSEFTDIMCDWLPCEGDTPPSDALDGTLLDILGQALDPDPWPHMNGSIAHLEFDLDMGYWCSPVQHQPEMP	3593.698148	4.393520926	0.275196928	15.96500718	2.24E-57	1.59E-54
CAAGGCTAAGAC	2.69982613	3.81E-10	EMC	Both of them	Is known to be	CSHDRNHSTFEMFPLSESTWDVICPDAHDACLPTTTEMLPEDLYLDSPLEPELMEILDDFLGAECQLNDGFIADFLLGAGDENEP	2731.405984	4.755116421	0.442425166	10.74784345	6.07E-27	4.63E-25
													TGCGCGTCGGGC	2.281598856	4.20E-10	EMC	Both of them	Is known to be	CDVTSEYAYNQLAEEHLIPMEPHRPLCTSGPLSDTFAMDDFDSPDLNDQALDDVPALWDFFDALNNAPNAMPLLDMLTDFDLHNA	19826.41598	4.606464851	0.342756109	13.43948284	3.55E-41	8.00E-39
TTGGTGGCATTC	2.215076721	4.40E-10	EMC	Both of them	Is known to be	FDQMWLYSFNSIMMANHEWDNQPSHDGGPNTPPPDHETMIPDLNLDWLDTPEEPDDVDMFLNDWGLVSQMLDLQDCVDWPMPYDG	4873.884194	3.216486583	0.32216115	9.984092082	1.79E-23	1.07E-21
													AATGGACTGGTT	2.033061136	5.67E-10	EMC	xgb	Random arrangement	EHTEFMATGMDQGESNDYCWMYDLACECMADSGSPNISPSLTLSEYEEFCRLLPDMDTVDVGGPWAAQEPLFMHEIYESDEPQDL	7592.360319	3.845906972	0.314701379	12.22081386	2.41E-34	2.98E-32
AAATACTGCAGG	2.494192536	1.04E-09	EMC	Both of them	Is known to be	LGDFDLDSMLLPAVEPPCVAEPAEPPESELSSIYRPADWLAQADWHMNTTEDALSSDVNQFLSELFEPDNWENWVGENINYGLDE	3690.590661	4.873338259	0.342450862	14.23076653	5.90E-46	2.09E-43
													CTCGGGCAGGTA	2.604935509	1.15E-09	EMC	cnn	Is known to be	QDMDDAEAASTGEFPVTDWLEGPLPRQHGIASGIEGFGSTGPSNLDEDSWLDYLPMVDQILSDEYLPIADVFNELDDLLDFSCTM	6507.295553	5.120077565	0.544311251	9.406525321	5.13E-21	2.27E-19
AATTTCGACAGG	2.587277291	1.31E-09	EMC	Both of them	Is known to be	VDWPDEGTEFEHTDYFQNYVLPDVDIDDLLALLGDASPSKEQMGESTVPRTDMTLWGYLSDGAMPEENWKDGFCDWEMGGGEGTR	3826.28169	5.079305712	0.322580517	15.74585396	7.33E-56	4.04E-53
													CCCGTAACGATG	3.003944082	1.49E-09	EMC	xgb	Is known to be	AREAIGIKTPDGAGAMACAEVFGSELFPTGDLGDNDALDDFDLDDLLNDEFVMPDMLPDILDTQFLTTLQPHSFDFMDGHGHGHL	4889.82076	5.527868326	1.429443823	3.867146254	0.000110116	0.000992249
GATATTGCGTTG	2.418220494	1.60E-09	EMC	xgb	Is known to be	NEAFCSTICETTGEAWIDPDPRGPQPWEYAFEELCASPMFDTSFDDLIATPWYLEGLQPDHLLSIDPVCSEILGDTEENKTMQHE	2952.157287	3.696882182	0.498807356	7.411442794	1.25E-13	2.92E-12
													ATTGACGGCTCC	2.163176182	1.97E-09	EMC	xgb	Is known to be	FDDQSMLGLLDNFTPECLSSPSEQQDLCPEEDPYAFNPAGSISGDIIDELMLCEIRMDPWSYHTPADEPWWHPHCDLPQPSYEMP	6979.376905	3.851480205	0.370503752	10.3952529	2.61E-25	1.87E-23
TGTGCAGCAACA	1.982487689	2.13E-09	EMC	cnn	Is known to be	QPYVYPSVNTNISPSEPAHEPNENEWLGWDNSLAWNVGSLNDEFWLDLLTAGQPCFELPDVGGEPMNTGLADLMEFWAASEESMS	5305.44634	2.899576542	0.385370452	7.524127828	5.31E-14	1.28E-12
													GAGAGATTCCGA	2.551333283	2.57E-09	EMC	xgb	Is known to be	AQAAPAAVEQLDDTISLLLQFGDDFDLYKGGLPAGGPWHGGPYYSTDSGGDDFDLDCIEPWVMEDSELSDVGLLDTDIADLILQG	1991.521231	3.532971756	0.404654784	8.730829087	2.53E-18	8.80E-17
ATCGTGAGTGTG	2.262308478	2.85E-09	EMC	xgb	Is known to be	KTPVTVDTVSTCYPLERCNTVAELFDAPMAQDYTQWDNALELCQELFLDWDTEFNLHHAFEDDIMAGFDMLDQFEGTAEFLPTSP	6234.613598	3.814696977	0.372463012	10.24181422	1.29E-24	8.51E-23
													TGCGTTATTACA	2.647816103	3.30E-09	EMC	Both of them	Is known to be	PWVCPRPMGDSDAVAPEIDTVGEWHFEIPDVDIINSPPVLHDLLGESSTLPDWALPWMDDQFCELDLMGQLGGPPAEFDEHSVPY	2575.609906	4.597906052	0.495412721	9.280960814	1.68E-20	7.24E-19
GGACACAGCAAT	2.294005924	3.42E-09	EMC	xgb	Is known to be	HTPRGSMQFSTFCELEAVDFVCPASGETPCLHDEEELLDWKDFDDLPQLAPMMDVGDLDSIGPGWSWLDSYTSPIEEFLGCFDAE	3320.657289	4.600019242	0.473741745	9.709972336	2.73E-22	1.41E-20
													TATACCCTCACT	1.868296462	3.78E-09	EMC	Both of them	Random arrangement	EGGPAWFTQPPSQDQGLPCCTCSAPECMIMPVAEWECLSQPIADFEQFTQAYLDNLNRDMSGEDNMSEQWCWDFMNSFDDTAWDT	11554.24409	3.364970384	0.270474183	12.44100395	1.57E-35	2.22E-33
AATAATCACGGA	2.544483495	4.16E-09	EMC	cnn	Is known to be	VMQMDVEATGCCDTTDTNENWLAGCEWPLPEPYAHQDMSSLDNLLHSDLESIDTIEMWAGGDTLALLETFMETMEMPHDYHDGPY	2479.653659	4.652697059	0.59547403	7.813434047	5.57E-15	1.44E-13
													ACGATGATTTAT	2.141150192	4.91E-09	EMC	Both of them	Is known to be	LDEKCSMGFSDFIPTCPLNPMCGFMEWSSEPTDVEFDIPPTWLDDLTSLDVSDVVGIFDDLAFPPPAQTPEDQAHYSAGGGGTQG	3402.944369	3.435930164	0.362052739	9.490137204	2.31E-21	1.07E-19
GCCGGGTATACA	3.489565564	5.20E-09	EMC	xgb	Is known to be	SPLRAPDIEFALPAWEDGLDLDWCFDATFDDFNFDTTVEDAFLDIFNWMEGPCNILSELGQGEPPPTRCQPEQGEDQYETPVSYP	542.8187585	4.939402207	1.400626722	3.526565736	0.000420987	0.003365177
													GGGGGTTGAAAA	2.560598509	8.35E-09	EMC	Both of them	Is known to be	WSYPCGIEWPGPYSSSGRNSSQTQPRSDMTDLDLDNFLDLLKTDVESIDLGDFNDDLLGDSDTLDLNQYLFPVDEEDDTCMQPDV	2204.636885	5.224970759	0.46637011	11.20348548	3.92E-29	3.47E-27
TTGTCCCCCGGT	1.808854031	8.64E-09	EMC	xgb	Is known to be	PGLPDHVTPCPDDEFNLYDNTQHPFDMPEPELCFEEMPPLDLFEILEISLTADINCPAVDTNSLEAFDLEDIQQTDNNPFTYFNE	9957.513956	3.441297694	0.282201216	12.19448216	3.33E-34	4.02E-32
													ATTGCATTTGAT	2.066328081	9.47E-09	EMC	cnn	Is known to be	MATNSPVDSIRDETSPNKLEGSHIDPGDLDEFLDHMDLDDLWKTLWKDDQIMSHNGSINSCLENDMDVLFMHCGDFEIPLEHEEW	5277.930376	5.124824125	0.369942108	13.85304354	1.22E-43	3.36E-41
AGGTCTGACGAA	3.074632322	1.26E-08	EMC	cnn	Is known to be	GTRVNSQPITTEAMDSVAQSQAHELYCTPSEPFDTPCLPMYSLDSDDSLMGPTSDEAIGALLDIESFFDSILGGPSLGTTDDDPM	1207.401103	4.525256318	0.584285374	7.744941976	9.56E-15	2.42E-13
													TTGGGAGGAGAG	2.56784145	1.26E-08	EMC	Both of them	Random arrangement	KQYPQGVHGAIPQDPDAPAWPEFEDAEMFFACEACDLSPPETNTEDPELQPHSWEPLLAYEPSFISETIDTMWGCWDNWPWPDLA	2008.069279	3.00813829	0.498879331	6.029791376	1.64E-09	2.60E-08
TGAATGGTCCCA	2.009243552	1.28E-08	EMC	Both of them	Is known to be	DWWEHFCPTTDWGDPLQGELYTPWSDVPLDQIQPIEPTAGFSDADLFNMLFHSDPSSQFDISHEDWLVNEGGSMLPTTPQESENV	4160.500342	3.197160301	0.378186936	8.453915228	2.82E-17	8.95E-16
													ATTTCTATATTT	2.494322665	1.32E-08	EMC	Both of them	Is known to be	AEPSGSGMPTSQGWITGPQTPHLIDWITHDDIPGWPTDPSKDMSTLELDSSKFSLLDMISDEWLTQGSFEWPTDGEGMTGQGGGE	2358.52868	5.034214528	0.396416383	12.69930997	5.97E-37	1.02E-34
CTTTCGACGGCC	3.558736338	1.61E-08	EMC	Both of them	Is known to be	TAEVIPYVDCPEASANAPTGANALEQPDLYDLASGSTWPLYASDMEMSDFLGDFCLDMLGMHDDIMWHNTLLDMDVLDDWDLSEP	1161.258135	4.778532339	0.882487466	5.414844427	6.13E-08	8.26E-07
													AATTTTCATATT	2.247778994	1.91E-08	EMC	Both of them	Is known to be	QEQVDLEGFALEQPIDDSNLEMNSPDGPVPQSAPRISEIGSNWFDIIDELGSPDMFDWLWCPPTPWDDICFTLDDLITDPQFEDH	3759.934356	4.584710178	0.453036696	10.11995324	4.51E-24	2.83E-22
CCGGTAAATGAG	2.475600864	2.03E-08	EMC	xgb	Is known to be	PPSDTDQWEFASLDFFDYDPEGPGGDGGGEPTHSTLLGMWSDLHLGDSNLTESMPSPELPGPVGALLETWDISTMAEWLDIPIDG	6081.704663	4.964694822	0.287881085	17.24564439	1.21E-66	1.20E-63
													CTCGGTGATCTC	1.907001695	2.04E-08	EMC	Both of them	Is known to be	AQTEEIQTDCAVGSIPQLTISPLDWHLDMDPHQPMFSGSLSQSHPTEIDDLGFLPEDLDNLAADVDAFTEIQNGMSLAEYYLWME	6613.611521	4.213494922	0.550889685	7.648527537	2.03E-14	4.96E-13
AAAAGCGTCGCA	2.134682329	2.07E-08	EMC	xgb	Is known to be	DPSLGCLQPASLPIDPASELINPSPSRDSNYEPENHGSDLSPMVIQEMPDLGGLWMNASELAMDWREFTACDSDLWDLLGDGSDL	3787.236222	3.691808033	0.358778117	10.28994762	7.82E-25	5.31E-23
													TGGCTCTCGCGG	2.103824635	2.07E-08	EMC	Both of them	Is known to be	GAAYQDDTLSYLSELVEQQLQQYHMEQWGSLWDSPATGHSTMSSDLELPDLGDLTELLCPPADPQLSSHFTGLSNWIQQVDGCNE	8089.092324	4.623577399	0.423171264	10.92601929	8.66E-28	6.92E-26
TGGGGGGTGAGC	1.817920948	2.07E-08	EMC	cnn	Is known to be	GGAMTTRDDTSAISMPCFGGSQHAGDHPPSETPNEALADFDLHLLGDSDFAGVNFDWMNKGCDVADFFEICDAAFGDIRGFPEQS	10869.03137	4.181253231	0.580617637	7.201388597	5.96E-13	1.32E-11
													ATAACCCATTTC	2.448547857	2.24E-08	EMC	Both of them	Random arrangement	ALNVNAIEGSEHGDMPLMSELEHHVTHCPEWWYNDEAADFLQWFEETTNEYDNILGDHEFDPFQEDYNMPVCWPNPDFQGDINSP	7573.912503	4.600962998	0.576603402	7.97942395	1.47E-15	4.07E-14
CTGCTTCATTGC	1.938567473	2.37E-08	EMC	Both of them	Random arrangement	ALQQHTTPVPSHSEIADIMQDWPTGLIQEDLTISPPPPETQAFWQTLINEFFNNTAMWGEYGDHNPDEWAPCGSGGDTDQNPITQ	7178.99148	3.314809881	0.216570867	15.30589007	6.98E-53	3.15E-50
													AACTCCCATTAA	2.577766341	3.31E-08	EMC	Both of them	Is known to be	VNPYFSYEDITPMTGFAPTQTCNDELPELFLEPQVAESFDEAELEMPSPHMNDFDLDMLLPDEWPPFDDWLTELMHFMDVQHAHL	3016.204519	4.523971905	0.459272214	9.85030612	6.83E-23	3.64E-21
TGCTGATTTTGT	1.811972777	3.49E-08	EMC	Both of them	Random arrangement	MDPDNMLFGVEAWDHCFMGVEHMDNVQEFAETLGFNDMDFDDMPNDIELLNCLGSPDSPAHTSLWCPGYMEQTHDPEPTSTDHSG	7774.705425	3.233147015	0.256304436	12.61447936	1.76E-36	2.81E-34
													CGCCTCTGAGTA	2.13798058	4.33E-08	EMC	cnn	Is known to be	YNGCHPGSSNWFGDQMYTQWEEGMDLDDILGSIGEITPPTSHSLDFFTDFFALSPMNSETDLEWADFFEGQEWHGQDGCTHTEWE	3470.035309	4.747080906	0.368741237	12.87374568	6.33E-38	1.12E-35
TCTACGCGGACT	2.655393578	4.93E-08	EMC	Both of them	Random arrangement	ELGLYGELPHRAIGSELEEYPCVWSGQTPNTQHKDANSLMSCQDFQDILDAGFEDFTQGVDFDDFTYSVLDDAWLDQGGATNQWM	2056.983884	3.268110773	0.599765711	5.448979012	5.07E-08	6.94E-07
													ATCAAACGTCAA	2.144529239	6.48E-08	EMC	cnn	Is known to be	PPDSMDCIGSPGVGVAGPSSPHSESQDYQGWETSTHEYNLEDDLQLLDLETYSPGSPLTEIEPDMLARNWFGECLFGDWVEWPPE	3372.299367	4.32565456	0.655259831	6.601434051	4.07E-11	7.62E-10
ACAGTCATTTGC	2.024450252	7.00E-08	EMC	xgb	Is known to be	YNANHMEPPTPPTTFFTDNLLSNEDWGCWNGPNDSAVNELFSVWGPQAAPPEQSPSFIGPSFDELMDWSYGWPCGGEWSLNWEDW	3302.487431	2.744518629	0.379299743	7.235751346	4.63E-13	1.04E-11
													TATTCGATCCCC	2.436808735	7.03E-08	EMC	cnn	Is known to be	EMPEADQQSGSPWSNLLFEEVGHEPDRSPADLDQDMFSGGVTLGLNWYDLNDLMDFDCMDFNDLMNGEGETFPTLEGFLTGICSP	1806.514894	3.260025097	0.50318379	6.478795939	9.25E-11	1.68E-09
CCAATGGTGGTC	1.922808608	7.76E-08	EMC	xgb	Is known to be	ATGRDCAEFQCDSPGSVSTSNWLQLVEDMLDPDPEGLGDFDWREILEPDCVMELDDPAFASLDMASQEMPMPGSVGFHDDLGQQE	15420.14925	4.001409923	0.229334815	17.44789567	3.57E-68	4.43E-65
													CGAAAGACTTAA	2.262321474	9.87E-08	EMC	Both of them	Random arrangement	PSSNYDGTGHSIITINPDLDDCQSQDEPGWLWDTMTHAESQEPIPFSSVEDVFRPFPCDDLGQFQEDFYTFPGDFFDYIAWGEMQ	1991.724518	3.64291212	0.493232958	7.385784068	1.52E-13	3.48E-12
AATTGGCTTAAT	1.777729074	1.13E-07	EMC	xgb	Random arrangement	LPEADDDFCPSESELFSQIMSLWDDLQYDDPGADLCQCILDDCIIDNDIFVNAFITSGGDSPSHQSGGRFNHNDSPQAFNPCESH	8726.604729	4.04323507	0.28580354	14.14690338	1.95E-45	6.45E-43
													ATGCTCCAACCG	1.784880055	1.96E-07	EMC	xgb	Is known to be	PGPEPEDVGMGALWGETSGLGDSEQGDVFSDLDLDFWIGSLACDMDESLAMLDSVGHKLCSIYPNLPPSPLSLPDAWGQGMDQEM	6851.794893	3.919629579	0.333516693	11.75242397	6.86E-32	7.39E-30
CATTGGCAAACT	3.345768534	1.96E-07	EMC	Both of them	Is known to be	NWFDELWAEIMDDELPNLHDVRWPQGDYQSIEAQEPLSDDCFQEMLCDNALMGNDGLPDDANLLTWLESEWSASGSTDEWPAQPR	987.2371565	4.45969524	0.540535131	8.250518769	1.58E-16	4.72E-15
													GTGAGTTGCAGA	2.168095575	1.96E-07	EMC	xgb	Random arrangement	NPNDDDYNPGDDNISWDPSDDDTMHTSPTSPVNPFDAPLGYDFNLDDFMFAQDFTDWPVFEEWMGHFEMPEWCFDPMYEDISFQM	2269.113821	3.659358342	0.481179063	7.604982481	2.85E-14	6.92E-13
TCTTTTTTACTT	1.903270723	1.96E-07	EMC	xgb	Is known to be	ADMADFSGMECVDMFTEVELSPDVFDFELPEYTTQEMSVSEDLFLDADTFGTPQPAPAQIPGDPYIQASVRNLAAWMLEDPWDFV	7590.062409	3.965355189	0.421199489	9.414434951	4.76E-21	2.12E-19
													AAGGAGACAAGG	1.811236875	2.01E-07	EMC	Both of them	Is known to be	AVPVTQEFPCQAYDMLPEQHVEAMDSHDSTLPPGQTGSMTCPMLALDDLMIDDILPGLRLSPNLCDPFECEFGTSFGFPVTPLDQ	5676.289028	3.259391301	0.339405223	9.603244374	7.75E-22	3.88E-20
AACCATTCATCA	2.049910382	2.40E-07	EMC	cnn	Is known to be	TNIPGKHINNWADDPLWDELLDMVPTHPCWFPMADHLEGANLFDVTMDDLEHPDLGDLGFNIFWNDALDSNHGEGQGQNESRVND	2441.593596	3.062256948	0.381310155	8.030882231	9.68E-16	2.73E-14
													CGAAACCGGACA	2.851536203	2.40E-07	EMC	Both of them	Is known to be	SFAATNMASPCSLDSTSCSHPERGHEPMPAWLNLDMFSMTEDLTTRSPLTWDLDNLLDTFDKDPWGNDAMNDVLGGDGCYTEAPQ	919.9137865	2.89632772	0.68415404	4.233443861	2.30E-05	0.000226754
TCCGCTAACCCA	2.379026112	2.40E-07	EMC	Both of them	Is known to be	YPPVPSTTESATCTPHDGWPTETPEDFNFDEFNTDYTGFDDFLMLLCDNSNGIQSPWEGAQMPEFVDSDPVCDAPEVEGNGWIWL	3486.114268	4.578939803	0.483513381	9.470140822	2.79E-21	1.28E-19
													CAAGATTGGATT	1.646640029	2.75E-07	EMC	cnn	Random arrangement	CEAHHCSHEGDHSVGMPHMGELHDAYAEEGVNLPNSPVIDSVDCDSASSYLDLGSSQWLKEDYLDDNLLAPFAWDTIWDFEVPDW	10125.18577	3.659044994	0.275316601	13.29031734	2.63E-40	5.68E-38
GAACGCGCCAGC	4.040319734	3.02E-07	EMC	xgb	Is known to be	EPTDLYDVPGGLPCDIDAEWNISGCLGDSDLESSGLFSGSTGSPMDWNVDMKDFDMDMLIPPCFPPADSDDGQEPPDLGYPLFLL	344.5465224	8.723555848	2.96993445	2.937289019	0.003310954	0.021705141
													CTCTCACAAACG	1.672319365	3.78E-07	EMC	cnn	Is known to be	GWGNLDATTSVWYDLPSEYWSCPDFEDVSWYCDIPLESPDLVDASLFDLFNSLDDPYAIANPQIDPESSEPFNTDIPGAEYHMLG	6522.24041	2.66580763	0.280332086	9.509463094	1.92E-21	9.05E-20
GATTGGTAACCG	2.384617935	3.88E-07	EMC	xgb	Is known to be	QLPEWQLTADQDPLLELPDAAQYDLDALCTRPLKSDDDTLGSAWYNFSDFQSIWGEVSGMWDAIPSSDYYEILDDSLMTLLGDDD	1806.550522	3.282744095	0.520666485	6.304888422	2.88E-10	4.96E-09
													AAGACGTTCATT	2.02767736	4.14E-07	EMC	xgb	Random arrangement	LDPGLVPMGDIQALQQDRALEHARGAGQVGQPFQSLYNTPDSLHDLWYGDPATVEPWDTYDPCDFFYSLLENEPEIPHSQNTPHN	5873.792872	3.161547422	0.411187695	7.688818179	1.49E-14	3.64E-13
GCTACTGTGATT	1.740767815	4.16E-07	EMC	xgb	Is known to be	LAWTEHPLHDFCSIHNDGFDTSEPIDWDFDEFNDCFTDFDDFLKLLGDNSPSKGGGGGGGGEPLEAFDLFIPESNGDDVTVLDAY	6048.366555	3.859590593	0.489319911	7.88766308	3.08E-15	8.20E-14
													GCGGCGACGCAC	1.963052381	6.44E-07	EMC	xgb	Is known to be	TETDGVPGPAIMTLELHPADASYATDALPPPFDLDMLGSDADDNFILDMLSGANLPCLPCLDQQPWMDQCIDFDDFDKFDDFISK	4029.311531	3.377272986	0.42626877	7.922872199	2.32E-15	6.25E-14
CGATCTTTTCGA	2.258605242	7.44E-07	EMC	cnn	Is known to be	ASDPPIPYLPGAENRCPAFLPNTFPDSGFTEFNPLDLNNLQIEDIHPWEEGLGNILSELEEWPKHFDTFECDESMDPMWCPGGGI	1555.363598	3.967149536	0.623695058	6.360719853	2.01E-10	3.53E-09
													CCTACAAGATGA	2.223179167	9.55E-07	EMC	xgb	Is known to be	LDNHEGADEPSDEFPLEGFAHHINDYLNYVYEKECPTGPSSASLPDLYDLEFDMPPLDGMPFWPEVNFTSVLGPTAESANPPSSD	1921.043527	3.614663023	0.301099982	12.00485966	3.35E-33	3.86E-31
GAAAGCCCTCTT	1.707842058	1.43E-06	EMC	xgb	Random arrangement	CCNMSQEPIWEDCIWQEARATVHFVAPQQDALSNANLWPDTPYDTEQISFPSLGDTPWDWFEPFPEFLDTTATPPLDIPQFTEPL	3735.639747	2.827623102	0.255103393	11.0842238	1.50E-28	1.24E-26
													TCTGGCCTTCAT	1.895517456	1.66E-06	EMC	xgb	Is known to be	GGGGSCIDTEGFPDWLDDAMGQISELPPPSNLESSAPTALVEQMGMELPCLSDLSELLCEHDEFMAGSAQLDDLDLLGQGEFKYP	7153.626361	3.75502671	0.362827957	10.34933124	4.21E-25	2.98E-23
ACCTCACTATCG	1.813800909	2.33E-06	EMC	xgb	Random arrangement	DPFPDMSDPLLDMWICNPDAICHESLSTNQQQGQNFPDPEDNPHDMPFLEFVLNELDFYPICEDVKMQEALYLDDPVANEKNFDH	3495.016113	3.313142576	0.530493141	6.24540134	4.23E-10	7.20E-09
													AGAACACGCGGT	2.078129918	3.22E-06	EMC	cnn	Is known to be	RPGSSNGAVAWPPAAEAPMENVPPHLCTPDELDLDFFSGNLGLALDSQLLSEDVLNLNTFLNMEPEDLGFVLDDAAGVCDLSYIL	5930.616091	3.838680335	0.551811911	6.956501403	3.49E-12	7.23E-11
CCAGAGCGCACT	2.117722525	3.86E-06	EMC	xgb	Is known to be	GSLPDVADLEDHEWGGFLSDWEYTGDCPKGLEAWDEKSLGDLFDQYVDGCENDFIEDDGSGMGLVDLLLQMDASSGEDGSMLGGS	2970.72502	5.262293891	0.534158341	9.851561774	6.75E-23	3.64E-21
													GAAACTCGAGGA	1.911802186	4.59E-06	EMC	Both of them	Is known to be	ADALDTSGPVENWLNWLPDDACYYPDEPWPPPLESFAVEPTIKEILEESLPADGFEPLCLTPDAEAFDADLTMEFGWLPNMVEGE	3607.494045	3.691619614	0.49832931	7.407992144	1.28E-13	2.98E-12
CAAGGGGCTACT	2.014298187	5.45E-06	EMC	xgb	Is known to be	EEEATALLWGMSPMLLNPDGADTGPGGPPPIQDLDDFNLSLGWLDEQKAVPILEVLCSEDPCWEESAAPGWTLDDFLLNAHGPLD	5525.023769	3.67104978	0.368716217	9.95630138	2.37E-23	1.36E-21
													ACCAATTTCCTC	1.84509684	5.51E-06	EMC	Both of them	Random arrangement	IENATWDACECYDCDFLDNLWPYEDSFQWTPTPDVSHNFDNPRDSPIFEELFAGPTFFGDMLCRDLEDLDEYNQEYELPPPHIDL	5595.417127	3.488281304	0.298527427	11.68496085	1.52E-31	1.60E-29
CCAATATTGGAA	1.785236464	6.29E-06	EMC	xgb	Is known to be	AVGSSDSWGLLDMPYQLDVMDHARLVESGALLDLDGFDDFDLTLPTDRDAADDMLSDLIDFKGQQALPPPPMDTYALGEDGDPCF	2537.812213	3.603052718	0.446779993	8.064489847	7.35E-16	2.08E-14
													CATTGCACCAAC	1.901821121	7.23E-06	EMC	Both of them	Random arrangement	CDIDSSLWAFEHFLEDDQFATCSNMPVDPLLDMTGDEFSGGDLFDWFDWDIAPCIHPMTYDQPDGPHHPYEWVFPEELTPPWSGP	3219.445846	3.473876631	0.342449125	10.14421232	3.52E-24	2.23E-22
AACGCGCTTCTA	1.837774515	7.36E-06	EMC	Both of them	Random arrangement	VGIVPTWPLENEAQPCEPMAIHESQACPADSTAYNPTPSEWDFDTAINWDVWNYSSLLDFSDENMWGSLYDWDPAPCATCMGDFS	3434.004471	3.884353619	0.339526366	11.44050657	2.62E-30	2.55E-28
													AACGGTAAGCTG	1.563895116	8.44E-06	EMC	Both of them	Is known to be	PDQTAQDFWLANDFDFDFFNIEYTDLDWWQWLSPPAGPTDEQQSNEYMASDYFMDLPFSPLSADDYTWATAHYPFNLGDANEQEG	12072.30137	3.193746273	0.345438024	9.245497162	2.34E-20	1.00E-18
CGCTGGAGTGGG	1.818887982	8.75E-06	EMC	xgb	Is known to be	CHDNVCPGPMVEEPPKENLPEHDGLDNLLGMDYYNIDTLLTQPLTDLDPPLCPGAFGDTWQVEEQASEGGLGDWGDFSDIQWTLG	4681.507255	3.887523955	0.248714316	15.63047926	4.51E-55	2.24E-52
													CCAGACTCGTCG	1.832910189	9.09E-06	EMC	Both of them	Random arrangement	DGHVDTDAEPPMENWIPMLFDTWWEQCHQLPPNHEDLTTYDPGFNLLDQVLEDDICAQMFDMPWGPEARPSDQFMLMGWPMQETD	6604.85817	3.735657694	0.417514701	8.947368043	3.64E-19	1.36E-17
TCTAACTCAGGG	2.628891059	9.46E-06	EMC	Both of them	Is known to be	EFRHTEPDPESEAQSWDEATNANEDWPLWELTPWTPSPEFTFLMGEDYDLEDLEVHLFSGPFQDIDFMHSEDLLAGEDASSPLNE	1526.057761	2.426025006	0.454585637	5.33678323	9.46E-08	1.24E-06
													CGAAAACACCAG	2.358184889	9.63E-06	EMC	Both of them	Is known to be	FEHVPHYLHSGAPRVDMDVLPTLCYDASPGEVHTYALDDFDLNALDFSALWDYDDPAPMDPMDTYILAPFCGDGGSPSWPIPFEG	2126.907921	3.906690322	0.497832154	7.847404577	4.25E-15	1.12E-13
AGGTCGCGATCG	2.798191137	9.91E-06	EMC	xgb	Is known to be	DATWHSLTTIGNDNEGPCNEWDDGLDNLLGMDESDFFDTITQEPRDLDIWLPYIHGVMMPQPTEGEGPGEDPCPGYLDIPLSESQ	971.6006904	3.518934311	0.747656682	4.706617885	2.52E-06	2.79E-05
													CTCAACAGCTTC	1.666562722	1.17E-05	EMC	xgb	Is known to be	GGGTDALVDLLSDYIPPLAPSLGNAEPLSEPPTWVTEMLLENMLWLSAATPDQDDPGNIGGYTEEMHGDSICMWSELGFDGGQGT	4116.017498	2.78820114	0.352623126	7.907028587	2.64E-15	7.06E-14
TGTATGTCAGGT	1.411624758	1.17E-05	EMC	Both of them	Is known to be	AQMDHACFWETNGFDTWTDTGADDLPQVSWGSIPATPGATPDGPSHAGILDDILPMYDHLDGCLQDWPSPMEPMDVWAHLWYQLE	10295.74889	3.859525977	0.345169488	11.18153865	5.02E-29	4.37E-27
													GAGCAACCTTGA	2.063704342	1.35E-05	EMC	xgb	Is known to be	DDPFNSYAPYEWTVDELPDHPGGQSFATQPHPVLSGETDAMDDDPWSPLMGDVDLFGLLTCSPTPADTPQEALDFLEYPCDLGDG	4575.864432	4.02122563	0.348429397	11.54100562	8.20E-31	8.12E-29
ATTCACTTCGGA	1.88972354	1.54E-05	EMC	cnn	Is known to be	ANKGHTTHLGESHSNDKDAPAVPGLTYPWCTMHSQAGSPSPDIWDELMSPVSLGDGLLSNPIGDDTNHMCWDMLFDFDSYITWDS	2979.313261	4.064341316	0.425829422	9.544529124	1.37E-21	6.58E-20
													CTGAGCGGAGTA	2.026204578	2.20E-05	MH	cnn	Random arrangement	AGVCHSDTQISGDGPGIMDVGPDASMQHCEQSPQGPVAGDWEQPTAEFNRMEQEWTGEMHAELMDFLLAWIQCDDLGATDMPWVG	1632.715796	3.570991347	1.457797228	2.449580283	0.014302282	0.075406501
CGTGAACCCCTA	1.558909953	2.27E-05	EMC	xgb	Is known to be	WHNYDEAMPQSWTDPDLKTVLTTLDFWDLSVESFFAPSMDEQTQAPPTDESLGTTGNTPGEDVGMFPRTELWDFLLDDMGEPTSP	9781.280304	2.839488753	0.287713457	9.869155182	5.66E-23	3.08E-21
													TCATTTCGATGT	2.314362348	2.29E-05	EMC	Both of them	Is known to be	THGPEHFDTVASGFAIDDFDMGMLFDSAPCWWDCHALGSDQYDLFDLNLGDPSPDAAMYDFAWDTFCLDHEAGMAYQDPAGTDQT	2033.948036	5.571513968	1.937173934	2.876104138	0.004026169	0.025746699
TCTTTCCCCCCG	1.565888767	2.37E-05	EMC	xgb	Is known to be	SADTEPVPAEPGSQCPKWPGEWLMDDWLDVSAFPDFDLDMLGDGLLMETVSEPDPYAPSKELDDMLDNFGNHFMNALRADDWMYG	6520.857242	3.51278242	0.271717002	12.92809206	3.12E-38	5.74E-36
													GACAAGGCCTCT	1.55475138	2.65E-05	EMC	xgb	Is known to be	TQIPPVEMPGMGFDCSLDDDLPPLGSLSPDESDWLFGGPHSTHPWWDCGDLCPDYMDPTTGGWGSTDGCADLEQLLQGSMWLENE	7034.610545	4.052621254	0.454234926	8.92186184	4.59E-19	1.68E-17
CTCAGCGAAGCG	1.903295497	2.70E-05	EMC	xgb	Is known to be	PPELLEGMHRTNDNTQTQHDYCGFGYDTSAFDDLFAPDGDWAGTLFEWLDSSHASIQELEDCVPWPYPPFTGNSETDLEMEPIWP	1256.753073	2.772910306	0.480485027	5.771064962	7.88E-09	1.17E-07
													TGCCGCGGAACG	1.550552008	2.70E-05	EMC	Both of them	Random arrangement	GGSDSQAEDHGELPQLGYAGSIYDVDDRDLAIIGLNPASFHLCDEFSESNSPAPADCLDPGHEWAEQFLDVWDFVDDMFDFSSGM	6852.212856	3.221406373	0.242709107	13.27270499	3.33E-40	6.74E-38
CCTGACTAAGAG	1.70795474	2.91E-05	EMC	cnn	Is known to be	AIHVAPTGMGDMQEWLYAECQAEEAPWRPVNCLEMALDDFDLDQLGMDFLWDVDLDPAAHSMLPSIANICVSDPFQGGAQGMDGY	3070.144892	2.798586276	0.30983766	9.032427743	1.68E-19	6.58E-18
													GTGCGTGATCGG	1.680160079	3.32E-05	MH	cnn	Random arrangement	PGPMSFVEEHDNLPMLHLGIPMDNVVTPPQMGEDHEWPAPNLTEYSEQILEQIASNNTLFDEQFSELLETWDLYDNSEPLGDPFV	3645.562259	4.165582067	0.523691177	7.954272001	1.80E-15	4.93E-14
GCTTTGTCACAG	1.773945171	3.87E-05	EMC	xgb	Random arrangement	DDIVPPHTPMTFCPYWMPWEDSSGPGCVSDQCIIGDPLPVAAMQDGIDEDLSFLGMMYDEDWECPPFCVNLLSSMDQDSLPPWDM	3436.428329	3.020404911	0.38314662	7.883156866	3.19E-15	8.46E-14
													AGTTTATTCTGG	1.56091292	4.00E-05	EMC	Both of them	Is known to be	PAPQPAYFAKMIDGQLNEDPLWDFMDFDLDIPWDSFFHGAASPIDLEDYSPPPHDQDWQSLDASLSMEGVSQLDDFDLQDMYTVV	6508.593345	3.401720274	0.481398143	7.066334428	1.59E-12	3.37E-11
ACTACCTAAGTG	1.610510245	5.77E-05	EMC	Both of them	Is known to be	GLIDTTVDIPGSPQIDEMFYEHNFEPEHVSNWGWQPGQVLQQLLGESSNLPSLEVHDAGQDLPTLMEDLGYLGLLPPLEYDEDFC	4208.271112	3.033807383	0.362785508	8.362537411	6.14E-17	1.90E-15
													TCTTGCAGTGAC	1.388775892	6.72E-05	EMC	cnn	Is known to be	GQGGTGIPMTFGNMSQTDLSIGGANDHDHTEPPSTANPGCWMSTWFPDVDSILQSDWPLVDMFQPVPDDEVHDPSLQTHEFDEWW	6647.544681	2.642347074	0.297827207	8.872080892	7.18E-19	2.58E-17
CGCTCCTGTGTT	1.424430879	7.08E-05	EMC	xgb	Is known to be	GPTSDPGPKSEYLDVFDLFDLDMLGSDDEEGADWDMQAPKVNEDLSLDMLATSEDDCLPPVQDPSDDLCQYNNWMGLGSPMGSLS	5753.615376	2.631191121	0.289519825	9.088120727	1.01E-19	4.09E-18
													CGTCCACGAGAA	1.986976204	7.82E-05	EMC	xgb	Is known to be	GGGAERFTQPETPDGPYMDLASWLQGLGQEFPLAPPMPLLPGLLEEWIDIEIPDTSGSGDNMWEEVHFCSPPLDNSFDLWGPPLD	1300.566011	2.873242445	0.768330608	3.739591284	0.00018432	0.001594221
CCTCCGCCGCGC	1.496304604	8.09E-05	EMC	cnn	Is known to be	GGGDLGPPISFTPTLEEIEDYTTNFNVPIDDHPDAFLPTVWDLAAVWEDIDLITGPEEELSWEPYPWQIWGDGGGESSSSPPGFK	6065.915292	2.986526468	0.246894762	12.09635408	1.10E-33	1.30E-31
													GAGCACCATCCA	1.770117122	8.98E-05	EMC	xgb	Is known to be	TDPVVPCASGPQNQCSTPTHQCESGHIEDDSQCMDMFDGWLEMDIINELESALRDADWLDDEWTLPVIPAGLDDLCGLGDPGDFQ	2171.113064	4.862623763	2.04822165	2.37407107	0.017593164	0.089888371
ATTCTCGAATCA	1.89451365	9.51E-05	EMC	xgb	Random arrangement	EPDFDGFIEHALNFLNSMDTNLAADYEHPQIEPDTNAQLTAATQPAFHAILPDFYWDAPGECFSDFDWLMSITEHNNFESDGMVN	2598.07551	4.135865313	0.406564698	10.17271135	2.62E-24	1.69E-22
