CN119607077A - Preparation method of traditional Chinese medicine acupoint patch for treating children's allergic dermatitis - Google Patents
Preparation method of traditional Chinese medicine acupoint patch for treating children's allergic dermatitis Download PDFInfo
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Abstract
The invention belongs to the crossing field of biological medicine and material science, and in particular relates to traditional Chinese medicine acupoint application for treating allergic dermatitis in children and a preparation method thereof. The invention combines the prepared mesoporous hollow SiO 2 microsphere with the traditional Chinese medicine liquid for treating allergic dermatitis, then coats the traditional Chinese medicine liquid on a traditional Chinese medicine patch, covers the prepared ammonium bicarbonate composite resin on the traditional Chinese medicine paste, dries the traditional Chinese medicine liquid at room temperature, and cures the traditional Chinese medicine liquid by ultraviolet rays. The mesoporous hollow SiO 2 microsphere can be used as a traditional Chinese medicine carrier, so that the medicine loading capacity is improved, and the medicine volatilization is reduced. In addition, the medicine on the traditional Chinese medicine patch is covered by the resin compounded by ammonium bicarbonate, so that the volatilization of the medicine is further reduced, the ammonium bicarbonate can be gasified by the temperature of a human body to generate holes, the medicine can permeate out, and the traditional Chinese medicine patch is obtained through the process, and has large medicine loading and strong volatility resistance.
Description
Technical Field
The invention belongs to the crossing field of biological medicine and material science, and in particular relates to a preparation method of traditional Chinese medicine acupoint application for treating allergic dermatitis of children.
Background
Allergic dermatitis in children is a rather common skin disorder in the childhood population, and the symptoms often exhibit diversified characteristics, and are generally represented by a series of symptoms such as redness of skin, obvious swelling, local heating, obvious pain, and intolerable itching. The allergic dermatitis of children is complicated and various. For example, bacterial attack, fungal infection, allergen exposure, various external stimuli, etc. may be factors that lead to allergic dermatitis in children.
In terms of treatment, the methods vary from one disease to another. Generally, oral and topical medications are contemplated. Clinically, various symptoms of skin inflammation in the acute stage are usually treated by the combination of oral medicines and external medicines, and local or systemic inflammatory reactions of patients are relieved. Oral drugs can exert their therapeutic effects from the systemic system of the human body. However, both antibiotics, hormones and immunosuppressants have certain side effects, and long-term use may have a series of adverse effects. Thus, patients with a relatively low degree of pediatric allergic dermatitis tend to prefer topical medications for treatment. For small amounts of allergic dermatitis, the topical drug may be directly applied to the inflammatory surface. For allergic dermatitis with large area, the medicine is not required to be coated with large area, and the medicine can be coated on the acupoints of human body to obtain faster medicine effect. However, the external coating medicine still has inconvenience in terms of operation, wherein the external coating medicine easily contaminates clothes and bedding when being on the surface of skin and is not easy to exert the effect for a long time as a key point puzzled for the application thereof.
Chinese patent (CN 103623104A) discloses a Chinese medicinal patch for treating skin superficial inflammation and its preparation method. The obtained Chinese medicinal liquid is injected onto the patch to obtain Chinese medicinal patch. The method can prevent the liquid medicine from exuding and contaminating clothes. However, the medicine liquid is directly injected onto the medicine patch, so that the medicine is relatively fast in volatilization and difficult to store for a long time, the production, transportation and storage costs of the corresponding traditional Chinese medicine preparation are increased directly, the further market popularization of the traditional Chinese medicine preparation is limited, and the new possibility of improving the external medicine of the skin is limited for more patients. Meanwhile, the operation of directly injecting the liquid medicine onto the medicine patch has lower medicine loading capacity, and has a technical innovation space for further improving the medicine loading capacity and the medicine effect.
