CN119279088A - A kind of intelligent release feed additive and its preparation method and application - Google Patents
A kind of intelligent release feed additive and its preparation method and application Download PDFInfo
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 241000283690 Bos taurus Species 0.000 claims abstract description 76
- 235000015278 beef Nutrition 0.000 claims abstract description 65
- 239000002245 particle Substances 0.000 claims abstract description 49
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- WVTKBKWTSCPRNU-KYJUHHDHSA-N (+)-Tetrandrine Chemical compound C([C@H]1C=2C=C(C(=CC=2CCN1C)OC)O1)C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@@H]2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-KYJUHHDHSA-N 0.000 claims abstract description 42
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- WVTKBKWTSCPRNU-UHFFFAOYSA-N rac-Tetrandrin Natural products O1C(C(=CC=2CCN3C)OC)=CC=2C3CC(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2CC2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-UHFFFAOYSA-N 0.000 claims abstract description 21
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Abstract
The application relates to the technical field of livestock breeding, and particularly discloses an intelligent release type feed additive and a preparation method and application thereof. The intelligent release type feed additive comprises nutrition particles, and a slow release layer and an acid-base buffer layer which are sequentially coated on the outer surfaces of the nutrition particles, wherein the slow release layer is one or more selected from cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4) -2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate, and the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide with the weight ratio of 1 (0.17-0.36). The intelligent release type feed additive provided by the application can respond to the acid-base environment in the intestines and stomach of beef cattle in real time, intelligently release nutrient substances, effectively maintain the health of the digestive system of the beef cattle, and improve the growth performance and feed conversion of the beef cattle, so that the overall benefit of feeding is improved.
Description
Technical Field
The application relates to the technical field of livestock breeding, in particular to an intelligent release type feed additive and a preparation method and application thereof.
Background
Beef cattle raising industry faces multiple challenges such as digestion efficiency improvement, nutrition accurate matching in growth stage, health maintenance of digestive system and the like. The traditional feed additive is mostly a nutrient component mixture with a fixed proportion, and cannot be intelligently adjusted according to the digestion process of beef cattle, so that part of nutrient components are wasted in the digestion process, and meanwhile, the beef cattle can be possibly caused to have insufficient nutrition in certain digestion stages.
In recent years, some intelligent feed additives are appeared on the market, and most of the feed additives are only improved aiming at a single function, for example, the feed additives are concentrated on the adjustment of intestinal microecology, and the nutritional ingredients cannot be dynamically released according to the pH value change in the digestion process of beef cattle, so that the popularization of the products in practical application is limited.
Therefore, the beef cattle raising industry is urgently required to be provided with an intelligent novel feed additive, the acid-base environment in the intestines and stomach of the beef cattle can be responded in real time, the nutrient substances can be intelligently released, the health of the digestive system of the beef cattle can be effectively maintained, and accordingly the overall benefit of beef cattle raising is improved.
Disclosure of Invention
The application provides an intelligent release type feed additive, a preparation method and application thereof, and aims to solve the problem that the existing feed additive can not carry out intelligent nutrient component release adjustment according to the digestion process of beef cattle.
In a first aspect, the intelligent release type feed additive provided by the application adopts the following technical scheme:
an intelligent release type feed additive comprises nutrition particles, a slow release layer and an acid-base buffer layer which are sequentially coated on the outer surfaces of the nutrition particles;
the slow release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4) -2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate;
The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide with a weight ratio of 1 (0.17-0.36).
