CN119524241A

CN119524241A - Control method, controller, purification equipment and system for blood purification treatment mode

Info

Publication number: CN119524241A
Application number: CN202411563394.1A
Authority: CN
Inventors: 燕兆; 孙晨琳; 任高波; 唐文普; 梁瑾; 郑加新; 唐明云
Original assignee: Guangdong Baolaite Blood Purification Technology Co ltd
Current assignee: Guangdong Baolaite Blood Purification Technology Co ltd
Priority date: 2024-11-04
Filing date: 2024-11-04
Publication date: 2025-02-28

Abstract

The embodiments of the present invention provide a control method, controller, purification equipment and system for a blood purification treatment mode, which solves the technical problems in the prior art that the number of treatment modes integrated in the blood purification equipment is small, the operation is relatively cumbersome, and the convenience is poor. The present invention provides a control method for a blood purification treatment mode, which can combine liquid circuits corresponding to multiple pipeline components by regulating the start or disconnection of multiple pumps, the start or disconnection of multiple functional devices, and the conduction or cutoff of multiple connecting pipelines. The liquid circuits corresponding to multiple pipeline components can correspond to multiple treatment modes, thereby realizing the integration of more treatment modes on a blood purification device, and improving the integration and convenience of use of the blood purification device.

Description

Control method, controller, purifying equipment and system for blood purifying treatment mode

Technical Field

The invention relates to the technical field of medical equipment, in particular to a control method, a controller, purifying equipment and a system of a blood purifying treatment mode.

Background

The blood purifying device leads human blood out of the body, filters out specific molecular substances in the blood, and then returns the purified blood to the human body so as to achieve the effect of treating diseases.

The continuous blood purifying device is one of the common blood purifying devices. The blood purification device can remove excessive water in the body, remove metabolic wastes and toxic substances in the body, correct water electrolyte disturbance, ensure nutrition support, promote kidney function recovery, remove various cytokines and inflammatory mediators and the like.

The blood purification treatment is classified into various treatment modes such as slow continuous ultrafiltration, continuous venous-venous hemofiltration, continuous venous-venous hemodialysis, continuous venous-venous hemodiafiltration, double plasma molecular adsorption treatment, plasma adsorption, plasma exchange, double plasma exchange, blood perfusion, etc. Different modes of treatment for blood purification are applicable to different patients. In order to meet clinical use demands, although the blood purification apparatus may integrate a plurality of treatment modes of blood purification. But the number of the treatment modes which can be integrated at present is less, more treatment modes are difficult to be integrated, when the treatment modes of a plurality of patients in one intensive care unit are different, a plurality of blood purification devices are often needed to meet the treatment needs, the cost is greatly increased, the operation is relatively complicated, and the convenience is poor.

In addition, for patients who need to receive two different treatment modes, it is difficult for the operator to switch between the different treatment modes on the same blood purification apparatus, resulting in inconvenience of operation.

Disclosure of Invention

The present invention has been made to solve the above-mentioned technical problems. The embodiment of the invention provides a control method, a controller, purifying equipment and a system for blood purifying treatment modes, which solve the technical problems of less number of treatment modes integrated by blood purifying equipment, relatively complicated operation and poor convenience in the prior art.

As a first aspect of the present invention, the present invention provides a control method of a blood purification treatment mode, which is applied to a blood purification system including a plurality of pumps, at least one functional unit, and a plurality of connection lines connected between the pumps and the functional unit;

Wherein, the control method comprises the following steps:

Acquiring a target treatment mode input by a user, wherein the target treatment mode is one or more treatment modes in a plurality of preset treatment modes;

determining a target pipeline component matched with the target treatment mode according to the target treatment mode, wherein the target pipeline component comprises a target functional device, a target pump and a plurality of target connecting pipelines;

acquiring treatment data corresponding to the target treatment mode, and calculating a target opening of each target pump according to the treatment data and performance parameters of the target pump;

And controlling the target pump to start according to the target opening degree of each target pump so as to control the conduction of a plurality of target connecting pipelines and form a liquid loop corresponding to the target treatment mode.

In an embodiment of the present invention, the acquiring the target treatment mode input by the user includes:

Acquiring a target treatment type input by a user;

Determining a plurality of preset treatment modes corresponding to the target treatment type according to the target treatment type, so that the plurality of preset treatment modes are displayed on a display operation screen and are used for a user to select the target treatment mode;

and acquiring a target treatment mode selected by a user.

In one embodiment of the present invention, the blood purifying system includes a plurality of blood treatment components, wherein the plurality of blood treatment components are in one-to-one correspondence with a plurality of treatment types;

wherein determining a target circuit assembly that matches the target treatment pattern based on the target treatment pattern comprises:

determining a target treatment type corresponding to the target treatment mode from a plurality of treatment types according to the target treatment mode;

determining a target blood treatment component corresponding to the target treatment type in a plurality of blood treatment components according to the target treatment type;

and determining a target function device, a target pump and a target connecting pipeline corresponding to the target treatment mode in the target blood treatment component according to the treatment data of the target treatment mode.

In one embodiment of the present invention, the blood purification system further comprises at least one line selection valve having at least two valve ports, each of the valve ports being connected to one of the connecting lines;

The method for controlling the starting of the target pump according to the target opening of the target pump so as to control the conduction of a plurality of target connecting pipelines comprises the following steps:

Determining a target pipeline selection valve according to the target connecting pipeline;

and controlling the target pipeline selection valve to conduct the target connecting pipeline and controlling the target pipeline selection valve to cut off a reference connecting pipeline, wherein the reference connecting pipeline is a connecting pipeline except the target connecting pipeline in a plurality of connecting pipelines correspondingly connected with the target pipeline selection valve.

In one embodiment of the invention, the treatment types include hemodialysis, plasmapheresis, plasmaforporation and plasmafusion CRRT treatment, plasmafusion treatment and blood perfusion.

In one embodiment of the present invention, the preset treatment modes corresponding to the CRRT treatment include continuous pre-venous hemofiltration dilution (CVVH-pre), continuous post-venous hemofiltration dilution (CVVH-post), continuous pre-venous hemofiltration-post mixed dilution (CVVH-Mix), continuous pre-venous hemodiafiltration dilution (CVVHDF-pre), continuous post-venous hemodiafiltration dilution (CVVHDF-post), continuous pre-and post-venous hemodiafiltration mixed dilution (CVVHDF-Mix), continuous venous hemodialysis (CVVHD), and Slow Continuous Ultrafiltration (SCUF);

The preset treatment modes corresponding to the plasma treatment comprise Plasma Exchange (PE), double filtration plasma exchange (DFPP), paired plasma filtration adsorption (CPFA), plasma Adsorption (PA), double Plasma Molecular Adsorption System (DPMAS), molecular Adsorption and Recirculation System (MARS), plasma separation adsorption system (FPSA), single Pass Albumin Dialysis (SPAD), repeated Albumin Dialysis (RAD) and plasma filtration dialysis (PDF);

The preset treatment mode corresponding to the blood perfusion comprises blood perfusion (HP).

The invention also provides a controller of the blood purification treatment mode, which comprises a data acquisition module, a control module and a control module, wherein the data acquisition module is used for acquiring a target treatment mode input by a user, and the target treatment mode is one or more treatment modes in a plurality of preset treatment modes;

The first determining module is used for determining a target pipeline component matched with the target treatment mode according to the target treatment mode, and the target pipeline component comprises a target functional unit, a target pump and a plurality of target connecting pipelines;

The calculation module is used for acquiring treatment data corresponding to the target treatment mode and calculating the target opening of each target pump according to the treatment data and the performance parameters of the target pump;

and the regulation and control module is used for controlling the target pump to start according to the target opening of the target pump so as to control the conduction of the plurality of target connecting pipelines and form a liquid loop corresponding to the target treatment mode.

The invention also provides, as a third aspect of the invention, a blood purification apparatus comprising a plurality of pumps and the controller described above, the blood purification apparatus together with at least one functional unit, and a plurality of connecting lines connected between the pumps and the functional unit, constituting a blood purification system.

