CN119454067A

CN119454067A - SPECT imaging device, SPECT imaging system, and diagnostic combination

Info

Publication number: CN119454067A
Application number: CN202411510672.7A
Authority: CN
Inventors: 陈牧; 吴承峰
Original assignee: Foshan Ruidio Medical System Co ltd
Current assignee: Foshan Ruidio Medical System Co ltd
Priority date: 2023-08-09
Filing date: 2023-08-09
Publication date: 2025-02-18
Also published as: WO2025030623A1; CN116849690A; CN116849690B

Abstract

The invention discloses a SPECT imaging device, a SPECT imaging system and a diagnostic combination. The SPECT imaging device includes a gantry and a nuclear detector set. The frame is provided with a through hole for the detected object to pass through. The through hole has a central axis. The nuclear detector group is arranged on the end face of the frame, and comprises a plurality of longitudinal detectors arranged on the upper side and the lower side of the central axis and a plurality of transverse detectors arranged on the left side and the right side of the central axis, wherein the longitudinal detectors are used for acquiring longitudinal images of detected objects, the transverse detectors are used for acquiring transverse images of the detected objects, and the distance between the longitudinal detectors and the central axis is smaller than the distance between the transverse detectors and the central axis. The SPECT imaging device provided by the invention has the advantages of improving the acquisition efficiency, increasing the sensitivity and improving the resolution of the detection image.

Description

SPECT imaging device, SPECT imaging system, and diagnostic combination

The application is a divisional application based on the application application with the application number 202310995766.7, the application date 2023, 8 and 9, the application name of Buddha Ruidiao medical System Co., ltd, and the application creation name of 'SPECT imaging device, SPECT imaging system and diagnosis combination'.

Technical Field

The present invention relates to a SPECT imaging device, a SPECT imaging system, and a diagnostic combination.

Background

A SPECT imaging system (SPECT, single-Photon Emission Computed Tomography) is a Single photon emission computed tomography (ct) imaging device that detects the absorption distribution of a radiopharmaceutical in a patient, and displays the metabolic activity of an organ or tissue under examination to realize clinical image judgment of nuclear medicine.

In the related art, SPECT imaging systems include two symmetrically disposed or adjacently disposed detectors. In examining a patient, it is necessary to rotate around the patient's body one revolution to obtain complete sample data for image reconstruction. This results in long scanning time and reduced inspection efficiency.

It should be noted that the statements in this background section merely provide background information related to the present disclosure and may not necessarily constitute prior art.

Disclosure of Invention

The present invention provides a SPECT imaging device, a SPECT imaging system, and a diagnostic combination to improve the resolution and detection sensitivity of a detection image.

A first aspect of the present invention provides a SPECT imaging device comprising:

a frame having a through hole for passing the object to be detected therethrough, the through hole having a central axis, and

The nuclear detector group is arranged on the end face of the frame and comprises a plurality of longitudinal detectors arranged on the upper side and the lower side of the central axis and a plurality of transverse detectors arranged on the left side and the right side of the central axis, the longitudinal detectors are used for acquiring longitudinal images of detected objects, the transverse detectors are used for acquiring transverse images of the detected objects, and the distance between the longitudinal detectors and the central axis is smaller than the distance between the transverse detectors and the central axis.

In some embodiments, the longitudinal detector covers a scan range that is larger than the scan range covered by the transverse detector in the circumferential direction of the nuclear detector array distribution.

In some embodiments, the number of longitudinal detectors is 2-10, preferably 2, 4, 6, and/or the number of transverse detectors is 2-8, preferably 2, 4.

In some embodiments, the gantry is configured to not rotate, or the gantry is configured to rotate less than 90 ° about the central axis to complete a truncated scan detection of the detected object.

In some embodiments, the longitudinal detector is configured to be movably disposed in a radial direction to be proximate to the object under test, and/or the lateral detector is configured to be movably disposed in a radial direction to be proximate to the object under test.

In some embodiments, the plurality of longitudinal probes includes a first longitudinal probe having a working surface disposed parallel or oblique to a transverse axis and a second longitudinal probe having a working surface parallel to the transverse axis, the transverse axis extending perpendicular to the central axis and in a transverse direction.

In some embodiments, the angle between the working face of the first longitudinal detector and the working face of the second longitudinal detector is 0 ° to 60 °, preferably 0 ° to 30 °.

In some embodiments, the plurality of lateral detectors includes a first lateral detector having a working surface disposed parallel or oblique to the longitudinal axis and a second lateral detector having a working surface disposed oblique to the longitudinal axis, the longitudinal axis extending perpendicular to the central axis and in the longitudinal direction.

In some embodiments, the angle between the working face of the first transverse detector and the working face of the second transverse detector is 0 ° to 60 °, preferably 0 ° to 30 °.