Disclosure of Invention
The invention provides a preparation method of traditional Chinese medicine acupoint application for treating allergic dermatitis of children, aiming at overcoming the defects of the prior art. The traditional Chinese medicine formula for clearing heat and detoxicating, inhibiting bacteria and promoting blood circulation is adopted to achieve the effects of diminishing inflammation and relieving itching and promote recovery of skin tissues. The mesoporous hollow SiO 2 microsphere can be used as a traditional Chinese medicine carrier, so that the medicine loading capacity is improved, and the medicine volatilization is reduced. In addition, the medicine stuck on the traditional Chinese medicine is covered by the resin compounded by ammonium bicarbonate, so that the volatilization of the medicine is further reduced, and the ammonium bicarbonate is gasified at the temperature of 30-60 ℃ to generate holes, so that the medicine can permeate out.
The technical scheme adopted for solving the technical problems is as follows:
A preparation method of traditional Chinese medicine acupoint application for treating allergic dermatitis of children, which comprises the following steps:
s1, mixing and grinding nux vomica, coptis chinensis, radix sophorae flavescentis, cortex phellodendri, radix angelicae, rheum officinale and safflower, soaking the mixture in absolute ethyl alcohol for 24-72 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
S2, mixing 1-5 parts by mass of mesoporous hollow SiO 2 microspheres with 50-200 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 3-6 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 5-30 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion liquid;
S3, injecting the composite dispersion liquid in the step S2 to the medicine patch in an amount of 0.1-1 ml/cm 2;
s4, injecting ammonium bicarbonate compound resin with the dosage of 0.04-0.1 ml/cm 2 on the traditional Chinese medicine patch in the step S3, airing at room temperature, and curing the coating for 20-40S by using 400mJ/cm 2 ultraviolet rays;
as a further preference of the preparation method of the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children.
Preferably, the addition amounts of the nux vomica, the coptis chinensis, the kuh-seng, the phellodendron bark, the angelica dahurica, the rheum officinale, the safflower and the absolute ethyl alcohol in the step S1 are 5-7 parts by mass, 2-4 parts by mass, 2-3 parts by mass, 5-7 parts by mass and 200-500 parts by mass respectively.
Preferably, the mesoporous hollow SiO 2 microsphere in the step S2 has a diameter size ranging from 50nm to 150nm.
The small diameter of the mesoporous hollow SiO 2 microspheres can lead to a centrifugation process, and a large number of mesoporous hollow SiO 2 microspheres can not be centrifuged out and still remain in the liquid. The mesoporous hollow SiO 2 microsphere has too large diameter, which can cause the mesoporous hollow SiO 2 microsphere to be precipitated in the traditional Chinese medicine liquid and be difficult to disperse uniformly.
Preferably, the preparation method of the ammonium bicarbonate composite resin in the step S4 comprises the steps of dissolving ammonium bicarbonate in deionized water, then sequentially adding absolute ethyl alcohol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone, and stirring under the condition of light shielding.
Preferably, the addition amounts of ammonium bicarbonate, deionized water, absolute ethyl alcohol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are respectively 0.2-0.5 part by mass, 5-20 parts by mass, 10-20 parts by mass, 1-2 parts by mass and 0.2-0.5 part by mass.
The addition of less than 0.2 parts by mass of ammonium bicarbonate results in insufficient pores in the coating layer after the ammonium bicarbonate is gasified, resulting in difficulty in releasing the Chinese medicinal liquid.
The traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is prepared according to the preparation method.
Semen Strychni has effects of dredging collaterals, relieving pain, resolving hard mass and relieving swelling.
Huang Lian can clear heat and dry dampness, purge fire and detoxify.
Radix Sophorae Flavescentis has effects of clearing heat, eliminating dampness, killing parasites and promoting urination.
Cortex Phellodendri has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore.
Radix Angelicae Dahuricae has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, relieving stuffy nose, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus.
Rhubarb has the effects of purging pathogenic accumulation, clearing heat, purging fire, cooling blood, removing toxin, removing blood stasis, dredging channels and the like.
Safflower has the functions of activating blood circulation, dredging channels, dispersing blood stasis and relieving pain.
Compared with the prior art, the invention has the beneficial effects that:
(1) Compared with directly injecting the medicine onto the traditional Chinese medicine patch, the medicine can be leveled, so that the medicine loading capacity is reduced, and the prepared mesoporous hollow SiO 2 microsphere can enable the traditional Chinese medicine liquid to enter the cavities of the particles, and the mesoporous hollow SiO 2 microsphere can enable the medicine liquid to be fixed in the cavities, so that the medicine loading capacity is increased. In addition, the mesoporous hollow SiO 2 microsphere shell can reduce the volatilization of the liquid medicine.