													CATGGATATAAG	1.621173747	0.000100345	EMC	xgb	Is known to be	AESSNTTPGPLAGSTFIFDSYCIGWPQYMPNVPPEDLRESQFPQYSEEFQDLDELICDQDLGAEPWTWPWSPTYDALLSDIREDW	2768.487444	3.03666882	0.499391675	6.080735769	1.20E-09	1.94E-08
CGATGTACAGGT	1.956041694	0.000107179	EMC	cnn	Is known to be	YGGQTNTTTQAQIQELGFPMEPQRPPVAENISLDSGNQLVHYTLNSLGLDDPWGYNEGARDEPIHYYLDWGAYEMDLDDFLDWSG	3889.355596	2.921636635	0.32377667	9.023616903	1.82E-19	6.99E-18
													GTCTTTTCGCTA	2.214140505	0.000122125	EMC	xgb	Is known to be	HYDMSAEEPMEIIPNFDKEFDELFPCFPFHEGDFAIDVALDACQDLFWLDPPDGPWQPPLASQEWLQEDFAWPHGARSPGQVTQE	1177.804586	3.959176575	0.431830783	9.168351889	4.80E-20	2.02E-18
AGCTCAGGCCTA	1.825671902	0.000126691	EMC	Both of them	Is known to be	LDTGEQQPPTQESLQGWFNPPPWTNQIPFFDALDDFDLDMLSNADSPGPSFIDVHPLWDALPWPMCKPPVGVGQDVPWGDFPDFL	3067.451939	3.775756643	0.453104285	8.333085264	7.88E-17	2.39E-15
													AGAGACCGTTGT	1.467695509	0.00013304	EMC	Both of them	Is known to be	QPAQTYQETDKQFDNVGPGIRPRAGALQPGPEAITTEMLCMEDMTQLSLGDYAELCLPEGDSSDMAELSMLMDWWLSGDADNTFG	5671.127841	2.49485807	0.416711201	5.987019455	2.14E-09	3.35E-08
AAACTGTGGCGC	1.325417524	0.000133481	EMC	xgb	Is known to be	PQLSEYDGPLAASQDSAVSIPDMVLLPATYDEQWNTDLSFDYNDLQELDDLGDLCDLHFQLLPPMDDTEGELWRCFETEFGMSMG	7418.118402	2.852774502	0.385627616	7.397744313	1.39E-13	3.21E-12
													AATTTGTGTCTG	1.8751855	0.000134213	EMC	cnn	Is known to be	PDDCCWGDDIPFDVSQVPSLEATTECLGLSQGDFEGLLDLPDPIALPDESGPVADWMSFLNGCADLEPLHTGGMGQSSNLEDPYA	3129.552826	3.89429416	1.452141107	2.681760156	0.007323595	0.043624681
CTTAAGGTATTC	1.633637673	0.000140831	EMC	xgb	Random arrangement	ELGASTPEMDPVSANHAADVMQERSIPDNTCNMCPQADSFLRQWLGDLADPFLEEFAQSFNPDDWLPQEAWDWHLCPGQYGENNG	5049.950134	3.609228936	0.318590719	11.3287322	9.46E-30	8.84E-28
													GATATGGGGCTA	1.390468858	0.000153842	EMC	xgb	Is known to be	GGSEPLNEINENWLNFPLCAEFSTSDEHMLLDPLYALDDFDLTLMGIDDLAPTYPAISDTHRIENTNHLYHQPQTPCHICGLGWC	5462.468111	2.949783165	0.381514571	7.731770657	1.06E-14	2.64E-13
GGATACGCACTA	1.871554369	0.000165393	MH	cnn	Random arrangement	SVFYDLTPCMIMMMAMSLRMEFGMDFETETWWCPEQIKPPPWTLRPLNSSICGYHCHADANWYKPHIGHFDYETSSQIWMDTEKF	487.9275826	-1.11453848	0.534105974	-2.086736591	0.036911952	0.15990877
													AGATATGTGGGA	1.717663604	0.000189751	EMC	cnn	Is known to be	EDPWACDLEWLMEFINADAWGHYVDLATLDEMLDPGMLDDLWLDKWAVAASTDVVGHIDRPADPGSSQMGMHDGCMHNSANDWEQ	2840.659252	3.061593616	0.374501644	8.175113958	2.96E-16	8.72E-15
GTCACTTCGCCA	2.715535677	0.000192989	EMC	Both of them	Random arrangement	DDWASSVLECVLSDAEDCTHGAPYSQCETQSHWAVGNHLAPPDMLECIIEEAPPLWAPMCSGGDEDLWGKALFGEWDFNNDNSST	800.2249121	3.469960705	0.614550253	5.646341673	1.64E-08	2.39E-07
													TTGACGATCTGT	2.733741002	0.000213069	EMC	Both of them	Random arrangement	AFSGADWDNLDEFLCTCHFNEGRDVADHAQADPLPEISEPTSTLVPLQFNMQEDNANPPPIYTFNAPDLMAFDFDLDDWICEQPL	660.1667638	4.998215248	0.894400445	5.58834164	2.29E-08	3.28E-07
AATGTTGCGTAA	3.48286852	0.000227314	EMC	xgb	Is known to be	DLMVYELGFPPEDDTPAPPMSGPETGPTPSNMDMEFEIPPISLYSDWDELMSAEVNDLLRLSPPSEQPTVDLYQESAPQYSPVSH	319.1642388	6.826853115	1.156354691	5.903770846	3.55E-09	5.43E-08
													TCATATTATGAA	1.418730781	0.000228602	EMC	Both of them	Random arrangement	PPRDGSDGEDINLLMENMEECMDWSTPLRFPNSWDVDEMDLPLQLDSYDPEGFDITPYPEAFASWEEEPPDSNGWDPQFHVWYPS	3940.766957	3.414590734	0.343544046	9.939309897	2.81E-23	1.58E-21
GCCGAGAATGAG	1.72190481	0.000237397	EMC	Both of them	Is known to be	IHPDAIDDWNQEETWNNVQPCSLEYDFDFDEFNTETTDFDDFLSLLLDNSPSKCHKPPELCGVFEIPENWRHGGYKAEGVDIPFD	2418.857757	3.123365755	0.393883679	7.929665333	2.20E-15	5.98E-14
													AGTCTCAGTCTT	1.477207925	0.000273402	EMC	cnn	Is known to be	SQARDGGAESDMMDAFDIIDLDWLGLLDDCTAPESHNMMFPDDDALMAEAGKVAANGATPHGEPYEMGPMMTLDVVLGSLDGLFA	7894.846016	3.066362091	0.379059676	8.089391425	6.00E-16	1.72E-14
AAGATGTGCAGT	1.39170327	0.000277108	EMC	cnn	Is known to be	LEFLDPTMHMCEYGDQPLLEIVLDDLPPHDIGTFSSWEDFVQDFFDSLGPLDDLGMSIDEPSNWISQSNSEETQNEDTEDPLMSF	6239.195896	3.363275966	0.402757658	8.350619539	6.79E-17	2.09E-15
													CTAATCTACCTC	1.419099967	0.000277108	EMC	xgb	Random arrangement	PIVGPMCSAFDCFCDAIYEMTFDDPATNHNSPARLPPMDESLLNPYECDWAEFLLEDTPCGCETMGWTCDNMLAHQENQPNQHDP	4740.187145	3.023531892	0.354129126	8.537936213	1.37E-17	4.48E-16
GGTCTGTTACTG	1.434289926	0.000278986	EMC	Both of them	Is known to be	AYAGLPIVSDEPGMDCIVPLSLAVRDTPEMMWSPPPPAYTAAANDSEIALMDQLPAMDEGLADEPLMDLDVVMWLDDLGFGPWEL	6126.177566	3.520280659	0.317773716	11.07794785	1.61E-28	1.30E-26
													AAGTTCTTATGG	1.676776333	0.000295765	EMC	Both of them	Is known to be	ETTCLPINPHDGDSVEETVTEILEPILSVGECVTLPPAPTTLSKDGTHEFLEDWGWPGIESIPPEWDDYNFVWSDVDQTLDFGYP	2831.870088	3.623003274	0.451763712	8.019686356	1.06E-15	2.97E-14
CCCGCACAATGT	1.866878787	0.000317008	EMC	Both of them	Is known to be	MEYTSPWNPAQWLETNVTLDDMWVRFPAHDEILEDFHLHMFADDNFEGDLFQDLLDVPSELWTWLDMEEETTIPLPWSPPESGSS	1203.799202	1.271448349	0.57433101	2.213790177	0.026843216	0.124915473
													TGCACTTGACCC	1.802452149	0.000395747	EMC	cnn	Is known to be	DCELYEGFPPYPAGFNVVPPEELTIDNDFDEFFASATEFDDFSFDHALMTAGATQDSSEKMCRDFQDIMEELDILDPEWTCIPFM	3445.792073	3.814494869	0.384168714	9.929217891	3.11E-23	1.73E-21
GGGGATAACCCT	2.120371842	0.000409673	EMC	Both of them	Random arrangement	PVPGFDMSPEQHGMEFPTTDFDFEWSEDTLWGWVTTPTGSETSFWSQPDCLFDFWSLCGQPNPETMPELPDHAVSDPQQESNDMD	4102.657829	3.716203078	0.572892902	6.486732621	8.77E-11	1.60E-09
													TACCAAACTCTA	1.502655786	0.000426879	EMC	xgb	Is known to be	AQEPADTPNHAFLPETSDLLPLMPDPWFPAWAPGSSPLMSLEQLMESWDDLELMDADFATSTGMHMSPSESGPSEAKNGEHGATT	1991.060262	4.487862313	0.566069867	7.928106708	2.23E-15	6.03E-14
AGAGTATCGGTT	1.885417237	0.000459126	EMC	Both of them	Random arrangement	MNEGDREDPDEFAQIVGGSLDNTLDVDLFQHYIQSLLWPGNGDPLDPTPPTESPLFPPMYEPWVQYDFQPFSEYDAPELEGNFDP	1367.410173	2.979034115	0.415636024	7.167410763	7.64E-13	1.68E-11
													GCAACGAAGGGG	2.119319042	0.000466378	EMC	xgb	Is known to be	QAAPLPQIPFLENLDQPEAPQGLPLGAFPSMAPSTMEDACDYTSEGSGPNLCDLSELLGGPFWEADDEKEGMFEDFLPLHLGSTG	619.2735377	0.916067626	1.187632465	0.771339327	0.440505828	0.724816362
CCAGAGCGGTAC	1.510895283	0.00047889	EMC	xgb	Random arrangement	IYKPQETDPTQESYIFYNQDTSSWTEPFIDGFIPQDSNAHDLGGFMLDMMPALTSDMSRDEWEFPIWLDPLAPQNMHHEWEFFDW	2666.07127	1.337007681	0.377750236	3.539396022	0.000401044	0.003231826
													CTCAGTCGGCCT	1.504905037	0.000490978	EMC	cnn	Is known to be	CQNDIASQFNLMDNVTLWNEDPPHSAQALWGSPMNESLMTPEMFWELLCDDFAYAATPEDQTMENSYASPGDPLDWFAHLETWDG	5633.585021	3.026941935	0.316033973	9.57790047	9.90E-22	4.91E-20
GCCCACCGAACA	2.138085549	0.000490978	EMC	cnn	Is known to be	RPNDPPQQMQMPIDEQNEDPNVEDCACNPMHDDGLTVDFRFDLYGANLPNEDLVPPPLGLPLTDLEWNEEFLVDLVDFLGEGNLS	2086.0966	2.48479893	0.459097767	5.412352459	6.22E-08	8.33E-07
													CAAGCATGGCAC	1.42269117	0.000565062	EMC	Both of them	Is known to be	GIGGSGGGGSGGVDALDDFDLEYVFDMDLYCEASEMISMHDLFGSDVDGFETEANLEAFYGNFCYEPTNHAGDPIDPMCHGWTSQ	5017.966702	2.475926883	0.240420651	10.29831205	7.17E-25	4.94E-23
TCGTAAATATGC	1.74202649	0.000565062	EMC	Both of them	Random arrangement	TQWCMYPPDENQIQPMLANEEHGQPHDDSSADVARQPCVLKTAWEGAMCLDETLEDLDLADFDLAIDTWACDAPITYDFSVNSPW	6447.832416	3.459934707	0.702778742	4.923220497	8.51E-07	1.00E-05
													CGGTTGGGGCCG	1.503441525	0.00057571	EMC	xgb	Is known to be	DGPYMPTPQSSGTLSKLWADEDYDADQPMPPPHDDYIVWESVPPGLELPGLNDLWMDELFFDASDFDWPSAALDVDDFDKLWFEH	2682.021982	2.486479024	0.4228392	5.8804364	4.09E-09	6.24E-08
ACGACGGTGTTC	1.651797702	0.000648535	EMC	xgb	Is known to be	MAENSAYWPQIEGLDEQCFFNDTALEGDGDLPALSFLSMPEGLPSDFPPTFNTPEILDTFLNAWPSFTWSDCLDDQPWPDTGDGE	2779.909388	3.628263174	0.612072176	5.927835497	3.07E-09	4.74E-08
													TTGTTCACACCG	1.989658257	0.00065162	EMC	Both of them	Random arrangement	DWSGFSPFDEYSDWFIGIAEDDHGSPQVDWDTPTAMPTYVAPHSPDTQFDMDTQQADNWPPHWNVDFDYMLHAYGMGTTFPQLED	1736.332111	3.719430371	0.507150421	7.333978675	2.23E-13	5.08E-12
CTTTGGTTGTTC	1.633864723	0.000655269	EMC	cnn	Is known to be	SNVMPLHDDFDITDISVECPGIHDTFLTTESGDTFWSAPEFSEFSTNILSLEDPYLDSLDLASPDLEPYWPGALIQQDEGMIDIV	2571.101089	2.493925143	0.350193898	7.121555108	1.07E-12	2.29E-11
													CTACTCCAACCA	1.30030528	0.000686799	EMC	Both of them	Is known to be	YPQDVGEAEADSVIDFQLGDCSEHWGFALPGPPPAPQHALLSYNGQNQIELDELLRQMFDYPDVNLLEEPIPPNLCCNSLLDTDL	5832.442028	2.516945674	0.300200075	8.384227335	5.11E-17	1.59E-15
CAAGTTCCACCG	1.336712612	0.000688962	EMC	Both of them	Is known to be	QAAQEAAGPGTDAVEQWHEEPCDLGPFASLDDPNMGPGGVQMEPLWQTPGLDDDMEQWLGPIGTYCPEQADLMLGGLDEISISDW	4934.087442	3.229188743	0.353813818	9.126802231	7.06E-20	2.94E-18
													AGTTCCGTATCA	1.550650617	0.000869141	EMC	xgb	Is known to be	ASMPPTPEAQGPQLFEDLAVYGQSDERALLDQLHTLLSNTDGEGPKTCTHALEFGRELTGMQSCQSDDGWWDPDIMLGLDFGQED	5861.186403	2.782148754	0.590510007	4.711433708	2.46E-06	2.73E-05
CTACCTTTCGGT	1.219762145	0.000892994	EMC	cnn	Random arrangement	ERTPGFPHTPLPEELDVDCWHEYVPEGFPQGHHAANQPFFHPLAEENYTDMDNCNMGLDFWGESLQHIEPEFWSISPWDFNDDEI	6334.314357	2.726797074	0.367868446	7.412424479	1.24E-13	2.91E-12
													AGATTCGCTCAT	1.303123863	0.00091372	EMC	Both of them	Random arrangement	SQPQVTAPHDFSPQIMPLPWWAPSFEQIMGPEPHLDMTPPSEATFFTTTMGDPHDQENWYRELTLEVSNWASMNLDDLDAAFLDD	4713.944467	2.653912881	0.294047414	9.025458993	1.79E-19	6.93E-18
ATGCTAATATAT	1.619607505	0.00091372	EMC	xgb	Is known to be	GPDEDISDGQLIPGDPVAMIQPMDGTLEHWGLDLDTSMGSLSFDLHSPAEEDIFGAWGLGGGLDNPISTQDCDGTGPWGGPWQQQ	2786.63416	4.251761789	0.444024869	9.575503735	1.01E-21	4.97E-20
													TTGGTGCTCCTA	1.74395297	0.000950712	EMC	cnn	Is known to be	FSNSNLQIPDWAFETCNDNYVWEQSYFPDPLGLPSTLSALPGETLLEWEELVLTPEPAHSSFYWEGHTSGTGAGIGGGEGPVDQA	904.9740884	2.478949843	0.610761835	4.058783147	4.93E-05	0.000470144
GGCTTGTTTCTA	1.441193887	0.000997992	EMC	xgb	Is known to be	YTPPHGQWMDLDYFFAGLPETETFFDFLEPQEASEEISISSQSIDELMGNDVFFAQPGCDPDVDPYPFNLDMGPVVSDHGGSSAQ	4417.208309	2.9152646	0.377686778	7.718736177	1.17E-14	2.90E-13
													GAGTGAGCGTCT	1.855284054	0.001058625	EMC	cnn	Is known to be	FDWHSQNAMSWEPGQNDNALFAPWPSNDNLPPPEYGLIYPSPIAQLDELLSHDVPMPADKLAELADVYNFGQDDLVGVEDLFMFM	1244.189074	3.052705039	0.681592887	4.47878066	7.51E-06	7.85E-05
TGGGTTGCCATG	1.317004679	0.0010876	EMC	xgb	Is known to be	DVYNTWPAASCQESIKPIPPESSPGLVYDFDSVFNSFEDNFQDFFNSLECLTEFMHDAGPSATGCRIGPTDGGGGVFSTTGDWHD	4389.204355	2.63183759	0.265199015	9.924009679	3.27E-23	1.80E-21
													CTACCCGGGATG	1.362642782	0.001090398	EMC	xgb	Is known to be	PPNVNHAVVVHANTFNDVYDVCETAPEPFHPIPPMFDAFQDLLGMNLDDCMSLVPEFDQLPLTPSAVMDSFHDETHGDVLWESIG	2978.579574	2.472216011	0.479772405	5.152893305	2.56E-07	3.19E-06
GGTACGCTCGGC	1.264249642	0.001090398	MH	cnn	Random arrangement	KTAPEGTEFTIPHPQEVEAEQCFVQPHVRDPWTPSLETKNADKDTEFMTCISTEPSMDQITNPLEDVQDDDMFYHWMDAWCDNVF	6523.173616	3.04025623	0.361593197	8.40794644	4.17E-17	1.32E-15
													GGTATATGTATC	1.326587566	0.001118002	MH	xgb	Random arrangement	HQPCWVGDGNCPETPPAPLMMGGDVDMEPLWDGDFEPFSFDEPCTWEPSNIIMELDELPFTHWDNDNNCFKPCVNWEFFAEFNNE	5531.146059	1.872695943	0.277018218	6.760190567	1.38E-11	2.73E-10
CCCACAATAAAT	1.637315472	0.001169298	EMC	Both of them	Is known to be	MDAAEFPLAGTSSCNPDNCDGLCHQEYHQSDETPPFVERPSDDMESIILTDLMDVDDMDFTAFPDGLDYIADGDWGLWVVPGFFE	2446.155676	3.657706453	0.552620774	6.61883633	3.62E-11	6.80E-10
													GATCCCAGCTAC	1.445186936	0.001198058	EMC	xgb	Is known to be	HETITVSSISMEGPSGDSLTAEDDSDYAPMPSFLIGGHTEYPTLFGDDDHAPWAEMRVCASLDAMDFADPQLFMDWLAIPDFGSE	2958.860308	2.190439493	0.368914943	5.937519022	2.89E-09	4.48E-08
AGTGAAGAAGGG	1.408072357	0.001247189	EMC	Both of them	Is known to be	GCITPWLSPRPAEVEWPEIPFSEEFILDILGQPHPPTPFGTPSLHDLYMVEFDTPVNDPNTSSIDDDHLELLGMKMNGGAGGQSG	1748.61217	1.694311602	0.452706958	3.742623284	0.000182109	0.001580618
													ACGTCATCATTT	1.660448128	0.00133078	MH	cnn	Random arrangement	WDFDWVGDSIMDIIPIEDMFDEVAPRNSCATWLAETCALSNIDTETLLDMTAGEDLCPSNDAGILSNLDEMEANTVWQWPPYQDE	2184.165608	3.474992893	0.53955168	6.440519084	1.19E-10	2.13E-09
AGGGCTCCCCCT	1.722086381	0.001460876	EMC	Both of them	Is known to be	DWCTLINMSPTPFYDGPNLVEDYGSLQDPEETYQTPFWPEVLSGDFTEESLEDLALMGMPAMPNLDCLQDVDCEQPDWGDLGELP	1540.276386	2.902239373	0.629138427	4.613037841	3.97E-06	4.28E-05
													TCCCGTTTTTAT	1.232146978	0.001460876	EMC	cnn	Is known to be	GRGVSTCCSIIPGLYDETTNHWADVLMAPLNALDDFDLDFLSALPSVDSMEPQSWSDLLDLDLMAWIGSMDPPECGRPADEKTSQ	4825.288799	4.241293911	0.325477294	13.03099782	8.15E-39	1.55E-36
CCGCGTAATATC	1.455545343	0.00157129	EMC	Both of them	Is known to be	DWEAHCFERFPPPPFNAMWDHGDVQPNPEPTDPSADLDGFDLTSLDCMLHDSIWDTPMIEFMNELEPGNRENPTCALGYEHTHKM	3828.059483	2.756195775	0.396552221	6.950398027	3.64E-12	7.52E-11
													TATAATGGGAGG	1.794749727	0.001609759	EMC	cnn	Is known to be	DHFLAAFVQPEPNEYIPIDDGGQFVDDPPPPEPLSFATGGPWNIDEFISSDVFNLEHFLAEGGSPWMMPDCALMDDDLTDLSDHR	1799.28851	3.524148519	0.49650177	7.09795762	1.27E-12	2.70E-11
GTGTCCCCATTC	1.286267461	0.001655036	EMC	Both of them	Is known to be	LSHAPTMDEMPSIGTVMFDDAVEEPGSHCTDMEYDLMGLLSILLEESSEPMSQLGLFTGGTTINPLAQLDEYLMSTLENDASPGN	7877.4285	3.853848837	0.275004971	14.01374243	1.28E-44	3.98E-42
													TCCCTGCCTCCT	1.134230603	0.001704887	EMC	xgb	Is known to be	PEEFPWWSSFEPLELEVPEIDDVTLPWPMTNLGVSTIFPQDVYLTDLHFMLDLMGNTDHGPEMDTAMDAMCDQDVQEPDGWPATP	5860.41339	2.175256706	0.406465964	5.351633096	8.72E-08	1.16E-06
TTGTACGATTTT	1.244252005	0.0017694	EMC	Both of them	Is known to be	PTNPSSNPGAHIIATGSEWLDWSWGDNMGDPLEHGPTPCGTPSLIDLWGMEYDVPTHDNSEGFCNDLFGVPDDFWQQQFQWCQEY	5501.425104	3.013968307	0.298245098	10.10567592	5.21E-24	3.23E-22
													CTTATTTTACCC	1.463490911	0.001776126	EMC	cnn	Is known to be	GQMIIDTWDVPSLDSPNIPLLQFEDLGTLDEFLAWGPCMLNDEFWTDLFMNDSYPALLGGGELDRDGNHMSGDICMHGGRHPGSD	2574.033948	2.860771614	0.316617747	9.035411453	1.63E-19	6.48E-18
GTAAATTTGCAG	1.630434296	0.001867301	EMC	xgb	Is known to be	GMTDSELSDEPALWGPGSQVSPPPPHFDAHDLMLDYQDLFDLDCLGRLGLDELDSNMLFSESGGGINWPGQHQVIDGCGEIGPSQ	2771.015608	3.505506205	0.568714626	6.163910769	7.10E-10	1.17E-08
													TAATCCTGTTCG	1.302654628	0.001867301	EMC	xgb	Random arrangement	EMWPFPEANDEESLVEFWPWRDPSPNEPFNPCNTDSFGDMCEALDLDPLPAYVCNMWNNDVDTDWNPDISLAPWVDAELEIDETF	3262.98615	3.331570329	0.27180499	12.25720813	1.54E-34	2.00E-32
TAATCTAAGCAT	1.587707452	0.001950146	EMC	cnn	Is known to be	VEWGSSSGGTWDPPHDWVDPIQHMWDCPPADLDGMFIERLFHDELWSDSLMPAPSNMMGYDFDAYEAEHGITDPWDPTDIGNDME	1914.479347	2.78681023	0.407975881	6.830821043	8.44E-12	1.70E-10
													CTTTAATTACGC	2.029869614	0.001982389	EMC	xgb	Is known to be	DDISMPGSHVDECNGDSVDSPTNPIPFDPDMANWETAIDDTSDEKLLDNLPSMSGTGPMWGLTLSNLQGEDICTWEEGLGHWCFE	1121.511367	3.82427212	0.438116358	8.728895991	2.57E-18	8.85E-17
GCAAAATATGGG	1.736157518	0.001982389	EMC	xgb	Is known to be	DTFCPTPSAMGPGLSEDLTPGCYQDALPMLDHILGCPAVSDLLGENPKDEGMGIFELLPESWNPSLEQVDLDGYLDTWELGGGEG	1695.491372	3.973423731	0.699716047	5.678623133	1.36E-08	1.99E-07
													GCCTCCGTTCTA	1.507270079	0.001997295	EMC	Both of them	Is known to be	TDDGLELDDFLQPIVYDFLAETNDFDAPPQDYGAGHMLDGSDLEMLTSLLDDCHFMGPWIDDAFCFMPSPEPQDMTQDDFALDRQ	5708.506798	3.721184199	0.365092137	10.19245233	2.14E-24	1.40E-22
AACTTGGGACGG	1.73431518	0.002083903	EMC	cnn	Is known to be	ENNAAPGHAQSPIAAVNPLDLPDPLGDHWFVWNNDSDAFWDILGEILSDIPSLGHNDMDNWFDSLAEQPSTPGHWTWHPEPPGFI	1566.681268	2.962139305	0.496217698	5.969435025	2.38E-09	3.72E-08
													AATCATTCCATT	1.284729673	0.002164959	EMC	xgb	Is known to be	EDDCYPPSHSQPPVDAVWVYGPQSAPIDENDEAVSDRADCNVWSPSPGPEGLGNILSELQSLDESGNFFTDMFQSDTWLDLPHML	4254.174998	3.190295875	0.395297121	8.070627657	6.99E-16	1.99E-14
GCGGGTCCGGCG	1.649396782	0.002283092	EMC	cnn	Is known to be	QESMDHVIGTPFGTPSPHEPYDPEIDVPEGDPWELAHCDLFHDIDLLADYMVSMIGDEQLASKGVNNHGWGMQGEACSWNNHEQQ	1724.105464	2.465605702	0.504149061	4.890628376	1.01E-06	1.18E-05
													TATTGCGAATGA	1.548101263	0.002321803	EMC	Both of them	Is known to be	SSAFPEPWTNLGLLEDLLPSEYWGFCKAESTAIQGSLLDTSEDFLAMLPELGDLGSLLYETAHQQVDAVPDEGADSTQGGGQDVH	2647.452879	2.562959965	0.380888505	6.728898179	1.71E-11	3.34E-10
CTATTATGTCCA	1.412306436	0.002332137	EMC	cnn	Is known to be	WEWFPLDPQAACPSDPNEHMEAQEHLTFQCDHTVPFCPFGTHSLHDLFDLDVDVPEMDNMLQEFWQDELAMDANDHDEQAAPAWE	2778.200845	3.144909607	0.563121841	5.584776467	2.34E-08	3.34E-07
													TGCCCTAACAAT	1.224292292	0.002382444	EMC	cnn	Is known to be	LPGEKRQKTDAPPPYIFFEEGPCHYNEPCWDMDLMSPDTVEWMMDIPDLSPAMAPMNHDMQEYWDELFPLFDIGDTECVGDLWDA	4231.105437	3.692277701	0.341528882	10.81102622	3.05E-27	2.36E-25
GAAGAACGGCTA	1.246884588	0.0025028	EMC	Both of them	Random arrangement	PSDVLQPAEEMFDDMLWCLPNEINEWWPHEPGWPMGGISPWHALHGENEDVNVEYLQIYEEDCATANMMDSTDVNQDMDIPQPQW	4302.908545	2.752842865	0.445219963	6.183107438	6.29E-10	1.05E-08
													TTATGTATGCAC	1.588943144	0.00263566	EMC	Both of them	Is known to be	DWRTDFYCVTDDIDIESVMSGLGLELAEFQACAWAASPPFQPVQECYPGRDMGEEFNLDAPLSDGNNWELDDLLNIDEFASLPDD	2552.337876	3.765321422	0.623288571	6.04105642	1.53E-09	2.45E-08
GACCTTATTCGA	1.906039541	0.002673618	EMC	Both of them	Is known to be	PDMNDSMGEACPPDTGPSILVPRPDTPDILGSPHPFFDPAIYGWSTMELFDPLFPELHEIGGLFEHGGSRDCTTYTEGGGRPGGD	1335.657405	1.900409962	0.440770727	4.311561189	1.62E-05	0.000163292
													TTCTTCGTGGCG	1.150708474	0.002673618	EMC	cnn	Is known to be	PDAGYSQVPMPPEGGEDHEYLEESPYMIPDYHYEGIYLDNFDNFAEDWFWPGIFDELLCVHGPPVGPMLPTTGNSFPPDIDGSQE	6191.365346	2.557105031	0.485264266	5.269510262	1.37E-07	1.77E-06
TGGCTCACATTT	1.204488061	0.00276662	EMC	Both of them	Is known to be	HVQGADRMWDIPEWLQGMTSEHWYVVDATEPMESSQPGPTWGGSELEDWDLGGLTSLLEMGEYEPAHSPIPDTWSLDSGYNFIGQ	5349.778951	2.679110586	0.398826814	6.717478589	1.85E-11	3.55E-10
													CCGAAAGAGTTT	1.228617297	0.002798046	EMC	xgb	Is known to be	TEDDSPSQSTIEPALQDILLHPIITLDDDCLQNMDHAPGDFLDPFDRVDALPPPDPDLLEFGKAWGQLDDLGILLPTTSMHWNYF	4123.557293	2.220291542	0.315595602	7.035242342	1.99E-12	4.18E-11
GAGTCGAACGCT	1.532353989	0.002854478	EMC	xgb	Is known to be	SPIGAPTLMFPDDDNCIEIANWCYSDLGGLPWFEPRTPFGTPSLQELIDMENDVEPPSQIAQACPDSCEGMDSNIMLEPSAWNSG	1424.123524	3.684632733	0.636383294	5.789958292	7.04E-09	1.05E-07
													TGTGATAATGTC	1.246102183	0.002854478	EMC	xgb	Is known to be	DDLEHLEGPCPPGTPEAPLPATYGRVADLWNNHSSTPSPWLLDFELNDFFLGSSPSAKETSEPVDFLPADYLPDFDLSPTMDETQ	8268.74593	3.752845527	0.272266356	13.78372848	3.19E-43	7.54E-41
ACTCAGACGCGT	1.976739229	0.002878942	MH	cnn	Random arrangement	SMMDVMDPIMDIVMGSSQGTGYSCDVYQHPQPPNPEVAPVTEPMELGNNPFSEAWVTATWDEEVHHWVNGLNDPCDFDMCHWWVD	2534.465185	4.745649309	0.52240857	9.084172001	1.04E-19	4.21E-18
													GAACCTAAAGCG	1.686149433	0.00325843	EMC	xgb	Is known to be	DDDVNRGPWYIPDMFQGGLEDLYHLGPPEPSWTSTESWLGDLFDVEVDGNAWGASQFAGDNWLPEEALLEAYCEDIESQFCRKIQ	1317.386009	2.547775373	0.353204212	7.213321046	5.46E-13	1.22E-11
CCTCCAACCCTG	1.319682614	0.003272352	EMC	xgb	Is known to be	DETTGGFDDMLIEPPISPVLLPTDSSCQLGDLLRPPTPITEDLLHNLFGLDVFPPESHYMLWDDFWVNDEFINRADPGGAKPFTG	2226.100627	2.619286117	0.42953265	6.097990734	1.07E-09	1.75E-08
													AGCATGGTGGGT	1.765289187	0.003450569	EMC	cnn	Random arrangement	GDQSPEALLPEGGDDPMWPVVSELCQPQTYHYETADVDLQPDMWISTTNIAKTVEGNEDATPMNFYQQEEDIIWAWLYDAMMCAC	1150.798879	1.987562997	0.55610087	3.574105174	0.000351428	0.002907639
AGGGAAAGATAA	2.141619099	0.003554675	MH	cnn	Random arrangement	EEDHVKYDIWSIQNAFHEIHNMSNTTGQGLVWWFHRHETGLWHLKLMACYIQAAYVKTSPDVWPFNQYGRPRADDINNFMCFIKG	255.1645377	0.304045755	1.297869855	0.234265211	0.814779092	0.924037799
													GCACACTGGCCA	1.343849325	0.003558755	EMC	Both of them	Is known to be	TMDDFMPDHINDPPKDYDAADPVLDNETLPWALDHCDLDDLWATIWTDVYTSQPNLSLSHLPADEETPNDTPGTWEMPLFAQSPM	3354.161338	3.404903166	0.373682889	9.111744914	8.11E-20	3.35E-18
GCACTGCTAAAA	1.512329133	0.003589647	EMC	xgb	Is known to be	YTPDTNMGPLMSAPGDDSSTSEHTGGRTCGGLVSGAKGMSRLHTAPPTLDLGDLFELLCETANPQGPMQSLDDFDLQGLLDGDVM	1781.676223	2.426119326	0.431084024	5.627949982	1.82E-08	2.64E-07
													ACTTTTCAAAAC	1.461221901	0.003660278	EMC	Both of them	Is known to be	ALLDDTQPPPLHSYALDGDYQGGHFPSAIDTFNSSVSSVGSEIDDWLLSDLGDLSELLFETACSEDWLESMYGGWGDVLPDQALL	3501.3409	3.362827872	0.378407854	8.886781375	6.29E-19	2.29E-17
CCCTTGTACTAC	1.461174459	0.00371128	EMC	Both of them	Random arrangement	AFDSQQGPHDQAGLSMHTGIPNDVLPDVWLEMIAETIGQGIQYPCHDSTEMYNLPSPEDISSNDGMCLEDWWDEIMGFTPDFFPY	3360.348742	3.298042181	0.405944387	8.124369457	4.50E-16	1.32E-14
													ACATCACTGCTG	1.173331243	0.003770324	EMC	xgb	Is known to be	FPNDPWDTSLPIDYDFDYFNAIEVPDPDFLKLDSPEMSSLDLFAVECDQWELDHNMNAVPRMFPEHPSLEAEEGSMAAPTTGCGT	4854.808818	2.126511412	0.347762163	6.114844111	9.67E-10	1.58E-08
CAGGTTAAGTCC	1.269971762	0.003770324	EMC	Both of them	Is known to be	PLLPQVPPPTPTDEGDELPLPGWDVIGDSADAHCVFELPMPGDIDQVFEDMLPCMSNPYGWLDEADFEFDIQEQMPPGVHFEGTL	6963.150138	4.046759523	0.463526082	8.730381481	2.54E-18	8.80E-17
													CGGTGTTGAGCA	1.302416984	0.004141148	EMC	Both of them	Is known to be	ADMIENLYAQECPAMGDIAEMYHWPTDQTPHPPGWEQYTDIYGLCYDVDLVPPSTSLGGMEPLPPDWECNLFELSSDWFEGTLSF	4013.140912	2.193734231	0.338695225	6.477015527	9.36E-11	1.69E-09
ATCTTCTCGGAA	1.543808173	0.004352367	EMC	xgb	Random arrangement	QMRGDDITDPFMFWGFADSNTLSPNPRRCLEQLTNPEPAPTWSYVSDGVEDEIAQFMDNLENCWHDWDDDANQPSVDPWSWLELP	4149.574481	3.965768031	0.371570289	10.67299553	1.36E-26	1.02E-24
													CGTATACCGAGG	1.29844132	0.00457581	MH	xgb	Random arrangement	DLSGHRTSDDLGEAQPHTWDSGWSSHACPCKLPFYDEEDGPEIPAISALDTSLENVSNHEEDWSTLMEFFFPDMTCVMEDNRPFF	1813.184248	1.792415644	0.382942754	4.680636011	2.86E-06	3.15E-05
GGCGCAATCACA	1.440425115	0.004903342	EMC	xgb	Is known to be	EMAGQSPETSVALEEEVGGLWPEQSNVPPPIGNNLTLSDLDSYVDQDLKEGLENELEFPVAPFFMEDIFTWASEGQIQPLPSMDM	3233.922268	2.461643172	0.457322217	5.382732524	7.34E-08	9.77E-07
													GGAGAGGGTGGC	1.421472392	0.005156555	MH	xgb	Random arrangement	NEAHGNCLDNAMQRFNDAFECFDVTDHAEPWRSENEMTHPFFSEDYFLGLDFNDLPFTCDYEDWEPIEECVCQGWMDPCAFTPDI	3505.860882	2.614001898	0.477582329	5.473405814	4.41E-08	6.09E-07
CGCGAACTGTCT	1.835221808	0.005225627	EMC	xgb	Is known to be	NHDFDFNLNAWADIPDLNTVLPIWELDDAAVESFFFSSEDSTPMTEGYSKQTKHTFPPIQGTDDPYWGENMQTVTFIGGTWPPCC	647.5695441	0.545441354	0.510447068	1.06855615	0.285269716	0.591634761
													AAAACAATGGAT	1.940511594	0.005698395	EMC	Both of them	Random arrangement	VVENSIQSVHWSSDEFITWLFDTDLTEVTPAVATWELPVEEPGMDLPDWTPWPMLFPNPSEEGTWNMADLPHDQLFDMCDQDLWT	1046.096028	3.521284875	0.526185506	6.692097814	2.20E-11	4.19E-10
CGGAGGCGTATT	1.422296081	0.005919641	EMC	xgb	Is known to be	WGDGCDSSNPMDLSPPLMDEHFSEDEIFPRDWDLDSFGLLDLPDLDIPEEAELMDARLSFLMSGGLGKNYEGPGVDLSLGSELAQ	2231.260098	2.725057627	0.643826717	4.232594816	2.31E-05	0.00022716
													CAGACACGTCCA	1.48070294	0.006047264	EMC	Both of them	Is known to be	TQDLCPTGADPIDIFEDIFATQTLDFDDALQLGIEGLLDLPMDDMWPSETGLVYLDELLRQYNLMEAKESPIAPHDNVSLYPGEQ	1781.602821	2.746020568	0.488359506	5.622948944	1.88E-08	2.71E-07