The application provides an intelligent release type feed additive with a double-layer coating, which can intelligently adjust the acidity and alkalinity in the environment and release nutrient components according to the pH value change in the digestion process of beef cattle, prevent the nutrition particles from losing efficacy due to chemical change under the condition of peracid or over-alkali, improve the utilization rate of the nutrition particles in animal digestive tracts, and further improve the growth performance and health state of animals. The acid-base buffer layer adopts sodium bicarbonate and magnesium oxide in a specific proportion, so that the pH value of the microenvironment can be regulated after the feed additive enters the intestines and stomach of the beef cattle, and favorable conditions are provided for releasing the feed additive. The slow release layer material adopts a pH sensitive release material, and the material can slowly dissolve and release internal nutrient substances only under the slightly acidic or neutral condition, so that the internal feed additive can be gradually released under the proper condition, the beef cattle can fully absorb the nutrient substances, and the waste of the nutrient substances is avoided. Therefore, the double-layer coated intelligent release type feed additive provided by the application can intelligently regulate the gastrointestinal acidity and alkalinity of animals and release nutrient substances under proper conditions, thereby ensuring the utilization rate of the nutrient substances, improving the feed conversion ratio of the animals and improving the growth performance and the health state.
In the application, sodium bicarbonate and magnesium oxide are used as acid slow-down substances, so that the acid of feed and organic acid generated by rumen microorganisms can be neutralized, thereby maintaining the stability of rumen pH value, further facilitating the digestion of cellulose and other saccharides in the feed, improving the feed conversion rate and improving the feed conversion rate, and in addition, the acid slow-down substances can release a certain nutrient substance after stabilizing the pH value of the rumen in neutrality, improve the growth performance and health state of animals and improve the culture benefit.
Optionally, the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1 (0.21-0.32).
In some embodiments, the weight ratio of sodium bicarbonate to magnesium oxide may be 1：(0.17-0.21)、1：(0.17-0.27)、1：(0.17-0.32)、1：(0.17-0.36)、1：(0.21-0.27)、1：(0.21-0.32)、1：(0.21-0.36)、1：(0.27-0.32)、1：(0.27-0.36) or 1 (0.32-0.36).
In a specific embodiment, the weight ratio of sodium bicarbonate to magnesium oxide may also be 1:0.17, 1:0.21, 1:0.27, 1:0.32, or 1:0.36.
Optionally, the slow release layer is a mixture of cellulose acetate phthalate and tetrandrine.
Optionally, the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.1-0.5).
According to the application, through experimental investigation, the mixture of the cellulose acetate phthalate and the tetrandrine is further adopted as a slow-release material, and the weight ratio of the cellulose acetate phthalate and the tetrandrine is controlled within the range, so that the beef cattle can absorb the nutrient substances more fully, and the production performance of the beef cattle is high.
Optionally, the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.2-0.4).
In some embodiments, the weight ratio of cellulose acetate phthalate to tetrandrine may be 1：(0.1-0.2)、1：(0.1-0.3)、1：(0.1-0.4)、1：(0.1-0.5)、1：(0.2-0.3)、1：(0.2-0.4)、1：(0.2-0.5)、1：(0.3-0.4)、1：(0.3-0.5) or 1 (0.4-0.5).
In a specific embodiment, the weight ratio of cellulose acetate phthalate to tetrandrine may also be 1:0.1, 1:0.2, 1:0.3, 1:0.4 or 1:0.5.
Optionally, the nutritional granules comprise 1-2 parts by weight of amino acid, 1-2 parts by weight of mineral and 0.5-0.8 part by weight of vitamin.
Optionally, the weight ratio of the nutrition particles to the slow release layer to the acid-base buffer layer is 5 (0.3-1) to 0.3-1.
In some embodiments, the nutritional particles, the slow release layer, and the acid-base buffer layer may be present in a weight ratio of 5：(0.3-0.5)：0.8、5：(0.3-0.8)：0.8、5：(0.3-1)：0.8、5：(0.5-0.8)：0.8、5：(0.5-1)：0.8、5：(0.8-1)：0.8、5：0.8：(0.3-0.5)、5：0.8：(0.3-0.8)、5：0.8：(0.3-1)、5：0.8：(0.5-0.8)、5：0.8：(0.5-1) or 5:0.8 (0.8-1).
In a specific embodiment, the weight ratio of the nutritional particles, the slow release layer, and the acid-base buffer layer may also be 5:0.3:0.8, 5:0.5:0.8, 5:0.8:0.8, 5:1:0.8, 5:0.8:0.3, 5:0.8:0.5, or 5:0.8:1.
