CN1192930A - Contrast medium capable of eliminating in-stomach fluid level false shadow in CT scanning and use method thereof - Google Patents
Contrast medium capable of eliminating in-stomach fluid level false shadow in CT scanning and use method thereof Download PDFInfo
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- CN1192930A CN1192930A CN97105723A CN97105723A CN1192930A CN 1192930 A CN1192930 A CN 1192930A CN 97105723 A CN97105723 A CN 97105723A CN 97105723 A CN97105723 A CN 97105723A CN 1192930 A CN1192930 A CN 1192930A
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- acid
- effervescent
- carboxymethyl cellulose
- sodium carboxymethyl
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Abstract
The present invention relates to a contrast medium capable of removing pseudo-image of endogastric juice surface which can be produced in the course of CT stomach scanning and its application method. Said invention is characterized by that firstly, 25-35 ml of citric acid is taken in, then the liquid mixture prepared by using 1.7-2.5g of NaHCO3 and 8-12g of carboxymethylcellulose sodium and adding 300 ml of water is taken in, so that it can radically removing pseudo-image on the endogastric juice surface, therefore it is favourable for CT diagnosis.
Description
The present invention relates to the CT abdomen examination and eliminate the contrast agent and the using method of in-stomach fluid level.
In the epigastrium CT scan, diagnosis brings considerable influence to CT from the pseudo-shadow of stomach, and its reason mainly contains two, one, the wriggling of stomach, the 2nd, gastric gas-liquid face.For the former, mostly adopt the spasmolytic medicine, its effect gains public acceptance, for the latter, still there is not good solution at present both at home and abroad, adopt rare iodine liquid, rare barium liquid, water preparation, oil preparation no matter be, because of there are a fluid level in oral these contrast agent and gastric gas, the two always exists greater density poor, strip artifact usually occurs, and diagnosis brings influence to CT.
The purpose of this invention is to provide a kind of contrast agent and the using method that can eliminate the CT scan in-stomach fluid level false shadow, thereby be beneficial to the CT diagnosis.
The present invention eliminates the contrast agent of in-stomach fluid level false shadow and is made up of two kinds of components, and a kind of is medical acid effervescent solution, and a kind of is the mixed liquor of alkaline effervescent and solid infusion.
Acid effervescent such as citric acid, lactic acid, Phenyl Acetic Acid (Powder, alkaline effervescent such as NaHCO
3Gu, infusion such as sodium carboxymethyl cellulose.
The key that the present invention eliminates pseudo-shadow is to eliminate gastric gas-liquid face, selects citric acid, NaHCO for use
3Deng making effervescent, sodium carboxymethyl cellulose etc. are solid infusion, and select suitable using method, make it to produce bubble, upwards slowly rise, because the sodium carboxymethyl cellulose viscosity is big from the stomach bottom at gastric, the bubble of rising does not break rapidly, form the density contrast that successively decreases gradually from top to bottom, do not form the fluid level, fundamentally reach the purpose of eliminating pseudo-shadow.
Citric acid, sodium bicarbonate, sodium carboxymethyl cellulose are widely used in clinical and pharmacy industry, all have no side effect, and have not been applied to CT examination, are usually used in the low double contrast radiograph inspection of gastrointestinal, with barium agent use in conjunction, can produce dual contrast effect.Application requirements in this respect produces more gas, and does not wish to have bubble, and the present invention wishes that bubble constantly produces, and can retain the long period.The present invention has obtained solution by instructions of taking and the consumption that increases solid infusion such as sodium carboxymethyl cellulose.Each component dose is: citric acid 25～35ml of 7.5%, the NaHCO of 1.7～2.5g
3Add water 300ml formation mixed liquor with the sodium carboxymethyl cellulose of 8～12g.Using method is: take acid effervescent earlier, take the mixed liquor of alkaline effervescent and solid infusion then.