In one embodiment of the invention, the blood purification apparatus further comprises at least one line selection valve having at least two valve ports, each of the valve ports being connected to one of the connecting lines.

As a fourth aspect of the present invention, there is also provided a blood purification system comprising the above-described blood purification apparatus and at least one functional device, and a plurality of connecting lines connected between the pumps and the functional device;

When the treatment type is CRRT treatment, the corresponding functional device is a dialyzer and/or a filter;

when the treatment type is plasma treatment, the corresponding functional device is any one or a combination of a plurality of plasma separators, plasma component separators and plasma adsorbers;

and when the treatment type is blood perfusion, the corresponding functional device is a perfusion device.

The invention provides a control method of a blood purification treatment mode, and a blood purification device comprises a blood purification system which comprises five pumps, a plurality of functional devices and a plurality of connecting pipelines connected between the pumps and the functional devices. The target function, the target pump and the target pipeline are correspondingly determined according to the target treatment mode input by the user, the target opening of the target pump is calculated according to the treatment data of the target treatment mode, the starting of the target pump is controlled according to the target opening, and the conduction of the target pipeline is controlled so as to form a liquid loop corresponding to the target treatment mode, so that the patient can be treated according to the target treatment mode. The liquid loops corresponding to the multiple pipeline components can be combined by regulating the starting or disconnecting of the pump, the starting or disconnecting of the functional device and the on or off of the multiple connecting pipelines, and the liquid loops corresponding to the multiple pipeline components can correspond to multiple treatment modes, so that more treatment modes are integrated on one blood purification device, and the integration and the use convenience of the blood purification device are improved.

Drawings

The above and other objects, features and advantages of the present invention will become more apparent by describing embodiments of the present invention in more detail with reference to the attached drawings. The accompanying drawings are included to provide a further understanding of embodiments of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, and not constitute a limitation to the invention. In the drawings, like reference numerals generally refer to like parts or steps.

Fig. 1 is a circuit diagram of a blood treatment assembly corresponding to a CRRT treatment as a target treatment type according to an embodiment of the present invention.

Fig. 2 is a flow chart of a control method of a blood purification treatment mode according to an exemplary embodiment of the invention.

Fig. 3a is a circuit diagram of a liquid circuit corresponding to a target treatment mode of blood perfusion (HP) according to an exemplary embodiment of the present invention.

Fig. 3b is a circuit diagram of a liquid circuit corresponding to a Plasmapheresis (PE) target therapeutic mode according to an exemplary embodiment of the present invention.

Fig. 3c is a circuit diagram of a liquid circuit corresponding to a Plasma Adsorption (PA) as a target treatment mode according to an exemplary embodiment of the present invention.

Fig. 4 is a flowchart illustrating a control method of a blood purification treatment mode according to another exemplary embodiment of the present invention.

Fig. 5 is a flowchart illustrating a control method of a blood purification treatment mode according to another exemplary embodiment of the present invention.

Fig. 6 is a circuit diagram of a liquid circuit corresponding to continuous venous hemodialysis (CVVHD) as a target treatment mode according to an exemplary embodiment of the present invention.

Fig. 7 is a circuit diagram of a fluid circuit corresponding to a continuous pre-venous hemofiltration dilution (CVVH-pre) target treatment mode according to an exemplary embodiment of the present invention.

Fig. 8 is a circuit diagram of a fluid circuit corresponding to a continuous post-venous hemofiltration dilution (CVVH-post) target treatment mode according to an exemplary embodiment of the present invention.

Fig. 9 is a circuit diagram of a liquid circuit corresponding to a continuous intravenous hemofiltration pre-post Mix dilution CVVH-Mix) target treatment mode according to an exemplary embodiment of the present invention.

Fig. 10 is a circuit diagram of a fluid circuit corresponding to a continuous intravenous hemodiafiltration pre-dilution (CVVHDF-pre) target treatment mode according to an exemplary embodiment of the present invention.

Fig. 11 is a circuit diagram of a fluid circuit corresponding to a continuous intravenous hemodiafiltration post-dilution (CVVHDF-post) target therapy mode according to an exemplary embodiment of the present invention.

Fig. 12 is a circuit diagram of a liquid circuit corresponding to a continuous venous hemodiafiltration pre-post mixed dilution (CVVHDF-Mix) according to an exemplary embodiment of the present invention.

Fig. 13 is a circuit diagram of a fluid circuit corresponding to a Slow Continuous Ultrafiltration (SCUF) target therapy pattern according to an exemplary embodiment of the present invention.

Fig. 14 is a block diagram showing the operation of a controller for a blood purification treatment mode according to an exemplary embodiment of the present invention.

Fig. 15 is a block diagram illustrating an operation of an electronic device according to an exemplary embodiment of the present invention.

Reference numerals:

11-first flow pump, 12-second flow pump, 13-third flow pump, 14-fourth flow pump, 2-blood pump, 51-first line selection valve, 52-second line selection valve, 61-dialyzer, 62-plasma separator, 63-adsorber, 64-perfuser, 7-bubble monitor, 8-heater, 81-first replacement line, 82-second replacement line, 71-first adsorption line, 72-second adsorption line, 91-blood withdrawal line, 92-blood return line, 93-first CRRT line, 94-second CRRT line, 95-third CRRT line, 96-fourth CRRT line, 97-fifth CRRT line, 98-sixth CRRT line, 99-seventh CRRT line, 41-first pressure sensor, 42-second pressure sensor, 43-third pressure sensor, 44-fourth pressure sensor.

Detailed Description

Hereinafter, exemplary embodiments according to the present invention will be described in detail with reference to the accompanying drawings. It should be apparent that the described embodiments are only some embodiments of the present invention and not all embodiments of the present invention, and it should be understood that the present invention is not limited by the example embodiments described herein.

Exemplary blood purification apparatus

As a first aspect of the present invention, the present invention provides a blood purification apparatus including an apparatus main body and a display operation panel. The display operation screen is used for displaying contents to be displayed in the working process of the blood purification device, for example, displaying the integrated treatment type of the blood purification device and a plurality of preset treatment modes corresponding to each treatment type. The user can see the treatment types and a plurality of preset treatment modes corresponding to each treatment type on the display operation screen, and select a corresponding target treatment mode.

The blood purifying device provided by the invention further comprises a plurality of flow pumps, a blood pump and a pipeline selection valve.

The blood purification device, the at least one functional device and the plurality of connecting pipelines jointly form a blood purification system, and the plurality of connecting pipelines are used for communicating the flow pump, the blood pump and the functional device. Wherein the flow pump is used for pumping out or pumping in liquid at a preset pump speed. The blood pump is used for pumping out and conveying the blood of the patient body into the corresponding connecting pipeline. The pipeline selection valve is used for connecting a plurality of connecting pipelines, for example, the pipeline selection valve is a three-way valve, the three-way valve is provided with three pipeline selection valve ports, each pipeline selection valve port is respectively connected with one connecting pipeline, the connection and the disconnection of the connecting pipeline can be controlled by controlling the pipeline selection valve, and in addition, the flow rate of liquid flowing in the connecting pipeline can be controlled by controlling the opening degree of the pipeline selection valve. The functional device is a device for performing functional treatment on the liquid in each preset treatment mode, for example, the functional device may be a dialyzer 61, a plasma separator 62, an adsorber 63, a perfusion device 64, or the like.

