CN120605051A - Lung cancer tumor sampling device and method - Google Patents
Lung cancer tumor sampling device and methodInfo
- Publication number
- CN120605051A CN120605051A CN202510789345.8A CN202510789345A CN120605051A CN 120605051 A CN120605051 A CN 120605051A CN 202510789345 A CN202510789345 A CN 202510789345A CN 120605051 A CN120605051 A CN 120605051A
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- sampling
- needle
- needle core
- push plate
- housing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
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- Life Sciences & Earth Sciences (AREA)
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- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to the technical field of medical equipment, in particular to a lung cancer tumor sampling device and method, comprising a needle core and a sleeve which is coaxially and slidably matched with the needle core, wherein a plurality of needle cores and sleeves are arranged, the plurality of needle cores are in one-to-one correspondence with the plurality of sleeves, and the plurality of needle cores are parallel; one end of the plurality of the sleeve pipes, which is back to the sampling groove, is connected with a shell in a hollow structure together, a push plate is connected in the shell in a sliding manner along the needle shaft, and one end of the plurality of the needle shafts, which is back to the sampling groove, penetrates through the shell and is inserted into the shell to be connected with the push plate; an adjusting part for driving the push plate to slide in the shell is arranged between the shell and the push plate. The method solves the problem that in the prior art, a single-point sampling may miss a key mutation area, so that false negative is caused.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a lung cancer tumor sampling device and method.
Background
Lung cancer is a malignant tumor with highest morbidity and mortality worldwide, and its pathological types are mainly classified into non-small cell lung cancer (NSCLC) and Small Cell Lung Cancer (SCLC). Because lung cancer has obvious spatial heterogeneity characteristics, different areas of the same tumor focus may have differential expression of EGFR, ALK, KRAS and other driving genes, and the heterogeneity of the molecular level directly influences the selection of clinical treatment schemes and the evaluation of treatment effects. Thus, obtaining a representative tumor tissue sample is of decisive importance for achieving accurate pathological diagnosis and personalized treatment.
At present, the common lung cancer sampling technology mainly comprises percutaneous lung puncture biopsy, bronchoscope biopsy, in-vitro sampling after surgical excision and the like. Among them, percutaneous pulmonary aspiration biopsy is an important diagnostic means, and its operational procedure is as follows:
Firstly, determining the tumor position and planning a puncture path through CT or ultrasonic image guidance;
Subsequently, a single-core biopsy needle (such as a Tru-Cut needle) is inserted into the target area along a predetermined path;
In the tissue capturing stage, an operator needs to push the needle core out of the sleeve to expose the sample groove, push the sleeve forward and retract the needle core at the same time, and cut and acquire a tissue strip in a mechanical extrusion mode (the relative movement of the sleeve and the needle core generates a scissor-like closing effect);
extracting the puncture needle after sampling is completed, and carrying out pathological analysis on the obtained tissue strips;
when the sample size is insufficient, it is generally necessary to repeat the puncturing operation 3 to 5 times.
However, a single puncture can only obtain a single point sample, multiple punctures are required to cover tumor heterogeneity, the operating time is prolonged, and single point sampling may miss critical mutation areas (e.g., only necrotic tissue is taken), resulting in false negatives.
Disclosure of Invention
Accordingly, the present invention is directed to a lung cancer tumor sampling device and method, which solves the problem that in the prior art, a single point sampling may miss a critical mutation area, resulting in false negative.
The invention is realized by the following technical scheme:
the lung cancer tumor sampling device comprises a needle core and a sleeve which is coaxially and slidably matched with the needle core, wherein a plurality of needle cores and sleeves are arranged, the needle cores are in one-to-one correspondence with the sleeves, and the needle cores are parallel;
One end of the plurality of the sleeve pipes, which is back to the sampling groove, is connected with a shell in a hollow structure together, a push plate is connected in the shell in a sliding manner along the needle shaft, and one end of the plurality of the needle shafts, which is back to the sampling groove, penetrates through the shell and is inserted into the shell to be connected with the push plate;
An adjusting part for driving the push plate to slide in the shell is arranged between the shell and the push plate.
