CN119949839B - Method for producing an electro-oculogram signal sensor and electro-oculogram signal sensor - Google Patents
Method for producing an electro-oculogram signal sensor and electro-oculogram signal sensorInfo
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- CN119949839B CN119949839B CN202510244857.6A CN202510244857A CN119949839B CN 119949839 B CN119949839 B CN 119949839B CN 202510244857 A CN202510244857 A CN 202510244857A CN 119949839 B CN119949839 B CN 119949839B
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Abstract
本申请公开了一种用于制备眼电信号传感器的方法及眼电信号传感器。该方法包括：提供柔性衬底前驱体溶液，柔性衬底前驱体溶液包括聚合物和有机溶剂；通过静电纺丝工艺对柔性衬底前驱体溶液进行纺织，得到厚度为50nm～10μm的柔性衬底；在柔性衬底表面设置厚度为100nm～500nm的导联电极，得到眼电信号传感器。本申请的方法制作流程简单，成本效益高，且能够实现眼电信号传感器的无感化佩戴的设计目标。
This application discloses a method for preparing an electrooculogram (EOG) sensor and the EOG sensor. The method comprises: providing a flexible substrate precursor solution comprising a polymer and an organic solvent; spinning the flexible substrate precursor solution via an electrospinning process to obtain a flexible substrate having a thickness of 50 nm to 10 μm; and disposing lead electrodes having a thickness of 100 nm to 500 nm on the surface of the flexible substrate to obtain the EOG sensor. This method has a simple production process, is cost-effective, and achieves the design goal of a wearable EOG sensor.
Description
Technical Field
The application belongs to the technical field of biological sensors, and particularly relates to a method for preparing an electro-oculogram signal sensor and the electro-oculogram signal sensor.
Background
With the increasing of the keeping amount of motor vehicles, the traffic accident rate caused by fatigue driving is rising year by year, the proportion of the total number of traffic accidents is more than 20%, and the proportion of the major traffic accidents is more than 40%. Of the traffic accidents caused by excuse me, nearly 90% are caused by failure to respond in time when the driver enters a fatigue state. Studies have shown that by analyzing the driver's eye movement patterns, such as the frequency of eye closure, instantaneous closure time, eye movement, and pupil response, the fatigue level can be effectively assessed. Therefore, there is a need for an apparatus that is easy to wear and monitors in real time whether the driver is tired. The human eye can provide physiological information of the body to the outside, so that the fatigue state can be rapidly detected by eye movement and blinking. Electrooculogram (electrooculogram, EOG) sensing is increasingly being used in fatigue monitoring systems due to its non-invasive, easy to wear and real-time monitoring characteristics.
The eye electrical signal is derived from the potential difference between retina and cornea, is a convenient and quick method for measuring eye movement, can reflect the conditions of reading state, sleep mode, brain condition, drowsiness, eye fatigue and the like, and can be used for fatigue early warning, man-machine interaction, disease diagnosis (such as diagnosis of hyperkinetic syndrome, apoplexy, autism, alzheimer disease and parkinsonism) and the like.
Conventional electrooculogram signal sensors typically use metal electrodes to collect EOG signals, such as silver/silver chloride (Ag/AgCl) gel electrodes, which are also commercially available dry or wet silver/silver chloride electrodes used for electrooculogram measurement in most practical applications today, although they are relatively simple and inexpensive to manufacture, they are too heavy, cumbersome, stiff and uncomfortable to attach to delicate skin around the eyes, and are quite visible on the face, affecting overall aesthetics. In addition, for wet electrodes, it is necessary to apply grease and cutin to the face before wearing, the gel stimulates the skin, and the wet electrode dries out over time, resulting in a decrease in the quality of recorded signals. Whereas dry electrodes have a high electrode-skin contact resistance due to their non-compliant contact with the skin and are susceptible to motion artifacts. For example, searle A and Kirkup L designed ultra-thin and stretchable tattoo-style electro-oculography based on a polymer-based filamentous serpentine gold ribbon, which is very attractive for application in prominent areas such as the human face. In other studies, EOG sensors were integrated with other sensors and circuit elements on a patch of a few millimeters in thickness, which was not only apparent, but also stiff, which prevented facial expression. Therefore, there is a need to develop a flexible epidermis sensor for non-inductive electrooculography detection.
Disclosure of Invention
In order to solve the problems, the application provides a method for preparing an electro-oculogram signal sensor and the electro-oculogram signal sensor. The method applies the traditional electrostatic spinning technology to the manufacture of the flexible microelectronic device at the front edge, has simple manufacturing flow and high cost efficiency, and can realize the design target of non-inductive wearing of the electro-oculogram signal sensor.
A first aspect of the present application provides a method for preparing an electro-ocular signal sensor, comprising:
Providing a flexible substrate precursor solution comprising a polymer and an organic solvent;
Spinning the precursor solution of the flexible substrate through an electrostatic spinning process to obtain a flexible substrate with the thickness of 50 nm-10 mu m;
And arranging a lead electrode with the thickness of 100-500 nm on the surface of the flexible substrate to obtain the electro-oculogram signal sensor.
The method of the application weaves the precursor solution of the flexible substrate through the electrostatic spinning process to obtain the flexible substrate with the thickness of 50 nm-10 mu m, and the manufacturing flow of the substrate is simple and has higher cost benefit. The electro-oculogram signal sensor prepared by the method provided by the application consists of a nanoscale or micron-sized flexible substrate and a nanoscale lead electrode, and the thin design of the electro-oculogram signal sensor not only improves the air permeability of the device, but also reduces the Young modulus of the device. Therefore, the electro-oculogram signal sensor prepared by the method can have wider application environment, and can be always attached to the skin in a conformal way in the use process, so that the design target of non-inductive wearing can be achieved, and the electro-oculogram signal sensor has good service performance.
In any embodiment of the present application, there is provided a flexible substrate precursor solution comprising:
and dissolving the polymer in an organic solvent to obtain a flexible substrate precursor solution with the mass concentration of 5% -30%.