(2) Compared with directly injecting the liquid medicine onto the traditional Chinese medicine patch, the invention injects the traditional Chinese medicine liquid mixed by the mesoporous hollow SiO 2 microsphere onto the traditional Chinese medicine patch, then covers a layer of ammonium bicarbonate compound resin on the traditional Chinese medicine patch, and can have good sealing effect through ultraviolet curing. Can further reduce the volatilization of the traditional Chinese medicine liquid.
(3) In the present invention, the ammonium bicarbonate in the ammonium bicarbonate composite resin is hardly decomposed at room temperature, and gas is generated by decomposition at a temperature above 30 ℃, so that pores are generated in the cured resin coating. The temperature of the human body just meets the condition, and the traditional Chinese medicine is stuck on the human body to decompose the ammonium bicarbonate, so that holes are formed in the covered resin layer, and the liquid medicine can permeate out.
Drawings
FIG. 1 is a transmission electron micrograph of mesoporous hollow SiO 2 microspheres prepared in example 1;
FIG. 2 is a scanning electron microscope photograph of mesoporous hollow SiO 2 microspheres synthesized in example 4;
FIG. 3 is an N 2 adsorption-desorption isotherm of the mesoporous hollow SiO 2 microsphere powder synthesized in example 4;
FIG. 4 is a transmission electron micrograph of the hollow SiO 2 microsphere mixed with the mesoporous in example 4;
FIGS. 5 (a) and 5 (b) are, respectively, a scanning electron micrograph of the ammonium bicarbonate composite resin prepared in example 2 and a scanning electron micrograph after heating at 36℃for 30 min;
FIG. 6 is a scanning electron micrograph of the ammonium bicarbonate composite resin prepared in comparative example 2 after heating at 36℃for 30min;
FIG. 7 is a graph showing the volatilization curves of the traditional Chinese medicine patches prepared in comparative example 1 and examples 1 to 5;
fig. 8 is a bar graph of drug loading of the traditional Chinese medicine patches prepared in comparative example 1 and examples 1-5.
Detailed Description
The present invention will be further described with reference to examples and comparative examples.
Example 1
The embodiment provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof, and the method specifically comprises the following steps:
S1, mixing and grinding 5 parts by mass of nux vomica, 5 parts by mass of coptis chinensis, 5 parts by mass of radix sophorae flavescentis, 2 parts by mass of amur corktree bark, 2 parts by mass of dahurian angelica root, 5 parts by mass of rheum officinale and 5 parts by mass of safflower, soaking in 200 parts by mass of absolute ethyl alcohol for 24 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
s2, mixing 1 part by mass of mesoporous hollow SiO 2 microspheres with 50 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 3 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 5 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion;
S3, injecting the mixed liquid medicine in the step S2 to a medicine patch according to the dosage of 0.1ml/cm 2;
S4, injecting ammonium bicarbonate compounded resin on the liquid medicine in the step S3 at the dosage of 0.04ml/cm 2, airing at room temperature, and then curing the coating for 20S through ultraviolet rays of 400mJ/cm 2;
the preparation method of the ammonium bicarbonate composite resin in the step S4 specifically comprises the following steps of dissolving 0.2 part by mass of ammonium bicarbonate in 5 parts by mass of deionized water, then sequentially adding 10 parts by mass of absolute ethyl alcohol, 1 part by mass of pentaerythritol triacrylate and 0.2 part by mass of hydroxycyclohexyl phenyl ketone, and stirring under a light-shielding condition.