Optionally, the blood purification system comprises a plurality of blood treatment components, wherein the plurality of blood treatment components are in one-to-one correspondence with a plurality of treatment types, for example, the blood treatment components corresponding to the treatment type CRRT treatment are blood dialysis components, and as shown in FIG. 1, the pipeline diagram of the blood treatment components corresponding to the treatment type CRRT treatment provided by one embodiment of the invention is shown in FIG. 1, the blood treatment components corresponding to the CRRT treatment comprise a dialyzer 61, a blood drawing pipeline 91, a blood return pipeline 92 and a blood pump 2 arranged on the blood drawing pipeline 91, the blood pump 2 is used for pumping blood in the blood drawing pipeline 91 into the dialyzer 61, and the blood return pipeline 92 is used for transporting blood dialyzed in the dialyzer 61 into a patient; a first CRRT pipeline 93 and a first flow pump 11 arranged on the first CRRT pipeline 93, wherein two ends of the first flow pump 11 are respectively communicated with the first CRRT pipeline 93 and a liquid storage bag, a second CRRT pipeline 94, a first pipeline selection valve 51 and a second flow pump 12, two ends of the second flow pump 12 are respectively communicated with the first CRRT pipeline 93 and the first pipeline selection valve 51, two ends of the second CRRT pipeline 94 are respectively communicated with the first pipeline selection valve 51 and a liquid outlet of the dialyzer 61, a third CRRT pipeline 95 and a third flow pump 13, one end of the third flow pump 13 is communicated with the first CRRT pipeline 93 and the second pipeline selection valve 52, the other end of the third flow pump 13 is communicated with one end of the third CRRT pipeline 95, the other end of the third CRRT pipeline 95 is communicated with a blood pumping pipeline 91 and a liquid inlet of the dialyzer 61, two ends of the sixth CRRT pipeline 98 are respectively communicated with the first pipeline selection valve 51 and the third CRRT pipeline 95, a seventh CRRT pipeline 99, the seventh CRRT line 99 has two ends respectively connected to the second line selector valve 52 and the third CRRT line 95, the fourth CRRT line 96 and the fourth flow pump 14, two ends of the fourth flow pump 14 respectively connected to the liquid inlet of the dialyzer 61 and the liquid storage bag, and two ends of the fifth CRRT line 97 respectively connected to the second line selector valve 52 and the liquid outlet of the dialyzer 61.

By controlling the opening or closing of the first flow pump 11, the second flow pump 12, the third flow pump 13, the fourth flow pump 14, the first line selector valve 51, and the second line selector valve 52, the blood drawing line 91, the blood return line 92, the first CRRT line 93, the second CRRT line 94, the third CRRT line 95, the fourth CRRT line 96, the fifth CRRT line 97, the sixth CRRT line 98, and the seventh CRRT line 99 can be turned on or off, so that 8 treatment modes of hemodialysis are applicable to the treatment type. The 8 treatment modes were continuous pre-venous hemofiltration dilution (CVVH-pre), continuous post-venous hemofiltration dilution (CVVH-post), continuous pre-venous hemofiltration-post-mixed dilution (CVVH-Mix), continuous pre-venous hemodiafiltration dilution (CVVHDF-pre), continuous post-venous hemodiafiltration dilution (CVVHDF-post), continuous pre-venous hemodiafiltration-post-mixed dilution (CVVHDF-Mix), continuous venous hemodialysis (CVVHD), and Slow Continuous Ultrafiltration (SCUF), respectively.

Optionally, the blood purification device further comprises a heater 8 and a bubble monitor 7, the heater 8 being used for heating the substitution or dialysis fluid, the bubble monitor 7 being used for monitoring whether bubbles are present in the blood return line 92.

Optionally, the blood purification device further comprises a pressure sensor arranged on the connection line, e.g. a first pressure sensor 41 arranged in front of the blood pump 2 and the blood line 91, a second pressure sensor 42 arranged between the blood pump 2 and the blood line 91, a third pressure sensor 43 arranged on the blood circuit 92, a fourth pressure sensor 44 arranged on the fourth CRRT line.

Exemplary control method

As a second aspect of the present invention, the present invention provides a method of controlling a blood purification treatment mode, which is applicable to the blood purification system described above. Fig. 2 shows a method for controlling a blood purification treatment mode according to an embodiment of the present invention, where the method for controlling a blood purification treatment mode includes the following steps:

s1, acquiring a target treatment mode input by a user.

Specifically, a plurality of preset treatment modes integrated in the blood purification device are stored in a preset database in advance, and the treatment type, a plurality of preset treatment modes included in the treatment type and liquid connection pipelines corresponding to each preset treatment mode are stored in the preset database.

Specifically, the specific manner of acquiring the target treatment pattern input by the user, that is, S1 (acquiring the target treatment pattern input by the user) may include the following steps:

s11, acquiring a target treatment type input by a user;

when the user starts the blood purification device, the treatment type is displayed on the display operation screen in the blood purification device, the user selects the target treatment type, and the controller acquires the target treatment type input by the user.

In particular, treatment types include CRRT treatment, plasma treatment, and blood perfusion.

(1) The treatment patterns corresponding to CRRT treatment include the following 8 treatment patterns:

Serial pre-hydrostatic hemofiltration dilution (CVVH-pre), serial post-hydrostatic hemofiltration dilution (CVVH-post), serial pre-hydrostatic hemofiltration-post mixed dilution (CVVH-Mix), serial pre-hydrostatic hemodiafiltration dilution (CVVHDF-pre), serial post-hydrostatic hemodiafiltration dilution (CVVHDF-post), serial pre-hydrostatic hemodiafiltration-post mixed dilution (CVVHDF-Mix), serial hydrostatic hemodialysis (CVVHD), slow Continuous Ultrafiltration (SCUF).

(2) The treatment modes corresponding to plasma treatment include the following 10 treatment modes:

Plasma Exchange (PE), double filtration plasma exchange (DFPP), paired plasma filtration adsorption (CPFA), plasma Adsorption (PA), double Plasma Molecular Adsorption System (DPMAS), molecular Adsorption and Recirculation System (MARS), plasma separation and adsorption system (FPSA), single Pass Albumin Dialysis (SPAD), repeated Albumin Dialysis (RAD), and plasma filtration dialysis (PDF).

(3) The treatment modes corresponding to plasma perfusion include the following 1 treatment modes:

Plasma perfusion (HP).

S12, determining a plurality of preset treatment modes corresponding to the target treatment type according to the target treatment type so that the plurality of preset treatment modes are displayed on a display operation screen;

when the controller acquires the target treatment type input by the user, a preset treatment mode matched with the target treatment type is searched in a preset database according to the target treatment type, for example, when the target treatment type selected by the user is CRRT treatment, the corresponding preset treatment mode is the 8 treatment modes.

After determining a plurality of preset treatment modes corresponding to the target treatment type, the controller sends the corresponding plurality of preset treatment modes to the display operation screen, the display operation screen displays the corresponding plurality of preset treatment modes, for example, 8 treatment modes corresponding to CRRT treatment are displayed, chinese names of the treatment modes can be displayed when the treatment modes are displayed, english abbreviations corresponding to the treatment modes can be limited, for example, the 8 treatment modes displayed by the display operation screen are CVVH-front, CVVH-rear, CVVH-Mix, CVVHDF-front, CVVHD and CVVHDF-Mix, CUF, SPAD, RAD.

S13, acquiring a target treatment mode selected by a user.

When a plurality of preset treatment modes corresponding to the target treatment types are displayed on the display operation screen, the user can correspondingly select the target treatment modes, and after the user clicks the target treatment modes on the display operation screen, the controller can acquire the target treatment modes input by the user. For example, when the user clicks and selects CVVHDF-Mix on the display operation screen, the corresponding controller acquires the target treatment mode input by the user, namely continuous intravenous hemodiafiltration pre-post mixed dilution (CVVHDF-Mix).

S2, determining a target pipeline assembly matched with the target treatment mode according to the target treatment mode, wherein the target pipeline assembly comprises a plurality of target pumps, a target functional device and a plurality of target connecting pipelines;

Specifically, the target pipeline components corresponding to each treatment mode are stored in the preset database, namely, the target pipeline components comprise a target pump, a target functional device and a target connecting pipeline which are required by the target treatment mode, so that after the target treatment mode input by a user is determined, the corresponding target pipeline components can be matched in the preset database according to the target treatment mode.

For example, as shown in fig. 3a, when the target treatment mode input by the user is a plasma perfusion mode, the corresponding target function device is a perfusion device 64, and the target pump is a blood pump 2. The target connecting pipeline is a blood drawing pipeline 91 and a blood return pipeline 92.