In any embodiment of the application, the polymer comprises one or more of polyurethane, polyethylene terephthalate and polyimide;
The organic solvent comprises one or more of N, N-dimethylacetamide, N-dimethylformamide and chloroform.
In any embodiment of the application, the flexible substrate comprises polymer fibers having a diameter of 50nm to 10 μm.
In any embodiment of the present application, a lead electrode having a thickness of 100nm to 500nm is provided on a surface of a flexible substrate, comprising:
And depositing a metal film on the surface of the flexible substrate according to a preset electrode layout to form a lead electrode with the thickness of 100-500 nm.
In any embodiment of the present application, after disposing the lead electrode on the surface of the flexible substrate, the method further comprises:
An adhesive layer with a hollowed-out portion is arranged on one side of the flexible substrate, which faces the lead electrode, wherein the hollowed-out portion exposes a part of the lead electrode.
In any embodiment of the present application, the adhesive layer includes a polymer substrate and a pressure sensitive layer on a surface of the polymer substrate.
In any embodiment of the application, the flexible substrate comprises a first flexible substrate;
providing a lead electrode on the surface of a flexible substrate, including providing a first lead electrode and a second lead electrode on the surface of a first flexible substrate;
The first lead electrode comprises a first external electrode, a first connecting electrode and a first action electrode, wherein the first external electrode is rectangular, triangular, diamond-shaped or circular, the first external electrode is used for being connected with the signal acquisition device, the first action electrode is rectangular, triangular, diamond-shaped or circular, the first action electrode is used for acquiring an electro-oculogram signal, the first connecting electrode is rectangular, and the first connecting electrode is used for connecting the first external electrode and the first action electrode;
The second lead electrode comprises a second external electrode, a second connecting electrode and a second action electrode, wherein the second external electrode is rectangular, triangular, diamond-shaped or circular, and the second external electrode is used for being connected with the signal acquisition device;
the first external electrode and the second external electrode are opposite along the first direction, and the first action electrode and the second action electrode are opposite along the first direction, and the distance between the first external electrode and the second external electrode is smaller than the distance between the first action electrode and the second action electrode in the first direction.
In any embodiment of the application, the flexible substrate further comprises a second flexible substrate, wherein the surface of the flexible substrate is provided with a lead electrode, and the flexible substrate further comprises a third lead electrode, a fourth lead electrode and a third lead electrode;
The third lead electrode comprises a third external electrode, a third connecting electrode and a third action electrode, wherein the third external electrode is rectangular, triangular, diamond-shaped or circular, the third external electrode is used for being connected with the signal acquisition device, the third action electrode is rectangular, triangular, diamond-shaped or circular, the third action electrode is used for acquiring an electro-oculogram signal, the third connecting electrode is rectangular, and the third connecting electrode is used for connecting the third external electrode and the third action electrode;
The fourth lead electrode comprises a fourth external electrode, a fourth connecting electrode and a fourth action electrode, the fourth external electrode is rectangular, triangular, diamond-shaped or circular, the fourth external electrode is used for being connected with the signal acquisition device, the fourth action electrode is rectangular, triangular, diamond-shaped or circular, the fourth action electrode is used for acquiring an eye electric signal, the fourth connecting electrode is rectangular, and the fourth connecting electrode is used for connecting the fourth external electrode and the fourth action electrode;
The fourth lead electrode is arranged opposite to the third lead electrode along a second direction, and the second direction is perpendicular to the first direction.
A second aspect of the application provides an electro-ocular signal sensor prepared in accordance with the method of any of the embodiments of the first aspect.
Drawings
FIG. 1 is a schematic view of a first lead member of an electro-oculography sensor according to an embodiment of the application;
FIG. 2 is a schematic diagram of a second lead member of an electro-oculography sensor according to another embodiment of the application;
FIG. 3 is a schematic diagram of an electro-oculogram signal sensor according to another embodiment of the present application;
FIG. 4 is an electrode layout of an electro-oculogram signal sensor provided in accordance with yet another embodiment of the present application;
FIG. 5 is an optical microscope image of the edge position of a first flexible substrate in an electro-oculogram signal sensor provided in accordance with yet another embodiment of the present application;
FIG. 6 is an optical microscope image of the center position of a first flexible substrate in an electro-oculogram signal sensor provided in accordance with yet another embodiment of the present application;
FIG. 7 is a metallographic microscope image of a first flexible substrate at 5 magnification in an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 8 is a metallographic microscope image of a first flexible substrate at 10 magnification in an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 9 is a metallographic microscope image of a first flexible substrate at 20 magnification in an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 10 is a metallographic microscope image at 50 magnification of a first flexible substrate in an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 11 is a scanning electron microscope image of a first flexible substrate in an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 12 is a schematic view of an attachment position of an electro-oculogram signal sensor according to yet another embodiment of the present application;
FIG. 13 is a schematic diagram of an electro-oculogram sensor test platform according to yet another embodiment of the present application;
FIG. 14 is a graph of EOG signal test results for vertical eye movement detected by an electro-oculogram signal sensor according to another embodiment of the present application;
FIG. 15 is a graph of EOG signal test results for eye level movement detected by an electro-oculogram signal sensor according to another embodiment of the present application;
FIG. 16 is a graph of EOG signal test results for diagonal eye movement detected by an electro-oculogram signal sensor according to another embodiment of the present application;
FIG. 17 is a scatter plot of eye movement slope characteristics detected by an electro-oculogram signal sensor provided in accordance with yet another embodiment of the present application;
FIG. 18 is a graph of blink signal test results detected by an electro-oculogram signal sensor according to yet another embodiment of the present application;
Fig. 19 is a time domain diagram of a single blink signal for different blink states detected by an electrical ocular signal sensor according to yet another embodiment of the present application.
In the drawings, the drawings are not necessarily to scale.
