CN120570632A - A digestive tract liquid biopsy sampling device for internal medicine - Google Patents
A digestive tract liquid biopsy sampling device for internal medicineInfo
- Publication number
- CN120570632A CN120570632A CN202510457167.9A CN202510457167A CN120570632A CN 120570632 A CN120570632 A CN 120570632A CN 202510457167 A CN202510457167 A CN 202510457167A CN 120570632 A CN120570632 A CN 120570632A
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- detection
- cavity
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- internal medicine
- sampling device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endoscopes (AREA)
Abstract
The invention discloses an alimentary canal liquid biopsy sampling device for internal medicine, which comprises an inner detection part and an outer detection part, wherein the inner detection part comprises a detection sphere and a spherical shell, the diameter of the detection sphere is smaller than that of the spherical shell and is arranged in the inner cavity of the spherical shell, the spherical shell is hollow, a magnet part is arranged at one end in the detection sphere, a sampling part and a camera part are also arranged on the detection sphere, the outer detection part comprises a main body frame, an annular moving part capable of sliding back and forth is arranged on the main body frame, and an electromagnet capable of moving along the inner side wall of the annular moving part is arranged at the inner side of the annular moving part. The inner detection part of the invention adopts the detection sphere with built-in magnetic control, and is sleeved with the hollow sphere shell, so that isotropy and steering are flexible, the hollow sphere shell rolls and advances during movement to reduce friction force, and the hollow sphere shell is easy to roll in intestinal folds, thereby effectively improving rolling speed and effectively improving magnetic field driving efficiency.
Description
Technical Field
The invention relates to a digestive tract liquid biopsy sampling device for internal medicine, and belongs to the technical field of medical equipment.
Background
The digestive tract is a long muscular tract extending from the mouth to the pharynx, esophagus, stomach, small intestine, large intestine, ending in the anal canal, and includes the mouth, pharynx, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, appendix, colon, rectum), and anal canal. When the digestive tract is diseased, in order to determine the specific position and condition of the disease, the digestive tract needs to be observed and sampled, and the gastrointestinal mirror is adopted for observation at present, and the patients may have nausea, vomiting, choking, dyspnea, chest distress, breath holding, abdominal distention and the like in the examination process, and the feeling of pharyngeal mucosa injury, pharyngeal discomfort, abdominal pain and abdominal distention may be caused after the examination.
The digestive tract liquid biopsy sampling device is mainly used for acquiring liquid samples (such as gastric juice, intestinal juice, blood, exosomes, circulating tumor DNA and the like) in the digestive tract in a minimally invasive or noninvasive mode so as to assist in early diagnosis and monitoring of diseases (such as cancers and inflammations). In recent years, the capsule type sampling device is used as a noninvasive painless diagnosis and treatment tool in the gastrointestinal tract of a human body, and can effectively improve the examination comfort and the tolerance of a patient. Existing capsule sampling devices rely on digestive tract peristalsis and may not accurately release and adsorb materials in a target area (e.g., a particular segment of the intestine). And the sample recovery is delayed, the capsule needs to be naturally discharged, the sample degradation such as DNA fracture and protein inactivation can be caused, and part of patients can be detained by the capsule and need to be taken out by an endoscope.
In the prior art, the swallow part of the digestive tract liquid biopsy sampling device mostly adopts a capsule shape, such as an invention patent, namely a digestive tract sampling capsule (CN 109497917B), although the capsule shape can imitate a tablet shape (ellipse/cylinder) and accords with the swallowing habit of human beings. However, the steering flexibility of the long axis is limited, and the smooth cylindrical surface is easy to generate laminar flow resistance in the digestive tract mucus environment and generates friction with the inner wall of the human digestive tract, so that the magnetic field driving efficiency is reduced, and the movement speed is reduced. Therefore, we propose a medical digestive tract liquid biopsy sampling device to solve the above problems.
Disclosure of Invention
The invention aims to provide a digestive tract liquid biopsy sampling device for internal medicine, wherein a swallowing part of the digestive tract liquid biopsy sampling device adopts a spherical structure, a hollowed-out sphere shell is sleeved outside the digestive tract liquid biopsy sampling device, isotropy and steering are flexible, and the hollowed-out sphere shell rolls during movement to reduce friction force and is easy to roll in intestinal folds, so that the rolling speed is improved.