CAGCGCGGGCGG	1.317076394	0.006047264	MH	Both of them	Random arrangement	QFDDPAFDELWNAPPSLPPEYVNETMPDFLHQESGSIFAPCELTMPSLGEMLLILDIDSQENMEGFEFFMQPNIEESNIHTLGGE	1700.870041	0.991302797	0.466369804	2.125572428	0.033538877	0.148941466
													CATCGCTGTCTG	1.262909244	0.006047264	EMC	xgb	Is known to be	WQGLLPPSHLEPPTLLEDGLTYEVEALDQMLHDCNTLSPSQLMPPAAPAQPVYGVIPLGQLSVLPIGPTIDIDSWEEFLQNILST	3595.947332	1.36125473	0.339416598	4.010572073	6.06E-05	0.000567474
TTTCGCGCTGCC	1.155383569	0.006487806	EMC	xgb	Is known to be	NQPDNAGNYVMDDLDLFMGLNLFPQKIIPDIGDVEFLWAPAQCLPDPSALDDSDLDLLDGQAIPSSSQSWGLSFDVTEHTETDRF	4113.187327	2.142200878	0.326803932	6.555003374	5.56E-11	1.03E-09
													CGTAAGCCGCGA	1.634662914	0.006959411	EMC	cnn	Is known to be	DLDGNYFHSSPTGMWWDDFFNEMPVMELPVNCTSNELAIDPDGLEDLDMLGMIPELYSFIASLDNFDPAQQASDVVYEEGGHSGM	2505.988677	4.174856174	0.332854988	12.54256757	4.37E-36	6.76E-34
ATCTGTAAAGTC	1.062295811	0.007347236	EMC	Both of them	Random arrangement	PWAHAQHDDLMDWLMEYFDHDATNFEPVPRTQDQWQPQCFSTADTDLSIYLYDDIMPNVDWELVPCTSADQDWCWNQVTPQPGDK	4881.246364	2.857218788	0.300596523	9.505162465	2.00E-21	9.34E-20
													GTTAAGGTGGCT	1.286083245	0.007493775	EMC	Both of them	Is known to be	DNTDSPLNLTYTDMEPWQPDEEAFAWGSNHALPHELVDFDLDITNLDFEEGGLAYYLAATNMSFWDFEFEDWYFNAHGMDMDFLE	2094.349913	0.662534342	0.508036787	1.304107023	0.192197095	0.479060318
CGCCGCGCCGGT	-0.898915683	0.007570357	EMC	xgb	Random arrangement	FLKAETPTESQISMCVGTDPTVHASIMQPILGDEPHPTPTMGEEGPPLMSPWTEDDPFNFWEVADTRIWDVLTFPDMSSAEEWWQ	2731.62001	1.845110367	0.517288742	3.566886761	0.000361247	0.002983904
													GGGGCCACACCG	1.091984689	0.007570357	EMC	Both of them	Random arrangement	LEQADRAPNALIEGLEDFESDHCIQDTPDFCFTSTPDITQDTMYPWIYDPYLGPGFMEEFVYDMNPPEMLSIIADTCQEGPSTNH	5014.363267	3.127441422	0.303043449	10.32010899	5.72E-25	3.99E-23
CCCTCTTTCACT	1.457688916	0.008218771	EMC	cnn	Is known to be	SWYEIHVHPDMAISAPPQTSPREVNEQRSDNYEPDPLEPFYLPWPEESNDLAEDMLGALNFPEIECFDWDEQLRSNDIDSCGGHY	2360.424338	3.20525403	0.469733778	6.823554491	8.88E-12	1.77E-10
													CGCGTATCTACT	1.160156084	0.008223658	EMC	Both of them	Random arrangement	SEGPTSPYVMGTPSAAEGAHPEIGNAMTQPAQWDCQCQLFEYIDANNMCHEAPEGLLCAFGFEDLNDWINETGEGLEWLLGDFTY	1995.254972	2.394469569	0.467982874	5.116575203	3.11E-07	3.83E-06
ACCACACCCAGG	1.613777206	0.008224683	EMC	xgb	Is known to be	VDTDLLAQAMTELSQTVSQIPPPPDLPCDGCMSEALDDFDLTLLGDDEHWDGLDMFAALFSAVNEHGKCAHMETPVWDFPSMISW	2476.992259	3.434909034	0.535244183	6.417461682	1.39E-10	2.46E-09
													AGGTCTGGTGCG	1.376487762	0.008224683	EMC	xgb	Random arrangement	DGPTTYYVLPQVPIPFEVSQEEFRCYFEMMPDPSPAQDNAFGSWMYQSDDWYEDFMQQPTSNDLDTEVSDWVDFDPNTTNSEALG	2166.794323	1.631106474	0.490490617	3.325459073	0.000882731	0.006598511
TCACAGGACCAC	1.199366681	0.008358218	EMC	xgb	Random arrangement	SPTHPIFGPTPAFEEWSPECLGAAHHDVWWQCFDYTPDHDITQSLPQNNWDVNLEMFIQHGDPEMYGGIEMYEELVHGDTPESQP	4798.552063	2.538892681	0.40786765	6.22479542	4.82E-10	8.16E-09
													ATTCGGCGAAGA	1.511099946	0.008364826	EMC	cnn	Is known to be	ETENDVEVYVANHHGGIFEPEQEFNCADMPSDFPPETPRTMSIVGQELLDLGSLAEWSWDMLDGSPDYDQEWEILLGWGDKFMLH	755.1836636	1.49274664	0.458604844	3.254973559	0.001134029	0.008277244
GACTGGACCCTC	1.132555122	0.00867817	EMC	cnn	Is known to be	TDDTPANEPDMWWISIIDGPLPMEPQQTVQNDMSSAGPVAEDLFETLHSRDVWNVGPDTYLNDECLLQMGGDPEYGGIGDGFLFN	4549.676459	3.251758007	0.672777854	4.833330928	1.34E-06	1.55E-05
													CCGGCATATCTA	1.116149854	0.009227394	EMC	xgb	Is known to be	HRFTTPSPSPSILHNTPEQTVGEGLGFKPTTENSEALDAGSISEDISDELMSSHDAAAYEWFDWEENHEIGMFLDMLVNPHYGIN	5383.287568	2.870743615	0.414198361	6.930842521	4.18E-12	8.60E-11
GCGCAGTCTAAA	1.495654888	0.00932812	MH	xgb	Random arrangement	NAMPLDCNTDMGDGETLNINLPSHWCPHHGVDRNAGWATSESAHLDMEDFFPDMWFENVYAFAPIQPVSDQDSINTGLDDFMADM	1541.676253	3.194100626	0.655018431	4.876352291	1.08E-06	1.26E-05
													GCAATGGCCTCA	1.446920494	0.009397213	EMC	Both of them	Is known to be	KELDDFEMDMEDFLPGELHDLMFTHFWAEDTVWLDMLESSAFPDFDLDMLGAQLPMPEDAGNLHAPDSKTNMIDSWSELWALSDD	1538.96417	2.251471792	0.389483721	5.780656978	7.44E-09	1.10E-07
GTGCGCGTGGTA	1.559194847	0.009397213	EMC	xgb	Is known to be	DPMCLTTNCYTDLSAIQQELPPQWQECDDLDDLMTWLSNSDAELGLEDAMRFSPLELWGQVALSDFGGDLFDGWGGFGDMYTPTV	817.4336439	4.178843929	1.256175204	3.326640994	0.000878995	0.006580515
													AGTCGAAGCGTT	1.103969493	0.009428423	EMC	Both of them	Random arrangement	PDEPTQDPGDSWFQPLDWDLVDLEYETGPYEPPLNLEDQGYHIFDSVMDEPMSQWWMDWDSWLLSGDQHPQLPWFVNENAAGIDF	4397.397595	3.71074156	0.299490372	12.3901865	2.95E-35	4.07E-33
AGACCAGCTCTG	0.991622136	0.009542547	EMC	xgb	Is known to be	GGRTEPAPDLASSLEDILFADQSPSDEGALLDQLTCALKDDPAESLTDMALNGEDGEPEITLWDCEPFDEWGELAMLEQGCPNSP	7303.747895	2.654345163	0.266860345	9.946570212	2.61E-23	1.49E-21
													AGGCCACTCGCG	1.623772181	0.010031693	EMC	Both of them	Random arrangement	SPQEGAGPQCSHGPPLDSQQVADEFAPEALVSPCTWSNNDQIWLEEICNDQFPIDDEWILNLINPIWAFDLHAGVTEAEATDFHI	1845.41485	2.05634695	0.390007419	5.27258419	1.35E-07	1.75E-06
AGGTGGAAGTCT	1.319977899	0.010245278	EMC	xgb	Random arrangement	GTRSSDEQGQIPEDASWALGLADEMGSEFNIFVPPELPDFGAQWDDLDFGEIFNDPWEMYSYIRDFQLSPSALPHHPNYAPTHDA	3328.013173	2.46247093	0.376661471	6.537623618	6.25E-11	1.15E-09
													CATTTGCACCAT	0.955280449	0.01030946	EMC	xgb	Random arrangement	DQDKDMYSTLMDDPWIFTSHDVELDSYDDFLSEWIWEGGTYWSFAEYSNWQDPANLTAPEQHPDNVQSGIGSQPEQPASHPFYES	6966.796334	2.641627687	0.314227942	8.406724338	4.22E-17	1.32E-15
CTAAGCACTCAT	1.312414234	0.010348854	EMC	cnn	Is known to be	DLYDFDGIFDNIQMIIDDGDMWRPDVDPSWTPPEPLSDFDWTLLNDPAVQLPLMDPLNGLEWHQSIPSEEVFMSKIEDSNFAHDC	2433.562117	3.406892806	0.349764604	9.740530545	2.02E-22	1.06E-20
													TGTGGGCCACGT	1.686825599	0.010559774	EMC	Both of them	Random arrangement	DDDKNEFLHWLPLTDPWDLELECMCEYGAPFPPCQPTLHATQDIEDSQNMSTELCWELEQWAESSIDSFDFPAEALPDIHDAWPQ	559.5695347	2.949918542	0.878382711	3.358352238	0.000784086	0.00593272
ACAAAATTACGT	1.184821088	0.010584388	EMC	Both of them	Is known to be	SMPPHANGDLICPPEQQWEELQEWFNRDWCLPPLEDPVEHQLSEFSMSEQTLPGLPDDLLLYELVHQFEAIFDDMSYDPVGPMGI	1992.18041	2.155853461	0.559520605	3.85303676	0.000116662	0.001045527
													CGTGCTCTATCA	1.127125893	0.010721594	EMC	xgb	Is known to be	RTPPHPQGPTCELPGEPMDLEPQSDGNMHVSSACDIRDLMDGLGIIDELMSTDGQCSSYLALDCPWWEDDPMFTDPLGQMHLGGW	5226.732262	2.780390902	0.470311197	5.911810994	3.38E-09	5.19E-08
GCCTTGCTTTCT	1.12558143	0.011302143	EMC	cnn	Is known to be	CAQQNNPIPAIYHQLLDEVSDVANFNFDSLGWWTTPFSPHSTDWAQQMEPLEDFDMATLNTCDLDLFDADYGEIWTDDPMWTEAP	8941.401463	3.087946956	0.407783307	7.57251928	3.66E-14	8.85E-13
													CTGAGGTCGGAA	1.561730326	0.011365282	EMC	Both of them	Random arrangement	PYAVDAMIQPGFPGPIPYDLEPPADWDNVAWMEEHINPSYCADLFLPTDDLLPYLQREDVEAAIWEPFFHNLAPNQDMDQDAPYN	1527.503273	3.681994527	0.475663506	7.740754713	9.88E-15	2.49E-13
AGCTCACACACA	1.129649873	0.011895446	EMC	Both of them	Is known to be	AQDDDSEDDHAEWDICHVELNAQAAAADLVSPVMQGDHPELNAEDLYWCFPELNEAWMNFLNDEFLTADPTNVINPEGTYSQVQH	3705.125677	3.467448825	0.442140503	7.842413889	4.42E-15	1.16E-13
													CCCTCGGTACGA	1.455891879	0.011902135	EMC	xgb	Is known to be	DITSTEQDSSTPEATGPILFEDLAVYANQSSEDNNCNPFYDLSPDGPWESMSLDKFMMARDSPTPAIDLSLESRMLWDIMDVFDP	1923.241584	2.927257661	0.564200771	5.188326231	2.12E-07	2.70E-06
ATTTCCATACCC	1.760869546	0.01251167	EMC	Both of them	Random arrangement	YEGFSTIHMDLWQTNVDHPCTLPDVPAAPMHCEDPDTWMCGLEPLFEDMFMDMDIDFANWDDWALEPINNLGATRDEHPGASTKV	1522.492942	3.027641	0.351975036	8.601862896	7.84E-18	2.63E-16
													TTGTCGCCGGAC	1.034022901	0.01251167	EMC	cnn	Is known to be	TSMRQSQIMTDVHNGQTLLNECDFSAPWHIDLDLMGPSIADWSFDDPDLDILWSFGMMEDVPQVSTACNNDEECIPDWGTTQSAQ	9108.758479	2.951815292	0.377409972	7.8212435	5.23E-15	1.36E-13
AACGCTATGCGG	1.327310863	0.012969679	MH	xgb	Random arrangement	LEACAGCQAETQGENWADMFSSYADTPWEPDLLPTWDGADLNNELLWTEPWTMPVDGLNAVPMFRQAEYPHHWDPMAESPEWQTP	2037.900043	2.701353121	0.619738172	4.358861922	1.31E-05	0.000132505
													TATTTCCCTGGT	1.322184296	0.012969679	EMC	Both of them	Is known to be	DMLRPGTHTSMQDGDPAGQPPALPHCVDPPSNASEWMSLHDFAFGENMAGEDINPMTMPLGDVLELLETWMPLSSWNWHLDEPNL	1711.6467	3.181158609	0.607952337	5.232578967	1.67E-07	2.14E-06
TCTCGCCCACCT	1.717018958	0.013411334	EMC	xgb	Is known to be	FDDWDEAMTPRSGAFDLFNQLSPEDWSLQISCPLEDSLTVMGELGDLFGVLEQDFPLEHPYCGLLGGEASSEPPGGDGGSGLQLQ	538.2960854	2.329368416	0.607016958	3.837402536	0.000124343	0.001106359
													CAGACTGTCATC	1.139557704	0.013635021	EMC	cnn	Is known to be	PGVNMRPMQGEAFELSDDFKMLEAGAFAPPLSPDICTPWGTGSWTEPSDDTVSGWAGLTSEDLYMADPDWLDNLDWGEPLGWVCK	7046.966194	3.031625654	0.302325495	10.02768772	1.15E-23	7.05E-22
ATACTACATGCG	1.476860182	0.013671917	EMC	xgb	Is known to be	FDHFWDITLPPAANDPPSHCSETTGPQDFPDLLTDPTMSHQGMFIQELPDWRDLAELLGETTSPLMPGTPLGMLNGDGENDFSCY	2010.419948	3.874257573	0.430567494	8.998026166	2.30E-19	8.76E-18
													AAGATGCTGAAC	1.576052933	0.015004589	EMC	xgb	Is known to be	HSILDQNAPDGSCPNTMLEFDSPPGEGSGPELDMDIFMHDNWDSVEDIWHPWWEVALNEDFAGTLALPPIPDGLAATPWGTSPNW	514.1384993	2.31695255	0.793004123	2.921740863	0.00348081	0.022728452
GATTAATAAGTT	1.11822062	0.01625888	EMC	xgb	Is known to be	TSQEYLGSMEDVCENPGLPDTYFDLARFDLDFPRTPTPGILDSWIEDIWGGSDPMMTPPLLPNRDFTNSTVEYLAFCFNTLGSSE	2584.262615	1.41448368	0.434855651	3.252766009	0.001142876	0.00830512
													GAACCTAATAAT	1.410626294	0.016324156	EMC	cnn	Is known to be	TETGSRGSSSPDDSLDLLPEAEWLSEWCPFDDQLNFWEALDMDMESLIYNDLSPGLVLDFIDDNWGGPALGGIDSGYEDDAGTSS	1416.381787	3.90487506	0.4323414	9.031924914	1.69E-19	6.58E-18
TCGCTGACATTG	1.123269509	0.016768555	EMC	xgb	Is known to be	SDGPVIHQPGTTMLNEMDEHLNLWPQLQLEQCDLFWDNPFYEHPDLNAEDPWEPLTFDMADNSEMESLLAHACNEWDMPFQWNTP	5032.918063	3.233806936	0.336175534	9.619400021	6.62E-22	3.35E-20
													CATTCCAGATAA	1.012571839	0.01711985	EMC	cnn	Is known to be	QPSWGELPLGMPINEWFQTENDQLFDPLLDWSPMSETGSGLCGLSKQGTFDEGLADLLRDALDGYCVGDGSKQQGSCIDLGGGGV	2986.106351	2.007973984	0.407299056	4.929974554	8.22E-07	9.75E-06
GTCTTAATTTAA	1.257984957	0.01711985	EMC	xgb	Random arrangement	WPDPPDDANINYGLTFQHPNCLEANFGLDIIEDTDPQVPILDEGISQRWLNDLNSIDELDIMQCMYDCYAPAEPEMQPMSQDDCP	2264.313462	2.667781721	0.414199267	6.440817104	1.19E-10	2.13E-09
													TCGGCGTTAACT	1.003143771	0.01711985	EMC	Both of them	Is known to be	ADPGTSDHGGPDALDTASMWESCLHPWDVMDTPSMWPFPCDVLSDPEVQSAWEDPLWEEQQETFPYFSGAEAWETSYACGSHGGI	1760.343596	1.646696854	0.484712842	3.397262691	0.000680636	0.005246084
TTCTACGTCCAC	1.428007407	0.01711985	EMC	Both of them	Is known to be	SPIEDTGDGTREGSISQAADCGGINLGTLDLGGSPGLSSDLYDVLDSDLYHDPDFCGGNGRPGWDEGSDLSYQMFELLGMPPSPF	3241.759604	2.301850716	0.61535669	3.740677159	0.000183525	0.001590123
													AATGGGTTTGCT	1.149943774	0.017290882	EMC	Both of them	Random arrangement	QAFVDTMDGPMEWPMICVEPMPDVDPWIECSAPATDLSWETFMVDLPQMSHNLMNDLENMELTFHPTPLGTSAWSSSKRSEENEP	1845.309149	1.610641127	0.557907956	2.886929841	0.00389021	0.025038804
TGAACGCACTTG	1.137142632	0.017314827	EMC	Both of them	Is known to be	LLGGDSMLEGLPDFCVFPEFEESELFAPDLMNYQFATPHSEPWTWEITDTVVNPPGSNAGQPTDDEVFSPYDYWSYGPCDILHSD	4594.223939	2.313571267	0.430206019	5.37782171	7.54E-08	1.00E-06
													ACATCGTACATA	1.592888162	0.018593655	EMC	xgb	Is known to be	GTPSPTTAQTCSDHIATPEWPGLYDVPTLDEPDEALPDLYSGMPLGSCLYSDAGPMLEAMMGGEGCWAPLMTTQDALDWAIWAGQ	511.1722915	2.292092682	1.210213061	1.893957979	0.058230588	0.217968877
CTCTATATGCCT	1.521113047	0.018593655	EMC	cnn	Is known to be	FEDFGPAMSWLWEFDFDEFHLVPEDPDTFLGPLGDNMFTPGAVDQNLFECPELNFNEQAVNLEFPWGAMPKDDEAEQGPPIDLHI	3736.025783	3.656939227	0.382670283	9.55637108	1.22E-21	5.93E-20
													TGGGAGGGTCTC	1.059892856	0.018593655	EMC	Both of them	Random arrangement	DQDPLDSFPHTMENSDAEQCDETINYAADQPDHNNPHGCEFDMALNTVDCFGILYDTWDPLDFAYILGLGSDPPSSPVEPDGQYQ	4369.677474	2.464301965	0.438895846	5.614776235	1.97E-08	2.84E-07
GTATATTACGCA	1.514128901	0.018704263	MH	xgb	Random arrangement	LCNMTTFNPVLHRVTQECTEFPTEGSWDTASDAPHTVPASELENDPDICFETGWLDDMNSACFWPEVLTNTWDDVQNHLPNEWDT	1114.229819	2.077388228	0.51147197	4.061587636	4.87E-05	0.000465426
													CCTTGATCCCCT	1.088586817	0.019204379	EMC	Both of them	Is known to be	IPDHMQMLVEQITDSQSCEWSWGSPPPDDPSICHESITPILGEFGWQTPPPEESTSTDPLFNNLVDNMFACWPESELDLMAREAD	4460.218681	2.787562245	0.31182604	8.939478718	3.91E-19	1.45E-17
TCGCCGATGTCT	2.256041935	0.019492645	MH	xgb	Random arrangement	WFSWEWYPSYKSMFCAPPDEGMYLMFVAEDDWAMIWNALHSEAEAPPAEFSAMVFHGTCEGCQWDGCMDWEWYHYITFCGEPDWF	308.5796053	-0.37528899	1.270640806	-0.295354114	0.767723382	0.910417912
													AAGAGTTATTCC	1.234874603	0.019495522	EMC	xgb	Is known to be	FDWFEQKPCLQEQTPYTPYPLQGPEACVDDVLDLVCSDMLEQMSNTDMDSSLPALLDMLRDDTWNLNQILVPNELENNPETGWGQ	1699.55695	2.874384199	0.592620356	4.850296098	1.23E-06	1.43E-05
AACGTGGTCAAA	1.56311041	0.01963273	EMC	Both of them	Is known to be	YDNTNPPSGFENPFVVELCDWRDTIDTDALIGPVPHGAPDLSMLAFQEFIDMLTMQLAEGSGSQDMQEWGSDWLEQPATGPWIIP	261.3047295	0.559036747	0.876993677	0.637446725	0.523833901	0.780820201
													AAAGCAAGATGT	1.05678338	0.019701327	EMC	Both of them	Is known to be	TPDTWCPQAPEGNIDEGPSTHPSDDFPPLPEEPTTYWSDALRDLSLDPLTPELCTTSFQAADDMIDFEQWFMNTYCANMYAMNSS	3856.706694	2.76374481	0.353797043	7.811667343	5.64E-15	1.45E-13
AACATCTACGAT	1.16075404	0.020000803	EMC	xgb	Random arrangement	SPDDNQPHPPSRDVDAQDIVPYVYDPFMDVQFLDQLGHDWRDAASDAVYDFNPVDDQYFTQMTQTTCWLPTMEMIQHPWEGTDTP	2072.120597	1.779952662	0.450393657	3.951993181	7.75E-05	0.000717953
													TTGAGGGCATGT	0.958858093	0.020529901	EMC	cnn	Is known to be	CHQDQCNADMPGSGDLWMSGHCYSRARTPAWEMSAIEGLSMWPPDDAQSVYSQVEFESLLFPIPEDMRECLDMDLFDLSLDELPW	5095.254024	2.191667995	0.482000376	4.547025489	5.44E-06	5.77E-05
ATAATTAAATGA	1.249387678	0.020534923	EMC	cnn	Is known to be	DGPPKDTFGQDWALRPPLCDENECFADDILGSPSALFDMFDLSFSDLILPGYESFFGLGNTPADDAPFNMDDNEVWNEGPGGGAW	1302.602306	2.809842224	0.383575549	7.325394524	2.38E-13	5.39E-12
													GCGAGATCTGCG	1.008379131	0.021779882	EMC	Both of them	Random arrangement	EAGIIIPDSQPLIPETPVKILPCAQDAHDLSCDCINCSPEGGAQDSTIPQLDMWGGSGILSELDMLDLPGWPEYIDPAELDVFWA	4347.788744	2.954247263	0.392674885	7.523392451	5.34E-14	1.28E-12
TGCTTTTCTTTT	1.100986273	0.022754242	EMC	xgb	Is known to be	ATMLTFPAAFPQEPFPLLDEMSDNEFGEVPSMADWAPGSTAETDSWFSSPQPAPEYAAQAVAPPQLDDVSDMFVTEYNPCLWWLS	2682.03257	2.465837164	0.462810835	5.327959023	9.93E-08	1.30E-06
													CCAACAGAGGTA	1.125909189	0.022880236	EMC	Both of them	Random arrangement	HWPPMLGPEVEEPPFLEMPPEEWYSDEIHTCSYDEFHSGAWVEIDMLEAEDGWNDSWLDGQFNDNNDTPLEELVGSLLHDFIPMD	2232.518059	1.995885189	0.399050683	5.001583188	5.69E-07	6.89E-06
CGGAAGTTCGCG	1.135318653	0.022962335	EMC	Both of them	Is known to be	SMLDPSACAQLFDISMWDPLCEAEADWAEWWGIAQPGAVMYGNTQLDPLDWLMPSAMQESEDSMECPQFWESGEGTSQWPGWEAL	2709.969879	2.694220053	0.394707663	6.825862037	8.74E-12	1.75E-10
													GACCATCAGTCT	1.599335124	0.022962335	EMC	xgb	Is known to be	FCDQNHENSHLANDLLELLEPGWGDPYPTPSEAPEEMSLHDIFDVMVDGFESLMPPPLGEPTTQCELQGMTICTWEEGLGYATPS	1441.159795	2.722638532	0.499483021	5.450913084	5.01E-08	6.88E-07
AGCCTCGTTGAG	-1.045857279	0.023372582	EMC	xgb	Random arrangement	PEWSTNDLYFMDDPNQWWDLDWQRPEPHEDDDHMMEDHPFHEMLGSFINPPPAPDSCCDHFFPISDSYIFAHDNWETCTLPDMFP	2214.791448	1.204754332	0.451092578	2.670747403	0.007568258	0.044920101
													TCATATACTGTA	1.097995541	0.023556481	MH	cnn	Random arrangement	WDDSIEMWPPYDLMEDMIMQNIEAVHASQGWCWDDSAHSQAFTHPFCGAPTDLMVRDTQNNEAPASEWFEDIFSDMCSNLLTTNF	1842.348034	1.549201199	0.326165614	4.749737958	2.04E-06	2.30E-05
TGATCCAAGTAT	1.614411445	0.023932675	EMC	Both of them	Is known to be	DWQLMDQMSHPDDWLCPELIGGGFSDEGALLDQLYEALVEFDCTEEPDLDLSLPELEDQWKFPAPPCPPDGDSNWYTGGPTEEPA	1385.451928	3.057010888	0.356594453	8.572794282	1.01E-17	3.34E-16
													GTCACAGGATGG	0.981063302	0.024371418	EMC	Both of them	Is known to be	FTDVHTTSYPIVPWIPCLQDLRTYDVPWIPSPIEFSPEPLWLPNMLDDLAWNEANLDFKDLYDVFYEVDGSFHAQQFPSSGNGST	5797.133801	2.755914508	0.27533456	10.00933012	1.39E-23	8.38E-22
TCGACCTGTGAG	1.407610753	0.025506233	EMC	xgb	Is known to be	MNESCNQCYPNDDMLYFYEAPGYDIWAHWWPPGSSNATGIFDWLDLEPSSSSGSVPASIPPQTPQPSTASEALSDFELTFLGLEG	1074.733753	2.272360324	0.440297141	5.160969974	2.46E-07	3.08E-06
													GGCGCTTTATCT	1.400560938	0.026607366	EMC	Both of them	Is known to be	RDVEALEGLLDGIEDMLDYAMSWEPCQDCTPPDWNPGPLLEPLLAPSSNLPNLHDGGGLELDHGFSGWLDDGGLPESGDEQWLIG	2267.456471	2.920803821	0.625522766	4.669380521	3.02E-06	3.31E-05
TCAATTATTATA	1.237898968	0.026659198	EMC	xgb	Is known to be	PYGMIAQTVTDISLPELPDWAQDPFANTIPLDDDMCHPSMYTELWGSTEFWDESGAGMWHGLIPNPQELQDWMDDFPLASEASVI	641.0475175	1.511216726	0.789190822	1.914893945	0.05550603	0.211932115
													TACGGGCTCCTC	1.149021449	0.02679397	EMC	xgb	Random arrangement	PDIDNALWQLVWDFNDLEPWPDPMYDFLEDQLGSVGYPVESTGTNHPQQSPVENSYTDLDAVCWTLGPVMYSDEFANLPVHGPAW	1408.772568	0.596089764	0.561698054	1.06122811	0.288586248	0.59444449
GTGCAGGGCAGC	0.955762756	0.027110878	EMC	xgb	Is known to be	MDEENSCDPTISENMPNKDAHMAGPDGSFWSLLFTELDAFDEFIPESWTTPELNEILDTFLNSECLSEEFNALPYGLGLCSHRGL	1492.999185	-0.263691802	0.591626793	-0.445706321	0.655809398	0.849802177
													CAGCCGAAGCTT	1.77082623	0.027707016	EMC	cnn	Is known to be	IFDDGMWGSSMQFLNLPPQHVSPNSQGHCEPPRESTSPANSEYPPQDELWSAFDMPDLWGPEVWASDCPLSPEDDALIMHALWDL	809.5576008	3.856108293	0.620458088	6.214937585	5.13E-10	8.63E-09
TACCGTGCATTA	1.502856356	0.027847637	EMC	xgb	Random arrangement	DLCPFFRTADATELGEIQCGCWNREEPSETYVQADAMFQNLPPSFPPAFDQPDWHNMPATPFELDNDDWEPPMCIFADTIDYMMP	403.5247589	0.984965748	0.766455255	1.285092302	0.198760031	0.488052659
													CGTACATTTATT	1.273836191	0.029215088	EMC	cnn	Is known to be	FECMTPLNISCSDDEFDWFNMYNTEANCVPVMEPTDQWRLCELIDLDGCMAEDFDAFAGMNEVVGMIPSPAEPIPEPHPINDEYP	1247.385731	2.342135392	0.535869043	4.370723447	1.24E-05	0.000126282
GGCGGAGTCTAA	1.661830274	0.03039262	EMC	Both of them	Is known to be	GGGVARPMPPTPENAPNMEAVCMAQGCSPTLDLTLEAWEVSQENLGSGPEQSAAALFGELSAPEHCLQGWDDSMFLDWLGNIIEE	2807.031028	3.755407141	0.545360396	6.886101682	5.73E-12	1.16E-10
													GTAATTGATTAA	1.325647744	0.033007892	EMC	cnn	Is known to be	ASDDVFMDPLFANLLNFDQNTTSDVLAPHECQAHAPFNPVMPVYEPHSGLRDTNNMHDLLEDLLKDCEGNLIAWLPEDIGYSPMG	1787.738652	2.73489735	0.530172406	5.158505646	2.49E-07	3.12E-06
CAAGGTCTTGTG	0.820705836	0.033234016	EMC	Both of them	Is known to be	AIAAADPTDTNEYVAEWTENLSSPHFYIPDVDQFNSFEDFFAADPEAQAMEPSDPFPLLPCDFLALFESEVQQGVIYSIFQDPLD	13539.16734	2.139092304	0.256388064	8.343182093	7.23E-17	2.21E-15
													CGCTTTTGACTT	1.635760883	0.03325475	EMC	xgb	Is known to be	LVEMSCECPQMHTSMEDVPLPSEPMFDEPITWEEPAGSSDLNTWPSSAADLMGELMGLLEDDALSLTCMELDELAAHGATRTGGP	559.2276037	3.210821998	1.160056556	2.767815052	0.005643347	0.034486348
CATCCCGCGACG	0.999728313	0.033257774	EMC	Both of them	Is known to be	TDGPMIDLEGLGAIPLNDPKPITIEAYYAATHETNSAAGLALGSPLMHAPSDVVSSMMENLFDDISWNDEFWFATIMPDPEDPWQ	4157.703523	2.349848348	0.333285376	7.050559425	1.78E-12	3.76E-11
													CTATTTTCCCCG	0.941594944	0.033551133	EMC	Both of them	Is known to be	GCEDPLMALIQDDLLCPAQPASEPFDEYELLRELQMFSSQDLEDVFSQFDNDLYVMYDVGPNFDGDLDPPPSWLVGQLSAEVEGP	4726.505973	2.314271768	0.343661311	6.734164402	1.65E-11	3.23E-10
TTCAAAGGCCAG	0.951367939	0.033968364	EMC	Both of them	Is known to be	PSMWEPGPPGDVFSTIDESPNIDPDAWAEWTDNILDFLDPLSPQWLYALFDNSGDPYPARDHPTVDVNNEFISPNSPGEMSSQAG	4177.135811	2.347757107	0.334800851	7.012398864	2.34E-12	4.90E-11
													CCGGTCATATCG	1.601923214	0.033996957	EMC	xgb	Is known to be	PPMETNTVHEWAPDLPDDPHVSSPYQALEQTEQTHSSWSGSTPRLSPDELMNLDITPLDGSSPTAWLEGNAGPPEYFCLDWHDGL	926.7316799	1.795602458	1.138355972	1.577364641	0.114711647	0.344970219
CGTTCCAGATTC	1.015521135	0.033996957	EMC	xgb	Is known to be	GCHCSAPTNMHDLLQGTLFGVDESDVSDQVFNISPMPAIWSESPPLPVDEMLFDLPLLAAEFTLDEWDVFNPSMDALANAQSPEQ	6552.272037	3.051544667	0.330734639	9.226565075	2.79E-20	1.18E-18
													GAACGAACTGTG	1.425181324	0.035049083	EMC	xgb	Random arrangement	LANNEHSNWDDDPNLCNLNYAYTEEDNIWPNLTTEHACVDCWLQGWEEIDNMDLAWGIANAWSLMDWKQDTNPVEEGPSTFELPN	514.9300725	0.914022988	1.206146123	0.757804523	0.448568014	0.729383472
GGTCTGAAGATA	1.421839047	0.035135205	EMC	Both of them	Is known to be	GWDLFDDIIQESNNEQLLYAGLLWQPALPSDLDGMPIPGSASLFDLEIDEFNKGQDLPCFDDAARLGDGSQASEASEDWFFDTLE	841.7170555	3.194802401	0.699971325	4.564190398	5.01E-06	5.34E-05
													ATATAAAGTGCT	0.918552722	0.038975766	EMC	xgb	Is known to be	DAATDFTSNPNELIELDDDTLDNEQSYDMDDFWLDAERLLALEDFWWGNLPSLGDTELSMPVHTETMQQLNAMVCSGAWDIPQDM	4067.584844	2.24834894	0.398805586	5.637706733	1.72E-08	2.50E-07
TCCAAGTGGGGA	0.989124001	0.039109349	EMC	xgb	Is known to be	SGGGSVFGSIPTNDLLNMTDPDMLGSGETDLWQPDVLGHDDLSWFDIDYKFGSLLDSLIAVDASEGCKLALDDDMPLVGSEPGDP	4447.665827	3.593838668	0.381518268	9.419833782	4.52E-21	2.04E-19
													CTCGGCGAAGGC	1.235213341	0.039495304	EMC	Both of them	Is known to be	PNGTDLDSFMGGLGAQLQHPMGANPPEFPADLDLDYAEADMEMDTMSLILNDFQDSSLCSFAFDDELGGEGGGLDQPWSNGGPWS	2816.659385	2.071811426	0.486070669	4.262366687	2.02E-05	0.000201298
TTCTGCGCCGAC	1.302432054	0.039656979	EMC	xgb	Is known to be	DGCTETGSQPMEHNMDQLDMVHNLFGDDLSQLLEDLSNPDHGGGHCGNGCWDKWMSDMLNLFDDIEWNDDFIRHGQPVVPGGSGE	2025.235526	3.048397037	0.588745928	5.177780245	2.25E-07	2.84E-06
													TTCCTTGAAAGT	1.400807483	0.039795333	EMC	xgb	Is known to be	YLGVPNPSTYADMQELGNPATMFVPVLSFDDLLFPELEAFDTFIPDSNNSPLGNWLSEAQSDECSNTGQTLDRWLWGYDWPWAWQ	839.3191173	2.252574248	0.49744246	4.528311174	5.95E-06	6.30E-05
TTCTTGTTTGGA	1.11251109	0.04006833	EMC	xgb	Is known to be	QEPSWLAVSSPFLPGLDDDPLSMQHPMIPDFTYDDFHEIDFNDIFDGLRSHLADEAFGRNSGGPAPGVGSGPQEPYGLGPVGGME	1312.005464	2.331425043	1.097865397	2.123598257	0.033703751	0.149405896
													TTTTTATGTGTG	1.065216684	0.04010311	EMC	Both of them	Is known to be	GGQDGVENGKAPRPQVVQPEPFVAIADYFASDMTQLSPHRDLFMGDFLLDNLDAPDWSFDAMWGWQVPQPAPFQPYQHPDDDGNA	3277.534429	3.168252356	0.431570396	7.341217993	2.12E-13	4.83E-12
ACTGACGAGGGC	1.64329437	0.041140518	EMC	Both of them	Is known to be	NRDSFGPPVTGVFDQLLGNDYLYELQAPAPWDASSAGPTSPYPRSSTNLFEDVSLGDLWNDDASDPPFNLDDLWHVIDHNMPLEP	1723.012354	3.684075384	1.421416507	2.591833826	0.009546587	0.054445208
													ACTGTTAAGGGA	1.16546944	0.041428386	EMC	cnn	Is known to be	AGGGSPFAMSEGWADPPHELELQQWTFNIFGSTIEGMLDLPDFDDAPAEIGASILGLDNAGGTGAGGFDPGAGQEGEVDMYHDKR	638.5501762	1.359046496	1.18761498	1.144349406	0.252478762	0.555386037
TTCAATCCAGCC	0.907892794	0.042665943	EMC	cnn	Is known to be	TCAELNMEHLPAIWEDAWPPPTDSEFAPYDSQLNPFTPRLPDMCMPSNDTPPATLRPSWDMPGVESADLCALFQALGAFEPDFGL	3028.433187	2.071745478	0.446388446	4.64112702	3.47E-06	3.77E-05
													CAGGGTGTACGA	1.11388747	0.042832033	EMC	xgb	Random arrangement	WENTPNHTGEFDEGPDNAFYDPTWNGFQEEFVWPTTDHTPDNMDVVHPMFMIDMDEADSSDVWAHFCECSGDTLHDIWQLPFDAL	3224.146209	2.900242918	0.451883148	6.418125865	1.38E-10	2.46E-09