According to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Example 2
The embodiment provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof, and the method specifically comprises the following steps:
S1, mixing and grinding 7 parts by mass of nux vomica, 7 parts by mass of coptis chinensis, 7 parts by mass of radix sophorae flavescentis, 4 parts by mass of phellodendron amurense, 3 parts by mass of radix angelicae, 7 parts by mass of rheum officinale and 7 parts by mass of safflower, soaking in 500 parts by mass of absolute ethyl alcohol for 72 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
S2, mixing 5 parts by mass of mesoporous hollow SiO 2 microspheres with 200 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 6 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 30 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain a composite dispersion liquid
S3, taking the mixed liquid medicine obtained in the step S2, and injecting the mixed liquid medicine into the medicine patch at the dosage of 1ml/cm 2;
S4, injecting ammonium bicarbonate compounded resin on the liquid medicine in the step S3 at the dosage of 0.1ml/cm 2, airing at room temperature, and then curing the coating for 20S through ultraviolet rays of 400mJ/cm 2;
The preparation method of the ammonium bicarbonate composite resin in the step S4 specifically comprises the following steps of dissolving 0.5 part by mass of ammonium bicarbonate in 20 parts by mass of deionized water, then sequentially adding 200 parts by mass of absolute ethyl alcohol, 2 parts by mass of pentaerythritol triacrylate and 0.5 part by mass of hydroxycyclohexyl phenyl ketone, and stirring under a light-shielding condition.
According to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Example 3
The embodiment provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof, and the method specifically comprises the following steps:
S1, mixing and grinding 6 parts by mass of nux vomica, 6 parts by mass of coptis chinensis, 6 parts by mass of radix sophorae flavescentis, 3 parts by mass of phellodendron amurense, 3 parts by mass of radix angelicae, 6 parts by mass of rheum officinale and 6 parts by mass of safflower, soaking in 300 parts by mass of absolute ethyl alcohol for 36 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
S2, mixing 3 parts by mass of mesoporous hollow SiO 2 microspheres with 100 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 4 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 15 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion;
S3, injecting the mixed liquid medicine in the step S2 to a medicine patch according to the dosage of 0.4ml/cm 2;
S4, injecting ammonium bicarbonate compounded resin on the liquid medicine in the step S3 at the dosage of 0.08ml/cm 2, airing at room temperature, and then curing the coating for 20S through ultraviolet rays of 400mJ/cm 2;
The preparation method of the ammonium bicarbonate composite resin in the step S4 specifically comprises the following steps of dissolving 0.3 part by mass of ammonium bicarbonate in 10 parts by mass of deionized water, then sequentially adding 15 parts by mass of absolute ethyl alcohol, 1.5 parts by mass of pentaerythritol triacrylate and 0.3 part by mass of hydroxycyclohexyl phenyl ketone, and stirring under a light-shielding condition.
According to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Example 4
The embodiment provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof, and the method specifically comprises the following steps:
S1, mixing and grinding 6 parts by mass of nux vomica, 6 parts by mass of coptis chinensis, 6 parts by mass of radix sophorae flavescentis, 3 parts by mass of phellodendron amurense, 3 parts by mass of radix angelicae, 6 parts by mass of rheum officinale and 6 parts by mass of safflower, soaking in 300 parts by mass of absolute ethyl alcohol for 36 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
s2, mixing 1 part by mass of mesoporous hollow SiO 2 microspheres with 50 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 3 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 5 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion;
S3, injecting the mixed liquid medicine in the step S2 to a medicine patch according to the dosage of 0.5ml/cm 2;
S4, injecting ammonium bicarbonate compounded resin on the liquid medicine in the step S3 at the dosage of 0.06ml/cm 2, airing at room temperature, and then curing the coating for 20S through ultraviolet rays of 400mJ/cm 2.
The preparation method of the ammonium bicarbonate composite resin in the step S4 specifically comprises the following steps of dissolving 0.2 part by mass of ammonium bicarbonate in5 parts by mass of deionized water, then sequentially adding 12 parts by mass of absolute ethyl alcohol, 1.5 parts by mass of pentaerythritol triacrylate and 0.3 part by mass of hydroxycyclohexyl phenyl ketone, and stirring under a light-shielding condition.