The present invention illustrates by following test,
Elder generation pours 7.5% citric acid 30ml in the glass into, and then pour 2g sodium bicarbonate and the 10g sodium carboxymethyl cellulose mixed liquor 300ml that stirs evenly into, see because the sodium carboxymethyl cellulose fluid viscosity is bigger, bubble produces slowly rising of back at the bottom of cup, the not rapid carbon of bubble that rises to the surface splits, form a bubble band, it is thin more more up to steep wall, does not form liquid level.To the trier scanning, density lowers from bottom to top gradually, and no liquid level forms.Reach the purpose of basic elimination liquid level.Result to above-mentioned experimental observation bubble generation and extinction time is as follows.Promptly be carved with bubble after two kinds of solution contacts and produce, but negligible amounts, liquid level still exists; 30 seconds to 5 minutes, bubble produced in a large number, and to the surperficial density contrast that demonstrates from high to low, liquid level disappears from the bottom.Though still there was bubble on the upper strata in 6～8 minutes, quantity obviously reduces, and liquid level forms gradually, liquid level can occur after 10 minutes.Be not difficult to find out 30 "～5 ' produce bubble at most, for eliminating the liquid level Best Times.
Below be contrast test:
Random inspection 120 routine epigastrium CT scan patients are as matched group, and (water 300～500ml) persons 86 examples, (300～500ml water adds 60% cardiografin, 5～6ml) persons, 34 examples to clothes high density contrast agent to oral low-density contrast medium before the scanning.Test group 120 examples are taken (also be called low-density contrast medium, connect component and the amount taked in the above-mentioned test) by the present invention before the 80 example scannings, and (the present invention adds 60% cardiografin 5～6ml) to 40 example clothes high density contrast agent more in addition.
Observe: (1) two group of clothes are low, pseudo-shadow situation appears in the high density contrast agent.(2) observe in-stomach fluid level disappearance situation.Evaluate according to two groups of patient's CT examination photos, do not have liquid level, no pseudo-shadow or slight pseudo-shadow occurs but do not influence being diagnosed as excellent.Liquid level and pseudo-shadow occur, influence is diagnosed as poor sheet.Matched group and test group case all use West Germany SOMATOM CR whole body CT machine check, scanning all to inject 654-2 in preceding 15～20 minutes, 20mg, and patient lies on the back, and holds one's breath 5 seconds sweep times, bed thickness 8mm, window width 250Hu, window position 30Hu during scanning.
The result:
1, pseudo-shadow person 35 examples appear in matched group clothes low-density contrast medium 86 examples, and pseudo-shadow person 18 examples appear in clothes high density contrast agent person 34 examples.Statistical procedures, P＞0.05, the two differs not remarkable.2, pseudo-shadow appears in test group 80 example clothes low-density contrast medium persons 1 example, and pseudo-shadow appears in 40 example clothes high density radiography persons, 1 example, learns by statistics and handles P＞0.05.3, in-stomach fluid level elimination situation is relatively pressed last commentary sheet standard, excellent 67 of matched group, and difference sheet 53, excellent 118 of test group, difference sheet 2 is learned by statistics and is handled, and the two has significant differences P＜0.01.
Though test group has two examples that pseudo-shadow is arranged, through observing, there is not liquid level in gastric, pseudo-shadow also be not from the gas-liquid intersection produce radial, but having by the more gas coat of the stomach, limitation, consider that the spasmolytic effect is not good enough owing to individual variation, coat of the stomach little wriggling occurs and causes.Like this, eliminate situation with regard to in-stomach fluid level, 120 routine patients all reach promising result, because selected medicine, using method can fundamentally be eliminated liquid level, are confirmed by test.
In test group 120 examples,, observe all photos, the two is compared, find that in-stomach fluid level all disappears, also do not produce pseudo-shadow even therefore add cardiografin in the contrast agent of the present invention though there are 40 examples to add cardiografins 5～6ml.Can select to use according to patient's different situations.
The bubble of the present invention back of breaking produces more gas, builds up the front portion in stomach, and according to observations, what of gas do not have obvious influence to quality of scanning.
30 seconds to 5 minutes bubbles produce in a large number after taking contrast agent of the present invention, for eliminating the Best Times of liquid level.
Advantage of the present invention: routine application verification surplus laboratory research and clinical 400, fundamentally eliminated the gastric fluid level, pseudo-shadow does not appear in CT examination, helps the CT diagnosis.
Again for several embodiment:
Embodiment one:
Citric acid 25ml adds the NaHCO that water 300ml stirs evenly
31.7g with sodium carboxymethyl cellulose 8g, by using method of the present invention, scanning all reaches the pseudo-effect that disappears at once.