The digestive tract liquid biopsy sampling device for the internal medicine comprises an inner detection part and an outer detection part, wherein the inner detection part comprises a detection sphere and a spherical shell, the diameter of the detection sphere is smaller than that of the spherical shell, the detection sphere is arranged in an inner cavity of the spherical shell, the spherical shell is hollow, the inner wall and the outer wall are smooth, one end in the detection sphere is provided with a magnet part, the magnet part adopts a permanent magnet, the detection sphere is internally provided with a magnet part formed by a high magnetic energy product permanent magnet, the magnet part can interact with an external magnetic field to generate a motion driving force, the detection sphere is also provided with a sampling part and a camera part, the sampling part is used for absorbing digestive tract liquid, the sampling part can be symmetrically provided with two parts, the two parts can be respectively sampled at one time, the camera part adopts a 360-degree micro lens, the camera part can be provided with illumination equipment to carry out panoramic observation, the outer equipment comprises a main body frame, the main body frame is provided with an annular moving part capable of sliding forwards and backwards, the inner side of the annular moving part is provided with an electromagnet capable of moving along the inner side wall of the annular moving part, the electromagnet is used for generating a controllable magnetic field, the electromagnet is used for generating a motion driving force through the interaction between the detection sphere and the inner magnetic field, the detection sphere and the detection sphere generates a motion magnetic field, the motion gradient magnetic field can be used for detecting the magnetic field to change the magnetic field, and the magnetic field can move in the detection sphere has a motion field has a motion driving force has a small magnetic field in the detection field has a small magnetic field.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, detect spheroidal inner chamber middle part and be provided with main control module, be provided with the power in the main control module, the power adopts miniature button cell, sampling part and camera part are all connected with the main control module electricity, main control module is used for controlling sampling part action, and camera part work, and be equipped with bluetooth or radio frequency transmission image and sensor data to external receiver, still can install the external magnetic field control system of the supplementary external equipment portion of positioning sensor track interior detection portion position, sampling part is provided with two and distributes in main control module's upper and lower both sides for sample respectively, camera part is provided with two along detecting spheroidal upper and lower both ends symmetric distribution, 360 panorama image information around can be gathered to two symmetrically arranged panorama camera parts, it is provided with counter weight portion to detect spheroid and magnet portion symmetry.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, the sampling part includes fixed cavity and replacement cavity, fixed cavity fixed mounting is inside detecting the spheroid, be provided with first piston in the fixed cavity, first piston is connected with miniature electric jar, miniature electric jar is connected with the main control module electricity, one side of fixed cavity is provided with the inserted tube rather than the inner chamber intercommunication, detect spheroidal surface and seted up the slot, the replacement cavity is pegged graft in the slot, connecting hole has been seted up to the inside wall of replacement cavity, the inserted tube pegging graft in connecting hole, the inner chamber of replacement cavity is provided with the second piston, and the outside end of replacement cavity is provided with the sample connection, and miniature electric jar flexible drives first piston motion, makes second piston motion through atmospheric pressure to realize absorbing, release action, the accessible sample connection absorbs target position liquid to the replacement cavity in, if pour into the medicine into in the replacement cavity in advance, treat that the internal detection part removes to realize directional function of dosing when reaching, the free dismantlement of replacement cavity is convenient for, the sample connection cavity, the removable is convenient for obtain, the sample cavity can be used as the sample of multiple times, the difficult problem of the difficult sample is avoided each other, the sample is difficult to take a sample, the difficult sample is difficult to use.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, the surface of grafting pipe is provided with sealed damping portion, sealed damping portion is the rubber sealing ring that is the zigzag and arranges on grafting pipe surface, rubber sealing ring is close to the replacement cavity surface and is the slope form that inclines backward from inside to outside, and sealed damping portion plays the sealed effect between grafting pipe and the replacement cavity to through the fixed replacement cavity of frictional force, only need use the instrument with the outward extraction of replacement cavity force during the dismantlement can.
