CN1211113C - Preparation to be taken after being mixed with boiling water for easy to release symptom of cough and asthma caused by SARS and its prepn. method - Google Patents

Abstract

The present invention relates to a deep-processing product of Chinese herbal medicine, particularly to a cough and dyspnea relief granule for relieving SARS symptoms and a preparation method of the cough and dyspnea relief granule. The present invention is composed of raw materials of (by weight proportion) 10 to 20 of perilla leaf, 7.5 to 17.5 of mint, 5 to 15 of Chinese mosla herb, 20 to 30 of fragrant solomonseal rhizome, 13.8 to 23.8 of radix adenophorea and 13.7 to 23.7 of platycodon root. The present invention becomes an easily taken granule by the reformation of the dosage form, and original granule extracted by decoction and concentration is changed into the process that a supercritical CO2 extractive distillation column is firstly used for extracting volatile oil, ultramicrowave is used for pulverizing starch medicine for ultramicro pulverizzation, and lotion of the three former times is extracted and mixed to be made into granules, and then, the volatile oil is proportionally sprayed into the granules. The present invention solves the problem of loss of the volatile oil, and accordingly, the medicinal effect is assured.

Description

A kind of electuary of alleviating the SARS symptom and preparation method thereof

Technical field

The present invention relates to the finely processed product of Chinese herbal medicine, refer in particular to a kind of electuary that can alleviate the SARS symptom and preparation method thereof.

Background technology

The manufacture method of motherland's traditional medicine is decocting method basically, the decocting method of all herbal medicine, it is too big that some easy evaporable active ingredients are scattered and disappeared, and significantly reduced the curative effect of medicine, and the decoction that decocts not only dose is many, active ingredient is also wayward; Owing to contain a large amount of starch in Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), the Radix Platycodonis, the starch hydroxy number is many, molecular weight is too big, so be insoluble in water, add that the gelatinizing of starch is difficult to filter, and be easy to generate a large amount of foams, cause the water concentration difficulty that contracts, can not guarantee medicine protoplasm original flavor, moreover decoction needs interim the decoction to bring the inconvenience of taking medicine to the patient.

Summary of the invention

The objective of the invention is at the problem and shortage that exists in the background technology, according to motherland's Chinese medicine scientific principle opinion, provide a kind of drugs with function in conjunction with modern manufacture method with the sore-throat relieving that dispels the wind, ascending the clear and descending the turbid, nourishing YIN to relieve dryness, relieving cough and asthma, be mainly used in atypical pneumonia (SARS) symptom and itching of the throat, dry cough without phlegm, tachypnea uncomfortable in chest, very then dyspnea with rapid and short breath unbearably, the Chinese medicine electuary of symptom such as respiratory distress and preparation method thereof.

The electuary of alleviation SARS symptom of the present invention is to be made by following materials of weight proportions:

Folium Perillae 10-20, Herba Menthae 7.5-17.5, Herba Moslae 5-15,

Rhizoma Polygonati Odorati 20-30, Radix Adenophorae (Radix Glehniae) 13.8-23.8, Radix Platycodonis 13.7-23.7

Preparation method of the present invention is as follows:

A 1), Folium Perillae, Herba Menthae, Herba Moslae are ground into 80 orders, raw material is packed into reinstalls supercritical CO behind the cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.0-1.3mpa, temperature 36-37 ℃, open rectifying column, extract the volatile oil of extraction behind the 3-3.5h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Platycodonis with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

The present invention has following advantage:

1, prescription of the present invention is the innovation core of this medicine, and prescription had both adopted the principle-method-recipe-medicines principle of traditional Chinese medicine, combines the achievement of modern pharmacological research again.From motherland's traditional medicine angle is monarch with the Folium Perillae, and Herba Menthae is a minister, and Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae) are assistant, Herba Moslae, and Radix Platycodonis reaches the effect of dispelling wind sore-throat relieving, ascending the clear and descending the turbid, nourishing YIN to relieve dryness, relieving cough and asthma for making.Press modern pharmacology effect research, Folium Perillae has bacteriostasis; Herba Menthae has anticorrosion removal throat mucus and antiinflammation; Herba Moslae contains phenolic substance and flavonoid glycoside, has antivirus action, and joining Radix Adenophorae (Radix Glehniae) has the merit of eliminating the phlegm; Four medicine combineds effect have effect preferably to the sticking discomfort of throat expectorant.Radix Platycodonis, Rhizoma Polygonati Odorati two medical instruments have the effect of blood sugar lowering, thereby have reduced heat energy in the body, reduce the stimulation of throat.During 2003 China at the beginning of the year popular SARSs, several patients suspected from Guangzhou the SARS epidemic district have taken medicine provided by the invention with heating and have had a significant effect because of throat is itched, dry cough without phlegm.