Further, the plurality of sleeves are arranged in a linear array, the arrangement direction is perpendicular to the axis of the sleeves, and the plurality of sleeves are equally divided into two symmetrical acquisition parts;
Two connecting strips corresponding to the two collecting parts one by one are arranged in the shell, and a plurality of sleeves in the collecting parts are detachably and fixedly connected with the corresponding connecting strips;
The two connecting strips are rotationally connected with the inner wall of one end of the shell facing the sampling groove, and the rotation center line is parallel to the needle core;
the needle core is in sliding connection with the baffle, and the sliding track is overlapped with the rotating track of the corresponding sleeve.
Further, a plurality of jacks corresponding to the plurality of sleeves one by one are formed in the connecting strip, and one end of each sleeve, which is opposite to the sampling groove, is inserted into the corresponding jack.
Further, one end of the connecting strip is provided with two coaxial arc-shaped sliding holes, and the axes of the arc-shaped sliding holes are coplanar with the axes of the plurality of needle cores in the corresponding collecting part;
Two sections of the arc sliding holes are internally provided with sliding rods, one ends of the sliding rods extend along the axial direction of the needle shaft and are fixedly connected with the end wall of the shell, and the outer circular surfaces of the sliding rods are attached to two radial side walls of the arc sliding holes.
Further, the two opposite ends of the two connecting strips are fixedly connected with outer gear rings, the axis of the outer gear rings is overlapped with the rotation center line of the corresponding connecting strip, and the two outer gear rings are meshed;
and a limiting part for limiting the rotation of the outer gear ring is arranged between the outer gear ring and the shell.
Further, the limiting part comprises a limiting block embedded into the top wall of the shell, a first bulge matched with the tooth socket of the outer gear is arranged on one side surface of the limiting block facing the outer gear, and the first bulge is inserted into the tooth socket of the outer gear;
The limiting block is in radial sliding fit with the top wall of the shell along the outer gear ring, a second bulge is fixedly connected to one side surface of the limiting block, which is back to the outer gear ring, and the second bulge protrudes out of the outer top surface of the shell when the first bulge is embedded into a tooth slot of the outer gear ring.
Further, one end of the shell, which is back to the sampling groove, is provided with a handle with an opening at one end, the opening end of the handle is detachably and fixedly connected with the shell, and the interior of the handle is communicated with the interior of the shell;
The adjusting part comprises a compression spring arranged in the shell, a rack parallel to the needle core and a gear meshed with the rack, one end of the compression spring is propped against the end wall of the shell facing the sampling groove, the other end of the compression spring is propped against the push plate, and the sampling groove on the needle core is retracted into the sleeve to be covered and blocked in a natural extension state of the compression spring;
One end of the rack is fixedly connected with the push plate, the other end is inserted into the handle the inner wall of the grip is in sliding fit;
The two ends of the gear are respectively inserted into the two side walls of the grip and are in running fit, a deflector rod is arranged on one side of the gear, which is opposite to the rack, one end of the deflector rod is fixedly connected with the outer circular surface of the gear, and the other end of the deflector rod radially penetrates through the side walls of the grip along the gear and extends out of the grip.
Further, the gear is provided with a lower part of the rack, a limit groove is formed in the top surface of the rack, a rotating bar is arranged above the rack, the middle part of the rotating bar is rotationally connected with the inner wall of the handle, and the rotating center line is parallel to the rotating center line of the gear;
The bottom end of the rotating strip extends downwards obliquely towards the direction of the sampling groove and is propped against the top surface of the rack, the top end of the rotating strip penetrates through the top wall of the handle and extends out of the handle, and an included angle between the rotating strip and the rack is an acute angle when the bottom end of the rotating strip is inserted into the limiting groove.
A lung cancer tumor sampling method comprises the following steps by using the device:
s1, preoperative positioning, namely determining the tumor position and the puncture path through imaging examination;
S2, array puncture, namely synchronously puncturing a plurality of needle cores into tumor tissues, wherein each needle core sampling groove is positioned in different areas of the tumor;
S3, step-by-step sampling:
S31, pushing the push plate through the adjusting part to enable the needle core to move forwards, and moving each needle core sampling groove out of the corresponding sleeve to be exposed;
s32, keeping the position of the sleeve fixed, pulling the needle core back through the push plate, anchoring tumor tissues by utilizing barbs on the front edge of the sampling groove, shearing the tumor tissues in cooperation with the front end of the sleeve, and storing the sheared tumor tissues in the sampling groove;
s4, sample recovery, namely pulling out the whole needle core and the sleeve, pushing the push plate again through the adjusting part to enable the needle core to move forwards, exposing the sampling grooves on each needle core, taking out samples in the sampling grooves, and numbering and recording;
S5, carrying out heterogeneity analysis, namely respectively carrying out molecular detection on samples obtained by each needle core.