The utility model provides a foretell alimentary canal liquid biopsy sampling device for internal medicine, the tip of sampling mouth outwards protrudes and inside cavity diameter reduces gradually, the sampling mouth inner chamber is provided with the elastic valve that comprises the silica gel piece of closely laminating, and the liquid outflow after the sampling mouth can prevent to absorb by the end structure and the elastic valve of sampling mouth, prevents simultaneously that outside liquid from getting into the liquid sample that pollutes and obtain.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, the inner chamber of fixed cavity is provided with open-top's sealing baffle, first piston and grafting pipe end set up in sealing baffle's both sides, can make first piston longitudinal movement, second piston lateral movement improves first piston effective stroke.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, the main part frame is "U" font, and the spout has all been seted up along length direction to the inside both sides wall of main part frame, the both sides of annular moving part are provided with the slide bar, slide bar slidable mounting is in corresponding spout, slide bar lateral wall can be provided with the bearing and be used for reducing the frictional force with the spout between, be provided with the screw rod along length direction in the spout, the end connection of screw rod has horizontal driving motor, and horizontal driving motor can drive screw rod forward, reverse rotation, rectangular through-hole has been seted up to the slide bar tip, the screw rod runs through rectangular through-hole, the both sides of mutual symmetry all are provided with telescopic part in the rectangular through-hole, telescopic part's medial extremity all is provided with the separation and reunion part, two the surface that the separation and the inslot are provided with the screw thread that corresponds with the screw rod, the screw rod is arranged in between two separation and reunion parts, and telescopic part can drive two separation and clutching part lock when on the screw rod, driving screw rod forward, reverse rotation, can make its annular moving part front and back part separate, can not receive the separation and separate with the screw rod forward and separate when realizing that the annular movement respectively to the screw rod is realized respectively to the screw rod translation.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, the inner chamber rotatable mounting of annular moving part has the ring gear, connecting portion is installed to the ring gear inboard, the tip of connecting portion stretches out annular moving part inside wall and is connected with the electromagnet, the bottom of annular moving part is provided with the mounting box rather than the inner chamber intercommunication, and the main part frame middle part upper surface can be seted up and receive the mounting box and supply its sunken space that removes, be provided with driving motor in the mounting box, driving motor's output is provided with the drive gear who meshes with the ring gear, and driving motor passes through the drive gear and drives the ring gear and rotate, and then realizes the removal of electromagnet along annular moving part inner wall.
The digestive tract liquid biopsy sampling device for the internal medicine is characterized in that the external device is electrically connected with a main controller, a display and power supply equipment.
The utility model provides a digestive tract liquid biopsy sampling device for internal medicine, be provided with the bed body in the main part frame, annular moving part encircles and cup joints in the external side of bed, the surface embedding of bed body is provided with magnetic force sensor, and magnetic force sensor can assist the location of carrying out the magnetic field control of external equipment portion and interior detection portion, magnetic force sensor is connected with the main control unit electricity.
Compared with the prior art, the invention has at least the following beneficial effects:
(1) The inner detection part needing to be swallowed adopts the detection sphere with the built-in magnetic control, is sleeved with the hollowed-out sphere shell, is isotropic and flexible to turn, and the hollowed-out sphere shell rolls to run during movement to reduce friction force, is easy to roll in intestinal folds, can effectively improve the rolling speed and effectively improve the magnetic field driving efficiency.
(2) The spherical body detection device is highly integrated, has simple and reasonable structural design, small and exquisite overall diameter, is easy to swallow, does not need intubation or anesthesia, has high patient acceptance, and simultaneously has multiple functions of integrating, supporting various operations such as imaging, sampling, drug delivery and the like, the invention can collect 360-degree panoramic image information around through the panoramic camera part 7, the sampling part actively and directionally extracts a liquid sample by adopting a miniature electric cylinder and piston structure, the problem of inaccurate sampling is avoided, and the directional drug delivery function of an affected part can be realized.
(3) The invention has the advantages that the replacement cavity is convenient to detach, can be used for conveniently transporting, extracting and storing the acquired liquid, has low cost, can be used as a disposable consumable, can avoid the problems of difficult repeated sampling and cleaning and mutual pollution of sampling liquid, and can prevent the sucked liquid from flowing out by the end closing structure of the sampling port of the replacement cavity and the elastic valve, and simultaneously prevent external liquid from entering the acquired liquid sample.