Detailed Description
In order to make the application object, technical scheme and beneficial technical effects of the application clearer, the application is further described in detail with reference to the following embodiments. It should be understood that the examples described in this specification are for the purpose of illustrating the application only and are not intended to limit the application.
For simplicity, only a few numerical ranges are explicitly disclosed. However, any lower limit may be combined with any upper limit to form a range not explicitly recited, and any lower limit may be combined with any other lower limit to form a range not explicitly recited, as may any upper limit combined with any other upper limit. Furthermore, each point or individual value between the endpoints of the range is included within the range, although not explicitly recited. Thus, each point or individual value may be combined as a lower or upper limit on itself with any other point or individual value or with other lower or upper limit to form a range that is not explicitly recited.
In the description of the present application, unless otherwise indicated, "above" and "below" are intended to include the present number, and the meaning of "multiple" in "one or more" means two or more.
The above summary of the present application is not intended to describe each disclosed embodiment or every implementation of the present application. The following description more particularly exemplifies illustrative embodiments. Guidance is provided throughout this application by a series of embodiments, which may be used in various combinations. In the various examples, the list is merely a representative group and should not be construed as exhaustive.
As described in the background, under current technological development, there is a need to develop a flexible epidermis sensor for non-inductive electrooculography detection.
The related art relates to a skin attachment sensor based on a single crystal III-N film for eye movement monitoring, which converts various blink frequencies and skin deformation caused by eye movement into electrical signals for output. However, the sensor requires Polydimethylsiloxane (PDMS) encapsulation, which can result in excessive sensor thickness and poor adhesion.
The related art also relates to the collection of EOG signals by Graphene Electronic Tattoos (GETs) for human-machine interaction to control the flight of a four-axis aircraft. GET sensors with a thickness of 350nm show an optical transparency of 85% and a stretchability of 50% in the visible region. However, the GET preparation process requires complicated process steps (up to 27 steps), and GET performance stability of single-layer graphene preparation is difficult to control. Therefore, GET sensors based on chemical vapor deposition growth are costly to produce. Furthermore, the interconnection and protection of ultra-thin bare GETs remains a significant challenge.
In summary, while many research teams have conducted research on flexible-skin-type electro-oculography, the clinical stage is not yet reached. Many studies have employed multi-layered stacked deposited metal electrodes and polymer material encapsulated electro-oculogram sensors, but they still present several problems of complicated manufacturing process, poor stability, and inability to wear for a long period of time due to heavy materials and volumes, etc. At present, electrodes (such as metal sheet electrodes and gel patch electrodes) and lead wires adopted by electrooculography in laboratories or hospitals are too thick and hard, so that the use comfort is low, the skin thin film electronic device is difficult to wear for a long time, and the research on the electrooculography long-term noninductive measurement is still deficient.
In view of this, the inventors have conducted intensive studies and a great deal of experiments to provide a method for manufacturing an electro-oculogram signal sensor and an electro-oculogram signal sensor.
The first aspect of the application provides a method for preparing an electro-oculogram signal sensor, comprising the following steps S10-S30.
S10, providing a flexible substrate precursor solution, wherein the flexible substrate precursor solution comprises a polymer and an organic solvent.
In step S10, the polymer may include any polymer known in the art that can be used for a flexible substrate, as long as the polymer solution is suitable for an electrospinning process, and the prepared substrate satisfies the air permeability, biocompatibility, and stretchability requirements, which are not limited herein. The organic solvent may include any organic solvent that can be used to dissolve the above-mentioned polymers, and a person skilled in the art may select an appropriate organic solvent according to the kind of polymer, which is not limited herein.
And S20, spinning the precursor solution of the flexible substrate through an electrostatic spinning process to obtain the flexible substrate with the thickness of 50 nm-10 mu m.
In step S20, the polymer fiber with the diameter in the proper range can be obtained by adjusting and controlling parameters of the electrostatic spinning process, the concentration of the precursor solution of the flexible substrate, and the like, so that the flexible substrate with the thickness in the above range is obtained by spinning. In the electrostatic spinning process, the injection speed of the solution in the injector can be 0.1-0.3 mm/min, the translation speed of the injector can be 50-350 mm/min, the speed of the fiber receiving metal cylinder can be 40-80 mm/min, the distance between the injector and the fiber receiving metal cylinder can be 15-30 cm, the spinning voltage can be positive pressure 5-20 kV, and negative pressure-5-0 kV. The spinning time period can be adjusted as required, and can be about 1 hour, for example.
And S30, arranging a lead electrode with the thickness of 100-500 nm on the surface of the flexible substrate to obtain the electro-oculogram signal sensor.
The method of the application weaves the precursor solution of the flexible substrate through the electrostatic spinning process to obtain the flexible substrate with the thickness of 50 nm-10 mu m, and the manufacturing flow of the substrate is simple and has higher cost benefit. The electro-oculogram signal sensor prepared by the method provided by the application consists of a nanoscale or micron-sized flexible substrate and a nanoscale lead electrode, and the thin design of the electro-oculogram signal sensor not only improves the air permeability of the device, but also reduces the Young modulus of the device. Therefore, the electro-oculogram signal sensor prepared by the method can have wider application environment, and can be always attached to the skin in a conformal way in the use process, so that the design target of non-inductive wearing can be achieved, and the electro-oculogram signal sensor has good service performance.
In some embodiments, providing a flexible substrate precursor solution may include:
and dissolving the polymer in an organic solvent to obtain a flexible substrate precursor solution with the mass concentration of 5% -30%.
Preferably, in some embodiments, the mass concentration of the polymer may also be 6% -18%.
Without intending to be limited by any theory or explanation, when the mass concentration of the polymer in the flexible substrate precursor solution is within the above-described suitable range, it is advantageous to combine with the electrospinning process to obtain polymer fibers having a diameter of 50nm to 10 μm. Therefore, the flexible substrate of single-layer fiber is obtained by spinning, and the air permeability requirement is further met. Thus, the long-term non-inductive wearing of the electro-oculogram signal sensor is facilitated.