In some embodiments, the plurality of longitudinal probes includes a first longitudinal probe having a working surface that is disposed obliquely with respect to the lateral axis and a second longitudinal probe having a working surface that is disposed obliquely with respect to the lateral axis, and the plurality of lateral probes includes a first lateral probe having a working surface that is disposed obliquely with respect to the longitudinal axis and a second lateral probe having a working surface that is disposed obliquely with respect to the longitudinal axis, wherein the longitudinal axis, the lateral axis, and the central axis are perpendicular to one another.

In some embodiments, the angle of the working face of the longitudinal detector is adjustably set, or the angle of the working face of the lateral detector is adjustably set.

In some embodiments, the detectors of the nuclear detector set comprise large-area sodium iodide continuous crystals or regular-volume cesium iodide crystals, or the detectors of the nuclear detector set comprise sodium iodide crystals and coupled photo-devices, wherein the photo-devices are arranged on the back surface of the sodium iodide crystals in a fitting way, and the photo-devices comprise photomultiplier tube (PMT) arrays or silicon photomultipliers, or the detectors of the nuclear detector set comprise cesium iodide crystals and coupled photo-devices, the photo-devices are arranged on the back surface of the sodium iodide crystals in a fitting way, and the photo-devices comprise photomultiplier tube (PMT) arrays or silicon photomultipliers.

In some embodiments, the ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3): 1-2): preferably (1.5-2.5): 1, or the longitudinal detector comprises a longitudinal probe array which is arranged in a (4-16) ×4-16 manner, preferably (8-12) ×8-12 manner, or the transverse detector comprises a transverse probe array which is arranged in a (6-10) ×6-10 manner.

In some embodiments, the distance between the detector of the nuclear detector group and the detected object is 2-250 mm, preferably 2-10 mm or 10-180 mm, or the distance between the projection point of the rotation center on the transverse detector and the central line of the transverse detector is 10-25mm,25-40mm respectively, and the distance is not changed along with the angle change.

In some embodiments, the gantry is configured to rotate in steps between-30 ° and 30 ° about the central axis, preferably the distance between the detectors of the nuclear detector group and the object to be detected is constantly set to 15mm.

A second aspect of the present invention provides a SPECT imaging system including the SPECT imaging device described above and a control system including:

the self-checking module is used for adapting to different protocols before diagnosis and determining collimator type, energy window combination, retrieval type, injection time and injection dosage;

the detection module is used for controlling the starting angle and the ending angle of the stand and selecting a fixed position mode or a mode closest to the human body distance, is further configured to control the stand to rotate to a set angle, control the detector to move to a set distance, control the detector to rotate to the set angle and scan according to a preset scanning mode after scanning starts, and is further configured to determine whether scanning is ended according to a time count or a total event count or a gating count.

In some embodiments, the control system further comprises a compensation module for checking a scanning effect, the scanning effect comprising a scanning completion degree and a resolution, the compensation module further being for determining whether to perform a compensation scan according to the checking result and determining a compensation scan angle and a compensation scan distance according to the checking result, and the compensation module being configured to control the detection module to perform the compensation scan, or the control system further comprising a reset module for moving the detector to a maximum outer diameter and controlling the gantry to rotate to a 0 ° position.

A third aspect of the invention provides a diagnostic combination comprising a SPECT imaging system as described above and a SPECT diagnostic drug.

In some embodiments, the SPECT diagnostic agent is administered at a dose of 0.1-1mCi/kg, preferably 0.1-0.5mCi/kg, more preferably 0.1mCi/kg, 0.2mCi/kg, 0.3mCi/kg, 0.4mCi/kg, 0.5mCi/kg, or the diagnostic combination is tested for a single case for a period of 5-60 minutes, preferably 5-50 minutes, 5-40 minutes, 5-45 minutes, 10-45 minutes, 15-30 minutes, 15-20 minutes, more preferably 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes.

Based on the technical scheme provided by the invention, the SPECT imaging device comprises a frame and a nuclear detector group. The frame is provided with a through hole for the detected object to pass through. The through hole has a central axis. The nuclear detector group is arranged on the end face of the frame, and comprises a plurality of longitudinal detectors arranged on the upper side and the lower side of the central axis and a plurality of transverse detectors arranged on the left side and the right side of the central axis, wherein the longitudinal detectors are used for acquiring longitudinal images of detected objects, the transverse detectors are used for acquiring transverse images of the detected objects, and the distance between the longitudinal detectors and the central axis is smaller than the distance between the transverse detectors and the central axis. According to the SPECT imaging device, the distance between the upper longitudinal detector and the lower longitudinal detector is set to be smaller and the included angle is set, the distance between the left transverse detector and the right transverse detector is set to be larger and the included angle is set, the circumferential distribution of the detectors is approximately elliptical and is consistent with the cross section shape of a patient body, the distance between the longitudinal detectors positioned on the upper side and the lower side of the patient and the patient body is further enabled to be closer, the upper longitudinal detector, the lower longitudinal detector, the left transverse detector and the right transverse detector form a trapezoid, photons in different directions can be collected more, the upper longitudinal detector, the lower longitudinal detector, the left transverse detector, the right transverse detector, the left transverse detector, the right transverse detector and the left transverse detector are adopted as an aid to supplement resolution, and transverse sampling angle data are obtained, and further resolution and detection sensitivity of detection images are improved.