(4) The external equipment part of the invention comprises a plurality of groups of Helmholtz coils or Maxwell coils to form an electromagnet, a plurality of electromagnets to form a three-dimensional electromagnetic field, the intensity and the direction of the magnetic field are changed by adjusting current, the detection sphere moves axially or radially along the alimentary canal by adjusting the gradient of the external magnetic field, the direction of the magnetic field is changed, the spin of the detection sphere is controlled to adjust the visual angle and the sampling angle of a camera, and the gravity is balanced by the magnetic field in a specific area (such as the stomach bottom), so that the detection sphere is suspended and the mucous membrane surface is comprehensively observed.
(5) The plurality of electromagnets in the external equipment part are arranged in the annular moving part, the movement and the angle of the electromagnets along the inner wall of the annular moving part are realized and controlled by the driving motor, the plurality of annular moving parts are driven to translate forwards and backwards by the screw rod, and the clutch component realizes the independent control of the plurality of annular moving parts.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the structure of the inner detecting section of the present invention;
FIG. 3 is a schematic view of the spherical shell structure of the present invention;
FIG. 4 is a cross-sectional view at A in FIG. 2;
FIG. 5 is an enlarged schematic view of the local structure of the inner detecting section of the present invention;
FIG. 6 is a schematic view of the structure of the plug-in connection between the fixed cavity and the replacement cavity;
FIG. 7 is a schematic view of a sampling port according to the present invention
FIG. 8 is a schematic diagram of the peripheral device structure of the present invention;
FIG. 9 is a schematic view of the horizontal drive motor mounting structure of the present invention;
fig. 10 is a schematic view of the clutch member mounting structure of the present invention.
The reference numerals 1-inner detecting section, 2-outer detecting section, 3-detecting sphere, 4-spherical housing, 5-magnet section, 6-sampling section, 601-fixed cavity, 602-replacement cavity, 603-first piston, 604-micro electric cylinder, 605-plug-in pipe, 606-connection through hole, 607-second piston, 608-sampling port, 609-sealing damping section, 610-elastic valve, 611-sealing baffle, 7-camera section, 8-main body frame, 9-annular moving section, 10-electromagnet, 11-main control module, 12-counterweight section, 13-slot, 14-chute, 15-slide bar, 16-screw, 17-horizontal driving motor, 18-rectangular through hole, 19-telescopic part, 20-clutch part, 21-ring gear, 22-connection section, 23-mounting box, 24-driving motor, 25-driving gear, 26-bed body, 27-main controller, 28-display, 29-power supply equipment.
The invention is further described below with reference to the drawings and the detailed description.
Detailed Description
An embodiment of the invention is an alimentary canal liquid biopsy sampling device for medical use, comprising an inner detection part 1 and an outer peripheral part 2, wherein:
The inner detection part 1 comprises a detection sphere 3 and a spherical shell 4, the diameter of the detection sphere 3 is smaller than that of the spherical shell 4, the detection sphere is arranged in the inner cavity of the spherical shell 4, the spherical shell 4 is hollow, the inner wall and the outer wall are smooth, one end in the detection sphere 3 is provided with a magnet part 5, the magnet part 5 adopts a permanent magnet, the permanent magnet is more stable relative to an electromagnet permanent magnet, the power consumption can be reduced, the whole volume of the inner detection part 1 is reduced, the heating problem is avoided, the magnet part 5 formed by the high magnetic energy product permanent magnet arranged in the detection sphere 3 can interact with an external magnetic field to generate a motion driving force, the motion and the control are carried out through the external magnetic field, the detection sphere 3 is also provided with a sampling part 6 and a camera part 7, the sampling part 6 is used for absorbing alimentary canal liquid, two or more, preferably two or more parts can be symmetrically arranged, the two parts can be used for balancing the volume and function requirements, the two affected parts can be sampled and administrated at one time, the whole time can be controlled in a range of easy to swallow, the whole can be observed by adopting a miniature lens of 360 degrees, accurate sampling and administration can be assisted;
the outer equipment part 2 comprises a main body frame 8, an annular moving part 9 capable of sliding forwards and backwards is arranged on the main body frame 8, an electromagnet 10 capable of moving along the inner side wall of the annular moving part 9 is arranged on the inner side of the annular moving part 9, a controllable magnetic field is generated by the electromagnet 10, the strength and the direction of the magnetic field are changed by moving the position of the electromagnet 10 and adjusting the current of an electromagnetic coil of the electromagnet 10, the external magnetic field interacts with the magnet part 5 in the detection sphere 3 to generate force moment to drive the detection sphere 3 to turn, attractive force or repulsive force generated by magnetic field gradient pushes the detection sphere 3 to move in a translational mode, the inner detection part 1 moves under the action of magnetic force, the detection sphere 3 is positioned in the spherical shell 4, and the spherical shell 4 on the outer side rolls in a patient when the detection sphere 3 moves so as to reduce motion friction, improve the travelling speed and reduce motion energy consumption.