In some embodiments, the polymer may include one or more of Polyurethane (PU), polyethylene terephthalate (PET), polyimide (PI).
The organic solvent may include one or more of N, N-Dimethylacetamide (DMF), N-dimethylformamide (DMAc), and chloroform (TCM).
In some embodiments, the flexible substrate may include polymer fibers having a diameter of 50nm to 10 μm.
In the present application, the diameter of the polymeric fiber may represent the range of diameters of the polymeric fibers in the flexible substrate, which may be determined by methods and instruments known in the art. For example, a SEM image of the flexible substrate may be taken by Scanning Electron Microscopy (SEM), a number (e.g., 3, 5, 10, etc.) of test areas may be randomly selected, the diameter of the fibers in the field of view may be determined, and the diameter range of the fibers in all of the test areas may be used as the diameter range of the polymer fibers in the flexible substrate.
In some embodiments, a lead electrode with a thickness of 100 nm-500 nm is arranged on the surface of the flexible substrate, which specifically includes:
And depositing a metal film on the surface of the flexible substrate according to a preset electrode layout to form a lead electrode with the thickness of 100-500 nm.
The deposition can be realized by vacuum sputtering, magnetron sputtering, physical vapor deposition, chemical plating and other processes. The metal film may include metals such as platinum (Pt), gold (Au), and copper (Cu).
According to the embodiment, the metal film is deposited on the surface of the flexible substrate according to the preset electrode layout. Therefore, the process flow of the electro-oculogram signal sensor can be further simplified, the production cost of the electro-oculogram signal sensor is reduced, and the performance stability of the electro-oculogram signal sensor is improved.
In some embodiments, after disposing the lead electrode on the surface of the flexible substrate, the method may further comprise:
An adhesive layer with a hollowed-out portion is arranged on one side of the flexible substrate, which faces the lead electrode, wherein the hollowed-out portion exposes a part of the lead electrode.
It will be appreciated that the lead electrodes may include an external electrode for connection to the signal acquisition device and an active electrode for acquisition of an ocular signal. The hollowed-out part at least can expose the external electrode and the action electrode so that the external electrode and the action electrode can be contacted with skin.
According to the above embodiment, the adhesive layer having the hollowed-out portion is provided on the side of the flexible substrate facing the lead electrode, whereby the electro-oculogram signal sensor can be firmly attached to the skin of the human body by the adhesive action of the adhesive layer. Thus, the electro-oculogram signal sensor can meet the requirement of long-term wearing.
In some embodiments, the adhesive layer may include a polymer substrate and a pressure sensitive layer on a surface of the polymer substrate.
The above-described polymer substrate may include a fibrous film prepared by an electrospinning process, for example, the material and structure of the polymer substrate may be the same as those of the flexible substrate. In one example, the thickness of the polymer substrate may be 50nm to 10 μm.
The pressure sensitive layer may include a pressure sensitive adhesive material, for example, may include one or more of Polydimethylsiloxane (PDMS), acrylate pressure sensitive adhesive, hydrocolloid medical pressure sensitive adhesive, and the like.
Illustratively, disposing an adhesive layer having a hollowed-out portion on a side of the flexible substrate facing the lead electrode may specifically include:
And (3) dripping the pressure-sensitive adhesive solution with the mass concentration of 15% -30% on the surface of the polymer substrate with the hollowed-out part to obtain the adhesive layer.
The adhesive layer is attached to a side of the flexible substrate facing the lead electrode.
It will be appreciated that the polymeric substrate is thin and has good breathability and that both sides of the adhesive layer may have good adhesion.
In some embodiments, the flexible substrate may include a first flexible substrate.
The disposing of the lead electrode on the surface of the flexible substrate may specifically include disposing a first lead electrode and a second lead electrode on the surface of the first flexible substrate.
The first lead electrode may include a first external electrode, a first connection electrode, and a first action electrode, where the first external electrode is rectangular, triangular, diamond or circular, and the first external electrode is used to connect with the signal acquisition device, the first action electrode is rectangular, triangular, diamond or circular, and the first action electrode is used to acquire an electro-oculogram signal, the first connection electrode is rectangular, and the first connection electrode is used to connect the first external electrode and the first action electrode.
The second lead electrode may include a second external electrode, a second connection electrode, and a second action electrode, where the second external electrode is rectangular, triangular, diamond or circular, and the second external electrode is used to connect with the signal acquisition device, the second action electrode is rectangular, triangular, diamond or circular, and the second action electrode is used to acquire an electro-oculogram signal, the second connection electrode is rectangular, and the second connection electrode is used to connect the second external electrode with the second action electrode.
The first external electrode and the second external electrode are opposite along the first direction, and the first action electrode and the second action electrode are opposite along the first direction, and the distance between the first external electrode and the second external electrode is smaller than the distance between the first action electrode and the second action electrode in the first direction.
It will be appreciated that the connection of the first and second external electrodes to the signal acquisition device may be achieved by methods known in the art. The first external electrode and the second external electrode may be connected to the signal acquisition device by a wired connection or a wireless connection. In one example, the electro-ocular signal sensor may further comprise a lead wire that may be used to connect the first external electrode and the signal acquisition device, and the second external electrode and the signal acquisition device, respectively.
According to the above embodiment, the first and second lead electrodes have a specific shape, and the structure of the lead electrode can be made more compact. Therefore, on one hand, the visual effect of the electro-oculogram signal sensor can be weakened, and on the other hand, the use of electrode materials can be reduced, so that the electro-oculogram signal sensor is lighter, thinner and softer. The electro-oculogram signal sensor provided by the embodiment of the application has the advantages of simple structure, easiness in batch preparation, light weight, softness and simplicity, and is beneficial to realizing long-term non-inductance measurement of the electro-oculogram signal.
In some embodiments, the flexible substrate may further comprise a second flexible substrate. The disposing of the lead electrode on the surface of the flexible substrate may further include disposing a third lead electrode on the surface of the first flexible substrate and disposing a fourth lead electrode on the surface of the second flexible substrate.