TACCACGAGCGT	1.327328868	0.043335962	EMC	xgb	Random arrangement	MPLQLNEGEYTWHADMEDHHMDDLPHTFADHPSGYDTYYINPPPFNQLPQMEGPILNANMFRPFLHEWEAANDDPWVDWCWSSDF	352.6491311	0.490203073	1.268014772	0.38659098	0.699059037	0.874220688
													CAGATGGAGTGC	0.976122114	0.043724344	EMC	xgb	Is known to be	GGGPSGGSPPPDDPTEPKWMCLNHNKLSDDMDGSFALDRLFTDMLGWDPSDALDVDEFGFELGAPPQQGGDTEDEPMMFNMFEYH	4031.348751	2.453836007	0.408519218	6.00665991	1.89E-09	2.98E-08
CTGCAACTTTGG	0.984864968	0.044564947	EMC	Both of them	Is known to be	HESPDLWCDPLPDQYELFEPGLDGLDHLLGMDQYNIDDLLTQELRDMDIPLVPGASVIDEPLGAHEGGSGSEGDEECHGEKISRP	2675.219106	2.318572176	0.469871262	4.9344839	8.04E-07	9.55E-06
													GTCTACGGCCAG	1.223741511	0.046727067	MH	xgb	Random arrangement	THSQDTMYPNPFCVPYMGLWGTDQDADMSPINDQDEGFPSEVDFWITNYVSDNNIFTFNLGQIANEWDQELNSCFETPPGEDMDD	1058.526105	1.623644138	0.786424653	2.064589573	0.038961851	0.166317771
GTCCTCAATACG	0.826300721	0.048516747	EMC	xgb	Is known to be	EPAKPSGNGMWDHLEDQLFEFDTVFDFPEPWEISEELFAYPSLQTQNALPELTYMDWNFVESFAEPMQELCRWGLNQDENPHDVG	6464.708	2.792655406	0.359515197	7.767836883	7.98E-15	2.04E-13
													CAATTCCTTTGC	0.831227396	0.048686142	EMC	Both of them	Random arrangement	PIPAQPEDTYTALIDDDFMPEIFPGIFMDVEINSDEAPWDGCDQLCMDLEDWCHVLDNQIPMPWPGWDVEEFCNFMNLEWFGDPV	5618.669025	1.450448693	0.266773018	5.437014222	5.42E-08	7.36E-07
CTGGCGATCCGG	1.509261177	0.049857543	EMC	Both of them	Is known to be	IALGDFPQVLQPIQVDLSPPNNMDTPEWMYETVFAASVHPSNSGTMDHSLCPDYIEDLLNWFDDIENPTGASDPVMPSPMWWWYE	506.1159552	2.448081075	0.467755573	5.233675912	1.66E-07	2.13E-06
													TTAAAGATTCGA	1.057173885	0.050012032	EMC	cnn	Is known to be	GCMFPDTPWPQNNGIMLEPEPLSEDCGAWWVTTPAPLDAVMCDEPSELPWSPGSLELLVPHLSPAYFMHDEQGWEDCTEINMWLD	2196.392731	2.081658767	0.392747232	5.300250632	1.16E-07	1.51E-06
TTGACATCGACA	1.59960326	0.050486623	EMC	Both of them	Is known to be	ALDVLPHDPWGQWFAEDFTAISEELALNELLDNHNFDALWDLLGDNLSDTPSLGDGQPGGGSSCSWQFGFGYEAGLPAGGYEGPH	1045.805825	2.306082466	0.58880701	3.916533649	8.98E-05	0.000822928
													CCACGTTTAAGT	1.062422042	0.052772993	EMC	cnn	Is known to be	CDNAMTDDDYICFDYLMDPVDYNLFGWYDGPDYANIPDLIEQELRDVDILALLDPRLDPGVHEFGEMSGAEGSPQGGGGGEHYAM	2431.151176	2.648346079	0.607260542	4.361136445	1.29E-05	0.000131404
GTTTCGCAGCTC	1.459966262	0.054275878	EMC	Both of them	Random arrangement	WFSVPEQEAWDTLANLYWGDDGINDHFPVPVDIQPDVLEFEWAMPCFDPIIGPENEHGPCIPDGELPLELAWTLDPGNDDAMHPP	890.7711605	2.575647313	0.767302721	3.356755088	0.000788629	0.005957999
													ACCGCGAGGCCC	1.081160711	0.054628753	EMC	xgb	Is known to be	FPVPEMIDLGTIWPDLTTIPEREEEGEPFVREWFPLDCPEFDLNLDFSCEQHLHEILDTILPDEEPYLPMHMSTGASIFETDFWG	3702.869437	3.415053974	0.441511907	7.734907981	1.03E-14	2.59E-13
CCTAAATCGTCG	0.895234697	0.055394289	EMC	Both of them	Random arrangement	DIDWEHLPGDDDSSMAFDSEWVEHWCSRSRPTCINIPMPAYAGQCSHDDKPLEPGVEAMQFPNDFLESQLPEALMDFEETFMFPW	4137.848285	2.022660692	0.427938578	4.726521039	2.28E-06	2.55E-05
													ACTCAAAAGAAA	1.45110571	0.055488103	EMC	Both of them	Random arrangement	ITPPDVDMIDIDPMEDPFMGCYWPETDECSAIHVSAPQPYTPEADLGNFWRNDFSNTDPYHGNSLEEDLCQDLLDMVALDPDGWW	570.8229429	2.435772694	0.601549251	4.049165869	5.14E-05	0.000486297
AACGTGGCCTCG	1.063125422	0.059568712	EMC	Both of them	Is known to be	RGAVAPQIEIPCSAPQDEQAPGPVLEYRPMSCTLEHFSLPDLADLQDEDFDGLSNEMQVIGNWLSILENGGMPEFEHFWDLMDKE	4663.068086	3.029107746	0.407391258	7.435377377	1.04E-13	2.46E-12
													GTGTCAGCGTTA	0.860504926	0.059568712	EMC	Both of them	Is known to be	VEECMWEDVIDKIMPPMDHVWGIGPDALCTDYNPGPGPVLQGWLGEVSPLPSVSLWDHGDDFHLSSMDPSSKLDDFDYTNLCDMG	3531.710966	1.916214268	0.427152258	4.486021633	7.26E-06	7.62E-05
GCCTGTGAGGCC	2.487869892	0.063693781	EMC	xgb	Is known to be	LLDIPTDFDFAENLPVLDDDGQSFEDAVSAWYDLPFPPPRSWWDLLEQEPYDYSCFDELCLDASPMVTPELALADPDLGWMGDDD	200.4394615	4.046262688	1.287057103	3.143809764	0.001667638	0.011673467
													TGCTACAGACAA	1.586007168	0.064155108	EMC	Both of them	Is known to be	NEAQPTLEDQAWIQFQGLLMDEWLFDNPDPLEHIQCMSTCDLADGCAPPFTPLNMPELWNPLTPEWFMGYDPCEGALTDPQWFDF	1193.609723	2.781958286	0.800088348	3.477063869	0.000506937	0.003975285
AATACGCTTCAA	1.198788473	0.071261037	EMC	Both of them	Is known to be	ARIHHVMQPTPHEMSCLEQLPWMGPGSMDDVDWSSLGPGADMPDIFDELMSSDVFRVLDLSPLPASGVGTVLEADIDVCQTYDSQ	1117.216265	2.27352054	0.386734617	5.878761398	4.13E-09	6.28E-08
													ACGTCCTCGGCG	0.999863547	0.071707829	EMC	Both of them	Is known to be	PDPQIGPWDALDDMDLLEAPNIDFDAHLLDWLQDAYLDDLSNPSVESNVLDDGLLTTTLGFMGQYIPSHSGSHRGMGGAPYFKPM	4920.800709	2.364701694	0.278886903	8.479070449	2.27E-17	7.26E-16
TGATCGGTCTAC	1.01135485	0.072269609	EMC	cnn	Is known to be	CSDSPHSANDFQGWFDNNDYADDTPFACPWPDFASFAMGMPAMPESLSPRNDVPAGDELLLSALPDMTGSEAFDEFMYELLTIIE	3240.033364	2.742149155	0.33791799	8.114836243	4.86E-16	1.41E-14
													TCGTCCTGATGA	0.99170622	0.072844177	EMC	xgb	Is known to be	PSGGPSGEEDVVSRNLEDILGAVTSDEQAIQQIFEDSLMCDTSFDDLALPLSQLGIHLGGGTICPFAQDTENLDDNEWTCMLFDK	3363.877851	2.644819965	0.321612394	8.223625748	1.97E-16	5.86E-15
TCATTAAGAGAA	1.510648425	0.073054865	EMC	Both of them	Is known to be	FPGTFGNWDQAMTKDLPPVLWGPSLSDEWPMWDQLDMPMWADLSDAMNSTEDVLSTDFLNTLWGILDNDNTHCGVGGVCGTQPSD	706.0666055	2.60496855	0.501874889	5.190473971	2.10E-07	2.67E-06
													GTTTTACATGAG	1.39728983	0.074994939	MH	cnn	Random arrangement	ELAQLMPYMTTSQAGVQPEDHLFVDPHVHNVCYEPELPSQNTPVDHENSPLDLLSGGFIEELWDEILAFPVDWIFSDWEEVGTEA	678.9787266	2.533953486	0.605899527	4.182134783	2.89E-05	0.000282849
GCGTATTAAGTA	1.063329795	0.077061106	EMC	Both of them	Random arrangement	PWLEELQYWDWYLDQNEGDTEALPEVLHDEPQPRHEPPNPPAMEDWNPLSEYISWDFGYCDAGDMWGIMSDLINQDDGAFSPQST	2952.376268	3.275913405	0.604208431	5.421826702	5.90E-08	7.97E-07
													ACGCCTTGCACT	1.238974983	0.078455385	EMC	xgb	Random arrangement	SSDPEPSNIECGASYMDYFEFPAFWDQSVFEVPLDCRPAEFSMERRPHDDSLAFGEVIHDAIQALMMGPQPYWDPHDDDPPPCCF	1161.311284	2.343123557	0.560160566	4.182949856	2.88E-05	0.000282395
GACAATCCTTTT	1.087568544	0.078965637	EMC	xgb	Random arrangement	VDNPPTDSTVNMPLHPEHSHQAQCFHEPNSCNMILDYINAVGITEPMEQWLHNDFFCPDAASLCEQGDCIPNWFEYVDDPLGWPV	2136.974915	1.330170116	0.376497503	3.533011792	0.000410854	0.003300151
													TAAGGCAAATAA	1.354463512	0.080273044	EMC	Both of them	Random arrangement	GTADPMQESKPKGHCQQVATQPDQPDWTMSAGSPKSFNIDESWFEHLFPIDLDPFAFLDIQNGLADLYFEDDQVELSDNPVGYPH	1281.63918	3.105100014	1.067662827	2.908315187	0.003633819	0.023665186
CCATACCGCGAC	1.238833894	0.085536334	EMC	xgb	Is known to be	CDDFEIQFRTPPWVGPPMFDQLLEEVLADNTPPPSHAEPQTLDNCYDLDMTLPTWTQLAAFMNIEHAFGGLSDNLNFDDIDIGMG	1693.381549	1.509936012	0.401190571	3.763637835	0.000167459	0.001458574
													TAAGGGGTATTC	0.882160586	0.085805723	EMC	Both of them	Is known to be	FDADASPLADSLFTDIAGNGLPFFNAHDLDASWDPVPMSGWSSWELNDLALSGLWELGDILADYPKSMEGSPDAGGPADFADLMF	3492.335706	2.123958736	0.34950881	6.076981962	1.22E-09	1.98E-08
CATTATTTGATC	1.242334654	0.088998747	EMC	Both of them	Is known to be	NGGTPETQCGSWSGKQGITCEPSFYDWYDWYEFPTAMLQHELPELWGFDTPDVTPNDSIGDLRISPDPMEELEMLLGLPEPWSPT	1609.776922	2.275132397	0.338560151	6.720024172	1.82E-11	3.50E-10
													ATGACCCTACTT	1.120298384	0.089644903	EMC	Both of them	Random arrangement	GDDNHLGNNGVLNDSNNLIEELLGWDYWGIPQPESPLLYGHEIQIDCWMPCPRYSPEDIGEPMDMPEMDPPHDVPAIDLMSDLQQ	1773.18272	2.827133615	0.70112301	4.032293301	5.52E-05	0.000519441
TTGAGGATATGA	1.005348594	0.091696334	EMC	xgb	Is known to be	SDTPNNAGSIMEDSNCNIPTLEGYDTLTLDEFLAGSDFGDLWKPIWSDPYDLDLNPFVFVPAITSATDQQIESEPTAVMMDTFAT	1601.642966	2.984039958	0.443719387	6.725061027	1.76E-11	3.40E-10
													TCTGAAGAGAAA	1.22535406	0.097816237	EMC	xgb	Is known to be	RESVGPQTSLWGWPNDPHQWALHDVTDHPQNDATTALSANKPSGWTIDELMSSDLGSWMCLTALPDMDYNFVLDPNDIDLLGFDD	549.1390752	2.351847801	0.76176278	3.087375574	0.002019323	0.013880394
GTTTGACCGTCG	0.97334251	0.102062656	EMC	xgb	Random arrangement	SVPGMEPPLPPTYWASLGCNADCMVECMPHEAPTTDYDDRVLYEEFDIYNFVDDMMQFTLWPPEMQDDEDMMHAGLDASIPDPGD	1516.721171	1.894818755	0.443668898	4.270794649	1.95E-05	0.000194229
													CCCATTGACCTT	0.754869028	0.104788444	EMC	Both of them	Random arrangement	PWDDVNWFVQEEGTQIEDDQPEQPFHPADYITAPTHVRTAAPTFDTYNDLDDLNNPMLDWWNTENLHTWCEFFPLIMEPANQSPE	8858.531222	2.855228564	0.322595503	8.850800878	8.69E-19	3.10E-17
GTACCAAAACAC	1.381719665	0.111266904	EMC	Both of them	Is known to be	GNMTCDLAVDAPGGPVWETHLTAPDELPSDPMLDDFWLDLLDHVGQELPPLGVLSKDMLNLEDWAECTDWFSQSGTDGGDARNDK	1184.704884	9.345969355	1.882505198	4.964644648	6.88E-07	8.26E-06
													CCATGGGATCTA	0.916129186	0.111612694	EMC	Both of them	Is known to be	DNMTPLLEDLANIDWGAVPLQPEESHCQWVMPPQFSLMYPSIDEMRNPSPMHLDCWGLFSPLQEELEDWELLEFDLNVIPGDPPY	1270.948453	2.081030678	0.540756561	3.8483688	0.000118907	0.001062463
TACGCACGGGCT	1.215069064	0.111612694	EMC	cnn	Is known to be	EDEEMWETRSDYMSAAVFREHAIEEVVYDNLWPPEGLEPPNLHELYDLDVNAMDDLHWEEVGQILIPDDFLPLSLNCYEEFFPDP	1694.365972	3.176125038	0.620376315	5.119674885	3.06E-07	3.77E-06
													TTTGGTTACATA	1.339695443	0.113127173	EMC	Both of them	Is known to be	FDFCLEPLDIPLCWDWDAWEQDVNAEQNWMPPGESGLQQPLDPYDLDDFALALDEAARTNDWQIYMDDGTQMFLDALEIDDMSGH	729.721501	2.14502596	0.505748046	4.241293621	2.22E-05	0.00021984
CGGGGGCAAGTG	1.081667821	0.114203045	EMC	Both of them	Is known to be	DTGKVLQAPNQEQIPKLPLFEDLAAYFDQEYCPMWPGPLLSGELEGWKESGEDAATMLENGDMLDNVMFSLESWPLGPEDFHGGP	1539.741525	3.596535406	0.688770006	5.221678317	1.77E-07	2.26E-06
													GAGCTGAGGACG	1.880670894	0.114203045	EMC	xgb	Is known to be	TFFDTDNIGLSNDIPDLFYEIAYMGWPPLADETTQHNDTCELHTTHPETDILLGGVGDMLGDGSWFPFGDGSDDLFDLLGECWAQ	451.6239885	2.733873653	0.858988506	3.182666165	0.001459258	0.010346324
TCGGCGCGGAGG	0.982952819	0.116039372	EMC	cnn	Is known to be	GHAIEELDMLLSLTEIDMTQDVAADHVRHSPPYSTTGGAMNLVLGNQYSNTQAAPAEWDGMASPQQEIHPLLELMPTIYDFEPYT	1379.701448	1.371728602	0.456385472	3.005635996	0.002650261	0.017725629
													TCCTAATATGGC	0.91640232	0.117603625	EMC	xgb	Random arrangement	FPQEAEDTFASVHTCCRIQDASDAPPFMPSEWGAVHDEIPDASQVLWPNCTDWQDFMDRFLGDPTYDCFEMPFGADEQYDYWPMM	3895.466532	2.3838148	0.417232455	5.713397339	1.11E-08	1.62E-07
GGGAGGTGTGCC	1.050747733	0.117911342	EMC	xgb	Is known to be	GQGGRSQPGAGPPGPSAPESQAMEFDALPSMMPDDALDDFDLTDSDPSLAQPTWDHFTYALADPHSSQDWQMFTDALACMFFDMG	2225.309254	2.709289583	0.571290693	4.742401053	2.11E-06	2.38E-05
													GCGCGAAACTGA	0.95914936	0.11912013	EMC	Both of them	Random arrangement	DGMDGWLTEWVDTLLLDQPIDDDALCNTLPWFNSCNSWDFPVDCDCICPWNNYDVHDELFAGGMINGPLDNFDVYPISGPSNTSS	2802.450263	1.861924915	0.308376728	6.037825646	1.56E-09	2.49E-08
GAAGCATAAGAT	0.859240401	0.119318766	EMC	cnn	Is known to be	RDMPGPQYYGTMDMDDVIPITEHLSTDFLMGFLDDMDLDMGFLEALWTDTAPANPGSQLPGDLLMPLAYGGSGMALGVASDGSTE	2148.497233	2.726834013	0.341757215	7.978863054	1.48E-15	4.07E-14
													TGTGCACTCTGG	1.524932109	0.119767579	EMC	cnn	Is known to be	GWGSSYSSPPVVTGPSHPFLSGVEQMHTVFRNDYEFEIPPDLYDIDAPEEALLAAPDVLDWMFQIGISTDTTPESQDSDQDLNDY	419.4714928	1.473969395	0.512070328	2.878451095	0.003996332	0.025588919
ATCCAATCGCAC	1.137545328	0.120571206	EMC	Both of them	Is known to be	FAELADIPCLNACIPCDEDEPMVQEAEWFWNICSMPLPMAEGALPERQAMEPSQLSPLDPGDLMALLETWDPYSSDWGGPEHPAM	760.5860083	2.230861367	0.722297322	3.088563809	0.002011265	0.013863462
													ACCCGATCAATG	1.714480525	0.122353608	EMC	xgb	Is known to be	ETCDLLDIDWDALLDPSDTLTGGVGLDDAGPESFFWSSIDSTPAFEYENLEDNGGGEGGCDHFQGMHGGDDGLQGEGGPGNGPWV	439.443782	4.302052098	1.154562996	3.726130245	0.000194442	0.001675921
TGCCTTACCGGG	1.086437767	0.122906307	EMC	Both of them	Random arrangement	DPYSAFEPPADAHETSEHDIMDLLGTLHMNLWPPIDSQGTIGQSGCLADAPDGASEQAGIDELLQYDWDLYCEDCFGIYGDTEQW	2023.030842	4.013622178	0.431849319	9.294033825	1.49E-20	6.46E-19
													AGGGTTGTCCGT	0.924608517	0.126140328	MH	cnn	Random arrangement	KQSTVGPSLMPQNPQQAWPVVSCDSDDFPQSPYVNHYEDYCPLASGLQTDDSPYTADWFEDLVSKAWQENEEAYQYEFGLPIFES	1853.417923	1.740973686	0.62281384	2.795335577	0.005184587	0.031995007
AGAATGACGCCG	0.81634067	0.127273243	EMC	cnn	Is known to be	TQPPVTTPNMMAGTILTLNDELVFDCIDLDNWRNPNIELLSLESPMDVDEWLFALLDEAENMDVPVGSYGGCGMDAEGGSECGDR	1845.18406	2.571139028	0.550886889	4.667272136	3.05E-06	3.33E-05
													GCCTCCGGGAAA	1.379460279	0.129668642	EMC	cnn	Is known to be	NFAASPPSMEAALMDIENEAYEFPADEDQQVFLLPPTPFQTPPLDMTHDLLMDSPEDTGHPHDLPMLFSFVLGEDGFNVAYNEFY	947.8530223	2.196132798	0.49477287	4.438668595	9.05E-06	9.40E-05
AATACGCCATGC	0.776969229	0.13009284	EMC	cnn	Is known to be	HDDSVIDGSIMDDSNPNIPLLQGYDLGTLPEFPDINDLDDLWKQAWHECIGDPSTTNTNFDSMLDALDPDAGTNLDAQTECYYAM	4553.881125	1.596327744	0.323888289	4.928636816	8.28E-07	9.77E-06
													CAACCTGATGTC	0.690968709	0.131316944	EMC	xgb	Is known to be	WQWPPDELWSINMQPHQPFLGSGWCFNPFGGVDFADNPNDMIMHDLFNTQESLDSQDMLNLFDDILSLIPAEPEGAIDPEPINPI	5292.507496	1.761620623	0.254737571	6.915433065	4.66E-12	9.51E-11
TATTGATCATTC	1.051778683	0.132745006	EMC	xgb	Is known to be	TFDEPFMSNEFTALLNNLLTQGPSLQCEWVDWLGASEDTTLEFWEPWTEDIEQGLVGLGFGGGGGGGPSGDHGDTCYVKDPTLQR	610.5050665	1.392790475	0.513682205	2.711385485	0.006700268	0.040201608
													GGTTCATAAAGG	1.973158256	0.134443376	EMC	Both of them	Random arrangement	VFDAWLDVVDEENEIFADIMPSCPDIPEPQWREIHHTFTMPMQEEDLEVGQFTFPNVEEANMHSGAPLSTGYIWPQGQDEWNFLD	446.827619	2.645554067	0.773582663	3.419872489	0.000626505	0.004866706
CCCGCTCCCTTC	0.884508089	0.137123412	EMC	xgb	Is known to be	NAYFTNSTYTDDARALPEQHTNLDDYILQQTWAISDLELGSLSAEIIDELMCSDVFPEMYLWPTPAMDPNGPLERTEWTPEKPPV	1509.242267	1.499147989	0.468586479	3.199298433	0.001377625	0.009852105
													TCTCCCGACAGC	1.370895717	0.137123412	EMC	cnn	Is known to be	YHRTGRDLGMDGNSSEPLWPSDIEEVLASQLPPPNPGDLLQGHELYMPDHAAPELPNETMIHQMFWDYVALPEYEFDDPTQWPLP	720.828702	1.64531359	0.488533237	3.367864182	0.000757529	0.005749332
CATGGTGAGAGT	0.750039511	0.138495474	EMC	Both of them	Is known to be	QPAHTDDGEICLPFLAGGLLGPFVDGDNDMTPYEIMDMMDLPDLLSTDHDQLDFDALTDNDDVTMSAFLAWLESVVTFNDNAYNF	6493.443173	2.069861111	0.46753342	4.427193914	9.55E-06	9.84E-05
													CCGTGCCTCGCG	0.841813767	0.139967567	EMC	cnn	Random arrangement	AMNPPSEFMWDMFSDLCALDSTSDQHLMHGQTEFSTPSTVLMSGYKEQIMGVGPTDFDQVDDPSWDSLARWFIEYTDNDPSEHWE	1783.2821	2.060278246	0.391226449	5.266203885	1.39E-07	1.80E-06
CTTCGTCTATTA	1.092757219	0.140466832	EMC	Both of them	Random arrangement	HRDNRDTDPNSIKHPHWDGAPDECFNELEIESLSYHSAGTTILCPGLSQRDQGILPGDLFEFDDPIEFDFNFWNDLATELYMCPE	654.1056356	1.75043238	0.574931544	3.044592699	0.002329956	0.015818168
													CGAGTGGTTATG	0.788674218	0.141114962	EMC	xgb	Is known to be	LDYPSSPSDYVGSIDLDDFDIDGPGATVAPGGPLRQDEPPFDSDKSDWLQMLFDLGDWTEDATSSWNQTEFPVCAEYDQPQSVWF	2851.125071	1.896178979	0.400723652	4.731886854	2.22E-06	2.49E-05
GCGATCATTGCT	0.777328062	0.141114962	EMC	xgb	Random arrangement	DTPFWPDFPQDLSNTNAVARTPVDVQVVDMCDPDYIALNFPYTNVPCDEEWLSEFDNQDLPDYEWFAQWYMSEVPLDYQDAMSTE	4794.111117	2.442797869	0.281561209	8.675903467	4.10E-18	1.38E-16
													ACCACCACATAT	0.865334629	0.143952846	MH	Both of them	Random arrangement	DLGDYPSDGSDGCTMTFFEPLEGLWDGICGCDNWSDVETPEDHIFDFEYLQRMDEFSYQEFDVSQFLGIGVPFGPQYDTQDIIEE	2174.457799	1.385691435	0.393247099	3.523716864	0.000425539	0.003396087
GGGGCCGGTGAA	0.942643042	0.145063809	EMC	cnn	Is known to be	FDDHINDWDELVGQPLMDPLMEFAWLDYECVYEQAPLTLPQSQIPSDPPNMWHEGTCMDSLLPEPYMTEPIMFADVGGDAHESPN	911.582063	2.604193938	0.661843186	3.934759766	8.33E-05	0.000765743
													TAAACAACTTGT	0.822855448	0.147496774	EMC	xgb	Is known to be	RPAFEGMWTWMSNDWSPGMSKELAMVEDSFQYFPVNDDFDMTLLGDTELLDDEDLATAYAWPNMDPDAYLNQWTDETWFDFDAHQ	3150.937235	2.012230767	0.473667302	4.248194375	2.16E-05	0.000214032
GCGCGCCAGCCC	0.905511852	0.147988204	EMC	cnn	Is known to be	GDGGEAYMPPIPKCNVSYLGDECCLGDECQGPLWCGLDDFSGFLGENSDSWAFADASWIDAMLEEQFGSSLDMIEEDLLACMITP	3557.271502	3.732694471	0.332945224	11.21113684	3.60E-29	3.24E-27
													ACCTCACCCCAT	1.649034885	0.149677315	EMC	xgb	Is known to be	ELSACECPSQQNPDEGPPSKVPHLLDQTQDTDISNAGSLSNDITDALMYLDVEPVPFSDIGLDVEMDDWPLEPPCELLDVLAELG	603.6420232	2.955048036	0.789298829	3.743890056	0.000181193	0.001575425
CTCGCTGTGCGC	0.877769998	0.149677315	EMC	Both of them	Random arrangement	APPCHPGPSSEEHDPLIIFDMYPGDLPMYTPHWQSLYDDLFWEEHCGDLHNMAEVMNNHVNDQFHTDELGQALDDGLLLNEFLPP	4820.78272	1.708532464	0.256901782	6.650527873	2.92E-11	5.50E-10
													TATCGTCTTACG	0.827346521	0.149752932	MH	cnn	Random arrangement	TMFDANTTNTMSTCIDPNPVALDCAGTCCCPGERPANAHPVVFDNKLCFEQFELGHLNELCEVDPTCACEVSPEALGWDWWDVLG	3921.041679	2.525138622	0.360561879	7.003343306	2.50E-12	5.20E-11
GTACTTGGCAGG	0.774319956	0.156685928	EMC	cnn	Is known to be	GDGTSEQPGARIPGDPQAMSQHLLHYLTDINSLAEDVNGLNDEFWTDLFTNDIEIGSWEIKEFIEGMNFEQYGQGGCGPQEGSLG	5182.697259	3.306274335	0.609589677	5.423770221	5.84E-08	7.90E-07
													TTTCTGGTTTTC	0.81132468	0.158312006	EMC	xgb	Is known to be	TCEGPSSNDKFAPWLQDLHFWPPPQVLDFPNEDEGISPILAQPQNHMNTDTESPPWHHLNYSLYPELEEWDHNDFLSGPPSPPPE	3130.614206	1.52351491	0.435799518	3.49590774	0.000472452	0.003722531
ACCATCAGGGGA	0.789124891	0.159109547	EMC	xgb	Is known to be	ATVAYPQSASSDSSWLPEDVDWMHVLDDAFDPSWATLLAMSMSGDIIDEEPDAHDVPLAPISPGNADGLQKCWDFFDCWWDEYMQ	3922.346339	2.05213335	0.377427458	5.437159664	5.41E-08	7.36E-07
													CCAATAACCAGC	0.883991653	0.159672983	EMC	cnn	Is known to be	LNDNTMGGVAPMDYNFGDLPDSHKDDFLLDSDVYSDLSDFDLGMLDSELAQDSVDAAMHISELMEDLGMFGEWFMPVFDSSCWRQ	2384.834045	2.327009575	0.368899535	6.30797643	2.83E-10	4.88E-09
GAAACTGCTCAG	0.888296552	0.164356207	EMC	Both of them	Is known to be	DAYVDSMVTILNDLECPLFDFPEPETPDILGLPTVFFDTAISGWSNHSLGDPHFPDLMEESGAPPDGMTCDGGGGGGNGGGQGGI	1265.416188	3.282965396	0.600269781	5.469149873	4.52E-08	6.23E-07
													TGATCGCTCAAG	1.047420386	0.167242841	EMC	xgb	Is known to be	VPDGPDLDAITDIYDDSLLGMSVVDDDDLWGLGSDALDGFDKDMFQSDWWLEEIWGDVGNPALEPSPGQSAGPAQCNGLWGHMFP	2184.452332	3.83036588	0.614101868	6.237346084	4.45E-10	7.55E-09
AGACAGAAAAGG	1.061364816	0.167624297	EMC	Both of them	Is known to be	SPGMTPADSSASIFELLCPIEPCPPPLYECHEPDLYCPSFWELFDPVNANYQGIMDALDENWDNVLPNQDMNASDRGDGTFEMVQ	1505.276674	3.598449421	1.052197999	3.419935625	0.00062636	0.004866706
													CTCTACGTTGCA	0.785360417	0.167624297	EMC	xgb	Random arrangement	MDNPYMSLLQACLESDHDETAYTDSQATYLPACPPWPFDFLIPDSPQWLGDTPDIVGDACPPGSEWCRADFDFNSEFPIMSPWFE	1803.702602	1.796158361	0.388047627	4.628705952	3.68E-06	3.99E-05
GGGCCAACAGAC	0.963312452	0.16855821	EMC	xgb	Random arrangement	LIECHPHMMGVQPSPPWLGDDIPCVLDWPPLSYTEPRANQRHYATMQSMEEAIDLDQFFENIDQPCFDLQDPGCDCEGEAGCGFT	955.0232539	1.9197796	0.493573533	3.88955135	0.00010043	0.000908266
													TTCTCGAAGCCC	1.228397665	0.174234659	EMC	cnn	Random arrangement	YDEKPEQIGVWSPRAEANDDICHDHTYMECPHAETTSLYPLSLFDSETPELGPGDDWGHFYNGVIPSPLNSMIEQPRWETWDTMS	1052.602746	1.332118272	0.503339646	2.646559398	0.008131522	0.047579486
TACGTCCTATTC	0.824773638	0.17615156	EMC	xgb	Is known to be	RFSEAFGGWQWYDMFAGMLDTSFYGLFPELLETAEPTSMQPEVQSTELSDLGDLSELLCETPSTETLANFAQHEWSHGPCDSGSD	2479.238709	2.446205101	0.407149284	6.008128211	1.88E-09	2.96E-08
													GGACCGTCCCGA	0.938027023	0.17693705	EMC	xgb	Random arrangement	NLDRWFADHLMDFWDEFDCAGFSFMMSENMNMHGYANVDWDMDNHAFEDILADWVDGPVISELCEELMGPDDPQPLLSSQDGPDD	1872.750874	2.143943732	0.483451856	4.434658188	9.22E-06	9.56E-05
ACATGATATTGT	-0.718346654	0.184302798	EMC	cnn	Is known to be	PEPGPTNASMPSQHLQMILYPEMPCVFPSDCDMSSRGSLHDLFDFEVDNWESTVNMELSPAPRWDLFGPMDNPAAEVEMSGDAAD	3167.798943	1.38857364	0.324203735	4.283027895	1.84E-05	0.000184591
													AAATCACATCCT	0.966085658	0.187914817	EMC	xgb	Is known to be	FSSQPSWHSSIMNLDDLPELPGSACDESLVNMVPPTDLSDLDNKLWWDLWIPSVVSPLLPGDVDALLEPWMPGDPLEQLAGMGLQ	1422.799477	1.996174128	0.420974801	4.741790064	2.12E-06	2.39E-05
CAGCAGATCCCG	0.726010188	0.188652742	EMC	xgb	Is known to be	GGQGSLLQSETDLPAPSLDTREPSDGIVPDAPQEDPFWADIECILGFDGDGLRDLTFPFASLLMGDDFFEQMIENTDLCQMWGGQ	4025.422455	3.101427564	0.477351712	6.497153957	8.19E-11	1.50E-09
													GGAGTGCGTAAG	0.72994988	0.190380927	EMC	Both of them	Is known to be	WHRYSQQKTVVDVYPEGSGSKWESEQEPPCDSMNFPVVEHSIAEILENALKSDGSLEALLQDMDWLMRLDCDPPTDGPLGDDLGL	2701.452007	1.363041208	0.338687591	4.024479327	5.71E-05	0.000535976
ACTAATTAACCA	0.750381799	0.19071445	EMC	cnn	Is known to be	EPDPSSWAPPCYDWEPVLHMPPIFPECMIMNPSETLDMELEDMDLGHPAQGDDFNALIDASLDKPDATFEQMFTICISGPDDPED	1582.003327	1.682985896	0.443220599	3.797174364	0.000146355	0.001283778
													TGGCCAAGGTCC	1.105403881	0.193843295	EMC	Both of them	Is known to be	LSVSDPFFVAQMDLFPEILGAIPEEWLADLLPPLAYHPDFPLDMLAEPRDPGADLQDLGSTGMWWESMDDLGGPSGPDLVCFPNK	1151.661159	1.287777828	0.33370124	3.859074148	0.000113817	0.001021882
GATTGTCAAAAG	0.731315186	0.19953724	EMC	Both of them	Is known to be	VPSDSTPSGFTDNEGDDDKPNEAWSHAPRYSYMPEWIALHSHEPLISDGAQLDFDCLRDLDLTGDAIFLDLLFDFDNEMLGPVES	3399.020691	3.136484112	0.367700422	8.529998676	1.46E-17	4.77E-16
													AATACTTATAAG	0.881799129	0.199616048	EMC	cnn	Is known to be	GHDASSDGSLLPDLFDELHQEHETIDVPYMPQLEGFTLDMLGSHDSQSEWSLPWDHAPYYGHILPPALGDEQWLTTTQSDEDFDI	1528.373989	3.245029898	0.480569421	6.752468548	1.45E-11	2.86E-10
ACTGCAGTGCAC	1.018304543	0.199616048	EMC	Both of them	Random arrangement	DPADADSMSAWDPFFHELLGDDMAIADQEPEDIIHFHPCPHDTCMEPPLHEPCCPICDIFRDLTEHCNCFAELEQFFQDYVTAFN	1102.156268	1.701588922	0.478341795	3.557265828	0.000374735	0.003074812
													GCTTCGGCTGCT	0.864103099	0.199616048	EMC	Both of them	Is known to be	GSSAMDLDDDVSEFLSAMDVAPDPVEDPQGLHLDINPLGIMTWEDAIWLCADDSSFHNIPGLDPGLCEALADDDTDFVWWDNWDA	3775.169679	3.389468583	0.470296985	7.207081257	5.72E-13	1.27E-11
TATATCTCGCAC	0.738304078	0.199634827	EMC	cnn	Is known to be	ADSSDFNPNPSMMAIEDLWCSEMSEFAPDLRAFPWATPRTEPTETYNLDWPSGVEGTYEPNDQLSFEKDILDELYCSPKIPPDTI	1958.09611	1.155048208	0.353353664	3.268816275	0.001079984	0.007941248
													CTAAGGCAATAT	0.85677454	0.205982771	EMC	Both of them	Is known to be	ASQPSGPEAGTGPEFHELYDSANVGHQASLWEALSQMDQDGLNLINIEDIDLEMFMHDPFSLHIGEAWTVPLEDGLGVGMGTLPL	2340.591618	2.447845957	0.649723336	3.767520455	0.000164877	0.00143861
CACAGGGGCGCA	0.908792714	0.210483376	EMC	Both of them	Is known to be	TEDFPHEPMEYPSCLPDTLWSDYFSGEHLSDCDFDNLCDDTPHDGLDVPASMNLLPTPVDTPLGESWEHLFAQIIGMNPWMDDIV	2207.87661	2.135603302	0.445187316	4.797089281	1.61E-06	1.85E-05
													GCAAGGGGGGCT	0.776215386	0.211748347	EMC	cnn	Is known to be	DWPDEFSKLLSQWMDDMMDNCEFPHDLPDPPDNYIRFCDPFDGLEVYESHHSILGTDHVMPDPFQIDLPGDGYGADNMGVMHAWY	1776.57976	2.218119515	0.547806408	4.049093771	5.14E-05	0.000486297
GGCCCGGGGTTT	0.817717846	0.222655721	EMC	cnn	Is known to be	DFEVDASQPQYEILQTYKDSDMDEQCYCPSLCPQGPSNPPPASTAPELDEMVRDELHLTELDNIQLWMYLLDDMFEQMSGDGSES	1225.043979	1.770111195	0.667937666	2.650114353	0.008046453	0.047193162
													AGTCGAACACCC	0.727634829	0.223162259	EMC	Both of them	Random arrangement	ERQPDIQAYMDQCNPMQPEMHDDAPQPLNPETPEPSPSCWSQYDQDEVFNFIGSLHSMYMEMFTPNPNLDDDAILSLHWGEHFDQ	4171.659716	2.647979277	0.419613628	6.310517823	2.78E-10	4.82E-09