In a preferred embodiment, this embodiment is a medical gut fluid biopsy sampling device, wherein: the inner detection part 1 comprises a detection sphere 3 and a spherical shell 4, the diameter of the detection sphere 3 is smaller than that of the spherical shell 4 and is arranged in the inner cavity of the spherical shell 4, the spherical shell 4 is hollow, the inner wall and the outer wall are smooth, one end in the detection sphere 3 is provided with a magnet part 5, the magnet part 5 adopts a permanent magnet, is more stable relative to the permanent magnet of an electromagnet, can reduce the power consumption, reduce the whole volume of the inner detection part 1, avoid the heating problem, the magnet part 5 formed by the permanent magnet with high magnetic energy product in the detection sphere 3 can interact with an external magnetic field to generate a motion driving force, the motion and the control are carried out through the external magnetic field, the detection sphere 3 is also provided with a sampling part 6 and a camera part 7, the sampling part 6 is used for absorbing alimentary canal liquid, the sampling part 6 can be symmetrically provided with two or more, preferably two requirements of volume and function can be balanced, the two affected parts can be sampled at one time respectively, or sampling and drug administration can be carried out simultaneously, the volume can be controlled in a range easy to swallow, the camera part 7 adopts a 360-degree miniature lens, panoramic observation can be carried out, accurate sampling and drug administration can be assisted, the middle part of the inner cavity of the detection sphere 3 is provided with a main control module 11, a power supply is arranged in the main control module 11, the power supply adopts a miniature button battery, the sampling part 6 and the camera part 7 are electrically connected with the main control module 11, the main control module 11 is used for controlling the action of the sampling part 6, the camera part 7 works and is provided with Bluetooth or radio frequency transmission images and sensor data to an external receiver, an external magnetic field control system of the positioning sensor auxiliary external equipment part 2 can be additionally arranged for tracking the position of the internal detection part 1, the sampling part 6 is provided with two upper and lower both sides that distribute in the main control module 11 for sample respectively, the portion of making a video recording 7 is provided with two upper and lower both ends symmetric distributions along detecting spheroid 3, and 360 panoramic image information around can gathering to two symmetric arrangement's panoramic image portion 7, and the image is through the chip compression back, sends external receiver through radio signal, supplies the doctor to look over in real time.
Specifically, the sampling portion 6 includes fixed cavity 601 and replacement cavity 602, fixed cavity 601 fixed mounting is in detecting spheroid 3 inside, be provided with first piston 603 in the fixed cavity 601, first piston 603 is connected with miniature electric jar 604, miniature electric jar 604 is connected with main control module 11 electricity, one side of fixed cavity 601 is provided with the grafting pipe 605 rather than the inner chamber intercommunication, slot 13 has been seted up on the surface of detecting spheroid 3, replacement cavity 602 is pegged graft in slot 13, the connecting through-hole 606 has been seted up to the inside wall of replacement cavity 602, grafting pipe 605 is pegged graft in connecting through-hole 606, the inner chamber of replacement cavity 602 is provided with second piston 607, and the outside end of replacement cavity 602 is provided with sampling mouth 608, miniature electric jar 604 stretches out and draws back and drives first piston 603 and move, make second piston 607 move through atmospheric pressure, thereby realize sucking the release action, accessible sampling mouth 608 draws target position liquid to replace cavity 602 in, if pour into the medicine into in advance, can realize directional medicine delivery function when waiting for interior detection portion 1 to remove to the affected part, simultaneously replace cavity 602 can freely dismantle, the transportation is convenient for obtaining, the sample cavity 602 is difficult to take a sample, the difficult sample, can be avoided the sample is difficult to the sample with low costs of each other, can be used as the sample is difficult to clean each other.