The third lead electrode may include a third external electrode, a third connection electrode, and a third action electrode, where the third external electrode is rectangular, triangular, diamond, or circular, and the third external electrode is used to connect with the signal acquisition device, the third action electrode is rectangular, triangular, diamond, or circular, and the third action electrode is used to acquire an electro-oculogram signal, the third connection electrode is rectangular, and the third connection electrode is used to connect the third external electrode and the third action electrode.
The fourth lead electrode may include a fourth external electrode, a fourth connection electrode, and a fourth action electrode, where the fourth external electrode is rectangular, triangular, diamond, or circular, and the fourth external electrode is used to connect with the signal acquisition device, the fourth action electrode is rectangular, triangular, diamond, or circular, and the fourth action electrode is used to acquire an electrooculogram signal, the fourth connection electrode is rectangular, and the fourth connection electrode is used to connect the fourth external electrode and the fourth action electrode.
The fourth lead electrode is arranged opposite to the third lead electrode along a second direction, and the second direction is perpendicular to the first direction.
It will be appreciated that the connection of the third external electrode and the fourth external electrode to the signal acquisition device may be achieved by methods known in the art. The third external electrode and the fourth external electrode may be connected to the signal acquisition device by a wired connection or a wireless connection. For example, the third external electrode and the fourth external electrode may be connected to the signal acquisition device by leads, respectively.
In the above embodiment, the first flexible substrate and the second flexible substrate may be two independent components. The first flexible substrate and the first, second and third lead electrodes disposed on the surface of the first flexible substrate may constitute a first lead part, and the second flexible substrate and the fourth lead electrode disposed on the surface of the second flexible substrate may constitute a second lead part.
Fig. 1 shows a schematic structural diagram of a first lead part 01 in an electro-oculogram signal sensor according to an embodiment of the present application.
As shown in fig. 1, the first lead part 01 includes a first flexible substrate 10 and an electrode 20 located on a surface of the first flexible substrate 10. The electrode 20 includes a first lead electrode 21, a second lead electrode 22, and a third lead electrode 23.
The first lead electrode 21 includes a first external electrode 21a, a first connection electrode 21b, and a first action electrode 21c. The first external electrode 21a is rectangular, triangular, diamond-shaped or circular, and the first external electrode 21a is used for connecting with a signal acquisition device. The first active electrode 21c is rectangular, triangular, diamond-shaped or circular, and the first active electrode 21c is used for collecting an electro-oculogram signal. The first connection electrode 21b is rectangular, and the first connection electrode 21b is for connecting the first external electrode 21a and the first action electrode 21c.
The second lead electrode 22 includes a second external electrode 22a, a second connection electrode 22b, and a second action electrode 22c. The second external electrode 22a is rectangular, triangular, diamond-shaped or circular, and the second external electrode 22a is used for connecting with a signal acquisition device. The second active electrode 22c is rectangular, triangular, diamond-shaped or circular, and the second active electrode 22c is used for acquiring an electro-oculogram signal. The second connection electrode 22b is rectangular, and the second connection electrode 22b is for connecting the second external electrode 22a and the second working electrode 22c.
The first external electrode 21a and the second external electrode 22a are opposed to each other in the first direction Z, and the first working electrode 21c and the second working electrode 22c are opposed to each other in the first direction Z. In the first direction Z, the pitch of the first external electrode 21a and the second external electrode 22a is smaller than the pitch of the first working electrode 21c and the second working electrode 22 c.
The third lead electrode 23 includes a third external electrode 23a, a third connection electrode 23b, and a third working electrode 23c. The third external electrode 23a is rectangular, triangular, diamond-shaped or circular, and the third external electrode 23a is used for connecting with a signal acquisition device. The third active electrode 23c is rectangular, triangular, diamond-shaped or circular, and the third active electrode 23c is used for acquiring an electro-oculogram signal. The third connection electrode 23b is rectangular, and the third connection electrode 23b is for connecting the third external electrode 23a and the third action electrode 23c.
Fig. 2 shows a schematic structural view of a second lead part 02 in the electro-oculogram signal sensor according to an embodiment of the present application.
As shown in fig. 2, the second lead part 02 may include a second flexible substrate 30 and a fourth lead electrode 40 positioned on a surface of the second flexible substrate 30.
The fourth lead electrode 40 includes a fourth external electrode 40a, a fourth connection electrode 40b, and a fourth working electrode 40c. The fourth external electrode 40a is rectangular, triangular, diamond-shaped or circular, and the fourth external electrode 40a is used for connecting with a signal acquisition device. The fourth active electrode 40c is rectangular, triangular, diamond-shaped or circular, and the fourth active electrode 40c is used for acquiring an electro-oculogram signal. The fourth connection electrode 40b is rectangular, and the fourth connection electrode 40b is for connecting the fourth external electrode 40a and the fourth working electrode 40c.
The fourth lead electrode 40 is arranged opposite to the third lead electrode 23 in a second direction perpendicular to the first direction Z.
In the application of the electro-oculogram signal sensor of the above embodiment, the first lead electrode 21, the second lead electrode 22, the third lead electrode 23 and the fourth lead electrode 40 are arranged based on the bipolar lead method of the standard electrode lead method. Among them, the first lead electrode 21 and the second lead electrode 22 may constitute a vertical lead for detecting a movement signal of an eyeball in a vertical (up and down) direction. The third lead electrode 23 and the fourth lead electrode 40 may constitute a horizontal lead for detecting a movement signal of an eyeball in a horizontal (left, right) direction. In addition, the vertical leads and the horizontal leads cooperate with each other, and a motion signal of the eyeball in the 45 ° diagonal (upper right, upper left, lower right, lower left) direction can also be detected. Thus, detection of eye movement in 8 directions, vertical (up, down), horizontal (left, right), and 45 ° diagonal (up right, up left, down right, down left) can be achieved. Blink signals are detected in the early stages of waking up and drowsiness and in the period of entering severe fatigue, and the sensor is found to realize the function of detecting the electrooculogram and has obvious distinguishing characteristics, and the obtained results are reliably verified. Therefore, the electro-oculogram signal sensor according to the embodiment can be used for electro-oculogram signal detection and resolution, and is beneficial to monitoring and preventing fatigue driving.