In a second aspect, the application provides a method for preparing an intelligent release type feed additive.
A preparation method of the intelligent release type feed additive comprises the following steps of uniformly mixing all components of nutrition particles, granulating to obtain nutrition particles, spraying the surfaces of the nutrition particles to be wet, then mixing with slow release layer materials, uniformly shaking to enable the surfaces of the nutrition particles to be fully wrapped with the slow release layer materials to obtain prefabricated particles, continuously spraying the surfaces of the prefabricated particles to be wet, mixing with acid-base buffer layer materials, and uniformly shaking to enable the surfaces of the prefabricated particles to be fully wrapped with the acid-base buffer layer materials to obtain the intelligent release type feed additive.
In a third aspect, the present application provides the use of an intelligent release feed additive in animal feed.
A beef cattle feed comprises the intelligent release type feed additive, wherein the weight ratio of the intelligent release type feed additive to the beef cattle feed is 1.5-2.5g/kg.
In summary, the application has the following beneficial effects:
1. The intelligent release type feed additive is prepared from the nutrition particles, the slow release layer and the acid-base buffer layer, can intelligently regulate the pH value change of intestines and stomach in the digestion process of beef cattle and release nutrient substances under proper conditions, so that the beef cattle can fully absorb the nutrient substances, the feed conversion ratio is improved, the growth performance and the health state are improved, the cultivation benefit of a farm is further improved, and the intelligent release type feed additive has good economic value and application prospect.
2. The application adopts sodium bicarbonate and magnesium oxide with the weight ratio of 1 (0.17-0.36) as an acid-base buffer layer, adopts cellulose acetate phthalate and tetrandrine with the weight ratio of 1 (0.2-0.4) as a slow release layer, and controls the weight ratio of nutrition particles, the slow release layer and the acid-base buffer layer to be 5 (0.3-1), and the prepared intelligent release type feed additive has good growth promotion effect on beef cattle, so that the growth performance of the beef cattle is good.
Detailed Description
The application provides an intelligent release type feed additive which comprises nutrition particles, and a slow release layer and an acid-base buffer layer which are sequentially coated on the outer surfaces of the nutrition particles, wherein the weight ratio of the nutrition particles to the slow release layer to the acid-base buffer layer is (0.3-1) to (0.3-1). The nutritional granules comprise, by weight, 1-2 parts of amino acids, 1-2 parts of minerals and 0.5-0.8 part of vitamins. The slow release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4) -2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate. The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide with a weight ratio of 1 (0.17-0.36).
Further, the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide with a weight ratio of 1 (0.21-0.32). The slow release layer is a mixture of cellulose acetate phthalate and tetrandrine, and the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.1-0.5). Still further, the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.2-0.4).
The preparation method of the intelligent release type feed additive provided by the application comprises the following steps:
The method comprises the steps of uniformly mixing all the components of the nutrition particles, granulating to obtain nutrition particles, spraying moisture on the surfaces of the nutrition particles, mixing with a slow-release layer material, uniformly shaking to enable the surfaces of the nutrition particles to be fully coated with the slow-release layer material to obtain prefabricated particles, continuously spraying moisture on the surfaces of the prefabricated particles, mixing with an acid-base buffer layer material, and uniformly shaking to enable the surfaces of the prefabricated particles to be fully coated with the acid-base buffer layer material to obtain the intelligent release type feed additive.
In the application, the cellulose acetate phthalate is purchased from merck, CAS number is 9004-38-0, tetrandrine is purchased from Shanxi Xintian biosciences, hydroxypropyl methylcellulose phthalate is HPMCP-H55, is purchased from Shandong Living biosciences, sodium bicarbonate is food grade, is purchased from Jiangsu jia biosciences, and magnesium oxide is feed grade, is purchased from Shandong Gu biosciences. The raw materials, reagents, solvents, etc. of the application are all commercially available.