The asymmetric detector design and flexible adjustment of the angle and the distance of the detector are better in fitting degree with the contour of a patient, can realize that single-bed scanning does not need to be completely rotated for 360 degrees or even rotate, can realize the aim of fully sampling the distribution of the radioactive medicaments, realize the dynamic rapid slice imaging function, can shorten the detection time of whole-body scanning to be within 15 minutes, greatly shortens the clinical detection time and improves the overall operation efficiency of equipment. The problems that the detector cannot be fully utilized and the detection efficiency is low due to frequent radial movement and rotation of the detector in the detection process and gaps exist between different detectors are avoided, the utilization efficiency of the detector is effectively improved, the problems that the thickness of a sodium iodide or cesium iodide crystal detector is thicker, and full rotation of each angle cannot be realized in actual production are effectively solved, the cost is saved, and the detection sensitivity and resolution are improved.

Based on the structure and the generated beneficial effects, the SPECT imaging system provided by the invention obviously reduces the detection time and the nuclear medicine application amount of a single case in clinical application, reduces the systemic toxic and side effects on patients, reduces the detection cost and improves the application accessibility of detection equipment.

Other features of the present invention and its advantages will become apparent from the following detailed description of exemplary embodiments of the invention, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute a limitation on the application. In the drawings:

fig. 1 is a schematic perspective view of a SPECT device according to some embodiments of the present invention.

Fig. 2 is a simplified schematic structural diagram of a SPECT device of some embodiments of the present invention.

Fig. 3 is a schematic view of a gantry of a SPECT device of some embodiments of the present invention in a detection initial position.

Fig. 4 is a schematic view of a gantry of a SPECT device of some embodiments of the present invention in a detection end position.

Fig. 5 is a front view of a SPECT device of some embodiments of the present invention.

Fig. 6 is a detector deflection schematic of a SPECT device in accordance with an embodiment of the present invention.

Fig. 7 is a process diagram of a SPECT device of some embodiments of the present invention from a detection initial position to a detection end position.

Fig. 8 is a diagram of a detection process of a SPECT device according to some embodiments of the present invention.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods, and apparatus should be considered part of the specification. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

Spatially relative terms, such as "above," "upper" and "upper surface," "above" and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the process is carried out, the exemplary term "above" may be included. Upper and lower. Two orientations below. The device may also be positioned in other different ways and the spatially relative descriptions used herein are construed accordingly.

As mentioned above, the detectors of existing SPECT imaging systems are all symmetrically disposed or adjacently disposed, such that the detectors need to be at least 180 ° or 360 ° around the patient's body in order to meet the integrity of the data sampling.

However, the inventors of the present application have found during the course of the study that the cross-sectional shape of the contour of the human body when the patient is in the examination position, i.e., when the patient is in a lying position, is approximately an ellipse. That is to say the width of the body contour of the patient is greater than the thickness thereof. Wherein, the thickness refers to the distance from the chest side to the back side of the human body, and the width refers to the distance from the left shoulder side to the right shoulder side of the human body. If the symmetrically arranged detectors are adopted, the distance between the detector and the patient body can be relatively long when the detector detects at one side of the thickness direction of the patient body, and then the acquired detection image is unclear, and part of the detectors in the width direction of the human body can be wasted.

In response to this problem, referring to fig. 1 and 2, a SPECT imaging device provided by an embodiment of the present application includes a gantry 12 and a nuclear detector set 20. The frame 12 has a through hole through which the object to be inspected passes. The through hole has a central axis. The nuclear detector group 20 is disposed on an end surface of the frame 12, and the nuclear detector group 20 includes a plurality of longitudinal detectors disposed on upper and lower sides of the central axis and a plurality of transverse detectors disposed on left and right sides of the central axis, the plurality of longitudinal detectors being configured to acquire longitudinal images of the detected object, the plurality of transverse detectors being configured to acquire transverse images of the detected object, a distance between the longitudinal detectors and the central axis being smaller than a distance between the transverse detectors and the central axis. According to the SPECT imaging device, the distance between the upper longitudinal detector and the lower longitudinal detector is set to be smaller and the included angle is set, the distance between the left transverse detector and the right transverse detector is set to be larger and the included angle is set, the asymmetric arrangement enables the plurality of detectors to form an irregular quadrangle, the circumferential distribution of the detectors in rotation in detection approximately forms an ellipse, the ellipse is consistent with the section shape of a patient body, the distance between the longitudinal detectors positioned on the upper side and the lower side of the patient and the patient body is further enabled to be closer, the upper longitudinal detector and the lower longitudinal detector are enabled to be close to the human body as much as possible to obtain optimal sensitivity, longitudinal non-cutoff data are obtained, the left transverse small detector and the right transverse small detector are used as assistance to supplement resolution, and the resolution and the detection sensitivity of a detection image are further improved.