GGTCCGATCACC	1.101864779	0.228381404	EMC	xgb	Is known to be	GRADPTQSGDAWIWEMMGMLPPLDSLKCFSDMYSTDIPCAPPIPTWHDTPSTEGVTDGLDPLPPSIESLQELEHLLGIASDGWKQ	1044.003636	2.85368111	1.0726055	2.660513217	0.007802167	0.046142646
													TTAACGCGGATA	1.870729484	0.229564004	EMC	Both of them	Random arrangement	IDYEATNLDHLDWMCDEPFGFCIHEALATANPWPPCDDEIDDNAMLDYMCEETPNHTFVPWEGSDWLGAEQEMVEPEHMPWQDEI	202.7059562	2.183549628	0.825269736	2.645861751	0.008148311	0.047621497
ACACCTATTTGG	0.980666988	0.231289336	EMC	xgb	Is known to be	TNVGFSDHTSIPIICNLPSIPGPYHGGTLDAPVCYTDFEDLMNELPSDMCFDEGGQGDGQPFWEEVWGDSFPISPETTWPSWVSG	847.066082	1.608249803	0.507938808	3.166227461	0.0015443	0.010899739
													CCCGTTTTGGTA	-0.634221562	0.231654794	EMC	cnn	Is known to be	AAPAELPCDIEPCFCITDNLLEPCVVQHQPLTPYSGLGLLDLDMESLVQPDFLLGDTADDGWDDMWQASPSWPPWEFLTNMCDLF	2522.78001	1.33651969	0.324454141	4.11928689	3.80E-05	0.000367156
CATATCCTACCG	0.771618896	0.237927275	EMC	xgb	Is known to be	QMEPASKEAQPLCDDPAGFSTFFVDDFPAPSEASFEAQLELNTPELFDNWIEWMRGTFNGQGGSGRALSEESNMAEHGLDWWMVG	3883.020538	2.396531204	0.485440567	4.936816917	7.94E-07	9.46E-06
													CCTGTGACCATA	0.670036229	0.241524211	EMC	xgb	Random arrangement	EPSNSPQDDEPYNTDMGPLGFTPIEFCHFWWDDMYQGIPPMDIGQEGTTEGQTASEILPMNYDSVGDDTFDQMLQLVDIPAWMFY	2563.093698	1.481670756	0.367154226	4.035554138	5.45E-05	0.000514231
TTGTATGTACAG	0.826851364	0.243605834	EMC	cnn	Is known to be	GGGGSAAPGECFDTVLMGELEAMLGHHSDKNPDVDSLEDNRLDLLSDDGAPLPDLGDLGFGFFAAGMDGSVWPMGAVCDQDTTGM	2380.406986	3.076254463	0.410099984	7.501230395	6.32E-14	1.50E-12
													ATTGATCTTGGG	0.83934367	0.245107056	EMC	xgb	Is known to be	GNDDVWPDDTPMDFCQDWWPDNLFDHTAGAKGFGKGDCWLELGLNTDLDLRAEPLDLDGLGMLMDWHALLPDLGPVGGASPNWEN	1271.856581	1.524570638	0.486393357	3.134439682	0.001721826	0.011985073
ACCGCAAGTCTA	0.899533559	0.248186901	EMC	Both of them	Is known to be	DTQSPFQFYNDDDLFGPVELESMTFPHVGLNYPPFELPDVELPPPAASDPPLPGVINSNGGFGHLGYELDWHRMFDCPEPLPSSQ	1924.158799	2.281281913	0.507083574	4.498828262	6.83E-06	7.19E-05
													CGATTCTTGCAG	0.608898928	0.250374722	EMC	cnn	Is known to be	DWNGIDILFDDPCGNIEHSLLEPSETAPTKASYFCATMFPLEELDQLFDCPEQTSPFDMNMLDPDMDGWSGQQLMDFAQDYDNGA	5863.041743	2.138178245	0.329232565	6.494431209	8.33E-11	1.52E-09
ATTCAGGCCGTG	1.075535235	0.255890949	EMC	Both of them	Is known to be	CPGGSSGANNALEFNIDLVDTHIWEDFCTLETTSLPGSPWAWQDTWEDELRMEPDHLMGLLDLEYPADLMPDSNAFELAPDAQPA	2727.814349	2.383112206	0.526351405	4.527606807	5.97E-06	6.30E-05
													CCTCGCCGTCGA	0.889816636	0.266667261	EMC	Both of them	Is known to be	PTDGADNAGFSTSWSPSDVGQGPWDGSALYDCLSGLMGDVLWEVVPELSDLDQMGLLMAETDPMLPAQTDEGMEPGNIEQDSNGE	1219.507193	2.190723058	0.70957249	3.087384429	0.002019263	0.013880394
TGAGGAGATTGT	1.093675198	0.2710033	MH	Both of them	Random arrangement	IFIDPPETHSCPEEPPIPPSHWLPIPDDLLDQDVLDWMGEDSTHDNAFDPWSPTFPNLADMSYNLPYFVDVEMCQFMEDSGPGWP	899.1035928	2.182703471	0.544946663	4.005352486	6.19E-05	0.000579058
													CGACGCTCTCGG	4.686639397	0.274115429	EMC	xgb	Is known to be	AEMDFFHLTMPQSGYPLMGGRGPQPRGALDELMWSAPPYGLDLNLDSPDTSASCNMLDQFLNDPEMDRAMCDEDLFMLLGTLEWD	72.6377251	9.41060398	3.344589759	2.813679602	0.004897802	0.030379857
ACCCACATCCAA	0.718279287	0.277580839	EMC	cnn	Is known to be	DTEDFGWEGMPSNDINGLVYDEDGFIGIPDVADYPTPWLTPMPDMDSILPLMYENIFALPNIGGSQEGHQTGATQQMHEQGPFYE	1606.858897	1.81728031	0.354491372	5.126444405	2.95E-07	3.65E-06
													GTGGCTACTACT	0.827400643	0.28182294	EMC	Both of them	Random arrangement	NTDFFNFDGECSDWEAWANTIAEPDFNTIYYPIESPEPEWLGQMDLPDVETAYAPFCSNNLMDSDPTPTGRGSEVEELRWWIHDC	1223.290926	2.453152364	0.360370525	6.807305795	9.94E-12	1.98E-10
CCGAGTGGGGCT	0.688587451	0.282567609	EMC	cnn	Is known to be	VWRAHIGSPSPFMLGEHQPLFFPMPDVDNDELTTYEESMMPTLNLLSPGSEGVGYAMDDLLEELESMDGFWYGSTLIDEETPWLG	5695.718253	1.316300758	0.37561303	3.504406538	0.000457626	0.003611457
													TGCCGATCGGTT	1.130064678	0.284327559	EMC	Both of them	Random arrangement	ISEIQHFLQQHFNTCDDYALEPELDVGDSSPGWEAPVQSASGDLSIQAMEYTLADFFQDLNMWEWPNPDAGSWTLVDAMDGDCHT	810.0614043	3.366390864	0.609827573	5.520233936	3.39E-08	4.74E-07
TCGCCCAGCGCA	0.884188333	0.285054981	EMC	xgb	Is known to be	ATILPIWADEPNLFTWAYTPRMEALQQTCATDISSAEMGLPGTYANEPSSEDFWGLQGPNPYTDSETEGWDTNAFWDILGNMLSH	849.5343651	1.484018786	0.527132835	2.815265313	0.004873698	0.030283245
													ATTACATCGCAG	0.846304373	0.290832309	EMC	Both of them	Random arrangement	QTWDFWDFWQGIGNISQEQEIDEIETWVPETSWTNPLHSPVAIPSHMPAPLVMDDLYLQNDLPPPVDDDFLINYPGWALEDINLT	1104.889343	1.8572555	0.394026443	4.713530097	2.43E-06	2.71E-05
CGATTTTACCAA	0.68176782	0.293505835	EMC	xgb	Is known to be	PDCEDLLQKPEPDQPPSDYPFPEDWGPCDSSKLETDSLMCDTSVDDLILQGLEHDPLLEMVTGGLGDTGYADFPDGEDLCLMIGE	2126.216361	2.053888869	0.564297247	3.639728672	0.000272925	0.002300372
													GGTTCTAACAGA	0.737498295	0.297840467	EMC	xgb	Is known to be	VMTDCEFLAFSSADEGPSSFVPRCDVLAYDLWPPPHTMFPNLHELCESLTDPPTQWEPPEVGEDLFDESMVAHNVFDLMRGDFAY	887.2641127	1.399483623	0.509677275	2.745823075	0.00603593	0.03661453
TGAGTATTCGGA	0.740718909	0.302635669	EMC	Both of them	Is known to be	QDQGSTLPDYPTFEDTISSWEPVWQECDQGWRGGSTAPDDFQGTSEHHPMTGITQPDMLGSDALDDFDLHMCGEWFAWINSHWMA	4838.185999	2.995752845	0.343560561	8.719722767	2.79E-18	9.53E-17
													CTATCGCTGAAC	0.671213483	0.302640813	EMC	Both of them	Random arrangement	DTPDEECPIAAHVVNSWHAEEHWGWDAWPPENETSWNTLFLGNGINPDDPIAGLDLDLMTFDWMLEMPDLWRMSQLSMSPTMDWD	4318.900939	1.700863478	0.395058453	4.305346373	1.67E-05	0.000167604
CTCTGTAAAAGC	1.303717536	0.313507356	EMC	Both of them	Is known to be	FDTWKSDLFTALCDDMAGFCEALEKSFDLDNWWAPEATSGAGQTSLEDIFLDSPGDHWGLEQAPVVEGGGSSLDQVMEAHAPSGL	309.6516881	2.051569964	0.753066141	2.724289213	0.006444005	0.038852176
													AACATCATCTTC	0.961064201	0.318525631	EMC	xgb	Random arrangement	AHDCCYTALCPHPCCEASGGASDFGDILTSMPYEPPLESDIEWQVYEHCFTPDGIYTLFDSEQYIDMGSVQEWLMPWGMDGNAEQ	2734.436204	1.884451	0.398470056	4.72921609	2.25E-06	2.52E-05
AGTCTTGCTGAA	-0.627394352	0.319126862	MH	cnn	Random arrangement	CCPNCLLEYAWIIDICQNNWDDWDPFPDPYEIIWMMLITSQCHDEGDRDIGRTCVVHWDDMLCADCENNDEMNMTNMIVYQNNWW	953.3182969	1.526672344	0.576406769	2.648602388	0.008082536	0.047348758
													TATATGGTCCCC	0.814198401	0.322057603	EMC	Both of them	Is known to be	SVSDYSVATSNGMSVMEEDGVDWFDDFDLDWLGSDALDLLDLFDEMPALGASRAATMSFLSWQDYMGSPVGNMVGGGVSPGDDLA	2461.809222	2.541314482	0.343766574	7.392558427	1.44E-13	3.32E-12
CAACAATGTGCG	1.161817453	0.326211185	EMC	cnn	Is known to be	IWDIPPLDCNWVGITDDSSAACGQELPGMELPEPMHPYPPTLHPLFDLQNVAPPDLLWLFPDENCQMWLDFLVDEGSAPCNGPMC	591.6430595	1.313529656	0.498521542	2.634850341	0.008417439	0.04890601
													TTATATGCGTCC	0.588641541	0.327793336	EMC	xgb	Is known to be	YPNNLLEDYWPLENIMVDDCRNDEDVGLSQQEPWTELIELTLHELYDFDVTAPEFPFEEAVSQAFWDLDEPNSYYQACGGSGVGD	3234.682381	1.241697054	0.349945585	3.548257517	0.000387789	0.00316099
ATCACTTCTACA	0.557961861	0.327909582	EMC	Both of them	Random arrangement	DGGPHCVCLPGACQMPCPEPCRTNFASQWALYDIPMMIYEHPPDWASLPSPQPQDSNSWIEDAATMLASDWSTSDFVDIWSILDA	3638.333877	0.977918067	0.289828883	3.374122192	0.000740515	0.005637468
													ATCTTGTGTATT	0.625604153	0.330816936	EMC	cnn	Random arrangement	IGEDTPPCDMIMTQMIEAPPSDGPGEFTPCNWRGSATDTDVPHSQEDFNLATEIMLDALMSNPQWGPNTNCFPDDMLVNLDISHL	2675.816032	1.056669974	0.265115837	3.985691636	6.73E-05	0.000627983
ACTTTGGGGAGA	0.976978052	0.335376699	EMC	xgb	Is known to be	VTDPPSQDTSSYNGPVLPEIPCGTNNCDLPEFVWNFAETCQLDLSSECAILMGEEGAFPGLHGQKYGDNDIWFPSLEGGMPGGTD	1600.044252	5.105784128	0.564110804	9.051030567	1.42E-19	5.66E-18
													CTATCGGGGTCT	0.7997343	0.336648317	EMC	xgb	Is known to be	LDTQPSPEAAEHVSLVPEDNYYTTDFDDVLKLLGEGLLDLPDLLQAPDWTLGIPEMVAQHQKRQDSNVSSQLDLLMDGGGDGPGP	4109.407625	3.287593373	0.564673805	5.822110652	5.81E-09	8.73E-08
CTGCAACTATTC	0.567200119	0.340247909	EMC	cnn	Is known to be	HPDMEVIDLPILIPEVTDFFDQDVAFTFGDDGPEPPTPWQTPSHCDLYDNNVDVGALDYLEEMTTIGMTFAPPVESGLMNMTPFE	5020.042545	2.234948084	0.461810758	4.839532309	1.30E-06	1.51E-05
													GTACGTTAAGTA	0.828811083	0.346536882	EMC	Both of them	Is known to be	TTPGTYDHDMYKLLDNIIFQNPPAFEDLSDLDALWMHGPVIGTDHDTWHDISEMTLEPAKFPAAFEGSSLHANFLDDLSNAWDGE	1367.714446	2.128566199	0.699472967	3.04310002	0.002341545	0.015853411
TCTGCAGGGCTT	-0.995673789	0.349490811	EMC	Both of them	Is known to be	APPVDPQKSDQAHQNLPEMHDMLWVDLTDTSSDAWGPNQLNDEFWADLFMMYDDLWPGGWSGGFGQDEYEMPCVMGTEGYPSDPP	1456.627299	3.051930118	0.911163471	3.349486908	0.000809614	0.006107224
													GACGCGGGCTCG	0.751155859	0.357076179	EMC	Both of them	Is known to be	ETCQGGWQHMTELWPYDIFLGEATEHNVTDVWTFNPWNDLSPDAAGLAAEPLSHFWDDSLNWLDQLELMEDFCGDGEDSNWLTDI	2091.555501	2.055959265	0.330405997	6.222524063	4.89E-10	8.25E-09
GCTCTGTCGTTT	0.55319048	0.360260723	EMC	cnn	Is known to be	STESNGEQTNEDLGETHLDYLCDTDTHDQFWTDHEFYFPPDSLDDLDLYSAPDVWGHFSALYAPGCPDGGAQFHEGSNPDQYWAM	5125.903758	2.465082427	0.397479536	6.201784496	5.58E-10	9.35E-09
													GCTCGCCAGCTA	0.475918939	0.362948388	EMC	Both of them	Is known to be	PDDQPGHPEPHASPPTTPGSPEPEPSHFPWDPFVYARSESWEPPLSSNGIFDIFQALEAIDMVDFMLPTEPQNWAPAEPQSRNFS	8362.731949	1.564790475	0.280764751	5.573315281	2.50E-08	3.56E-07
CTGATGCAGTCG	1.164383598	0.366500604	EMC	xgb	Random arrangement	NDSNFEDPDWAIGMPDEYNCLGSPFMSEEYTGSDREAYLADLDDLLGLWDFMDEDLYVEEMAGLPEFEPGTNNHIWFTDMCAENP	745.957691	1.532250368	0.495037927	3.095218132	0.001966682	0.013596756
													TCTTTTTATTGC	0.539307844	0.37400568	EMC	cnn	Is known to be	EPCPETRDLDEWIDDYFHEFMAITMDVPMLPPTAGQTPSLDGLFETSENVSTEELWFLGGGTPYMSMPSSILDPWDHIGLGWSMD	5904.427796	2.02845355	0.366143922	5.54004431	3.02E-08	4.27E-07
CATTGGCACGGT	1.318288602	0.375368086	EMC	Both of them	Is known to be	FNCDGPDTPPIIDQITEILEMCLQGDVSFESLDDLVLESLDCFSPEPSLDSMWCDVNDSSIVPEGPSEGFMNSEIVAAPQMDRHD	419.025239	1.617145476	0.577794138	2.798826381	0.005128871	0.031694118
													AACGCCTCGCCT	0.582258975	0.377104419	EMC	Both of them	Random arrangement	EAESWQPSIIGEPMAEIMDWPCPQEACCNCSEQVNMGSCCTSFNLDPVEGHSGPDIFLGLDNDEVEELFDWHVESPNIMPPSDGP	4596.953595	1.319788248	0.443791564	2.973892151	0.002940484	0.019430719
GGAAACGAGTCC	0.716344302	0.377104419	EMC	xgb	Is known to be	GGGGSGSMPPTPEDQGPIWWNPFADYTDSDLPSGPMRVTSDDAILDFDALDYKPDPPCVDFQWYDMTPADASDWFDLLMLFDEEP	2425.819228	2.113032256	0.457828863	4.615332116	3.92E-06	4.24E-05
													TCCCGTAACCGA	0.694900841	0.377104419	MH	cnn	Random arrangement	DAQWPPPTEDMDIHMESWVPENSFDEWHPVDWEYAAETSGMMAKDMLYSSPEDNGFGFLHGIMPSPITDWNMEFGIPEFVQTDQV	4242.192157	2.029380968	0.380251696	5.336941268	9.45E-08	1.24E-06
CAGATATGACAG	1.340066593	0.388840489	EMC	xgb	Is known to be	DEIFNETLAMGLLDYLDDFDGDWPLSLPDSTPEVDQIFGCRMPLSLNDASELKDLCWTGPPNDEGDGPGSWGTIPINVDPYPMGS	450.644316	1.841726853	0.567732744	3.244003224	0.001178624	0.008552359
													ATTCCAGTTGTG	0.53200409	0.393177312	EMC	Both of them	Is known to be	CPGPLPHVADLDILGLMFALEEYAPCAECDNFSAAVTLVDSSGLWDSDQDPARDVPFDGSFLDWIMEDFDVWPPSIGHEEDSALL	3607.455516	1.183901876	0.429118298	2.758917251	0.005799322	0.035352323
AAGGCATACAGA	1.023927198	0.394949124	EMC	xgb	Is known to be	NWFASSIDLTAHWDLDLPSDDEEEEGAFNSGSTTEYLLDLPDDDDLLAITWGDPIGDELNLDASPPMTPSEPLDYFLSTFHGPLP	798.8873511	1.82641535	0.441758917	4.134416487	3.56E-05	0.000345133
													AGCATACTTCTC	0.731642406	0.394949124	EMC	xgb	Random arrangement	DMTSGQPLRLQNINHGTNEIADEWFPNIEPDCVWNLPCDDSPSPAWGMPTQLWSIWTCSEMHDSVDSFDMDINLFDPNAAVSPPD	1475.223784	1.254217673	0.390811404	3.209265804	0.001330744	0.009544382
GAAAGAGTGGAA	0.684581719	0.394949124	EMC	xgb	Is known to be	DGTPNDDLFANITQNLPWHHEEPPLNALFDTSATQDSSMAWDLWLDSPESQGCVVPLGGQPTGGLLPYMNIGIDCGDIFDLGGDG	1486.64407	1.646946258	0.512511176	3.213483597	0.001311353	0.009432605
													AATGACCTTGTA	0.503838558	0.395574142	EMC	cnn	Random arrangement	HVMPNDPDMDNETICEHIQVYNDYQGYDHQYHNDPLMDTPGSSLQGFRDPGAQIEWVPMDYESFINWLDVPAWDPFDLCSPLWYD	8101.505131	1.462376599	0.289517054	5.051089668	4.39E-07	5.38E-06
CCCGGGTCGCAG	0.692624786	0.395574142	EMC	Both of them	Random arrangement	NMDEDPNTDNEWDNPWIGPPNNWHIWEDLQCSTPFQLSDYDKECEFNGMADNHLAAQICDDLDWAPFMQEQEMWTEPLQDEQGGS	1261.232989	2.08144046	0.578778189	3.596266234	0.000322817	0.002684368
													TCTCCACCTGGC	0.869250634	0.395574142	MH	xgb	Random arrangement	DDILFNMYEPANPGSVIHNELGGHNPDLESNTEPDTPIEWTVNTGPLLNDCCEGYNLGNDMQHEMLNTVPIPWFEGCNVDDLPWV	919.346268	1.309547605	0.48728163	2.687455313	0.007199874	0.042939318
TTGTCCGGCTTG	0.533106781	0.395574142	EMC	Both of them	Is known to be	TSSGAAQSTPESLYDEVRVEVPEPHQDLPTNLTFTTFDGVLVCDLESIINSMLMPPMQLDANFQDDFVTDLWGWGDPDGPDEGAP	3028.166948	1.675309937	0.422197331	3.968073257	7.25E-05	0.000672457
													TGCAGTTGCCGT	0.80864563	0.403004453	EMC	xgb	Is known to be	DFDDFQELLCADTLWPDLLEGGGDVGGQPHVCPMGPFADVPMTDWTSGLCGHSQLTCCDLSELLSQLGDSSDMGPFAPGDSCYWA	1216.612326	2.491532779	0.484892681	5.138317978	2.77E-07	3.44E-06
TGAATCCTTATA	0.821400683	0.406486341	EMC	Both of them	Random arrangement	GNAMENDATTCVTMCTDEGPIDNGPAMPADALDNPSDWSDFGTSSAITPDNYWSDLSFEETIFNRMAIEPLDWYDILVGLMNGPQ	967.2924678	2.107409705	0.578936827	3.64013759	0.000272492	0.002300372
													AAGCAGATCATG	0.631251013	0.407576383	MH	xgb	Random arrangement	DAIPPTEEEMRDTHNLPAPEEFSMDEQAAIWGSGTNVTMPACALNFPDWEDMMTHGSLFVADTMEVNEEELDCLLQVAEPLCYRH	2620.498121	1.212503358	0.343635038	3.528462539	0.000417981	0.003351965
ATTCTAAGGCCC	0.824155205	0.409397986	EMC	Both of them	Random arrangement	FPPEDPPGNACLDMAPHILGPNGCMPEGTPWPVPFPMSDETNQLGLEFCDLDIPIEMLFDWPHDIEFWWTEFPNELDIAWDPNMI	940.028485	1.559900617	0.501885885	3.108078278	0.001883082	0.013070803
													AGAGAGATCTGC	0.782393593	0.410406656	EMC	xgb	Is known to be	NDDYFCADWDMGNTAEEFFNIYEMFDLSHLPPIDSTAYPVPTSLPSGPSSSDGSAPSFGWIYGGTDMQVQEWTAGQPIGALNPTR	2050.522398	2.26188107	0.388792672	5.817705002	5.97E-09	8.93E-08
AGCGTGGCCTAC	0.800111231	0.410406656	EMC	xgb	Is known to be	LSDGGTMDLDHSSLLWLQDLPQATIDLPPTDFYDGLMGHSDWSTGDFSEGYTPHMHDELCLDDLLSMTTSESWGAVCPPPPAKRP	1293.965525	3.757718153	0.631379418	5.951600645	2.66E-09	4.13E-08
													TACACCCCCTGT	0.505717901	0.41135458	EMC	xgb	Is known to be	SCNWSREGRMTPSDYRHTYFDDQHALTPLAHLVSSAPAQFDCLDLIDWPDFGDLSDKPYGMGDSLDFEAIFGITGHEMDWNQLWA	4460.966415	1.56046783	0.399559087	3.905474511	9.40E-05	0.000855166
GTCTTTTAAAGA	0.64033749	0.424048039	EMC	cnn	Is known to be	DDPPVGQWDPTFYDDTDAFLPPLDHLENWGFDIQENMYLFFQSMFASHDDLQTPSPNVYDQTPAAEWICQAASPQEEEGNNPYGK	1445.969136	1.508417592	0.413503468	3.647895866	0.000264397	0.002236093
													GTCGCCATAACC	0.55631528	0.429033019	MH	cnn	Random arrangement	HGKNTLMWPGHCGSTGIEPASLELPFDGTYNALPHIEPPHIDGWLPHSLPEDSAALDWMDILEGMDFTPTDWFNLNDGPTGTIWN	6641.616251	2.458771297	0.298023835	8.250250497	1.58E-16	4.72E-15
CTACGTACCTAA	0.760742326	0.431376453	EMC	cnn	Is known to be	PMADGGCSRHGCLWHWEDALLPGYDLGTLDEFLDPIDLGDLWKTIESGAGDFGQGDMMDPSDTWMQAHDSSQCTEHTCALDDPVG	1821.458871	2.978456683	0.493862186	6.030947027	1.63E-09	2.59E-08
													TGTTTCCTATCG	0.62101963	0.43519224	EMC	xgb	Random arrangement	PEGPTQPTHDDEYATSSAHGLEAHQDGAEMDPCMLDWMDYVYPSIDDWMCDWMHWFEAPDPAPNSPQMCMGTNCNLQWYPDHCDI	3984.753622	3.510246194	0.508193364	6.907304275	4.94E-12	1.00E-10
TGCCCGCGCGCC	0.595738791	0.438213467	MH	Both of them	Random arrangement	ADDLCDIDDTNTKEDDDWSAFDLGVYPDWGWPDPEHIQMHFQPFHTNFIEDQHILDHVNNPWPLDNGAQGSAPQLPEMLWEAWYA	4384.221394	1.156084147	0.40038201	2.887452778	0.003883749	0.025029727
													CGCTTAACCGCG	0.748777284	0.44024373	EMC	cnn	Is known to be	ADDATTWFDMLPGDLLDDFDLTEGWAAMPWAGPANLLGQLNLDDFDASDISMGAFFSESEDAATVESTGETSHPHTWLYLTTQQW	1996.049847	1.913346409	0.680291431	2.812539337	0.004915201	0.030449671
CTGGTTTCCCTA	0.66257801	0.44024373	MH	cnn	Random arrangement	QNPIDMALYNADFMDIFDTIPWQEGELFNLATDPGFESYQPEIIEQWTNVPTAEPLFDMCDLNHLAQQAQNTDNISQSSFPSPCQ	1509.178168	2.716887112	0.42971678	6.322506449	2.57E-10	4.51E-09
													TCTGCTTGGTAA	0.817591229	0.440687506	EMC	xgb	Is known to be	GADTLMVSHISLGQEGSHPGSEGCLCAAPSMDPEEALDFFPPEPLTSDGAFWDFDCLRCNDDTMMDFPVETMFTDALGCDIGDGT	980.0817897	1.640931537	0.582488824	2.817103897	0.004845885	0.030225608
TCGACATGGTCA	0.494615077	0.440749324	EMC	xgb	Random arrangement	LDLSGLIPPDDNYQHCNCYCEPCKPMFCFTPQDPWGTDEDALIDSPWFASVAEDTDYYNGDNMFWDGFNPMEGVLDHILDFHQNE	2215.608345	1.421260747	0.431078609	3.296987413	0.000977279	0.007239752
													AAGCGCATCCCG	0.640697077	0.448140479	EMC	xgb	Random arrangement	DSIVGDSSHEQEGMAFRCPSLSHPWPEDMFDPSQYNDLDLPVIDFPDIELKSMERPPTMLWMHSEGYGPEAMYTHNSVEDWLMQV	1249.193839	1.657353959	0.48559224	3.413056932	0.000642385	0.004958974
CTCCCATACCTT	0.746566694	0.448140479	EMC	Both of them	Is known to be	DYGGDALFPADVSLMDLYAAEPVDIDLTDTDCFDDFDLDLQLKTEDRHELLGMLDNAAYGWDGIPDRGFPDMSSDMTDWFATNTS	1739.3264	3.117394088	0.584439644	5.33398807	9.61E-08	1.26E-06
													TGATTTCACGCA	0.48462041	0.448435646	EMC	cnn	Is known to be	VAPATPQGPYNQHWDEVPDWPVFDHQVPCDFPVPTWPNCLTTLGELNNGLTDLDDLMNGSPNCMQDDTASPEEQEPDLYFYFALS	3093.728803	0.885526599	0.259134315	3.417249468	0.000632573	0.004890844
CCCCAGCATGTC	0.488808601	0.448770742	MH	xgb	Random arrangement	PGHNPSNRDDFANFFNDLNACEAEISQHNWIVDWDADAWTEVLRTGPEEFDIPSAVWNMEWDDVLWWDCEDNLDSPWWNQPCDGS	5748.993938	2.567401676	0.357204047	7.187493251	6.60E-13	1.45E-11
													ACTCAGTTGGGG	0.559510895	0.451501894	EMC	xgb	Random arrangement	ELNMLEMPQDQPGAPNHTDQCEFADPLAHSQIAIPLDWMGWFHPPPSPPYMDHLNPNDYTEPWDLAWDYFLPLNHMSVPEDGADD	1683.180327	2.733334883	0.394880669	6.921926294	4.46E-12	9.12E-11
GAAACAACAGCG	0.583596123	0.461128641	EMC	Both of them	Is known to be	MRPSPGTLFDMDTLFNMAPEDDEHLYLDLGDLTASDTVNIFDGYLAGSTCLDEFMMDMLGFAALGDMDTDALGSPDGNFPEPVGH	2351.244826	1.59931903	0.345584056	4.627872734	3.69E-06	4.00E-05
													TGTCTGACCGCG	0.7896687	0.461128641	EMC	xgb	Is known to be	LNLDDFCDWPPLGDQNENEDVCMCPEPPDAGCYLDMSSSDFLKGFDLDSLGGSMDDLIDIAAHWNTIQEGWSEAHSPELPSVPEP	1043.18878	1.764160518	0.577816228	3.05315156	0.002264515	0.015416124
GCAGTCACAGAG	0.52325986	0.469091288	MH	cnn	Random arrangement	SCQLQEGAEQWRYHTENQMDCEHPVVTHEFDPIFVNPEFPSQDTRLSHEEDLGDPMYMPPNLDMFFYAWDFDYAPPTEWMTDGWW	2402.84172	1.107275713	0.315685764	3.507525009	0.000452296	0.003586525
													CCTAAAGGGCAC	0.87504306	0.471497319	MH	xgb	Random arrangement	YDVNESWTELTTFWDEVSEILLAPSGQSHADAHEEFHPLFQADGPAETPQPVPCVDEEWVWLHCNYPMAWFEVGPPQPEAGNAMD	668.3473905	1.681326715	0.557797196	3.014225829	0.00257636	0.017254646
TGGATCTATGGG	0.501950942	0.477295073	EMC	cnn	Is known to be	DTDYFDAMSWFDNILAQLPQHGPHLPEHAYVAPPAFDPVMAPRRGWFCEDLLASPGLSGEDLATIMEANESVFPWEGLWCNTTDM	3273.266621	1.029318627	0.291793533	3.527558055	0.000419412	0.003358004
													ATCGACCTGTTT	0.476148656	0.47845634	EMC	Both of them	Is known to be	TIPQYGPNIDLTCDTSCGELLPPSDALAPVQGFEVVSMIEGDIIDELLWETDKLSSLEGPTPLADPWVWTDNDELRELMGARNQW	2710.254757	2.043372314	0.470796903	4.34024162	1.42E-05	0.000143953
ACGAAATAAGCC	0.538780603	0.479433422	EMC	Both of them	Is known to be	DAQACGVTEETLETVTDLDFPEEGSVISPPFEFTPAEHTTAPLGLWFSAPMPAPELAYLYSDVALGMVNMDIDFEPWHYAGQELP	3350.105822	1.461849145	0.370834483	3.942052892	8.08E-05	0.000745589
													GCAATCACGTCG	0.625319263	0.480874952	EMC	Both of them	Is known to be	YDPGLYHGFPPPADETQWMDHIFDNSIPPDWWLTAEAAPSAPSSHDLLASGSLVPSNDRPQGDPAVWASFQCWLGPDFGGNPQMD	1871.341006	2.17792776	0.476530013	4.570389482	4.87E-06	5.21E-05
ACTGCGCTCGCG	0.62838198	0.486493981	EMC	cnn	Is known to be	YEERLEVKQETMPVDSDGPACELWIDFDFDEFDTGLALLNGDAIDGLFSSDVTPLLRDYNTDAEQTKHDWCLNEEINVEPWGPAP	687.6330456	2.230130637	0.70276327	3.173373926	0.001506783	0.010668026
													ATTTTTATTGCT	0.746227409	0.486493981	EMC	Both of them	Is known to be	WDDMMTSTPEERLLWSCMDPLAIPLLGAPDQDTTQEMLAPYPMTNSQPMSTGDAVTAPDELETLIRHWCALEDFDLGLPDPLSSG	4217.380528	1.758442634	0.304074947	5.782925075	7.34E-09	1.09E-07
GTTTTTGCTCCA	0.492067442	0.487434115	MH	cnn	Random arrangement	TMNQARDNIAWSCASPESEVLVPGDLVQHPCPWITPDLSDIALYDPITFDESFDPYFIDAWYFSQDDGDVGTMFIMGDDIEHMNE	3348.337306	1.041595761	0.308789872	3.373153902	0.000743124	0.005648655
													GGGACGAATGCC	0.887001837	0.491580914	MH	xgb	Random arrangement	NACTWHPEMDQLCSQLWTYDDVYFPSFDNTSDQGMELQDAMLDPAHIQWIKEMDQLLVESDYEVAMDLQDDFPSFGECNDFGDSE	1315.913761	2.458100118	0.606184126	4.055038746	5.01E-05	0.000476822
AGTGACCCGGTA	0.420291871	0.494883255	EMC	Both of them	Is known to be	QQDLVIPTDWLMPDYILCNEPDDGLDELLGMDYTNIDHLLTPELRDLDIPLVPWGNGDPQVHEFLERSYAHFGFDGMFGDADFDG	5893.191024	1.745505741	0.288160087	6.057416756	1.38E-09	2.23E-08
													GTACTCCTCCCA	0.44790399	0.501400523	EMC	cnn	Is known to be	VDTASDMFNLCKQPADNDLWTPYCWDHMDTAPPASNAHPAPTEFSQFNEDDDMLCDLFIAGTSQAGFDLDDWMSMYSGITCREPV	3531.141461	1.161081793	0.252877262	4.591483561	4.40E-06	4.73E-05
TTCTTACATGCA	0.620904702	0.501400523	EMC	xgb	Random arrangement	PFDIFQEVNPHPCPPSILMQPDPAWEEENQNDIIWFSGDQIDFPDMMNWSDPDVPEGEFHDFPPLTSNMYPEPLSWAAPPPELSE	3480.877895	2.450502761	0.388266836	6.31138829	2.77E-10	4.81E-09
													GCGCACATAAGG	0.805295033	0.505806941	EMC	xgb	Is known to be	DDIWWPMTHNWDDTFQGLLEYEASIDFDTSFPPMPSDSEWPLPDVMVDPIAWEPLGKLWNGMFTDTPEDGAESAAEEPKDEAECG	1461.270907	2.328405607	0.523817314	4.445071872	8.79E-06	9.15E-05
AGGTCGAACTGT	0.479654857	0.511497983	EMC	cnn	Is known to be	STCHPCHNGWTIMEPGNMDTQESEADEWGFACGPLWGSSGISLDSDWLAANNMDQNDLGSDFAYYMEAESMNLADGSGATGPIWE	2032.31707	1.892425845	0.544238015	3.477202607	0.000506675	0.003975285
													TGTTCGCAGCGG	0.4496138	0.513182699	EMC	xgb	Random arrangement	EPSKPMDTDGDAEHHCTVVEVPAFWGADPAGAQLTFDLWPESLMNMCSEDFDVLQPQGAGMIPLDGWGFNEMFQDYIGRSHQGSY	4504.344563	1.165227509	0.328805876	3.543815953	0.00039438	0.003198935
CTAAATCCGAAG	0.735004791	0.516192204	EMC	Both of them	Is known to be	CEDYLSTLVPPGRPDEHGPSSRGFLPQFDMNLDPGFDFDLGLDMALDDIDRLLCFIGREMPFQTVTQSGSAECNQGIPQQATHDV	1026.179351	2.007493398	0.423907039	4.735692535	2.18E-06	2.45E-05
													CCCTCCCAGTTT	0.490685994	0.517655712	EMC	xgb	Random arrangement	EAAQMSEAAQWWEDLEPLPLPLDYLTYETFDMCQGTYQWIATPQEPQYNEQIPFEVHIDRHQPFKEFYWPEPMASDDTCDQGDGP	1531.059167	1.070379084	0.369502782	2.896809271	0.003769789	0.024484747
CATCACGATCCA	0.521893436	0.520105265	EMC	xgb	Is known to be	FVMDDGDAFDFDSIPGDDAQLPPLSSDELVICKLDMLGSDTLTAEMLDKLHPGGVDTESNDSDVWFSLGDLPDLGGWCSPCPMTF	1838.767678	1.185178814	0.420695944	2.817186215	0.004844643	0.030225608
													CCTATTAATGGC	0.421465161	0.520105265	EMC	cnn	Is known to be	PDDIYILVPSVSNSPEMIECPLFPDDHQNLLQSHIDPLLATGSMLDMSQEEGLRNDAMAMFMNYLDHADWGLMFEHAPDSQESQA	5447.480258	1.343014726	0.271644606	4.944013967	7.65E-07	9.14E-06
CAGAGATGAGGC	0.52229398	0.527985879	EMC	cnn	Is known to be	PTPGDHFEGIYDDLFQGLAENEYVFDFPEPVERPERMNSNDDIIDHLSSADDFPLLWLSPHPGGGDDGGKYPGQGYAPAGHDWTP	2041.756366	1.388521168	0.505803384	2.74517967	0.006047778	0.036641548