According to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Example 5
The embodiment provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof, and the method specifically comprises the following steps:
S1, mixing and grinding 5 parts by mass of nux vomica, 5 parts by mass of coptis chinensis, 5 parts by mass of radix sophorae flavescentis, 2 parts by mass of amur corktree bark, 2 parts by mass of dahurian angelica root, 5 parts by mass of rheum officinale and 5 parts by mass of safflower, soaking in 200 parts by mass of absolute ethyl alcohol for 24 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
s2, mixing 1 part by mass of mesoporous hollow SiO 2 microspheres with 50 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 3 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 5 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion;
S3, injecting the mixed liquid medicine in the step S2 to a medicine patch according to the dosage of 0.1ml/cm 2;
S4, injecting ammonium bicarbonate compounded resin on the liquid medicine in the step S3 at the dosage of 0.04ml/cm 2, airing at room temperature, and then curing the coating for 20S through ultraviolet rays of 400mJ/cm 2;
The preparation method of the ammonium bicarbonate composite resin in the step S4 specifically comprises the following steps of dissolving 0.2 part by mass of ammonium bicarbonate in 5 parts by mass of deionized water, then sequentially adding 10 parts by mass of absolute ethyl alcohol, 1 part by mass of pentaerythritol triacrylate and 0.2 part by mass of hydroxycyclohexyl phenyl ketone, and stirring under a light-shielding condition.
According to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Comparative example 1
The comparative example provides a preparation method for directly injecting Chinese medicinal liquid on a Chinese medicinal patch, which specifically comprises the following steps:
S1, mixing and grinding 5 parts by mass of nux vomica, 5 parts by mass of coptis chinensis, 5 parts by mass of radix sophorae flavescentis, 2 parts by mass of amur corktree bark, 2 parts by mass of dahurian angelica root, 5 parts by mass of rheum officinale and 5 parts by mass of safflower, soaking in 200 parts by mass of absolute ethyl alcohol for 24 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
S2, injecting the traditional Chinese medicine liquid in the step S1 to a medicine patch in an amount of 0.1ml/cm 2;
according to the mode, the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is obtained.
Comparative example 2
The present comparative example provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof. The ammonium bicarbonate was added in an amount of 1 part by mass, and the other parts were the same as in example 2.
Comparative example 3
The present comparative example provides a traditional Chinese medicine acupoint application for treating allergic dermatitis of children and a preparation method thereof. The size of the mesoporous hollow SiO 2 microsphere in this comparative example ranges from 200 to 300nm, and the other parts are the same as in example 1.
In comparative example 3, mesoporous hollow SiO 2 microspheres were precipitated in the Chinese medicinal liquid and were difficult to disperse.
FIG. 1 is a transmission electron micrograph of mesoporous hollow SiO 2 microspheres prepared in example 1. The diameter size of the synthesized mesoporous hollow SiO 2 microsphere is 50-150 nm, and the hollow SiO 2 microsphere has a large inner cavity structure and can bear Chinese medicinal liquid.
FIG. 2 is a scanning electron microscope photograph of mesoporous hollow SiO 2 microspheres synthesized in example 4. This means that the medicine liquid can enter and exit the hollow SiO 2 microsphere through the mesoporous, and can play a good role in absorption and release.
FIG. 3 is an N 2 adsorption-desorption isotherm of mesoporous hollow SiO 2 microsphere powder synthesized in example 4. It can be seen that the specific surface area is relatively high, which is caused by the mesoporous and hollow structure of the SiO 2 microsphere.
FIG. 4 is a transmission electron micrograph of the traditional Chinese medicine of example 4 after mixing mesoporous hollow SiO 2 microspheres. The picture shows that after the mesoporous hollow SiO 2 microsphere is mixed with the traditional Chinese medicine liquid, the medicine enters into the inner cavity of the microsphere.
Fig. 5 (a) and 5 (b) are a scanning electron micrograph of the ammonium bicarbonate composite resin prepared in example 2 and a scanning electron micrograph after heating at 36 ℃ for 30min, respectively. Fig. 5 (a) illustrates that the surface of the ammonium bicarbonate compounded resin is very dense and has good sealing performance, and after 36 ℃ heating, many pores appear on the surface of fig. 5 (b), so that the Chinese medicinal liquid can permeate out.