Referring to fig. 1, in some embodiments, the frame 12 is a cylindrical structure. And the housing 12 has a through hole penetrating in the axial direction. The bed board is arranged in the through hole in a penetrating way and is used for enabling the detection object to lie flat. The end face of the axial forward end of the gantry 12 is mounted with a nuclear detector array 20.

Specifically, the frame 12 includes a frame stator 11 and a frame rotor that rotates about a central axis relative to the frame stator 11 under the drive of the driver. The nuclear detector assembly 20 is disposed on the gantry rotor for rotation under the drive of the gantry rotor. The nuclear detector array 20 is used to acquire the distribution of absorption of the radiopharmaceutical in the patient.

In some embodiments, the number of the longitudinal detectors is 2-10, preferably 2, 4 and 6. The number of the transverse detectors is 2-8, preferably 2 and 4. If the number of the longitudinal detectors is more than 4, and the number of the transverse detectors is also more than 4, a plurality of detectors are respectively arranged up and down or left and right, so that the plurality of detectors of the nuclear detector group are distributed into irregular multi-deformation and can be more and more attached to a complete ellipse, and better attached to the human body contour.

And in one embodiment shown in fig. 1 and 2, the nuclear detector group 20 is composed of two longitudinal detectors disposed on the upper and lower sides of the central axis, respectively, and two transverse detectors disposed on the left and right sides of the central axis, respectively. Two longitudinal detectors are used to acquire longitudinal images of the object under test. Two transverse detectors are used to acquire transverse images of the object under inspection. The distance between the longitudinal probe and the central axis is smaller than the distance between the transverse probe and the central axis.

In some embodiments, the detector comprises sodium iodide crystals or cesium iodide crystals. For example, the detector is a flat panel detector of different size arrays of sodium iodide crystals or cesium iodide crystals plus coupled optoelectronic devices.

Specifically, the detectors of the nuclear detector group 20 include large-area sodium iodide (NaI) continuous crystals or regular-volume cesium iodide (Csl) crystals.

The detectors of the nuclear detector array 20 include sodium iodide crystals and coupled photo-electric devices attached to the back of the sodium iodide crystals, the photo-electric devices including photomultiplier tube (PMT) arrays or silicon photomultipliers.

The detectors of the nuclear detector array 20 include cesium iodide crystals and coupled photo-electric devices. The photoelectric device is attached to the back of the sodium iodide crystal. The photo-devices include photomultiplier tube (PMT) arrays or silicon photomultipliers.

The ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3): 1-2, preferably (1.5-2.5): 1. That is, the width of the longitudinal probe is greater than the width of the transverse probe, where the width refers to the dimension of the probe in the direction of extension of the central axis.

In some embodiments, the longitudinal probe comprises a longitudinal probe array, and the longitudinal probe array is arranged in a (4-16) x (4-16) manner, preferably (8-12) x (8-12).

In some embodiments, the transverse probe comprises a transverse probe array, and the transverse probe array is arranged in a (6-10) x (6-10) manner.

The nuclear detector group 20 includes a first longitudinal detector 21, a second longitudinal detector 22, a first transverse detector 23, and a second transverse detector 24 disposed in the circumferential direction. Wherein the first longitudinal detector 21 is arranged above the detected object, the second longitudinal detector 22 is arranged below the detected object, the first transverse detector 23 is arranged on the left side of the detected object, and the second transverse detector 24 is arranged on the right side of the detected object.

The distance between each detector and the detected object is 2-250 mm, preferably 2-10 mm or 10-180 mm.

In other embodiments, the projected point of the center of rotation on the left lateral detector is 10-25mm,25-40mm, respectively, from the center line of the right lateral detector, as opposed to varying with angle.

To expand the detection range of the nuclear detector array 20 and thereby reduce the angle at which the gantry 12 rotates during detection, in some embodiments, the longitudinal detectors cover a greater scan range than the transverse detectors in the circumferential direction of the nuclear detector array 20 distribution. Referring to fig. 2, the coverage of the longitudinal probe is greater than that of the lateral probe in terms of the cross-sectional shape. Therefore, the four detectors are arranged to basically realize full coverage of the detected object in the circumferential direction, so that the frame 12 can obtain full-direction detection of the detected object without rotating or rotating a small angle when the detected object is detected, complete images are obtained, and the detection efficiency is improved.