Further, the step S2 specifically includes:
s21, rotating the two connecting strips to adjust the relative positions and fixing, for example, the two connecting strips are collinear/parallel/the extension lines intersect, and the corresponding plurality of needle cores are arranged in a straight line/in a matrix/in a radial manner;
S22, synchronously penetrating a plurality of needle cores into tumor tissues, wherein each needle core sampling groove is positioned in different areas of the tumor.
The invention has the beneficial effects that:
According to the lung cancer tumor sampling device and method, the plurality of sleeves are arranged on the shell, the plurality of needle cores corresponding to the plurality of sleeves are arranged on the push plate, the push plate is driven to slide on the shell by the adjusting part, synchronous movement of the plurality of needle cores on the corresponding sleeves is realized, meanwhile, the plurality of positions of tumor tissues are sampled, and the risk of false negative caused by deviation of sampling points from key mutation areas is reduced.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objects and other advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out in the specification.
Drawings
FIG. 1 is a schematic perspective view of an embodiment of the present invention (state one);
FIG. 2 is a schematic perspective view (state two) of an embodiment of the present invention;
fig. 3 is a schematic perspective view of an embodiment of the present invention (state three);
FIG. 4 is an exploded view of an embodiment of the present invention;
FIG. 5 is a top view of an embodiment of the present invention;
FIG. 6 is a cross-sectional view of A-A of FIG. 5;
FIG. 7 is an enlarged view at C in FIG. 6;
FIG. 8 is a cross-sectional view of B-B of FIG. 5;
FIG. 9 is a schematic perspective view of a housing according to an embodiment of the present invention;
FIG. 10 is a schematic perspective view of a rotating bar according to an embodiment of the present invention;
FIG. 11 is a schematic perspective view of a stopper according to an embodiment of the present invention;
FIG. 12 is a schematic perspective view of a sleeve according to an embodiment of the present invention;
FIG. 13 is a schematic view showing a three-dimensional structure of a push plate and a core pin according to an embodiment of the present invention;
FIG. 14 is a schematic perspective view of a needle according to an embodiment of the present invention;
FIG. 15 is a schematic perspective view of a grip according to an embodiment of the present invention.
1, A needle core, 11, a sampling groove, 2, a sleeve, 3, a shell, 31, a connecting bar, 311, an inserting hole, 312, an arc sliding hole, 313, a sliding bar, 32, an outer tooth ring, 33, a limiting block, 331, a first protrusion, 332, a second protrusion, 4, a push plate, 41, a guide hole, 42, a sliding block, 421, a threaded hole, 5, a handle, 51, a cover plate, 61, a compression spring, 62, a rack, 621, a limiting groove, 63, a gear, 64, a deflector rod, 65 and a rotating bar.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the foregoing description of the invention, it should be noted that the azimuth or positional relationship indicated by the terms "one side", "the other side", etc. are based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship in which the inventive product is conventionally put in use, are merely for convenience of describing the invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and therefore should not be construed as limiting the invention. Furthermore, the terms "first," "second," and the like, are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
Furthermore, the terms "identical" and the like do not denote that the components are identical, but rather that there may be minor differences. The term "perpendicular" merely means that the positional relationship between the components is more perpendicular than "parallel" and does not mean that the structure must be perfectly perpendicular, but may be slightly tilted.
Referring to fig. 1-15, the invention provides a technical scheme that the lung cancer tumor sampling device comprises a needle core 1 and a sleeve 2 which is coaxially and slidably matched with the needle core 1, wherein a plurality of needle cores 1 and the sleeve 2 are respectively arranged, the needle cores 1 are in one-to-one correspondence with the sleeve 2, and the needle cores 1 are parallel;
One end of the plurality of sleeves 2, which is opposite to the sampling groove 11, is commonly connected with a hollow shell 3, a push plate 4 is axially and slidably connected in the shell 3 along the needle core 1, and one end of the plurality of needle cores 1, which is opposite to the sampling groove 11, penetrates through the shell 3 and is inserted into the shell 3 to be connected with the push plate 4;
an adjusting part for driving the push plate 4 to slide in the shell 3 is arranged between the shell 3 and the push plate 4.