Specifically, the outer surface of the plug tube 605 is provided with a sealing damping portion 609, the sealing damping portion 609 is a rubber sealing ring which is arranged on the surface of the plug tube 605 in a zigzag manner, the rubber sealing ring is inclined backwards from inside to outside and close to the surface of the replacement cavity 602, the sealing damping portion 609 plays a sealing role between the plug tube 605 and the replacement cavity 602, the replacement cavity 602 is fixed through friction force, and when the plug tube is disassembled, only a tool is needed to draw the replacement cavity 602 outwards.
Specifically, the end portion of the sampling port 608 protrudes outwards, the diameter of the internal cavity is gradually reduced, an elastic valve 610 formed by a tightly attached silica gel sheet is arranged in the inner cavity of the sampling port 608, the end portion structure of the sampling port 608 and the elastic valve 610 can prevent the sucked liquid from flowing out, and meanwhile, external liquid is prevented from entering the liquid sample obtained by pollution.
Specifically, the inner cavity of the fixed cavity 601 is provided with a sealing baffle 611 with an open top, and the ends of the first piston 603 and the plug tube 605 are arranged at two sides of the sealing baffle 611, so that the first piston 603 can longitudinally move, and the second piston 607 transversely moves, thereby improving the effective stroke of the first piston 603.
In a preferred embodiment, the digestive tract liquid biopsy sampling device for internal medicine comprises an external device 2, an internal detection part 1 and an external device 2, wherein the external device comprises a main body frame 8, an annular moving part 9 capable of sliding back and forth is arranged on the main body frame 8, an electromagnet 10 capable of moving along the inner side wall of the annular moving part 9 is arranged on the inner side of the annular moving part 9, the electromagnet 10 generates a controllable magnetic field, the strength and the direction of the magnetic field are changed by moving the position of the electromagnet 10 and adjusting the electromagnetic coil current of the electromagnet 10, the external magnetic field interacts with the internal magnet part 5 of the detection sphere 3 to generate torque to drive the detection sphere 3 to turn, attractive force or repulsive force generated by magnetic field gradient pushes the detection sphere 3 to move in translation, the internal detection sphere 3 moves under the action of magnetic force, the external device 2 is electrically connected with a main controller 27, a display 28 and a power supply device 29, and the external device 2 rolls in the patient to reduce motion friction when the detection sphere 3 moves.
Specifically, the main body frame 8 is "U" font, the spout 14 has all been seted up along length direction to the inside both sides wall of main body frame 8, the both sides of annular moving part 9 are provided with slide bar 15, slide bar 15 slidable mounting is in corresponding spout 14, slide bar 15 lateral wall can be provided with the bearing and be used for reducing the frictional force with spout 14, be provided with screw rod 16 along length direction in the spout 14, the end connection of screw rod 16 has horizontal driving motor 17, horizontal driving motor 17 can drive screw rod 16 forward, the reverse rotation, rectangular through-hole 18 has been seted up to slide bar 15 tip, screw rod 16 runs through rectangular through-hole 18, both sides that are symmetrical each other in the rectangular through-hole 18 all are provided with telescopic part 19, the inboard end of telescopic part 19 all is provided with clutch parts 20, the surface that two clutch parts 20 are relative is provided with the recess, and be provided with the screw thread that corresponds with screw rod 16 in the recess, screw rod 16 is arranged between two clutch parts 20, telescopic part 19 can drive two clutch parts 20 lock or separate, when two clutch parts 20 lock on screw rod 16, horizontal driving motor 17 drive screw rod 16 forward and reverse rotation, can make its annular moving part 9 front and back part 20 separate, the single drive screw rod 16 can not be separated, the translation is realized to the screw rod 16 respectively.
Specifically, the inner cavity of the annular moving part 9 is rotatably provided with the annular gear 21, the inner side of the annular gear 21 is provided with the connecting part 22, the end part of the connecting part 22 extends out of the inner side wall of the annular moving part 9 and is connected with the electromagnet 10, the bottom of the annular moving part 9 is provided with the installation box 23 communicated with the inner cavity of the annular moving part, the installation box 23 is internally provided with the driving motor 24, the output end of the driving motor 24 is provided with the driving gear 25 meshed with the annular gear 21, and the driving motor 24 drives the annular gear 21 to rotate through the driving gear 25, so that the electromagnet 10 moves along the inner wall of the annular moving part 9.
Specifically, the main body frame 8 is internally provided with a bed body 26, the annular moving part 9 is sleeved outside the bed body 26 in a surrounding manner, the surface of the bed body 26 is embedded with a magnetic force sensor, the magnetic force sensor can assist in controlling the magnetic field of the external equipment part 2 and positioning the internal detection part 1, and the magnetic force sensor is electrically connected with the main controller 27.