In some embodiments, the frame 12 is configured to not rotate. Because the four detectors are adopted to cover the whole body basically, the missing acquisition at the trapezoid included angle formed by the four detectors can be made up by an algorithm, and static or dynamic scanning can be completed without rotating a frame.

In other embodiments, the gantry 12 is configured to rotate less than 90 ° about a central axis to accomplish a truncated scan test of the test object. In the embodiment of the application, four detectors are arranged in the circumferential direction of the detected object, the scanning ranges of the two longitudinal detectors are set to be larger, and the scanning ranges of the two transverse detectors are set to be smaller, so that the four detectors can basically realize full coverage of the detected object in the circumferential direction. The lack of angle can be detected by only controlling the housing 12 to rotate a small angle.

Referring to fig. 3,4 and 7, in some embodiments, the housing 12 has a detection initial position and a detection end position. Wherein fig. 3 shows the detection of the initial position. Fig. 4 shows the detection end position. The frame 12 is configured to rotate counterclockwise to reach the detection initial position. Fig. 7 shows a schematic view of the position of the gantry 12 at five angles-30 °, -15 °,0 °, +15°, and +30° with respect to the center of rotation.

As shown in fig. 7, the home position of the housing 12 is at-30 °. The detection end position of the gantry 12 is at +30°. The gantry 12 is configured to rotate stepwise around the central axis between-30 deg. and 30 deg., preferably the distance between the detectors of the nuclear detector group 20 and the object to be detected is constantly set to 15mm.

To improve the adaptability of SPECT imaging systems of embodiments of the present invention, in some embodiments, the longitudinal detector is configured to be movably disposed in a radial direction to be close to the detected object. The radial direction refers to the radial direction of the through hole. For different detected objects, such as different fat and thin detected objects, a clearer detected image can be obtained by moving the longitudinal detector in the radial direction to be close to the detected object as much as possible.

Further, in other embodiments, the lateral detector is configured to be movably disposed in a radial direction to be close to the object to be detected. For example, for children and adults, the lateral width of the child is narrower than for adults, a clearer detection image can be obtained by moving the lateral detector in the radial direction to be as close as possible to the object to be detected.

In some embodiments, the lead screw or synchronous belt is driven by a servo motor to drive the detector to move along the radial direction so as to push or pull the detector to be close to the human body contour, thereby improving the resolution and the sensitivity of key parameters.

In some embodiments, the two longitudinal detectors include a first longitudinal detector 21 and a second longitudinal detector 22. The detection surface of the first longitudinal detector 21 is arranged obliquely with respect to a transverse axis x, parallel to which the detection surface of the second longitudinal detector 22 extends perpendicularly to the central axis and in a transverse direction.

According to the embodiment of the invention, the detection surface of the first longitudinal detector 21 is obliquely arranged relative to the transverse axis, and the detection surface of the second longitudinal detector 22 is parallel to the transverse direction, namely, the first longitudinal detector 21 and the second longitudinal detector 22 are asymmetrically arranged, so that the detection range of the first longitudinal detector 21 is enlarged, the rack 12 can realize the purpose of fully sampling the distribution of the radiopharmaceuticals without rotating 360 degrees or even without rotating, and the sampling efficiency is improved.

The detection surface of the detector means a surface of the detector that is close to the object to be detected and that receives radiation. For example, in the embodiment shown in fig. 5, the detector is a square structure. The detection surface refers to a side surface of the square structure on the side close to the object to be detected. For the state shown in fig. 5, the detection surface of the first longitudinal detector 21 is the bottom surface thereof. For the second longitudinal detector 22, its detection surface is the top surface. The detection surface of the first transverse detector 23 is the right side surface. The detection surface of the second transverse detector 24 is the left side surface.

In some embodiments, the angle α between the detection surface of the first longitudinal detector 21 and the detection surface of the second longitudinal detector 22 is 0 ° to 60 °. Preferably, α is 0 ° to 30 °.

In other embodiments not shown in the figures, the detection surface of the second longitudinal detector 22 is at an angle to the transverse axis x. The angle gamma between the detection surface of the first longitudinal detector 21 and the second longitudinal detector 22 is now greater than alpha.

In some embodiments, the two lateral detectors include a first lateral detector 23 and a second lateral detector 24. The detection surface of the first transversal detector 23 is arranged obliquely with respect to the longitudinal axis y and the detection surface of the second transversal detector 24 is arranged obliquely with respect to the longitudinal axis y, which is perpendicular to the central axis and extends in the longitudinal direction.