													CCAGGGCATTGT	0.725203123	0.532320097	EMC	xgb	Is known to be	FDNAIPQEPHWWEGMEEGSLESFEWEGPNTFGGHGSFGATSTDPLLWLPQLNDVSSVLCETAEPHESFMNYLGEEWSAGRAAFEG	1131.014928	1.394588626	0.518693741	2.688655203	0.007174048	0.042836844
GGCTGTGACGTC	0.474397244	0.533925071	MH	xgb	Random arrangement	TDLFGILADVEGGLDILPSQLWPTTPINDCPPLFMHDMTPNMTPINETLEQPLETWDVENCMQRWHHMPEREWLDYEFRMCGDMQ	2643.385961	1.309379549	0.3420076	3.828510098	0.000128921	0.001145043
													CTTAAAACCTGC	0.571337367	0.54491886	EMC	cnn	Is known to be	SIGDPPPGAHAPVWLHEPYDHDCNAPEDPWEEDVSQTTFDDFLELLLDSSPHMYFPPIYFMNEELVAEPGNGQPGDGACPPYGGL	2956.260764	3.350985019	0.524309362	6.391236289	1.65E-10	2.91E-09
CACTCCACGTTG	1.194002952	0.548467011	EMC	xgb	Random arrangement	DPLEFSELAMGPKDADCYELYNDWIEAHCATDPPPSMQPEGQLWDVWGLDPPFTVDPLFAEQVQLEPWTLMHPGNVDPLCEEDWG	713.0290349	2.761047043	0.664263402	4.156554514	3.23E-05	0.000315197
													AGGCTGGGTCAG	0.412448673	0.551297144	EMC	Both of them	Is known to be	SPHGTAMDESIEGLTELPEGCNPCFCCQPLPPPSAFGPTFSTKLWQFASDPNLDAHMSGLPAQEEWYNDWILQPDFDLTLQGWDA	3959.763624	1.444716081	0.323521936	4.465589247	7.98E-06	8.33E-05
CTGTCTATCCTC	0.68414504	0.556104311	EMC	xgb	Is known to be	DPTDLDMLFYDIFGPPPSNMFVGSCERSDSEALLSIPDMMDITPLGASDDALGFGWGLDEYADPQPSGAGLYKLEGETSPTSVPP	2064.634025	3.088389064	0.362121204	8.528605979	1.48E-17	4.80E-16
													AAATTTCGCTAC	0.686578388	0.563600128	EMC	xgb	Is known to be	EECELGTADALLDFDITMWDTEEVFDRVLDMIDQDDQSLWDLFDVEPDDFEPFDLDKHIGGGMTGLDLSMNEAHSELSMLDMLYS	1752.688428	2.303595644	0.445667046	5.168871391	2.36E-07	2.97E-06
GGTTTATTCCAG	0.454753969	0.563600128	EMC	Both of them	Random arrangement	VPAVHPWVPPMLLHDGVIPNDAGPDFGSDILYPSTPEQDETMWLEDWNFWECLPLISELFAMPLEIEQAQSMPADAGTNVYGDLN	4350.915511	1.235546868	0.364659185	3.388223633	0.000703469	0.005405258
													CTTCTTGGGCCG	0.588042659	0.568204343	EMC	Both of them	Random arrangement	TWGAAPKPGMQELWCGLCEGEEGLGQLPDGFTTSEWPPATMEQQTCLDPSMTWGGDIFFDNNMLGPASEWQALLEEYVFNFECDQ	2364.663531	1.806509486	0.348731181	5.180235044	2.22E-07	2.81E-06
AACCATATCTGT	0.582508759	0.573131202	EMC	xgb	Is known to be	GFPLNDIWASSYNPGEEFFPIVDEEALAHLLEANNFDADWDKLGEHLSDMPNDPFHDPGEMPEIGAFDLFNPESSGGDGEGLSGS	913.3142125	3.238256078	0.515946477	6.276341098	3.47E-10	5.94E-09
													CCTTTACTAACG	0.641733335	0.578664818	EMC	xgb	Is known to be	LSDDIPWSWINFDNFDVVPPWMMSSWDTDAMLDLAATALQGPGMSAGTDTPPPTPRPQWHNDLWGADPEAELVFLPDATEFGNQS	925.2193711	1.180834551	0.39989234	2.952881147	0.003148232	0.020720631
TGTTAACACTTA	0.518494674	0.586552639	EMC	cnn	Is known to be	TPEPFGQPRWTDQMQDIQAIESITDYSVDNLYPPSFLLPTLAEEIYDLDDNAPPDNLVNPGMYLEPLNDAFCPYNDFDLSTFWLA	2098.168029	2.440310094	0.475518632	5.131891639	2.87E-07	3.55E-06
													ACGGTTGCCAGC	0.358892172	0.587156677	EMC	cnn	Is known to be	DAPDPPLCVSYNINAHGSTGQILSKRNEELMDDPVQDPEFDATLLLADEPDNQPFLTMLFMNDPIDFWFEEMCMDAWGCDGGLNH	6086.873006	0.880501445	0.331188106	2.658614333	0.007846272	0.046320626
ATTTGCTATCTA	0.537478905	0.587156677	MH	xgb	Random arrangement	IATHDLWTRAPEQFDLWDYNQSDYDTEQAFLGYENPTLSYDILTPWMATQPAIHDGQCEGASPTMIDEEWTLAPPDHSHNDCRWR	1423.144353	1.25254004	0.321066297	3.901188169	9.57E-05	0.00086727
													CTCCGCTGAATA	-0.464349579	0.587156677	EMC	xgb	Is known to be	TDLDDLMYSPSLSDENTDWFGANNMGKDWTQSEIEGLLDLPDDWLAPAMLPDLKVHMSPGPDWGTPDDGQKGPPSTDHSLMDTCG	1758.099737	1.689370267	0.556984441	3.033065455	0.002420831	0.016323317
AAAGACGCCTCC	0.724836603	0.594869291	EMC	cnn	Is known to be	GDGQPAPAMAKPMPLDLGDTISAAEAGASHGDAPACPGFQATAELDFDVLGHLDDTLIYAKMFQGELLGEIGDIDVLALLDQGLQ	1068.378529	2.215224675	0.398030607	5.565463149	2.61E-08	3.71E-07
													GCAGGGTTACGT	0.459355652	0.594869291	EMC	Both of them	Random arrangement	LMDDPWDLFNNLDELFTDKEHPAVCELGLPPPDIGQTAWPMGTPRNPHDGVSTYYSMVGPGLEIEAFFDEIPNTSDAFLNDCWCF	3153.706186	1.143602058	0.337742734	3.386015285	0.000709154	0.005440509
CACCTGGGAAAT	0.519044771	0.597582565	EMC	xgb	Random arrangement	AGDIAWQDATADESDYGGNCFDMLNVNPEFFQPDPWCVSDSEFWQFWDLPPWVNDDDIQDLMRNNMMILGEGLHDADGRSEMDVQ	1456.77916	1.987511352	0.509145995	3.903617763	9.48E-05	0.000860178
													TTGTGCCCTCCG	0.513352359	0.602987999	MH	xgb	Random arrangement	TQTGQASCTGTWNSVEDIWPEEEIEGPSTPHSSHYADNRFAEGLAGSNAMADTCIVSVGSGYGFDTIEELYWGLDLFSDQDYDAA	2464.705828	2.018713725	0.645995143	3.124967343	0.001778248	0.012360445
TCGTTTCTCCTA	0.416582288	0.605499363	EMC	cnn	Random arrangement	EGANDCTCAPGCGQPSRYSPFAPEHAYQECELPSFPTLDDYDWMSIMSPPTHLDLQGCLMAMLEWDNFSDLPTQYQQWEWHDMIE	2290.179506	1.2532724	0.314851906	3.980513942	6.88E-05	0.000640614
													TCTCCATTTTAT	0.404398049	0.609175322	EMC	Both of them	Random arrangement	EVQDPHTPPDCFFGWPTVPNIDEYSWEWESNGENASLWHELMEHSDSPRPTLGMGTPHTFHIFPLDEFMYDTGIQDMQTLPPFDF	4117.194902	2.113339695	0.317496939	6.656252188	2.81E-11	5.33E-10
CTATGTCACCAG	0.439671912	0.609813774	EMC	cnn	Random arrangement	VVDDIISTTNRPWWMDHEETEHNGEWNLPEGPNPPTPSPWLHSEENSSRPMEQPRVTWALDDLVMTNDMWAPCIGLTTHWDWGGI	1125.62551	1.423349259	0.482420339	2.950433768	0.003173281	0.020857797
													ACTCTTAATCTT	0.727098987	0.611523779	EMC	xgb	Random arrangement	EGPVEPTWSLTCSEHECSDDTTEQCDAQVWFEDPREFSASFNEMPLPQFAYESWWEEMNHNDDPIADIHLIWPWGDMWWEGLSDQ	751.4002355	2.675695402	0.752564648	3.555435948	0.000377353	0.003081081
TGTTGTTCTGCG	0.335052785	0.621645339	EMC	Both of them	Random arrangement	WCNYSATGASGSGQNVECEYNEHLYEITAEQHAQPNPWPTGPTGQELPCTLWDDSGWFQDVMFDTFWDMTLDDLLQPVMPSWFSG	7473.753033	1.708689576	0.272519429	6.269973424	3.61E-10	6.17E-09
													GATCCCCATCTT	0.422459121	0.627793198	EMC	cnn	Random arrangement	KVAPIHQMFTYGSVTSSPVNDPYIETEFDSDWMEPMRTFILHNTDMNCLPNPEDTAAAMEQPEDWIMDTWFQNWLNGPGNGLPTN	2990.843163	1.548219668	0.252155543	6.139939049	8.26E-10	1.35E-08
GTCCCGACGCTG	-0.922991339	0.629315335	EMC	Both of them	Is known to be	ATLHSPAPPSMWVQGESEGHDPEHEFTLHADDLSRFDGGSILGSIIDELMDMDVFDGPAKSTPPNDWEWMAWGPSFTEWQSHLNF	1048.226493	2.182864294	0.486769808	4.48438719	7.31E-06	7.66E-05
													GGACCGCGACAG	0.498091748	0.637237004	EMC	xgb	Is known to be	GDLDDLPDENRWSEFQGLLETLDDFQFPQPSEPWHSTPAESPFVEDPYDLEGDTPYHDVGECHWNDLRIMWDICLFEELGHMTSD	1041.382859	1.36725963	0.428088375	3.193872366	0.001403782	0.010010276
CGGTGCACTTTT	0.569547115	0.642558936	EMC	xgb	Random arrangement	WGESSHTTLIDLGYQDLPPEDEYQPWHEFPIVDFGEQDTPWDWQKWDCDIDTSNACSMGALGTSCWSDAWEFWEELDLTTPWPED	3153.085123	2.517532626	0.539279043	4.668330165	3.04E-06	3.32E-05
													TCTACAAGCACC	-0.430124568	0.642558936	EMC	xgb	Random arrangement	APPIDGSSTMPAGLEDFISMPCSPGVLDPFFSYTANRTSGEVTGDESLEFELLPIAIEQIYCQEDWPDPFSQYAESDTPSQFWAF	3415.574966	1.289785309	0.366530683	3.518901335	0.000433338	0.003452769
GGTCGAAACCCC	0.947894869	0.65068702	EMC	Both of them	Random arrangement	VGLMDTTTAPDLGAVFYDFNADDYPVQPMCHMVDNLAQADMAELKWWTFSTGAALDSIMDQPDWSQASLDPPETWAEFDFSFDLD	568.9482384	3.10932146	0.618749544	5.0251697	5.03E-07	6.14E-06
													TCGTAACTGATT	0.413853462	0.65068702	EMC	xgb	Random arrangement	GVPGGDSTQGQITMDADPQEYQHTNSHNYGGRLAPAQIDPSATTHDWPVIDDIWYEPALRLLPLDWFGEDPWVVGHDMQMDTLPL	2982.678442	1.47529963	0.34817153	4.237278185	2.26E-05	0.000223361
CCATACGTGCTA	0.389013072	0.65208549	EMC	Both of them	Random arrangement	PYDDLSPCDGILPFDPMGMENDNTLGEPWPWSLSERPSEICLWVNDHVPGTLQDLVYAENIDNMSFQDLDWMDLHSPWTAILGDE	5527.878792	2.081086731	0.377276943	5.51607186	3.47E-08	4.83E-07
													GCCTGTTCGGTC	0.438818965	0.65208549	EMC	Both of them	Random arrangement	PYPIVGPGSPPGLEGVHTSAQPDHWLSPLQDMPAVPTHSAVDTTIWEPEWSLPAFNHYAFYPEDSWEDWVDDWNIINFTMLETNF	3418.410324	1.091649286	0.310365889	3.517297889	0.000435964	0.00346812
ACGGCCTCCACC	0.548369611	0.652721004	EMC	xgb	Is known to be	MAYDSPTVPLNFDEQLMEEWFYDPQLDLGPDTAEPPTPNGEPSILDIEDLDVYMPKDCPMEIALLDDFYLWDARLLEEGGGTPPP	986.0036467	2.698865118	0.455479767	5.925323825	3.12E-09	4.80E-08
													CGCTCTCTCTCT	0.478305757	0.659405851	EMC	Both of them	Is known to be	SDSWLMEDPLSDMFDAFHDLLELDVPVSQLYGLGDLSPTLEHLESALSEAFTWDPSSLSDSGGGLGLWEGGMPEAPGELDCAGFH	2085.10064	1.794590585	0.553343567	3.243176014	0.001182052	0.00856469
CATATAAAGGAG	0.448710241	0.659877615	EMC	xgb	Is known to be	NDTDGGASHYAGGDIFTPTDVLLHDSNMHPMQPDDYAFMEIPTWMEDLGIDLYAELDAPGSPEPPHPPAPPAPCTIREYFEDVGC	2145.281172	2.380842227	0.500665033	4.755359512	1.98E-06	2.25E-05
													TCAACTGCACCA	0.392966639	0.66218856	EMC	Both of them	Random arrangement	ADTCVAVMNNMHLCNPPQPELQMSDTHLYPMDEPMPNIFSMNDIHEPLYEQFELPDIDDIVEIVCNALEAGGLHSEMPWPDTWWP	2069.185349	1.246811868	0.327350309	3.808800033	0.000139643	0.001231441
AAAAAATCAATT	0.593978906	0.663077446	EMC	cnn	Is known to be	ASGGTIFETSPMDIEFPMPAAHPWEHLGLYSAFEFWDGALPNPLDLDSLALGDHEATLSHGEDVGFCHLMKDDDIMTDPPNTVND	796.0457205	2.307707517	0.631057023	3.656892216	0.000255292	0.002162779
													ACCCAGACTCAA	0.400971404	0.663077446	EMC	xgb	Random arrangement	ENEESNEAVTYYESLSDIGDCLHPGRRLDNHEVYDAFPPHDPNYCYGVPCYEPSIQDLFENEMTLDCLMQFWTINPCDGDNIGDS	1504.539218	1.208554818	0.379340175	3.185939423	0.001442848	0.010244635
AGAGTGTTGGAT	0.327048734	0.663077446	EMC	Both of them	Random arrangement	PPVQHQAPEDFFIFESQCDPQEVTEYFDFWFPCEVAETVPHIGPHLESMMSQSPYTEHIDDQGGQDNFDANWAECMLCMLDGFAL	4298.074635	1.103902027	0.388874774	2.838708245	0.004529655	0.028488542
													ATTCGCGCAGGC	0.472993096	0.665313771	EMC	Both of them	Is known to be	DMPIWCELDKFFDIDDCTPPVSQSAALNQMSQLSAPSPALESQGLAMTDMPLGCGELLDGEDFEAGHLDDFLDWVDLEMGAGNQF	1592.940386	1.759578798	0.366054311	4.806879048	1.53E-06	1.76E-05
TGCTCACCACTC	0.390773072	0.670693346	EMC	Both of them	Is known to be	QEWASQSMPDTPEAQTPFLMEDLQYYFSADEIAADTVLYPSPMKDLDGTSLEPLPPADDGLESLIRLFTAGESMHLDEVTVQMWG	2281.777425	1.152092177	0.34601166	3.329633968	0.000869602	0.006520043
													GGTACTTCAAAT	0.38525187	0.679806751	EMC	Both of them	Is known to be	DMPGSSEFLEMIIDLPEEPWVGNACGWHDMDGPHQSDELPDWVESYLIDHQELATTGGCINPLPPWNMTTLDSAMWDLFTDDDFW	1958.664779	2.150966458	0.458089051	4.69552034	2.66E-06	2.94E-05
ATTCCAAGGAAC	-0.399424211	0.683149493	EMC	Both of them	Is known to be	EPATEGPSVPCLGPPPLFMDGLSSLGPMHLPPGSSTSGAESGPEILWESLKSDVSFESLLFQGPSMGGIFDLMSSITWSTWGEGE	1162.311466	1.33317693	0.473434877	2.815966871	0.004863068	0.030278097
													GCAGTTTGGTTT	0.420274614	0.68838762	EMC	Both of them	Random arrangement	VGPWMYGMGEIINNMPLDALQVDELFEGFTCDFDCQFPAAHTMLSSVLQAPETTAREEPTSWEENWPYGQASDPDPYVQATGQDS	1589.610187	1.372470978	0.370639854	3.702977336	0.000213084	0.00182391
TCCAATCGGGTT	0.424769617	0.690450185	EMC	cnn	Is known to be	ETEPGPSFMTTIDTELEHTIPLGHSNGHTSAYGSTIAGLLDLPADNAIDELFMGMDLPGPEPPHHYHQWAELDGTDPPLMPWPHL	2110.173674	1.635115567	0.405491503	4.032428686	5.52E-05	0.000519441
													TCGCTCATAACG	0.32290081	0.69534836	EMC	cnn	Is known to be	PAGAPSRCVCYSDWEPIILCDDILGLDALNKPPTWEGGSDLLDPFDLDMFGHELAQHDFLGGQDYFTGYDGGSCSVNDPPDPAIV	3703.010277	0.990462896	0.375017062	2.641114219	0.008263386	0.048123783
CGCTGACGAAAT	0.382169923	0.695813157	EMC	cnn	Is known to be	PGMDMEPPPDIMPLTPMPPPFEHGDWCVPTDMTQCKTMALNRDSLDLPLTPCMTGELDGFFNDMEHGELECDQFLMDVDFYILGP	1242.121419	1.253377749	0.390198768	3.212151993	0.001317447	0.009462703
													TCGAAGTCTGTT	0.298853953	0.695813157	EMC	Both of them	Random arrangement	SHDDMQCEATPLEHLHTNIQFHYAFNQDFIEPNMTDITNYWEDGLYLADLGAHLFGEPEPAAEPCSDEGLGPAINNMYIFGLDEP	5578.816716	1.3713657	0.381809012	3.591758329	0.000328454	0.002726666
AATGCGTATACC	0.332468525	0.699705219	EMC	cnn	Is known to be	HDSQWCSTCAQRNDDPPTLPPPVPPWELSEEQSWCNENLTPPELWGLNDIEDAFVTYDLGGLGAMDIEEQTFLNPTWEHFLLGGQ	6662.949959	2.18921954	0.468408027	4.673744713	2.96E-06	3.25E-05
													TGGCACAGGCCT	0.493161638	0.701459453	EMC	Both of them	Is known to be	DKGGEVQESTPSGAPLLHDPGDFSTDVPLDDEWMFPMMQLVPDMTLPLDDYSDAEIMDLLSCCGVGWPIEADNWTPDGTEFGEPW	1166.760347	3.438410034	0.687895547	4.998447875	5.78E-07	6.99E-06
TAAATTATGTTT	0.498913449	0.703751751	EMC	xgb	Random arrangement	CIPQSIGSSVMDMLPPLSRLHDGGPVYDVGTADHMPDNVPGPEELGFTDWSWESMDNDQDGIWNVNHFPEPTTWSSPCWDLCYLD	1506.529841	1.855957924	0.453668926	4.09099636	4.30E-05	0.000413344
													GGACTAATCAAA	0.477057354	0.706227432	EMC	cnn	Is known to be	APLRADCSADGMPPSFGLDDWDRSENNTLVTDCSSDGIIFGGTTLEEIDLDELTFWPAIGSMADDEAFNSMLYEWWANMMDSDDT	2241.074938	2.45704561	0.456012372	5.388111734	7.12E-08	9.51E-07
CTGAAGTCAAGC	0.319725929	0.706393297	EMC	Both of them	Random arrangement	RDDALFQNENWLHEYPMDVILGDLDCPFEPPTQEECFWQLITHALWQCQEDEPAPPPEFFAWDLPMHDNELAWDPLSQDIEDHNM	2795.552072	1.412279139	0.436572755	3.234922755	0.001216756	0.008777649
													TCTCTTATCAAG	0.377059005	0.709476436	EMC	Both of them	Is known to be	QPIEDIMLGMWDEPFQGWDLPPIYPTCVEPPPSWTPAPWHGPIYDELDLESQALSAAQGPPMLHELVNTEDFYIEGGTAFDMGTG	1475.373882	1.575408526	0.513276238	3.069319035	0.002145473	0.014706731
GCCACCGAACCT	0.982067833	0.710431021	EMC	xgb	Random arrangement	YYNYWERGGASGLEDAMDHTLQGECMPCPDHDIPFDDPGPFWDLEWTACSDIEQIFWPEPMPLQEDDNLWPSLGNSHDCAQWGTD	265.6467088	2.355150172	0.635251505	3.707429503	0.000209374	0.001798364
													GGCGATCAGGCT	0.441657342	0.7135087	EMC	Both of them	Is known to be	GGTDDFELWALMEPILGSLFEDPYQFVPDTDMTMGLDLAALGIGDSLSPGETTHDEALGENLDMPPEISTQMFLWTVESPHNDFC	3330.088461	2.144794202	0.383780606	5.588594543	2.29E-08	3.28E-07
AGGCTTATTCTT	-0.401698122	0.716759526	EMC	cnn	Is known to be	DDFDHDFEMLNAEDMATDIEIVDNFFDTVDTTDFLYLGSPAWFDFLLDIYDPNVANRLPPCDFVTEEDTQPSAGGQGGPPDLGVF	1301.97118	3.077457765	0.62429833	4.929466597	8.25E-07	9.75E-06
													ATCGATGAATCG	0.429537848	0.716759526	EMC	xgb	Is known to be	GGTDDIPDAIPLTHIFSNLCFGVDDFDYSPPCPDNADIAEDVYNFEDLMSVIIADGWDDEDQQGEDSSPGFLGLGSTPYVDHFGG	2119.766299	1.367832625	0.432979696	3.159114935	0.001582491	0.011124573
TGAGCTTACATC	0.530594857	0.716759526	EMC	cnn	Is known to be	GTYADPSAEPSAPIRNNSPGISDANDHDLWEPSHECNPMGLPDQESIIMNCLFDYDQGGEDDIDSLPFEWFPPSVWATTDWWYVE	1587.374789	2.147039661	0.520299136	4.126548578	3.68E-05	0.000356453
													GCACAAATGAAC	0.477986842	0.717327037	EMC	Both of them	Random arrangement	VHYPAPDEFESAMIDLDPLDAVLTWNPYGCETHSIEEIHPPGDEFDEFMEALGWSNHQWLPYNLLQEPVQPNDLDILGHPQDHVC	1331.925667	1.923255144	0.499778189	3.848217439	0.00011898	0.001062463
GACGGAGGCCAT	0.839020997	0.720592542	EMC	xgb	Is known to be	GMLPYHDGELWWDLPLPEPQEPTPWDNAEWMEYMDIFPNLTQELEWPSDHFDWCMHGLSALDMFGLQLPESQWFSELCGDGSPNP	269.6119337	4.25243518	1.399102946	3.039401205	0.002370489	0.016027483
													AGGCGTCATCGT	0.29309153	0.723621932	MH	xgb	Random arrangement	AMDAPDMSPVPQEWRPSHSTAASVNIDMIAPVDYNEQTTMSDRPWCDTLEDTFTFGLMDHWFTVGQVEPNLADWTQWTHWPDQLF	3546.284564	2.401063318	0.453368534	5.296051972	1.18E-07	1.54E-06
GATGTGTACGTC	0.544840216	0.734702518	EMC	cnn	Is known to be	RIYEHGHFSADYNTGTGISTDEHAFWCPDDSTFPLPEPTFDLTLLGADPTFSGLLGNSWPIQNASQDEVEWMEFLLNGMFDLDEG	1347.691454	1.355186949	0.484866584	2.79496875	0.005190473	0.031995007
													CGTTGTATGGCA	0.469411855	0.743626264	EMC	xgb	Random arrangement	CECPYENHETYLYESLWEASAIEATIPTREPTPDMAPPYDVLWGMMESQISLNLSGMCPIIDDAMFNIPHDEPVQFSLFGPQDPQ	1359.462221	1.339604251	0.432639954	3.096348909	0.001959197	0.013580111
GGATGGTGCCTT	0.292993262	0.744883016	EMC	xgb	Random arrangement	GPSTGLDYLLMITPSEVNPQICPDFFSPEIEGESSSNLPSMHMFNIASSMDESWAEFWINNLGEYPDDPCRQADDAYDENGAANE	4944.40711	2.164954711	0.397886797	5.441132316	5.29E-08	7.23E-07
													TGGAACAATGCG	0.291541347	0.744883016	EMC	xgb	Is known to be	WALDEGPLDHLGMYAMDAPHSWDLGTDALDDHVLDASNPPSWDDFVADIIGGSEGKCAPSSTPDSQNFLDWLIDYDSIFPRLGGH	6018.64377	2.620166927	0.277630674	9.437598825	3.81E-21	1.73E-19
CAAGCCTGCCTT	0.378488021	0.746016492	EMC	xgb	Random arrangement	IPADDSTSKESYPDPYGQNNDDGDLLFGLLEPIDTCIFCEDNMLGLPPQMPVDPDLMGLIGASGNVPHDQYCDFGPIGPYFWECW	1948.073842	1.455405426	0.536690073	2.711817304	0.006691546	0.040197943
													GGCATCTAAGTG	0.293092701	0.746054153	EMC	xgb	Is known to be	AGGGGPTLSPASIWELLSFDEPGDFPKDHPMTELPAGALLDTDNESIIAEDLMDEGLLSPDMPVEFDMNFFPTEWLTCLQALDFP	4227.896641	1.584713323	0.358375659	4.421933472	9.78E-06	0.000100582
ACATCTCCCCTG	0.320032803	0.747255123	EMC	cnn	Is known to be	TITDTVDDTPPTDNCWSEFMPCNYPCWDATRQNNSTNAVFWHEPLASDLASEDPFYLGPNDHPGMAQLQNEHEWEMGLWDYGNIY	4130.49265	2.259117298	0.366028244	6.171975353	6.74E-10	1.12E-08
													CACACAGTCGTT	0.263208578	0.748482182	MH	xgb	Random arrangement	EPDWNVCFVNDEPASESDLFRELMQAPWALSDLWHGMYTIQPSDDCVLFTTTEQPAGNPMEGVPSLYTTDPMQSFTDCQPVENPM	4259.538527	0.60192387	0.227750374	2.642910568	0.008219674	0.047925536
GAACTGGAGTGA	0.406367167	0.749437003	EMC	Both of them	Is known to be	KDNGLSAMGPLQCAPDIPPTLPNLELDIWEHWGEGVTGGLTLPDMGFPDPAIGPTGLEGTLPDFDDCIQMWSYLYECAEWMETMY	1172.726569	1.98503626	0.345425469	5.746641276	9.10E-09	1.34E-07
													ACTCTATGGGCA	0.348008148	0.751106683	EMC	xgb	Random arrangement	DGLDNHHWWNCLMNNPCTEHPTEFGDAHRPQYPYEPNIMVGSLDPVLDWDLEYQPGGQDLDNWMEEMYNDNSIARTEEGCMDATM	2310.173976	2.041835736	0.465993253	4.381685195	1.18E-05	0.000120837
GCCGGCGACCAT	0.382954682	0.751106683	MH	xgb	Random arrangement	AQVPYDFAWMADMYNTHPPGQLLQISFDTQESADHDSQPSTSHTSCEQFANMFFDLDWTAIPLPQCDVFTDTQMHEYTPQHNIDE	1738.458417	1.637351059	0.476649629	3.435125007	0.000592281	0.004615318
													CGGCACATACGA	0.555538539	0.756608792	EMC	cnn	Is known to be	GEAMAWLCTILNDLVGPLEDFSEPFMLDDLGSPSANPDTAFSGWAMLNDSVAIAGGETGDVWAEYWSLPEDDGGPSQSESSKGCK	380.6398133	2.264178702	0.85642623	2.643752169	0.008199267	0.047862856
CGGTGACATCCG	0.468075532	0.756608792	MH	xgb	Random arrangement	LSPLDGCIPLYNDPRQCGPLFQPWNVWTDTTTVPRPIFEYDEQEEHEVWSLINPLAGDLNTCADNPFLNHDNFMSDFEETMRDLN	699.3632954	1.052309112	0.369268808	2.849710262	0.004375907	0.027661984
													TCCCTATTCCAG	0.469136113	0.756608792	EMC	cnn	Random arrangement	QWTDPPAQVEYAMQEIDLEACRFHPADMGHQFPNPYNAQFDSVLFRSEFANLPDWDLMGDNEPQPCNEYQYWVTHSDFHELQEEI	826.8578134	1.473720421	0.44697108	3.297127008	0.000976793	0.007239752
TTGTTCGAGGGC	0.280486478	0.758360493	EMC	xgb	Is known to be	DGEPDTTPTAYPESITCDQDWLQGLNWMEGGVDSGQPPTLSQSPPLDHDDWLFAALDVPLSVYAGFFGHIEPGEGFFYGTYGGED	3481.935662	1.456111122	0.38163819	3.815422983	0.00013595	0.001201012
													CAGTCCTCATAC	0.277317312	0.760284096	EMC	xgb	Random arrangement	CPGCYHPMPDWINKAMEVPTTPHTQHRDIQDGFTAVASEWPEVSNDYMSQFLEPLMCQDDYSQEDEFMTEFLHFNEWHQEATDST	3944.201669	1.70994172	0.34400042	4.970754745	6.67E-07	8.02E-06
GCATTGGAATTA	-0.412769667	0.760284096	EMC	cnn	Is known to be	YNDDEGVLPPFTESVIDDIMGGQMGCLYMLTTPTPLYSPSPAPNDAPAEAGRCADTSLFLTQLQGDYWQEWMYPDEGPSGYALQP	1212.980595	1.417653235	0.503587882	2.815105934	0.004876116	0.030283245
													TTCATACGTCTC	0.357117352	0.779000728	EMC	cnn	Is known to be	AMCGTSMGIIPLMPTELAFMSEIEPWMQPVGLPGWEESPSPACSLPESPLVQPSPLLEFITQPIPGWESRQNPWDEFMDETGVDQ	1771.642796	1.605960654	0.493505435	3.254190413	0.00113716	0.008287892
AGGAGTGTGTAT	0.270144854	0.789129024	EMC	cnn	Is known to be	HFLNMSITGVPLPDPMSEYLPAFEPSRDHVWDLEGCTLDFLSDVTQDLKDLPDIGELMCGWFQDMPPMYFFGESTPEAWSPPHSG	2638.026755	1.15430312	0.387087881	2.982018238	0.002863549	0.018947598
													TCTGGGGAATGC	0.305854978	0.791847901	EMC	cnn	Is known to be	NPAVRQRTHVIDWGANDFMHSAPSPCYDSDYFDCDDLSSPSLCDGHLPGDFPGLDDILENVLCQPIGEAPFEWDFMGVERPPFGW	2982.768087	1.359106292	0.387634451	3.506154547	0.000454631	0.003599284
ATGTCGGTTGTT	0.278168361	0.794288028	EMC	xgb	Random arrangement	IDASPADFPIFVNDASPEPVDNCDPSQMEEWLWPIRQPCPERGEYMCFDVEDILHLPSDHDRMDIENLYYQFQDEHFDIMTYENL	2970.502412	1.209079988	0.390636034	3.095157342	0.001967085	0.013596756
													AAAAGTTGACTC	0.466603514	0.797699108	EMC	xgb	Is known to be	KAQEHPPFDIPLDEFFTLYESWDPQSYDEAQICLAIHNPPWHEPTLSDSPQLDNDILSWSDDRGGVLDFGMPLDELGCGKPGDFM	2523.591469	1.791839524	0.571180002	3.137083787	0.001706374	0.011910968
CCTGACGCTTAC	0.568565986	0.797699108	EMC	xgb	Is known to be	ASPTLTMDCDFWDIPTHPTISGFQNFPYPFLGDEEFEIPPIPLDSDESLQVSQLYLCDDGGTIQPPAQHLEDFLSTLEEHQDMFG	2046.603158	2.34315663	0.490118207	4.780798995	1.75E-06	2.00E-05
													GGCAAGGACATT	-0.324384292	0.797699108	MH	xgb	Random arrangement	LILELYEDAMATQDQFIPGEASIGSPQEVADIAETDTVGIFDSDWLQPCGPMNGLNYFLGVLSSFETQYQNSNVPEENWWWSPMQ	1476.206368	1.094247007	0.400426522	2.732703623	0.006281683	0.037919635
TCATGCCTTCAC	0.692595009	0.797699108	EMC	Both of them	Is known to be	SIMSELSSFIWEDNWQGLPDLEGVFDCEANAFEPLVWGTLDMPEDVGMPLDDDFLTMDRMALLPDTRPGHGPGESGGGKDGGKNT	477.7717219	2.967843883	0.776969822	3.819767253	0.000133578	0.001182162
													TGCGAAAGCTAC	0.28296715	0.798840129	EMC	Both of them	Random arrangement	FVPTIMEMPSLGPSPSDQEWTHFEYQNMECIDTEPASWPGAGPSMSDEVPEFLLPPYHCDFFEWLEPAMRNWGFPVQMPSEHETE	2116.96181	1.934190615	0.4161217	4.648136868	3.35E-06	3.65E-05
AAGCCGTTGTCA	0.3521562	0.804423266	EMC	xgb	Is known to be	AMSTPDPTETPHEMPFDWIEETVVCLGKSSTDSESLDDFDLTPLGDMDHAGQLDDFACSLCSMDIAGWGGGSPVSFPTFNSLDSK	2363.496662	1.4745547	0.407220696	3.621021019	0.000293443	0.002460748
													AGAGTTTGACGT	0.306329656	0.804423266	EMC	xgb	Is known to be	PDTECYTNSLDDLVPQPSTLEEYESLTPYIFIPENDEKNTDASGWEEPWQTPPGVELHIQGQGLEPTDDAIFGILDEPQFWDGPG	2052.268246	1.344815522	0.360459848	3.730833072	0.000190848	0.001647807
CTCATTGCCCAT	-0.303599746	0.804423266	EMC	cnn	Is known to be	LEDTPLPAYDLEQCMSIMDLWANEGGESCWTEPWNTGPLLSGNLLNEEPPPTLLVPYNTGHFHEEIMSRSCVEYVGPMEEGPSWM	1600.080888	1.190273108	0.417277662	2.852472623	0.004338055	0.027492839
													GCGGCACGCGCC	0.480448459	0.804423266	EMC	Both of them	Random arrangement	DSPMPEMDVPTGMGNMPAPLLEEGPTHPMDTQLPGLFPHNPQGWSMTEDWFQGFIDKIGWESSCDSHADFWDEAHSLEMWMELFE	349.7891471	2.193716932	0.655307287	3.347615655	0.0008151	0.006139261
CTACTCCTTTAA	0.243318181	0.806902035	EMC	Both of them	Is known to be	HDDLPPYNHFEPALLGNPLFQGPSLADERTDWNNTGIPFWDCLFEQLETLGLLPYGPQPYSPELPYLSVQPEGHDQGGSLDAQLN	3314.624574	1.164333906	0.225819728	5.156032712	2.52E-07	3.15E-06
													GTTCGTCGCTCT	1.07364918	0.809467951	EMC	xgb	Is known to be	EVEGNTMPETPDQSPSGHITAGNVEDIPWPQEASDAVWDTPSDQVDDLGENMSTPEWAVDLIFPDLEVCPGEWWPASYTHQLWFG	450.5879696	12.6509297	3.413794776	3.705826075	0.000210703	0.001806649
GTTGAGTAAAAC	0.530644704	0.810691686	EMC	cnn	Is known to be	ALDFENALLMAAWAPGPNELGLDCSELPEPGCLPCDFIWGTEGDYQAMCSTRDAAYMGEEFFPWINQQLSMEDTMLPEDGGQGGA	416.9812547	1.662667201	0.604089676	2.752351626	0.005916895	0.035980531
													TGGGCTCAGCTC	-0.457075981	0.813828664	EMC	Both of them	Random arrangement	GMEPLPLPMSMVDLSDAFHLPPLPMTDMPDQWDDLPPALHTDHQLSNVDATMPPTLDHILQNMPGEYYWEDIAYAAGENEFDLMN	575.2856845	2.13673838	0.621721055	3.436811995	0.000588604	0.004593892
TTGGGTCGCAGT	0.268161259	0.816769684	EMC	Both of them	Random arrangement	PEFLADFHIDSWTNEESHNWIEDWISDPFDRDWPIDPFVTSHLPTGGNSVQAANEANDNMAMLPLFLQDEDITTFEPELLMIYQI	1328.45573	1.461240929	0.526302494	2.776427899	0.005495982	0.033710506
													ACGAAGATTCTT	0.246885121	0.820087193	EMC	cnn	Is known to be	PEQTQDTMSGCVSDHDIDEAIEGAGGAAPELSFLMGHHWGVPAEEWHPFSTNDPAPQHWAFNIMEAPMDMNYLDLYNLLDEWWFG	4305.265355	2.100827455	0.379818748	5.531131542	3.18E-08	4.48E-07