The foregoing description of the preferred embodiments of the application is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the application.
In the application process, a patient swallows the inner detection part 1 according to a doctor's advice and lays on the bed body 26, the external equipment part 2 is started, the image information is acquired through the camera part 7 to be positioned, the auxiliary positioning can be realized according to the positioning sensor, the magnetic field intensity and the direction are changed through moving the position of the electromagnet 10 and adjusting the electromagnetic coil current of the electromagnet 10, the external magnetic field interacts with the inner magnet part 5 of the detection sphere 3, the detection sphere 3 moves or turns when the driving force is generated, the inner detection part 1 moves under the action of magnetic force, the detection sphere 3 is positioned in the spherical shell 4, the outer spherical shell 4 rolls and moves in the patient when the detection sphere 3 moves, so that the motion friction is reduced, and the advancing speed is improved, wherein the specific working principle and flow of the inner part and the outer part are as follows:
The inner detection part 1 can send the camera part 7 to collect image information in real time after the inner detection part 1 enters a patient, sends the image information to the external receiver through a wireless signal for the doctor to check in real time, and when the doctor controls the inner detection part 1 to move to an affected part according to the positioning information and the image information, the doctor adjusts the angle of the detection sphere 3 to enable the end part of the sampling port 608 to be opposite to liquid to be sampled, the micro electric cylinder 603 is started to shrink, the first piston 603 and the second piston 607 move to suck the liquid to the replacement cavity 602, the end part structure of the sampling port 608 and the elastic valve 610 can prevent the sucked liquid from flowing out, and simultaneously prevent the external liquid from entering the liquid sample which is polluted, and can also control the micro electric cylinder 603 to stretch when the inner detection part 1 is positioned outside the body and the affected part in the body, so that the medicine is pushed to the affected part from the replacement cavity 602, after all the required liquid is sampled, the inner detection part 1 can be controlled to quickly move in the digestive tract to assist to be discharged, after the liquid is discharged, the hook-shaped needle, the replacement cavity 602 can be pulled out of the liquid sample cavity 602, and the problem of difficult sample can be cleaned by one-time can be avoided, and the problem of cleaning can be solved.
The external equipment part 2 comprises an electric element for the whole external equipment part 2, a main controller 27 and a display 28, wherein the power supply equipment 29 is started to supply power to the electric element of the whole external equipment part 2, the main controller 27 can receive information transmitted by the internal detection part 1 and transmit control information to the internal detection part 1, the display 28 can display image information and control information of all electric control parts, so that a doctor can observe and operate and control conveniently, the electromagnet 10 is moved and the direction is changed by moving the electromagnet 10 and adjusting the electromagnetic coil current of the electromagnet 10, the detection sphere 3 is controlled to move and steer and the like, wherein the horizontal driving motor 17 can drive the screw 16 to rotate, when the two clutch parts 20 are buckled on the screw 16, the driving motor 17 is controlled to drive the screw 16 to rotate in the forward and reverse directions, the annular moving parts 9 corresponding to the buckling clutch parts 20 can move forwards and backwards, and can be separated from the screw 16 without being controlled by the screw 16, so that a single screw 16 can respectively carry out forward and backward translational driving on the annular moving parts 9, the driving motor 24 is provided with a driving gear 25 meshed with the annular gear 21, the driving motor 24 is driven by the driving motor 24, and the driving motor 24 can drive the driving gear 21 to drive the annular part to rotate along the annular inner wall 10 through the driving gear 21.
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510457167.9A CN120570632A (en) | 2025-04-13 | 2025-04-13 | A digestive tract liquid biopsy sampling device for internal medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510457167.9A CN120570632A (en) | 2025-04-13 | 2025-04-13 | A digestive tract liquid biopsy sampling device for internal medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN120570632A true CN120570632A (en) | 2025-09-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510457167.9A Withdrawn CN120570632A (en) | 2025-04-13 | 2025-04-13 | A digestive tract liquid biopsy sampling device for internal medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN120570632A (en) |
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2025
- 2025-04-13 CN CN202510457167.9A patent/CN120570632A/en not_active Withdrawn
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Application publication date: 20250902 |