Also for example, as shown in FIG. 3b, when the user enters a target treatment mode of Plasmapheresis (PE), the corresponding target functionality for Plasmapheresis (PE) is a plasma separator 62. The target pumps are the blood pump 2, the fourth flow pump 14 and the first flow pump 11. The target connecting lines are a blood drawing line 91, a blood return line 92, a first replacement line 81 and a second replacement line 82, the second replacement line 82 is used for pumping the blood plasma in the liquid storage bag into the blood return line 92, and the first replacement line 81 and the fourth flow pump 14 are used for conveying the waste liquid generated by the blood plasma separator 62 into the waste liquid bag.

As also shown in fig. 3c, when the target treatment mode inputted by the user is Plasma Adsorption (PA), the target function corresponding to the Plasma Adsorption (PA) is a plasma separator 62 and an adsorber 63. The target pump is the blood pump 2 and the first flow pump 11. The target connection lines are a blood drawing line 91, a blood circuit 92, a first adsorption line 71, and a second adsorption line 72. Wherein the first adsorption line 71 is connected between the outlet of the plasma separator 62 and one end of the adsorber 63, and the second adsorption line 72 is connected between the blood circulation line 92 and the other end of the adsorber 63.

Also for example, as shown in FIG. 8, when the user enters the target treatment mode is serial intravenous post-hemofiltration dilution (CVVH-post). The treatment data of continuous intravenous blood filtration post-dilution (CVVH-post) is that the treatment time is more than 24 hours, the blood pump flow is 50-200ml/min, the kidney dosage is 20-25 ml/(kg) h), the ultrafiltration flow is the kidney dosage, the patient weight is the patient weight, the replacement fluid flow is 1500-2000ml/h, and no dialyzate exists. The target function device in the target line assembly corresponding to the target treatment mode is the dialyzer 61, the target pumps are the blood pump 2, the fourth flow pump 14 and the first flow pump 11, the target connecting lines are the blood drawing line 91, the blood return line 92, the first CRRT line 93 connected between the liquid storage bag and the first flow pump 11, the second CRRT line 94 connected between the first CRRT line 93 and the blood return line 92, and the fourth CRRT line 96 connected between the liquid inlet of the dialyzer 61 and the waste liquid bag.

After the target pipeline assembly is determined, the pipeline diagram corresponding to the target pipeline assembly can be displayed on the display operation screen, namely, the pipeline diagram shown in fig. 3 is displayed on the display operation screen so as to guide a user to assemble the target pipeline assembly according to the pipeline diagram, namely, the user can connect the target pipeline between the target pump and the target functional device according to the pipeline diagram corresponding to the target pipeline assembly displayed on the display operation screen so as to form a liquid loop of the corresponding target pipeline assembly.

S3, acquiring treatment data corresponding to a target treatment mode, and calculating a target opening of the target pump according to the treatment data and performance parameters of the target pump;

After the user finishes linking the pipelines according to the target pipeline assembly, the controller can acquire the treatment data corresponding to the target treatment mode. Specifically, the treatment data of the target treatment mode may be input by a user, or the corresponding treatment data may be searched in a preset database.

After the treatment data corresponding to the target treatment mode is determined, the target opening of the target pump can be calculated according to the treatment data and the performance parameters of the target pump.

Specifically, the performance parameter of the target pump is the corresponding relation between the opening degree and the pump speed.

And S4, controlling the target pump to start according to the target opening of the target pump, and controlling the conduction of a plurality of target connecting pipelines so as to form a liquid loop corresponding to the target treatment mode with the target liquid bag.

After the target opening of each target pump is determined, the target pumps can be controlled to be started according to the opening of each target pump, and the plurality of target connecting pipes are controlled to be conducted so as to form a liquid loop corresponding to a target treatment mode with the target liquid bag, so that blood pumped out of the patient is infused back into the patient after treatment.

In one embodiment of the present invention, the blood purification system includes a plurality of blood treatment assemblies that are in one-to-one correspondence with a plurality of treatment types, such as the treatment type of the blood treatment assemblies shown in fig. 1 is CRRT treatment. Then, as shown in fig. 4, S2 (determining the target line assembly matching the target treatment pattern based on the target treatment pattern) may include the steps of:

s21, determining a target treatment type corresponding to the target treatment mode in a plurality of treatment types according to the target treatment mode;

the treatment type corresponding to each treatment mode can be stored in the preset database, so that after the user inputs the target treatment mode, the controller can match in the preset database according to the target treatment mode so as to determine the target treatment type corresponding to the target treatment mode.

For example, if the user enters a target treatment pattern of continuous intravenous blood post-filtration dilution (CVVH-post), then the corresponding target treatment type is CRRT treatment.

S22, determining a target blood treatment component corresponding to the target treatment type in a plurality of blood treatment components according to the target treatment type;

When the target treatment type of the target treatment pattern is determined, the target treatment type may be determined to select a corresponding target blood treatment assembly from the plurality of blood treatment assemblies. For example, when the treatment type of the target treatment pattern is CRRT treatment, a target blood treatment component corresponding to CRRT treatment, that is, a blood treatment component as shown in fig. 1, may be determined.

After the target blood treatment component is determined, the target blood treatment component is displayed on the display operation screen, and the user can manually connect the corresponding pump, the functional device and the connecting pipeline according to the pipeline diagram of the target blood treatment component displayed on the display operation screen so as to form the pipeline corresponding to the target blood treatment component.

And S23, determining a target function device, a target pump and a target connecting pipeline corresponding to the target treatment mode in the target blood treatment component according to the treatment data of the target treatment mode.

The corresponding target function and target pump are selected in the target blood treatment assembly, so that the corresponding target pump can be selected more quickly.

Specifically, the specific determination manner of the target function and the target pump in the target blood treatment assembly according to the target treatment mode may be:

and determining a target functional device according to the treatment data corresponding to the target treatment mode, and then determining a target pump according to the target functional device.

For example, the target treatment mode input by the user is Slow Continuous Ultrafiltration (SCUF), the corresponding target blood treatment component is a blood treatment component corresponding to CRRT treatment (as shown in fig. 1), the treatment data of the Slow Continuous Ultrafiltration (SCUF) is that the treatment time is at least 24 hours, the blood pump flow is 50-100ml/min, the renal measurement is 20-25 ml/(kg×h), the ultrafiltration flow is 2-5ml/min, the total ultrafiltration amount is not more than 4L, no substitution liquid and no dialysis liquid. The treatment data of the Slow Continuous Ultrafiltration (SCUF) do not need replacement liquid or dialysis liquid, and only needs dialysis, so that the target therapeutic device can be determined to be a dialyzer in the target blood treatment assembly shown in fig. 1, the target pump can be a pump capable of pumping out waste liquid after dialysis, and the fourth flow pump can be determined to be a target pump.

And S24, determining a target connecting pipeline in the target blood treatment assembly according to the target functional device and the target pump.

After the target pump and target function are selected, the target connection line may be determined based on the target pump and target function.

For example, when the user-entered target treatment mode is Slow Continuous Ultrafiltration (SCUF), the dialyzer is directly determined to be the target function and the fourth flow pump 14 is the target pump in the blood treatment assembly shown in fig. 1. The fourth CRRT line 96 is defined directly in the target blood treatment assembly as the target connection line.

When the patient changes the target treatment mode and the treatment type of the changed target treatment mode is still the same treatment mode, the pump, the connecting pipeline and the functional device do not need to be assembled again manually. The corresponding pump, the functional device and the connecting pipeline can be selected directly according to the replaced target treatment mode, and the corresponding pump and the functional device are directly controlled to be started and the corresponding connecting pipeline is controlled to be conducted. At the same time, the pump is controlled to be closed and the connecting pipeline is controlled to be cut off independently of the target treatment mode after replacement.

In an embodiment of the present invention, the blood purification system further includes a line selection valve, in addition to the pump, the functional device and the connection line, the line selection valve has at least two valve ports, each valve port is connected to one connection line, that is, two or more connection lines can be communicated through the line selection valve, and the two connection lines can be communicated or disconnected by controlling the opening or closing of the line selection valve. For example, a blood purification system includes a blood treatment set (as shown in fig. 1) that includes 2 line selection valves, a first line selection valve 51 and a second line selection valve 52, respectively. The three ports of the first line selector valve 51 are respectively in communication with the first CRRT line 93, the second CRRT line 94, and the sixth CRRT line 98. The three ports of the second line selector valve 52 are respectively in communication with the third CRRT line 95, the seventh CRRT line 99, and the fifth CRRT line 97. The first CRRT line 93 and the second CRRT line 94, the second CRRT line 94 and the sixth CRRT line 98, and the first CRRT line 93 and the sixth CRRT line 98 are turned on or off by controlling the opening or closing of the three valve ports of the first line selector valve 51. The third and seventh CRRT lines 95 and 99, the seventh and fifth CRRT lines 99 and 97, and the third and fifth CRRT lines 95 and 97 are turned on or off by controlling the opening or closing of the three ports of the second line selector valve 52.