The present application will be described in further detail with reference to examples and performance test.
Examples 1 to 5
Examples 1-5 provide an intelligent release feed additive, respectively.
The difference between the above examples is that the proportion of sodium bicarbonate and magnesium oxide in the acid-base buffer layer of the intelligent release type feed additive is shown in the following table 1.
The preparation method of the intelligent release type feed additive provided in the embodiments 1-5 comprises the following steps:
(1) Firstly, weighing 15kg of amino acid, 15kg of mineral substances and 7kg of vitamins, mixing, spraying water for a small amount of times while stirring until the mixture can be kneaded into a ball without moist feel, then pouring the mixture into a granulator for extrusion granulation, and screening to obtain nutrition granules with the particle size of 5+/-2 mm.
Sodium bicarbonate and magnesium oxide are uniformly mixed according to the weight ratio shown in table 1, and an acid-base buffer layer material is obtained.
Uniformly mixing the cellulose acetate phthalate and the tetrandrine according to the weight ratio of 1:0.3 to obtain the slow-release layer material.
(2) Respectively taking 500g of nutrition particles, 80g of acid-base buffer layer material and 80g of slow release layer material, spraying the surfaces of the nutrition particles to wet, then mixing with the slow release layer material and uniformly shaking to ensure that the surfaces of the nutrition particles are fully coated with the slow release layer material to obtain prefabricated particles, continuously spraying the surfaces of the prefabricated particles to wet, mixing with the acid-base buffer layer material and uniformly shaking to ensure that the surfaces of the prefabricated particles are fully coated with the acid-base buffer layer material to obtain the intelligent release type feed additive.
Table 1 ratio of sodium bicarbonate to magnesium oxide in acid-base buffer layers of examples 1 to 5
| Examples | Weight ratio of sodium bicarbonate to magnesium oxide |
| 1 | 1:0.17 |
| 2 | 1:0.21 |
| 3 | 1:0.27 |
| 4 | 1:0.32 |
| 5 | 1:0.36 |
Examples 6 to 11
Examples 6-11 each provide an intelligent release feed additive.
The difference between the above examples and example 3 is the composition and proportion of the material of the slow release layer of the intelligent release type feed additive, specifically shown in table 2 below.
TABLE 2 Components and proportions of the sustained-release layer materials of example 3 and examples 6 to 11
Examples 12 to 18
Examples 12-18 each provide an intelligent release feed additive.
The above examples differ from example 3 in the weight ratio of the nutritional particles, the slow release layer and the acid-base buffer layer, as shown in Table 3 below. 500g of nutritional granules, 80g of material and 80g of material
TABLE 3 weight ratio of nutrient particles, sustained release layer and acid-base buffer layer in example 3, examples 12-18
Comparative example 1
Comparative example 1 provides an intelligent release feed additive.
The above comparative example is different from example 3 in that only sodium bicarbonate was used for the acid-base buffer layer.
Comparative example 2
Comparative example 2 provides an intelligent release feed additive.
The above comparative example is different from example 3 in that only magnesium oxide is used for the acid-base buffer layer.
Comparative example 3
Comparative example 3 provides an intelligent release feed additive.
The comparative example differs from example 3 in that the weight ratio of sodium bicarbonate to magnesium oxide is 1:1.
Comparative example 4
Comparative example 4 provides an intelligent release feed additive.
The above comparative example is different from example 3 in that the intelligent release feed additive does not include an acid-base buffer layer.
Comparative example 5
Comparative example 5 provides an intelligent release feed additive.
The above comparative example differs from example 3 in that the intelligent release feed additive does not include a buffer layer.
Performance test the intelligent release type feed additives obtained in examples 1 to 18 and comparative examples 1 to 5 were subjected to performance test, and the results are shown in table 4 below.
(1) The compound feed additive is added into common feed (purchased from Beijing Jia He Mufeng feed Co., ltd.) according to the addition amount of 2g/kg, and the mixture is uniformly mixed to obtain the beef cattle feed.