In one embodiment, as shown in fig. 3, the first lead part 01 may further include a first adhesive layer 50, and the first, second and third connection electrodes 21b, 22b and 23b may be located between the first flexible substrate 10 and the first adhesive layer 50. The first adhesive layer 50 includes a first hollowed-out portion 51 so that the first external electrode 21a, the second external electrode 22a, the third external electrode 23a, the first active electrode 21c, the second active electrode 22c and the third active electrode 23c are exposed to the first adhesive layer 50. The second lead part 02 may further include a second adhesive layer 60, and the fourth connection electrode 40b may be positioned between the second flexible substrate 30 and the second adhesive layer 60. The second adhesive layer 60 includes a second hollowed-out portion 61 so that the fourth external electrode 40a and the fourth working electrode 40c are exposed from the second adhesive layer 60.
In some examples, the first lead part 01 may further include a support frame 70, and the second lead part 02 may further include a support frame 70.
In some embodiments, the width d 1 of the first connection electrode 21b may be 2mm to 5mm.
In some embodiments, the width d 2 of the second connection electrode 22b may be 2mm to 5mm.
In some embodiments, the width d 3 of the third connection electrode 23b may be 2mm to 5mm.
In some embodiments, the width d 4 of the fourth connection electrode 40b may be 2mm to 5mm.
In some embodiments, the first active electrode 21c may be a circular electrode with a diameter of 5mm to 10 mm.
In some embodiments, the second active electrode 22c may be a circular electrode with a diameter of 5 mm-10 mm.
In some embodiments, the third active electrode 23c may be a circular electrode with a diameter of 5 mm-10 mm.
In some embodiments, the fourth active electrode 40c may be a circular electrode with a diameter of 5 mm-10 mm.
In some embodiments, the first external electrode 21a may be a rectangular electrode with a side length of 3mm to 8 mm.
In some embodiments, the second external electrode 22a may be a rectangular electrode with a side length of 3mm to 8 mm.
In some embodiments, the third external electrode 23a may be a rectangular electrode with a side length of 3mm to 8 mm.
In some embodiments, the fourth external electrode 40a may be a rectangular electrode with a side length of 3mm to 8 mm.
When the width of the connecting electrode, the shape and diameter of the acting electrode, and the shape and side length of the external electrode are within the above-described appropriate ranges, the lead electrode can ensure good conduction between the external electrode and the acting electrode while occupying a small area. Therefore, the electro-oculogram signal sensor has the advantages of simplicity, high integration level and low cost, and can also ensure the accuracy of electro-oculogram signal measurement. In the subsequent electro-oculogram signal measurement process, the electro-oculogram signal sensor with the electrode structure is found that the attaching position is not limited to the position of the eye orbit any more, even the lead electrodes are stretched to the forehead, the nose tip side cheek and the left and right temple positions, the electro-oculogram signal with more obvious characteristics can be detected, the limitation of the attaching position of the previous electrode is broken through, and the use is more flexible.
It can be appreciated that in the electro-oculogram signal sensor according to the embodiment of the present application, the length of the connection electrode may be adjusted according to actual use requirements. For example, when the attachment position is near the orbit of a person, since the orbit of the person is in the form of a quadrilateral conical bone cavity, the average width between the upper and lower orbits of the adult is about 4 to 5cm, the skeleton radian exists at the outer corners of the eye, the electro-oculogram signal sensor may be a rectangle with a side length of 110mm or less, the length of the connection electrode may be 20mm to 60mm, and the width of the connection electrode, the shape and diameter of the action electrode, and the shape and side length of the external electrode may be within the ranges of the above embodiments, respectively.
A second aspect of the application provides an electro-ocular signal sensor prepared in accordance with the method of any of the embodiments of the first aspect.
Examples
The present disclosure is more particularly described in the following examples that are intended as illustrations only, since various modifications and changes within the scope of the present disclosure will be apparent to those skilled in the art. Unless otherwise indicated, all parts, percentages, and ratios reported in the examples below are by weight, and all reagents used in the examples are commercially available or were obtained synthetically according to conventional methods and can be used directly without further treatment, as well as the instruments used in the examples.
Example 1
The electro-ocular signal sensor is prepared by the following steps:
and preparing a flexible substrate precursor solution with the mass concentration of 15% by taking PU as a solute and DMF as a solvent.
And uniformly injecting a solution and collecting fibers at the end of the metal roller through an electrostatic spinning process, and preparing a first flexible substrate, a second flexible substrate, a polymer initial substrate of the first bonding layer and a polymer initial substrate of the second bonding layer, wherein the first flexible substrate, the second flexible substrate and the polymer initial substrate of the second bonding layer are all 10 mu m in thickness and 110mm in size. In particular, the injector is adjusted to a suitable height, set at a distance of 19cm from the fiber-receiving metal cylinder, to ensure adequate drying path of the jet. After the jet needle is regulated to be leveled with the central line of the fiber receiving metal cylinder, setting relevant spinning parameters, namely, the push injection speed of the injector is 0.2mm/min, the translation speed of the injector is 200mm/min, and the receiving speed of the fiber receiving metal cylinder is 60mm/min. After the start, the positive voltage meter and the negative voltage meter are opened, and +10kV and-0.85 kV voltages are respectively applied. The spinning time is about 1 h.