By arranging the pipeline selection valve, the whole blood purification system can adopt fewer pumps to form more liquid loops so as to adapt to more treatment modes.

When the blood purification system includes the line selection valve, when the control target line is turned on, it is necessary to control the line selection valve to turn on the target line, that is, as shown in fig. 5, S4 (control the start of the target pump according to the target opening degree of each target pump to control the conduction of the plurality of target connection lines) specifically includes the steps of:

S41, determining a target pipeline selection valve according to the target connecting pipeline;

When the target connection pipe is determined, if the target connection pipe is connected with the pipe selection valve, the target pipe selection valve corresponding to the target connection pipe is determined, for example, when the target treatment mode input by the user is continuous venous hemodialysis (CVVHD), the blood drawing pipe 91, the blood return pipe 92, the fourth CRRT pipe 96, and the second CRRT pipe 94 are determined to be the target connection pipe in the blood treatment module (as shown in fig. 1) corresponding to the treatment type of the CRRT treatment corresponding to the continuous venous hemodialysis (CVVHD), and then the first pipe selection valve 51 on the second CRRT pipe 94 is determined to be the target pipe selection valve. .

S42, controlling a target pipeline selection valve to lead a target connecting pipeline and controlling the target pipeline selection valve to cut off a reference connecting pipeline, wherein the reference connecting pipeline is a connecting pipeline except the target connecting pipeline in a plurality of connecting pipelines correspondingly connected with the target pipeline selection valve;

When the target pipeline selection valve is determined, the target pipeline selection valve can be controlled to lead the target connecting pipeline and cut off other connecting pipelines except the target connecting pipeline.

For example, the user inputted target treatment mode is continuous venous hemodialysis (CVVHD), the target pump is determined to be the dialyzer 61, the target connection lines are a blood drawing line 91, a blood return line 92, a fourth CRRT line 96, a second CRRT line 94, and a first CRRT line 93, and the target line selection valve is a first line selection valve 51.

The first pipeline selector valve 51 can be controlled to stop the second CRRT pipeline 94 and the sixth CRRT pipeline 97 and to connect the second CRRT pipeline 94 and the first CRRT pipeline 93, and at the same time, the second pipeline selector valve 52 is not started to operate. .

And S43, controlling a plurality of target pumps to start according to the target opening degree of each target pump.

The target treatment mode input by the user is continuous venous hemodialysis (CVVHD), and since the blood pump 2, the fourth flow pump 14, and the first flow pump 11 are determined as target pumps, the control of the blood pump 2, the fourth flow pump 14, and the first flow pump 11 is conducted, and a line diagram of the target line components of continuous venous hemodialysis (CVVHD) is shown in fig. 6.

The present invention will be described in detail below by taking specific examples as an example for better understanding of the present invention. The treatment type of the treatment pattern corresponding to examples 1-9 was CRRT treatment, and the blood treatment component corresponding to CRRT treatment was CRRT treatment component, as shown in fig. 1.

Example 1A target treatment modality was continuous intravenous blood dilution before filtration (CVVH-front)

Serial intravenous blood dilution before filtration (CVVH-before) is to dilute blood with substitution liquid before hemodialysis, and the corresponding treatment data is that the treatment time is more than 24 hours, the blood pump flow is 50-200ml/min, the kidney dosage is 20-25 ml/(kg) h), and the substitution liquid flow is 1500-2000ml/l.

The control method of the blood purification treatment mode comprises the following steps:

s101, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S102, determining the dialyzer 61 as a target function device, the blood pump 2, the third flow pump 13, the fourth flow pump 14 and the first flow pump 11 as target pumps and the third CRRT pipeline 95, the first CRRT pipeline 93, the fourth CRRT pipeline 96, the blood pumping pipeline 91 and the blood return pipeline 92 as target connecting pipelines according to treatment data of continuous intravenous blood dilution before CVVH-front;

S103, determining the opening of the blood pump 2, the opening of the third flow pump 13, the opening of the fourth flow pump 14 and the opening of the first flow pump 11 according to the treatment data of continuous intravenous blood dilution before filtration (CVVH-before);

The opening degree of the blood pump 2 is calculated according to the blood pump flow rate (50-200 ml/min) in the treatment data and the performance parameter of the blood pump 2.

The opening degrees of the first flow pump 11 and the third flow pump 13 are calculated from the flow rate (1500-2000 ml/l) of the substitution liquid in the treatment data.

The opening of the fourth flow pump 14 is an opening at which the waste liquid in the dialyzer 61 is pumped out.

S104, controlling the blood pump to start to conduct the blood drawing pipeline, controlling the first flow pump 11 to conduct the first CRRT pipeline, controlling the fourth flow pump 14 to be opened so that the fourth CRRT pipeline is communicated with the liquid outlet of the dialyzer 61, and controlling the third flow pump 13 so that the third CRRT pipeline 95 is communicated with the first CRRT pipeline 93.

And S105, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the second flow pump 12, the first line selector valve 51, and the second line selector valve 52 are controlled to stop, and the first CRRT line 93 and the second CRRT line 94 are blocked, and the first CRRT line 93 and the seventh CRRT line 99 are blocked. After S101-S105, the liquid circuit of continuous intravenous hemofiltration pre-dilution (CVVH-pre) is shown in FIG. 7.

Example 2 treatment of interest was performed in the continuous intravenous blood filtration post dilution (CVVH-post)

Continuous intravenous blood filtration post dilution (CVVH-post) is to dilute blood with substitution liquid after hemodialysis, and the corresponding treatment data is that the treatment time is more than 24 hours, the blood pump flow is 50-200ml/min, the kidney dosage is 20-25 ml/(kg) h), and the substitution liquid flow is 1500-2000ml/l.

S201, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S202, determining the dialyzer 61 as a target function device, the blood pump 2, the fourth flow pump 14, the second flow pump 12 and the first flow pump 11 as target pumps and the second CRRT pipeline 94, the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the blood return pipeline 92 as target connecting pipelines according to treatment data of continuous intravenous blood post-filtration dilution (CVVH-post);

S203, determining the opening of the blood pump 2, the opening of the fourth flow pump 14 and the opening of the first flow pump 11 according to the treatment data of continuous intravenous blood post-filtration dilution (CVVH-).

The opening degree of the first flow pump 11 and the second flow pump 12 is calculated from the flow rate of the substitution liquid (1500-2000 ml/l), the performance parameter of the first flow pump 11 and the performance parameter of the second flow pump 12 in the treatment data.

S204, controlling the blood pump 2 to start to conduct the blood drawing pipeline 91, controlling the first flow pump 11 to start to conduct the first CRRT pipeline 93 and the replacement fluid storage bag, controlling the first flow pump 12 to start to conduct communication between the first CRRT pipeline 93 and the second CRRT pipeline 94 and to stop the first CRRT pipeline 93 and the sixth CRRT pipeline 98, controlling the fourth flow pump 14 to start so that the fourth CRRT pipeline 96 is communicated with the liquid outlet of the dialyzer 61, and S105, controlling the rest devices except the target pump in the CRRT treatment assembly to stop working so as to stop the rest connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the third flow pump 13 and the second pipeline selector valve 52 are controlled to stop working, the first CRRT pipeline 93 and the third CRRT pipeline 95 are cut off, the first CRRT pipeline 93 and the fifth CRRT pipeline 97 are cut off, the first CRRT pipeline 93 and the seventh CRRT pipeline 99 are cut off, and the fifth CRRT pipeline 97 and the seventh CRRT pipeline 99 are cut off. .