(2) Selecting 120 Sigata cattle at 12 months of age, and randomly dividing the Sigata cattle into 24 groups of 5 heads;
Feeding management, wherein 18 groups are respectively fed with beef cattle feed provided in examples 1-18, 5 groups are respectively fed with beef cattle feed provided in comparative examples 1-5, 1 group is fed with common feed (used as a blank control group), the test period is 30 days, and during the test period, single-trough feeding is respectively carried out, 2 times a day, free feeding and drinking water are carried out, and all conditions are basically consistent.
The test detection comprises weighing the empty weight of each cow before the test, recording the feed intake of each group of beef cattle daily in detail during the test, and weighing the empty weight of each cow after the test. The average daily gain, average daily feed intake and feed/meat ratio of each beef cattle were comprehensively calculated, and the results are shown in the following table 4.
Average daily gain per cow = (average weight per cow test end per group-average weight per cow start per group)/150
Average daily feed intake per cow = 30 days feed consumption per group of cows/150
Feed to meat ratio = average daily feed intake per cow/average daily gain per cow.
Table 4 test results of beef cattle feeding trial
As can be seen from the results of the examination in Table 4, the beef cattle feed obtained in examples 1 to 18 and comparative examples 1 to 5 and the commercial beef cattle feed were used for 30d feeding of beef cattle, the average daily gain of the beef cattle fed in examples 1 to 18 was 1.42 to 1.66 kg/head, the feed conversion ratio was 7.12 to 8.11, and the average daily gain of the beef cattle fed in comparative examples 1 to 5 and the commercial beef cattle fed in commercial was 0.86 to 1.31 kg/head, and the feed conversion ratio was 8.63 to 9.78. It is apparent that the average daily gain of the beef cattle fed in examples 1-18 is significantly higher than the average daily gain of the beef cattle fed in comparative examples 1-5 and commercial beef cattle, and that the feed to meat ratio of the beef cattle fed in examples 1-18 is significantly lower than the feed to meat ratio of the beef cattle fed in comparative examples 1-5 and commercial beef cattle. Therefore, the intelligent release type feed additive provided by the application can intelligently regulate the pH value change of intestines and stomach in the digestion process of beef cattle and release nutrient substances under proper conditions, so that the beef cattle can fully absorb the nutrient substances, the feed conversion ratio is improved, the growth performance and the health state are improved, the cultivation benefit of a farm is further increased, and the intelligent release type feed additive has good economic value and application prospect.
As is clear from the detection results of examples 1 to 5 and comparative examples 1 to 3, the average daily gain of beef cattle fed with the beef cattle feed obtained in examples 1 to 5 was 1.47 to 1.66 kg/head, the feed/meat ratio was 7.29 to 7.62, while the average daily gain of beef cattle fed with the beef cattle feed obtained in comparative examples 1 to 3 was only 1.03 to 1.31 kg/head, and the feed/meat ratio was as high as 8.63 to 9.13. Therefore, the application adopts sodium bicarbonate and magnesium oxide as acid-base buffer layers, the weight ratio of the sodium bicarbonate and the magnesium oxide is controlled within the range of 1 (0.17-0.36), the obtained intelligent release type feed additive has good use effect, and further, the average daily weight gain of beef cattle fed with the beef cattle feed obtained in the examples 2-4 is found to be 1.53-1.66 kg/head, the feed-meat ratio is only 7.29-7.45 (less than or equal to 7.50), and the application further controls the weight ratio of the sodium bicarbonate and the magnesium oxide in the acid-base buffer layers within the range of 1 (0.21-0.32), so that the obtained intelligent release type feed additive has better use effect, and the feed-meat ratio of the obtained beef cattle is higher.