And respectively fixing the first flexible substrate and the second flexible substrate on a silicon wafer, and uniformly plating a 200nm metal Pt film on the PU substrate by a magnetron sputtering method and a special hard mask plate to finish the preparation of the electrode, thereby obtaining a first lead part and a second lead part. The eyebox of a human is similar to a quadrilateral conical bone cavity, the average width between the upper eyebox and the lower eyebox of an adult is about 4-5 cm, skeleton radian exists at the outer eyebox, and therefore each Pt electrode (namely a first lead electrode-a fourth lead electrode) consists of three parts, namely (1) a disc-shaped electrode with the diameter of 8mm, which is used as an action electrode to capture an electro-oculogram signal, (2) a square external electrode with the side length of 5mm, which is used for connecting a lead wire to a signal acquisition plate, and (3) a connecting electrode used for connecting the action electrode and the external electrode, wherein the length of a vertical lead part is 60mm, the length of a horizontal lead part is 26mm, and the line width is 3mm. The electrode layout of the electro-oculogram signal sensor is shown in fig. 4.
And (3) carrying out hollowed-out treatment on the polymer initial substrate of the first bonding layer and the polymer initial substrate of the second bonding layer according to the illustration in fig. 3 to obtain the polymer substrate of the first bonding layer and the polymer substrate of the second bonding layer. The polymer substrate of the first adhesive layer and the polymer substrate of the second adhesive layer were treated with a PDMS/n-hexane solution having a concentration of 20%, and the first adhesive layer and the second adhesive layer were disposed in the first lead part and the second lead part as shown in fig. 3, to prepare an electro-oculogram signal sensor.
And (3) characterizing the edge position and the center position of the first flexible substrate by using an optical microscope, wherein the obtained optical microscope images are respectively shown in fig. 5-6. The first flexible substrate was characterized using a metallographic microscope at different magnification (5X, scale: 100. Mu.m, 10X, scale: 50. Mu.m, 20X, scale: 20. Mu.m, 50X, scale: 10 μm), and the resulting metallographic microscope images were shown in FIGS. 7 to 10, respectively. Scanning Electron Microscope (SEM) images of the first flexible substrate were taken, which are shown in (a) and (b) of fig. 11 at different magnifications (500 x, 1000 x), respectively. As shown in fig. 11 (c), the SEM image at 1000 times magnification was processed, and the diameter of the fiber in the first flexible substrate was tested, which was 2.017 to 2.489 μm. According to the test results shown in fig. 5 to 11, the flexible substrate prepared by the method of the present application has small and uniform fiber diameter and good air permeability.
Leads (copper fiber wires) are led out through external electrodes and fixed by silver paste. And finally, coating PDMS on the silver paste to complete the encapsulation of the device. An electrooculogram signal sensor is attached to the face of a subject as shown in fig. 12. The test is performed by building an Open BCI test platform, which can be shown in fig. 13. Eye movement is detected in 8 directions of vertical (up, down), horizontal (left, right) and 45 DEG diagonal (up right, up left, down right, down left), and the obtained eye movement test results can be seen in fig. 14 to 17. The blink status of the subjects was detected at the early stages of wakefulness, drowsiness and the stage of entering severe fatigue, and the test results obtained can be seen in fig. 18 to 19.
Fig. 14 shows an EOG signal of vertical movement of an eyeball detected by the electro-ocular signal sensor, where fig. 14 (a) shows the EOG signal of an upward glance and fig. 14 (b) shows the EOG signal of a downward glance. Fig. 15 shows an EOG signal of the eye horizontal movement detected by the electro-ocular signal sensor, in which fig. 15 (a) shows the EOG signal of the right glance and fig. 15 (b) shows the EOG signal of the left glance. Fig. 16 shows EOG signals of eye diagonal movements detected by the electro-oculogram signal sensor, in which fig. 16 (a) shows an EOG signal of an upward right glance, fig. 16 (b) shows an EOG signal of an upward left glance, fig. 16 (c) shows an EOG signal of a downward right glance, and fig. 16 (d) shows an EOG signal of a downward left glance.
20 Sets of data are acquired for each eye movement direction, and the respective slope characteristics are calculated to obtain a scatter plot of the eye movement slope characteristics as shown in fig. 17. Wherein the horizontal axis M H represents the slope characteristics of the horizontal eye movement signal and the vertical axis M V represents the slope characteristics of the vertical eye movement signal. As can be seen from fig. 17, the slope characteristics of 8 eye movements can be clearly distinguished from the signal detected by the electro-ocular signal sensor, without the degree of overlap.
Fig. 18 shows the blink signal detected by the electrical ocular signal sensor. Wherein fig. 18 (a) shows an unintentional blink signal, fig. 18 (b) shows a conscious signal, and fig. 18 (c) shows a half blink signal. Fig. 19 shows a time-domain plot of a single blink signal in an unconscious state, a conscious state, and a semi-blink state. As can be seen from fig. 19, the signal peak of unintentional blinks is between 100 and 150 μv, and the peak of intentional blinks and half blinks are both between 300 and 350 μv. At the same time, the duration of a single blink increases significantly after entering the period of severe fatigue.
According to the test results, the electro-oculogram signal sensor can realize an electro-oculogram detection function and has obvious distinguishing characteristics, and the obtained results are reliably verified. Therefore, the EOG electro-oculogram signal sensor based on electrostatic spinning can be used for electro-oculogram signal detection and resolution, and is beneficial to monitoring and preventing fatigue driving.
In addition, the research of the electro-oculogram signal sensor in the embodiment of the application relates to the cross fusion direction of multiple subjects such as microelectronics, biomedicine, material physics and the like, and the prepared novel electro-oculogram signal sensor can monitor in real time and high efficiently, can discover abnormality in the early stage of drowsiness, and provides a more natural and convenient brand-new hardware design thought for fatigue driving identification based on electro-oculogram. The electro-oculogram signal sensor provided by the embodiment of the application has good biocompatibility, flexibility and stability, provides reliable technical support for non-inductive electro-oculogram signal detection, also injects new vitality into the fields of microelectronic devices, medical diagnosis, health monitoring and the like for EOG technology, and shows the potential of diversified application.