As shown in fig. 5, the angle β between the detection surface of the first transversal detector 23 and the longitudinal axis y is larger than the angle b between the detection surface of the second transversal detector 24 and the longitudinal axis y. The angle θ=β+b between the detection surface of the first lateral detector 23 and the detection surface of the second lateral detector 24.

In some embodiments, the angle β between the detection face of the first lateral detector 23 and the second lateral detector 24 is 0 ° to 60 °. Beta is 0-30 degrees.

Preferably, the angle α between the detection surface of the first longitudinal detector 21 and the transverse axis x is 2 to 10 °. The angle beta between the detection surface of the first transverse detector 23 and the longitudinal axis y is 6-14 deg.. The angle b between the detection surface of the second transversal detector 24 and the longitudinal axis y is 1-6 °.

In a specific embodiment, as shown in fig. 5 to 6, the two longitudinal probes comprise a first longitudinal probe 21 and a second longitudinal probe 22. The detection surface of the first longitudinal detector 21 is arranged obliquely with respect to the transverse axis and the detection surface of the second longitudinal detector 22 is parallel to the transverse axis. The two transversal detectors comprise a first transversal detector 23 and a second transversal detector 24, the detection surface of the first transversal detector 23 being arranged obliquely with respect to the longitudinal axis and the detection surface of the second transversal detector 24 being arranged obliquely with respect to the longitudinal axis, wherein the transversal axis x, the longitudinal axis y and the central axis are perpendicular to each other. The angle α between the detection surface of the first longitudinal detector 21 and the transverse axis x is 6 °. The angle beta between the detection face of the first transversal detector 23 and the longitudinal axis y is 8 deg.. The angle b between the detection surface of the second transversal detector 24 and the longitudinal axis y is 2 deg.. Under the above preferred angle, the minimum gap between each detector and the human body contour can be realized, and the parameter resolution and sensitivity are improved. At the above preferred angles, the detector is allowed to cover as many angles as possible through rotation of the gantry 12, rather than only obtaining redundant data.

In some embodiments, the angle of the working face of the longitudinal detector is adjustably set. The angle of the working face of the longitudinal detector is adjusted to obtain photon detection images of more angles, particularly non-repeated angles, so that a more comprehensive inspection result is obtained. By adjusting the angle of the working surface of the longitudinal detector, the gap coverage left at the included angle of the adjacent detectors can be realized, and the clinical scanning of the human body cut-off of the bed can be maximally realized without changing any rotation angle.

Specifically, a servo motor or a stepping motor drives a lead screw or a synchronous belt and a mechanical mechanism such as a gear is used for enabling the detector to swing around the center line at a small angle left and right, so that gamma photons irradiated from different angles are regulated and received, and data acquisition is maximized.

In particular, the longitudinal probe is configured to be rotatably disposed about its own axis to adjust the angle of its working face.

In other embodiments, the angle of the working surface of the lateral detector is adjustably set. Likewise, the angle of the working surface of the transverse detector is adjustable, so that the SPECT imaging system of the embodiments of the present invention selectively acquires photon detection images at more angles. Through adjusting the angle of the working face of the transverse detector, the gap coverage left at the included angle of the adjacent detectors can be realized, and the clinical scanning of the human body cut-off of the bed can be maximally realized without changing any rotation angle.

In other embodiments, the angle of the working surface of the lateral detector is fixed. Or the angle of the working surface of the longitudinal detector is fixed.

A high sensitivity collimator is optionally mounted in the four detectors. In the reconstruction algorithm, different weights are used for the data of different detectors, so that a low noise image or a high resolution image is acquired for different clinical needs. According to the SPECT imaging system provided by the embodiment of the invention, the data weights of the collimators with different resolutions are automatically adjusted by aiming at different imaging requirements of different organs, so that the balance of the visual field, the sensitivity and the resolution is achieved.

In some embodiments, as shown in FIG. 6, the projected points of the center of rotation on the left and right lateral detectors are 16.72mm,33.33mm, respectively, from the left and right lateral detector centerlines, which do not change with angle changes.

As shown in fig. 8, the present invention further provides a SPECT imaging system, including the SPECT imaging device and a control system, where the control system includes:

In some embodiments, the control system further comprises a swipe module. The compensation module is used for checking the scanning effect, the scanning effect comprises scanning completion degree and resolution, the compensation module is also used for judging whether to carry out compensation scanning according to the checking result and determining a compensation scanning angle and a compensation scanning distance according to the checking result, and the compensation scanning module is configured to control the detection module to carry out compensation scanning. According to the SPECT imaging system, the compensation module is arranged to perform compensation when the need of compensation is determined, and the compensation angle and the compensation distance are determined according to the checking result during compensation, so that omnibearing scanning can be avoided, and the efficiency is further improved.