2, making electuary into from decoction is an innovation, and Chinese herbal medicine always adopts the decoction decoction, becomes a kind of electuary that is easy to take by form improvement, and the electuary from former decocting and concentrating is extracted makes to use earlier supercritical CO into ₂The extracting rectifying post extracts volatile oil, the reuse ultramicrowave is pulverized the starch based medicine is carried out micronizing, again first three liquid medicine is extracted to be mixed together and makes granule, in proportion volatile oil is sprayed in the granule then, solve this difficult problem of loss of volatile oil, thereby guaranteed drug effect.

3, the decocting method of all herbal medicine, it is too big that some easy evaporable active ingredients are scattered and disappeared, significantly reduced curative effect of medication, and itching of the throat, dry cough without phlegm one disease, main medical value is the effective ingredient by volatile oil, utilize modern extracting method, solved the shortcoming of a large amount of losses of volatile oil component.

4, reduce dose, improved curative effect.Not only dose is many for the decoction that decocts, and curative effect is low, and effective ingredient is wayward.Carry out deep processing and make electuary, need 10 gram amounts to reduce to 3 gram amounts originally, former medicine utilization rate improves 40 percent.

5, because Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Platycodonis three medicines contain a large amount of starch, and the starch hydroxy number is many, and molecular weight is too big, so be insoluble in water, add that the gelatinizing of starch is difficult to filtration, and be easy to generate a large amount of foams, cause the water concentration difficulty that contracts.Ultra-micro powder is to adopt the ultramicrowave disintegrating apparatus, has changed the original drawback of extracting with the decocting method for concentration, makes medicine guarantee the protoplasm original flavor, has improved drug effect.Not only solve water and put forward spissated difficulty, avoided extracting the pollution of back medicinal residues again.

The specific embodiment

Embodiment example one:

Take by weighing raw material (unit is gram) by following proportioning

Folium Perillae 1000, Herba Menthae 750, Herba Moslae 500,

Rhizoma Polygonati Odorati 2000, Radix Adenophorae (Radix Glehniae) 1380, Radix Platycodonis 1370

Preparation method is as follows:

A 1), Folium Perillae 1000 gram, Herba Menthae 750 grams, Herba Moslae 500 grams are ground into 80 orders, reinstall supercritical CO with the raw material dress as after going into cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.0mpa, 36 ℃ of temperature are opened rectifying column, extract the volatile oil of extraction behind the 3.1h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati 2000 grams, Radix Adenophorae (Radix Glehniae) 1380 grams, Radix Platycodonis 1370 grams with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

Embodiment example two:

Take by weighing raw material (unit is gram) by following proportioning

Folium Perillae 2000, Herba Menthae 1750, Herba Moslae 1500,

Rhizoma Polygonati Odorati 3000, Radix Adenophorae (Radix Glehniae) 2380, Radix Platycodonis 2370

Preparation method is as follows:

A 1), Folium Perillae 2000 gram, Herba Menthae 1750 grams, Herba Moslae 1500 grams are ground into 80 orders, reinstall supercritical CO with the raw material dress as after going into cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.1mpa, 36.5 ℃ of temperature are opened rectifying column, extract the volatile oil of extraction behind the 3.2h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati 3000 grams, Radix Adenophorae (Radix Glehniae) 2380 grams, Radix Platycodonis 2370 grams with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

Embodiment example three:

Take by weighing raw material (unit is gram) by following proportioning

Folium Perillae 1300, Herba Menthae 1050, Herba Moslae 800,

Rhizoma Polygonati Odorati 2300, Radix Adenophorae (Radix Glehniae) 1680, Radix Platycodonis 1670

Preparation method is as follows:

A 1), Folium Perillae 1300 gram, Herba Menthae 1050 grams, Herba Moslae 800 grams are ground into 80 orders, reinstall supercritical CO with the raw material dress as after going into cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.1mpa, 36.5 ℃ of temperature are opened rectifying column, extract the volatile oil of extraction behind the 3.3h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati 2300 grams, Radix Adenophorae (Radix Glehniae) 1680 grams, Radix Platycodonis 1670 grams with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

Embodiment example four:

Take by weighing raw material (unit is gram) by following proportioning

Folium Perillae 1700, Herba Menthae 1450, Herba Moslae 1200,

Rhizoma Polygonati Odorati 2700, Radix Adenophorae (Radix Glehniae) 2080, Radix Platycodonis 2070

Preparation method is as follows:

A 1), Folium Perillae 1700 gram, Herba Menthae 1450 grams, Herba Moslae 1200 grams are ground into 80 orders, reinstall supercritical CO with the raw material dress as after going into cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.2mpa, 36.5 ℃ of temperature are opened rectifying column, extract the volatile oil of extraction behind the 3.4h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati 2700 grams, Radix Adenophorae (Radix Glehniae) 2080 grams, Radix Platycodonis 2070 grams with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

Embodiment example five:

Take by weighing raw material (unit is gram) by following proportioning

Folium Perillae 1500, Herba Menthae 1250, Herba Moslae 1000,

Rhizoma Polygonati Odorati 2500, Radix Adenophorae (Radix Glehniae) 1880, Radix Platycodonis 1870

Preparation method is as follows:

A 1), Folium Perillae 1500 gram, Herba Menthae 1250 grams, Herba Moslae 1000 grams are ground into 80 orders, reinstall supercritical CO with the raw material dress as after going into cloth bag ₂Covered and enclosed in the extraction axe.

2), with CO ₂Pour in the axe, pressurization 1.3mpa, 37 ℃ of temperature are opened rectifying column, extract the volatile oil of extraction behind the 3.5h.

B 1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient.

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying.

C is crushed to 2000 orders with Rhizoma Polygonati Odorati 2500 grams, Radix Adenophorae (Radix Glehniae) 1880 grams, Radix Platycodonis 1870 grams with super micron mill.

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step.

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.

Claims (4)

1, a kind of electuary of alleviating the SARS symptom is characterized in that it is made by the following weight proportion raw material:

Folium Perillae 10-20, Herba Menthae 7.5-17.5, Herba Moslae 5-15,

Rhizoma Polygonati Odorati 20-30, Radix Adenophorae (Radix Glehniae) 13.8-23.8, Radix Platycodonis 13.7-23.7

2, the electuary of alleviation SARS symptom according to claim 1, wherein the weight proportion of each raw material is:

Folium Perillae 13-17, Herba Menthae 10.5-14.5, Herba Moslae 8-12,

Rhizoma Polygonati Odorati 23-27, Radix Adenophorae (Radix Glehniae) 16.8-20.8, Radix Platycodonis 16.7-20.7

3, the electuary of alleviation SARS symptom according to claim 1 and 2, wherein the weight proportion of each raw material is:

Folium Perillae 15, Herba Menthae 12.5, Herba Moslae 10, Rhizoma Polygonati Odorati 25, Radix Adenophorae (Radix Glehniae) 18.8, Radix Platycodonis 18.7

4, the preparation method of the electuary of claim 1 or 2 or 3 described alleviation SARS symptoms is characterized in that being made up of the following step:

A1), Folium Perillae, Herba Menthae, Herba Moslae are ground into 80 orders, raw material is packed into reinstall supercritical CO behind the cloth bag ₂Covered and enclosed in the extraction axe;

2), with CO ₂Pour in the axe, pressurization 1.0-1.3mpa, temperature 36-37 ℃, open rectifying column, extract the volatile oil of extraction behind the 3-3.5h;

B1), the raw material slag after will extracting puts into the hot reflux axe, separate, centrifugal filtration, after concentrating active ingredient;

2), the active ingredient after will concentrating is put into drying equipment and is carried out spray drying;

C is crushed to 2000 orders with Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Platycodonis with super micron mill;

D is with the active ingredient that obtains in the B step and the ultra-micro powder mixed pelletization in the C step;

E is sprayed onto the volatile oil that extracts in the A step in the granule that obtains in B, the C step again, in the packaging bag of again finished product being packed into.