Example 2
And preparing a flexible substrate precursor solution with the mass concentration of 5% by taking PU as a solute and DMF as a solvent. And (3) adjusting electrostatic spinning process parameters to prepare the flexible substrate with the thickness of 50nm and the size of 110 mm.
The flexible substrate of example 2 was tested for fiber diameter, and the test results were 0.048-0.050 μm.
Example 3
And preparing a flexible substrate precursor solution with mass concentration of 18% by taking PU as a solute and DMF as a solvent.
And (3) adjusting electrostatic spinning process parameters to prepare the flexible substrate with the thickness of 5 mu m and the size of 110 mm.
The flexible substrate of example 3 was tested for fiber diameter, and the test results were 0.388-1.315 μm.
Example 4
And preparing a flexible substrate precursor solution with the mass concentration of 30% by taking PU as a solute and DMF as a solvent. And (3) adjusting electrostatic spinning process parameters to prepare the flexible substrate with the thickness of 8 mu m and the size of 110 mm.
The flexible substrate of example 4 was tested for fiber diameter, and the test results were 0.386-0.776 μm.
The test results of examples 2 to 4 show that the flexible substrate precursor solution is spun by an electrostatic spinning process to obtain a flexible substrate with proper thickness. The flexible substrate with proper thickness is light and thin, has smaller fiber diameter, and can meet the air permeability requirement of the electro-oculogram signal sensor. Thus, the non-inductive wearing of the electro-oculogram signal sensor is facilitated.
While the application has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the application. Therefore, the protection scope of the application is subject to the protection scope of the claims.
Claims (9)
1. A method for preparing an electro-ocular signal sensor, comprising:
providing a flexible substrate precursor solution comprising a polymer and an organic solvent;
spinning the precursor solution of the flexible substrate through an electrostatic spinning process to obtain a flexible substrate with the thickness of 50 nm-10 mu m;
Arranging a lead electrode with the thickness of 100-500 nm on the surface of the flexible substrate to obtain an electro-oculogram signal sensor;
The flexible substrate includes a first flexible substrate;
the method for arranging the lead electrode on the surface of the flexible substrate comprises the steps of arranging a first lead electrode and a second lead electrode on the surface of the first flexible substrate;
The first lead electrode comprises a first external electrode, a first connecting electrode and a first acting electrode, wherein the first external electrode is rectangular, triangular, diamond-shaped or circular, the first external electrode is used for being connected with the signal acquisition device, the first acting electrode is rectangular, triangular, diamond-shaped or circular, the first acting electrode is used for acquiring an electro-oculogram signal, the first connecting electrode is rectangular, and the first connecting electrode is used for connecting the first external electrode and the first acting electrode;
The second lead electrode comprises a second external electrode, a second connecting electrode and a second acting electrode, wherein the second external electrode is rectangular, triangular, diamond-shaped or circular, and the second external electrode is used for being connected with the signal acquisition device; the second action electrode is rectangular, triangular, diamond-shaped or circular, and is used for collecting an electro-oculogram signal, the second connection electrode is rectangular, and the second connection electrode is used for connecting the second external electrode and the second action electrode;
the first external electrode and the second external electrode are opposite along a first direction, the first action electrode and the second action electrode are opposite along the first direction, and the distance between the first external electrode and the second external electrode is smaller than the distance between the first action electrode and the second action electrode in the first direction.
2. The method of claim 1, wherein the providing a flexible substrate precursor solution comprises:
And dissolving the polymer in the organic solvent to obtain a flexible substrate precursor solution with the mass concentration of 5% -30%.
3. The method of claim 2, wherein the polymer comprises one or more of polyurethane, polyethylene terephthalate, polyimide;
The organic solvent comprises one or more of N, N-dimethylacetamide, N-dimethylformamide and chloroform.
4. A method according to any of claims 1-3, wherein the flexible substrate comprises polymer fibres having a diameter of 50 nm-10 μm.
5. The method according to claim 1, wherein the disposing the lead electrode with a thickness of 100nm to 500nm on the surface of the flexible substrate comprises:
And depositing a metal film on the surface of the flexible substrate according to a preset electrode layout to form a lead electrode with the thickness of 100-500 nm.
6. The method of claim 1, wherein after disposing a lead electrode on the surface of the flexible substrate, the method further comprises:
an adhesive layer with a hollowed-out portion is arranged on one side of the flexible substrate, which faces the lead electrode, wherein the hollowed-out portion exposes a part of the lead electrode.
7. The method of claim 6, wherein the adhesive layer comprises a polymer substrate and a pressure sensitive layer on a surface of the polymer substrate.
8. The method of claim 1, wherein the flexible substrate further comprises a second flexible substrate, wherein the disposing of the lead electrode on the surface of the flexible substrate further comprises disposing a third lead electrode on the surface of the first flexible substrate, and disposing a fourth lead electrode on the surface of the second flexible substrate;
The third lead electrode comprises a third external electrode, a third connecting electrode and a third action electrode, wherein the third external electrode is rectangular, triangular, diamond-shaped or circular, the third external electrode is used for being connected with the signal acquisition device, the third action electrode is rectangular, triangular, diamond-shaped or circular, the third action electrode is used for acquiring an electro-oculogram signal, the third connecting electrode is rectangular, and the third connecting electrode is used for connecting the third external electrode and the third action electrode;
The fourth lead electrode comprises a fourth external electrode, a fourth connecting electrode and a fourth acting electrode, wherein the fourth external electrode is rectangular, triangular, diamond-shaped or circular, the fourth external electrode is used for being connected with the signal acquisition device, the fourth acting electrode is rectangular, triangular, diamond-shaped or circular, the fourth acting electrode is used for acquiring an electro-oculogram signal, the fourth connecting electrode is rectangular, and the fourth connecting electrode is used for connecting the fourth external electrode and the fourth acting electrode;
The fourth lead electrode is arranged opposite to the third lead electrode along a second direction, and the second direction is perpendicular to the first direction.
9. An electro-ocular signal sensor prepared according to the method of any one of claims 1-8.
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