After S201-S205, the liquid circuit of continuous intravenous blood post-filtration dilution (CVVH-post) is shown in FIG. 8.

Example 3 treatment of interest mode was continuous intravenous blood filtration pre-post Mix dilution (CVVH-Mix)

The continuous intravenous blood filtration pre-post mixing dilution (CVVH-Mix) adopts substitution liquid to dilute blood before and after hemodialysis, the corresponding treatment data are that the treatment time is more than 24 hours, the blood pump flow is 50-200ml/min, the kidney dosage is 20-25 ml/(kg) h), the pre-substitution liquid flow is 1500-2000ml/l, and the post-substitution liquid flow is 1500-2000ml/l.

S301, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S302, determining the dialyzer 61 as a target function according to treatment data of continuous intravenous blood filtration pre-post mixing dilution (CVVH-Mix), determining the blood pump 2, the fourth flow pump 14, the second flow pump 12 and the first flow pump 11 as target pumps, determining the second CRRT pipeline 94, the first CRRT pipeline 93, the second CRRT pipeline 94, the third CRRT pipeline 95, the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the blood return pipeline 92 as target connecting pipelines, and determining the first pipeline selection valve 51 and the second pipeline selection valve 52 as target pipeline selection valves;

S303, determining the opening degree of the blood pump 2, the opening degree of the first flow pump 11, the opening degree of the second flow pump 12 and the opening degree of the fourth flow pump 14 according to the treatment data of continuous intravenous blood filtration pre-post mixing dilution (CVVH-Mix);

The opening of the first flow pump 11 is calculated based on the sum of the pre-displacement fluid flow rate (1500-2000 ml/l) and the post-displacement fluid flow rate (1500-2000 ml/l) in the treatment data, and the performance parameter of the first flow pump, and the opening of the second flow pump 12 is calculated based on the post-displacement fluid flow rate (1500-2000 ml/l) and the performance parameter of the second flow pump 12.

S304, controlling the blood pump 2 to start to conduct the blood drawing pipeline 91, controlling the first flow pump 11 to start to conduct the replacement liquid storage bag and the first CRRT pipeline 93, controlling the second flow pump 12 to start and 2 ports of the first pipeline selection valve 51 to open to conduct the first CRRT pipeline 93 and the second CRRT pipeline 94 and stopping the first CRRT pipeline 93 and the sixth CRRT pipeline 98;

the fourth flow pump 14 is controlled to be started so that the fourth CRRT line 96 communicates with the drain port of the dialyzer 61, and 2 ports of the second line selector valve 52 are controlled to be opened to conduct the first CRRT line 93 and the seventh CRRT line 99 and to close the seventh CRRT line 99 and the fifth CRRT line 97.

And S305, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the third flow pump 13 is controlled to stop to shut off the first CRRT line 93 and the third CRRT line 95..

After S301-S305, the liquid circuit of continuous intravenous hemofiltration pre-post mixed dilution (CVVH-Mix) is shown in FIG. 9.

Example 4A target treatment modality was continuous resting hemodiafiltration pre-dilution (CVVHDF-pre)

The continuous intravenous hemodialysis pre-filtration dilution (CVVHDF-pre) has the corresponding treatment data of treatment time of more than 24 hours, blood pump flow rate of 50-200ml/min, kidney dosage of 20-25 ml/(kg) h), substitution fluid flow rate of 1000-1500ml/l and dialysate flow rate of 1000-1500ml/l.

S401, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S402, determining the dialyzer 61 as a target function device, determining the blood pump 2, the fourth flow pump 14, the third flow pump 13 and the first flow pump 11 as target pumps, determining the first CRRT pipeline 93, the fifth CRRT pipeline 97, the third CRRT pipeline 95, the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the return pipeline 92 as target connecting pipelines and determining the second pipeline selection valve 52 as a target pipeline selection valve according to treatment data of continuous intravenous hemodiafiltration pre-dilution (CVVHDF-pre);

S403, determining the opening of the blood pump 2, the opening of the first flow pump 11, the opening of the third flow pump 13 and the opening of the fourth flow pump 14 according to the treatment data of dilution before continuous intravenous hemodiafiltration (CVVHDF-);

The opening of the first flow pump 11 is calculated from the substitution fluid flow rate (1000-1500 ml/l) and the performance parameters of the first flow pump in the treatment data, and the opening of the third flow pump 13 is calculated from the dialysate flow rate (1000-1500 ml/l) and the performance parameters of the third flow pump 13.

S404, controlling the blood pump 2 to start so as to conduct the blood drawing pipeline 91, controlling the first flow pump 11 and the third flow pump 13 to start and controlling 2 valve ports of the second pipeline selector valve 52 to open so as to conduct the first CRRT pipeline 93 and the third CRRT pipeline 95, conduct the first CRRT pipeline 93 and the fifth CRRT pipeline 97 and cut off the first CRRT pipeline 93 and the seventh CRRT pipeline 99;

the fourth flow pump 14 is controlled to be activated so that the fourth CRRT line 96 communicates with the drain port of the dialyzer 61.

And S405, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the second flow pump 12 is controlled to stop, the first line selector valve 51 is controlled to stop (i.e., all three ports are closed) to shut off the first CRRT line 93 and the second CRRT line 94, and to shut off the first CRRT line 93 and the sixth CRRT line 98.

After S401-S405, the liquid circuit of the continuous venous hemodiafiltration pre-dilution (CVVHDF-pre) is shown in FIG. 10.

Example 5A target treatment modality was continuous resting hemodiafiltration post dilution (CVVHDF-post)

The continuous intravenous hemodialysis post-dilution (CVVHDF-post) has the corresponding treatment data of treatment time of more than 24 hours, blood pump flow rate of 50-200ml/min, kidney dosage of 20-25 ml/(kg) h), substitution fluid flow rate of 1000-1500ml/l and dialysate flow rate of 1000-1500ml/l.

S501, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

s502, determining the dialyzer 61 as a target function device, determining the blood pump 2, the fourth flow pump 14, the second flow pump 12 and the first flow pump 11 as target pumps, determining the first CRRT pipeline 93, the fifth CRRT pipeline 97, the second CRRT pipeline 94, the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the blood return pipeline 92 as target connecting pipelines and determining the first pipeline selection valve 51 and the second pipeline selection valve 52 as target pipeline selection valves according to treatment data of continuous intravenous hemodialysis post-dilution (CVVHDF-;

s503, determining the opening degree of the blood pump 2, the opening degree of the first flow pump 11, the opening degree of the second flow pump 12 and the opening degree of the fourth flow pump 14 according to the treatment data of continuous intravenous hemodialysis post-dilution (CVVHDF-);

The opening of the first flow pump 11 is calculated according to the sum of the replacement fluid flow (1000-1500 ml/l) and the dialysate flow (1000-1500 ml/l) in the treatment data and the performance parameters of the first flow pump, and the opening of the second flow pump 12 is calculated according to the replacement fluid flow (1000-1500 ml/l) and the performance parameters of the second flow pump 12.

S504, controlling the blood pump 2 to start to conduct the blood drawing pipeline 91, controlling the first flow pump 11 and the second flow pump 12 to start and controlling 2 ports of the first pipeline selector valve 51 to open to conduct the first CRRT pipeline 93 and the second CRRT pipeline 94 and to stop the first CRRT pipeline 93 and the sixth CRRT pipeline 98. 2 ports of the second line selector valve 52 are controlled to open to conduct the first CRRT line 93 and the fifth CRRT line 97 and to close the first CRRT line 93 and the seventh CRRT line 99.

And S505, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the third flow pump 13 is controlled to be turned off, i.e., the third flow pump 13 is not activated, to shut off the first CRRT line 93 and the third CRRT line 95..

After S501-S505, the liquid circuit of continuous venous hemodiafiltration post-dilution (CVVHDF-post) is shown in FIG. 11.

Example 6 the target treatment modality is continuous resting hemodialysis (CVVHD)

The continuous intravenous hemodialysis (CVVHD) has the corresponding treatment data of treatment time of more than 24 hours, blood pump flow rate of 50-200ml/min, kidney dosage of 20-25 ml/(kg) h) and dialysate flow rate of 1000-1500ml/l.