In this scheme, through set up a plurality of sleeve pipes 2 on casing 3 to set up a plurality of needle cores 1 corresponding with a plurality of sleeve pipes 2 on push pedal 4, utilize adjusting part to order about push pedal 4 to slide on casing 3, realize a plurality of needle cores 1 and go up synchronous motion in corresponding sleeve pipe 2, sample a plurality of positions of tumour tissue simultaneously. Compared with the traditional single-needle sampling device, the device pushes the plurality of needle cores 1 to synchronously move through the push plate 4 to sample, simultaneously samples a plurality of points, enlarges the sampling coverage area, and obviously reduces the risk of false negative caused by the deviation of the sampling points from a key mutation area.
The needle core 1 and the push plate 4 can be fixedly connected together in a mode of selective bonding, threaded connection and the like, the sleeve 2 and the shell 3 can be fixedly connected together in a mode of selective bonding, threaded connection and the like, the shell 3 is semi-elliptic cylindrical in shape, the push plate 4 is semi-elliptic plate-shaped and is matched with the inside of the shell 3, after the push plate 4 is embedded into the shell 3, the outer contour of the push plate 4 is attached to the inner wall of the shell 3, the push plate 4 has a structural thickness, the push plate 4 can be prevented from tilting and overturning, and the push plate 4 can only slide along the axial direction of the needle core 1 in a single degree of freedom in the shell 3, so that the device has a compact overall structure and high structural stability, and is shown in figures 9 and 13.
The front end (the end inserted into the tumor tissue) of the needle core 1 is sharp and plays a role in guiding the auxiliary needle core 1 to be inserted into the tumor tissue. The outer circular surface of the front end of the needle core 1 is provided with a sampling groove 11 for storing sheared and separated tumor tissues, and the edge of the front end of the sampling groove 11 is provided with a sharper cone-shaped barb which is used for anchoring the tumor tissues in the process of retracting the needle core 1 into the sleeve 2 and shearing the tumor tissues under the co-extrusion action of the edge of the front end of the sleeve 2 as shown in figure 14. The principle of shearing tumor tissue by the relative movement of the needle 1 and the cannula 2 is well established and will not be described in detail herein.
In addition, the adjusting part may be provided as a motor and a screw. The motor fixed mounting is outside the one end of casing 3 dorsad sampling groove 11, passes through shaft coupling etc. with screw rod one end and motor output transmission connection, and the screw rod other end runs through casing 3 end wall and push pedal 4 in proper order along the axial extension of nook closing member 1, makes screw rod and casing 3 normal running fit, and screw rod and push pedal 4 pass through screw thread fit connection, under the condition that restriction screw rod moved along the axial, only need start the motor, can drive nook closing member 1 and corresponding sleeve pipe 2 through the screw rod and take place relative motion, take a sample the work.
When in use, the specific steps are as follows:
preoperative positioning (imaging guidance) by determining tumor position, size and optimal puncture path by imaging means such as CT, ultrasound or MRI, avoiding important blood vessels and organs;
checking and sterilizing the device, namely checking that the internal structure of the device is stable, the operation is smooth (such as a motor screw mechanism), and the device is sterilized, so that the risk of infection is avoided;
Penetration needle (array penetration) by synchronously penetrating multiple cannulas 2 into tumor tissue along a predetermined penetration path so that sampling slots 11 of each needle core 1 are distributed in different regions (such as edges, centers, junctions) of the tumor;
Step sampling (tissue shearing) by starting an adjusting part (such as a motor driving screw rod rotates forwards), pushing a push plate 4 to enable the needle cores 1 to move forwards, enabling sampling grooves 11 of the needle cores 1 to extend out of a sleeve 2 and be exposed in tumor tissues, then keeping the sleeve 2 fixed, pulling the push plate 4 backwards (such as the motor driving screw rod rotates reversely), hooking the tissues by barbs at the front ends of the sampling grooves 11, shearing tumor samples under the extrusion action of the front ends of the sleeve 2, and keeping the samples in the sampling grooves 11 until the sampling grooves 11 are completely covered and plugged by the sleeve 2;
the method comprises the steps of sample recovery and marking, namely, integrally pulling out the needle core 1 and the sleeve 2 from the body, pushing the push plate 4 again, enabling the needle core 1 to move forward to expose the sampling groove 11, taking out tissue samples in the grooves by using forceps or special tools, marking the samples according to the spatial arrangement positions (such as from left to right, from outside to inside and the like corresponding to the numbers 1-N) of the needle core 1, and recording the anatomical positions of the samples;
heterogeneity analysis the tissue of each sampling site was examined for pathology or molecular detection (e.g., gene mutation, PD-L1 expression), respectively, to assess heterogeneity within the tumor.