Fig. 6 is a scanning electron micrograph of the ammonium bicarbonate composite resin prepared in comparative example 2 after heating at 36 ℃ for 30min, and it can be seen that the pores on the surface of the coating are small, which means that the ammonium bicarbonate addition amount is 0.1, which is insufficient to form enough pores, resulting in difficulty in releasing the drug.
Fig. 7 is a graph showing the drug volatilization curves of the traditional Chinese medicine patches prepared in comparative example 1 and examples 1 to 5. It is evident that the liquid medicine in the comparative example volatilized fast, whereas the liquid medicine in the example volatilized slowly.
Fig. 8 is a bar graph of drug loading of the traditional Chinese medicine patches prepared in comparative example 1 and examples 1-5. It can be seen that the drug loading of examples 1-5 is higher than that of comparative example, which demonstrates that the traditional Chinese medicine patch prepared by the invention improves the drug loading.
From the experimental results of comparative examples 1-2 and examples 1-5, it can be seen that the invention prepares a traditional Chinese medicine acupoint application for treating allergic dermatitis in children.
Those skilled in the art will appreciate that the foregoing is merely a few, but not all, embodiments of the invention. It should be noted that many variations and modifications can be made by those skilled in the art, and all variations and modifications which do not depart from the scope of the invention as defined in the appended claims are intended to be protected.
Claims (6)
1. The preparation method of the traditional Chinese medicine acupoint application for treating the allergic dermatitis of children is characterized by comprising the following steps of:
s1, mixing and grinding nux vomica, coptis chinensis, radix sophorae flavescentis, cortex phellodendri, radix angelicae, rheum officinale and safflower, soaking the mixture in absolute ethyl alcohol for 24-72 hours, and centrifuging to obtain a traditional Chinese medicine liquid;
S2, mixing 1-5 parts by mass of mesoporous hollow SiO 2 microspheres with 50-200 parts by mass of the traditional Chinese medicine liquid in the step S1, stirring for 3-6 hours, centrifuging to obtain traditional Chinese medicine-loaded mesoporous hollow SiO 2 microspheres, adding 5-30 parts by mass of the traditional Chinese medicine liquid in the step S1 into the mesoporous hollow SiO 2 microspheres, and carrying out ultrasonic treatment for 3 minutes to obtain composite dispersion liquid;
S3, injecting the composite dispersion liquid in the step S2 to the medicine patch in an amount of 0.1-1 ml/cm 2;
S4, injecting ammonium bicarbonate compound resin with the dosage of 0.04-0.1 ml/cm 2 on the traditional Chinese medicine patch in the step S3, airing at room temperature, and curing the coating for 20-40S by using 400mJ/cm 2 ultraviolet rays.
2. The method for preparing the traditional Chinese medicine acupoint application for treating allergic dermatitis in children according to claim 1, wherein the addition amount of nux vomica, coptis chinensis, radix sophorae flavescentis, cortex phellodendri, radix angelicae dahuricae, rheum officinale, safflower and absolute ethyl alcohol in the step S1 is 5-7 parts by mass, 2-4 parts by mass, 2-3 parts by mass, 5-7 parts by mass and 5-7 parts by mass, 200-500 parts by mass respectively.
3. The method for preparing the Chinese medicinal acupoint application for treating allergic dermatitis in children according to claim 1, wherein the mesoporous hollow SiO 2 microsphere in the step S2 has a diameter size ranging from 50nm to 150nm.
4. The method for preparing the traditional Chinese medicine acupoint application for treating allergic dermatitis of children as claimed in claim 1, wherein the preparation method of the ammonium bicarbonate compound resin in the step S4 is characterized in that ammonium bicarbonate is dissolved in deionized water, then absolute ethyl alcohol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are sequentially added, and stirring is carried out under a light-proof condition.
5. The preparation method of the traditional Chinese medicine acupoint application for treating allergic dermatitis in children, which is characterized in that the addition amount of ammonium bicarbonate, deionized water, absolute ethyl alcohol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone is 0.2-0.5 part by mass, 5-20 parts by mass, 10-20 parts by mass, 1-2 parts by mass and 0.2-0.5 part by mass respectively.
6. A traditional Chinese medicine acupoint application for treating allergic dermatitis in children, which is prepared by the preparation method of any one of claims 1-5.
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