S601, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S602, determining the dialyzer 61 as a target functional device, determining the blood pump 2, the fourth flow pump 14 and the first flow pump 11 as target pumps, determining the first CRRT pipeline 93, the fifth CRRT pipeline 97, the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the blood return pipeline 92 as target connecting pipelines and determining the second pipeline selection valve 52 as target pipeline selection valves according to treatment data of continuous intravenous hemodialysis (CVVHD);

S603, determining the opening degree of the blood pump 2, the opening degree of the first flow pump 11 and the opening degree of the fourth flow pump 14 according to the treatment data of continuous venous hemodialysis (CVVHD);

The opening of the first flow pump 11 is calculated from the dialysate flow (1000-1500 ml/l) in the treatment data, the performance parameters of the first flow pump 11 and the second flow pump 12.

S604, controlling the blood pump 2 to start to conduct the blood drawing pipeline 91, controlling the first flow pump 11 to start to conduct the dialysate storage bag and the first CRRT pipeline 93, controlling the two valve ports of the second pipeline selection valve 52 to open to conduct the first CRRT pipeline 93 and the fifth CRRT pipeline 97, and stopping the first CRRT pipeline 93 and the seventh CRRT pipeline 99.

Controlling the fourth flow pump 14 to start so that the fourth CRRT line 96 communicates with the drain port of the dialyzer 61;

And S605, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the second flow pump 12 and the third flow pump 13 are controlled to stop working to stop the first CRRT line 93 and the second CRRT line 94, to stop the first CRRT line 93 and the fifth CRRT line 95, and to control the three ports of the first line selector valve 51 to be closed to stop the first CRRT line 93 and the sixth CRRT line 98, and to stop the sixth CRRT line 98 and the second CRRT line 94..

After S601-S605, the liquid circuit of continuous venous hemodialysis (CVVHD) is shown in FIG. 6.

Example 7 treatment of the target mode was continuous intravenous hemodiafiltration pre-post Mix dilution (CVVHDF-Mix)

The continuous intravenous hemodialysis pre-post-filtration mixed dilution (CVVHDF-Mix) is characterized by that after hemodialysis, the blood is diluted by using substitution liquor, and its correspondent therapeutic data includes therapeutic time is above 24 hr, blood pump flow rate is 50-200ml/min, renal dose is 20-25 ml/(kg) h), substitution liquor flow rate is 1000-1500ml/l and dialysate flow rate is 1000-1500ml/l.

S701, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S702, determining the dialyzer 61 as a target function, determining the blood pump 2, the third flow pump 13, the fourth flow pump 14, the second flow pump 12 and the first flow pump 11 as target pumps, determining the first CRRT line 93, the third CRRT line 95, the fifth CRRT line 97, the second CRRT line 94, the fourth CRRT line 96, the blood drawing line 91 and the blood return line 92 as target connection lines, and determining the first line selector valve 51 and the second line selector valve 52 as target line selector valves according to the treatment data of the continuous venous hemodiafiltration pre-post mixing dilution (CVVHDF-Mix);

S703, determining the opening degree of the blood pump 2, the opening degree of the first flow pump 11, the second flow pump 12, the third flow pump 13 and the fourth flow pump 14 according to the treatment data of continuous intravenous hemodiafiltration pre-post mixing dilution (CVVHDF-Mix);

The opening of the first flow pump 11 is calculated from the sum of the substitution fluid flow (1000-1500 ml/l) and the dialysate flow (1000-1500 ml/l) in the treatment data and the performance parameter of the first flow pump 11, the opening of the second flow pump 12 is calculated from the substitution fluid flow (1000-1500 ml/l) and the performance parameter of the second flow pump 12, and the opening of the third flow pump 13 is calculated from the dialysate flow (1000-1500 ml/l) and the performance parameter of the third flow pump 13.

S704, controlling the blood pump 2 to start so as to conduct the blood drawing pipeline 91, controlling the first flow pump 11 and the third flow pump 13 to start and controlling 2 ports of the second pipeline selection valve 52 to open so as to conduct the first CRRT pipeline 93 and the third CRRT pipeline 95, conducting the first CRRT pipeline 93 and the fifth CRRT pipeline 97 and stopping the fifth CRRT pipeline 97 and the seventh CRRT pipeline 99, controlling the second flow pump 12 to start and controlling 2 ports of the first pipeline selection valve 51 so as to conduct the first CRRT pipeline 93 and the fourth CRRT pipeline 94 and stopping the first CRRT pipeline 93 and the sixth CRRT pipeline 98;

And S705, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. .

After S701-S705, the liquid circuit of continuous venous hemodiafiltration pre-post mixed dilution (CVVHDF-Mix) is shown in FIG. 12.

Example 8 target treatment modality Slow Continuous Ultrafiltration (SCUF)

The Slow Continuous Ultrafiltration (SCUF) has corresponding treatment data of treatment time of at least 24 hours, blood pump flow rate of 50-100ml/min, kidney metering of 20-25 ml/(kg h), ultrafiltration flow rate of 2-5ml/min, total ultrafiltration amount of no more than 4L, no substitution liquid, and no dialysate.

S801, determining a treatment type of a target treatment mode as CRRT treatment, determining a corresponding target treatment type as CRRT treatment in a plurality of treatment types according to the CRRT treatment, and determining a corresponding target blood treatment component as a CRRT treatment component in a plurality of blood treatment components according to the CRRT treatment;

S802, determining the dialyzer 61 as a target functional device, the blood pump 2 and the fourth flow pump 14 as target pumps and the fourth CRRT pipeline 96, the blood drawing pipeline 91 and the blood return pipeline 92 as target connecting pipelines according to treatment data of Slow Continuous Ultrafiltration (SCUF);

s803 determining the opening of the blood pump 2 and the opening of the fourth flow pump 14 from the treatment data of the Slow Continuous Ultrafiltration (SCUF);

S804, the blood pump 2 is controlled to be started to conduct the blood drawing line 91, and the fourth flow pump 14 is controlled to be started so that the fourth CRRT line 96 is communicated with the drain port of the dialyzer 61.

And S805, controlling all other devices except the target pump in the CRRT treatment assembly to stop working so as to cut off the other connecting pipelines except the target connecting pipeline in the CRRT treatment assembly. For example, the first flow pump 11, the second flow pump 12, and the third flow pump 13 are controlled to stop, and the three ports of the first line selector valve 51 and the second line selector valve 52 are controlled to be closed.

After S801 to S805, the liquid loop of the Slow Continuous Ultrafiltration (SCUF) is shown in fig. 13.

Exemplary controller

As a third aspect of the present invention, the present invention also provides a controller for a blood purification treatment mode, as shown in fig. 14, the controller 100 comprising:

The data acquisition module 101 is configured to acquire a target treatment mode input by a user, where the target treatment mode is one or more treatment modes of multiple preset treatment modes;

A first determining module 102, configured to determine a target pipeline assembly matched with the target treatment mode according to the target treatment mode, where the target pipeline assembly includes a target functional unit, a target pump, and a plurality of target connection pipelines;

A calculating module 103, configured to obtain treatment data corresponding to the target treatment mode, and calculate a target opening of each target pump according to the treatment data and performance parameters of the plurality of target pumps;

The regulating and controlling module 104 is used for controlling the starting of the target pump according to the target opening of the target pump so as to control the conduction of the plurality of target connecting pipelines and form a liquid loop corresponding to the target treatment mode.

Exemplary blood-purifying System

As a fourth aspect of the present invention, the present invention also provides a blood purification system comprising the above-described blood purification apparatus, at least one functional unit, a reservoir bag storing a target liquid, and a plurality of connecting lines connected between the pump and the functional unit.

By the control method of the treatment mode, the corresponding functional device, the target liquid storage bag storing the target liquid and the target device (such as the target pump, the target pipeline selection valve and the like) in the blood purifying equipment are selected according to the target treatment mode, and the corresponding target connecting pipeline is selected according to the target device so as to form the liquid pipeline corresponding to the target treatment mode.