In the embodiment, a plurality of the sleeves 2 are arranged in a linear array, the arrangement direction is perpendicular to the axis of the sleeves 2, and the sleeves 2 are uniformly divided into two symmetrical acquisition parts;
Two connecting strips 31 corresponding to the two collecting parts one by one are arranged in the shell 3, and a plurality of sleeves 2 in the collecting parts are detachably and fixedly connected with the corresponding connecting strips 31;
The two connecting strips 31 are both rotationally connected with the inner wall of one end of the shell 3 facing the sampling groove 11, and the rotation center line is parallel to the needle core 1;
the needle core 1 is in sliding connection with the baffle, and the sliding track is coincident with the rotating track of the corresponding sleeve 2.
In the scheme, the plurality of sleeves 2 are designed into two symmetrical acquisition parts, and the rotatable connecting strips 31 are adopted for flexible adjustment, so that the arrangement rule of the plurality of sleeves 2 can be adjusted and changed, and the sampling layout is adjusted. The two acquisition parts can be independently adjusted in angle (0-90 degrees, for example), so that the arrangement modes of the sleeve 2 are diversified, and the three following use states can be presented:
In the first state (shown in figure 1), the plurality of sleeves 2 are arranged in a straight line (the two connecting bars 31 are collinear) and are suitable for linear sampling of long-strip tumors;
a second state (shown in figure 2) in which the plurality of sleeves 2 are arranged in a V shape or in a radial shape (the extension lines of the two connecting strips 31 intersect) and are suitable for multi-region coverage of the dispersive tumor;
And in the third state (shown in figure 3), the plurality of sleeves 2 are arranged in a matrix (two connecting strips 31 are parallel), so that the cross section of the tumor can be subjected to grid partition sampling, and the method is particularly suitable for tumors with larger volumes (more than 3 cm) or obvious heterogeneity, and the risk of missed detection is obviously reduced.
In addition, the rear end (the end facing away from the sampling groove 11) of the sleeve 2 can be inserted into the connecting strip 31 and connected through screw thread fit, so that the detachable purpose is achieved, and the sleeve 2 can be detached and installed according to the actual use requirement, so that the sleeve 2 can be sterilized and disinfected. And, a plurality of avoidance holes corresponding to the plurality of sleeves 2 one by one are formed on the end wall of the shell 3 facing the sampling groove 11, and the sleeves 2 are inserted into the corresponding avoidance holes and can normally rotate, as shown in fig. 2.
In this embodiment, the connection strip 31 is provided with a plurality of jacks 311 corresponding to the plurality of sleeves 2 one by one, and one end of the sleeve 2 opposite to the sampling slot 11 is inserted into the jack 311.
In this scheme, jack 311 can be designed into comparatively smooth column hole, as shown in fig. 9, through inserting sleeve pipe 2 tight fit in jack 311, reaches fixed mounting sleeve pipe 2's purpose, easy operation is convenient. Or is designed into a round hole shape, and is provided with internal threads on the inner circular surface, and the rear end of the sleeve 2 is inserted into the jack 311 and is connected through thread fit, so that the purpose of fixedly installing the sleeve 2 is achieved. In this case, a tight-fitting manner is preferred.
The baffle is provided with guide holes 41 corresponding to the needle cores 1 in the collecting part one by one, a sliding block 42 is slidably matched in the guide holes 41, and the sliding track of the sliding block 42 is overlapped with the rotating track of the corresponding sleeve 2 (the needle core 1). In the case that the needle core 1 is connected with the corresponding slider 42, the connecting bar 31 can normally drive the needle core 1 to move, and the layout of the needle core 1 is changed, as shown in fig. 13.