As can be seen from the detection results of examples 3 and 6-11, the average daily gain of beef cattle fed with the beef cattle feed obtained in examples 3 and 6-9 is 1.50-1.66 kg/head, the feed meat ratio is 7.20-7.60, while the intelligent release additive prepared in examples 10-11 adopts the mixture of hydroxypropyl methylcellulose phthalate and tetrandrine or the mixture of cellulose acetate phthalate and polyglucosamine (1-4) -2-amino-B-D glucose as the slow release layer material, and the average daily gain of beef cattle fed with the beef cattle feed obtained in examples 3 and 6-9 is only 1.42-1.45 kg/head, and the feed meat ratio is 7.93-8.03.
As can be seen from the detection results of examples 3, 12-18 and comparative examples 4-5, the average daily gain of beef cattle fed with the beef cattle feed obtained in examples 3 and 12-17 is 1.46-1.66 kg/head, the feed-meat ratio is 7.12-7.74, the average daily gain of beef cattle fed with the beef cattle feed obtained in example 18 is 1.43 kg/head, the feed-meat ratio is 8.11, the average daily gain of beef cattle fed with the beef cattle feed obtained in comparative examples 4-5 is 0.98-1.04 kg/head, and the feed-meat ratio is 9.23-9.39, which means that the intelligent release type feed additive is prepared by adopting the nutrition particles, the slow release layer and the acid-base buffer layer, and the weight ratio of the nutrition particles, the slow release layer and the acid-base buffer layer is controlled within the range of 5 (0.3-1), and the intelligent release type feed additive has better growth promotion effect on beef cattle and better growth performance.
In conclusion, the intelligent release type feed additive provided by the application can intelligently regulate the pH value change of intestines and stomach in the digestion process of beef cattle and release nutrient substances under proper conditions, so that the beef cattle can fully absorb the nutrient substances, the feed conversion ratio is improved, the growth performance and the health state are improved, the cultivation benefit of a farm is further increased, and the intelligent release type feed additive has good economic value and application prospect.
While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (10)
1. An intelligent release type feed additive is characterized by comprising nutrition particles, a slow release layer and an acid-base buffer layer which are sequentially coated on the outer surfaces of the nutrition particles;
the slow release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4) -2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate;
The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide with a weight ratio of 1 (0.17-0.36).
2. The intelligent release type feed additive according to claim 1, wherein the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1 (0.21-0.32).
3. The intelligent release type feed additive according to claim 1, wherein the slow release layer is a mixture of cellulose acetate phthalate and tetrandrine.
4. The intelligent release type feed additive according to claim 1, wherein the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.1-0.5).
5. The intelligent release type feed additive according to claim 1, wherein the weight ratio of the cellulose acetate phthalate to the tetrandrine is 1 (0.2-0.4).
6. The intelligent release type feed additive according to claim 1, wherein the nutritional granules comprise 1-2 parts by weight of amino acid, 1-2 parts by weight of mineral and 0.5-0.8 parts by weight of vitamin.
7. The intelligent release type feed additive according to any one of claims 1 to 6, wherein the weight ratio of the nutrition particles, the slow release layer and the acid-base buffer layer is 5 (0.3 to 1): 0.3 to 1.
8. The method for preparing an intelligent release type feed additive according to any one of claims 1 to 7, comprising the steps of:
The method comprises the steps of uniformly mixing all the components of the nutrition particles, granulating to obtain nutrition particles, spraying moisture on the surfaces of the nutrition particles, mixing with a slow-release layer material, uniformly shaking to enable the surfaces of the nutrition particles to be fully coated with the slow-release layer material to obtain prefabricated particles, continuously spraying moisture on the surfaces of the prefabricated particles, mixing with an acid-base buffer layer material, and uniformly shaking to enable the surfaces of the prefabricated particles to be fully coated with the acid-base buffer layer material to obtain the intelligent release type feed additive.
9. Use of the smart release feed additive of any one of claims 1-7 in animal feed.
10. A beef cattle feed characterized by comprising the intelligent release feed additive according to any one of claims 1-7, wherein the weight ratio of the intelligent release feed additive to the beef cattle feed is 1.5-2.5g/kg.
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