The control system further includes a reset module. The reset module is used for moving the detector to the maximum outer diameter and controlling the frame to rotate to the 0-degree position.

The invention also provides a diagnostic combination comprising the SPECT imaging system and a SPECT diagnostic drug.

The following illustrates an example of clinical testing using diagnostic combinations of embodiments of the present invention.

The patient has a height of 184cm, a weight of 85kg, an arm lifting, a shoulder widest part of about 410mm and a chest thickness of about 250mm.

At the time of detection, referring to fig. 8,

After the SPECT system is powered on, the main control and image processing computer is started automatically, a user or an operation technician can select a patient to perform preregistration, register patient information to be checked in advance, register the patient, register basic information of the patient on site, and perform SPECT scanning data acquisition formally.

Firstly, starting a self-checking module, selecting a corresponding visceral organ protocol and a body position bed entering mode, entering a system checking interface, collecting different protocols such as static scanning, clicking a parameter interface of the protocols, setting the type of an installed collimator such as high-energy universal energy window combination, and information such as the type of nuclide injected by a patient such as Tc-99m, injection time, injection dosage and the like.

Then the detection module is started, the starting angle to the ending angle of the SPECT frame rotation is set, the approaching mode of the detector is set, for example, the FD mode (Fixed Distance) is defined as the Fixed Distance between the detector and the human body contour, for example, 10-180 mm, the AB mode (As close as possible to body) is the nearest Distance between the detector and the human body contour, for example, 2-10mm, the starting position to the ending position of the feeding bed is set, the moving bed button is executed to send the patient to the scanning bed, the scanning is started by clicking, the SPECT frame rotates to the set angle, the detector moves to the set Distance, if the variable angle exists, the detector swings to the set angle, for example, 0-30 degrees, the speed above can be configured through the lower computer firmware, and finally the SPECT acquisition is stopped or ended according to different counting modes, for example, the time count, the total event count or the gate count.

And if the acquisition is finished, judging whether the scanning angle needs to be supplemented according to the scanning effect. The detection module can be called to rescan by starting the compensation module or the data obtained by automatically compensating the missing angle according to the dynamic acquisition is enough to be acquired.

And finally, automatically executing a reset state by the lower computer through a reset module, firstly moving the detector to the position of the maximum outer diameter, and then rotating the SPECT rack to the set 0-degree position.

By using the SPECT imaging system, the total detection time is 15 minutes, the integration and intelligent degree is high compared with the traditional equipment, the operation is more convenient, the fitting degree with the outline of a patient is better, the total detection time is effectively reduced by comprehensively intelligently judging the supplementary scanning module, the use of SPECT diagnosis medicines is reduced, and the burden of the patient is effectively reduced.

It should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the specific embodiments of the present invention may be modified or some technical features may be equivalently replaced, and they are all included in the scope of the technical solution of the present invention as claimed.

Claims

1. A SPECT imaging device, comprising:

A frame (12), the frame (12) having a through hole for passing a subject to be inspected, the through hole having a central axis, and

The nuclear detector group (20) is arranged on the end face of the frame (12), the nuclear detector group (20) comprises a first longitudinal detector (21) and a second longitudinal detector (22) which are respectively arranged on the upper side and the lower side of the central axis, and a first transverse detector (23) and a second transverse detector (24) which are respectively arranged on the left side and the right side of the central axis, the first longitudinal detector (21) and the second longitudinal detector (22) are used for acquiring longitudinal images of detected objects, the first transverse detector (23) and the second transverse detector (24) are used for acquiring transverse images of detected objects, an included angle is formed between the first longitudinal detector (21) and the second longitudinal detector (22), and an included angle is formed between the first transverse detector (23) and the second transverse detector (24) so that the nuclear detector group forms an irregular quadrilateral.

2. The SPECT imaging device of claim 1 wherein a distance between the longitudinal detector and the central axis is less than a distance between the lateral detector and the central axis.

3. SPECT imaging device according to claim 1, characterized in that the longitudinal detector covers a scanning range which is larger than the scanning range covered by the transverse detector in the circumferential direction of the distribution of the nuclear detector groups (20), so that the gantry (12) is not rotated or is rotated by less than 90 ° around the central axis for an omnidirectional examination of the object under examination.

4. The SPECT imaging device of any of claims 1 to 3 wherein the longitudinal detector is configured to be movably disposed in a radial direction to be proximate to the detected object and/or the transverse detector is configured to be movably disposed in a radial direction to be proximate to the detected object.

5. SPECT imaging device according to any of claims 1 to 4, characterized in that the working face of the first longitudinal detector (21) is arranged parallel or inclined with respect to a transverse axis (x) with which the working face of the second longitudinal detector (22) is parallel, the transverse axis (x) extending perpendicularly to the central axis and in a transverse direction.