In addition, the threaded hole 421 can be formed in the slider 42, and the external thread is formed on the outer circumferential surface of the rear end (the end facing away from the sampling groove 11) of the needle core 1, and the rear end of the needle core 1 is inserted into the threaded hole 421 to achieve the purpose of disassembly by using threaded fit connection, so that the sleeve 2 and the needle core 1 can be disassembled and removed from the device, thereby facilitating maintenance and replacement, or the number of the sleeve 2 and the needle core 1 can be increased or decreased according to actual use conditions, and the number and the distance between sampling points can be changed. Meanwhile, the sleeve 2 and the needle core 1 can be used as disposable products, the risk of cross infection caused by incomplete sterilization is reduced, the rest parts such as the shell 3 are not contacted with the skin of a patient, and the risk of cross infection is low, so that the disposable sterile needle can be recycled after sterilization, and the use cost is reduced.
In this embodiment, two coaxial arc-shaped sliding holes 312 are provided at one end of the connecting strip 31, and the axes of the arc-shaped sliding holes 312 are coplanar with the axes of the plurality of needle cores 1 in the corresponding collecting part;
the two sections of the arc slide holes 312 are respectively provided with a slide bar 313, one end of each slide bar 313 extends along the axial direction of the needle core 1 and is fixedly connected with the end wall of the shell 3, and the outer circular surface of each slide bar 313 is attached to the two radial side walls of the arc slide hole 312.
In this embodiment, the outer circumferential surface of the sliding rod 313 is attached to two radial side walls of the arc sliding hole 312, and two sliding rods 313 are provided, so that the sliding rod 313 can only slide along the length direction of the arc sliding hole 312, and the connecting strip 31 can only rotate with the axial direction of the arc sliding hole 312 as the center, as shown in fig. 9 and 10. The free end of the sliding rod 313 extends out of the arc-shaped sliding hole 312 through the arc-shaped sliding hole 312, and the end of the sliding rod can limit the axial movement of the connecting strip 31 along the sliding rod 313 by means of a plug-in bolt, a threaded fit connecting nut and the like. The purpose of rotationally connecting the connecting strip 31 with the housing 3 is achieved.
In this embodiment, two opposite ends of the two connection bars 31 are fixedly connected with an outer ring gear 32, the axis of the outer ring gear 32 overlaps with the rotation center line of the corresponding connection bar 31, and the two outer ring gears 32 are meshed;
A limiting part for limiting the rotation of the outer gear ring 32 is arranged between the outer gear ring 32 and the shell 3.
In this scheme, as shown in fig. 4, two connecting bars 31 are connected and driven by two external gear rings 32, when one connecting bar 31 rotates, the other connecting bar 31 rotates in the opposite direction, and when the sampling layout needs to be adjusted, the constraint of the limiting part on the connecting bars is released, and the symmetrical angle adjustment is realized by the meshing and driving of the external gear rings, so as to improve the adjustment efficiency. And the two outer gear rings 32 are mutually supported and limited, so that the structural stability of the device is further improved.
In the embodiment, the limiting part comprises a limiting block 33 embedded in the top wall of the shell 3, a first protrusion 331 matched with a tooth socket of the outer gear ring 32 is arranged on one side surface of the limiting block 33 facing the outer gear ring 32, and the first protrusion 331 is inserted into the tooth socket of the outer gear ring 32;
The limiting block 33 is in sliding fit with the top wall of the shell 3 along the radial direction of the outer gear ring 32, a second protrusion 332 is fixedly connected to one side surface of the limiting block 33, which is back to the outer gear ring 32, and the second protrusion 332 protrudes out of the outer top surface of the shell 3 when the first protrusion 331 is embedded into the tooth slot of the outer gear ring 32.
In this scheme, the cavity that is used for accomodating slider 42 has been seted up to roof in the casing 3, and stopper 33 embedding cavity is in and close-fitting connection (interference fit), under no external force extrusion, utilizes frictional force can restrict stopper 33 in the cavity slip (along outer ring gear 32 radial slip).