GAGTTTATGTGT	0.251857684	0.820087193	MH	xgb	Random arrangement	EGMEPTPKRTIAEHCNSMLHCEQTTYQEADPTNETFHTDVMTSWDIPNNGFNPVESWISWDTDATWALPEAFLREEWELCLFGGS	4844.629822	0.991903942	0.220000373	4.508646638	6.52E-06	6.88E-05
													GTGTAAAGCATT	0.237612869	0.824613008	EMC	Both of them	Is known to be	VEDLLDDMWSSYLNMNPDILMGLEPPCVPPDPSADMESMTCALNADGGSLNDFMEILDTFCMDDTWVEAFTPAWGNCEFMAALGS	2390.299161	1.590341769	0.329914118	4.820472	1.43E-06	1.65E-05
GAGAGCAACATG	0.21654955	0.825006034	EMC	cnn	Is known to be	DNNNDMPDPYAGHPRCPSPILGDLAPCNDDGCTHTQYPGPAGFNPLAPPPEDVLSSDMLNLFDDIPWCDYHFNMMIDHMLFFPPN	4419.546288	1.379341398	0.236056805	5.843260486	5.12E-09	7.73E-08
													GCACTGCATTTT	-0.323164882	0.830793809	EMC	cnn	Is known to be	DDFFMIDDSSLGNVLNLFADFECDAFYDDILPPPSMYHPGTDTNLFDKLFNLCEDPNWEAVFEVFEEGGGNAGEWTGDNIGAPVQ	1283.65156	1.255875981	0.445831759	2.816928034	0.004848539	0.030225608
TTCGAATGAGAA	-0.386613578	0.835367503	EMC	xgb	Is known to be	TPDDDGDDPLFSNPFRMQDWPPDISVSTSIDQDLVDSLMCFQDMALPDLGDLESHELWTPESQEPPAPNEDFLRLGGELVLPALG	1176.303244	1.559166463	0.572915299	2.721460685	0.006499412	0.039091121
													ATTGTGTCTACC	0.238861542	0.850500738	EMC	cnn	Is known to be	FDGLPFANEHTWPPAQQWEDLQSDDWNVPNEFYVSPIFPDMLGPSVQHCHDPSDPPGYPGMAEFPEESFAHFLLNDLDTVLEVLT	3586.511692	0.987959465	0.273550999	3.611609782	0.000304302	0.002543207
GCCACTTATACA	0.225989726	0.86213156	EMC	Both of them	Is known to be	PNYIELEEFFERMIDPMLPEWIYDGQIPQAMDIPDPMMGAQPTYDGHGFMDLDPCMVFQPWDGFQDVLDKLFCDNPEGETGVQSG	2464.252545	2.331213568	0.380700885	6.12347819	9.16E-10	1.50E-08
													ATAACCAAAAAT	0.281409276	0.870188081	EMC	Both of them	Is known to be	AEYEMPPHGVVEMLTDDIFEELSKYDSFDKEPLPEFMLPSMLSLKDLMDFDLDKDLPDSNNDEIWTAANDAILLPEVQPSGQQAT	964.9009075	3.09685215	1.081058228	2.864648794	0.00417472	0.026615342
AGCGCCGACCCT	0.237757347	0.870818574	EMC	Both of them	Random arrangement	PCEGVWQSDGDTKDLSNSDVCWLTPEAWDVTFTMQESLPWHFLQEIGMDNPWVDIPMDDWAAIFPPMDQEFPDLSAPWPDQSPSD	1902.306833	1.394454994	0.464140862	3.004378862	0.002661237	0.017775055
													TCTCGGCCCGGA	0.253649991	0.8716837	EMC	Both of them	Random arrangement	QEITTDWINQWPQLNQIPFDDEMESHEFPPNDDMLCHLHGPAIPVGWPLQDSVFGSPNAQSNTPTMEEWWECWLNMLIDPEVHCN	2740.564962	1.906317589	0.388861693	4.902302348	9.47E-07	1.11E-05
CATTCAAAGTGC	0.213290397	0.875250618	EMC	Both of them	Is known to be	SEAMDVPDSVAHFDAAFPEVLQPLEDEEPDPFSTALDMFGCFSTLYDDQPKSLDDILAYQLLDMMDTEFYGLNGLGGAEIGAGGR	2144.385497	1.390015097	0.38599877	3.601086853	0.00031689	0.002639505
													GAGACCATGTTA	0.185989083	0.875250618	EMC	Both of them	Is known to be	PEGGSSDVDYDGEAQGSHGSNVSPQGYPWSWEFAPETPNTLLPEAIFDDTPPATPMIHTSQEFSSFISWLFDNLQDGSGQAYMDP	3073.691514	1.715947318	0.335593209	5.113176524	3.17E-07	3.89E-06
CCACTGCCGAAC	0.24475197	0.876739868	EMC	Both of them	Is known to be	ASMEADPEQPLGGYEEDNAEFAPEPTHDTLSPAQYDGSKPCIMTADQPGSTSPLPFADDELEAILWYQPVEDELAVLLNWSDNGF	1518.148045	2.048249201	0.646974852	3.165886889	0.001546109	0.010899739
													CCGGGGGGAGCT	0.282051781	0.876739868	EMC	Both of them	Is known to be	RQADMLDSFTASLAPDAMYVEPIDEEDASELLDFFSDDMYMLPMFEVELLDPGSEDLGQLFPQEWPGGYWGGGGGETDGRAPQFL	766.8660383	1.62851445	0.558813577	2.914235653	0.003565606	0.023251507
CGCTGATGTGGA	0.402744832	0.876739868	EMC	Both of them	Is known to be	QDLPDPTQLPMDDMNPVIPLLHGLDLGTQDEFLDHGDLDDLWKTLDCSLPVLDRVDHFFELEGQGQGGDMGGWGPQGGGREGGTG	666.4569665	6.793219132	2.270598874	2.991818243	0.002773213	0.018398989
													AATAATCGCTAT	0.258738163	0.878989767	EMC	xgb	Is known to be	AGGSEGADALASYGTLLSQLDPGDPPKLALWLDGLEIHDFDFELLSVDEPAQDDGCATTPMPQLWDSLFEPSNFVPCGTMEMDPS	980.4978716	1.839444343	0.661382806	2.781209802	0.005415673	0.033259074
GAGGTTATATGA	0.215755014	0.880008708	EMC	cnn	Is known to be	HGFTTQQMGDGSTTYTHNFHEDIAGFWDDFLPSEPFEIPPLLGVLSPEEQEPPWLGVDLFNIWSDECFLTPDVCADGSWGGFPGY	2057.484646	2.043688746	0.373348516	5.473943674	4.40E-08	6.09E-07
													CGAATTGGAGCT	-0.190811858	0.880168696	EMC	Both of them	Random arrangement	EPSHPQYLDEEAIDPLQDLGQDYPGPSCPLLYPGACPPMPPQPCINIEFNLPDINHEFSSAICEYFLDWMDNQYGWPGPDEHTPQ	2254.965605	1.686893388	0.31569823	5.343372974	9.12E-08	1.21E-06
CGGAAAATACTG	0.226030874	0.880326882	EMC	xgb	Is known to be	AEYEVDDMGVQLVPTGDNLLQSILQYWDQDDLTEQCADPDLGPTWDLNWLEFEWLIPDQILDPVNDVMAPSEPKQWPLSMPPDGI	1464.812189	0.968039541	0.364141845	2.658413351	0.007850954	0.046320626
													CGTCGGTCCTGG	0.18192314	0.880326882	EMC	xgb	Random arrangement	GPWWHFYPNNDEEPWWPCCQECFLGQQNARADDPPPESVEHLIGHPFPLVDQLPPEDMPDMPIPEMGNIAYEDDIFADCAWYDPD	4076.251388	0.86849101	0.289365021	3.001368329	0.002687692	0.017927596
GCCTATATACCA	0.262357651	0.880326882	EMC	cnn	Is known to be	TDDPGTDLNLGNLGDAQPGVGHELNEEHFVTYFECWTPVFSMGDQLEESLKADSAFESLWHPEEDHCYPPMMPDIEEIISPEAYL	1994.8818	2.037781199	0.503122525	4.050268271	5.12E-05	0.000485716
													CCTGGGCACGAA	0.228988882	0.880374598	EMC	Both of them	Is known to be	DPAMTDSMDAMMAGFPDDRPLIDFDSIMDEAKFDSLFSFAALETIFQSEVQLGDWLMLGGGQESMAHPPSFNPFDWDWGSDTDPV	916.3510406	1.492980185	0.454495232	3.284919355	0.001020116	0.007545811
ACAGCTACGCTA	0.169243042	0.881481343	EMC	xgb	Is known to be	SDAVDLDTQEAEIQYLLSPFLPPRVPEASWTAPDFPRINTSEDFIDTSELDPGSASTTMNDLYMLWEQPMPLYWEYLFNELEDPM	5603.677521	0.968314532	0.340745235	2.841755167	0.004486593	0.028289511
													ACTGCTCGCGTG	0.192761485	0.881481343	EMC	cnn	Is known to be	DVLHSMIELPPTLNWTPFPLAGVPVVEPMALDQLYSALDNLDGLGMELPDAMIPELESNSEAQEGYDPVDTGFEEGWEGFMYQWP	2085.635296	1.493627199	0.434113303	3.440639091	0.000580342	0.004536554
GCATCTGTCTCA	0.245574288	0.881481343	EMC	xgb	Random arrangement	PCWVCYQDPVWCPNAYESPSNHEDDGAELGIHEFMEPFTLMHSEPTEMEHNFYVLPEFDEPWEIASPEFNWMCEDIPGIADDVEH	1321.408705	2.678378149	0.619345257	4.324531621	1.53E-05	0.000154288
													TTGCTGACCCGG	0.239698481	0.882068216	EMC	xgb	Is known to be	PSTQPQLSVMTASHGSLADLYDLMVDYPVDSPTCKASMDHRKDAKPNTTEEATLDAAAYASLDMFDFELDGMFEQGSMWIMEDYA	1521.108993	1.798820545	0.508984884	3.53413353	0.000409114	0.003291511
GAGGTCTATCTG	0.168247496	0.884891413	EMC	xgb	Random arrangement	PVRDEDEPPGNCFAESMYVPQGFEFVSEEMWGSLISGLCREWDAPVAEHSPETTDNAFPGDAEFDLNNPNSLMYSILYDCDTNDP	4034.866062	1.961639794	0.308125903	6.36635795	1.94E-10	3.41E-09
													ACATCGGAAGTC	-0.21237113	0.884971877	EMC	xgb	Random arrangement	IAGLMEHAEAPSQHRAVEQYDQSQDSLVGFDVDHQSAATCNMYLDYWMATLRGSPMQLDDIYPLFPGWEDWNPESFCIDFATLDP	2612.754489	1.663863862	0.451887808	3.682028666	0.000231385	0.001973745
TAAGATAAGCTC	0.193305857	0.891106104	EMC	xgb	Is known to be	GWSNDESGFTGMDLIGKLLEESLTCDVQVESLIFPELAAMALGSLDENELAMEPLGPEGLNPLLATYTMEASPAGSESFYMETMP	1288.097078	1.811585908	0.501081781	3.61534978	0.000299942	0.002511004
													TGCTATCGGATT	0.211112472	0.895963871	EMC	cnn	Is known to be	PTSTTLDSTNIGGIITLPEAPGHYNPEPPMVDIYSTALSDLWNCLWSDLYSDMDTQPDLNLSYTPADTWNPPLDGGNQGGAGDDD	3682.745789	2.733220886	0.478130758	5.716471574	1.09E-08	1.60E-07
GATAATTTAAAC	0.197665737	0.898964957	EMC	Both of them	Random arrangement	KAAYQDNGPSPCTDFVNDWCISPELLADIHDFGWQWDHLPKFDPMTTDDLLNFNDPISTEHFKHPHMPSLEDPLPEETQAAPGSP	1489.878648	1.602015583	0.407196581	3.934255978	8.35E-05	0.00076593
													AAAGGGGTCCAG	0.209157379	0.899665116	EMC	xgb	Is known to be	ICEETPSMISPLSEAWDDFLGGGSMSLPGGGFGGGHNEWCLLDHLSDQGILLYDLGPCGSGDNTPLDNDGTDIIQLLSSIMGQEP	2618.867632	2.224899685	0.372824495	5.96768645	2.41E-09	3.75E-08
ACTTTATACCTG	0.157685909	0.899665116	EMC	cnn	Is known to be	PGENNTLDACDNDINLAPTGACEFSPPLPCWGLPYTLSNEQHEDIICWEEGLGNYGNELEEELDLLGNAWQGMLMEQPAEPGISG	3647.202129	1.497994929	0.379603818	3.946206175	7.94E-05	0.000734147
													ATTCGCGTCTAC	0.193873722	0.899665116	EMC	Both of them	Is known to be	DACCDSWLMFDCGDMSPGCPPEHAAIMADTPLQMQSATDLELGLGLSTEDWMGSLNLDLLNMLLDSDGGEFTYFPDFLGGLGWAG	3637.292386	1.783041403	0.456478041	3.906083625	9.38E-05	0.000854583
GAGATTTCTTCC	0.19188809	0.899665116	EMC	Both of them	Is known to be	ALTGEPMIDDMCGMITADELYYTPNPAPPVNLLDTMLSGGLEDDVESLILNLFFDSAMHDAWTDSMLGPLESGLAGAPSQSHEEQ	3626.349013	2.236305516	0.313030079	7.144059529	9.06E-13	1.97E-11
													TATCCCTTATTG	0.193362075	0.899665116	EMC	cnn	Is known to be	HHMGSSTETLVRPIASSPAGTEYVHDEPEPVYMTPYGPPDSWTPMDSQNFFDHGMQELLYEDLQAMVESWWKPPIMDIFGDEGGW	3087.714239	1.006069299	0.289251841	3.478177688	0.000504835	0.00397137
ACTGGTGTCCGT	-0.199628979	0.904112763	EMC	xgb	Is known to be	SDTDWTADNLECFPSLDLDSDQMAELLSLGHAGNNQQLCWFELDMLVSDSPDPGGAFPGDSDGSNDSPLDMLGYAGPLGNTLHLE	1775.984741	1.756068547	0.38284156	4.586932903	4.50E-06	4.83E-05
													CTATTCGTACTT	-0.154486757	0.904112763	MH	xgb	Random arrangement	EPDHENGNCFKAWEAAHKWMYPFTGAWDGNYFWCQALPAQMEDLIMPNDPNVEDHGEVASEESYPSFDITQDCWDLFDNPLMTDD	2409.233382	1.319829815	0.335255716	3.936785421	8.26E-05	0.000760722
GGACGTCAACCC	0.170999331	0.906699741	MH	xgb	Random arrangement	PGLSESSPSAWKGVPGYFTDGIGDPFRGPSMEQHANPHTQPGPTEGGDTPYDPPAGDHDFWMLLSGIDGPEIWPNVLSQIIEHDQ	2327.179157	2.075370304	0.417240233	4.974041665	6.56E-07	7.91E-06
													TATTACTCGATG	0.247769604	0.906699741	EMC	Both of them	Random arrangement	EFAWQLLQPVGVEPSWCTLSQLDLPDVDAHLEQATSNLFSQPYMHDFDPTQDDFSTINELPADAASQSDDPEPAWMMFDLDTTWP	1297.73368	1.590926177	0.488165975	3.258986204	0.001118111	0.008173095
AGTCTTTGAAGC	0.129464185	0.912372094	EMC	cnn	Is known to be	LCGSPALQINDSFSTSGMFQEATWLDNDLAMCPYTPGPHLQDLLGESSDLPDCEVDLLISNELHEECLWEGLMPDNSMIMPGIGL	5852.614787	1.185466501	0.367393169	3.226697177	0.001252279	0.009020778
													GGGGCCCTTGCG	0.126166386	0.920873484	EMC	Both of them	Random arrangement	TAANVAQPDHTPHDTAECSPRFALTPAFDANFDMFDWINMNDSQFDSAIPEAFDYLTTLLDYIPMINMEVAPPDMEHIPFTWDAM	5227.127487	1.35536555	0.430990473	3.144769163	0.001662179	0.011651712
ACGGCGAGATCG	-0.178170909	0.921341215	EMC	Both of them	Random arrangement	CPDEMVPMAEDFFQPPDWLHELDYDWVCEPMEEFNEHLWMDWHIIPDDLLAPFSALPDSFMQGASGCSDDIQDESTQEDPSDEDP	1968.321565	1.140075476	0.335821793	3.394882348	0.000686581	0.005283688
													ACGCCAGTGGAG	0.133248574	0.924095142	EMC	Both of them	Is known to be	WETMPGPGAAYEEMIVPKWCVTPWDDDDIQELLCDDDPFGMPSLDDLYDLEVTFPEDIPHGKYVTDVFSDDEFHQHLAFPDPMVL	2184.237951	1.193030613	0.31051324	3.842124774	0.000121974	0.001087234
TGAATCCCGAGC	0.187535862	0.92633444	EMC	xgb	Is known to be	GSSGGHLDICPELWEWHNTLGEAAPCFYPDEDDPVNGIPPQLDLDYDLWLKFEHLFEGMAPQDSVSHPDISFSWDSCPEGLPPIF	1316.32894	1.185531784	0.443796889	2.671338653	0.007554938	0.044894813
													GTTGCGTAAACT	0.12383078	0.930310828	EMC	Both of them	Is known to be	DPGGQAVQTADTFDPYLIDYMHGCDTPWQADEFTGREWDPMDMLIFLDDLQLDLGLLYDLDDTAMAAFMNQEAGEWLGTGGAGDP	2030.50667	1.914597985	0.569145248	3.363988353	0.000768248	0.005821768
CCCGGGACCGCG	0.162236798	0.93095438	EMC	xgb	Is known to be	SSDTCLQFWEGLLSMNDFTQPLPFPSYDMLLPPAEEMSLPMTDTCLTPEVVPGVPEMDHKDALAMLHCVNLDDFLFGLAPPPGSK	849.3105549	1.737298066	0.608658667	2.854305968	0.004313097	0.027404755
													TGCCGGAATTCG	-0.168157585	0.931048159	EMC	Both of them	Random arrangement	IVHGVGEDLMDFLEDPFVDELCDNDWPPQPWSWAISDAHYMTMPRDVACPWMEEENLDMCADYIYMMDSPHNYDLEFPLPDENQQ	1262.968659	2.278066698	0.643063353	3.542522969	0.000396319	0.003209406
AGACACTCGTTT	0.10463046	0.933969604	EMC	cnn	Is known to be	EDLGVQGTDMILPNIWTVAPNHPQPARDSDLPPTTLESYAGDSHSLSQGLQGSNYILDDLLKELAQQFDEYMGFDLLPCNAWDLP	2765.572127	0.931587365	0.304680464	3.057588115	0.00223126	0.015231579
													CCATGAAGTTGT	0.108991255	0.936763481	EMC	cnn	Random arrangement	TGYPPVAGPNFSAYLGFDLGCCPHHPVNFEDVHTADAESSEIILGDSLLDHPMFEPVDWNSACYEDFFDICLQNEDLDTMIMTEQ	2816.031797	1.493584683	0.375893675	3.973423293	7.08E-05	0.000658757
TTCAGACACGCG	0.1110848	0.938739085	MH	xgb	Random arrangement	DDGNSLFWCNVRTDLGPCVANDEIIPCEAATCVYNPEFSFDLDQAAEQIWRSEQLDLSPPTQTEPNDMNWEDMGMDFEHVEKCFC	2830.081118	1.376925805	0.35661558	3.861092677	0.000112881	0.001015315
													CTACCGCTCTCA	-0.134816961	0.939406874	EMC	cnn	Is known to be	SASGSMLEGLGGTCQPYDYTVVPEYTLDADDAFFPPGPALESSLMEMNWPPDTWLWDMHGDFFDIGLNDDQLQGVLQDWIAFFHE	1927.094844	1.852085995	0.610069163	3.035862339	0.002398488	0.016194698
CATTCGTAAGTA	-0.125270928	0.941656341	MH	xgb	Random arrangement	TNPMYQELWDFEWFHVHNSDNITPEPHGVNDQPTISTGIFTPIEELAFEWLDHEPMAQDPCACPCDFTQPDHDQSLVPMWTALND	1348.898577	2.844780261	0.422888114	6.727028181	1.73E-11	3.37E-10
													CCGTGTTTGGCT	-0.093490099	0.941990281	EMC	cnn	Random arrangement	PGGFRQILFENDHDECDPIVHEVSPVSHWEVYNPYPWPPLESYSDWAMQQYDVGGQPSNNPESNFDQIWAHLEEEYFSGMFTMQM	6297.667268	1.075198066	0.318149126	3.379541157	0.000726069	0.005553086
AACGCGTCCACA	0.127613256	0.943885889	MH	xgb	Random arrangement	LDSTEPKDTGAPHPGTAGCEFHPLELLNENNPEEDQPLIETWLAGSPLRLEPPQWDAGAWEFKEWVPADADMDTMGMDQIYTMNC	1184.045615	1.823189255	0.645844723	2.822952931	0.004758356	0.029813414
													ACCACGGGATTC	0.127307473	0.943885889	EMC	cnn	Is known to be	AVAPLSDHTNLCAAMSPINIPFGYALGTLDEFVSPPTSVSHMGAIDDVFQSLFELLDGAGTESWDVFSPISPTDDGLWMFSTVGE	1136.245286	1.532950758	0.499737587	3.067511426	0.002158492	0.014775534
GAGACAGAGACG	-0.120736088	0.943885889	EMC	xgb	Random arrangement	NDPTITGPEPPNQEHGHGDMTNGGCEDADTCYKDPLQEDSMVPPIYTWSAEQAELHWEDFDGPFGIWGMNWDTILVDEIWGDDFR	1294.950658	1.396008033	0.429138975	3.253044152	0.001141758	0.00830512
													GGAACATTAATC	0.165670927	0.943885889	EMC	xgb	Is known to be	GFPAVLAPPTDLGNLDELTLLNTLASIGYSGELDDPPLDALGDGDSPDVDSLQASIQELFHPQEQPVETQEMSWFDDQYAPTTLK	782.2898385	1.896290897	0.534855452	3.545426882	0.000391978	0.003189888
GGCTCAGATTCA	0.123810939	0.943885889	EMC	cnn	Is known to be	LSDFDFALSMDPWNPDTTSLEPEEGTQDTAEGISDAGSPPVEDILELISRDTSPHCTGSNDAIDMFFSTLTEWEMWDGILPVIPG	1714.062031	2.360451125	0.824067256	2.864391355	0.004178115	0.026615342
													GGTAACGGACCT	0.112081539	0.944720487	EMC	xgb	Random arrangement	APPFTRNMSDTVHDYSGGAPIYEWDHTQEQEAQEPIDLGEPHEWHDYEPSMLWYQYWPGMDFHDIVGPQEDDEWLGLDIFESTLL	1876.719179	1.226967288	0.406690711	3.016954299	0.002553283	0.017130867
ACGCCATCTTTG	0.108043609	0.945134648	EMC	Both of them	Is known to be	TGGLATTTPDFTINLDGDWFPVEAFVSADRLDSPSLFSGALSPEAMPICPDLLDELMLEGADVWMQDCGQIDSFTLFDDKVSCFM	2451.496571	2.168653815	0.523747824	4.140645015	3.46E-05	0.000336552
													GTTCCCTGGAGG	0.09778175	0.945134648	EMC	xgb	Is known to be	YGEMVNGFGDFADACPCDDLMGPTYVTDHPLPPGWEQRVDLLPEDWGTDTPPATPSSEMPMPFSDNDPDMTLEQLWGIFSDIIMG	3516.107895	1.489778939	0.405926403	3.670071542	0.000242483	0.00205778
CTCAGCTCCTTG	-0.091591189	0.945208758	EMC	Both of them	Is known to be	VTPLGSSPWYGDGNHLEEDFLKTNVTQPVEDEWYVVDCDVGPDLLGLETQALEPAMDLWDMGTLLDNFMLGGPEPTADICIIDQV	5569.362324	1.670051908	0.276357855	6.043077397	1.51E-09	2.43E-08
													ATGGGATACGAC	0.129209775	0.946615625	MH	xgb	Random arrangement	EMSMEPMDASDRPLFSGLEITNMCTMSNEHLYWSDALESAHDANLINICDDLTITPNAAQDGEWDPWYDQVWQDGNIRMFDWMNV	1135.551552	1.79498866	0.543031671	3.305495342	0.000948087	0.007065742
CTGAATCTCCGA	0.129054318	0.946615625	EMC	xgb	Is known to be	DSSHSGHGGWGGVDALGDFDEPPITSVDSILWWVNDTMQTIFPEAAICDTDIPDPGLLWPMPMPSPPPPDWEFEMDHLESMNISQ	737.5421913	1.676302664	0.525350059	3.190829877	0.001418648	0.010101751
													CCCACGTGACCA	0.089386726	0.946630362	EMC	Both of them	Is known to be	NLGYGGPPEDCMYEEIAGLEDDLWTNFTNWEPVTPVDLSDLNNLLWAPPYTEDALLMDFMSLTPGGMDGLANWLLGLDPPNSAVP	2982.969573	0.830268771	0.2647496	3.136052974	0.001712383	0.011936102
AGGCCAGTTCAA	0.109212935	0.948669104	EMC	xgb	Random arrangement	DTETRDTSREWPSGIITQEFTAAQPEVPSVHSNCDNSPYEDMGMGDSEHTPFEFDNEWALDHHDWGDLDVNPYNFCDFFAPCTDP	901.0746968	2.621851192	0.740502866	3.540636116	0.000399164	0.003221961
													CTCCGTGCGAGC	-0.118647707	0.950608654	EMC	Both of them	Is known to be	SEMVSDDSSATEEHGQEIPLEIDDLYEALGQPVIAPLDPWTMCGEELLWDLGDLAELLDPGECYQHKGGDGGGQDMGPVPWFMIA	962.3261616	2.116205299	0.559472155	3.782503347	0.000155259	0.001359476
TTATATTAAGAT	0.112562661	0.951029653	EMC	Both of them	Is known to be	VTVTNPPGAEMMDSNPDIWDLEVPQIDDLSEILDEMLTDDLWDTIWSDIDTEDVCNGGWTLCQPLEYPNYAGYGLSQDTGDGWPG	1037.076639	1.815717774	0.643359211	2.82224571	0.004768862	0.029841518
													GTAATCGATCTC	0.101363765	0.952730739	EMC	xgb	Is known to be	PQDILSVLPGIDDLFQLLLETEYVFDSTHFEDANNEMDLAAASAPEGQAVMPSPEQEPVLSPSDLFAEHELPTYFQGTINWYGKG	2030.767961	1.507550283	0.414954433	3.633050191	0.000280091	0.002356755
TCACGGCAAATT	0.105826615	0.952730739	MH	xgb	Random arrangement	APPKGVIDGEQSAEDAAWIDWFPLPFSLHPVTDHCFGEWDIDDWEEPLPMVQPEQDQLWKHAAAESWWENTNVDWALFQPGYTGN	1736.083832	1.322401456	0.428978455	3.082675696	0.002051486	0.014081945
													GGCGTTCGAACC	0.079603449	0.953703029	EMC	xgb	Is known to be	GEDGEAGITMEGCDLLSGPTLGDDNPYSERDFDLFWMTADWDMQDDSMLTPEIISMCLPIGPHLEMGQLEGTSDEPHIFDVPTGL	2720.642336	1.958706353	0.390523834	5.015587222	5.29E-07	6.44E-06
CGCGACCCTCGA	-0.08789682	0.954528626	EMC	Both of them	Is known to be	VHFMEELVPDWPTWQDNGPFFLIPHVLDTNLFPPSHNEPSAEDELLDLDNPAKLFPDVDFPQFVPQPFTYTWPQELEDLLTYDHI	1890.310077	1.03576394	0.338101419	3.063471139	0.002187853	0.014955862
													GACTTCAAGCGG	0.174537037	0.954528626	EMC	xgb	Is known to be	DSPCNLVGSPNMDDNPLIDLLQGYDLMQDDEFLDHGALDDLWATILSDVYPWDEPDRGLPGENMGGTGGLQTFATSLPTGASGAF	582.982711	1.991313977	0.68995804	2.886137798	0.003900014	0.025069348
ATACTCAGACTG	-0.107063453	0.95628508	EMC	Both of them	Random arrangement	CESPQIQPGDAQMGSPSVWHDCTVTEEWSTIPYVDAMIMQDITQSHMDVIAPPPPLAAHPSIWGEIADGAPDWMVAAWDEFTNYL	2091.014773	2.855949655	0.519816176	5.494153098	3.93E-08	5.45E-07
													TCTCTTCCAGGA	0.088026273	0.95699198	EMC	Both of them	Is known to be	MPEAKPHTSAILPSWPMCPCEVHSLVEDQRQEGPPMTPGVLQQIENLDSAPGLFNLDNWFTEFDLFRLDNEVYEFLGILPQEEMY	2024.635036	1.927146854	0.404658695	4.762400707	1.91E-06	2.18E-05
TCAGTGGCAACG	0.063084249	0.963959981	EMC	cnn	Is known to be	PMPLEPGMPGDFEGPPHPVDFEPSPQRCSPNPPQYLYLDLPDDDTYLLPDLGNLFETDDIQLMDMTPTPMWLDYLDIDGMSSVWR	2792.897775	2.134777615	0.318554436	6.701453102	2.06E-11	3.95E-10
													CGACGAAGGGCG	0.068050737	0.964130373	EMC	Both of them	Random arrangement	PGYEHNDNQGGGPDPCASAYGEGEHVECQVVREALKPCAWSMAETTNIYQPPSNFDDLPMNWLAPLDYGTLHMWDDDQMDHWWDF	2433.745371	2.514062317	0.697606871	3.603838236	0.000313552	0.002616103
TTTGATGTCTTA	-0.054335773	0.971246383	EMC	xgb	Random arrangement	PATVDTSYPFGPTEDMAPALYEAITLSDEPGDSPTPTNDGSECAPPAWDQDNLPWTLDFFLNHKMYWDHMIFNQDDQEVWDCDLQ	7585.859736	1.973985264	0.25215172	7.828561578	4.93E-15	1.29E-13
													ACAAGGTAATTG	0.055797001	0.9718663	EMC	xgb	Is known to be	DDCGANSDIDSQYTAEEFFNYSEWEALNMLLERCNFDAFWDLGTENLSDMFSLLGTEALGPHGGLMDGGGEGMGLGGGGSGGGAL	425.6472243	2.869162577	0.877397587	3.270082595	0.001075161	0.007917529
AGCCGGAACAGT	-0.049432068	0.974181918	EMC	cnn	Random arrangement	GCETDVAELNANDGPKPYPPEDEYNCDTPIMYGLTTSFHDHTTLTQAQPPAQHDDPAAMEFMFDNFNDFMNSYIDTWTSSDIAIC	2799.604954	1.307542551	0.304053685	4.300367386	1.71E-05	0.000171067
													CATATTGAAAAC	-0.077641288	0.974181918	EMC	cnn	Is known to be	GGPVQSQSADMWWDTLFPDVPMEDFEPEATEYTHGQVATMMHEPCTLDPYKDIMSPDPDAAFPIMLASFDETVGLNLQCMFPELP	801.8187173	1.939005928	0.533781732	3.63258203	0.000280599	0.002357034
CTCGGGCCGGGT	0.063369678	0.974805629	EMC	xgb	Is known to be	GGGGMPAMGDHLSDVGMDFDLDMLLSNGAELPRTSDCEFGLHDLLLPLLRESSSVYPLDLGTVQDLMPTRGSVDGGGFDYGGSDA	1279.317008	2.989468704	0.570537879	5.239737475	1.61E-07	2.07E-06
													AATCAAACGGCG	0.078095914	0.978086751	EMC	Both of them	Is known to be	RAALDIEVPLGTWSGTTQLDMEECWDMIPDVDEFYTFEDFFQDFLDSLSPSPDANLCDSLAMFAGSENDEAMMDGESMQNEDRGL	1682.64982	2.991411322	0.54200408	5.519167531	3.41E-08	4.76E-07
AGTCAATTTGTA	0.039958999	0.978968472	EMC	xgb	Is known to be	PPGEDCEVPASWTREQPVRASRGVGEHSSDVPSEVTNSISWDDIDELLNSWVSPWLSLSPTPYDFTNFNLEPEELDIDHFDWVYA	3730.356702	0.940431665	0.290184367	3.240807476	0.001191917	0.008610989
													GGAGTCGCCGTT	-0.038584031	0.979158812	EMC	Both of them	Random arrangement	AMAFTEELMDNTLDDITNHVFPYPLTEDWLDMYVLGDMLNMIEMPDILAGDLQFIPHEFANPCGPQHDFQAPPMTHESARWQWDD	4345.718315	1.691360015	0.34685006	4.876343446	1.08E-06	1.26E-05
TTGGGTCAGGAA	0.056988207	0.983105362	EMC	xgb	Is known to be	DESDLSLAAPIPNILDPPSDVHPYDEAVMEGDVDAGDLSLHNPPDLDDLYSDEIQEAMWSNETWDTGSPLYPFDAALLDAIFQGS	672.8901405	3.058028978	0.459806818	6.650682104	2.92E-11	5.50E-10
													TGCGCGCTCTCA	0.027377458	0.985972545	EMC	Both of them	Random arrangement	CAAPEGVEFDIDYPWDNVLPNVHAMEVHQSFPLPPMDPFDLQDPNEEQVPPSMSWEPYELIEFWDSIANWQHESPGIMLTFENSG	4886.088068	1.083004155	0.30420381	3.560126867	0.000370676	0.003046548
GCCTCCATCTCC	0.04618398	0.987195653	EMC	Both of them	Random arrangement	DGVQAQAFPDAKWLDCLWPLLDDWDWCHDPTISYGSPFAPSDMTELDLCQDDWTLMEFLAGVPDMSPPEASNIDSSGDKENMDWC	680.1289921	2.416402417	0.849127618	2.845747053	0.004430737	0.027972911
													TGCGAACGACCT	0.026701051	0.991080426	EMC	Both of them	Is known to be	ADPDYSVDLLADQELFNEFNTMWGDFDDFWGWPCTPPGALAIPNSLPSALPDNDTHTMADFEADPYAISGLLSWCMGPGLQQAEY	2730.141688	2.635285296	0.6031528	4.369183558	1.25E-05	0.000126914
TTTCCCTGACGC	0.019259954	0.991080426	EMC	cnn	Is known to be	PPTQQNLEADEDIHNNFILDPEPPSPGVSDNWPYMPLPHSVLPPQDSPLTPYLNYITDGQLNMEMYAEFGPFSWTDLDECCGGQC	7152.204529	2.626756823	0.388907857	6.754188114	1.44E-11	2.84E-10
													ACCGCAACCTAT	0.01437591	0.994750304	EMC	cnn	Is known to be	PMPLSGAADRDNDDAEEYFPISEEEALTQLLELNNWDAFLDLMTEMLSDMPMGGEEATTVQLHGGPMGPVPLLGADLFDHFGDDA	2188.778491	1.172261331	0.317784447	3.688856844	0.000225264	0.001924841
GAGATCCGTAAC	0.021377799	0.994750304	EMC	xgb	Is known to be	LPGEQSAEDSHIWPRYMGPSPSLDSQPHPFDEDKSYTALFSHEPRIFDLPSLDTEWLADLGEMDCAAFMDELEDMGFTLGSGTLP	3355.34538	2.439445339	0.395441125	6.168921711	6.88E-10	1.14E-08
													CACGGTTTGAGC	-0.015136782	0.994842464	EMC	cnn	Is known to be	ETPDLFDVDMPLTPTDDVLVRWILDNDGEHDAPMPLWTPSSFSELDTSDWGIPSPFVGEYDEWQNYMASMTNNITGGGGDEKGEY	1855.147846	3.019922449	0.557826394	5.413731731	6.17E-08	8.29E-07
GAGTTTCAGAAG	0.048836342	0.994842464	EMC	xgb	Is known to be	MFDFEDWTPFDLDPGLPWSGATPTEVLPMVLHSEGQTPDLLSDWEQTLPDLGDPLALCNNTFDDFSDSTWLSIATGGWHMDPVLF	208.1416009	2.723348907	0.944743183	2.882634092	0.003943652	0.025284271
													TCTTGTGGACAC	0.016470245	0.994842464	EMC	Both of them	Is known to be	QYPLEPHSDDPTVDMSSGDTVPLDVEPLYEGTFWTPGPVLQDFLSWFETPNPAPNNAYQEQWGNWLEGFCENPPYSESFNHPQDG	2465.066019	1.764150488	0.355487799	4.962618952	6.95E-07	8.33E-06
TTATAAGGTAAG	0.017896687	0.994842464	EMC	Both of them	Random arrangement	EPDQGNAPDIFMPSDHEENPEVHEYDIMALMQDFPTGVAAGPTISLPCGLHGACPCYLGWDDSAFNEEPLCMDLNLDDVMREAQY	960.6384366	3.021497096	0.645043364	4.684176696	2.81E-06	3.10E-05
													GGGGGCTTTCTC	-0.004857212	0.998274374	EMC	xgb	Is known to be	TNHALYCDCVKEGTPYVQPQEHPRPPEAEDSWTDVFLLDDKGYADIYDLLDPGSEQFNSMDLPPSFELGEGTWDDEGGIGTTSHV	1938.330705	1.532771506	0.429876814	3.565606372	0.000363016	0.002993522
ATCCCGACACAC	-0.002690239	0.999193785	EMC	Both of them	Random arrangement	ADDHFDHIIAEMAHTFVCNCNPNCPPENPNIFLPPTQEHHDLLDMWHNDSFECLSGLEMNPFVFGPLETPDYEWASFMPMDDNPD	3392.326115	1.379735382	0.275205089	5.013480624	5.35E-07	6.49E-06