In particular, the blood purification system may include a plurality of blood treatment components in one-to-one correspondence with a plurality of treatment types, e.g., when the treatment type is CRRT treatment, the corresponding blood treatment component is a CRRT treatment component, as shown in fig. 1.

when the treatment type is blood perfusion, the corresponding functional device is a perfusion device.

Exemplary electronic device

Fig. 15 illustrates a block diagram of an electronic device according to an embodiment of the invention.

As shown in fig. 15, the electronic device 200 includes one or more processors 201 and memory 202.

The processor 201 may be a Central Processing Unit (CPU) or other form of processing unit having data processing and/or instruction execution capabilities, and may control other components in the electronic device 200 to perform desired functions.

Memory 202 may include one or more computer program products that may include various forms of computer-readable storage media, such as volatile memory and/or non-volatile memory. The volatile memory may include, for example, random Access Memory (RAM) and/or cache memory (cache), and the like. The non-volatile memory may include, for example, read Only Memory (ROM), hard disk, flash memory, and the like. One or more computer program instructions may be stored on the computer readable storage medium that can be executed by the processor 201 to implement the method of controlling a blood purification treatment mode and/or other desired functions of the various embodiments of the present invention described above. Various contents such as an input signal, a signal component, a noise component, and the like may also be stored in the computer-readable storage medium.

In one example, electronic device 200 may also include input device 203 and output device 204, which are interconnected by a bus system and/or other forms of connection mechanisms (not shown).

When the electronic device 200 is a stand-alone device, the input means 203 may be a communication network connector for receiving the acquired input signals from the first device and the second device.

In addition, the input device 203 may also include, for example, a keyboard, a mouse, and the like.

The output device 204 may output various information to the outside, including the determined distance information, direction information, and the like. The output device 204 may include, for example, a display, speakers, a printer, and a communication network and remote output apparatus connected thereto, etc.

Of course, only some of the components of the electronic device 200 relevant to the present invention are shown in fig. 15 for simplicity, components such as buses, input/output interfaces, and the like being omitted. In addition, the electronic device 200 may include any other suitable components depending on the particular application.

The computer program product may write program code for performing operations of embodiments of the present invention in any combination of one or more programming languages, including an object oriented programming language such as Java, C++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computing device, partly on the user's device, as a stand-alone software package, partly on the user's computing device, partly on a remote computing device, or entirely on the remote computing device or server.

The computer readable storage medium may employ any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium may include, for example, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or a combination of any of the foregoing. More specific examples (a non-exhaustive list) of a readable storage medium include an electrical connection having one or more wires, a portable disk, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

The foregoing description has been presented for purposes of illustration and description. Furthermore, this description is not intended to limit embodiments of the invention to the form disclosed herein. Although a number of example aspects and embodiments have been discussed above, a person of ordinary skill in the art will recognize certain variations, modifications, alterations, additions, and subcombinations thereof.

Claims

1. A control method for a blood purification treatment mode, characterized in that it is applicable to a blood purification system, wherein the blood purification system comprises: a plurality of pumps, at least one functional device, and a plurality of connecting pipes connected between the pumps and between the pumps and the functional device;

Wherein, the control method comprises:

Acquire a target treatment mode input by a user, where the target treatment mode is one or more treatment modes among a plurality of preset treatment modes;

Determine a target pipeline component matching the target treatment mode according to the target treatment mode, the target pipeline component comprising: a target function device, a target pump and a plurality of target connecting pipelines;

Acquiring treatment data corresponding to the target treatment mode, and calculating a target opening degree of each target pump according to the treatment data and performance parameters of the target pump;

The target pump is started up according to the target opening of the target pump to control the conduction of the plurality of target connecting pipelines to form a liquid circuit corresponding to the target treatment mode.

2. The control method according to claim 1, characterized in that the step of obtaining the target treatment mode input by the user comprises:

Get the target treatment type input by the user;

Determining a plurality of preset treatment modes corresponding to the target treatment type according to the target treatment type, so that the plurality of preset treatment modes are displayed on a display operation screen for a user to select a target treatment mode;

Gets the target treatment mode selected by the user.

3. The control method according to claim 1 or 2, characterized in that the blood purification system comprises a plurality of blood treatment components, and the plurality of blood treatment components correspond one-to-one to a plurality of treatment types;

Wherein, determining a target pipeline component matching the target treatment mode according to the target treatment mode includes:

According to the target treatment mode, determining a target treatment type corresponding to the target treatment mode from among the multiple treatment types;

According to the target treatment type, determining a target blood treatment component corresponding to the target treatment type among the plurality of blood treatment components;

According to the treatment data of the target treatment mode, a target functional device, a target pump and a target connecting pipeline corresponding to the target treatment mode are determined in the target blood treatment component.

4. The control method according to claim 3, characterized in that the blood purification system further comprises: at least one pipeline selection valve, the pipeline selection valve having at least two valve ports, each of the valve ports being connected to one of the connecting pipelines;

Wherein, the starting of the target pump is controlled according to the target opening of the target pump to control the conduction of the plurality of target connecting pipelines, including:

The target pipeline selection valve is controlled to conduct the target connecting pipeline, and the target pipeline selection valve is controlled to cut off a reference connecting pipeline, wherein the reference connecting pipeline is a connecting pipeline other than the target connecting pipeline among a plurality of connecting pipelines correspondingly connected to the target pipeline selection valve.

5. The control method according to any one of claims 1-4, characterized in that the treatment types include: CRRT treatment, plasma therapy and hemoperfusion.

6. The control method according to claim 5, characterized in that:

The preset treatment modes corresponding to the CRRT treatment include: continuous venovenous hemofiltration pre-dilution (CVVH-pre), continuous venovenous hemofiltration post-dilution (CVVH-post), continuous venovenous hemofiltration pre-post mixed dilution (CVVH-Mix), continuous venovenous hemodiafiltration pre-dilution (CVVHDF-pre), continuous venovenous hemodiafiltration post-dilution (CVVHDF-post), continuous venovenous hemodiafiltration pre-post mixed dilution (CVVHDF-Mix), continuous venovenous hemodialysis (CVVHD), slow continuous ultrafiltration (SCUF);

The preset treatment modes corresponding to the plasma therapy include: plasma exchange (PE), double filtration plasma exchange (DFPP), paired plasma filtration adsorption (CPFA), plasma adsorption (PA), dual plasma molecular adsorption system (DPMAS), molecular adsorption recirculation system (MARS), plasma separation adsorption system (FPSA), single pass albumin dialysis (SPAD), repeated albumin dialysis (RAD), plasma filtration dialysis (PDF);

The preset treatment modes corresponding to the blood perfusion include: blood perfusion (HP).

7. A controller for a blood purification treatment mode, characterized by comprising:

A data acquisition module, used to acquire a target treatment mode input by a user, wherein the target treatment mode is one or more treatment modes among a plurality of preset treatment modes;

A first determination module is used to determine a target pipeline component matching the target treatment mode according to the target treatment mode, wherein the target pipeline component includes: a target function device, a target pump, and a plurality of target connecting pipelines;

a calculation module, used for acquiring treatment data corresponding to the target treatment mode, and calculating a target opening degree of each target pump according to the treatment data and the performance parameters of the target pump;

The control module is used to control the start-up of the target pump according to the target opening of the target pump, so as to control the conduction of the plurality of target connecting pipelines to form a liquid circuit corresponding to the target treatment mode.

8. A blood purification device, comprising:

A plurality of pumps and a controller as claimed in claim 7;

The blood purification device, at least one functional device, and a plurality of connecting pipelines connected between the pumps and between the pumps and the functional devices together constitute a blood purification system.

9. The blood purification device according to claim 8 is characterized in that the blood purification device further comprises: at least one pipeline selection valve, the pipeline selection valve has at least two valve ports, and each of the valve ports is connected to one of the connecting pipelines.

10. A blood purification system, characterized in that the blood purification system comprises: the blood purification device according to claim 8 or 9 and at least one functional device, and a plurality of connecting pipelines connected between the pumps and between the pumps and the functional devices;

When the treatment type is plasma therapy, the corresponding functional device is any one or more combinations of a plasma separator, a plasma component separator, and a plasma adsorber;