When the external gear ring connecting device is used, when the positions of the two connecting strips 31 need to be fixed, the second protrusion 332 is only required to be pressed outside the shell 3, so that the limiting block 33 slides to be close to the external gear ring 32, the first protrusion 331 is inserted into the tooth slot of the external gear ring 32 to form a meshing state, and the limiting block 33 is limited to move along the circumferential tangential direction of the external gear ring 32 due to the interference effect of the side wall of the concave cavity, so that the limiting block 33 and the external gear ring 32 form a clamping state, and further the rotation of the connecting strips 31 is limited.
When the relative positions of the two connecting bars 31 need to be adjusted, only the second protrusion 332 needs to be held and pulled out of the housing 3, so that the limiting block 33 slides away from the outer gear ring 32, and after the first protrusion 331 moves out of the tooth slot, the clamping state is eliminated, and the connecting bars 31 can rotate normally, as shown in fig. 8 and 11.
In the embodiment, one end of the shell 3, which is opposite to the sampling groove 11, is provided with a handle 5 with an opening at one end and a hollow structure, the opening end of the handle 5 is detachably and fixedly connected with the shell 3, and the interior of the handle 5 is communicated with the interior of the shell 3;
The adjusting part comprises a compression spring 61 arranged in the shell 3, a rack 62 parallel to the needle core 1 and a gear 63 meshed with the rack 62, one end of the compression spring 61 is propped against the end wall of the shell 3 facing the sampling groove 11, the other end is propped against the push plate 4, and the sampling groove 11 on the needle core 1 is retracted into the sleeve 2 to be covered and blocked when the compression spring 61 is in a natural extension state;
one end of the rack 62 is fixedly connected with the push plate 4, and the other end of the rack is inserted into the grip 5 and is in sliding fit with the inner wall of the grip 5;
The two ends of the gear 63 are respectively inserted into the two side walls of the grip 5 and are in running fit, a deflector rod 64 is arranged on one side of the gear 63, which is opposite to the rack 62, one end of the deflector rod 64 is fixedly connected with the outer circular surface of the gear 63, and the other end of the deflector rod extends out of the grip 5 along the radial direction of the gear 63, penetrating through the side walls of the grip 5.
In this scheme, as shown in fig. 6 and 15, one end of the casing 3 facing away from the sampling groove 11 is opened, the open end of the handle 5 is provided with a cover plate 51 for covering the opening of the plugging casing 3, and the cover plate 51 and the casing 3 are fixed by bolt lock so as to facilitate radial disinfection and maintenance of each part inside the casing 3. The handle 5 is arranged at one end of the shell 3, which is opposite to the sampling groove 11, and the limiting block 33 is arranged on the side wall of the shell 3, so that the handle 5 and the deflector 64 are far away from the limiting block 33, and the position of the limiting block 33 is prevented from being changed by touching the limiting block 33 by mistake.
The compression spring 61 elastically supports the push plate 4. The handle 5 is provided with a position avoiding notch on the shift lever 64, which is communicated with the inner side and the outer side of the handle 5.
When the hand-held handle is used, a relevant technician grasps the hand-held handle by hand, uses an index finger to hook the deflector rod 64 at one end outside the handle 5, forcefully fluctuates the deflector rod 64 to drive the gear 63 to drive, pushes the push plate 4 and the needle core 1 to move forwards through the gear rack 62, exposes the sampling groove 11, compresses the spring 61 to be extruded and contracted for energy storage, and when the finger slides off from the deflector rod 64, the resistance to the deflector rod 64 disappears, the spring releases energy to rebound rapidly, and the push plate 4 is driven to move after driving the needle core 1 to cut tumor tissues.
In this embodiment, the gear 63 is disposed below the rack 62, a limit groove 621 is formed on the top surface of the rack 62, a rotating bar 65 is disposed above the rack 62, the middle of the rotating bar 65 is rotationally connected with the inner wall of the grip 5, and the rotation center line is parallel to the rotation center line of the gear 63;
the bottom end of the rotating bar 65 extends obliquely downwards towards the direction of the sampling groove 11 and abuts against the top surface of the rack 62, the top end of the rotating bar penetrates through the top wall of the handle 5 and extends out of the handle 5, and when the bottom end of the rotating bar 65 is inserted into the limiting groove 621, the included angle between the rotating bar 65 and the rack 62 is an acute angle.