Embodiment two:
Citric acid 35ml adds the NaHCO that water 300ml stirs evenly
32.5g with sodium carboxymethyl cellulose 12g, by using method of the present invention.
Embodiment three:
Citric acid 28ml adds the NaHCO that water 300ml stirs evenly
31.8g with sodium carboxymethyl cellulose 11g, by using method of the present invention.
Claims (7)
1, a kind of contrast agent that can eliminate the CT scan in-stomach fluid level false shadow is characterized in that being made up of two kinds of components, and a kind of is medical acid effervescent, and a kind of is the mixed liquor of alkaline effervescent and solid infusion.
2, contrast agent according to claim 1 is characterised in that described acid effervescent can be citric acid, lactic acid, Phenyl Acetic Acid (Powder, and alkaline effervescent is NaHCO
3Gu infusion is a sodium carboxymethyl cellulose.
3, according to claim 1,2 described contrast agent, being characterised in that needs citric acid 25～35ml of 7.5%, the NaHCO of 1.7～2.5g
3Add water 300ml formation mixed liquor with the sodium carboxymethyl cellulose of 8～12g.
4, a kind of method of using the described contrast agent of claim 1 is characterized in that taking earlier medical acid effervescent, takes the mixed liquor of alkaline effervescent and solid infusion then.
5, method according to claim 4 is characterised in that described acid effervescent can be citric acid, lactic acid, Phenyl Acetic Acid (Powder, and alkaline effervescent is NaHCO
3Gu infusion is a sodium carboxymethyl cellulose.
6, according to claim 4,5 described methods, being characterised in that needs citric acid 25～35ml of 7.5%, the NaHCO of 1.7～2.5g
3Add water 300ml formation mixed liquor with the sodium carboxymethyl cellulose of 8～12g.
7, method according to claim 6, being characterised in that takes medicine is the CT scan Best Times in back 30 seconds to 5 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105723A CN1072019C (en) | 1997-03-11 | 1997-03-11 | Contrast medium capable of eliminating in-stomach fluid level false shadow in CT scanning and use method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105723A CN1072019C (en) | 1997-03-11 | 1997-03-11 | Contrast medium capable of eliminating in-stomach fluid level false shadow in CT scanning and use method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1192930A true CN1192930A (en) | 1998-09-16 |
| CN1072019C CN1072019C (en) | 2001-10-03 |
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| CN97105723A Expired - Fee Related CN1072019C (en) | 1997-03-11 | 1997-03-11 | Contrast medium capable of eliminating in-stomach fluid level false shadow in CT scanning and use method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7003345B1 (en) * | 2000-10-17 | 2006-02-21 | Lucid, Inc. | System and method for enhancing microscope images of tissue using citric acid and agents of the like |
| US7139122B1 (en) | 2000-10-17 | 2006-11-21 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
| CN113069129A (en) * | 2021-02-26 | 2021-07-06 | 四川省肿瘤医院 | Method for removing intragastric artifacts in 18F-FDG PET/CT examination |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101487836B (en) * | 2009-02-06 | 2012-03-28 | 煤炭科学研究总院重庆研究院 | Coal and gas outburst test simulation ground stress device |
| CN101487834B (en) * | 2009-02-06 | 2012-03-28 | 煤炭科学研究总院重庆研究院 | Coal and gas outburst comprehensive test device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487757A (en) * | 1981-12-28 | 1984-12-11 | Colgate-Palmolive Company | Dispensing container of toothpaste which effervesces during toothbrushing |
| JPH0747534B2 (en) * | 1986-06-02 | 1995-05-24 | ロ−ラ−ジヤパン株式会社 | Tablets |
-
1997
- 1997-03-11 CN CN97105723A patent/CN1072019C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7003345B1 (en) * | 2000-10-17 | 2006-02-21 | Lucid, Inc. | System and method for enhancing microscope images of tissue using citric acid and agents of the like |
| US7139122B1 (en) | 2000-10-17 | 2006-11-21 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
| US7676258B2 (en) | 2000-10-17 | 2010-03-09 | Lucid, Inc. | System and method for enhancing microscopic images of tissue |
| CN113069129A (en) * | 2021-02-26 | 2021-07-06 | 四川省肿瘤医院 | Method for removing intragastric artifacts in 18F-FDG PET/CT examination |
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| Publication number | Publication date |
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| CN1072019C (en) | 2001-10-03 |
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