Claims (93)

1. An engineered gene effector, the effector comprising a polypeptide comprising:

A first peptide of 75-110, or 75-95 amino acids in length, wherein the first peptide comprises any one of SEQ ID NOs 3-100, or a sequence at least 85% identical thereto, and

A second peptide of 75-110, or 75-95 amino acids in length and heterologous to the first peptide, wherein the second peptide comprises any one of SEQ ID NOs 3-100, or a sequence at least 85% identical thereto, optionally wherein the first peptide is different from the second peptide.

2. The engineered gene effector of claim 1, wherein the first peptide and/or the second peptide is 85 or 108 amino acids in length, optionally wherein the first peptide and the second peptide are each 85 or 108 amino acids in length.

3. The engineered gene effector of claim 1 or 2, wherein the first peptide comprises any one of SEQ ID NOs 3-100 with 0-3 amino acid residue mutations and/or the second peptide comprises any one of SEQ ID NOs 3-100 with 0-3 amino acid residue mutations, optionally wherein any mutation thereof is a conservative substitution.

4. The engineered gene effector of claim 1 or 2, wherein the first peptide comprises any one of SEQ ID NOs 3-100 and/or the second peptide comprises any one of SEQ ID NOs 3-100.

5. The engineered gene effector of any one of the preceding claims, wherein the first peptide is located N-terminal to the second peptide, wherein any one of SEQ ID NOs 3-100 of the first peptide comprises SEQ ID NOs 3-100, and wherein any one of SEQ ID NOs 3-100 of the second peptide comprises SEQ ID NOs 3-100.

6. The engineered gene effector of claim 5, wherein the first peptide and the second peptide are arranged in pairs according to any one of the SEQ ID NOs of the first peptide and the second peptide listed in table 4, wherein the first peptide is located at the N-terminus of the second peptide.

7. The engineered gene effector of any one of the preceding claims, wherein the first peptide and the second peptide are linked by a linker, optionally wherein the linker comprises any one or more of SEQ ID NOs 2211-2221, optionally wherein the linker comprises SEQ ID NO 2211.

8. The engineered gene effector of any one of the preceding claims, wherein the polypeptide comprises any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence at least 85% identical thereto.

9. The engineered gene effector of claim 7, wherein the polypeptide comprises any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451 having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

10. The engineered gene effector of any one of the preceding claims, wherein the polypeptide comprises any one of SEQ ID NOs 1085, 122, 1084, 653, 1099 and 1107, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

11. The engineered gene effector of any one of the preceding claims, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, optionally wherein the target gene is endogenous to the cell.

12. The engineered gene effector of claim 11, wherein the target gene is a silenced gene, optionally wherein the silenced gene is a methylated gene.

13. The engineered gene effector of claim 11 or 12, wherein the engineered gene effector is capable of increasing, or increasing by at least or about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 250%, 300%, 400%, 500% the expression level of the target gene, optionally wherein the engineered gene effector is capable of increasing the expression level of the target gene by a percentage within a range defined by any two of the foregoing values, e.g., 10% -100%, 100% -200%, 200% -400%, 250% -500%, 10% -50%, 50-100%, etc.

14. The engineered gene effector of any one of the preceding claims, wherein the polypeptide is coupled to a heterologous endonuclease, optionally wherein the heterologous endonuclease is a Cas protein.

15. The engineered gene effector of claim 14, wherein the heterologous endonuclease is, at most, or about 450, 460, 470, 480, 490, 500, 520, 540, 560, 580, 600, 620, 640, 660, 680, 700 amino acids in length, optionally wherein the heterologous endonuclease is within a range defined by any two of the foregoing values, e.g., 450-700 amino acids, 480-600 amino acids, 500-530 amino acids, 500-600 amino acids, etc.

16. The engineered gene effector of claim 14 or 15, wherein the heterologous endonuclease comprises the amino acid sequence of any one of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

17. The engineered gene effector of any one of claims 14-16, wherein the polypeptide is fused to the heterologous endonuclease.

18. The engineered gene effector of claim 17, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

19. An engineered gene effector, the effector comprising a polypeptide comprising:

A first peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator, and

A second peptide comprising an amino acid sequence of 75-110 amino acids in length and based on a human or viral transcriptional regulator, wherein the second peptide is heterologous to the first peptide, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene.

20. The engineered gene effector of any one of the preceding claims, wherein the first peptide and/or the second peptide has a beta factor of about 30 to about 65.

21. The engineered gene effector of any one of the preceding claims, wherein the first peptide and/or the second peptide is enriched in a negative electrostatic potential.

22. The engineered gene effector of any one of the preceding claims, wherein the first peptide and/or the second peptide has a negative net charge.

23. The engineered gene effector of any one of the preceding claims, wherein the engineered gene effector is capable of activating a target gene in a cell, wherein the target gene expression level activated by the engineered gene effector lasts for a period of time that is, about or at least 9 days, 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days or longer, or optionally, the expression level lasts for a period of time that is within a range defined by any two of the foregoing values, e.g., 9-18 days, 9-14 days, 12-18 days, 14-16 days, etc.

24. The engineered gene effector of any one of the preceding claims, wherein the engineered gene effector is capable of activating a target gene in a cell, wherein the expression level of the target gene is increased by at least 0.1-fold, 0.2-fold, 0.3-fold, 0.4-fold, 0.5-fold, 0.6-fold, 0.7-fold, 0.8-fold, 0.9-fold, 1-fold, 1.5-fold, 2-fold, 2.5-fold, 3-fold, 5-fold, 10-fold, 20-fold, 30-fold, 40-fold, 50-fold or more, or optionally the expression level of the target gene is increased by a factor within a range defined by any two of the foregoing values, e.g., 0.1-50-fold, 0.5-10-fold, 1-40-fold, 2-30-fold, etc., as compared to a control.

25. A fusion protein, the protein comprising:

The engineered gene effector of any one of the preceding claims, and

A heterologous endonuclease coupled to the polypeptide, optionally, wherein the heterologous endonuclease is a Cas protein.

26. The fusion protein of claim 25, wherein the heterologous endonuclease comprises the amino acid sequence of any of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

27. The fusion protein of claim 25 or 26, wherein the polypeptide is fused to the heterologous endonuclease.

28. The fusion protein of claim 25, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

29. A polynucleotide comprising a nucleotide sequence encoding the engineered gene effector or fusion protein of any one of the preceding claims.

30. A vector comprising the polynucleotide of claim 29.

31. A cell comprising the polynucleotide of claim 29 or the vector of claim 30.

32. A system, the system comprising:

the engineered gene effector of any one of claims 1-24;

A heterologous endonuclease coupled to said polypeptide of said engineered gene effector, optionally wherein said heterologous endonuclease is a Cas protein, and

A guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell.

33. The system of claim 32, wherein the heterologous endonuclease comprises an amino acid sequence of any of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

34. The system of claim 32 or 33, wherein the polypeptide is fused to the heterologous endonuclease.

35. The system of claim 34, wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

36. A combination of polynucleotides encoding the system of any one of claims 32-35, wherein the combination of polynucleotides is configured to express the heterologous endonuclease coupled to the engineered gene effector and the guide nucleic acid in a cell.

37. A kit comprising the engineered gene effector, fusion protein, combination, system, polynucleotide, vector, and/or cell of any one of the preceding claims.

38. A method of controlling a target gene in a cell, the method comprising contacting the cell with the engineered gene effector of any one of claims 1-24, the fusion protein of any one of claims 25-28, the polynucleotide of claim 29, the vector of claim 30, the system of any one of claims 32-35, or the combination of polynucleotides of claim 36.

39. The method of claim 38, wherein the target gene is endogenous to the cell.

40. The method of claim 38 or 39, wherein the contacting is performed in vitro or ex vivo.

41. A computer-implemented method of generating a functional biological sequence, the method comprising:

(a) Providing an fitness function trained on a biological data set, the biological data set comprising functionally determined biological sequences having a fixed length;

(b) Providing in the computer a plurality of different sequences comprising a fixed length, each sequence being associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of a temperature gradient;

(c) By the computer, in parallel in the plurality of different sequences:

(1) Selecting one or more random positions for introducing substitutions in one or more of said plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and

For each of the one or more sequences, evaluating a first fitness change resulting from the introduction of the substitution at the one or more randomly selected locations and accepting or rejecting the substitution based on the evaluated first fitness change and optionally further based on the temperature associated with the sequence, and/or

(2) Selecting one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a successive temperature of the temperature gradient, optionally selecting up to 3 pairs of the plurality of different sequences, optionally selecting 1 pair of the plurality of different sequences, and

For each of the selected pairs:

Selecting one or more domains for exchange between the sequences of the selected pair, and

Evaluating the difference in fitness of the sequences of the selected pair due to the exchange of the one or more domains, and

Accepting or rejecting the one or more domain exchanges between the selected pairs based on the fitness differences and the temperatures associated with each sequence of the selected pairs, and

(D) Iteratively performing (c), wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domains of a previous iteration are swapped into the plurality of different sequences,

Thereby producing one or more functional sequences having fitness at or above a desired fitness threshold.

42. The method of claim 41, comprising accepting, at (c) (1), the substitution at the one or more randomly selected locations when the fitness of the sequence after the substitution is introduced is greater than the fitness of the sequence before the substitution is introduced.

43. The method of claim 41 or 42, comprising, at (c) (1), accepting or rejecting the substitution at the one or more randomly selected locations based on a probability weighted by a ratio of the fitness of the sequence after the substitution is introduced to the fitness of the sequence before the substitution is introduced.

44. The method of any one of claims 41-43, comprising, at (c) (1), accepting or rejecting the substitution at the one or more randomly selected locations based on Boltzmann Metropolis-hastins acceptance criterion r _mh.

45. The method of any of claims 41-44, wherein the one or more randomly selected locations are selected uniformly across the fixed length.

46. The method of any one of claims 41-45, comprising, at (c) (2), accepting an exchange of the selected domain between the selected pair when the fitness of the sequence associated with a lower of the consecutive temperatures after exchange is greater than the fitness of the sequence associated with a higher of the consecutive temperatures after exchange, optionally wherein the selected domain comprises the complete sequence of the selected pair.

47. The method of any one of claims 41-46, comprising, at (c) (2), accepting an exchange of the selected domain between the selected pairs based on a probability inversely proportional to a difference between the temperatures associated with each sequence of the pairs, and a ratio of the fitness of the sequence pairs after exchange, optionally wherein the selected domain comprises the complete sequence of the selected pair.

48. The method of any one of claims 41-47, comprising, at (c) (2), accepting or rejecting an exchange of the selected domain between the pair based on parallel tempering criterion r _re, optionally wherein the selected domain comprises the complete sequence of the selected pair.

49. The method of any one of claims 41-48, wherein (c) comprises:

(3) Selecting a crossover site between one or more pairs of said plurality of different sequences, and

For each of the one or more pairs in which the crossover site is selected, a second fitness change for each sequence of the selected pair resulting from crossover at the crossover site is evaluated, and crossover at the selected crossover site is accepted or rejected based on the second fitness change and the temperature associated with each sequence of the selected pair.

50. The method of claim 49, comprising accepting or rejecting crossover at the selected crossover site based on a probability weighted by a ratio of the second fitness change for each of the sequences of the selected pair.

51. The method of any of claims 41-50, wherein at least one of the generated one or more functional sequences has a fitness based on the fitness function that is greater than a fitness of each of the plurality of different sequences prior to any iteration of (c).

52. The method of any of claims 41-51, wherein the desired fitness threshold is based on fitness associated with a corresponding sequence of the plurality of different sequences in (b), optionally wherein the desired fitness threshold is based on a maximum fitness among the plurality of different sequences.

53. The method of any one of claims 41-52, wherein the plurality of different sequences in (b) comprises a plurality of different, naturally occurring sequences.

54. A computer-implemented method of generating a functional biological sequence, the method comprising:

(a) Evaluating, by a computer, sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functionally determined biological sequences having the fixed length;

(b) Replacing, by the computer, one or more random residues in the sequence to generate a mutated sequence;

(c) Evaluating, by the computer, the mutant sequence based on the fitness function, and

(D) The functional sequences accepted by the fitness function are collected by the computer.

55. The computer-implemented method of claim 54, further comprising randomly exchanging, by a computer, one or more subsequences from the mutant sequence with different sequences of the plurality of sequences.

56. The computer-implemented method of claim 54 or 55, wherein the fitness function comprises a threshold selected from the group consisting of a binary threshold, a numerical threshold, a multi-class threshold, a confidence threshold, a decision threshold, and any combination thereof.

57. The computer-implemented method of claim 56, wherein a functional sequence is accepted by the fitness function when a fitness score assigned to the functional sequence by the fitness function exceeds the threshold.

58. The computer-implemented method of any one of claims 54-57, wherein the plurality of different sequences in (a) comprises a plurality of different naturally occurring sequences or different random sequences.

59. The computer-implemented method of any one of claims 41-58, wherein the functionally defined biological sequence comprises an amino acid sequence or nucleotide sequence of a protein or peptide, or an amino acid sequence or nucleotide sequence encoding a protein or peptide, optionally wherein the functionally defined biological sequence comprises a transcriptional activator, further optionally wherein the functionally defined biological sequence comprises an engineered gene effector.

60. The computer-implemented method of claim 59, wherein said protein or said peptide is an epigenetic regulator, a transcription factor, an enzyme, a nuclease, an agonist, an antagonist, a regulatory factor, or an inhibitor.

61. The computer-implemented method of any one of claims 41-60, wherein the functionally determined biological sequence comprises an amino acid sequence or a nucleotide sequence.

62. The computer-implemented method of any one of claims 41-61, wherein the functionally defined biological sequence comprises an amino acid sequence, and further wherein the fixed length is at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60, at least 65, at least 70, at least 75, at least 80, at least 85, at least 90, at least 95, at least 100, at least 105, at least 110, at least 115, at least 120, at least 125, at least 130, at least 140, at least 150, or at least 200 amino acids, or at most 500, at most 300, at most 200, at most 150, at most 120, at most 100, at most 95, at most 90, at most 85, at most 75, or at most 70 amino acids, or optionally wherein the fixed length is within a range defined by any two of the foregoing values, e.g., 30-500 amino acids, 50-300 amino acids, at least 150-200 amino acids, 75-150 amino acids, or the like.

63. The computer-implemented method of any of claims 41-62, wherein the fitness function is based on one or more machine learning models, wherein the machine learning model is selected from the group consisting of a supervised machine learning model, an unsupervised machine learning model, a reinforcement learning model, a deep learning model, a transfer learning model, and any combination thereof.

64. The computer-implemented method of claim 63, wherein the one or more machine learning models are selected from the group consisting of a classification model, a regression model, a decision tree model, a Convolutional Neural Network (CNN), a Recurrent Neural Network (RNN), a limiting gradient boost (XGBoost), a long and short term memory network, a Generative Antagonism Network (GAN), an automatic encoder, a transformer network, an evolutionary Monte Carlo, and any combination thereof.

65. The computer-implemented method of claim 64, wherein the fitness function is based on an integrated model comprising a decision tree model and a convolutional neural network, optionally wherein the integrated model comprises CNNs and XGBoost.

66. The computer-implemented method of any of the preceding claims, the method comprising evaluating, by the computer, the biological data set to generate the fitness function, the evaluating comprising:

Generating a sequence embedding from a Large Protein Language Model (LPLM) based on the biological dataset, and

Training a machine learning model with the generated sequence embedding as input, optionally wherein the LPLM comprises an Evolutionary Scale Modeling (ESM) language model, optionally wherein the LPLM comprises ESM-2.

67. The computer-implemented method of claim 66, wherein the machine learning model comprises an integrated model of more than two different models.

68. The computer-implemented method of claim 67, wherein said integrated model comprises CNNs and XGBoost.

69. The computer-implemented method of any of the preceding claims, wherein the plurality of different sequences comprises a plurality of different random sequences.

70. The computer-implemented method of any of the preceding claims, wherein the biological dataset comprises up to about 10 ⁵ biological sequences or biological sequences on the order of about 10 ⁵ biological sequences.

71. The computer-implemented method of any one of the preceding claims, wherein up to 5% of the functionally determined biological sequences comprise functional sequences.

72. A computer-implemented system comprising a computing device comprising at least one processor and instructions executed by the at least one processor to provide an application, the application comprising:

(a) A software module configured to evaluate, by a computer, a sequence of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological data set, the biological data set comprising a functionally determined biological sequence having the fixed length;

(b) A software module configured to replace, by the computer, one or more random residues in the sequence to generate a mutated sequence;

(c) A software module configured to evaluate, by the computer, the mutant sequence based on the fitness function, and

(D) A software module configured to collect, by the computer, a sequence of functionalities accepted by the fitness function.

73. A non-transitory computer readable medium having stored thereon computer readable instructions that, when executed by a processor, cause the processor to perform a method comprising:

(a) Evaluating sequences of a plurality of different sequences comprising a fixed length based on an fitness function trained on a biological dataset comprising functionally determined biological sequences having the fixed length;

(b) Replacing one or more random residues in the sequence to generate a mutated sequence;

(c) Evaluating the mutant sequence based on the fitness function, and

(D) Functional sequences accepted by the fitness function are collected.

74. A computer-implemented system comprising a computing device comprising at least one processor and instructions executed by the at least one processor to provide an application comprising one or more software modules for performing the method of any of claims 41-71.

75. A non-transitory computer readable medium having stored thereon computer readable instructions which, when executed by a processor, cause the processor to perform the method of any of claims 41-71.

76. An engineered gene effector comprising one or more polypeptides produced by the method of any one of claims 41-71, or a sequence at least 85% identical thereto.

77. An engineered gene effector comprising a polypeptide of 85 amino acids in length comprising any one of SEQ ID NOs 1495, 1592, 1595, 1634, 1654, 1665, 1677, 1686, 1689, 1716, or a sequence at least 85% identical thereto.

78. The engineered gene effector of claim 76 or 77, wherein the engineered gene effector is capable of activating a target gene in a cell when the engineered gene effector is expressed in the cell and is effective to target a site of the target gene, optionally wherein the target gene is endogenous to the cell.

79. The engineered gene effector of any one of claims 76-78, wherein the polypeptide is coupled to a heterologous endonuclease, optionally wherein the heterologous endonuclease is a Cas protein.

80. The engineered gene effector of claim 79, wherein the heterologous endonuclease comprises the amino acid sequence of any of SEQ ID NOs 2222-2422, or a sequence at least 85% identical thereto.

81. The engineered gene effector of claim 79 or 80, wherein the polypeptide is fused to the heterologous endonuclease, optionally wherein the polypeptide is fused to the C-terminus of the heterologous endonuclease.

82. A fusion protein, the fusion protein comprising:

the engineered gene effector of any one of claims 76-81, and

The heterologous endonuclease coupled to the polypeptide, optionally, wherein the heterologous endonuclease is a Cas protein.

83. A polynucleotide comprising a nucleotide sequence encoding the engineered gene effector of any one of claims 76-81 or the fusion protein.

84. A vector comprising the polynucleotide of claim 83.

85. A cell comprising the polynucleotide of claim 83 or the vector of claim 84.

86. A system, the system comprising:

the engineered gene effector of any one of claims 76-81;

Optionally, a heterologous endonuclease coupled to the engineered gene effector, wherein the heterologous endonuclease is a Cas protein, and

A guide nucleic acid capable of forming a complex with the heterologous endonuclease, wherein the complex exhibits specific binding to a target gene in a cell when the system is expressed in the cell.

87. A combination of polynucleotides encoding the system of claim 86, wherein the combination of polynucleotides is configured to express the heterologous endonuclease coupled to the engineered gene effector and the guide nucleic acid in a cell.

88. A method of controlling a target gene in a cell, the method comprising contacting the cell with the system of claim 86 or the combination of polynucleotides of claim 87.

89. The method of claim 88, wherein the target gene is endogenous to the cell.

90. The method of claim 88 or 89, wherein the contacting is performed in vitro or ex vivo.

91. A computer-implemented system comprising a computing device comprising at least one processor and instructions executed by the at least one processor to provide an application, the application comprising:

(a) A software module configured to provide, by a computer, an fitness function trained on a biological data set, the biological data set comprising a functionally determined biological sequence having a fixed length;

(b) A software module configured to provide, by the computer, a plurality of different sequences comprising a fixed length, each sequence associated with a temperature and a fitness based on the fitness function, wherein each sequence is associated with a different temperature of a temperature gradient;

(c) Parallel in the plurality of different sequences:

(1) A software module configured to select, by the computer, one or more random positions for introducing substitutions in one or more of the plurality of different sequences, optionally 1-5 random positions, optionally 1 random position, and

For each of the one or more sequences, evaluating a first fitness change resulting from the introduction of the substitution at the one or more randomly selected locations and accepting or rejecting the substitution based on the evaluated first fitness change and optionally further based on the temperature associated with the sequence, and/or

(2) A software module configured to select, by the computer, one or more pairs of the plurality of different sequences, each selected pair comprising a sequence associated with a successive temperature of the temperature gradient, optionally at most 3 pairs of the plurality of different sequences, optionally 1 pair of the plurality of different sequences, and

For each of the selected pairs:

Selecting one or more domains for exchange between the sequences of the selected pair, and

Evaluating the difference in fitness of the sequences of the selected pair due to the exchange of the one or more domains, and

Accepting or rejecting the one or more domain exchanges between the selected pairs based on the fitness differences and the temperatures associated with each sequence of the selected pairs, and

(D) A software module configured to be executed iteratively by the computer (c), wherein in each subsequent iteration, accepted substitutions of a previous iteration and/or accepted domains of a previous iteration are swapped into the plurality of different sequences, thereby producing one or more functional sequences having fitness that meets or is above a desired fitness threshold.

92. An engineered gene effector comprising a polypeptide comprising any one of SEQ ID NO: 115-274、276-287、289-367、370-445、448-746、748-777、779-929、931-1007、1009-1156、1158-1194、1196-1288、1290-1350、1352-1451, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally wherein any mutation thereof is a conservative substitution.

93. An engineered gene effector comprising a polypeptide comprising any one of SEQ ID NOs 1085, 122, 1084, 653, 1099 and 1107, or a sequence at least 85% identical thereto, or a sequence having a mutation of 0-3 amino acid residues, optionally, wherein any mutation thereof is a conservative substitution.