6. SPECT imaging device according to claim 5, characterized in that the angle (a) between the working face of the first longitudinal detector (21) and the working face of the second longitudinal detector (22) is 0 ° to 60 °, preferably 0 ° to 30 °.

7. SPECT imaging device according to any of claims 1 to 6, characterized in that the working face of the first transverse detector (23) is arranged parallel or obliquely with respect to a longitudinal axis (y), and the working face of the second transverse detector (24) is arranged obliquely with respect to a longitudinal axis (y), which longitudinal axis (y) runs perpendicular to the central axis and in the longitudinal direction.

8. SPECT imaging device according to claim 7, characterized in that the angle (β) between the working face of the first transverse detector (23) and the working face of the second transverse detector (24) is 0 ° to 60 °, preferably 0 ° to 30 °.

9. SPECT imaging device according to any of claims 1 to 8, characterized in that the working surface of the first longitudinal detector (21) is arranged obliquely with respect to a transverse axis, the working surface of the second longitudinal detector (22) is arranged obliquely with respect to the transverse axis (x), the working surface of the first transverse detector (23) is arranged obliquely with respect to a longitudinal axis (y), wherein the working surface of the second transverse detector (24) is arranged obliquely with respect to the longitudinal axis (y), the longitudinal axis, the transverse axis and the central axis being perpendicular to each other.

10. The SPECT imaging device of any of claims 1 to 9 wherein the angle of the working face of the longitudinal detector is adjustably set or the angle of the working face of the transverse detector is adjustably set.

11. The SPECT imaging device according to any of the claims 1 to 10, wherein the detector of the core detector group (20) comprises a large area sodium iodide (NaI) continuous crystal or a regular volume cesium iodide (Csl) crystal, or the detector of the core detector group (20) comprises a sodium iodide crystal and a coupled photo-device, which is arranged in a fitting manner on the back side of the sodium iodide crystal, which comprises a photomultiplier tube (PMT) array or a silicon photomultiplier tube, or the detector of the core detector group (20) comprises a cesium iodide crystal and a coupled photo-device, which is arranged in a fitting manner on the back side of the cesium iodide crystal, which comprises a photomultiplier tube (PMT) array or a silicon photomultiplier tube.

12. The SPECT imaging device according to any of claims 1 to 11 wherein the ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3): (1-2), preferably (1.5-2.5): 1, and/or wherein the longitudinal detector comprises a longitudinal probe array arranged in a manner of (4-16) × (4-16), preferably in a manner of (8-12) × (8-12), and/or wherein the transverse detector comprises a transverse probe array arranged in a manner of (6-10) × (6-10).

13. SPECT imaging device according to any of claims 1 to 12, characterized in that the distance between the detector of the nuclear detector group (20) and the object to be detected is 2 to 250mm, preferably 2 to 10mm or 10 to 180mm, or the distance between the projection point of the rotation center on the left-hand lateral detector and the centre line of the right-hand lateral detector is 10 to 25mm,25 to 40mm, respectively, without variation with angle.

14. The SPECT imaging device according to any of claims 1 to 13, characterized in that the gantry (12) is configured to rotate stepwise around the central axis between-30 ° and 30 °, preferably the distance between the detector of the nuclear detector group (20) and the object to be detected is constantly set to 15mm.

15. A SPECT imaging system comprising a SPECT imaging device according to any of claims 1 to 14 and a control system comprising:

The detection module is used for controlling the starting angle and the ending angle of the stand and selecting a fixed position mode or a mode closest to the human body distance, is further configured to control the stand to rotate to a set angle, the detector to move to a set distance, the detector to rotate to the set angle and scan according to a preset scanning mode after scanning starts, and is further configured to determine whether scanning is ended according to a time count or a total event count or a gating count.

16. The SPECT imaging system of claim 15 wherein the control system further includes a replenishment scan module for checking a scan effect including a scan completion level and a resolution, the replenishment scan module further for determining whether to replenish the scan and determining a replenishment scan angle and a replenishment scan distance based on the check result, and the replenishment scan module is configured to control the detection module to replenish the scan, or a reset module for moving the detector to a maximum outer diameter and controlling the gantry to rotate to a 0 ° position.

17. A diagnostic combination comprising the SPECT imaging system of claim 15 or 16 and a SPECT diagnostic drug.

18. The diagnostic combination of claim 17, wherein the SPECT diagnostic drug is administered at a dose of 0.1-1mCi/kg or wherein the diagnostic combination has a single case detection time of 5-60 minutes.

19. The diagnostic combination of claim 18, wherein the SPECT diagnostic drug is administered at a dose of 0.1-0.5mCi/kg, or wherein the diagnostic combination has a single case detection time of one of 5-50 minutes, 5-40 minutes, 5-45 minutes, 10-45 minutes, 15-30 minutes, 15-20 minutes.