In this scheme, as shown in fig. 7, the limiting grooves 621 are provided with a plurality of limiting grooves 621, and the plurality of limiting grooves 621 are uniformly distributed along the length direction of the rack 62, and the weight from the top end of the rotating bar 65 to the section of the rotating center line is less than the weight from the bottom end of the rotating bar 65 to the section of the rotating center line, so that the bottom end of the rotating bar 65 naturally sags, and is always in an abutting state with the rack 62.
When the bottom end of the rotating bar 65 is inserted into the limiting groove 621, the distance from the rotating center line of the rotating bar 65 to the top surface of the rack 62 is smaller than the length from the top end of the rotating bar 65 to the rotating center line, two sliding grooves are formed in the opening end of the handle 5, two side walls in the middle of the rack 62 are respectively embedded into the two sliding grooves and are in sliding fit, and one end of the rack 62 is fixedly connected with the push plate 4. Therefore, when the bottom end of the rotating bar 65 is inserted into the limiting groove 621, the rotating bar 65 and the limiting groove 621 are in a clamped state, and the limiting rack 62 slides away from the sleeve 2 (limiting the rearward movement of the needle core 1), so that the spring maintains an energy storage state.
When the thumb of the related technician presses the top end of the rotating bar 65, the rotating bottom end of the rotating bar 65 is lifted up until sliding out from the limiting groove 621, the clamping state is eliminated, and under the elastic force of the compression spring 61, the push plate 4 drives the rack 62 and the needle core 1 to move backwards together, so that the shearing work is automatically performed.
A lung cancer tumor sampling method comprises the following steps by using the device:
s1, preoperative positioning, namely determining the tumor position and the puncture path through imaging examination;
s2, array puncture, namely synchronously puncturing a plurality of needle cores 1 into tumor tissues, wherein sampling grooves 11 of the needle cores 1 are positioned in different areas of the tumor;
S3, step-by-step sampling:
S31, pushing the push plate 4 through the adjusting part to enable the needle core 1 to move forwards, and moving the sampling grooves 11 of the needle cores 1 out of the corresponding sleeve 2 for exposure;
S32, keeping the position of the sleeve 2 fixed, pulling back the needle core 1 through the push plate 4, anchoring tumor tissues by barbs on the front edge of the sampling groove 11, shearing the tumor tissues in cooperation with the front end of the sleeve 2, and storing the sheared tumor tissues in the sampling groove 11;
s4, sample recovery, namely pulling out the needle core 1 and the sleeve 2 integrally, pushing the push plate 4 again through the adjusting part to enable the needle core 1 to move forwards, exposing the sampling grooves 11 on each needle core 1, taking out samples in the sampling grooves 11, and numbering and recording;
s5, carrying out heterogeneity analysis, namely respectively carrying out molecular detection on the samples obtained by each needle core 1.
In this embodiment, the step S2 specifically includes:
S21, rotating the two connecting strips 31 to adjust the relative positions and fixing, for example, the two connecting strips 31 are collinear/parallel/the extension lines intersect, and the corresponding plurality of needle cores 1 are arranged in a straight line/in a matrix/in a radial shape;
s22, synchronously penetrating a plurality of needle cores 1 into tumor tissues, wherein the sampling grooves 11 of the needle cores 1 are positioned in different areas of the tumor.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention.
Claims (10)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510789345.8A CN120605051A (en) | 2025-06-13 | 2025-06-13 | Lung cancer tumor sampling device and method |
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| CN202510789345.8A CN120605051A (en) | 2025-06-13 | 2025-06-13 | Lung cancer tumor sampling device and method |
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| CN120605051A true CN120605051A (en) | 2025-09-09 |
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| CN202510789345.8A Pending CN120605051A (en) | 2025-06-13 | 2025-06-13 | Lung cancer tumor sampling device and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120899305A (en) * | 2025-10-10 | 2025-11-07 | 湖南德缘泓医疗科技有限公司 | Puncture sampling device for tumor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120899305A (en) * | 2025-10-10 | 2025-11-07 | 湖南德缘泓医疗科技有限公司 | Puncture sampling device for tumor |
| CN120899305B (en) * | 2025-10-10 | 2026-02-03 | 湖南德缘泓医疗科技有限公司 | Puncture sampling device for tumor |
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